CN1025774C - Special "shanhaidan" and its production method - Google Patents
Special "shanhaidan" and its production method Download PDFInfo
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- CN1025774C CN1025774C CN 93100199 CN93100199A CN1025774C CN 1025774 C CN1025774 C CN 1025774C CN 93100199 CN93100199 CN 93100199 CN 93100199 A CN93100199 A CN 93100199A CN 1025774 C CN1025774 C CN 1025774C
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Abstract
The present invention discloses a medicine for curing the coronary disease. A formula of the medicine is composed of goat blood, Chinese caterpillar fungus, bear gall, saffron, deer heart blood, milkvetch root, fleeceflower root, rosewood heart wood, seaweed, notoginseng, Rhizoma Corydalis, toad venom, red sage root, lucid ganoderma, szechwan lovage rhizome, musk, American ginseng, amber, fritillariae tuber and borneol. The medicine can be made into capsules or tablets.
Description
The present invention relates to a kind of medicine and production method thereof for the treatment of coronary heart disease, this medicine is raw material with Chinese medicine, through processed, is prepared into a kind of good effect, the Chinese patent medicine of taking convenience.
The invention belongs to field of traditional Chinese, specifically, belong to the medicine production method for the treatment of coronary heart disease.Obtained remarkable progress for the drug research of treatment cardiovascular and cerebrovascular disease both at home and abroad in recent years.For example, successively being used for clinical Chinese medicine and western medicine has: trinitin sheet, persantin, FUFANG DANSHEN PIAN, storax pill for treating coronary heart disease, SUXIAO JIUXIN WAN, heart and brain relax etc.Though these medicines all have certain curative effect for coronary heart disease,, on effecting a permanent cure, all not ideal enough from late result.At this kind situation, I draw teacher's experience on the basis of secret prescription handed down in the family from generation to generation, sum up the cognition of oneself, and the QI and blood theory of preventing and treating cardiovascular and cerebrovascular disease with the traditional Chinese medical science is a guiding theory, has been developed into special " Shanhaidan " capsule and tablet.
Therefore, the object of the invention is exactly in order to overcome above-mentioned all defectives of the prior art, for patients with coronary heart disease provides a kind of remarkably productive, late result medicine preferably.
Another object of the present invention is that it had both paid attention to taking stopgap measures for patients with coronary heart disease provides a kind of novel medicine, pays attention to again effecting a permanent cure, and has both paid attention to treatment, pays attention to prevention again, reaches and adjusts the whole body QI and blood, acts on the partial purpose of heart again.
The present invention realizes like this.
The composition of raw materials of medicine of the present invention is formed: (consumption is meant the crude drug weight ratio in the prescription)
Rhizoma Chuanxiong 8-25 Radix Salviae Miltiorrhizae 10-30 Radix Astragali 10-30 Sargassum 8-25
Ganoderma 5-20 Moschus 0.1-0.5 Radix Polygoni Multiflori 8-25 Sanguis Naemorhedi 8-15
Dear heart blood 1-5 Radix Panacis Quinquefolii 2-5 Cordyceps 1-5 Radix Notoginseng 1-5
Succinum 1-5 Fel Ursi 1-5 corydalis tuber 8-15 Bulbus Fritillariae Uninbracteatae 5-10
Stigma Croci 1-5 Lignum Dalbergiae Odoriferae 4-10 Venenum Bufonis 0.1-0.5 Borneolum Syntheticum 0.1-0.5
The consumption of each component has been represented the proportionate relationship between them in the above-mentioned prescription, in the middle of actual production, can enlarge at double arbitrarily according to the weight proportion relation of this prescription or dwindle.This change all belongs within the scope of the present invention.
The principle that medicine processing technology of the present invention is followed is:
(1) as much as possible the extracting of native chemical composition that all medicines is contained.In the leaching process, respect the principle of Chinese medicine tradition processing procedure, press close to traditional handicraft as far as possible, and, reduce the loss of its native chemical composition as far as possible with reference to the foundation that provides in the achievements such as the chemistry in the modern Chinese medicine research, pharmacology, clinical pathology.
(2), Chinese medicine compound is not simple " adduction " of single medicinal material, is the compatibility effect by the complexity between all medicines, makes it to form new composition, produces the change of matter.The principle of following in the drug action that the messenger drug deposits yields is comprehensive, Here it is this compound preparation process is to guarantee its clinical efficacy.Thereby taked following concrete measure:
1, is the preparation principle of host type with traditional compound decoction, cooperates other modern science and technology and method.All medical herbs flood with containing the abundant Maifanitum water of trace element earlier among the we, and reflux, extract.
2, basis result of study in recent years, some Chinese herbal medicine such as Radix Salviae Miltiorrhizae etc., the chemical analysis that water proposes has distinct physiologically active with the chemical analysis that proposes with ethanol.So in this process, after all liquid medicine extracts, reuse hexanol reflux, extract.In the hope of proposing more comprehensive native chemical composition.
3, the contained chemical analysis of Chinese herbal medicine is all very complicated, and result of study shows, what of chemical analysis kind that proposes in the Different concentrations of alcohol and amount all are not quite similar.So this technology be adopt repeatedly, ethanol that gradient concentration is different, reflux, extract.
4, studies show that of trace element in the Chinese medicine, what of the kind of contained trace element, quantity have confidential relation with clinical efficacy.This process is made extracting solution with Maifanitum water, to improve micronutrient levels.
5, take suitable technical measures: (1) reflux, extract,, (2) are reclaimed solvent and are adopted fractionating device, and normal pressure reclaims, and reduces the loss of volatile component as far as possible.
6, grouping is extracted: plant amedica is many, and animal drugs and certain tittle are few with water and alcohol extraction, and medicine that volatile component is more such as Borneolum Syntheticum etc. directly are used as medicine.
7, mix at last in all medicine processes, take to heat 80-90 ℃ of mixing, decocting in water composition alternating action is abundant, near the water decoction traditional handicraft, brings into play " comprehensive function " of all medicine compatibilities.
Below in conjunction with embodiment, medicine processing method of the present invention is described in further detail.
Embodiment:
Prescription is formed:
Sanguis Naemorhedi 9g Cordyceps 2g Stigma Croci 1g dear heart blood 1g
Radix Astragali 10g Radix Polygoni Multiflori 8g Lignum Dalbergiae Odoriferae 6g Sargassum 10g
Radix Notoginseng 3g corydalis tuber 8g Venenum Bufonis 0.4g Fel Ursi 2g
Radix Salviae Miltiorrhizae 10g Ganoderma 6g Rhizoma Chuanxiong 8g Moschus 0.1g
Radix Panacis Quinquefolii 3g succinum 6g Bulbus Fritillariae Uninbracteatae 6g Borneolum Syntheticum 0.5g
All medicine choosings are clean, clean drying.
With Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali, Sargassum, Ganoderma, Radix Polygoni Multiflori, Lignum Dalbergiae Odoriferae seven flavor coarse pulverizations (crossing the 20# sieve).
It is standby that Sanguis Naemorhedi, Radix Panacis Quinquefolii, Fel Ursi, Radix Notoginseng, succinum, Bulbus Fritillariae Uninbracteatae, corydalis tuber, Cordyceps eight flavors are ground into smalls (crossing the 100# sieve).
Moschus, Venenum Bufonis, dear heart blood, Stigma Croci, Borneolum Syntheticum ground spice are broken into smalls, and (crossing the 100# sieve) is standby.
With Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali, Sargassum, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Polygoni Multiflori coarse pulverization crude drug, add the Maifanitum water dipping and spend the night, the water surface soaked group's medicine and was advisable.Next day, reflux, extract, was 2 times, and each 2 hours, merge extractive liquid, was put coldly, and precipitation is filtered, and concentrating under reduced pressure gets proportion, and to be about the extractum of 1.10-1.20 standby.
Medicinal residues behind the water extraction are used the alcohol reflux of 50%, 70%, 85%, 95% gradient concentration respectively, each 1-1.5 hour.Merge all ethanol extracts, precipitation, filtration, normal pressure reclaim ethanol, must not have the rare extractum of alcohol flavor.
Sanguis Naemorhedi, Radix Panacis Quinquefolii, Fel Ursi, Radix Notoginseng, succinum, Bulbus Fritillariae Uninbracteatae, corydalis tuber, Cordyceps eight are distinguished the flavor of medicated powder with the water extracted immersing paste and alcohol-extracted extract, mix homogeneously under the heating state, temperature maintenance mixed time 1-2 hour at 80-90 ℃, as far as possible evenly.
Thick paste is put in the stainless steel disc, and 50-60 ℃ of cold drying pulverized, and crosses the 100# sieve, and adds Moschus, Venenum Bufonis, dear heart blood, Stigma Croci, the thin medicamental pulverata of the Borneolum Syntheticum five tastes, fully mixing.
The former medicated powder of gained, encapsulated with 0.5 gram amount, divide packing.
Cross the 14-20 mesh sieve, 50-60 ℃ of cold drying or mixed thick paste is added usual excipients (as starch, dextrin etc.) make soft material to remove bulk or fine powder, gone into the tablet machine tabletting after 14-20 mesh sieve and 80 mesh sieves.
Medicine of the present invention is the natural Chinese medicines preparation, has effects such as benefiting qi and nourishing blood, blood circulation promoting and blood stasis dispelling, promoting of the circulation of QI and removing the obstruction in the collaterals, the chest stuffiness relieving eliminating phlegm, the multiple arteries and veins of analgesic therapy.Clinical observation proves; Have stronger antianginal, adjust arrhythmia, blood fat reducing and blood pressure, coronary artery dilating decreased heart rate, reduce myocardium keto consumption and suppress thrombotic effect; particularly can protect the heart effectively and protect brain; the prevention cardiovascular and cerebrovascular disease; residence is treated among the prevention protection; reach 96% in total effective north aspect all types of and each the pattern of syndrome coronary heart disease of treatment, obvious effective rate is more than 80%.
Claims (4)
1, a kind of Chinese patent medicine for the treatment of cardiovascular and cerebrovascular disease is characterized in that it is the medicament of being made by following raw material:
Rhizoma Chuanxiong 8-25 Radix Salviae Miltiorrhizae 10-30 Radix Astragali 10-30
Sargassum 8-25 Ganoderma 5-20 Moschus 0.1-0.5
Radix Polygoni Multiflori 8-25 Sanguis Naemorhedi 8-15 dear heart blood 1-5
Radix Panacis Quinquefolii 2-5 Cordyceps 1-5 Radix Notoginseng 1-5
Succinum 1-5 Fel Ursi 1-5 corydalis tuber 8-15
Bulbus Fritillariae Uninbracteatae 5-10 Flos Carthami 1-5 Lignum Dalbergiae Odoriferae 4-10
Venenum Bufonis 0.1-0.5 Borneolum Syntheticum 0.1-0.5 (consumption is a weight ratio in the side)
2,, it is characterized in that the optimum amount proportioning of raw material is according to the said Chinese patent medicine of claim 1:
Sanguis Naemorhedi 9g Cordyceps 2g Fel Ursi 2g Stigma Croci 1g
Dear heart blood 1g Radix Astragali 10g Radix Polygoni Multiflori 8g Lignum Dalbergiae Odoriferae 6g
Sargassum 10g Radix Notoginseng 3g corydalis tuber 8g Venenum Bufonis 0.4g
Radix Salviae Miltiorrhizae 10g Ganoderma 6g Rhizoma Chuanxiong 8g Moschus 0.1g
Radix Panacis Quinquefolii 3g succinum 6g Bulbus Fritillariae Uninbracteatae 6g Borneolum Syntheticum 0.5g
3, as the preparation method of claim 1 or 2 said Chinese patent medicine capsules, it is characterized in that Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali, Sargassum, Ganoderma, Radix Polygoni Multiflori, Lignum Dalbergiae Odoriferae seven flavor coarse pulverizations, Sanguis Naemorhedi, Radix Panacis Quinquefolii, Fel Ursi, Radix Notoginseng, succinum, Bulbus Fritillariae Uninbracteatae, corydalis tuber, Cordyceps eight flavors are ground into smalls, Moschus, Venenum Bufonis, dear heart blood, Stigma Croci, Borneolum Syntheticum ground spice are broken into smalls, again with the coarse pulverization crude drug of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the Radix Astragali, Sargassum, Ganoderma, Lignum Dalbergiae Odoriferae, Radix Polygoni Multiflori, add the Maifanitum water dipping and spend the night, the water surface soaked group's medicine and was advisable.Next day, reflux, extract, was 2 times, and each 2 hours, merge extractive liquid, filtered, and concentrates to such an extent that proportion is the extractum of 1.10-1.20; Medicinal residues behind the water extraction are used the alcohol reflux of 50%, 70%, 85%, 95% gradient concentration respectively, and each 1-1.5 hour, merge all ethanol extracts, filter, reclaim ethanol, must there be the rare extractum of alcohol flavor; Sanguis Naemorhedi, Radix Panacis Quinquefolii, Fel Ursi, Radix Notoginseng, succinum, Bulbus Fritillariae Uninbracteatae, corydalis tuber, Cordyceps eight are distinguished the flavor of medicated powder with the water extracted immersing paste and alcohol-extracted extract, the heating mixing, temperature maintenance is at 80-90 ℃, mix, the gained thick paste is pulverized in 50-60 ℃ of drying, crosses the 100# sieve, and add Moschus, Venenum Bufonis, dear heart blood, Stigma Croci, the abundant mixing of the thin medicamental pulverata of the Borneolum Syntheticum five tastes, encapsulated.
4, as the preparation method of the said Chinese patent medicine of claim 3, can add usual excipients, be prepared into tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93100199 CN1025774C (en) | 1992-11-14 | 1993-01-12 | Special "shanhaidan" and its production method |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92112960 | 1992-11-14 | ||
| CN92112960.2 | 1992-11-14 | ||
| CN 93100199 CN1025774C (en) | 1992-11-14 | 1993-01-12 | Special "shanhaidan" and its production method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1073875A CN1073875A (en) | 1993-07-07 |
| CN1025774C true CN1025774C (en) | 1994-08-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93100199 Expired - Fee Related CN1025774C (en) | 1992-11-14 | 1993-01-12 | Special "shanhaidan" and its production method |
Country Status (1)
| Country | Link |
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| CN (1) | CN1025774C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100339085C (en) * | 2003-09-23 | 2007-09-26 | 天津天士力制药股份有限公司 | Combination of Chinese traditional medicine for curing cardiovascular and cerebrovascular diseases |
| CN101085022B (en) * | 2006-06-08 | 2011-09-21 | 天津天士力制药股份有限公司 | Medicinal composition containing safflower and musk, preparation method and preparation |
| CN102145128B (en) * | 2011-03-30 | 2012-07-11 | 呼伦贝尔松鹿制药有限公司 | Medicinal composition for preventing and treating cardiac and cerebral vascular diseases and preparation method thereof |
| CN108903541A (en) * | 2018-09-25 | 2018-11-30 | 四川新绿色药业科技发展有限公司 | A kind of medicine-filled pillow and preparation method thereof for wind-expelling pain-stopping |
| CN110548099A (en) * | 2019-10-09 | 2019-12-10 | 辽宁帛道堂药业有限公司 | Traditional Chinese medicine composition for treating coronary heart disease stable angina pectoris and preparation method thereof |
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1993
- 1993-01-12 CN CN 93100199 patent/CN1025774C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1073875A (en) | 1993-07-07 |
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