CN104138502A - Traditional Chinese medicine compound for treating ovarian tumors and preparation method and application thereof - Google Patents
Traditional Chinese medicine compound for treating ovarian tumors and preparation method and application thereof Download PDFInfo
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- CN104138502A CN104138502A CN201410365960.8A CN201410365960A CN104138502A CN 104138502 A CN104138502 A CN 104138502A CN 201410365960 A CN201410365960 A CN 201410365960A CN 104138502 A CN104138502 A CN 104138502A
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Abstract
The invention discloses a traditional Chinese medicine compound for treating ovarian tumors. The compound comprises the following raw materials of, by weight, 12-18 parts of red peony roots, 12-18 parts of white peony roots, 12-18 parts of salvia, 8-12 parts of anemarrhenae, 8-12 parts of phellodendron, 4-8 parts of charred hair, 20-25 parts of spiny jujubes, 8-10 parts of spring bupleurum, 12-18 parts of astragalus, 8-12 parts of epimediums, 12-18 parts of clematis, 8-12 parts of fructus psoraleae and 6-10 parts of Szechuan lovage rhizomes. Compared with the prior art, the traditional Chinese medicine compound for treating the ovarian tumors is reasonable in compatibility, the raw materials have good synergistic effects, the treatment effect is satisfying, life quality of patients is improved, and a preparation method is simple and easy to implement.
Description
Technical field
The present invention relates to Chinese medicine preparation and preparation method thereof, relate in particular to a kind of Chinese medicine composition for the treatment of ovarian tumor and its preparation method and application.
Background technology
Ovarian tumor refers to the tumor betiding on ovary.The highest tumor of mortality rate in malignant tumor of ovary or gynecologic malignant tumor.For malignant tumor, common way is operation, and chemotherapy is large especially to the injury of human body.
Summary of the invention
In order to solve the existing problem of prior art, the invention provides a kind of Chinese medicine composition of eutherapeutic treatment ovarian tumor.
The technical problem that the present invention also will solve is to provide the preparation method of above-mentioned Chinese medicine composition.
The technical problem that the present invention finally will solve is to provide the application of above-mentioned Chinese medicine composition.
For reaching above-mentioned technical problem, the present invention is by the following technical solutions: a kind of Chinese medicine composition for the treatment of ovarian tumor, comprises the crude drug of following parts by weight: Radix Paeoniae Rubra 12-18 part, Radix Paeoniae Alba 12-18 part, Radix Salviae Miltiorrhizae 12-18 part, Rhizoma Anemarrhenae 8-12 part, Cortex Phellodendri 8-12 part, Crinis Carbonisatus 4-8 part, Semen Ziziphi Spinosae 20-25 part, HERBA BUPLEURL 8-10 part, Radix Astragali 12-18 part, Herba Epimedii 8-12 part, Radix Clematidis 12-18 part, Fructus Psoraleae 8-12 part, Rhizoma Chuanxiong 6-10 part.
As a further improvement on the present invention, the crude drug that comprises following parts by weight: 15 parts of Radix Paeoniae Rubra, 15 parts of the Radix Paeoniae Albas, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Cortex Phellodendris, 6 parts of Crinis Carbonisatus, 25 parts of Semen Ziziphi Spinosaes, 10 parts of HERBA BUPLEURLs, 15 parts of the Radixs Astragali, 10 parts of Herba Epimedii, 15 parts of Radix Clematidis, 10 parts of Fructus Psoraleaes, 8 parts of Rhizoma Chuanxiong.
The preparation method of the Chinese medicine composition of above-mentioned treatment ovarian tumor, comprises the steps:
(1) according to parts by weight, take each crude drug; Standby;
(2) all crude drug are added to the soak with ethanol 2-3 hour that volumetric concentration is 60-85%, then reflux, extract, 2-3 hour, filters filtrate for later use;
(3) it is that the ethanol of 60-85% carries out alcohol extraction 1-2 hour that filtering residue step (2) being obtained continues to add volumetric concentration; Filter filtrate for later use;
(4) step (2) and step (3) are obtained to twice filtrate and carry out concentrating under reduced pressure, while being concentrated into 60 ℃, relative density is 1.22-1.25, obtains extractum; Be the Chinese medicine composition for the treatment of ovarian tumor.
In above-mentioned steps (2), the 8-10 of the gross weight that amount of alcohol is each crude drug doubly.
In above-mentioned steps (3), the 6-8 of the gross weight that amount of alcohol is each crude drug doubly.
The application of the Chinese medicine composition of above-mentioned treatment ovarian tumor in preparation ovarian tumor medicine.
Described medicine comprises that the Chinese medicine composition for the treatment of ovarian tumor is combined the various dosage forms made from pharmaceutically acceptable carrier; Described dosage form is liquid preparation and solid preparation.Described liquid preparation is mixture or syrup; Solid preparation is tablet, capsule or granule.
Beneficial effect: compared with prior art, a kind of Chinese medicine composition for the treatment of ovarian tumor provided by the present invention, compatibility is reasonable, has good synergism between each crude drug, and satisfactory effect improves patient's life quality.Preparation method of the present invention is simple, easy operating.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further described: should be understood that, the embodiment of the present invention is only for illustrating the present invention, rather than limit the scope of the invention, after having read the present invention, those skilled in the art all fall within the application's claims limited range to the modification of the various equivalent form of values of the present invention.
Embodiment 1: granule
Treat a Chinese medicine composition for ovarian tumor, comprise the crude drug of following parts by weight: 15 parts of Radix Paeoniae Rubra, 15 parts of the Radix Paeoniae Albas, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Cortex Phellodendris, 6 parts of Crinis Carbonisatus, 25 parts of Semen Ziziphi Spinosaes, 10 parts of HERBA BUPLEURLs, 15 parts of the Radixs Astragali, 10 parts of Herba Epimedii, 15 parts of Radix Clematidis, 10 parts of Fructus Psoraleaes, 8 parts of Rhizoma Chuanxiong.
The preparation method of the Chinese medicine composition of above-mentioned treatment ovarian tumor, comprises the following steps:
(1) according to parts by weight, take each crude drug; Standby;
(2) all crude drug being added to volumetric concentration is 60% soak with ethanol 2.5 hours, and then reflux, extract, is 2.5 hours, filters filtrate for later use; Amount of alcohol is 9 times of gross weight of each crude drug.
(3) it is that 60% ethanol carries out alcohol extraction 1 hour that filtering residue step (2) being obtained continues to add volumetric concentration; Filter filtrate for later use; Amount of alcohol is 7 times of gross weight of each crude drug.
(4) step (2) and step (3) are obtained to twice filtrate and carry out concentrating under reduced pressure, while being concentrated into 60 ℃, relative density is 1.22-1.25, obtains extractum; Add appropriate dextrin, starch, granulate, dry, granulate, subpackage, obtains.
Embodiment 2: tablet
Treat a Chinese medicine composition for ovarian tumor, comprise the crude drug of following parts by weight: 12 parts of Radix Paeoniae Rubra, 12 parts of the Radix Paeoniae Albas, 12 parts of Radix Salviae Miltiorrhizaes, 8 parts of the Rhizoma Anemarrhenaes, 8 parts of Cortex Phellodendris, 4 parts of Crinis Carbonisatus, 20 parts of Semen Ziziphi Spinosaes, 8 parts of HERBA BUPLEURLs, 12 parts of the Radixs Astragali, 8 parts of Herba Epimedii, 12 parts of Radix Clematidis, 8 parts of Fructus Psoraleaes, 6 parts of Rhizoma Chuanxiong.
The preparation method of the Chinese medicine composition of above-mentioned treatment ovarian tumor, comprises the following steps:
(1) according to parts by weight, take each crude drug; Standby;
(2) all crude drug being added to volumetric concentration is 85% soak with ethanol 3 hours, and then reflux, extract, is 2 hours, filters filtrate for later use; Amount of alcohol is 8 times of gross weight of each crude drug.
(3) it is that 85% ethanol carries out alcohol extraction 2 hours that filtering residue step (2) being obtained continues to add volumetric concentration; Filter filtrate for later use; Amount of alcohol is 6 times of gross weight of each crude drug.
(4) step (2) and step (3) are obtained to twice filtrate and carry out concentrating under reduced pressure, while being concentrated into 60 ℃, relative density is 1.22-1.25, obtains extractum; Add appropriate amount of starch, granulate, dry, granulate, coating, subpackage, obtain.
Embodiment 3: syrup
Treat a Chinese medicine composition for ovarian tumor, comprise the crude drug of following parts by weight: 18 parts of Radix Paeoniae Rubra, 18 parts of the Radix Paeoniae Albas, 18 parts of Radix Salviae Miltiorrhizaes, 12 parts of the Rhizoma Anemarrhenaes, 12 parts of Cortex Phellodendris, 8 parts of Crinis Carbonisatus, 25 parts of Semen Ziziphi Spinosaes, 10 parts of HERBA BUPLEURLs, 18 parts of the Radixs Astragali, 12 parts of Herba Epimedii, 18 parts of Radix Clematidis, 12 parts of Fructus Psoraleaes, 10 parts of Rhizoma Chuanxiong.
The preparation method of the Chinese medicine composition of above-mentioned treatment ovarian tumor, comprises the following steps:
(1) according to parts by weight, take each crude drug; Standby;
(2) all crude drug being added to volumetric concentration is 75% soak with ethanol 2 hours, and then reflux, extract, is 3 hours, filters filtrate for later use; Amount of alcohol is 10 times of gross weight of each crude drug.
(3) it is that 75% ethanol carries out alcohol extraction 1.5 hours that filtering residue step (2) being obtained continues to add volumetric concentration; Filter filtrate for later use; Amount of alcohol is 8 times of gross weight of each crude drug.
(4) step (2) and step (3) are obtained to twice filtrate and carry out concentrating under reduced pressure, while being concentrated into 60 ℃, relative density is 1.22-1.25, obtains extractum; Add simple syrup, and adding distil water is to every milliliter of suitable decoction pieces 1g, filters, subpackage, sterilizing, obtains.
By clinical case, further set forth below the beneficial effect of medicine of the present invention:
1, patient's selection: 60 of patients, randomly draw 30 and form test group, remaining is matched group.
2, Therapeutic Method
Test group: the Chinese medicine composition described in embodiment 1-3 in the present invention, sub-service sooner or later.Taking medicine continuously 14 days is 1 course for the treatment of;
Matched group: adopt conventional method treatment.
3, the time: 14 days be 1 course for the treatment of, treat 5 courses for the treatment of.
4, curative effect determinate standard
A) effective: after treating three courses for the treatment of, symptom and sign is clearly better, follow up a case by regular visits to three months tumor markers indexs within normal range;
B) effective: after treating five courses for the treatment of, symptom take a favorable turn; Follow up a case by regular visits to three months tumor markers indexs within normal range;
C) invalid: treat five the course for the treatment of patient's symptom and sign without obviously alleviating, tumor markers index is defective.
(3) clinical effectiveness
Test group and the comparison of matched group curative effect, in Table 1.
Table 1 test group and the comparison of matched group curative effect
Clinical effectiveness shows: test group treatment patients with ovarian tumor, total effective rate reaches 56.7%, compares with matched group total effective rate 30%, is obviously better than matched group.Illustrate that Drug therapy ovarian tumor of the present invention is evident in efficacy, drug effect is remarkable, has good promotional value.
Claims (8)
1. a Chinese medicine composition for the treatment of ovarian tumor, it is characterized in that, comprise the crude drug of following parts by weight: Radix Paeoniae Rubra 12-18 part, Radix Paeoniae Alba 12-18 part, Radix Salviae Miltiorrhizae 12-18 part, Rhizoma Anemarrhenae 8-12 part, Cortex Phellodendri 8-12 part, Crinis Carbonisatus 4-8 part, Semen Ziziphi Spinosae 20-25 part, HERBA BUPLEURL 8-10 part, Radix Astragali 12-18 part, Herba Epimedii 8-12 part, Radix Clematidis 12-18 part, Fructus Psoraleae 8-12 part, Rhizoma Chuanxiong 6-10 part.
2. the Chinese medicine composition for the treatment of ovarian tumor according to claim 1, it is characterized in that, comprise the crude drug of following parts by weight: 15 parts of Radix Paeoniae Rubra, 15 parts of the Radix Paeoniae Albas, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Cortex Phellodendris, 6 parts of Crinis Carbonisatus, 25 parts of Semen Ziziphi Spinosaes, 10 parts of HERBA BUPLEURLs, 15 parts of the Radixs Astragali, 10 parts of Herba Epimedii, 15 parts of Radix Clematidis, 10 parts of Fructus Psoraleaes, 8 parts of Rhizoma Chuanxiong.
3. the preparation method of the Chinese medicine composition for the treatment of ovarian tumor according to claim 1, is characterized in that, comprises the steps:
(1) according to parts by weight, take each crude drug; Standby;
(2) all crude drug are added to the soak with ethanol 2-3 hour that volumetric concentration is 60-85%, then reflux, extract, 2-3 hour, filters filtrate for later use;
(3) it is that the ethanol of 60-85% carries out alcohol extraction 1-2 hour that filtering residue step (2) being obtained continues to add volumetric concentration; Filter filtrate for later use;
(4) step (2) and step (3) are obtained to twice filtrate and carry out concentrating under reduced pressure, while being concentrated into 60 ℃, relative density is 1.22-1.25, obtains extractum; Be the Chinese medicine composition for the treatment of ovarian tumor.
4. the preparation method of the Chinese medicine composition for the treatment of ovarian tumor according to claim 3, is characterized in that: in step (2), the 8-10 of the gross weight that amount of alcohol is each crude drug doubly.
5. the preparation method of the Chinese medicine composition for the treatment of ovarian tumor according to claim 3, is characterized in that: in step (3), the 6-8 of the gross weight that amount of alcohol is each crude drug doubly.
6. the application of the Chinese medicine composition for the treatment of ovarian tumor claimed in claim 1 in preparation ovarian tumor medicine.
7. application according to claim 6, is characterized in that, described medicine comprises that the Chinese medicine composition for the treatment of ovarian tumor is combined the various dosage forms made from pharmaceutically acceptable carrier; Described dosage form is liquid preparation and solid preparation.
8. application according to claim 6, is characterized in that, described liquid preparation is mixture or syrup; Solid preparation is tablet, capsule or granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410365960.8A CN104138502A (en) | 2014-07-29 | 2014-07-29 | Traditional Chinese medicine compound for treating ovarian tumors and preparation method and application thereof |
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| CN201410365960.8A CN104138502A (en) | 2014-07-29 | 2014-07-29 | Traditional Chinese medicine compound for treating ovarian tumors and preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840902A (en) * | 2015-06-09 | 2015-08-19 | 隗伟 | Traditional Chinese medicine preparation for treating ovarian tumor |
| CN111588798A (en) * | 2020-03-11 | 2020-08-28 | 复旦大学附属妇产科医院 | Traditional Chinese medicine compound preparation for improving ovarian hypofunction and preparation method thereof |
-
2014
- 2014-07-29 CN CN201410365960.8A patent/CN104138502A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 何秀兰，等: "《王沛肿瘤治验》", 31 March 2012, 北京科学技术出版社 * |
| 金强: "卵巢癌术后辨证治疗四法", 《山东中医杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840902A (en) * | 2015-06-09 | 2015-08-19 | 隗伟 | Traditional Chinese medicine preparation for treating ovarian tumor |
| CN111588798A (en) * | 2020-03-11 | 2020-08-28 | 复旦大学附属妇产科医院 | Traditional Chinese medicine compound preparation for improving ovarian hypofunction and preparation method thereof |
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Application publication date: 20141112 |