CN1724000A - Injection for treating cardiovascular and cerebrovascular diseases, and its prepn. method - Google Patents
Injection for treating cardiovascular and cerebrovascular diseases, and its prepn. method Download PDFInfo
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- CN1724000A CN1724000A CN 200410070723 CN200410070723A CN1724000A CN 1724000 A CN1724000 A CN 1724000A CN 200410070723 CN200410070723 CN 200410070723 CN 200410070723 A CN200410070723 A CN 200410070723A CN 1724000 A CN1724000 A CN 1724000A
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Abstract
A Chinese medicine in the form of injection for treating the ischemic cardiovascular and cerebrovascular diseases, such as cerebral infarction, cerebral thrombosis, apoplexy sequel, coronary heart disease and angina pectoris, is prepared from motherwort (5-95 wt%) and one or more of astragalus root, notoginseng and leech (5-95 wt%). Its preparing process is also disclosed.
Description
Technical field
The present invention is a kind of injection and preparation method that is used for cardiovascular and cerebrovascular vessel, belongs to the field of Chinese medicines.
Background technology
Along with social senilization and growth in the living standard, the sickness rate and the case fatality rate of cardiovascular and cerebrovascular disease rise day by day.Studies show that according to nearest one, comprise that in 8 major areas, the whole world investigation of both developed and developing country shows that ischemic heart desease and cerebrovascular disease have become the main cause of death.As in the U.S., cardiovascular disease far surpasses cancer, accounts for 42% of whole death, becomes underlying cause of death.In China, cardiovascular and cerebrovascular disease also becomes one of old people's common frdquently encountered disease, cerebrovascular disease especially, and prevalence is up to 491.8/10 ten thousand people, apparently higher than western countries.Thrombosis is the major reason of cardiovascular and cerebrovascular vessel morbidity, so blood circulation promoting and blood stasis dispelling just becomes the key of these diseases of treatment.
Herba Leonuri mainly contains chemical compounds such as alkaloids, flavonoid, Diterpenes, volatile oil; pharmacological research proves that it has effects such as regulating menstruation, hemostasis, protection myocardial ischemia reperfusion injury, antiplatelet aggregation, reduction blood viscosity; but a effect mostly clinically with its gynecology; its effect exploitation not yet in effect at treating cardiac and cerebral vascular diseases; and a kind of or several compatibilities in the medicine such as Herba Leonuri and the Radix Astragali, Radix Notoginseng, Hirudo; strengthen the curative effect of its function of promoting blood circulation to disperse blood clots, and effectively protect brain cell.
Summary of the invention
The purpose of this invention is to provide a kind of injection and preparation method that is used for cardiovascular and cerebrovascular vessel, this medicine blood circulation promoting and blood stasis dispelling, invigorating qi and dredging collateral is used for ischemic cardio cerebrovascular diseases.This process for preparing medicine is simple, is easy to promotion and implementation.The present invention constitutes like this: it is formulated by the Herba Leonuri extraction, and the Herba Leonuri weight ratio is 5%～95%.Also a kind of in the Herba Leonuri and the Radix Astragali, Radix Notoginseng, the Hirudo or several are formulated, a kind of or shared weight ratio of several compositions in the Radix Astragali, Radix Notoginseng, the Hirudo is 5%～95%.This preparation method that is used for the injection of cardiovascular and cerebrovascular vessel is: to scale the extracting solution of Herba Leonuri is added injection solvent commonly used (can be a kind of of water, ethanol, glycerol etc. or several mix), adjuvant (can be a kind of in isoosmotic adjusting agent, cosolvent, antioxidant, PH regulator, the excipient etc. or several mix), existing routinely preparation technique is made into injection or freeze-dried powder; Also can be to scale with a kind of or several compatibilities in Herba Leonuri extracting solution and Radix Astragali extractive solution, Radix Notoginseng extracting solution, the Hirudo extract, add injection solvent commonly used (can be a kind of in water, ethanol, the glycerol etc. or several mix), adjuvant (can be a kind of in isoosmotic adjusting agent, cosolvent, antioxidant, PH regulator, the excipient etc. or several mix), existing routinely preparation technique is made into injection or freeze-dried powder.In this injection, can add adjuvant and also can not add any adjuvant.Can also be with after a kind of or several mixed extraction in Herba Leonuri or fresh Herba Leonuri and the Radix Astragali, Radix Notoginseng, the Hirudo, add injection solvent commonly used (can be a kind of in water, ethanol, the glycerol etc. or several mix), adjuvant (can be a kind of in isoosmotic adjusting agent, cosolvent, antioxidant, PH regulator, the excipient etc. or several mix), existing routinely preparation technique is made into injection or freeze-dried powder.
The Herba Leonuri extracting solution can be a Herba Leonuri dry product extract, can also be the fresh Herba Leonuri extract.Also extracting solution can be made solid extract as raw material.The Herba Leonuri solid extract can also be its effective site, also can be effective ingredient.The Radix Notoginseng extracting solution also can be made solid extract.Solid extract can also be its effective site, also can be effective ingredient.
Innovation of the present invention and novel part are: the injection of Herba Leonuri being made single component or compound recipe composition, be used for cardiovascular and cerebrovascular disease, and effective site and content of effective in the Herba Leonuri have quantitatively been controlled, motherwort formulation ratio with existing listing, widened its purposes, and the quality of production is controlled easily.Be made into freeze-dried powder and make the medicine quality of production more stable, long shelf-life transports more convenient.
The medicine of making is used for ischemic cardio cerebrovascular diseases, as cerebral infarction, cerebral thrombosis, apoplexy sequela, coronary heart disease, angina pectoris etc.
The specific embodiment
The present invention is folk prescription or compound preparation according to prescription, and the injection that is used for the treatment of cardiovascular and cerebrovascular vessel can have different preparation methoies:
1, with the Herba Leonuri extracting solution be the injection of feedstock production, the weight ratio of Herba Leonuri is 5%～95%.
2, with after a kind of or several mixed extraction in Herba Leonuri and the Radix Astragali, Radix Notoginseng, the Hirudo, be prepared into injection, a kind of in the Radix Astragali, Radix Notoginseng, the Hirudo or several weight ratio are 5%～95%.
3, with a kind of or several compatibilities in Herba Leonuri extracting solution and Radix Astragali extractive solution, Radix Notoginseng extracting solution, the Hirudo extract, be prepared into injection, a kind of in the Radix Astragali, Radix Notoginseng, the Hirudo or several weight ratio are 5%～95%
Embodiments of the invention 1: get Herba Leonuri 1000g, decoct with water three times, collecting decoction filters, and it is 1.25～1.35 clear paste that filtrate decompression is concentrated into relative density, and the ethanol precipitate with ethanol with 80%～95% leaves standstill, and filters, and reclaims ethanol, as the Herba Leonuri extracting solution.Get the Herba Leonuri extracting solution, add 0.5% sodium sulfite, add the injection water and make into and contain Herba Leonuri total alkaloids 20mg～40mg among the 1ml as antioxidant, add active carbon (consumption is 0.01%～0.5%) absorption again, coarse filtration is taken off charcoal, fine straining, embedding, sterilization, promptly.
Embodiments of the invention 2: get Herba Leonuri total alkaloids 5g, add 0.5% sodium sulfite as antioxidant, adding the injection water makes into and contains Herba Leonuri total alkaloids 20mg～40mg among the 1ml, regulating pH value with the PH regulator is 4.0～6.0, adds active carbon (consumption is 0.01%～0.5%) absorption again, and coarse filtration is taken off charcoal, fine straining, embedding, sterilization, promptly.
Embodiments of the invention 3: get embodiment 1,2 described Herba Leonuri extracting solution or Herba Leonuri total alkaloidss, add 0.5% sodium sulfite as antioxidant, the sodium chloride that adds 5% glucose or 0.9% again is as isoosmotic adjusting agent, and add the injection water and make into and contain Herba Leonuri total alkaloids 0.20mg～0.40mg among the 1ml, be 4.0～6.0 with PH regulator adjusting pH value, add active carbon (consumption is 0.01%～0.5%) absorption again, coarse filtration is taken off charcoal, fine straining, embedding, sterilization, promptly.
Embodiments of the invention 4: get embodiment 1,2 described Herba Leonuri extracting solution or Herba Leonuri total alkaloidss, add 0.5% sodium sulfite as antioxidant, adding the injection water makes into and contains Herba Leonuri total alkaloids 20mg～40mg among the 1ml, regulating pH value with the PH regulator is 4.0～6.0, add active carbon (consumption is 0.01%～0.5%) absorption again, coarse filtration is taken off charcoal, is made into freeze-dried powder by prior art, can also add mannitol or excipient such as glucose or sodium chloride in said preparation.
Embodiments of the invention 5: get Herba Leonuri 1000g, Radix Astragali 1000g, Radix Notoginseng 200g, Hirudo 100g, decoct with water after the mixing three times, collecting decoction filters, it is 1.25～1.35 clear paste that filtrate decompression is concentrated into relative density, ethanol precipitate with ethanol with 80%～95% leaves standstill, and filters, reclaim ethanol, add 0.5% sodium sulfite as antioxidant, add the injection water and make into and contain Herba Leonuri total alkaloids 0.20mg～40mg among the 1ml, add active carbon (consumption is 0.01%～0.5%) absorption again, coarse filtration is taken off charcoal, is made into injection (little pin by prior art, infusion solutions) or freeze-dried powder.
Embodiments of the invention 6: get Herba Leonuri 1000g, Radix Astragali 1000g, decoct with water after the mixing three times, collecting decoction, filter, it is 1.25～1.35 clear paste that filtrate decompression is concentrated into relative density, ethanol precipitate with ethanol with 80%～95% leaves standstill, and filters, reclaim ethanol, add 0.5% sodium sulfite as antioxidant, add the injection water and make into and contain Herba Leonuri total alkaloids 20mg～40mg among the 1ml, add active carbon (consumption is 0.01%～0.5%) absorption again, coarse filtration is taken off charcoal, is made into injection (little pin, infusion solutions) or freeze-dried powder by prior art.
Embodiments of the invention 7: get Herba Leonuri 1000g, Radix Astragali 1000g, Hirudo 100g, decoct with water after the mixing three times, collecting decoction, filter, it is 1.25～1.35 clear paste that filtrate decompression is concentrated into relative density, the ethanol precipitate with ethanol with 80%～95%, leave standstill, filter, reclaim ethanol, add 0.5% sodium sulfite as antioxidant, adding the injection water makes into and contains Herba Leonuri total alkaloids 0.20mg～40mg among the 1ml, add active carbon (consumption is 0.01%～0.5%) absorption again, coarse filtration is taken off charcoal, is made into injection (little pin by prior art, infusion solutions) or freeze-dried powder.
Embodiments of the invention 8: get Radix Astragali 1000g, decoct with water collecting decoction three times, filter, filtrate decompression is concentrated into every 1ml and is equivalent to crude drug 1～2g, the ethanol precipitate with ethanol with 80%～95%, leave standstill, filter, reclaim ethanol, and be concentrated into every 1ml and be equivalent to crude drug 1g, cold preservation was left standstill 24 hours, filter, filtrate is concentrated into every 1ml and is equivalent to crude drug 5g, as Radix Astragali extractive solution.Get embodiment 1,2 described Herba Leonuri extracting solution or Herba Leonuri total alkaloidss, with Radix Astragali extractive solution or Radix Astragali saponin compatibility, add 0.5% sodium sulfite as antioxidant, adding the injection water makes into and contains Herba Leonuri total alkaloids 20mg～40mg among the 1ml, contain Radix Astragali total saponins 5mg～20mg, regulating pH value with the PH regulator is 4.0～6.0, add active carbon (consumption is 0.01%～0.5%) absorption again, coarse filtration is taken off charcoal, be made into freeze-dried powder by prior art, in said preparation, can also add mannitol or excipient such as glucose or sodium chloride.
Among the present invention, contain chemical compounds such as alkaloids, flavonoid, Diterpenes, volatile oil in the Herba Leonuri extract, pharmacological research proves that it has effects such as regulating menstruation, hemostasis, protection myocardial ischemia reperfusion injury, antiplatelet aggregation, reduction blood viscosity, is used for the ischemic cardio cerebrovascular diseases curative effect and is better than FUFANG DANSHEN ZHUSHEYE; Contain chemical compounds such as Radix Astragali total saponins, total flavones, polysaccharide in the Radix Astragali extract, the pharmacological research proof has effects such as tonifying Qi and lifting yang, benefiting QI for strengthening the superficies, promoting the production of body fluid to quench thirst, promoting pus discharge and tissue regeneration strengthening and inducing diuresis to remove edema.Continue to use with a long historyly because of it, the curative effect successive dynasties do not wane, so be widely used in clinical each section, the Radix Astragali is a medicine multipotency.The Radix Astragali and Herba Leonuri compatibility play a protective role to rats with cerebral ischemia synapse structure, alleviate brain injury.Hirudo or Radix Notoginseng are the medicine of removing blood stasis, thrombolytic effect; thrombolytic is rapid; add effects such as Herba Leonuri antiplatelet aggregation, reduction blood viscosity; anti-tampon forms again; add the Radix Astragali again, not only brain cell is played a protective role, all right invigorating the spleen and replenishing QI; the human body immunity improving resistance has significant curative effect to ischemic cardio cerebrovascular diseases.
Claims (10)
1, a kind of injection and preparation method that is used for cardiovascular and cerebrovascular vessel, it is characterized in that: it is formulated by containing Herba Leonuri, and it contains Herba Leonuri, and to extract shared weight ratio be 5%～95%.
2, a kind of injection and preparation method that is used for cardiovascular and cerebrovascular vessel according to claim 1, it is characterized in that: described injection is injection or freeze-dried powder.
3, a kind of injection and preparation method that is used for cardiovascular and cerebrovascular vessel according to claim 1, it is characterized in that: Herba Leonuri also can with a kind of or several compatibilities in the Radix Astragali, Radix Notoginseng, the Hirudo, a kind of or shared weight ratio of several compositions in the Radix Astragali, Radix Notoginseng, the Hirudo is 5%～95%.
4, according to claim 1 and 2 described a kind of injection and preparation methoies that are used for cardiovascular and cerebrovascular vessel, it is characterized in that: to scale the extracting solution of Herba Leonuri is added injection solvent commonly used (can be a kind of in water, ethanol, the glycerol etc. or several mix), adjuvant (can be a kind of in isoosmotic adjusting agent, cosolvent, antioxidant, PH regulator, the excipient etc. or several mix), existing routinely preparation technique is made into injection or freeze-dried powder.
5, according to claim 2 and 3 described a kind of injection and preparation methoies that are used for cardiovascular and cerebrovascular vessel, it is characterized in that: to scale a kind of or several compatibilities in Herba Leonuri extracting solution thing and Radix Astragali extractive solution, Radix Notoginseng extracting solution, the Hirudo extract are added injections solvent commonly used (can be a kind of in water, ethanol, the glycerol etc. or several mix), adjuvant (can be a kind of in isoosmotic adjusting agent, cosolvent, antioxidant, PH regulator, the excipient etc. or several mix), existing routinely preparation technique is made into injection or freeze-dried powder.
6, according to claim 4 and 5 described a kind of injection and preparation methoies that are used for cardiovascular and cerebrovascular vessel, it is characterized in that: outside desolventizing, in this injection, can add adjuvant and also can not add any adjuvant.
7, according to claim 4 and 5 described a kind of injection and preparation methoies that are used for cardiovascular and cerebrovascular vessel, it is characterized in that: described Herba Leonuri extracting solution can be a Herba Leonuri dry product extract, can also be the fresh Herba Leonuri extract, also extracting solution can be made solid extract as raw material.
8, a kind of injection and preparation method that is used for cardiovascular and cerebrovascular vessel according to claim 7, it is characterized in that: described Herba Leonuri solid extract can also be its effective site, also can be effective ingredient.
9, a kind of injection and preparation method that is used for cardiovascular and cerebrovascular vessel according to claim 5, it is characterized in that: the described Radix Astragali, Radix Notoginseng, Hirudo extracting solution also can be made solid extract, solid extract can also be its effective site, also can be effective ingredient.
10, according to described a kind of injection and the preparation method that is used for cardiovascular and cerebrovascular vessel of claim 1-3, it is characterized in that: can also be after a kind of or several mixed extraction in Herba Leonuri or fresh Herba Leonuri and the Radix Astragali, Radix Notoginseng, the Hirudo, add injection solvent commonly used (can be a kind of in water, ethanol, the glycerol etc. or several mix), adjuvant (can be a kind of in isoosmotic adjusting agent, cosolvent, antioxidant, PH regulator, the excipient etc. or several mix), existing routinely preparation technique is made into injection or freeze-dried powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410070723 CN1724000A (en) | 2004-07-22 | 2004-07-22 | Injection for treating cardiovascular and cerebrovascular diseases, and its prepn. method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410070723 CN1724000A (en) | 2004-07-22 | 2004-07-22 | Injection for treating cardiovascular and cerebrovascular diseases, and its prepn. method |
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| Publication Number | Publication Date |
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| CN1724000A true CN1724000A (en) | 2006-01-25 |
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| CN 200410070723 Pending CN1724000A (en) | 2004-07-22 | 2004-07-22 | Injection for treating cardiovascular and cerebrovascular diseases, and its prepn. method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512493A (en) * | 2006-11-08 | 2012-06-27 | 复旦大学 | Use of motherwort aqueous extract in preparation of drug for treating ischemic heart disease |
| CN103211809A (en) * | 2013-04-25 | 2013-07-24 | 成都中医药大学 | Application of terpenoid |
| CN104547021A (en) * | 2014-12-29 | 2015-04-29 | 河南九势生物制药有限公司 | Compound motherwort herb mixture as well as preparation method and application thereof in treatment of gynecological diseases |
| CN109793813A (en) * | 2017-11-17 | 2019-05-24 | 成都中医药大学 | Purposes of the motherwort n-butanol extract in the drug that preparation has angiogenesispromoting effect |
| CN109806293A (en) * | 2017-11-20 | 2019-05-28 | 成都中医药大学 | Purposes of the motherwort total alkaloid in the drug that preparation has angiogenesispromoting effect |
-
2004
- 2004-07-22 CN CN 200410070723 patent/CN1724000A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512493A (en) * | 2006-11-08 | 2012-06-27 | 复旦大学 | Use of motherwort aqueous extract in preparation of drug for treating ischemic heart disease |
| CN103211809A (en) * | 2013-04-25 | 2013-07-24 | 成都中医药大学 | Application of terpenoid |
| CN103211809B (en) * | 2013-04-25 | 2014-08-27 | 成都中医药大学 | Application of terpenoid |
| CN104547021A (en) * | 2014-12-29 | 2015-04-29 | 河南九势生物制药有限公司 | Compound motherwort herb mixture as well as preparation method and application thereof in treatment of gynecological diseases |
| CN109793813A (en) * | 2017-11-17 | 2019-05-24 | 成都中医药大学 | Purposes of the motherwort n-butanol extract in the drug that preparation has angiogenesispromoting effect |
| CN109806293A (en) * | 2017-11-20 | 2019-05-28 | 成都中医药大学 | Purposes of the motherwort total alkaloid in the drug that preparation has angiogenesispromoting effect |
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