CN102225100A - Chinese medicinal formulation for treating cardiovascular and cerebrovascular diseases and preparation process of products thereof - Google Patents
Chinese medicinal formulation for treating cardiovascular and cerebrovascular diseases and preparation process of products thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal formulation for treating cardiovascular and cerebrovascular diseases and a preparation process of products thereof. The preparation process comprises the following steps of: decocting Chinese angelica, chuanxiong rhizome, safflower, salvia miltiorrhiza, American ginseng, notoginseng, tree peony bark, earthworms, leech and gradfly; filtering; adding Zygosaccharomyces bailii to the resulting filtrate and filter residues, standing to culture in appropriate temperature and humidity environments for 168 to 240 hours, and making oral liquids, oral tablets or capsules. The main indications of the product disclosed by the invention include cardiovascular and cerebrovascular diseases, hypertension and blood diseases, and the product is directly taken, has rapid onset of action, prevents the recurrence of diseases, is absorbed rapidly, has high curative effects, is sweet in taste, and cause no sequela or complication after administration. By applying microorganisms to Chinese medicines, the two special processes of solid fermentation and liquid fermentation are achieved, so as to eliminate the toxic and adverse effects of active pharmaceutical ingredients, provide convenience for storage and administration and not produce wastes or residues. Besides, the resources of raw materials are abundant, the production is simple and low in cost, and the product is applied to both therapy and health care.
Description
Technical field
The present invention relates to the Chinese medicine technical field, relate in particular to a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease and products thereof preparation technology.
Background technology
At present, annual nearly 3,000,000 people of China die from cardiovascular disease, account for 40% of whole causes of death, be China resident's No.1 killer, the research prediction, the sickness rate male of 10 years from now on China's middle-aged population apoplexy will increase by 42%, the women will increase by 13%, Incidence of CHD male will increase by 26%, the women will increase by 19%, 2003, Chinese cardiovascular diseases's direct medical cost was 1301.17 hundred million yuan, account for the same period Chinese medical total cost and the ratio of health total cost be respectively 22.65% and 19.74%; Come preceding 3 disease kind and be respectively hypertension (366.03 hundred million yuan), coronary heart disease (264.33 hundred million yuan), cerebral infarction (237.32 hundred million yuan), the ratio that accounts for the Chinese medical total cost same period is respectively 6.37%, 4.60%, 4.13%, and the main means of present stage treatment cardiovascular and cerebrovascular disease are Western medicine and doctor trained in Western medicine operation, the state of an illness can rapidly, be effectively contained in the operation of Western medicine and doctor trained in Western medicine, but have that toxic and side effects is strong, the state of an illness repeatedly in addition serious more, cure the symptoms, not the disease, cost an arm and a leg, have problems such as sequela or complication;
Chinese medicine have treating both the principal and secondary aspects of a disease, toxic and side effects little, take unique advantages such as evident in efficacy for a long time; But exist processing technique original, the treatment onset is slow relatively, and active ingredient is difficult to quantitatively, and the taste bitterness such as is difficult to take for a long time at defective; Trace it to its cause, be difficult at first determine how many effective ingredient in the medical material can extract, the Chinese crude drug effective ingredient that boils often is wrapped in the cell wall, plant cell wall is the compact texture that is made of materials such as cellulose, hemicellulose, pectic substance, lignins, in the leaching process of middle pharmaceutically active ingredient, must overcome the dual resistance of cell wall and intercellular substance; Next uncontrollable process that digests again and decompose, because decoction that the patient takes or Chinese patent medicine, not directly to enter blood performance effect of drugs, but digest again and decompose by the human body gastrointestinal system, just can be converted into the effective ingredient that finally works and enter blood, the therapeutical effect of performance medicine;
The Chinese medicine fermentation technique has overcome the defective of Chinese medicine, makes Chinese medicine have the advantages such as utilization, curative effect is fast, drug effect is high, have no side effect, the Chinese medicine taste is adjustable that can be absorbed by the body fully, is the revolution to the Chinese medicine industry; Ancients promptly are applied to microbe fermentation method in the Chinese medicine infusion before 4,000 years, as Massa Medicata Fermentata, Pinellia leaven etc., all be to utilize the medicine that forms behind natural microorganism (as mycete, the yeast etc.) solid fermentation, because the microorganism of occurring in nature is uncontrollable, cause the not better deeply development of this technology; Along with the development of modern biotechnology, by action of microorganisms, change the original property of medicine of Chinese medicine, improve curative effect, remove toxic and side effects and extensively proposed once more, make the focus of Chinese medicine fermentation becoming modern Chinese medicine research;
Microorganism Chinese medicine fermentation technique is applied in the Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease, produce have absorb fast, curative effect is high, instant effect, nothing repeatedly, cheap, taste is sweet, be convenient to deposit, instant and the Chinese medicine finished product of taking back no sequel or complication are not seen as yet.
Summary of the invention
For addressing the above problem, the present inventor concentrates on studies by many decades, characteristic at cardiovascular and cerebrovascular disease, Chinese medicine preparation of the present invention and the unique Chinese medicine fermentation technology of combination have been proposed, a kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease and products thereof preparation technology is provided, the Chinese medicine finished product by this technical recipe preparation have absorb fast, curative effect is high, instant effect, nothing repeatedly, cheap, taste is sweet, be convenient to deposit, instant and take back no sequel or complication.
The technical solution adopted in the present invention is:
Chinese medicine preparation of the present invention is made (consumption is a weight portion) by following component
Radix Angelicae Sinensis 200～260, Rhizoma Chuanxiong 220～260, Flos Carthami 200～250, Radix Salviae Miltiorrhizae 230～250, Radix Panacis Quinquefolii 200～260, Radix Notoginseng 220～260, Cortex Moutan 200～250, Pheretima 230～250, Hirudo 230～250, awns worm 230～250.
The preparation method of said components being made product of the present invention is:
(1) with the screening of above-mentioned Chinese medicinal components process, removes impurity, add water and be warming up to 90～100 ℃, decocted 30～40 minutes;
(2) Chinese medicinal components after will decocting is cooled to 25～30 ℃, filters to obtain filtrate and medicinal residues;
(3) in last step gained filtrate, add white sugar, add white sugar and filtrate weight ratio be 1: 8～1: 10, this liquid is sent into culture medium, add Zygosaccharomyces bailii, 28～35 ℃ of design temperatures, humidity is controlled at 25%～30%, and static cultivation 168～240 hours obtains oral liquid of the present invention;
(4) second step was filtered the gained medicinal residues and add white sugar water, described white sugar water is that white sugar is melted in the mixed liquor that forms in the water fully, and the weight ratio before wherein white sugar mixes with water is 1: 10, and the weight ratio of described medicinal residues and white sugar water is 1: 0.2～1: 1;
(5) the 4th step gained mixture is put into culture medium, add Zygosaccharomyces bailii, 28～35 ℃ of design temperatures, humidity is controlled at 25%～30%, and static cultivation 168～240 hours is taken out the mixture after the fermentation air-dry, smash, obtain solid particle, can be directly oral, also can be used for making oral tablets or capsule.
Chinese medicinal components of the present invention
Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, arrhythmia, blood fat reducing and atherosclerosis;
Rhizoma Chuanxiong: the hot temperature of loosing is logical, and blood circulation promoting and blood stasis dispelling increases coronary flow, reduces myocardium keto consumption, improves myocardial metabolism;
Flos Carthami: the latus rectum of invigorating blood circulation, eliminating stasis to stop pain, penetrating blood, in order to blood pressure lowering and anoxia enduring;
Radix Salviae Miltiorrhizae: blood circulation promoting and blood stasis dispelling, nourishing blood to tranquillize the mind, removing heat from blood detumescence, in order to strengthen myocardial contraction, to improve the reparation and the regeneration of cardiac function, coronary artery dilating and peripheral blood vessel, promotion tissue;
Radix Panacis Quinquefolii: blood pressure regulation, reinforcement cardiac muscle, inhibition arteriosclerosis, the growth of promotion erythrocyte, increase hematochrome;
Radix Notoginseng: dissipating blood stasis hemostasis, subduing swelling and relieving pain, in order to promote hemopoietic, expand blood vessel, blood pressure lowering, resist myocardial ischemia, anti-cerebral ischemia, arrhythmia, atherosclerosis;
Cortex Moutan: nourishing YIN to lower pathogenic fire, separate speckle poison, throat, diuresis stasis, be used for blood pressure lowering;
Pheretima: heat clearing away, suppressing the hyperactive liver, Zhichuan, collateral dredging, be longer than current meridians, be used for the blockage of meridian that multiple reason causes, blood vessels are not smooth, the disease that podomere is unfavorable;
Hirudo: removing blood stasis, removing blood stasis, stimulate the menstrual flow, be used to increase the myocardial nutritional flow amount, promote the absorption of cephalophyma and ecchymosis, alleviate inflammatory reaction on every side and edema, alleviate intracranial pressure and raise, improve regional flow's circulation, the protection cerebral tissue exempts from necrosis and promotes the recovery of function of nervous system;
Awns worm: removing blood stasis, detumescence blood stasis dispelling.
Beneficial effect of the present invention is:
(1) product of the present invention cures mainly cardiovascular and cerebrovascular disease, hypertension, hematopathy, and the oral liquid of production is taken at different patients with tablet, and it is fast to respond well to treatment, and does not have repeatedly;
(2) the present invention is applied in by microorganism and realizes solid and two kinds of special process of liquid fermentation on the Chinese medicine, not only remove the toxic and side effects of former medicine, and product is convenient to deposit, instant, does not produce discarded medicinal residues simultaneously, and raw material of Chinese medicine is fully used;
(3) the raw material of Chinese medicine source is abundant, and manufacture method is simple, and is with low cost;
(4) tcm product of making after by fermentation is directly oral, absorb fast, curative effect is high, taste is sweet, and takes back no sequel or complication, can treat and can keep healthy, and has or not disease all can take.
The specific embodiment
Embodiment 1:
Chinese medicine preparation of the present invention is made (consumption is a weight portion) by following component
Radix Angelicae Sinensis 200, Rhizoma Chuanxiong 220, Flos Carthami 200, Radix Salviae Miltiorrhizae 230, Radix Panacis Quinquefolii 200, Radix Notoginseng 220, Cortex Moutan 200, Pheretima 230, Hirudo 230, awns worm 230.
The preparation method of said components being made product of the present invention is:
(1) with the screening of above-mentioned Chinese medicinal components process, removes impurity, add water and be warming up to 90 ℃, decocted 40 minutes;
(2) Chinese medicinal components after will decocting is cooled to 25 ℃, filters to obtain filtrate and medicinal residues;
(3) in last step gained filtrate, add white sugar, add white sugar and filtrate weight ratio be 1: 8, this liquid is sent into culture medium, add Zygosaccharomyces bailii, 28 ℃ of design temperatures, humidity is controlled at 25%, static cultivation 240 hours obtains oral liquid of the present invention;
(4) second step was filtered the gained medicinal residues and add white sugar water, described white sugar water is that white sugar is melted in the mixed liquor that forms in the water fully, and the weight ratio before wherein white sugar mixes with water is 1: 10, and the weight ratio of described medicinal residues and white sugar water is 1: 0.2;
(5) the 4th step gained mixture is put into culture medium, add Zygosaccharomyces bailii, 28 ℃ of design temperatures, humidity is controlled at 25%, static cultivation 240 hours, the taking-up of the mixture after the fermentation is air-dry, smash, obtain solid particle, can be directly oral, also can be used for making oral tablets or capsule.
In culture medium; but Zygosaccharomyces bailii is tens kinds of enzyme materials such as extracellular proteinase, cellulase, hemicellulase, pectase, amylase in metabolic process; these enzyme materials are with the ingredient decomposition and inversion; effective ingredient is fully separated out; and the protection of the temperature that sweat is set, the very big degree of humidity active ingredient of Chinese herbs exempt from destruction; particularly to the active component of heat sensitive aromatics and vitamins, the more effective protection.As taking of oral liquid, once oral 5ml gets final product clinic trial 100 examples three times on the one, male's 77 examples wherein, women's 23 examples have been cured 83 examples, and remaining 17 examples all have in various degree and take a turn for the better, still in continuing to take medicine, because of the ill degree difference of patient, required to take number of times also different; As seen product of the present invention has specially good effect to cardiovascular and cerebrovascular disease, hypertension, hemopathic prevention and treatment; And because Chinese medicine preparation Chinese crude drug cheap, and processing technology is simple, has alleviated patient's medical expense greatly, benefits the nation and the people.
Embodiment 2:
Chinese medicine preparation of the present invention is made (consumption is a weight portion) by following component
Radix Angelicae Sinensis 260, Rhizoma Chuanxiong 260, Flos Carthami 250, Radix Salviae Miltiorrhizae 250, Radix Panacis Quinquefolii 260, Radix Notoginseng 260, Cortex Moutan 250, Pheretima 250, Hirudo 250, awns worm 250.
The preparation method of said components being made product of the present invention is:
(1) with the screening of above-mentioned Chinese medicinal components process, removes impurity, add water and be warming up to 100 ℃, decocted 30 minutes;
(2) Chinese medicinal components after will decocting is cooled to 30 ℃, filters to obtain filtrate and medicinal residues;
(3) in last step gained filtrate, add white sugar, add white sugar and filtrate weight ratio be 1: 10, this liquid is sent into culture medium, add Zygosaccharomyces bailii, 35 ℃ of design temperatures, humidity is controlled at 30%, static cultivation 168 hours obtains oral liquid of the present invention;
(4) second step was filtered the gained medicinal residues and add white sugar water, described white sugar water is that white sugar is melted in the mixed liquor that forms in the water fully, and the weight ratio before wherein white sugar mixes with water is 1: 10, and the weight ratio of described medicinal residues and white sugar water is 1: 1;
(5) the 4th step gained mixture is put into culture medium, add Zygosaccharomyces bailii, 35 ℃ of design temperatures, humidity is controlled at 30%, static cultivation 168 hours, the taking-up of the mixture after the fermentation is air-dry, smash, obtain solid particle, can be directly oral, also can be used for making oral tablets or capsule.
The using method of products obtained therefrom is with embodiment 1.
Embodiment 3
Chinese medicine preparation of the present invention is made (consumption is a weight portion) by following component
Radix Angelicae Sinensis 250, Rhizoma Chuanxiong 250, Flos Carthami 250, Radix Salviae Miltiorrhizae 250, Radix Panacis Quinquefolii 250, Radix Notoginseng 250, Cortex Moutan 250, Pheretima 250, Hirudo 250, awns worm 250.
The preparation method of said components being made product of the present invention is:
(1) with the screening of above-mentioned Chinese medicinal components process, removes impurity, add water and be warming up to 98 ℃, decocted 35 minutes;
(2) Chinese medicinal components after will decocting is cooled to 28 ℃, filters to obtain filtrate and medicinal residues;
(3) in last step gained filtrate, add white sugar, add white sugar and filtrate weight ratio be 1: 9, this liquid is sent into culture medium, add Zygosaccharomyces bailii, 30 ℃ of design temperatures, humidity is controlled at 28%, static cultivation 210 hours obtains oral liquid of the present invention;
(4) second step was filtered the gained medicinal residues and add white sugar water, described white sugar water is that white sugar is melted in the mixed liquor that forms in the water fully, and the weight ratio before wherein white sugar mixes with water is 1: 10, and the weight ratio of described medicinal residues and white sugar water is 1: 0.6;
(5) the 4th step gained mixture is put into culture medium, add Zygosaccharomyces bailii, 30 ℃ of design temperatures, humidity is controlled at 28%, static cultivation 230 hours, the taking-up of the mixture after the fermentation is air-dry, smash, obtain solid particle, can be directly oral, also can be used for making oral tablets or capsule.
The using method of products obtained therefrom is with embodiment 1.
The explanation of above embodiment only is used to understand principle of the present invention, is not understood to limitation of the present invention.
Claims (4)
1. Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease and products thereof preparation technology, it is characterized in that: Chinese medicine preparation is made (consumption is a weight portion) by following component
Radix Angelicae Sinensis 200～260, Rhizoma Chuanxiong 220～260, Flos Carthami 200～250, Radix Salviae Miltiorrhizae 230～250, Radix Panacis Quinquefolii 200～260, Radix Notoginseng 220～260, Cortex Moutan 200～250, Pheretima 230～250, Hirudo 230～250, awns worm 230～250.
2. the Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease according to claim 1 and products thereof preparation technology is characterized in that: Chinese medicine preparation is made (consumption is a weight portion) by following component
Radix Angelicae Sinensis 250, Rhizoma Chuanxiong 250, Flos Carthami 250, Radix Salviae Miltiorrhizae 250, Radix Panacis Quinquefolii 250, Radix Notoginseng 250, Cortex Moutan 250, Pheretima 250, Hirudo 250, awns worm 250.
3. Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease and products thereof preparation technology, it is characterized in that: the preparation method of described Chinese medicinal components being made product is
(1) with the screening of above-mentioned Chinese medicinal components process, removes impurity, add water and be warming up to 90～100 ℃, decocted 30～40 minutes;
(2) Chinese medicinal components after will decocting is cooled to 25～30 ℃, filters to obtain filtrate and medicinal residues;
(3) in last step gained filtrate, add white sugar, add white sugar and filtrate weight ratio be 1: 8～1: 10, this liquid is sent into culture medium, add Zygosaccharomyces bailii, 28～35 ℃ of design temperatures, humidity is controlled at 25%～30%, and static cultivation 168～240 hours obtains oral liquid of the present invention;
(4) second step was filtered the gained medicinal residues and add white sugar water, described white sugar water is that white sugar is melted in the mixed liquor that forms in the water fully, and the weight ratio before wherein white sugar mixes with water is 1: 10, and the weight ratio of described medicinal residues and white sugar water is 1: 0.2～1: 1;
(5) the 4th step gained mixture is put into culture medium, add Zygosaccharomyces bailii, 28～35 ℃ of design temperatures, humidity is controlled at 25%～30%, and static cultivation 168～240 hours is taken out the mixture after the fermentation air-dry, smash, obtain solid particle, can be directly oral, also can be used for making oral tablets or capsule.
4. the Chinese medicine preparation of treatment cardiovascular and cerebrovascular disease according to claim 3 and products thereof preparation technology is characterized in that: the preparation method that described Chinese medicinal components is made product is
(1) with the screening of above-mentioned Chinese medicinal components process, removes impurity, add water and be warming up to 98 ℃, decocted 35 minutes;
(2) Chinese medicinal components after will decocting is cooled to 28 ℃, filters to obtain filtrate and medicinal residues;
(3) in last step gained filtrate, add white sugar, add white sugar and filtrate weight ratio be 1: 9, this liquid is sent into culture medium, add Zygosaccharomyces bailii, 30 ℃ of design temperatures, humidity is controlled at 28%, static cultivation 210 hours obtains oral liquid of the present invention;
(4) second step was filtered the gained medicinal residues and add white sugar water, described white sugar water is that white sugar is melted in the mixed liquor that forms in the water fully, and the weight ratio before wherein white sugar mixes with water is 1: 10, and the weight ratio of described medicinal residues and white sugar water is 1: 0.6;
(5) the 4th step gained mixture is put into culture medium, add Zygosaccharomyces bailii, 30 ℃ of design temperatures, humidity is controlled at 28%, static cultivation 230 hours, the taking-up of the mixture after the fermentation is air-dry, smash, obtain solid particle, can be directly oral, also can be used for making oral tablets or capsule.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306615A (en) * | 2014-09-30 | 2015-01-28 | 韩奎 | Medicine for treating coronary heart disease and preparation method of medicine |
| CN104435955A (en) * | 2014-11-10 | 2015-03-25 | 戴启亮 | Biological fermentation water plaster and preparation method of plaster |
| CN105456390A (en) * | 2015-12-17 | 2016-04-06 | 夏修菲 | Clinical mixed preparation for cardiovascular department and preparation method |
| CN106236833A (en) * | 2016-09-21 | 2016-12-21 | 杨永久 | A kind of pharmaceutical composition treating cardiovascular and cerebrovascular disease |
| CN107714857A (en) * | 2017-12-01 | 2018-02-23 | 王章琳 | A kind of Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN112656883A (en) * | 2020-12-21 | 2021-04-16 | 黑龙江儒泰科技发展有限责任公司 | Blood-activating traditional Chinese medicine composition and application thereof |
-
2011
- 2011-06-04 CN CN2011101596210A patent/CN102225100A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306615A (en) * | 2014-09-30 | 2015-01-28 | 韩奎 | Medicine for treating coronary heart disease and preparation method of medicine |
| CN104435955A (en) * | 2014-11-10 | 2015-03-25 | 戴启亮 | Biological fermentation water plaster and preparation method of plaster |
| CN105456390A (en) * | 2015-12-17 | 2016-04-06 | 夏修菲 | Clinical mixed preparation for cardiovascular department and preparation method |
| CN106236833A (en) * | 2016-09-21 | 2016-12-21 | 杨永久 | A kind of pharmaceutical composition treating cardiovascular and cerebrovascular disease |
| CN107714857A (en) * | 2017-12-01 | 2018-02-23 | 王章琳 | A kind of Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN112656883A (en) * | 2020-12-21 | 2021-04-16 | 黑龙江儒泰科技发展有限责任公司 | Blood-activating traditional Chinese medicine composition and application thereof |
| CN112656883B (en) * | 2020-12-21 | 2022-01-28 | 黑龙江儒泰科技发展有限责任公司 | Traditional Chinese medicine composition for treating ischemic cerebrovascular disease and application thereof |
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Application publication date: 20111026 |