CN101507765A - Medicine for treating cerebrovascular disease and sequela thereof and preparation method thereof - Google Patents
Medicine for treating cerebrovascular disease and sequela thereof and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medicament for treating cardiovascular and cerebrovascular diseases and sequela of the same, which is prepared from the following raw Chinese medicaments in portion by weight: 120 to 140 portions of radix notoginseng, 100 to 120 portions of earthworm, 100 to 120 portions of leech, 120 to 150 portions of Astragalus membranaceus, 60 to 90 portions of Chuanxiong rhizome, 60 to 90 portions of safflower, 120 to 140 portions of peach kernel, 90 to 120 portions of red sage root and 110 to 130 portions of pearl. The medicament has simple formulation, consolidated treatment effect and easy preparation, is convenient for patients to take, can be used for treating the patients who are weak due to suffering from diseases for a long time and suffer from other diseases, and is particularly suitable for the patients who simultaneously have cardiovascular and cerebrovascular diseases.
Description
Technical field
The present invention relates to a kind of medicine, particularly relate to a kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease and sequela shape thereof.
Background technology
The similar technology of existing treatment diseases of cardiovascular and cerebrovascular systems is many based on blood vessel dilating or change blood viscosity, improvement to the sequela shape has little significance, opposite side effects of pharmaceutical drugs and dependency are bigger, send out the probability height after the drug withdrawal again, must take all the year round, patient spends many, the cost height, and cardiovascular and cerebrovascular vessel patient is many, and the course of disease is long, a little less than the empty gas of patient body, the kind of taking medicine is many, and cardiovascular disease and cerebrovascular disease merge outbreak sometimes, need use multiple medicine simultaneously, be easy to generate incompatibility between the medicine.
Summary of the invention
Technical problem to be solved by this invention be to provide that a kind of cost is low, taking convenience, prescription be simple, side effect, dependency are little, efficacy consolidation is made the medicine that is easy to be used for the treatment of cardiovascular and cerebrovascular disease and sequela thereof.
The present invention seeks to realize like this, a kind of medicine that is used for cardiovascular and cerebrovascular disease and sequela thereof, make by following parts by weight of traditional Chinese medicines crude drug:
Radix Notoginseng: 120-140; Pheretima: 100-120; Hirudo: 100-120; The Radix Astragali: 120-150; Rhizoma Chuanxiong: 60-90; Flos Carthami: 60-90; Semen Persicae 120-140; Radix Salviae Miltiorrhizae: 90-120; Margarita: 110-130.
A kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease and sequela thereof of the present invention, wherein: make by following parts by weight of traditional Chinese medicines crude drug:
Radix Notoginseng: 130-140; Pheretima: 110-120; Hirudo: 110-120; The Radix Astragali: 130-140; Rhizoma Chuanxiong: 80-90; Flos Carthami: 70-90; Semen Persicae 120-130; Radix Salviae Miltiorrhizae: 90-110; Margarita: 110-120.
A kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease and sequela thereof of the present invention, its preferred consumption is:
Radix Notoginseng: 140 grams, Pheretima: 110 grams, Hirudo: 114 grams, the Radix Astragali: 132 grams, Rhizoma Chuanxiong: 85 grams, Flos Carthami: 86 grams, Semen Persicae 130 grams, Radix Salviae Miltiorrhizae: 110 grams, Margarita: 110 grams.
A kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease and sequela thereof of the present invention, it can make various peroral dosage forms, comprises granule, tablet, drop pill, oral liquid, capsule etc., is preferably pill.
The present invention also provides a kind of preparation method that is used for the treatment of cardiovascular and cerebrovascular disease and sequela pill thereof, in described ratio each medicine is mixed, be processed into fine powder, again according to the mixed of 3:1 evenly and make the pill of 1 to 3 millimeter of diameter, also oven dry of 100 ℃ of sterilizations of reuse high-temperature sterilization case with above-mentioned medicated powder and Mel.
The present invention is used for the treatment of the preparation method of cardiovascular and cerebrovascular disease and sequela pill thereof, wherein with after 100 ℃ of sterilization of high-temperature sterilization case and drying, and per 12 grams of dried pill one bag, plastic packaging, per 40 bags are portion, vacuum packaging.
Radix Notoginseng, put down in writing according to Compendium of Material Medica: (People's Health Publisher publishes, the 2nd printing of in JIUYUE, 1985 front page.Sweet little hardship down together), temperature, nontoxic.Go into liver, stomach, large intestine channel.Hemostasis, the blood that looses, analgesic therapy, the clots absorbing of promoting blood circulation.According to " Chinese medicine voluminous dictionary " record (Science and Technology of Shanghai publishing house, the 8th printing of nineteen ninety-five December.Down with): the Radix Notoginseng rhizome contain arasaponin A (ArasaponinA, C30H52O10) and arasaponin B (Arasaponin B, C23H38O10).Zoopery can be shortened clotting time, and slower haemolysis is also arranged simultaneously.Can blood pressure lowering also can reduce capillary permeability, increase the blood capillary drag.Have the sterilization diuresis concurrently.
Pheretima is put down in writing according to Compendium of Material Medica: salty-cold.Go into liver, spleen, lung meridian.Heat clearing away, suppressing the hyperactive liver, Zhichuan, collateral dredging.Put down in writing according to " Chinese medicine voluminous dictionary ": various Lumbricuss contain lumbrifebrine (Lumbrifebrine), lumbricin (Lumbritin), terrestro-lumbrolysin (Terrestro-lumbrolysin).LUMBRICUS contains hypoxanthine (Hypoxanthine) etc.Lumbricus contains aminoacid such as nitrogen substance such as alanine, valine, leucine, phenylalanine, tyrosine, lysine again, and xanthine (Xanthine) adenine (Adenine), guanine (Guanine), choline (Choline), guanidine (Guanidine) etc.Contain the fatty acid of stearic acid, Palmic acid, highly unsaturated fatty acid, straight-chain odd number carbon and paniculate fatty acid, phospholipid, cholesterol etc. in the lipid of Lumbricus (Lumbricusspencer) part.In the yellow cell tissue of Lumbricus (L.terrestris) (Chlorogogen tissue), contain carbohydrate, lipid, protein and color element; Contained basic amino acid has histidine, arginine, lysine; Its flavochrome may be riboflavin (Riboflavine) or its similar substance.Lumbricus contains a kind of enzyme, can make the Lumbricus dissolving when pH8.0-8.2.Zoopery has blood pressure lowering, calmness, anticonvulsant action.The direct effect of its leachate can make vasoconstriction, and central action then can distend the blood vessels.
Hirudo is put down in writing according to Compendium of Material Medica: salty hardship, and flat, poisonous.Go into liver, urinary bladder channel.Removing blood stasis, removing blood stasis.Put down in writing according to " Chinese medicine voluminous dictionary ": Hirudo mainly contains protein.Contain a kind of anticoagulative substance hirudin (Hirudin) by name in the fresh Hirudo saliva.Hirudin is not heated or the destruction of ethanol, can stop the effect of thrombin to fibronectin, hinders blood coagulation.
The Radix Astragali is put down in writing according to Shennong's Herbal: (People's Health Publisher publishes, the 2nd printing of JIUYUE in 1985.Down together) sweet, tepor.Go into lung, spleen channel.Give birth to and use: benefit is defended consolidating superficial resistance, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening.Process usefulness: invigorating the spleen and replenishing QI.Put down in writing according to " Chinese medicine voluminous dictionary ": Radix Astragali contains sucrose, glucuronic acid, phlegmatic temperament, several aminoacid, bitter principle, choline (Choline), betanin (Betaine), folic acid (the dried root of per 100 grams of 65 micrograms), tell 2` again, 4`-dihydroxy-5,6-dimethoxy isoflavan (2`, 4`-ODihydroxy-5,6-dimethoxyisoflavane) kumatakenin (Kumatakenin).Tell linoleic acid, linolenic acid in the saponification resultant of Inner Mongol Radix Astragali lipid; Cupreol (β-Sitosterol) is arranged in the non-saponification part.Zoopery has tangible diuresis, blood pressure lowering, antiinflammatory, strong effect, can increase cardiac output, promotes blood circulation.
Rhizoma Chuanxiong is put down in writing according to Shennong's Herbal: suffering, temperature.Go into liver, gallbladder meridian.Activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain.Put down in writing according to " Chinese medicine voluminous dictionary ": rhizome contains volatile oil, alkaloid, phenol sexual element, lactone, ferulic acid.Zoopery has excitation to medulla oblongata vasomotor center, respiratory center and spinal reflex, and heart is had direct dilating effect, and smooth muscle is had the spasmolytic effect, and multiple pathogenic bacteria is had inhibitory action.In addition, the effect that has vitamin antagonist E to lack.
Flos Carthami is put down in writing according to Compendium of Material Medica: sweet, flat.Go into the heart, Liver Channel.Blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens.Put down in writing according to " Chinese medicine voluminous dictionary ": flower contains carthamin (Croein) about 2%, be the ester of Flos Carthami acid (Crocetin) and two molecule gentiobiose be combined intos, contain Flos Carthami dimethyl phthalate (Crocetin dimethyl ester), about 2% (Picrocrocin) of Flos Carthami bitter principle, volatile oil 0.4-1.3% (being mainly Flos Carthami acid Safranal) again.Flos Carthami aldehyde is that the hydrolysis of Flos Carthami bitter principle generates.Carthamin and Flos Carthami bitter principle may be combined into former carthamin (Picrocrocin) and be stored in the crude drug.Contain abundant vitamin B2 again.Bulb content glucose, aminoacid, Saponin.Zoopery has very strong bringing high blood pressure down, excited heart and Repiration.
Semen Persicae is put down in writing according to Shennong's Herbal: hardship, and flat.Go into the heart, liver, large intestine channel.Blood stasis removing and clots absorbing is moisturized laxation.Put down in writing according to " Chinese medicine voluminous dictionary ": it is about 3.6% that Semen Persicae contains amygdalin (Amygdalin), volatile oil 4%; Main olein and a small amount of linoleic acid glyceride of containing in the oil. other contains emulsin (Emulsin) zoopery anticoagulant effect and more weak haemolysis.
Radix Salviae Miltiorrhizae is put down in writing according to Shennong's Herbal: hardship, tepor.Go into the heart, Liver Channel.Blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, evacuation of pus, pain relieving.Contain furo phenanthrenequione class pigment Tanshinone I (TanshinoneI), tanshinone (Tanshinone IIA), ginseng ketone IIB (Tanshinone IIB), cryptotanshinone (Cryptotanshinone), iso tanshinone I (IsotanshinoneI), iso tanshinone II (Isotanshinone II), different cryptotanshinone (Isocryptotanshinone), miltirone (Miltirone) according to " Chinese medicine voluminous dictionary " record root.Other isolates tanshinol I (Tanshinol I, C19 H 24 O2,129 degrees centigrade of fusing points) and tanshinol II (Tanshinonl II).Still contain vitamin E in addition, effectiveness and Fructus Hordei Germinatus are suitable.Zoopery, Radix Salviae Miltiorrhizae leachate intravenous injection 0.25mg has blood pressure lowering, vasorelaxation action and blood vessel dilating effect to mice, and blood sugar lowering and antiinflammatory action are arranged.
Margarita is put down in writing according to " Kaibao Bencao ": (People's Health Publisher publishes, the 7th printing of December in 1987.) salty sweet, cold, nontoxic.Go into the heart, Liver Channel.Tranquilizing mind, skin maintenance, broad heat is weighed down expectorant, and removing nebula makes eye bright, and yin nourishing relieves dizziness, high fever, infantile convulsions, epilepsy, etc., removing toxic substances and promoting granulation.Put down in writing according to " Chinese medicine voluminous dictionary ": the main calcium carbonate that contains.Are rich in elements such as aluminum, copper, ferrum, magnesium, manganese, sodium, zinc, silicon, titanium, strontium in the Margarita.Heart there is extremely strong Nutrition.
More than all medicine compatibilities, Radix Notoginseng, Pheretima, Hirudo are monarch, main merit of building blood circulation promoting and blood stasis dispelling; Flos Carthami, Semen Persicae, Radix Salviae Miltiorrhizae are minister, the effect of the row antiinflammatory circulation of qi promoting of holding concurrently; Assistant is with the Radix Astragali, Margarita, to set upright, brain-strengthening, to nourish heart; Rhizoma Chuanxiong is for making, lead all medicines go into through.The all hemorrhage energy of Radix Notoginseng, Pheretima, Semen Persicae ends, blood stasis can loose, two-way therapeutical effect is arranged, so can be used for sclerosis of blood vessels, infraction, thrombosis etc. owing to blood circulatory disorder and because hyperlipidemia, the cardiovascular and cerebrovascular disease that high blood viscosity, hypercholesterolemia, hyperglycemia cause also can be used for all diseases of cerebral hemorrhage simultaneously.Radix Notoginseng, Rhizoma Chuanxiong all have antiinflammation concurrently, share mutually to making, and increase and render a service, the pulmonary infection that can prevent the cardiovascular and cerebrovascular disease patient can not self-cleaning to cause because of movable difficult, pulmonary.Flos Carthami and Radix Salviae Miltiorrhizae have very strong blood pressure lowering, cardioexcitatory effect, and myocardial infarction, infarction are had extremely strong prevention, therapeutical effect, be used for aroused in interest uneven, curative effect to treat angina pectoris is remarkable, can effectively prevent and treat bradycardia, overrun, all standing.Radix Salviae Miltiorrhizae has very strong removing blood stasis effect concurrently, with the shared special efficacy that can gather blood stasis dispersing and fresh blood promoting altogether of Radix Notoginseng, Pheretima, Semen Persicae.Radix Astragali invigorating the spleen and replenishing QI, holding concurrently can diuretic.Qi as the commander of blood, then blood flow is unobstructed for the gas foot, and blood vessel moistens supports fully, and diuretic energy blood pressure lowering also promotes the circulation of blood vessel tip, improves body function, and the apoplectic hemiplegia patient that cordis and cerebral accident causes then must have a delicate constitution for a long time, appropriate its usefulness of the Radix Astragali.Margarita is rich in various trace elements, and heart is had extremely strong Nutrition, so be used for the treatment of cardiovascular and cerebrovascular disease with medicine-feeding, can prevent to have a weak heart, hypofunction, is particularly useful for cardiovascular disease, and curative effect is very remarkable.Rhizoma Chuanxiong pass through the twelve regular channels, kindly walk to scurry, extremely strong penetration power is arranged, share with Hirudo, can break through blood brain barrier, overcome the defective that general medicine can not be broken through blood brain barrier, directly stimulate the cranial nerve root cells, the effect neuron activates brain cell, repairs focus.Now changing medical research proves, be under people's the brain cell normal condition activate duty less than 10 of all brain cells, all the other a large amount of brain cells all are in resting state.Stimulate the cranial nerve root cells, can activate the brain cell of resting state, thus the effect of compensatory impaired brain cell, and can finish memory and transmit functionally with other, finally repair focus, restore funcitons.Even if perhaps focus can not be repaired fully, but brain function is normal fully, and body function recovers fully, can reach the purpose of thorough treatment equally.After rhizoneure is activated, can stimulate bone marrow to produce the high-quality hemoglobin simultaneously or improve the oxyphie ability of hemoglobin, improve unit number hemoglobin oxyphie ability, can reduce the hemoglobin number, thereby reduce blood viscosity, promote blood circulation, strengthen blood vessel elasticity, recover blood vessel blood supply vigor, progressively remove harmful substance residual in the blood, recover the normal composition of blood, eradicate focus.Reduce when people are movable, overnutrition will cause blood residuals matter too much, the metabolism in time of these residuals, will cause blood fat, cholesterol, blood glucose etc. progressively raise, and then cause poor blood circulation, poor blood circulation then blood oxygen carrying capability weakens, when human brain perception blood oxygen lacks, will stimulate bone marrow to produce more hemoglobin with compensatory oxyphie deficiency, supply blood oxygen.Hemoglobin is more and more, and of a specified duration will cause high blood viscosity.So just enter the vicious cycle state, blood is thickness more and more.Influence blood vessel elasticity then gradually, cause the cardiovascular and cerebrovascular vessel sclerosis of going forward one by one, produce cardiovascular and cerebrovascularinfarction or thrombosis, blood vessel embrittlement, hyperpiesia then cause cerebral hemorrhage.Comprehensively above-mentioned, the present invention can fundamentally treat diseases of cardiovascular and cerebrovascular systems and lose syndrome and other blood circulation and angiopathy disease thereafter.
Medicine of the present invention can be used for treating the patient of cardiovascular and cerebrovascular disease and sequela thereof, be specially adapted to be associated with simultaneously the patient of cardiovascular and cerebrovascular disease, the people who suffers from cardiovascular and cerebrovascular disease simultaneously, medicament composing prescription of the present invention is simple, making is easy, cost is low, side effect, dependency are little, taking convenience, efficacy consolidation.
The specific embodiment
For further specifying the present invention, with the following Examples with the explanation of clinic trial example:
Embodiment 1,
A kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease and sequela thereof, make by following raw material of Chinese medicine medicine, after collections such as described Chinese medicine Radix Notoginseng, Pheretima, Hirudo, the Radix Astragali, Rhizoma Chuanxiong, Flos Carthami, Semen Persicae, Radix Salviae Miltiorrhizae, Margarita, with described Chinese medicine clean it up, clean it up: refer to above-mentioned Chinese medicine fine selection, beat and crumple or clean out, can not wash with nonmetal instrument wiper.After ultraviolet radiation disinfection is distinguished dryness in the sun then, wherein Pheretima removes the assorted soil of clean intracavity with described Chinese medicine clean it up.Radix Notoginseng gives birth to usefulness, the Hirudo processed with honey, and Radix Astragali processed with honey, the Rhizoma Chuanxiong selection totally gets final product, and the Flos Carthami selection totally gets final product, and Semen Persicae Jiang Shui fries, and the Radix Salviae Miltiorrhizae selection totally gets final product, and Margarita is chosen good person and gets final product.After handling medicine in a manner described, be placed on 120 ℃ of sterilizations of high-temperature sterilization case and oven dry again.Press Radix Notoginseng: 140 grams, Pheretima: 110 grams, Hirudo: 114 grams, the Radix Astragali: 132 grams, Rhizoma Chuanxiong: 85 grams, Flos Carthami: 86 grams, Semen Persicae 130 grams, Radix Salviae Miltiorrhizae: 110 grams, Margarita: 110 grams mix each medicine, be processed into fine powder, again according to the mixed of weight ratio 3:1 evenly and make the pill of 1 to 3 millimeter of diameter, also oven dry of 100 ℃ of sterilizations of reuse high-temperature sterilization case with above-mentioned medicated powder and Mel, per 12 grams of dried pill one bag, plastic packaging, per 40 bags are portion, vacuum packaging.
Embodiment 2,
The inventor utilizes the pill of embodiment 1 gained to carry out long-time observation on Clinical Application, now according to 512 routine clinical treatment observations: patient's mean age is 62.5 years old, the maximum is 94 years old, reckling is 39 years old, wherein the male has: 358 examples, the women has 154 routine therapeutic domains to comprise except cerebrovascular disease such as cerebral infarction, also comprise cardiovascular system diseases such as hypertension, coronary heart disease, atherosclerosis, and the sequela shape of above-mentioned disease, using method, for twice, each 1 wrapping sooner or later every day, take with warm water; As the prolonged illness deficiency of both QI and blood, get the Radix Astragali 5g every day, Radix Angelicae Sinensis 5g fries in shallow oil water delivery service; As it is not enough to have weakened body resistance immunity concurrently, and Ramulus et folium taxi cuspidatae 3g, Herb Gynostemmae Pentaphylli 2g fry in shallow oil water delivery service; 20 days is a course of treatment, serve on for four to six courses of treatment, avoids cold and uncooked food, wine and maror.Patient's radical rate is: 61.1%, and totally there is effective percentage to be 90.2% (total effective rate be meant that patient's number that patient's number of radical cure adds produce effects is divided by total patient's number after, the number of gained multiply by absolutely).Do not see any drug side effect.
Wherein simple cardiovascular disease
136Example is taken medicine of the present invention,
78Example patient radical cure, patient's radical cure is meant: patient symptom is clearly better, and precordial significant discomfort disappears, and electrocardiogram has obvious myocardial ischemia change to disappear, and below the blood pressure 140/90mmhg, follows up a case by regular visits to not morbidity once more in 6 months to 1 year;
34 examplesPatient's produce effects, produce effects is meant: though the patient disease does not fully recover still: patient symptom is clearly better, and controlling of blood pressure is steady, and life can be taken care of oneself, and follows up a case by regular visits to not morbidity once more in 6 months to 1 year;
Simple cerebral infarction
157Example, hemiplegia, facial hemiparalysis, coma, the tongue deadlock, hemianesthesia is taken medicine of the present invention, and the patient of radical cure is
109Example, radical cure refers to: conscious, language performance is normal, and the upper and lower extremities joint motion is normal, and life can be taken care of oneself, and sequela all disappears, and focus is recovered, and follows up a case by regular visits to not morbidity once more in 6 months to 1 year; Produce effects
27Example, though produce effects refers to that the patient does not effect a radical cure mind and gradually regains consciousness, language performance returns to can finish daily interchange, the joint can be movable among a small circle, but muscular strength is poor, and a little less than the power, sequela partly disappears, and not morbidity once more in 6 months to 1 year is followed up a case by regular visits in the basicly stable or calcification of focus.
Cardiovascular disease merges its cerebrovascular disease patient
219Example, the patient has after taking except that the symptom that above-mentioned cardiovascular and cerebrovascular disease is arranged
126The example radical cure, radical cure refers to: conscious, language performance is normal, and the upper and lower extremities joint motion is normal, and life can be taken care of oneself, sequela all disappears, focus is recovered, and blood pressure is normal, and the precordial significant discomfort in movable back disappears, electrocardiogram has obvious myocardial ischemia to change disappearance, follows up a case by regular visits to not morbidity once more in 6 months to 1 year; Produce effects
88Example is not effected a radical cure though produce effects refers to the patient, and mind is gradually clear-headed, and language performance returns to can finish daily interchange, and the joint can be movable among a small circle, but muscular strength is poor, and a little less than the power, sequela partly disappears, and not morbidity once more in 6 months to 1 year is followed up a case by regular visits in the basicly stable or calcification of focus.
Choose the some of them case below:
Example 1, Chen, the man, in April, 1954 birth, on July 9th, 2007 fell ill after drinking, and emergency treatment is in People's Hospital of Shanxi Prov., admission number: 270933, the coronal artery angiography Zhi Yanchong infraction of finding to circle round, near 95%, be diagnosed as the severe acute myocardial infarction, a stenting subsequently circles round in the execution right side, Fuwai Hospital, Beijing.The postoperative oral aspirin, thrombolytic drugs such as Bo Liwei, network is glad logical, WENXIN KELI, Chinese patent medicines such as Radix Salviae Miltiorrhizae drop pill, and regularly intravenous drip MAILUONING, Radix Salviae Miltiorrhizae Injection.But still the tight dry pharynx of larynx is arranged, and weak all over, the pareordia paroxysmal pain.Produce above-mentioned symptom during on November 11st, 2007, and thready and weak pulse, 51 times/minute, face is pale simple and unadorned, and at this moment, other position infractions of patient's heart can't be implemented support because blood vessel is meticulous, still are in the infraction state.Execute to the ill and control, blood circulation promoting and blood stasis dispelling, benefiting qi and nourishing blood.Every day sooner or later respectively obeyed a bag after meal by oral medicine of the present invention, gets Radix Astragali 5g, Radix Angelicae Sinensis 5g fries in shallow oil water delivery service, diet: raw and cold, pungent, seafood, wine and greasy food.After taking medicine 3, precordialgia subtracts greatly, and precordialgia disappearance and pharyngeal discomfort are gradually light after 20 days, the basic recovery normally on the 80th of taking medicine, normally working after taking medicine 120.So far safe and comfortable, advise it need not drink as far as possible, to stay up late less, the polyphagia light food is strengthened taking exercise, and follows up a case by regular visits to not morbidity again in 1 year.
Example 2, Bai, man, birth in October nineteen sixty-eight, in July, 2005, this patient causes asthma because of influenza, day by day increases the weight of, and goes into the treatment of big second Affiliated Hospital of Shanxi medical courses in general, is diagnosed as allergic asthma, and sense alleviates slightly.Because of be busy with one's work, fail continue treatment thereafter.In January, 2008, because of influenza causes asthma, heavier again than last time.It is violent to pant, and can not put down for sleeping in substantially.Reentering the big second Affiliated Hospital's symptomatic treatment of Shanxi medical courses in general fails to alleviate.Change People's Hospital of Shanxi Prov. subsequently over to,, be diagnosed as the heart mitral incompetence, tricuspid stenosis, serious symptom myocardial ischemia, pulmonary infection, admission number: 178932 through nuclear magnetic resonance check.Antibiotic such as intravenous drip fructose, digoxin, import cefobid, after ten days slightly sense alleviate, but anasarca appears, restless.January 28 in 2008 patient, oral this invention medicine is sooner or later respectively obeyed a bag after meal, Ramulus et folium taxi cuspidatae 3g, Herb Gynostemmae Pentaphylli 2g, diet: raw and cold, pungent, seafood, wine and greasy food.The patient took medicine 10, panted and pacified, and all diseases all disappear after taking medicine 40 days, and things are as usual, and clothes are after 120 days, and the color doppler flow imaging of Taiyuan City central hospital is checked, the cardiac structure no abnormality seen.Advise it can not be overworked, and will strengthen corresponding exercise.Following up a case by regular visits to 1 year patient does not reaccess.
Example 3 Lee, man, be born in December, 1934, be diagnosed as, heart infarction and multiple cerebral infarction, slight cardiorenal failure through the commercial worker of Taiyuan City hospital.Admission number: 33170, anasarca, legs and feet are more so.Confusion of thinking, dysphonia, slobbering, dyspnea is unable to leave the bed, thready and weak pulse without strength.On August 8th, 2008 oral this invention medicine, sooner or later respectively obey a bag after meal every day, Ramulus et folium taxi cuspidatae 3g, Herb Gynostemmae Pentaphylli 2g fry in shallow oil water delivery service, diet: raw and cold, pungent, seafood, wine and greasy food.Took medicine 20 days, sense takes effect slightly, and edema disappears after 30 days, the activity of getting up on a small quantity.First Affiliated Hospital of University Of Shanxi check after taking medicine 80 days, cardiorenal failure is healed, breathes smooth-going.Movable normal after 100 days, but can not be lasting.Electrocardioscopy ST section does not have and moves down after 120 days, and the Q ripple is no abnormal.In JIUYUE, 2008 Taiyuan City commercial worker hospital check, left encephalocoele has the little calcification kitchen range of a 0.3 * 0.2mm, and other infarction lesion disappears.So far basic the recovery normally.Following up a case by regular visits to 6 months patients does not reaccess.
Example 4, Lee, woman, 67 years old age, there are dizziness, headache, the numb phenomenon of both hands the beginning in March, 2005, increases the weight of gradually to May in the same year, the troxerutin of clinic intravenous drip nearby, Radix Salviae Miltiorrhizae, No. 0, oral blood pressure lowering, aspirin, and intravenous drip MAILUONING, Herba Asari oil lamp, sense takes a turn for the better slightly.In November, 2005, dysarteriotony increased suddenly, hemiplegia, and on November 11st, 2005, second Affiliated Hospital of University Of Shanxi was diagnosed as the multiple lacunar infarction of brain basal ganglia region, hypertension (180/110mmhg).Admission number: 099978, it is unable to look into deep and weak pulse, thinking and hypomnesis.This patient's bluish complexion simple and unadorned, the bluish lip crimson tongue, both hands refer to numbness, right hemiplegia, dizzy headache, the neck item is stiff, eyes expand to be stranded, blurred vision, transient vertigo.On November 8th, 2006, oral medicine of the present invention, sooner or later respectively obey a bag after meal every day, and Ramulus et folium taxi cuspidatae 3g, Herb Gynostemmae Pentaphylli 2g fry in shallow oil the water delivery service diet: raw and cold, pungent, seafood, wine and greasy food.Take medicine and took effect in 5 days, the steady blood pressure 130/80mmhg of blood pressure on the 15th, dizzy headache disappears after 40 days, and limb activity recovers after 60 days.Continued to take medicine 120 days, all diseases are all healed, and health is as usual, the complete obiteration of the multiple lacunar infarction focus of in November, 2007 University Of Shanxi's second Affiliated Hospital's nuclear magnetic resonance check brain basal ganglia region.Following up a case by regular visits to 2 years patients does not reaccess.
Example 5, Lu, woman, 68 years old, in August, 2006, be diagnosed as multiple lacunar infarction through the Xinzhou City the People's Hospital, retardance two rooms in IV atrium increase, and left chamber diastolic function lowers, slight cerebral arteries high pressure, sinus bradycardia (about 38 times/minute), cerebral ischemia, the ST section changes, admission number: 7768.This hospital diagnosed and developed into myocardial infarction once more in February, 2007, and the cardiac stent art is implemented in suggestion.Due to illness people and family members fear, and fail to implement.Take doubly its happy gram, Radix Salviae Miltiorrhizae drop pill, No. 0, blood pressure lowering, comfortable granule, WENXIN KELI, Kang Xin for a long time, and regularly intravenous drip Energy mixture, MAILUONING, DANHONG, XUESAITONG, no obvious curative effects.The patient is weak all over, and the breast of breathing hard is suppressed, the purple bluish lip of face, and palpitation with fear is irritated, and pareordia and echo area, back pain are not peaceful, and frightened difficulty is slept.Oral this invention medicine of patient, sooner or later respectively obey a bag after meal every day, and Ramulus et folium taxi cuspidatae 3g, Herb Gynostemmae Pentaphylli 2g fry in shallow oil water delivery service, diet: raw and cold, pungent, seafood, wine and greasy food.Take medicine and took effect in 20 days, can fall asleep safely after 40 days, taking medicine to 100 days above-mentioned symptoms disappears substantially, and recovery from illness after 120 days just like in the past, is followed up a case by regular visits to not morbidity again in 1 year.In August, 2008, the CT of Xinzhou City the People's Hospital cerebral infarction focus disappears, color ultrasound electrocardiogram check no abnormality seen.
Example 6, field, woman, 74 years old, this patient goes into People's Hospital of Shanxi Prov.'s emergency treatment, admission number in JIUYUE in 2006 morbidity on the 6th: 173241, nuclear magnetic resonance check shows that atherosis, the two artery of lower extremity of heart coronary artery is atherosis; Coronarography is checked, is shown as heart anterior descending branch infraction and preceding lower wall small size necrosis.Implement stenting and intravenous drip thrombolytic drug immediately, oral Pohle dimension, aspirin, digoxin, WENXIN KELI, Radix Salviae Miltiorrhizae drop pill etc., JIUYUE state of an illness on the 13rd increases the weight of, and does the coronary angiography inspection again, circling round and prop up infraction in the demonstration heart right side, implements the support operation immediately once more.Unstable angina pectoris ever since, blood pressure is high, nearly 180/120mmhg.On January 6th, 2007, the room was early rich, ventricular premature contraction and aroused in interest uneven extremely serious except that above-mentioned symptom, and simultaneously with asthma, back cardiac reflex district pain, deep-slow pulse is unable.On January 6th, 2007, the patient took this invention medicine, sooner or later respectively obeyed a bag after meal, got Radix Astragali 5g, Radix Angelicae Sinensis 5g fries in shallow oil water delivery service, diet: raw and cold, pungent, seafood, wine and greasy food.Week back angina pectoris and the back echo area pain of taking medicine disappears, and 20 days metathoraxes are suppressed asthma and disappeared, and words and complexion change red after 60 days, take medicine after 80 days blood pressure normal (125/85mmhg), pulse normal (64 times/minute), premature beat disappears, and mental attitude is taken on an entirely new look.Walking, life after 120 days, take exercise as before.In July, 2008, People's Hospital of Shanxi Prov.'s nuclear magnetic resonance check showed that heart is preced with structure, function is normal, the atherosis recovery of two artery of lower extremity; Coronarography is checked, is shown as heart anterior descending branch infraction and alleviates (about 20%), preceding lower wall special mess necrosis.Follow up a case by regular visits to not morbidity again in 1 year.
Example 7, field, man, 72 years old, fall down when in March, 2002, refined morning, hemiplegia can not be walked subsequently, and on March 15th, 2002, first Affiliated Hospital of University Of Shanxi was diagnosed as multiple cerebral infarction, by the bilateral ventricles of the brain, center, basal ganglia region half ovum garden, the multiple lacunar infarction of pon, part is outmoded focus, bilateral pon relief angle myelin changes (attaching most importance in the right side), admission number: 077769.Patient's outpatient service intravenous drip nearby fourth lattice ground that, nourishing brain, MAILUONING are suppressed manic uneasiness from head to foot after three days.Discontinuing medication occurs the language function forfeiture afterwards, and confusion of thinking is cryed and laugh by turns, without any apparent reason.Long-term oral pill ginseng dripping pill, BUCHANG NAOXINTONG, network are glad logical, Rhizoma Gastrodiae Pilulae, and the state of an illness day by day increases the weight of.On May 14th, 2006, there has not been locomotor activity, left hand and arm are stiff stiff.Full and large pulse, the purple lip conjunctival congestion, tongue is stiff not to be gone out.Oral this invention medicine of patient's on May 14th, 2006, sooner or later respectively obey a bag after meal every day, and Ramulus et folium taxi cuspidatae 3g, Herb Gynostemmae Pentaphylli 2g fry in shallow oil water delivery service, diet: raw and cold, pungent, seafood, wine and greasy food.Take medicine and took effect, be emotionally stable, can walk on their own in 40 days to 20 days, language functional rehabilitation on the 80th, it is normal to all functions recovery in 120 days to take medicine.In October, 2,007 first Affiliated Hospital of University Of Shanxi spiral CT check, the cerebral infarction foci disappearance.
Example 8, Wang, woman, 68 years old, all be diagnosed as coronary heart disease through inspections such as railway hospital, People's Hospital of Shanxi Prov., big first Affiliated Hospital of Shanxi medical courses in general, big second Affiliated Hospital of Shanxi medical courses in general, the repeatedly physico-chemical examination of Shanxi Province's coal hospital, spiral CT, nuclear magnetic resonance, NMR, PKCT, the serious symptom heart infarction, (a slight infraction that the coronary artery moderate is blocked, side arm props up and circle round in the right side) cerebral blood supply insufficiency.Railway hospital admission number: 09991, People's Hospital of Shanxi Prov.'s admission number: 999011, Mountain Western Medicine S University's first Affiliated Hospital's admission number: 111332.On June 13rd, 2008, patient's anasarca, cough with asthma is more than, lies awake all night, and can not independently take action, and begins to take medicine of the present invention, sooner or later respectively obeys a bag after meal, and Ramulus et folium taxi cuspidatae 3g, Herb Gynostemmae Pentaphylli 2g fry in shallow oil water delivery service, diet: raw and cold, pungent, seafood, wine and greasy food.Sense is effective slightly after taking medicine 10, obviously takes effect after 40 days, and above-mentioned all diseases disappear substantially after 120 days, and it is as usual to live, and in December, the 2008 Shanxi coal PKCT of hospital check cardiac valve is closed normally the structure no abnormality seen.Same month Shanxi Province's cardiovascular research institute coronary angiography check coronary atherosclerosis, other no abnormality seens.Follow up a case by regular visits to and do not reaccess in 1 year.
Example 9, Xing, man, 42 years old, the existing Light-headedness phenomenon of this patient of in mid-January, 2008, April 16 because of and household's anger, morbidity next day.Be the subacute cerebral infarction of large tracts of land with the big First Academy in the mountain consultation of doctors behind the unenhanced and angiography of the total institute of Taiyuan Iron and Steel Co. nuclear magnetic resonance, NMR head.April 18 the same year, this patient's deep-slow pulse, bluish complexion is simple and unadorned, expression is dull, and it pisses on ice, and seldom physical exertion is so that phlegm resistance, qi depression to blood stasis, clear YANG failing to ascend is taken medicine of the present invention, respectively obeys a bag sooner or later after meal, Ramulus et folium taxi cuspidatae 3g, Herb Gynostemmae Pentaphylli 2g fry in shallow oil water delivery service, diet: raw and cold, pungent, seafood, wine and greasy food.On May 4 the same year, when doing the PKCT check in coal hospital, focus is clearly better, and symptom obviously alleviates.After serveing on 120 days, in the nuclear magnetic resonance, NMR check of the total institute of Taiyuan Iron and Steel Co. on August 19, focus disappears substantially, and the state of an illness is recovered substantially, follows up a case by regular visits to and does not reaccess in 6 months.
Example 10, swim certain, man, 37 years old, on October 7th, 2005 morbidity, Changzhi City medical college diagnosis of spiral CT is lacunar infarction and subarachnoid hemorrhage (about 20ml), admission number: 10233.Their early stage intravenous drip etamsylate, hemostatic enzyme, later stage intravenous drip fourth lattice ground that, nourishing brain, MAILUONING, the state of an illness slightly take a favorable turn.Thereafter long-term oral aspirin, Radix Salviae Miltiorrhizae drop pill, network are glad logical, and the state of an illness slightly increases the weight of again gradually.On February 24th, 2006, patient's stringy pulse is floating, and is loud unable, the bluish lip crimson tongue, thick fur is yellow greasy, flushed cheeks conjunctival congestion, right hemiplegia, walking and language function forfeiture, take this invention medicine, sooner or later respectively obey a bag after meal every day, and warm water send down, diet: raw and cold, pungent, seafood, wine and greasy food.Take medicine to the 10th day produce effects, after 40 days walking as usual, language function recovers after 80 days, but has unfavorablely slightly, take medicine to 120 recoveries from illness, blood pressure stabilization (remaining on 130/85mmhg), the CT of the People's Hospital, Taiyuan City is multiple, the head structure is normal, each ventricles of the brain, encephalocoele no abnormality seen.Follow up a case by regular visits to not recurrence in 1 year.
Example 11, Zhao, woman, 46 years old, second Affiliated Hospital of University Of Shanxi is diagnosed as congenital heart disease, and the room lacks (secondary pass lack the about 4.7cm in hole), right ventricular hypertrophy, the Tricuspid valve amount of returning (middle amount), pulmonary hypertension, the Bicuspid valve point thickens, a small amount of hydrops of pericardium, admission number: 111023.The long-term oral aspirin of this patient, Radix Salviae Miltiorrhizae drop pill, network are glad logical, WENXIN KELI, BUCHANG NAOXINTONG, and regularly intravenous drip Herba Asari oil lamp injection, Radix Astragali injection, MAILUONING, the state of an illness is more and more heavier, bluish complexion simple and unadorned, the purple lip crimson tongue, binocular is dull, dizzy nauseating, weak and limp dyspnea with rapid respiration, anasarca, the weak number of stringy pulse floating pulse was unable when December was gone to a doctor on the 24th in 2006, and diet does not advance.Begin with the bupleurum root decoction plus-minus, virus throws off a cold after 5 days; Obey 10 doses of plus-minus Liujunzi Tangs again with the spleen and stomach regulating.Subsequently, obey medicine of the present invention, sooner or later respectively obey a bag after meal every day, gets Radix Astragali 5g, Radix Angelicae Sinensis 5g fries in shallow oil water delivery service, diet: raw and cold, pungent, seafood, wine and greasy food.The color ultrasound of taking medicine to 40 days once more check, secondary lack the hole and are reduced into 3.5cm by 4.7cm; Taking medicine to 80 days all diseases all disappears, and secondary lacks the hole and is reduced into 2.8cm again; Take medicine to recovery from illness in 120 days, continue to dwindle but the heart secondary lacks Kong Weijian, it is as usual to live.
Example 12, Zhao, man, 36 years old, on January 3rd, 2008, because of chest pain, general weakness is gone to a doctor to big second Affiliated Hospital of Shanxi medical courses in general, and nuclear magnetic resonance diagnosis is the serious symptom heart infarction, sinus bradycardia, incomplete right bundle-branch block admission number: 198891.Intravenous drip fructose, cephalosporin, Energy mixture, MAILUONING, oral aspirin, Radix Salviae Miltiorrhizae drop pill are alleviated behind the first quarter moon and are left hospital.Send out after ten days, except that above-mentioned symptom, and it is frightened and restless to hold concurrently, and can not fall asleep again.Deep-slow pulse, the purple flushed cheeks of face, the bluish lip crimson tongue, tongue can not go out, and the tip of the tongue curls to left down, and vibration is more than.On January 28th, 2008, oral medicine of the present invention was sooner or later respectively obeyed a bag after meal, Ramulus et folium taxi cuspidatae 3g, Herb Gynostemmae Pentaphylli 2g, diet: raw and cold, pungent, seafood, wine and greasy food.Pain relief after taking medicine 12 hours, pain disappears after taking medicine 20, after taking medicine 80 days healthy and strong as before, can normally participate in field labour, taking medicine circles round to 120 days People's Hospital of Shanxi Prov. nuclear magnetic resonance check heart right sides blocks complete obiteration.
Above-described embodiment is described preferred implementation of the present invention; be not that scope of the present invention is limited; design under the prerequisite of spirit not breaking away from the present invention; various distortion and improvement that the common engineers and technicians in this area make technical scheme of the present invention all should fall in the definite protection domain of claims of the present invention.
Claims (6)
1, a kind of medicine that is used for the treatment of cardiovascular and cerebrovascular disease and sequela thereof is characterized in that, makes Radix Notoginseng by following parts by weight of traditional Chinese medicines crude drug: 120-140; Pheretima: 100-120; Hirudo: 100-120; The Radix Astragali: 120-150; Rhizoma Chuanxiong: 60-90; Flos Carthami: 60-90; Semen Persicae 120-140; Radix Salviae Miltiorrhizae: 90-120; Margarita: 110-130.
2, according to the described medicine that is used for the treatment of cardiovascular and cerebrovascular disease and sequela thereof of claim 1, it is characterized in that, make by following parts by weight of traditional Chinese medicines crude drug:
Radix Notoginseng: 130-140; Pheretima: 110-120; Hirudo: 110-120; The Radix Astragali: 130-140; Rhizoma Chuanxiong: 80-90; Flos Carthami: 70-90; Semen Persicae 120-130; Radix Salviae Miltiorrhizae: 90-110; Margarita: 110-120.
3, according to the described medicine that is used for the treatment of cardiovascular and cerebrovascular disease and sequela thereof of claim 2, it is characterized in that: the raw material of Chinese medicine medicine by following weight is made:
Radix Notoginseng: 140 grams, Pheretima: 110 grams, Hirudo: 114 grams, the Radix Astragali: 132 grams, Rhizoma Chuanxiong: 85 grams, Flos Carthami: 86 grams, Semen Persicae 130 grams, Radix Salviae Miltiorrhizae: 110 grams, Margarita: 110 grams.
4, according to any described medicine that is used for the treatment of cardiovascular and cerebrovascular disease and sequela thereof of claim 1-3, it is characterized in that: its dosage form is a pill.
5, the described preparation method that is used for the treatment of the medicine of cardiovascular and cerebrovascular disease and sequela thereof of claim 4, it is characterized in that: each medicine is mixed in the prescription ratio, be processed into fine powder, again according to the mixed of weight ratio 3:1 evenly and make the pill of 1 to 3 millimeter of diameter, also oven dry of 100 ℃ of sterilizations of reuse high-temperature sterilization case with above-mentioned medicated powder and Mel.
6, preparation method according to claim 5 is characterized in that: after 100 ℃ of sterilization of high-temperature sterilization case and drying, and per 12 grams of dried pill one bag, plastic packaging, per 40 bags are portion, vacuum packaging.
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