CN104138552A - Application of pharmaceutical composition in preparation of medicaments for treating gastric ulcer - Google Patents
Application of pharmaceutical composition in preparation of medicaments for treating gastric ulcer Download PDFInfo
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Abstract
The invention discloses an application of a pharmaceutical composition in preparation of medicaments for treating gastric ulcer. The pharmaceutical composition is a preparation prepared from the following medicinal raw materials in parts by weight: 17-23 parts of silverweed cinquefoil root, 7-12 parts of poria cocos, 5-9 parts of herba artemisiae, 5-9 parts of pogostemon cablin, 5-9 parts of raw barley sprout, 3-7 parts of magnoliae officinalis cortex, 3-7 parts of perilla leaf and 3-7 parts of caulis perllae. Through specific proportioning of the medicinal raw materials, the pharmaceutical composition disclosed by the invention tastes not very bad, can effectively treat gastric ulcer, and provides a new drug choice for the clinical treatment of peptic ulcer.
Description
Technical field
The present invention relates to the purposes of a kind of pharmaceutical composition in the medicine of preparation treatment gastric ulcer.
Background technology
Stomach refers to the circular or oval full-thickness defects of the limitation of gastric mucosa, and muscularis mucosae is penetrated, and inevitably leaves fibrous scar after healing, and surface is covered by one deck epithelium, and muscularis mucosae can not be regenerated.It is because many reasons causes that gastric acid, pepsin self-digestion or the gastric mucosal barrier to gastric mucosa is destroyed that its cause of disease sums up.Think that in recent years formation and the gastric Helicobacter pylori infection of ulcer also have important relationship.
The medicine of the above-mentioned disease of current treatment mostly is chemical drugs, and it is expensive, and side effect is large, and healing required time is long.Therefore, urgent need one is economical and practical, toxic and side effects is low, and the medicine of the above-mentioned disease of energy rapid healing.
And Chinese medicine aspect treatment of chronic diseases one to all playing an important role.Report, someone uses Os Sepiae (life) 250g, Concha Arcae (calcined) 250g, Radix Et Rhizoma Rhei 200g, Radix Glycyrrhizae Preparata 200g, grind to the powder, boiled water is taken after mixing it with water after meal, each 15g, every day 3～4 times, be used for the treatment of peptic ulcer (Gu Linjiang, Cuttlefish Bone Powder for Peptic Ulcer, journal of shanghai Chinese medicine, 9 phases of calendar year 2001.Also there is people to treat peptic ulcer with Fructus Amomi Rotundus 10g, Rhizoma Atractylodis Macrocephalae 20g, Poria 20g, Herba Pogostemonis 15g, Herba Taraxaci 15g, Radix Ginseng 5g, Folium Perillae 10g, Semen Armeniacae Amarum 10g, Semen Coicis 20g, Herba Artemisiae Scopariae 15g, there is good therapeutic effect.Chinese Patent Application No.: 201310259917.9, disclose a kind of pharmaceutical composition for the treatment of peptic ulcer, its proportioning raw materials is as follows: Radix Rhodiolae 4.2-7.2 part, Poria 14-26 part, Herba Taraxaci 10.5-19.5 part, Herba Artemisiae Scopariae 10.5-19.5 part, Rhizoma Atractylodis Macrocephalae 10.5-19.5 part, Herba Pogostemonis 7-13 part, Fructus Hordei Germinatus 7-13 part, Fructus Amomi Rotundus 3.5-6.5 part.This prescription drug can effectively be treated gastric ulcer, duodenal ulcer and erosive gastritis.
But, patients w ith peptic ulcer disease One's name is legion at present, supply falls short of demand for market medicine, therefore, develops a kind of new pharmaceutical composition that can effectively treat gastric ulcer and seem particularly necessary.
Summary of the invention
The object of the present invention is to provide the purposes of a kind of pharmaceutical composition in the medicine of preparation treatment gastric ulcer.
The invention provides the purposes of pharmaceutical composition as follows in the medicine of preparation treatment gastric ulcer; Described pharmaceutical composition is the preparation being prepared from by the crude drug of following weight proportion:
Radix potentillae anserinae 17-23 part, Poria 7-12 part, Herba Artemisiae Scopariae 5-9 part, Herba Pogostemonis 5-9 part, Fructus Hordei Germinatus 5-9 part, Cortex Magnoliae Officinalis 3-7 part, Folium Perillae 3-7 part, Caulis Perillae 3-7 part.
Further, it is the preparation being prepared from by the crude drug of following weight proportion:
Radix potentillae anserinae 19-21 part, Poria 9-11 part, Herba Artemisiae Scopariae 6-8 part, Herba Pogostemonis 6-8 part, Fructus Hordei Germinatus 6-8 part, Cortex Magnoliae Officinalis 4-6 part, Folium Perillae 4-6 part, Caulis Perillae 4-6 part.
Further, it is the preparation being prepared from by the crude drug of following weight proportion:
20 parts of Radix potentillae anserinae, 10 parts, Poria, 7 parts of Herba Artemisiae Scopariaes, 7 parts of Herba Pogostemonis, 7 parts of Fructus Hordei Germinatus, 5 parts of Cortex Magnoliae Officinalis, 5 parts of Folium Perillae, 5 parts of Caulis Perillaes.
The present invention studies discovery, and under this conditions of mixture ratios, its drug activity is significantly better than other proportionings, and curative effect is clear and definite.
Wherein, it is to be active component by the water of the crude drug of described weight proportion or extractive with organic solvent, adds the preparation that pharmaceutically acceptable adjuvant is prepared from.
Preparation of the present invention is oral formulations, as granule, tablet, powder, decoction, oral liquid, pill etc.
In the present invention, Radix potentillae anserinae (formal name used at school: Potentilla anserina) is the plant of Rosaceae Potentilla.Perennial herb.Radix potentillae anserinae also claims Herba Herminii.Sweet, flat, fill blood, strengthening the spleen and stomach, promoting the production of body fluid to quench thirst, dampness removing.Be used for anemia after being ill, malnutrition, insufficiency of the spleen diarrhoea, rheumatic arthralgia.
Herba Artemisiae Scopariae is that the quadrate part dryly of feverfew Artemisia scoparia Waldst. et Kit. Artemisia scoparia Waldst.Et Kit. or Herba Artemisiae Scopariae Artemisia capillaries Thunb. divides.Bitter, pungent, be slightly cold, return spleen, stomach, liver, gallbladder meridian.Eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice.For jaundice oliguria, hygropyrexia heat-damp in summer, eczema pruritus.
Poria is the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Herba Pogostemonis is that the quadrate part dryly of labiate Herba Pogostemonis Pogostemon cabl in (Blanco) Benth. divides.Pungent, tepor.Return spleen, stomach, lung meridian.Eliminating turbid pathogen with aromatics, and middle preventing or arresting vomiting, deliver expelling summer-heat.For turbid damp obstructing in middle-JIAO, the vomiting of gastral cavity painful abdominal mass, heat-damp in summer exterior syndrome, hygropyrexia is from the beginning of, heating asthenia, uncomfortable in chestly do not relax, and cold-damp is closed summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache.
Folium Perillae is the band branch tender leaf of Labiatae Perilla plant Folium Perillae, and Folium Perillae has expelling cold and relieving exterior syndrome, effect of regulating the flow of QI to ease the stomach, and Folium Perillae cures mainly anemofrigid cold, headache, cough, distension and fullness of the chest and abdomen.
Caulis Perillae is the dry stem of labiate Folium Perillae Perilla frutescens (L.) Britt., regulating the flow of QI to ease the stomach, and pain relieving, antiabortive.Vexed for chest and diaphragm painful abdominal mass, gastralgia, belch vomiting, frequent fetal movement.
Medicine of the present invention is by specific consumption proportion, and flavour of a drug are less, can effectively treat gastric ulcer, selects for clinical treatment peptic ulcer provides a kind of new medication.
Detailed description of the invention
The preparation of embodiment 1 medicine of the present invention
Get Radix potentillae anserinae 20g, Poria 10g, Herba Artemisiae Scopariae 7g, Herba Pogostemonis 7g, Fructus Hordei Germinatus 7g, Cortex Magnoliae Officinalis 5g, Folium Perillae 5g, Caulis Perillae 5g; Add 8 times of water gagings to decoct 3 times, each 10 minutes, filter, merge after decocting liquid, obtain medicine decoction of the present invention.
The preparation of embodiment 2 medicines of the present invention
Get Radix potentillae anserinae 20g, Poria 10g, Herba Artemisiae Scopariae 7g, Herba Pogostemonis 7g, Fructus Hordei Germinatus 7g, Cortex Magnoliae Officinalis 5g, Folium Perillae 5g, Caulis Perillae 5g; Decoct with water 3 times, add for the first time 10 times of water gagings and decoct 5 minutes, add for the second time 8 times of water gagings and decoct 10 minutes, add for the third time 8 times of water gagings and decoct 15 minutes, filter, merge after decocting liquid, concentrated, then add proper starch, and granulate, obtain medicinal granule of the present invention.
The preparation of embodiment 3 medicines of the present invention
Radix potentillae anserinae 20g, Poria 10g, Herba Artemisiae Scopariae 7g, Herba Pogostemonis 7g, Fructus Hordei Germinatus 7g, Cortex Magnoliae Officinalis 5g, Folium Perillae 5g, Caulis Perillae 5g; Get other flavour of a drug except Radix potentillae anserinae, first add 10 times of amount 70% alcoholic solution reflux, extract, 1 time, extract 1 hour, filter, filtrate is for subsequent use, and filtering residue again water decocts 2 times, add water 8 times at every turn and measure, decoct 20 minutes at every turn, merge after ethanol extract and decocting liquid, concentrated, add again Radix potentillae anserinae powder, after granulation, then add appropriate magnesium stearate, tabletting, obtains medicinal tablet of the present invention.
Further show beneficial effect of the present invention by concrete test example below.
The screening of test example 1 pharmaceutical composition of the present invention
Get SD rat, male and female half and half fasting is after 12 hours, rats by intraperitoneal injection 3% is anaesthetized without barbital sodium, with the alcohol cotton stick skin of sterilizing, cut abdominal cavity open, in glandular stomach portion, antetheca hole body intersection serosal surface sticks the circular filter paper 30s that soaks into glacial acetic acid, diameter 5mm, repeat 3 times, close abdomen sewing-up cut, be coated with penicillin.Postoperative routine feeding, the 4th day by animal random packet, model group gavage 10mlkg
-1distilled water, positive drug ranitidine group gavage 30mgkg
-1, the each screening group of the present invention 10g crude drug/kg body weight.The 2nd day after grouping starts gastric infusion, administration every day 1 time, and dosage is 10mlkg
-1, continuous 5 days, last administration is de-cervical vertebra execution animal after 12 hours, cut open the belly and get stomach, wash gastric content with normal saline, stomach is fixed in 10% formaldehyde, after 15 minutes, stomach is lain on glass surface ware, under magnifier, measure major diameter and the minor axis of ulcer surface with slide gauge, and calculate ulcer surface.
Calculate ulcer inhibition rate: ulcer inhibition rate=(matched group ulcer area-administration group ulcer area)/matched group ulcer area x100%, observes ulcer healing degree.
Experimental result is in table 1.
Table 1
Wherein, the compatibility of each screening group is as follows:
Group 1: Radix potentillae anserinae 5g, Poria 10g, Herba Artemisiae Scopariae 10g, Herba Pogostemonis 10g, Fructus Hordei Germinatus 10g, Cortex Magnoliae Officinalis 8g, Folium Perillae 8g, Caulis Perillae 8g;
Group 2: Radix potentillae anserinae 10g, Poria 8g, Herba Artemisiae Scopariae 8g, Herba Pogostemonis 8g, Fructus Hordei Germinatus 8g, Cortex Magnoliae Officinalis 5g, Folium Perillae 5g, Caulis Perillae 5g;
Group 3: Radix potentillae anserinae 15g, Poria 7g, Herba Artemisiae Scopariae 7g, Herba Pogostemonis 7g, Fructus Hordei Germinatus 7g, Cortex Magnoliae Officinalis 5g, Folium Perillae 5g, Caulis Perillae 5g;
Group 4: Radix potentillae anserinae 20g, Poria 10g, Herba Artemisiae Scopariae 7g, Herba Pogostemonis 7g, Fructus Hordei Germinatus 7g, Cortex Magnoliae Officinalis 5g, Folium Perillae 5g, Caulis Perillae 5g.
Above-mentioned each group of compound recipe, flavour of a drug are identical, but medical material consumption proportion difference has appreciable impact to the drug activity of compound recipe: group 1-3, all the gastric ulcer of animal pattern is had to certain inhibitory action, but it is not remarkable to suppress activity; But the prescription proportioning of employing group 4, can significantly improve the therapeutic activity of compound medicine, is significantly better than other each proportioning groups, therefore, the prescription proportioning of preferred group 4 of the present invention.Above-mentioned test shows, pharmaceutical composition of the present invention, under specific proportioning, has been brought into play synergistic function.
The therapeutical effect of test example 2 pharmaceutical composition of the present invention to acetic acid type gastric ulcer
Get SD rat, fasting is after 12 hours, and rats by intraperitoneal injection 3% is anaesthetized without barbital sodium, with the alcohol cotton stick skin of sterilizing, cut abdominal cavity open, in glandular stomach portion, antetheca hole body intersection serosal surface sticks the circular filter paper 30s that soaks into glacial acetic acid, diameter 5mm, repeat 3 times, close abdomen sewing-up cut, be coated with penicillin.Postoperative routine feeding, is divided into 6 groups at random by animal on the 4th day, and 10 every group, male and female half and half, are respectively model group (10mlkg
-1distilled water), pharmaceutical composition of the present invention senior middle school low dose group (be followed successively by 10,20,40g crude drug/kg body weight), contrast groups A (10g crude drug/kg body weight), contrast groups B (10g crude drug/kg body weight), positive drug ranitidine group (30mgkg
-1).The 2nd day after grouping starts gastric infusion, administration every day 1 time, and dosage is 10mlkg
-1, continuous 5 days, last administration is de-cervical vertebra execution animal after 12 hours, cut open the belly and get stomach, wash gastric content with normal saline, stomach is fixed in 10% formaldehyde, after 15 minutes, stomach is lain on glass surface ware, under magnifier, measure major diameter and the minor axis of ulcer surface with slide gauge, and calculate ulcer surface.
Calculate ulcer inhibition rate: ulcer inhibition rate=(matched group ulcer area-administration group ulcer area)/matched group ulcer area x100%, observes ulcer healing degree.
Pharmaceutical composition of the present invention is prepared by embodiment 1;
The preparation method of contrast groups A medicine is as follows:
Get Fructus Amomi Rotundus 10g, Rhizoma Atractylodis Macrocephalae 20g, Poria 20g, Herba Pogostemonis 15g, Herba Taraxaci 15g, Radix Ginseng 5g, Folium Perillae 10g, Semen Armeniacae Amarum 10g, Semen Coicis 20g, Herba Artemisiae Scopariae 15g; Add 8 times of water gagings to decoct 3 times, each 10 minutes, filter, merge decocting liquid, obtain contrast groups A decoction.
The preparation method of contrast groups B medicine is as follows:
Poria 20g, Herba Taraxaci 15g, Herba Artemisiae Scopariae 15g, Rhizoma Atractylodis Macrocephalae 15g, Herba Pogostemonis 10g, Fructus Hordei Germinatus 10g, Radix Rhodiolae 6g, Fructus Amomi Rotundus 5g.Add 8 times of water gagings to decoct 3 times, each 10 minutes, filter, merge decocting liquid, obtain contrast groups B decoction.
Experimental result is in table 2.
Table 2
Note: compared with model group, * is p < 0.05, expects for p < 0.01; Compared with contrast groups A, Δ is p < 0.05, and Δ Δ is p < 0.01; Compared with contrast groups B, a is p < 0.05.
As shown in Table 2, pharmaceutical composition of the present invention, can effectively treat gastric ulcer, and meanwhile, compared with contrast groups A, the drug activity of pharmaceutical composition of the present invention under Isodose is obviously better than contrast groups A (p < 0.05).Compared with contrast groups B, the drug activity under Isodose is suitable.
In sum, compatibility of drugs of the present invention is precise and appropriate, and flavour of a drug are less, can effectively treat gastric ulcer, selects for clinical treatment gastric ulcer provides a kind of new medication.
Claims (5)
1. the purposes of pharmaceutical composition as follows in the medicine of preparation treatment gastric ulcer; Described pharmaceutical composition is the preparation being prepared from by the crude drug of following weight proportion:
Radix potentillae anserinae 17-23 part, Poria 7-12 part, Herba Artemisiae Scopariae 5-9 part, Herba Pogostemonis 5-9 part, Fructus Hordei Germinatus 5-9 part, Cortex Magnoliae Officinalis 3-7 part, Folium Perillae 3-7 part, Caulis Perillae 3-7 part.
2. compound according to claim 1, is characterized in that: described pharmaceutical composition is the preparation being prepared from by the crude drug of following weight proportion:
Radix potentillae anserinae 19-21 part, Poria 9-11 part, Herba Artemisiae Scopariae 6-8 part, Herba Pogostemonis 6-8 part, Fructus Hordei Germinatus 6-8 part, Cortex Magnoliae Officinalis 4-6 part, Folium Perillae 4-6 part, Caulis Perillae 4-6 part.
3. compound according to claim 2, is characterized in that: described pharmaceutical composition is the preparation being prepared from by the crude drug of following weight proportion:
20 parts of Radix potentillae anserinae, 10 parts, Poria, 7 parts of Herba Artemisiae Scopariaes, 7 parts of Herba Pogostemonis, 7 parts of Fructus Hordei Germinatus, 5 parts of Cortex Magnoliae Officinalis, 5 parts of Folium Perillae, 5 parts of Caulis Perillaes.
4. according to the compound described in claim 1-3, it is characterized in that: it is to be active component by the water of the crude drug of described weight proportion or extractive with organic solvent, adds the preparation that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
5. according to the preparation described in claim 1-4, it is characterized in that: described preparation is oral formulations.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138551A (en) * | 2014-08-12 | 2014-11-12 | 徐继锋 | Application of pharmaceutical composition in preparation of medicaments for treating duodenal ulcer |
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Non-Patent Citations (4)
| Title |
|---|
| 南京中医药大学编著: "《中药大辞典》", 30 March 2006, 上海科学技术出版社 * |
| 张冰主编: "《临床中药学》", 30 September 2012, 中国中医药出版社 * |
| 徐丹: "消化性溃疡证候、证素分布规律研究", 《中国优秀硕士学位论文全文数据库》 * |
| 谭坚: "抗御缺氧人参果", 《药膳食疗》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138551A (en) * | 2014-08-12 | 2014-11-12 | 徐继锋 | Application of pharmaceutical composition in preparation of medicaments for treating duodenal ulcer |
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