CN103285310A - Use of rhodiola rosea compound composition in preparing medicine for curing gastric ulcer - Google Patents
Use of rhodiola rosea compound composition in preparing medicine for curing gastric ulcer Download PDFInfo
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- CN103285310A CN103285310A CN2013102609626A CN201310260962A CN103285310A CN 103285310 A CN103285310 A CN 103285310A CN 2013102609626 A CN2013102609626 A CN 2013102609626A CN 201310260962 A CN201310260962 A CN 201310260962A CN 103285310 A CN103285310 A CN 103285310A
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Abstract
The invention provides use of a rhodiola rosea compound composition in preparing a medicine for curing gastric ulcer. The medicine disclosed by the invention is a preparation prepared from the following bulk drugs in weight ratio: 4.2-7.2 parts of rhodiola rosea, 14-26 parts of poria cocos, 10.5-19.5 parts of dandelion, 10.5-19.5 parts of oriental wormwood, 10.5-19.5 parts of bighead atractylodes rhizome, 7-13 parts of pogostemon cablin, 7-13 parts of raw malt and 3.5-6.5 parts of cardamun. The rhodiola rosea compound composition disclosed by the invention is precise and appropriate in drug compatibility and has little medicine flavour, therefore, the medicine effect is ensured; the side effects are reduced; gastric ulcer can be effectively treated; a new choice is provided for clinical treatment.
Description
Technical field
The present invention relates to the purposes of a kind of Radix Rhodiolae compound in the medicine of preparation treatment gastric ulcer.
Background technology
Stomach, duodenal ulcer refer to that the limitation of stomach, duodenum mucosa is circular or oval holostrome is damaged, and muscularis mucosae is penetrated, and leaves fibrous scar after the healing inevitably, and the surface is covered by one deck epithelium, and muscularis mucosae can not be regenerated.It is owing to multiple reason causes that gastric acid, pepsin are destroyed to self-digestion or the gastric mucosal barrier of gastric mucosa that its cause of disease is summarized.Think that in recent years formation and the gastric Helicobacter pylori infection of ulcer also have important relationship.
Chronic erosive gastritis claims indigestion symptoms such as general rarely seen glutted, the pantothenic acid after meal of gastritis verrucosa or varioliform gastritis, belch, irregularities stomachache again.A plurality of excipuliforms appear in patient's gastric mucosa, expand folded shape or pimple sample protuberance, diameter 5～10mm, and the visible mucomembranous defect in top or umbilicus sample depression, there is erosion at the center, many no blush around the protuberance, but often with the similar erythema of size, portion sees more with gastric antrum.
The medicine of the above-mentioned disease of current treatment mostly is chemical medicine, and it is expensive, and side effect is big, and the healing required time is long.Therefore, be badly in need of a kind of economical and practical, toxic and side effects is low, and can rapid healing the medicine of above-mentioned disease.
And Chinese medicine aspect treatment of chronic diseases one to all playing an important role.Report that with Concha Arcae 75% and Radix Glycyrrhizae 25%, red in pulv, treatment gastric and duodenal ulcers, cure rate reaches 76% (" Chinese medicine voluminous dictionary " second edition, Shanghai science tech publishing house, in March, 2006, the 548th～549 page); Human Os Sepiae (life) 250g, Concha Arcae (calcined) 250g are also arranged, Radix Et Rhizoma Rhei 200g, Radix Glycyrrhizae Preparata 200g grinds to the powder, boiled water is taken after mixing it with water after meal, and each 15g, is used for the treatment of peptic ulcer (Gu Linjiang at every day 3～4 times, Os Sepiae looses and treats peptic ulcer, journal of shanghai Chinese medicine, 9 phases of calendar year 2001.Also there are human Fructus Amomi Rotundus 10g, Rhizoma Atractylodis Macrocephalae 20g, Poria 20g, Herba Pogostemonis 15g, Herba Taraxaci 15g, Radix Ginseng 5g, Folium Perillae 10g, Semen Armeniacae Amarum 10g, Semen Coicis 20g, Herba Artemisiae Scopariae 15g to treat peptic ulcer, have better therapeutic effect.
Summary of the invention
The object of the present invention is to provide the purposes of a kind of Radix Rhodiolae compound in the medicine of preparation treatment gastric ulcer.
The invention provides the purposes of following Radix Rhodiolae compound in the medicine of preparation treatment gastric ulcer; This medicine be the preparation that is prepared from by following materials of weight proportions medicine:
Radix Rhodiolae 4.2-7.2 part, Poria 14-26 part, Herba Taraxaci 10.5-19.5 part, Herba Artemisiae Scopariae 10.5-19.5 part, Rhizoma Atractylodis Macrocephalae 10.5-19.5 part, Herba Pogostemonis 7-13 part, Fructus Hordei Germinatus 7-13 part, Fructus Amomi Rotundus 3.5-6.5 part.
Further, this medicine is the preparation that is prepared from by following materials of weight proportions medicine:
Radix Rhodiolae 5-7 part, Poria 18-22 part, Herba Taraxaci 13-17 part, Herba Artemisiae Scopariae 13-17 part, Rhizoma Atractylodis Macrocephalae 13-17 part, Herba Pogostemonis 8-12 part, Fructus Hordei Germinatus 8-12 part, Fructus Amomi Rotundus 4-6 part.
Further preferably, this medicine is the preparation that is prepared from by following materials of weight proportions medicine:
6 parts of Radix Rhodiolaes, 20 parts in Poria, 15 parts of Herba Taraxacis, 15 parts of Herba Artemisiae Scopariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Herba Pogostemonis, 10 parts of Fructus Hordei Germinatus, 5 parts in Fructus Amomi Rotundus.
Wherein, described Fructus Amomi Rotundus is Fructus Amomi Rotundus.
Wherein, described preparation is oral formulations.
Further, described oral formulations is pill, capsule, powder, granule, tablet, drop pill, soft capsule or oral liquid.
Among the present invention, Radix Rhodiolae is dry root and the rhizome of Crassulaceae plant Radix Rhodiolae Rhodiola crenulata (Hool.f.et Thoms.) H.Ohba.Sweet, bitter, flat, return lung, heart channel, benefiting QI for activating blood circulation is promoted blood circulation and is relievingd asthma.Be used for blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia asthma.
Herba Artemisiae Scopariae is the branch of quadrate part dryly of feverfew BINHAO Artemisia scoparia Waldst.Et Kit. or Herba Artemisiae Scopariae Artemisia capillaries Thunb..Bitter, hot, be slightly cold, return spleen, stomach, liver, gallbladder meridian.Eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice.Be used for the jaundice oliguria, hygropyrexia heat-damp in summer, eczema pruritus.
The Rhizoma Atractylodis Macrocephalae is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Bitter, sweet, temperature is returned spleen, stomach warp.Invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Poria is the dry sclerotia of Polyporaceae fungus Poria Poria cocos (Schw.) Wolf.Sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.
Herba Taraxaci is Herba Taraxaci Taraxacum mongolicum Hand.Mazz, alkali ground Herba Taraxaci Taraxacum borealisinense Kitam. or the dry herb that belongs to several plants together.Bitter, sweet, cold.Return liver, stomach warp.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.Be used for furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Herba Pogostemonis is the branch of quadrate part dryly of labiate Herba Pogostemonis Pogostemon cablin (Blanco) Benth..Suffering, tepor.Return spleen, stomach, lung meridian.Eliminating turbid pathogen with aromatics and middle preventing or arresting vomiting are delivered expelling summer-heat.Be used for turbid damp obstructing in middle-JIAO, the vomiting of gastral cavity painful abdominal mass, heat-damp in summer exterior syndrome, hygropyrexia be from the beginning of, heating asthenia, uncomfortable in chestly do not relax, and cold-damp is closed summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache.
Compatibility of drugs of the present invention is precise and appropriate, and flavour of a drug are less, has not only guaranteed drug effect to have reduced side effect, can effectively treat gastric ulcer, for clinical application provides a kind of new selection.
The specific embodiment
The preparation of embodiment 1 medicine of the present invention
Get Poria 20g, Herba Taraxaci 15g, Herba Artemisiae Scopariae 15g, Rhizoma Atractylodis Macrocephalae 15g, Herba Pogostemonis 10g, Fructus Hordei Germinatus 10g, Radix Rhodiolae 6g, Fructus Amomi Rotundus 5g; Add 4 times of water gagings earlier and soaked 10 minutes, decoct with water again 2 times, each 20 minutes, add 10 times of amounts of water at every turn, filter, behind the merging decocting liquid, get medicine decoction of the present invention.
The preparation of embodiment 2 medicines of the present invention
Poria 20g, Herba Taraxaci 15g, Herba Artemisiae Scopariae 15g, Rhizoma Atractylodis Macrocephalae 15g, Herba Pogostemonis 10g, Fructus Hordei Germinatus 10g, Radix Rhodiolae 6g, Fructus Amomi Rotundus 5g; Decoct with water 3 times, add 10 times of water gagings decoctions 5 minutes for the first time, add 8 times of water gagings for the second time and decocted 10 minutes, add 8 times of water gagings for the third time and decocted 15 minutes, filter, behind the merging decocting liquid, concentrate, add proper starch again, granulate, get medicinal granule of the present invention.
The preparation of embodiment 3 medicines of the present invention
Get Poria 20g, Herba Taraxaci 15g, Herba Artemisiae Scopariae 15g, Rhizoma Atractylodis Macrocephalae 15g, Herba Pogostemonis 10g, Fructus Hordei Germinatus 10g, Radix Rhodiolae 6g, Fructus Amomi Rotundus 5g; Add 10 times of amount 70% alcoholic solution reflux, extract, earlier 1 time, extracted 1 hour, filter, filtrate for later use, filtering residue reuse decocting boils 2 times, adds 8 times of amounts of water at every turn, the each decoction 20 minutes, after merging ethanol extract and decocting liquid, concentrate, add an amount of microcrystalline Cellulose and dextrin and Radix Rhodiolae powder again, after the granulation, add an amount of magnesium stearate again, tabletting namely gets medicinal tablet of the present invention.
The preparation of embodiment 4 medicines of the present invention
Get Poria 18g, Herba Taraxaci 17g, Herba Artemisiae Scopariae 17g, Rhizoma Atractylodis Macrocephalae 17g, Herba Pogostemonis 12g, Fructus Hordei Germinatus 12g, Radix Rhodiolae 7g, Fructus Amomi Rotundus 6g; Add 4 times of water gagings earlier and soaked 10 minutes, decoct with water again 2 times, each 20 minutes, add 10 times of amounts of water at every turn, filter, behind the merging decocting liquid, get medicine decoction of the present invention.
The preparation of embodiment 5 medicines of the present invention
Get Poria 22g, Herba Taraxaci 13g, Herba Artemisiae Scopariae 13g, Rhizoma Atractylodis Macrocephalae 13g, Herba Pogostemonis 8g, Fructus Hordei Germinatus 8g, Radix Rhodiolae 5g, Fructus Amomi Rotundus 4g; After the pulverizing, cross 80 mesh sieves, add microcrystalline Cellulose again, encapsulated behind the mixing, namely get medicine capsule of the present invention.
Below further show beneficial effect of the present invention by concrete test example.
Test example 1 medicine of the present invention is to the treatment of gastric ulcer
Gastric ulcer diagnostic criteria: upper abdomen dull pain, dull pain or burn sample pain, alleviate after taking alkalescent medicine, such pain has rhythmicity, how in 1 hour after the meal, to occur, after 1～2 hour, alleviate gradually, acid regurgitation, belch, heartburn, indigestion symptoms such as upper abdomen is glutted, nauseating, vomiting generally also can occur; The visible niche of upper digestive tract radiography; Endoscopy, can in stomach see circle or oval, the bottom is smooth, the ulcer of neat in edge, ulcer surface is greyish white or brown tongue film covers edge swelling, color and luster ruddy, smooth and soft (being the gastric ulcer active stage).Accept 30 examples altogether for medical treatment, endoscopy is confirmed as gastric ulcer.
Criterion of cure: epigastrium pain disappears, endoscopy, and visible ulcer surface white fur disappears, becomes red congested cicatrix, and visible pleat is concentrated (being cicatricial phase).
Effective standard: epigastrium pain disappears or alleviates, endoscopy, and the attenuation of tongue film, ulcer is dwindled, the blush that visible mucous epithelium is regenerated around it; Or ulcer surface almost disappears, and few thin coating (being healing stage) is arranged on it.
Therapeutic Method: get the decoction that embodiment 1 prepares, divide every day and take for 3 times, period in a medicine is avoided eating anything raw or cold, maror.
Criterion of cure: take medicine continuously by Therapeutic Method, treated 20～30 days, cure 30 examples, account for 100% of total case.
Model case 1
Xu certain, the man, 30 years old, stomach felt that feeling of repletion is arranged, abdominal pain sensuously about 1 hour after the meal, pain disappears when having a meal, after meal or close on ante cibum the belch phenomenon is arranged, body weight obviously alleviates; History of drinking history is arranged, through endoscopy, confirm as gastric ulcer.
After taking medicine 7 days by test example 1 method, feeling of repletion, belch, pain phenomenon are alleviated, and after 15 days, it is suitable with normal period that appetite has recovered, bloated sense, belch, pain phenomenon disappear, after 30 days, through gastroscopy, ulcer surface heals substantially, and conscious appetite, stomach feel good, and body weight is gone up.
Test example 2 pharmaceutical compositions of the present invention are to the therapeutical effect of acetic acid type gastric ulcer
Get the SD rat, fasting is after 12 hours, and rats by intraperitoneal injection 3% no barbital sodium is anaesthetized, with the alcohol cotton stick skin of sterilizing, cut the abdominal cavity open, antetheca hole body intersection serosal surface sticks the circular filter paper 30s that soaks into glacial acetic acid, diameter 5mm in glandular stomach portion, repeat 3 times, close abdomen and sew up wound, be coated with penicillin.The postoperative routine feeding was divided into 6 groups at random with animal on the 4th day, and 10 every group, male and female half and half are respectively model group (10mlkg
-1Distilled water), pharmaceutical composition of the present invention senior middle school low dose group (be followed successively by 20,40,80g crude drug/kg body weight), contrast groups A (20g crude drug/kg body weight), contrast groups B (20g crude drug/kg body weight), positive drug ranitidine group (30mgkg
-1).In grouping back beginning in the 2nd day gastric infusion, administration every day 1 time, dosage is 10mlkg
-1, continuous 5 days, the last administration was taken off cervical vertebra and is put to death animal after 12 hours, cut open the belly and get stomach, wash gastric content with normal saline, stomach is fixed in 10% formaldehyde, after 15 minutes stomach is lain on the glass surface ware, measure major diameter and the minor axis of ulcer surface under the magnifier with slide gauge, and calculate ulcer surface.
Calculate ulcer inhibition rate: ulcer inhibition rate=(matched group ulcer area-administration group ulcer area)/matched group ulcer area x100%, observe the ulcer healing degree.
Pharmaceutical composition of the present invention is by embodiment 1 preparation;
The preparation method of contrast groups A medicine is as follows:
Get Fructus Amomi Rotundus 10g, Rhizoma Atractylodis Macrocephalae 20g, Poria 20g, Herba Pogostemonis 15g, Herba Taraxaci 15g, Radix Ginseng 5g, Folium Perillae 10g, Semen Armeniacae Amarum 10g, Semen Coicis 20g, Herba Artemisiae Scopariae 15g; Add 4 times of water gagings earlier and soaked 10 minutes, decoct with water again 2 times, each 20 minutes, add 10 times of amounts of water at every turn, filter, behind the merging decocting liquid, get contrast groups A decoction.
The preparation method of contrast groups B medicine is as follows:
20 parts of Semen Coiciss, 20 parts of Semen Benincasaes, 15 parts of Herba Artemisiae Scopariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Folium Perillaes, 10 parts of Semen Armeniacae Amarums, 10 parts of Semen Lablab Albums, 10 parts of Semen Myristicaes, 10 parts of the Radixs Astragali, 5 parts of Radix Ginsengs, 5 parts of Fructus Forsythiaes.Add 4 times of water gagings earlier and soaked 10 minutes, decoct with water again 2 times, each 20 minutes, add 10 times of amounts of water at every turn, filter, behind the merging decocting liquid, get contrast groups B decoction.
Experimental result sees Table 1.
Table 1
Annotate: compare with model group, * is p＜0.05, and * * is p＜0.01; A compares with contrast groups, and △ is p＜0.05; B compares with contrast groups, and a is p＜0.05.
As shown in Table 1, pharmaceutical composition of the present invention can effectively be treated gastric ulcer, and simultaneously, A compares with contrast groups, though the medicine composition is similar, and, the drug activity of pharmaceutical composition of the present invention under Isodose obviously is better than contrast groups A (p＜0.05).B compares with contrast groups, and the drug activity under the Isodose is suitable, but present composition flavour of a drug still less.Above-mentioned test shows that pharmaceutical composition compatibility of the present invention is precise and appropriate, has brought into play synergistic function.
Test example 3 contrasts with the clinical drug effect of contrast groups B
Except above-mentioned case, the case of also having accepted gastric ulcer for medical treatment is totally 11 people, all uses following prescription to treat: 20 parts of Semen Coiciss, 20 parts of Semen Benincasaes, 15 parts of Herba Artemisiae Scopariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Folium Perillaes, 10 parts of Semen Armeniacae Amarums, 10 parts of Semen Lablab Albums, 10 parts of Semen Myristicaes, 10 parts of the Radixs Astragali, 5 parts of Radix Ginsengs, 5 parts of Fructus Forsythiaes.
Treat after 10 days, the patient more than 90% thinks that epigastric discomfort slows down or disappears, and appetite improves, and shows that its peptic ulcer has taken a favorable turn or healing trend, but most of patients is after medication, flatulence in the lower abdomen, and empty respectful number of times obviously increases.
And adopt medicine of the present invention to treat, side effect such as flatulence in the lower abdomen do not appear in patient, and the cure rate height, show that the present invention behind the flavour of a drug composition that changes prescription and medical material consumption, has not only guaranteed curative effect, have also reduced side effect.
In sum, compatibility of drugs of the present invention is precise and appropriate, and flavour of a drug are less, has not only guaranteed drug effect to have reduced side effect, can effectively treat gastric ulcer, for clinical application provides a kind of new selection.
Claims (6)
1. the purposes of following Radix Rhodiolae compound in the medicine of preparation treatment gastric ulcer; This medicine be the preparation that is prepared from by following materials of weight proportions medicine:
Radix Rhodiolae 4.2-7.2 part, Poria 14-26 part, Herba Taraxaci 10.5-19.5 part, Herba Artemisiae Scopariae 10.5-19.5 part, Rhizoma Atractylodis Macrocephalae 10.5-19.5 part, Herba Pogostemonis 7-13 part, Fructus Hordei Germinatus 7-13 part, Fructus Amomi Rotundus 3.5-6.5 part.
2. medicine according to claim 1, it is characterized in that: this medicine is the preparation that is prepared from by following materials of weight proportions medicine:
Radix Rhodiolae 5-7 part, Poria 18-22 part, Herba Taraxaci 13-17 part, Herba Artemisiae Scopariae 13-17 part, Rhizoma Atractylodis Macrocephalae 13-17 part, Herba Pogostemonis 8-12 part, Fructus Hordei Germinatus 8-12 part, Fructus Amomi Rotundus 4-6 part.
3. medicine according to claim 2, it is characterized in that: this medicine is the preparation that is prepared from by following materials of weight proportions medicine:
6 parts of Radix Rhodiolaes, 20 parts in Poria, 15 parts of Herba Taraxacis, 15 parts of Herba Artemisiae Scopariaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Herba Pogostemonis, 10 parts of Fructus Hordei Germinatus, 5 parts in Fructus Amomi Rotundus.
4. according to the described medicine of claim 1-3, it is characterized in that: described Fructus Amomi Rotundus is Fructus Amomi Rotundus.
5. according to the described medicine of claim 1-4, it is characterized in that: described preparation is oral formulations.
6. medicine according to claim 5, it is characterized in that: described oral formulations is pill, capsule, powder, granule, tablet, drop pill, soft capsule or oral liquid.
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Cited By (9)
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| CN105214030A (en) * | 2015-09-30 | 2016-01-06 | 成都恒凌科技有限公司 | The purposes of a kind of pharmaceutical composition in the medicine of preparation treatment gastric ulcer |
| CN105214034A (en) * | 2015-09-30 | 2016-01-06 | 成都恒凌科技有限公司 | The powder for the treatment of peptic ulcer |
| CN105233201A (en) * | 2015-09-30 | 2016-01-13 | 成都恒凌科技有限公司 | Solid dispersible granules for treating peptic ulcers |
| CN105233199A (en) * | 2015-09-30 | 2016-01-13 | 成都恒凌科技有限公司 | Micro-powder granules for treating digestive ulcer |
| CN105250943A (en) * | 2015-09-30 | 2016-01-20 | 成都恒凌科技有限公司 | Aqueous extract capsules for treating peptic ulcers |
| CN105250945A (en) * | 2015-09-30 | 2016-01-20 | 成都恒凌科技有限公司 | Aqueous extract tablets for treating peptic ulcers |
| CN105250944A (en) * | 2015-09-30 | 2016-01-20 | 成都恒凌科技有限公司 | Capsules for treating peptic ulcers |
| CN105250946A (en) * | 2015-09-30 | 2016-01-20 | 成都恒凌科技有限公司 | Solid dispersion for treating peptic ulcers |
| EP2992890A4 (en) * | 2013-04-24 | 2017-02-08 | University-Industry Cooperation Group of Kyung Hee University | Pharmaceutical composition |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2992890A4 (en) * | 2013-04-24 | 2017-02-08 | University-Industry Cooperation Group of Kyung Hee University | Pharmaceutical composition |
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| CN105233201A (en) * | 2015-09-30 | 2016-01-13 | 成都恒凌科技有限公司 | Solid dispersible granules for treating peptic ulcers |
| CN105233199A (en) * | 2015-09-30 | 2016-01-13 | 成都恒凌科技有限公司 | Micro-powder granules for treating digestive ulcer |
| CN105250943A (en) * | 2015-09-30 | 2016-01-20 | 成都恒凌科技有限公司 | Aqueous extract capsules for treating peptic ulcers |
| CN105250945A (en) * | 2015-09-30 | 2016-01-20 | 成都恒凌科技有限公司 | Aqueous extract tablets for treating peptic ulcers |
| CN105250944A (en) * | 2015-09-30 | 2016-01-20 | 成都恒凌科技有限公司 | Capsules for treating peptic ulcers |
| CN105250946A (en) * | 2015-09-30 | 2016-01-20 | 成都恒凌科技有限公司 | Solid dispersion for treating peptic ulcers |
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| CN103285310B (en) | 2014-12-17 |
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