CN110559356A - a Chinese medicinal composition for treating cardiovascular diseases, and its preparation method - Google Patents
a Chinese medicinal composition for treating cardiovascular diseases, and its preparation method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention provides a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof, relating to the technical field of traditional Chinese medicines and comprising the following raw materials in parts by weight: 80-100 parts of salvia miltiorrhiza, 100-120 parts of astragalus, 60-80 parts of pubescent holly root, 50-60 parts of ligusticum wallichii, 40-50 parts of leech, 15-20 parts of peach kernel, 15-20 parts of safflower, 25-30 parts of pseudo-ginseng and 8-10 parts of borneol. The formula is based on the theory of traditional Chinese medicine, follows the principle of monarch, minister, assistant and guide dialectical treatment, and the traditional Chinese medicine raw materials are mutually compatible and complement to each other, so that the formula has the function of synergy, can treat both symptoms and root causes, has obvious effect on treating cardiovascular diseases, adopts different treatment and extraction methods aiming at different traditional Chinese medicines in the preparation process, can maximally exert the effects of the raw materials, avoids waste and reduces the cost.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof.
background
Cardiovascular and cerebrovascular diseases are the general names of cardiovascular and cerebrovascular diseases, and generally refer to ischemic or hemorrhagic diseases of heart, brain and systemic tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, hypertension and the like. The cardiovascular and cerebrovascular diseases are common diseases seriously threatening the health of human beings, particularly the middle-aged and old people over 50 years old, have the characteristics of high morbidity, high disability rate and high mortality, even if the most advanced and perfect treatment means at present are applied, more than 50 percent of cerebrovascular accident survivors can not completely take care of the life, the number of people dying from the cardiovascular and cerebrovascular diseases in each year in the world reaches 1500 thousands, and the people live at the first of various causes of death. The etiology is mainly divided into 4 aspects: vascular factors such as atherosclerosis, hypertensive arteriosclerotic disease and arteritis; blood flow dynamics factors such as hypertension; dyshemorheology such as hyperlipidemia and diabetes; blood component factors such as leukemia, anemia and thrombocytosis. The common symptoms are: palpitation, shortness of breath, orthopnea, nocturnal paroxysmal dyspnea, compression or tightness pain behind the sternum, chest tightness and discomfort, edema, cyanosis, syncope, cough and hemoptysis, weakness, belch, epigastric pain, nausea, vomiting; left back pain, left arm pain, etc.
at present, the treatment means for the cardiovascular and cerebrovascular diseases is generally western medicines, the adopted traditional western medicines mainly comprise nitrates, beta-receptor blockers, calcium antagonists and the like, the western medicines have quick response but have larger toxic and side effects, and the western medicines can cause different degrees of damage to blood vessels and human organs after long-term use.
Disclosure of Invention
technical problem to be solved
aiming at the defects of the prior art, the invention provides the traditional Chinese medicine composition for treating cardiovascular diseases and the preparation method thereof.
(II) technical scheme
in order to achieve the purpose, the invention is realized by the following technical scheme:
a traditional Chinese medicine composition for treating cardiovascular diseases comprises the following raw materials in parts by weight: 80-100 parts of salvia miltiorrhiza, 100-120 parts of astragalus, 60-80 parts of pubescent holly root, 50-60 parts of ligusticum wallichii, 40-50 parts of leech, 15-20 parts of peach kernel, 15-20 parts of safflower, 25-30 parts of pseudo-ginseng and 8-10 parts of borneol.
preferably, the feed comprises the following raw materials in parts by weight: 85-95 parts of salvia miltiorrhiza, 105-115 parts of astragalus, 65-75 parts of pubescent holly root, 52-57 parts of ligusticum wallichii, 43-46 parts of leech, 16-18 parts of peach kernel, 16-18 parts of safflower, 26-29 parts of pseudo-ginseng and 9-10 parts of borneol.
Preferably, the feed comprises the following raw materials in parts by weight: 90 parts of salvia miltiorrhiza, 110 parts of astragalus, 70 parts of pubescent holly root, 55 parts of ligusticum wallichii, 44 parts of leech, 17 parts of peach kernel, 16 parts of safflower, 28 parts of pseudo-ginseng and 10 parts of borneol.
preferably, the feed comprises the following raw materials in parts by weight: 88 parts of salvia miltiorrhiza, 112 parts of astragalus, 73 parts of pubescent holly root, 54 parts of ligusticum wallichii, 46 parts of leech, 17 parts of peach kernel, 16 parts of safflower, 27 parts of pseudo-ginseng and 9 parts of borneol.
Preferably, the feed comprises the following raw materials in parts by weight: 93 parts of salvia miltiorrhiza, 107 parts of astragalus, 66 parts of pubescent holly root, 56 parts of ligusticum wallichii, 45 parts of leech, 18 parts of peach kernel, 17 parts of safflower, 26 parts of pseudo-ginseng and 10 parts of borneol.
The preparation method of the traditional Chinese medicine composition for treating cardiovascular diseases comprises the following steps:
1) Weighing the traditional Chinese medicine raw materials according to a proportion, crushing the ligusticum wallichii, the leech, the peach kernel and the borneol, and sieving the crushed materials by a 280-320 mesh sieve to obtain fine powder for later use;
2) Adding water 12-14 times the total weight of radix Ilicis Pubescentis, Carthami flos and Notoginseng radix, decocting for 2-4 hr to obtain primary filtrate and residue, adding water 6-8 times the total weight of the residue, decocting for 1-2 hr, filtering to obtain secondary filtrate, mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain extract;
3) adding 80% ethanol 8-10 times of the total weight of Saviae Miltiorrhizae radix and radix astragali, reflux-extracting for 2-4 hr, filtering to obtain primary filtrate and residue, adding 50% ethanol 4-6 times of the total weight of the residue, reflux-extracting for 1-3 hr to obtain secondary filtrate and residue, mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain extract;
4) mixing the fine powder prepared in the step 1) with the extract prepared in the step 2) and the step 3), adding pharmaceutically acceptable auxiliary materials, and preparing into a pill dosage form to obtain the traditional Chinese medicine composition.
In the invention, the traditional Chinese medicine raw materials have the following effects:
Red sage root: has the effects of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood and eliminating carbuncle;
Astragalus root: has effects in invigorating qi, consolidating superficial resistance, promoting urination, tonifying heart, lowering blood pressure, inhibiting bacteria, removing toxic materials, promoting pus discharge, promoting granulation, enhancing capillary resistance, and relieving sweating and sex hormone;
Pubescent holly root: has effects of clearing away heat and toxic materials, promoting blood circulation, and dredging collaterals, and can be used for treating thromboangiitis obliterans, coronary heart disease, hemiplegia caused by cerebrovascular accident, etc.;
Ligusticum wallichii: has effects in promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, and relieving pain, and can be used for treating headache due to wind, and rheumatalgia;
leech: has certain degree of increasing effect on myocardial trophism blood flow, protecting tissue ischemia and anoxia, dilating capillary vessel, improving microcirculation, and increasing kidney blood flow;
Peach kernel: has effects of promoting blood circulation, dispelling blood stasis, loosening bowel to relieve constipation, relieving cough and asthma;
Safflower: has effects in promoting blood circulation, dispelling blood stasis, eliminating dampness, and relieving swelling;
Pseudo-ginseng: has effects in dispelling blood stasis, stopping bleeding, relieving swelling, and relieving pain;
Borneol: has effects of inducing resuscitation, refreshing mind, clearing heat, removing toxic substances, improving eyesight, and removing nebula.
(III) advantageous effects
the invention provides a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof, the formula is based on the theory of traditional Chinese medicine, follows the principle of monarch, minister, assistant and guide dialectical treatment, and the traditional Chinese medicine raw materials are mutually compatible and complement to each other, so that the traditional Chinese medicine composition has the synergistic effect, treats both principal and secondary aspect of disease, has obvious effect on treating cardiovascular diseases, adopts different treatment and extraction methods aiming at different traditional Chinese medicines in the preparation process, can maximally exert the effects of the raw materials, avoids waste and reduces the cost.
Detailed Description
in order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
example 1:
a traditional Chinese medicine composition for treating cardiovascular diseases comprises the following raw materials in parts by weight: 80 parts of salvia miltiorrhiza, 115 parts of astragalus, 60 parts of pubescent holly root, 57 parts of ligusticum wallichii, 40 parts of leech, 18 parts of peach kernel, 15 parts of safflower, 29 parts of pseudo-ginseng and 8 parts of borneol.
the preparation method of the traditional Chinese medicine composition for treating cardiovascular diseases comprises the following steps:
1) weighing the traditional Chinese medicine raw materials according to a proportion, crushing the ligusticum wallichii, the leech, the peach kernel and the borneol, and sieving the crushed materials with a 320-mesh sieve to obtain fine powder for later use;
2) Adding water 14 times the total weight of radix Ilicis Pubescentis, Carthami flos and Notoginseng radix, decocting for 4 hr to obtain primary filtrate and residue, adding water 8 times the total weight of the residue, decocting for 1 hr, filtering to obtain secondary filtrate, mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain extract;
3) Adding 80% ethanol 9 times of the total weight of Saviae Miltiorrhizae radix and radix astragali, reflux-extracting for 3 hr, filtering to obtain primary filtrate and residue, adding 50% ethanol 5 times of the total weight of the residue, reflux-extracting for 3 hr to obtain secondary filtrate and residue, mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain extract;
4) mixing the fine powder prepared in the step 1) with the extract prepared in the step 2) and the step 3), adding pharmaceutically acceptable auxiliary materials, and preparing into a pill dosage form to obtain the traditional Chinese medicine composition.
example 2:
a traditional Chinese medicine composition for treating cardiovascular diseases comprises the following raw materials in parts by weight: 100 parts of salvia miltiorrhiza, 105 parts of astragalus, 80 parts of pubescent holly root, 52 parts of ligusticum wallichii, 50 parts of leech, 16 parts of peach kernel, 20 parts of safflower, 26 parts of pseudo-ginseng and 10 parts of borneol.
the preparation method of the traditional Chinese medicine composition for treating cardiovascular diseases comprises the following steps:
1) Weighing the traditional Chinese medicine raw materials according to a proportion, crushing the ligusticum wallichii, the leech, the peach kernel and the borneol, and sieving the crushed materials with a 280-mesh sieve to obtain fine powder for later use;
2) Adding water 12 times the total weight of radix Ilicis Pubescentis, Carthami flos and Notoginseng radix, decocting for 2 hr to obtain primary filtrate and residue, adding water 7 times the total weight of the residue, decocting for 2 hr, filtering to obtain secondary filtrate, mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain extract;
3) Adding 80% ethanol 10 times of the total weight of Saviae Miltiorrhizae radix and radix astragali, reflux-extracting for 4 hr, filtering to obtain primary filtrate and residue, adding 50% ethanol 6 times of the total weight of the residue, reflux-extracting for 1 hr to obtain secondary filtrate and residue, mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain extract;
4) mixing the fine powder prepared in the step 1) with the extract prepared in the step 2) and the step 3), adding pharmaceutically acceptable auxiliary materials, and preparing into a pill dosage form to obtain the traditional Chinese medicine composition.
Example 3:
a traditional Chinese medicine composition for treating cardiovascular diseases comprises the following raw materials in parts by weight: 85 parts of salvia miltiorrhiza, 120 parts of astragalus, 65 parts of pubescent holly root, 60 parts of ligusticum wallichii, 43 parts of leech, 20 parts of peach kernel, 16 parts of safflower, 30 parts of pseudo-ginseng and 9 parts of borneol.
The preparation method of the traditional Chinese medicine composition for treating cardiovascular diseases comprises the following steps:
1) Weighing the traditional Chinese medicine raw materials according to a proportion, crushing the ligusticum wallichii, the leech, the peach kernel and the borneol, and sieving the crushed materials with a 300-mesh sieve to obtain fine powder for later use;
2) adding water 13 times the total weight of radix Ilicis Pubescentis, Carthami flos and Notoginseng radix, decocting for 3 hr to obtain primary filtrate and residue, adding water 6 times the total weight of the residue, decocting for 2 hr, filtering to obtain secondary filtrate, mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain extract;
3) Adding 80% ethanol 8 times of the total weight of Saviae Miltiorrhizae radix and radix astragali, reflux-extracting for 2h, filtering to obtain primary filtrate and residue, adding 50% ethanol 4 times of the total weight of the residue, reflux-extracting for 2h to obtain secondary filtrate and residue, mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain extract;
4) mixing the fine powder prepared in the step 1) with the extract prepared in the step 2) and the step 3), adding pharmaceutically acceptable auxiliary materials, and preparing into a pill dosage form to obtain the traditional Chinese medicine composition.
example 4:
A traditional Chinese medicine composition for treating cardiovascular diseases comprises the following raw materials in parts by weight: 95 parts of salvia miltiorrhiza, 100 parts of astragalus, 75 parts of pubescent holly root, 50 parts of ligusticum wallichii, 46 parts of leech, 15 parts of peach kernel, 18 parts of safflower, 25 parts of pseudo-ginseng and 10 parts of borneol. The preparation method is the same as that of example 1.
Example 5:
a traditional Chinese medicine composition for treating cardiovascular diseases comprises the following raw materials in parts by weight: 90 parts of salvia miltiorrhiza, 110 parts of astragalus, 70 parts of pubescent holly root, 55 parts of ligusticum wallichii, 44 parts of leech, 17 parts of peach kernel, 16 parts of safflower, 28 parts of pseudo-ginseng and 10 parts of borneol. The preparation method is the same as that of example 1.
example 6:
A traditional Chinese medicine composition for treating cardiovascular diseases comprises the following raw materials in parts by weight: 88 parts of salvia miltiorrhiza, 112 parts of astragalus, 73 parts of pubescent holly root, 54 parts of ligusticum wallichii, 46 parts of leech, 17 parts of peach kernel, 16 parts of safflower, 27 parts of pseudo-ginseng and 9 parts of borneol. The preparation method is the same as that of example 1.
Example 7:
A traditional Chinese medicine composition for treating cardiovascular diseases comprises the following raw materials in parts by weight: 91 parts of salvia miltiorrhiza, 102 parts of astragalus, 74 parts of pubescent holly root, 55 parts of ligusticum wallichii, 45 parts of leech, 16 parts of peach kernel, 17 parts of safflower, 29 parts of pseudo-ginseng and 10 parts of borneol. The preparation method is the same as that of example 1.
example 8:
A traditional Chinese medicine composition for treating cardiovascular diseases comprises the following raw materials in parts by weight: 93 parts of salvia miltiorrhiza, 107 parts of astragalus, 66 parts of pubescent holly root, 56 parts of ligusticum wallichii, 45 parts of leech, 18 parts of peach kernel, 17 parts of safflower, 26 parts of pseudo-ginseng and 10 parts of borneol. The preparation method is the same as that of example 1.
The clinical application is as follows:
1. Case conditions: outpatient and hospitalized cases were counted, and 240 patients with cardiovascular disease were treated with the average age of 58 years. The patients all suffer from symptoms of palpitation, short breath, chest distress and discomfort, syncope, cough and hemoptysis, weakness, eructation, epigastric pain, nausea, vomiting and the like with different degrees, and are diagnosed as cardiovascular diseases according to the traditional Chinese medicine syndrome diagnosis standard. Patients are randomly divided into 8 groups, each group contains 30 patients, the traditional Chinese medicine composition prepared in the embodiment 1-8 is respectively taken once in the morning and at night, 10 days is a treatment course, and the effect is observed after the traditional Chinese medicine composition is taken for two treatment courses.
2. the evaluation standard of curative effect is as follows: according to the guiding principle of clinical research of cardiovascular diseases in the process of new traditional Chinese medicine treatment, the judgment standard of the traditional Chinese medicine syndrome curative effect is as follows:
and (3) curing: the clinical symptoms and physical signs of the traditional Chinese medicine disappear or basically disappear;
the effect is shown: the clinical symptoms and physical signs of the traditional Chinese medicine are obviously improved;
The method has the following advantages: the clinical symptoms and physical signs of the traditional Chinese medicine are improved;
and (4) invalidation: the clinical symptoms and physical signs of the traditional Chinese medicine are not obviously improved or aggravated.
3. The clinical treatment results are shown in table 1.
table 1:
In summary, the embodiment of the invention has the following beneficial effects: the traditional Chinese medicine composition prepared in the embodiments 1 to 8 of the invention has obvious curative effect on treating cardiovascular diseases, and the total effective rate of treatment can reach 92.5%.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (6)
1. the traditional Chinese medicine composition for treating cardiovascular diseases is characterized by comprising the following raw materials in parts by weight: 80-100 parts of salvia miltiorrhiza, 100-120 parts of astragalus, 60-80 parts of pubescent holly root, 50-60 parts of ligusticum wallichii, 40-50 parts of leech, 15-20 parts of peach kernel, 15-20 parts of safflower, 25-30 parts of pseudo-ginseng and 8-10 parts of borneol.
2. the traditional Chinese medicine composition for treating cardiovascular diseases according to claim 1, which comprises the following raw materials in parts by weight: 85-95 parts of salvia miltiorrhiza, 105-115 parts of astragalus, 65-75 parts of pubescent holly root, 52-57 parts of ligusticum wallichii, 43-46 parts of leech, 16-18 parts of peach kernel, 16-18 parts of safflower, 26-29 parts of pseudo-ginseng and 9-10 parts of borneol.
3. the traditional Chinese medicine composition for treating cardiovascular diseases according to claim 2, which comprises the following raw materials in parts by weight:
90 parts of salvia miltiorrhiza, 110 parts of astragalus, 70 parts of pubescent holly root, 55 parts of ligusticum wallichii, 44 parts of leech, 17 parts of peach kernel, 16 parts of safflower, 28 parts of pseudo-ginseng and 10 parts of borneol.
4. the traditional Chinese medicine composition for treating cardiovascular diseases according to claim 2, which comprises the following raw materials in parts by weight:
88 parts of salvia miltiorrhiza, 112 parts of astragalus, 73 parts of pubescent holly root, 54 parts of ligusticum wallichii, 46 parts of leech, 17 parts of peach kernel, 16 parts of safflower, 27 parts of pseudo-ginseng and 9 parts of borneol.
5. the traditional Chinese medicine composition for treating cardiovascular diseases according to claim 2, which comprises the following raw materials in parts by weight:
93 parts of salvia miltiorrhiza, 107 parts of astragalus, 66 parts of pubescent holly root, 56 parts of ligusticum wallichii, 45 parts of leech, 18 parts of peach kernel, 17 parts of safflower, 26 parts of pseudo-ginseng and 10 parts of borneol.
6. The method for preparing a Chinese medicinal composition for treating cardiovascular diseases according to any one of claims 1 to 5, comprising the steps of:
1) weighing the traditional Chinese medicine raw materials according to a proportion, crushing the ligusticum wallichii, the leech, the peach kernel and the borneol, and sieving the crushed materials by a 280-320 mesh sieve to obtain fine powder for later use;
2) adding water 12-14 times the total weight of radix Ilicis Pubescentis, Carthami flos and Notoginseng radix, decocting for 2-4 hr to obtain primary filtrate and residue, adding water 6-8 times the total weight of the residue, decocting for 1-2 hr, filtering to obtain secondary filtrate, mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain extract;
3) Adding 80% ethanol 8-10 times of the total weight of Saviae Miltiorrhizae radix and radix astragali, reflux-extracting for 2-4 hr, filtering to obtain primary filtrate and residue, adding 50% ethanol 4-6 times of the total weight of the residue, reflux-extracting for 1-3 hr to obtain secondary filtrate and residue, mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain extract;
4) mixing the fine powder prepared in the step 1) with the extract prepared in the step 2) and the step 3), adding pharmaceutically acceptable auxiliary materials, and preparing into a pill dosage form to obtain the traditional Chinese medicine composition.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1977908A (en) * | 2006-12-20 | 2007-06-13 | 北京润德康医药技术有限公司 | Chinese medicine composition for treating cardio-cerebrovascular disease |
| CN101085021A (en) * | 2006-06-08 | 2007-12-12 | 天津天士力制药股份有限公司 | Medicinal composition containing safflower and radix astragali, preparation method and preparation |
| CN101507765A (en) * | 2009-03-24 | 2009-08-19 | 杜枭非 | Medicine for treating cerebrovascular disease and sequela thereof and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085021A (en) * | 2006-06-08 | 2007-12-12 | 天津天士力制药股份有限公司 | Medicinal composition containing safflower and radix astragali, preparation method and preparation |
| CN1977908A (en) * | 2006-12-20 | 2007-06-13 | 北京润德康医药技术有限公司 | Chinese medicine composition for treating cardio-cerebrovascular disease |
| CN101507765A (en) * | 2009-03-24 | 2009-08-19 | 杜枭非 | Medicine for treating cerebrovascular disease and sequela thereof and preparation method thereof |
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Application publication date: 20191213 |