CN105214030A - The purposes of a kind of pharmaceutical composition in the medicine of preparation treatment gastric ulcer - Google Patents
The purposes of a kind of pharmaceutical composition in the medicine of preparation treatment gastric ulcer Download PDFInfo
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Abstract
The invention provides the purposes of following pharmaceutical composition in the medicine of preparation treatment gastric ulcer; This pharmaceutical composition be the preparation be prepared from by the crude drug of following weight proportion: Rhizoma Atractylodis Macrocephalae 7-13 part, Poria 7-13 part, Semen Phaseoli 7-13 part, Radix Astragali 5-10 part, Herba Artemisiae Scopariae 5-10 part, Herba Taraxaci 5-10 part, Semen Armeniacae Amarum 3-7 part, Radix Platycodonis 3-7 part, Herba Pogostemonis 3-7 part, Rhizoma Zingiberis 2-3 part, Radix Ginseng 2-3 part.Pharmaceutical composition of the present invention, after reasonable compatibility, has played synergistic function, effectively can treat gastric ulcer, good analgesic effect, and has good gastric mucosal effect, for clinical application provides a kind of selection newly.
Description
Technical field
The present invention relates to the purposes of a kind of pharmaceutical composition in the medicine of preparation treatment gastric ulcer.
Background technology
Taste-blindness rate refers to the circular or oval full-thickness defects of the limitation of Grastiodudenal mucosa, and muscularis mucosae is penetrated, and inevitably leaves fibrous scar after healing, and surface is covered by one deck epithelium, and muscularis mucosae can not regenerate.It is because many reasons causes gastric acid, pepsin to be destroyed the self-digestion of gastric mucosa or gastric mucosal barrier that its cause of disease sums up.Think that the formation of ulcer and gastric Helicobacter pylori infection also have important relationship in recent years.
Chronic erosive gastritis, also known as gastritis verrucosa or varioliform gastritis generally rarely seen glutted, indigestion symptom such as pantothenic acid, belch, irregularities stomachache after meal.There is multiple excipuliform in Stomach in Patients mucosa, expands folded shape or pimple sample protuberance, diameter 5 ~ 10mm, the visible mucomembranous defect in top or umbilicus sample depression, and there is erosion at center, and protuberance is many without blush around, but the normal erythema similar with size, with gastric antrum, portion is common.
The medicine of the above-mentioned disease of Current therapeutic mostly is chemical drugs, and it is expensive, and side effect is large, and it is long to cure required time.Therefore, urgent need one is economical and practical, toxic and side effects is low, and the medicine of the above-mentioned disease of energy rapid healing.
And Chinese medicine in treatment of chronic diseases one to all playing an important role.Report, with Concha Arcae 75% and Radix Glycyrrhizae 25%, red in pulv, treatment gastric and duodenal ulcers, cure rate reaches 76% (" Chinese medicine voluminous dictionary " second edition, Shanghai science tech publishing house, in March, 2006,548th ~ 549 pages); Also people is had with Os Sepiae (life) 250g, Concha Arcae (calcined) 250g, Radix Et Rhizoma Rhei 200g, Radix Glycyrrhizae Preparata 200g, grinds to the powder, and boiled water is taken after mixing it with water after meal, each 15g, every day 3 ~ 4 times, be used for the treatment of peptic ulcer (Gu Linjiang, Cuttlefish Bone Powder for Peptic Ulcer, journal of shanghai Chinese medicine, phase calendar year 2001 9.Also there is people to treat peptic ulcer with Fructus Amomi Rotundus 10g, Rhizoma Atractylodis Macrocephalae 20g, Poria 20g, Herba Pogostemonis 15g, Herba Taraxaci 15g, Radix Ginseng 5g, Folium Perillae 10g, Semen Armeniacae Amarum 10g, Semen Coicis 20g, Herba Artemisiae Scopariae 15g, there is certain therapeutic effect.In Chinese patent 201110413686.3, provide the pharmaceutical composition of the good treatment peptic ulcer of a kind of drug activity, be prepared from by Semen Coicis 20 parts, Semen Benincasae 20 parts, Herba Artemisiae Scopariae 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Folium Perillae 10 parts, Semen Armeniacae Amarum 10 parts, Semen Lablab Album 10 parts, Semen Myristicae 10 parts, the Radix Astragali 10 parts, Radix Ginseng 5 parts, Fructus Forsythiae 5 parts.
Summary of the invention
The object of the present invention is to provide the purposes of a kind of pharmaceutical composition in the medicine of preparation treatment gastric ulcer.
The invention provides the purposes of following pharmaceutical composition in the medicine of preparation treatment gastric ulcer; This pharmaceutical composition be the preparation be prepared from by the crude drug of following weight proportion:
Rhizoma Atractylodis Macrocephalae 14-26 part, Poria 14-26 part, Semen Phaseoli 14-26 part, Radix Astragali 10.5-19.5 part, Herba Artemisiae Scopariae 10.5-19.5 part, Herba Taraxaci 10.5-19.5 part, Semen Armeniacae Amarum 7-13 part, Radix Platycodonis 7-13 part, Herba Pogostemonis 7-13 part, Rhizoma Zingiberis 3.5-6.5 part, Radix Ginseng 3.5-6.5 part.
Further, this pharmaceutical composition is the preparation be prepared from by the crude drug of following weight proportion:
Rhizoma Atractylodis Macrocephalae 9-11 part, Poria 9-11 part, Semen Phaseoli 9-11 part, Radix Astragali 7-8 part, Herba Artemisiae Scopariae 7-8 part, Herba Taraxaci 7-8 part, Semen Armeniacae Amarum 4-6 part, Radix Platycodonis 4-6 part, Herba Pogostemonis 4-6 part, Rhizoma Zingiberis 2-3 part, Radix Ginseng 2-3 part.
Preferably, this pharmaceutical composition is the preparation be prepared from by the crude drug of following weight proportion:
The Rhizoma Atractylodis Macrocephalae 10 parts, 10 parts, Poria, Semen Phaseoli 10 parts, the Radix Astragali 7.5 parts, Herba Artemisiae Scopariae 7.5 parts, Herba Taraxaci 7.5 parts, Semen Armeniacae Amarum 5 parts, Radix Platycodonis 5 parts, Herba Pogostemonis 5 parts, Rhizoma Zingiberis 2.5 parts, Radix Ginseng 2.5 parts.
In the present invention, Poria is the dry sclerotia of On Polyporaceae Poria Poriacocos (Schw.) Wolf.Sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Semen Phaseoli is the dry mature seed of leguminous plant Semen Phaseoli VignaumbeuataOhwietOhashi or Semen Phaseoli VignaangularisohwietOhashi.Sweet, sour, flat.GUIXIN, small intestine meridian.Inducing diuresis to remove edema, removing toxic substances and promoting pus discharge.For edema distension, beriberi edema, jaundice dark coloured urine, beriberoid pyretic arthralgia, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess.
Herba Taraxaci is Herba Taraxaci TaraxacummongolicumHand.Mazz, alkali ground Herba Taraxaci TaraxacumborealisinenseKitam. or belong to the dry herb of several plants together.Bitter, sweet, cold.Return liver, stomach warp.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Herba Artemisiae Scopariae is that the quadrate part dryly of feverfew Artemisia scoparia Waldst. et Kit. ArtemisiascopariaWaldst.EtKit. or Herba Artemisiae Scopariae ArtemisiacapillariesThunb. divides.Bitter, pungent, be slightly cold, return spleen, stomach, liver, gallbladder meridian.Eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice.For jaundice oliguria, hygropyrexia heat-damp in summer, eczema pruritus.
The Rhizoma Atractylodis Macrocephalae is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae AtractylodesmacrocephalaKoidz..Bitter, sweet, temperature, returns spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Semen Armeniacae Amarum is the dry mature seed of rosaceous plant Prunus armeniaca L.var.ansu Maxim. PrunusarmeniacaL.var.ansuMaxim., Siberia Fructus Pruni PrunussibiricaL., prunus mandshuricaKoehne Prunusmandshurica (Maxim.) Koehne or Fructus Pruni PrunusarmeniacaL..Bitter, tepor, slightly poisonous, return lung, large intestine channel.Sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, dryness of the intestine constipation.
The Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalusmembranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalusmembranaceus (Fisch.) Bge..Sweet, tepor.Return lung, spleen channel.Tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promotes the production of body fluid and nourishes blood, the stagnant blood stasis dispelling of row, detoxification evacuation of pus, expelling pus and promoting granulation.Weak in the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, hemiplegia, and arthralgia pain is numb, and carbuncle difficulty is burst, and bursts for a long time and does not hold back.
Radix Platycodonis is the dry root of Campanulaceae Radix Platycodonis Platycodongrandiflorum (Jacq.) A.DC..Bitter, pungent, flat.Return lung meridian.Lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia hoarseness, lung abscess vomiting pus.
Herba Pogostemonis is that the quadrate part dryly of labiate Herba Pogostemonis Pogostemoncablin (Blanco) Benth. divides.Pungent, tepor.Return spleen, stomach, lung meridian.Eliminating turbid pathogen with aromatics, and middle preventing or arresting vomiting, deliver expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is vomitted, heat-damp in summer exterior syndrome, hygropyrexia from the beginning of, heating asthenia, uncomfortable in chestly do not relax, cold-damp closes summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache.
Rhizoma Zingiberis is the dry rhizome of zingiber ZingiberofficinaleRose..Pungent, heat.Return spleen, stomach, kidney, the heart, lung meridian.Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warming the lung to resolve fluid-retention.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, cold fluid-retention is breathed with cough.
Radix Ginseng is the dry root welding technology of Araliaceae Radix Ginseng PanaxginsengC.A.Mey..Sweet, micro-hardship, tepor, return spleen, lung, the heart, kidney channel.Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid and nourish blood, Fructus Alpiniae Oxyphyllae of calming the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, deficiency of qi and blood, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb.
Pharmaceutical composition of the present invention, after reasonable compatibility, has played synergistic function, effectively can treat gastric ulcer, good analgesic effect, and has good gastric mucosal effect, for clinical application provides a kind of selection newly.
Detailed description of the invention
The preparation of embodiment 1 pharmaceutical composition of the present invention
Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Semen Phaseoli 10g, Radix Astragali 7.5g, Herba Artemisiae Scopariae 7.5g, Herba Taraxaci 7.5g, Semen Armeniacae Amarum 5g, Radix Platycodonis 5g, Herba Pogostemonis 5g, Rhizoma Zingiberis 2.5g, Radix Ginseng 2.5g; Decoct with water 3 times, first time adds 10 times amount soak by water 5 minutes, and second time adds 8 times amount soak by water 10 minutes, and third time adds 8 times amount soak by water 15 minutes, filters, and after merging decocting liquid, obtains pharmaceutical composition decoction of the present invention.
The preparation of embodiment 2 pharmaceutical composition of the present invention
Rhizoma Atractylodis Macrocephalae 180g, Poria 220g, Semen Phaseoli 220g, Radix Astragali 170g, Herba Artemisiae Scopariae 170g, Herba Taraxaci 170g, Semen Armeniacae Amarum 120g, Radix Platycodonis 120g, Herba Pogostemonis 120g, Rhizoma Zingiberis 60g, Radix Ginseng 60g; First add 4 times amount water soaking 10 minutes, then decoct with water 3 times, each 30 minutes, add water 10 times amount at every turn, filters, after merging decocting liquid, concentrated, then add proper starch, granulates, obtain medicament composition granule agent of the present invention.
The preparation of embodiment 3 pharmaceutical composition of the present invention
Rhizoma Atractylodis Macrocephalae 220g, Poria 180g, Semen Phaseoli 180g, Radix Astragali 130g, Herba Artemisiae Scopariae 130g, Herba Taraxaci 130g, Semen Armeniacae Amarum 80g, Radix Platycodonis 80g, Herba Pogostemonis 80g, Rhizoma Zingiberis 40g, Radix Ginseng 40g; First add 10 times amount 70% alcoholic solution reflux, extract, 1 time, extract 1 hour, filter, filtrate is for subsequent use, and filtering residue uses soak by water 2 times again, and add water 8 times amount at every turn, each decoction 20 minutes, after merging ethanol extract and decocting liquid, concentrated, then add appropriate microcrystalline Cellulose and dextrin and Radix Ginseng powder, after granulation, add appropriate magnesium stearate again, tabletting, obtain medicinal composition tablets of the present invention.
The preparation of embodiment 4 pharmaceutical composition of the present invention
Rhizoma Atractylodis Macrocephalae 260g, Poria 140g, Semen Phaseoli 140g, Radix Astragali 105g, Herba Artemisiae Scopariae 105g, Herba Taraxaci 105g, Semen Armeniacae Amarum 70g, Radix Platycodonis 70g, Herba Pogostemonis 70g, Rhizoma Zingiberis 35g, Radix Ginseng 35g.First add 4 times amount water soaking 10 minutes, then decoct with water 2 times, each 20 minutes, add water 10 times amount at every turn, filters, and after merging decocting liquid, obtains pharmaceutical composition decoction of the present invention.
The preparation of embodiment 5 pharmaceutical composition of the present invention
Rhizoma Atractylodis Macrocephalae 140g, Poria 260g, Semen Phaseoli 260g, Radix Astragali 195g, Herba Artemisiae Scopariae 195g, Herba Taraxaci 195g, Semen Armeniacae Amarum 130g, Radix Platycodonis 130g, Herba Pogostemonis 130g, Rhizoma Zingiberis 65g, Radix Ginseng 65g; After pulverizing, cross 80 mesh sieves, then add microcrystalline Cellulose, after mixing, encapsulated, obtain medicament composition capsule agent of the present invention.
Beneficial effect of the present invention is shown further below by way of concrete test example.
Test example 1 pharmaceutical composition of the present invention is to the treatment of gastric ulcer
Gastric Ulcer standard: upper abdomen dull pain, dull pain or burn sample pain, alleviate after taking alkalescent medicine, such pain has rhythmicity, many appearance in 1 hour after the meal, alleviated gradually after 1 ~ 2 hour, generally also there will be acid regurgitation, belch, heartburn, the indigestion symptom such as Abdeminal pain, Nausea and vomiting; The visible niche of upper digestive tract radiography; Endoscopy, can in stomach see circle or oval, bottom is smooth, the ulcer of neat in edge, ulcer surface is greyish white or brown tongue film covers, edge swelling, color and luster ruddy, smooth and soft (i.e. gastric ulcer activity time).Accept 40 examples altogether for medical treatment, endoscopy confirms as gastric ulcer.
Criterion of cure: epigastrium pain disappears, endoscopy, and visible ulcer surface white fur disappears, become red congested cicatrix, visible pleat concentrates (i.e. cicatricial phase).
Effective standard: epigastrium pain disappears or alleviates, endoscopy, and tongue film is thinning, and ulcer reduces, the blush of visible mucous epithelium regeneration around it; Or ulcer surface almost disappears, it there is few thin coating (i.e. healing stage).
Therapeutic Method: the decoction that Example 1 prepares, every bu is taken for 3 times, period in a medicine, avoids eating anything raw or cold, maror.
Criterion of cure: take medicine continuously by Therapeutic Method, treats 20 ~ 40 days, cures 35 examples, accounts for 87% of total case; Effective 5 examples, account for 13% of total case.Total effective rate reaches 100%.
The screening of test example 2 pharmaceutical composition of the present invention
Get SD rat, male and female half and half fasting is after 12 hours, rats by intraperitoneal injection 3% is anaesthetized without barbital sodium, to sterilize skin with alcohol cotton stick, cut abdominal cavity open, in glandular stomach portion, antetheca hole body intersection serosal surface sticks the circular filter paper 30s soaking into glacial acetic acid, diameter 5mm, repeat 3 times, close abdomen sewing-up cut, be coated with penicillin.Postoperative routine feeding, the 4th day by animal random packet, model group gavage 10mlkg
-1distilled water, positive drug ranitidine group gavage 30mgkg
-1, each screening group 10g crude drug/kg body weight (extracting method is with test example 1) of the present invention.The 2nd day after grouping starts gastric infusion, and administration every day 1 time, dosage is 10mlkg
-1, continuous 5 days, last administration is de-cervical vertebra execution animal after 12 hours, cut open the belly and get stomach, use brine gastric content, stomach is fixed in 10% formaldehyde, stomach is lain on glass surface ware after 15 minutes, measure major diameter and the minor axis of ulcer surface under magnifier with slide gauge, and calculate ulcer surface.
Calculate ulcer inhibition rate: ulcer inhibition rate=(matched group ulcer area-administration group ulcer area)/matched group ulcer area x100%, observe ulcer healing degree.
Experimental result is in table 1.
Table 1
Note: compared with model group, * is p<0.05, * * is p<0.01; Compared with group 4, △ is p<0.05
Wherein, the compatibility of each screening group is as follows:
Group 1: Rhizoma Atractylodis Macrocephalae 15g, Poria 15g, Semen Phaseoli 7g, Radix Astragali 5g, Herba Artemisiae Scopariae 5g, Herba Taraxaci 15g, Semen Armeniacae Amarum 8g, Radix Platycodonis 8g, Herba Pogostemonis 7g, Rhizoma Zingiberis 1g, Radix Ginseng 4g;
Group 2: Rhizoma Atractylodis Macrocephalae 12g, Poria 12g, Semen Phaseoli 12g, Radix Astragali 7.5g, Herba Artemisiae Scopariae 7.5g, Herba Taraxaci 10g, Semen Armeniacae Amarum 3g, Radix Platycodonis 3g, Herba Pogostemonis 10g, Rhizoma Zingiberis 4g, Radix Ginseng 5g;
Group 3: Rhizoma Atractylodis Macrocephalae 7g, Poria 7g, Semen Phaseoli 10g, Radix Astragali 9g, Herba Artemisiae Scopariae 10g, Herba Taraxaci 10g, Semen Armeniacae Amarum 5g, Radix Platycodonis 6g, Herba Pogostemonis 5g, Rhizoma Zingiberis 2.5g, Radix Ginseng 2.5g;
Group 4: Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Semen Phaseoli 10g, Radix Astragali 7.5g, Herba Artemisiae Scopariae 7.5g, Herba Taraxaci 7.5g, Semen Armeniacae Amarum 5g, Radix Platycodonis 5g, Herba Pogostemonis 5g, Rhizoma Zingiberis 2.5g, Radix Ginseng 2.5g.
Above-mentioned each group of compound recipe, flavour of a drug are identical, but medical material consumption proportion difference has appreciable impact to the drug activity of compound recipe: group 1-3, all has certain inhibitory action (p<0.05) to the gastric ulcer of animal pattern; But the prescription proportioning of employing group 4, can significantly improve the therapeutic activity of compound medicine, and its activity is significantly better than other each proportioning groups (p<0.05), and therefore, the present invention preferably organizes the prescription proportioning of 4.Above-mentioned test shows, pharmaceutical composition of the present invention, under specific proportioning, has played synergistic function.
Test example 3 pharmaceutical composition of the present invention is to the therapeutical effect of acetic acid type gastric ulcer
Get SD rat, fasting is after 12 hours, and rats by intraperitoneal injection 3% is anaesthetized without barbital sodium, to sterilize skin with alcohol cotton stick, cut abdominal cavity open, in glandular stomach portion, antetheca hole body intersection serosal surface sticks the circular filter paper 30s soaking into glacial acetic acid, diameter 5mm, repeat 3 times, close abdomen sewing-up cut, be coated with penicillin.Postoperative routine feeding, is divided into 6 groups at random by animal on the 4th day, and often organize 10, male and female half and half, are respectively model group (10mlkg
-1distilled water), pharmaceutical composition senior middle school of the present invention low dose group (be followed successively by 10,20,40g crude drug/kg body weight), contrast groups 1 (20g crude drug/kg body weight), contrast groups 2 (20g crude drug/kg body weight), positive drug ranitidine group (30mgkg
-1).The 2nd day after grouping starts gastric infusion, and administration every day 1 time, dosage is 10mlkg
-1, continuous 5 days, last administration is de-cervical vertebra execution animal after 12 hours, cut open the belly and get stomach, use brine gastric content, stomach is fixed in 10% formaldehyde, stomach is lain on glass surface ware after 15 minutes, measure major diameter and the minor axis of ulcer surface under magnifier with slide gauge, and calculate ulcer surface.
Calculate ulcer inhibition rate: ulcer inhibition rate=(matched group ulcer area-administration group ulcer area)/matched group ulcer area x100%, observe ulcer healing degree.
Pharmaceutical composition of the present invention is prepared by embodiment 1;
The preparation method of contrast groups 1 medicine is as follows:
Get Fructus Amomi Rotundus 10g, Rhizoma Atractylodis Macrocephalae 20g, Poria 20g, Herba Pogostemonis 15g, Herba Taraxaci 15g, Radix Ginseng 5g, Folium Perillae 10g, Semen Armeniacae Amarum 10g, Semen Coicis 20g, Herba Artemisiae Scopariae 15g; Decoct with water 3 times, first time adds 10 times amount soak by water 5 minutes, and second time adds 8 times amount soak by water 10 minutes, and third time adds 8 times amount soak by water 15 minutes, filters, and after merging decocting liquid, obtains contrast groups 1 decoction.
The preparation method of contrast groups 2 medicine is as follows:
Semen Coicis 20 parts, Semen Benincasae 20 parts, Herba Artemisiae Scopariae 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Folium Perillae 10 parts, Semen Armeniacae Amarum 10 parts, Semen Lablab Album 10 parts, Semen Myristicae 10 parts, the Radix Astragali 10 parts, Radix Ginseng 5 parts, Fructus Forsythiae 5 parts.First add 4 times amount water soaking 10 minutes, then decoct with water 2 times, each 20 minutes, add water 10 times amount at every turn, filters, and after merging decocting liquid, obtains contrast groups 2 decoction.
Experimental result is in table 2.
Table 2
Note: compared with model group, * is p<0.05, * * is p<0.01; Compared with low dose group of the present invention, △ is p<0.05.
As shown in Table 2:
(1) pharmaceutical composition of the present invention, effectively can treat gastric ulcer, simultaneously, compared with contrast groups 1, although medicine composition is similar, but pharmaceutical composition of the present invention is all obviously being better than contrast groups 1 (p<0.05) compared with the drug activity under low dosage or Isodose;
(2) compared with contrast groups 2, the present invention is low dosage (10gKg comparatively
-1) time ulcer inhibitory action just suitable with contrast groups 2, during Isodose, drug activity of the present invention is more notable is better than contrast groups 2.
Above-mentioned experiment shows, pharmaceutical composition of the present invention, after the rational concerted application of drugs of screening, has played synergistic function.
In sum, pharmaceutical composition of the present invention is after reasonable compatibility, and pharmaceutical composition of the present invention has played synergistic function, effectively can treat gastric ulcer, for clinical application provides a kind of new selection.
Claims (3)
1. the purposes of following pharmaceutical composition in the medicine of preparation treatment gastric ulcer; This pharmaceutical composition be the preparation be prepared from by the crude drug of following weight proportion:
Rhizoma Atractylodis Macrocephalae 14-26 part, Poria 14-26 part, Semen Phaseoli 14-26 part, Radix Astragali 10.5-19.5 part, Herba Artemisiae Scopariae 10.5-19.5 part, Herba Taraxaci 10.5-19.5 part, Semen Armeniacae Amarum 7-13 part, Radix Platycodonis 7-13 part, Herba Pogostemonis 7-13 part, Rhizoma Zingiberis 3.5-6.5 part, Radix Ginseng 3.5-6.5 part.
2. pharmaceutical composition according to claim 1, is characterized in that: this pharmaceutical composition is the preparation be prepared from by the crude drug of following weight proportion:
Rhizoma Atractylodis Macrocephalae 9-11 part, Poria 9-11 part, Semen Phaseoli 9-11 part, Radix Astragali 7-8 part, Herba Artemisiae Scopariae 7-8 part, Herba Taraxaci 7-8 part, Semen Armeniacae Amarum 4-6 part, Radix Platycodonis 4-6 part, Herba Pogostemonis 4-6 part, Rhizoma Zingiberis 2-3 part, Radix Ginseng 2-3 part.
3. pharmaceutical composition according to claim 2, is characterized in that: this pharmaceutical composition is the preparation be prepared from by the crude drug of following weight proportion:
The Rhizoma Atractylodis Macrocephalae 10 parts, 10 parts, Poria, Semen Phaseoli 10 parts, the Radix Astragali 7.5 parts, Herba Artemisiae Scopariae 7.5 parts, Herba Taraxaci 7.5 parts, Semen Armeniacae Amarum 5 parts, Radix Platycodonis 5 parts, Herba Pogostemonis 5 parts, Rhizoma Zingiberis 2.5 parts, Radix Ginseng 2.5 parts.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006182679A (en) * | 2004-12-27 | 2006-07-13 | Daicho Kikaku:Kk | Preventing and treating agent of stress gastritis |
| CN102416121A (en) * | 2011-12-10 | 2012-04-18 | 成都酷妃儿商贸有限公司 | Application of medicinal composition to preparation of medicaments for treating gastric ulcer |
| CN103272169A (en) * | 2013-06-26 | 2013-09-04 | 中国科学院西北高原生物研究所 | Application of rhodiola rosea compound composite in treating erosive gastritis |
| CN103285310A (en) * | 2013-06-26 | 2013-09-11 | 中国科学院西北高原生物研究所 | Use of rhodiola rosea compound composition in preparing medicine for curing gastric ulcer |
| CN104689265A (en) * | 2013-12-04 | 2015-06-10 | 王晓娟 | Chinese herbal medicine prescription for treating gastric ulcer |
-
2015
- 2015-09-30 CN CN201510638771.8A patent/CN105214030A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006182679A (en) * | 2004-12-27 | 2006-07-13 | Daicho Kikaku:Kk | Preventing and treating agent of stress gastritis |
| CN102416121A (en) * | 2011-12-10 | 2012-04-18 | 成都酷妃儿商贸有限公司 | Application of medicinal composition to preparation of medicaments for treating gastric ulcer |
| CN103272169A (en) * | 2013-06-26 | 2013-09-04 | 中国科学院西北高原生物研究所 | Application of rhodiola rosea compound composite in treating erosive gastritis |
| CN103285310A (en) * | 2013-06-26 | 2013-09-11 | 中国科学院西北高原生物研究所 | Use of rhodiola rosea compound composition in preparing medicine for curing gastric ulcer |
| CN104689265A (en) * | 2013-12-04 | 2015-06-10 | 王晓娟 | Chinese herbal medicine prescription for treating gastric ulcer |
Non-Patent Citations (1)
| Title |
|---|
| "《现代中药基础研究与临床》" * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106237224A (en) * | 2016-08-27 | 2016-12-21 | 朱保群 | A kind of Chinese medicine composition treating gastropathy and preparation method thereof |
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