CN1827138A - Chinese medicine composition prescription for treating cardiovascular and cerebrovascular diseases and preparation technique thereof - Google Patents
Chinese medicine composition prescription for treating cardiovascular and cerebrovascular diseases and preparation technique thereof Download PDFInfo
- Publication number
- CN1827138A CN1827138A CN 200510021869 CN200510021869A CN1827138A CN 1827138 A CN1827138 A CN 1827138A CN 200510021869 CN200510021869 CN 200510021869 CN 200510021869 A CN200510021869 A CN 200510021869A CN 1827138 A CN1827138 A CN 1827138A
- Authority
- CN
- China
- Prior art keywords
- fructus hippophae
- chinese medicine
- medicine composition
- parts
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a Chinese medicine composition prescription for treating cardiovascular and cerebrovascular diseases and preparation process, wherein the Chinese medicinal composition comprises raw materials and auxiliary material, the raw materials include seabuckthorn fruit extract 1-6 parts, rhizome of Sichuan lovage 1-6 parts, root of red rooted saliva 1-6 parts, banksia rose 1-6 parts, red peony root 1-6 parts, safflower 1-6 parts, haw 1-6 parts, and flatsedge tuber 1-6 parts.
Description
[technical field]
The present invention relates to technical field of Chinese medicines, is a kind of prescription and preparation technology thereof who treats the Chinese medicine composition of cardiovascular and cerebrovascular disease.
[background technology]
Human life and health in the serious threat of cardiovascular and cerebrovascular disease such as coronary heart disease, angina pectoris.China's population 1,300,000,000, the cardiovascular and cerebrovascular disease patient has surpassed 4,000 ten thousand.And coronary heart disease has become China three one of reason of dying of illness greatly.So it is very necessary to prevent and treat the research of this class disease.It also is the emphasis of studying both at home and abroad.Motherland's medical science thinks that qi depression to blood stasis is a main cause of cardiovascular and cerebrovascular disease morbidity.Except that Fructus Hippophae extract (Fructus Hippophae flavone), other seven flavor is the Chinese crude drug of the special for treating cardiovascular and cerebrovascular disease used always among the present invention, Flos Carthami for example, its drug effect promoting blood circulation to restore menstrual flow, blood-activating analgetic.Be used for multiple disturbance of blood circulation disease, water solublity is effectively formed part and is Carthamus yellow; Similar to other medical material, so determined curative effect, reliable.But also have clinically because of medical material and the caused part side effect of preparation characteristic, as constipation, dry mouth is dry and astringent in addition nose bleeding is arranged, disease such as have blood in stool, especially easily occur in the SOUTHERN CHINA various places.This prescription uses natural Fructus Hippophae extract (Fructus Hippophae flavone), property of medicine gentleness, nontoxic, can reduce the fill a prescription recipe quantity of clinical use of other medicinal herbs most in use, when keeping even strengthening its original medical material formula for treating effect, improve the prescription property of medicine, lowered the incidence rate of side reaction side effect, improved the suitability that the patient uses this medicine disease preventing and treating, improve the therapeutic index of medicine, significantly strengthened its safety.Simultaneously, because the anoxia enduring characteristic of Fructus Hippophae extract (Fructus Hippophae flavone) can be used for especially treating multiple, sudden cerebral ischemia at other medicinal herbs most in use, when cerebral infarction is waited indefinitely disease, obtain more effective stronger auxiliary support.
Through the document Investigation inspection, do not see this Chinese medicine compound composition prescription and preparation technology's thereof report.
[summary of the invention]
The objective of the invention is rule and mechanism, a kind of Chinese medicine composition prescription and preparation technology who treats cardiovascular and cerebrovascular disease is provided according to Chinese medicine and crude drug.
For achieving the above object, design a kind of Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease, comprise raw material and adjuvant, the compositions proportioning that it is characterized in that raw material prescription for 1～6 part of (1) Fructus Hippophae extract (Fructus Hippophae flavone),, 1～6 part of (2) Rhizoma Chuanxiong, 1～6 part of (3) Radix Salviae Miltiorrhizae, 1～6 part of (4) Radix Aucklandiae, 1～6 part of (5) Radix Paeoniae Rubra, 1～6 part on (6) Flos Carthami, 1～6 part of (7) Fructus Crataegi, 1～6 part of (8) Rhizoma Cyperi and adjuvant thereof form.This Chinese medicine composition can make mixture, granule, drop pill, oral liquid, tablet, capsule or injection or other accommodable clinically system type according to corresponding preparation technology; Its preparation technology includes but not limited to following preparation process: (1) preparation of raw material: get Fructus Hippophae extract (Fructus Hippophae flavone) 25g, Rhizoma Chuanxiong 125g, Radix Salviae Miltiorrhizae 250g, Radix Aucklandiae 65g, Radix Paeoniae Rubra 125g, Flos Carthami 125g, Fructus Crataegi 35g, Rhizoma Cyperi 65g; (2) extract: abovely except that Fructus Hippophae extract (Fructus Hippophae flavone), seven distinguish the flavor of, add decocting three times, each 1.5～2 hours, collecting decoction, filtration; (3) concentrate: filtrate low temperature (below 50 ℃) in centrifugal-film evaporator concentrate or other decompression cryogenic conditions under to be concentrated into relative density be 1.05～1.35 clear paste; (4) batch mixing: clear paste adds above-mentioned Fructus Hippophae extract (Fructus Hippophae flavone), and auxiliary materials and mixing such as lactose; (5) drying and granulating: can adopt vacuum spray drying or batch (-type) fluid bed drying (6) preparation of granulating: tabletting or fill capsule: make in flakes or 1000 of capsules promptly.
Present composition sample has carried out pharmacodynamics and acute toxicity test thereof, and wherein the pharmacodynamics method is: (1) thrombus model: mouse tail vein injection collagen mixes the system bolt method of inducing with epinephrine; (2) focal cerebral ischemia: line bolt method; (3) chemical cerebral anoxia: NaNo
2Hypodermic injection; (4) to the effect of chmice acute hypoxia protection: the method for dehiscing breaks end.PRELIMINARY RESULTS shows: the present invention's safety coefficient height of writing out a prescription, and several avirulences, the medication dosis tolerata is big; Has anti thrombotic action; Can prolong to breathe and hold time, cerebral ischemia, anoxia are had protective effect; Various atpase activity there is remarkable potentiation, and reduces LD content in the mouse brain tissue, alleviate cerebral tissue acidosis degree.
Compare with existing related techniques and application thereof, the present invention uses the natural material Fructus Hippophae extract Fructus Hippophae flavone of planting with traditional Chinese crude drug compatibility of using blood circulation promoting and blood stasis dispelling always, can both reach and reduce common prescription medical material use consumption, the purpose of corresponding its side effect of reduction, can bring into play mutually again and remedy, especially Fructus Hippophae flavone antithrombotic and resisting oxygen lack strengthen crude drug formula for treating effect, reach purposes such as prescription is reasonable, fast, the secondary toxic action of curative effect is little.
[specific embodiment]
Example 1
Get dry Fructus Hippophae 1000g and be ground into coarse powder, oil expression divides reflux, extract, four times with 85% ethanol 10L, and each 2～3 hours, to consider, merging filtrate reclaims ethanol, and is concentrated into dried.Oil expression (or with gasoline or defat with petroleum ether) again with ethanol 0.3L heating and refluxing extraction, is steamed and is removed ethanol, is concentrated into dried cream, uses the 0.1L water washing, and it is standby to be drying to obtain Fructus Hippophae extract.Press dry product and calculate, containing total flavones is that Fructus Hippophae flavone is with isorhamnetin (C
16H
12O
7) meter, should be 10.0%～14.0%.
Other gets Rhizoma Chuanxiong 500g, Radix Aucklandiae 125g, Radix Paeoniae Rubra 250g, Flos Carthami 125g, Fructus Crataegi 60g, the stripping and slicing of Rhizoma Cyperi 125g seven flavor medicine material, is ground into coarse powder.Decoct with water three times, each 1～1.5 hour, collecting decoction filtered; Filtrate low temperature (below 50 ℃) in the centrifugal thin-film evaporating dish concentrate or other reduced pressure under to be concentrated into relative density be 1.05～1.35 clear paste, add above-mentioned Fructus Hippophae extract (Fructus Hippophae flavone) 50g, and auxiliary materials and mixing such as lactose; Drying, granulation, tabletting are made 1000 promptly.
Example 2
Get formula ratio Rhizoma Chuanxiong 1000g, Radix Aucklandiae 250g, Radix Paeoniae Rubra 500g, Flos Carthami 250g, Fructus Crataegi 120g, Rhizoma Cyperi 250g puts in the extraction pot, adds decocting and carries three times, each 1.5～2 hours.Add 10 times of water gagings at every turn, soak after two hours, decocted 2 hours, filter.Merging filtrate, and be concentrated into about 1800ml, with 75% ethanol precipitate with ethanol, cold preservation 24 hours, filtering, filtrate is stand-by.Other gets above-mentioned Fructus Hippophae extract, and extracting in water three times filters.Filtrate merges, mixing.Be evaporated to about 1000ml, add sodium benzoate 2.5g and other dispersant adjuvant, stir evenly, cold preservation 48 hours with 0.8 μ m filtering with microporous membrane, adds water and makes into 1000ml, stir evenly, and fill, sterilization, injection gets product.
Claims (3)
1, a kind of Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease, comprise raw material and adjuvant, it is characterized in that: the proportioning of raw material prescription is formed for 1～6 part of (1) Fructus Hippophae extract (Fructus Hippophae flavone), 1～6 part of (2) Rhizoma Chuanxiong, 1～6 part of (3) Radix Salviae Miltiorrhizae, 1～6 part of (4) Radix Aucklandiae, 1～6 part of (5) Radix Paeoniae Rubra, 1～6 part on (6) Flos Carthami, 1～6 part of (7) Fructus Crataegi, 1～6 part of (8) Rhizoma Cyperi and adjuvant.
2, a kind of according to claim 1 Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease is characterized in that: this pharmaceutical preparation can be mixture, drop pill, granule, oral liquid, tablet, capsule or injection or other accommodable clinically dosage form.
3, as a kind of Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease as described in claim 1 and 2, it is characterized in that: include, but is not limited to following step of preparation process: (1) preparation of raw material: get Fructus Hippophae extract (Fructus Hippophae flavone) 25g, Rhizoma Chuanxiong 125g, Radix Salviae Miltiorrhizae 250g, Radix Aucklandiae 65g, Radix Paeoniae Rubra 125g, Flos Carthami 125g, Fructus Crataegi 35g, Rhizoma Cyperi 65g; (2) extract: abovely except that Fructus Hippophae extract (Fructus Hippophae flavone), seven distinguish the flavor of, add decocting three times, each 1.5～2 hours, collecting decoction, filtration; (3) concentrate: filtrate low temperature (below 50 ℃) in centrifugal-film evaporator concentrate or other decompression cryogenic conditions under to be concentrated into relative density be 1.05～1.35 clear paste; (4) batch mixing: clear paste adds above-mentioned Fructus Hippophae extract (Fructus Hippophae flavone), and auxiliary materials and mixing such as lactose; (5) drying and granulating: can adopt vacuum spray drying or batch (-type) fluid bed drying (6) preparation of granulating: tabletting or fill capsule: make in flakes or 1000 of capsules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510021869 CN1827138A (en) | 2005-10-17 | 2005-10-17 | Chinese medicine composition prescription for treating cardiovascular and cerebrovascular diseases and preparation technique thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510021869 CN1827138A (en) | 2005-10-17 | 2005-10-17 | Chinese medicine composition prescription for treating cardiovascular and cerebrovascular diseases and preparation technique thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1827138A true CN1827138A (en) | 2006-09-06 |
Family
ID=36945820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510021869 Pending CN1827138A (en) | 2005-10-17 | 2005-10-17 | Chinese medicine composition prescription for treating cardiovascular and cerebrovascular diseases and preparation technique thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1827138A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078377A (en) * | 2011-01-13 | 2011-06-01 | 铁顺良 | Medicament for treating cardio-cerebrovascular disease and gastropathy |
| CN104172359A (en) * | 2014-09-02 | 2014-12-03 | 王月水 | Vinegar beverage capable of preventing and treating cardiovascular and cerebrovascular diseases |
| CN105343365A (en) * | 2015-12-10 | 2016-02-24 | 韩雪海 | Traditional Chinese medicine fumigating and soaking combined liquid medicine for treating hyperlipidemia cerebral arteriosclerosis |
-
2005
- 2005-10-17 CN CN 200510021869 patent/CN1827138A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078377A (en) * | 2011-01-13 | 2011-06-01 | 铁顺良 | Medicament for treating cardio-cerebrovascular disease and gastropathy |
| CN104172359A (en) * | 2014-09-02 | 2014-12-03 | 王月水 | Vinegar beverage capable of preventing and treating cardiovascular and cerebrovascular diseases |
| CN105343365A (en) * | 2015-12-10 | 2016-02-24 | 韩雪海 | Traditional Chinese medicine fumigating and soaking combined liquid medicine for treating hyperlipidemia cerebral arteriosclerosis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101095736B (en) | Chinese traditional medicine composition for treating acute and chronic pharyngitis, tonsillitis and method of making the same | |
| CN102100874A (en) | Chinese patent drug for treating diabetes and preparation method thereof | |
| CN101940630B (en) | Traditional Chinese medicine composition for treating odontitis and preparation method thereof | |
| CN100540041C (en) | A kind of intelligence-enhancing and brain-enhancing preparation and its preparation method | |
| CN101780223B (en) | Traditional Chinese medicine with integral coordination function for treating ischemic cerebrovascular disease | |
| CN1657060A (en) | Shenkang freeze-dried powder injection for injection and its preparation technology | |
| CN111202827A (en) | Chinese medicine for preventing influenza, SARS, bird flu and new coronary pneumonia | |
| CN101095793A (en) | Chinese traditional medicine preparations liuweidihuang wine having functions of reinforcing body fluid and nourishing the blood and the kidney | |
| CN102657736B (en) | Medicament composition for treating rheumatoid arthritis and preparation method of medicament composition | |
| CN1654060A (en) | 'Kidney-Benefiting' glucose injection and its preparing process | |
| CN1173726C (en) | Medicine for curing malignant turnor and its preparation method | |
| CN102552509A (en) | Traditional Chinese medicine combination for reducing heat and relieving cough | |
| CN101683429A (en) | Animal Chinese medicine granular formulation for preventing and treating infectious bursal disease of fowl and preparation method thereof | |
| CN1827138A (en) | Chinese medicine composition prescription for treating cardiovascular and cerebrovascular diseases and preparation technique thereof | |
| CN101167951A (en) | Traditional Chinese medicinal composition for treating diabetes and its preparation method | |
| CN1180821C (en) | Medicine for treating cerebral thrombus and its prepn | |
| CN1039879C (en) | "Naoxuetong" oral liquor and its preparing method | |
| CN108186821B (en) | Traditional Chinese medicine composition for treating nervous headache and preparation method and application thereof | |
| CN101683452A (en) | Animal Chinese medicine oral liquid for preventing and treating infectious bursal disease of fowl and preparation method thereof | |
| CN105727089A (en) | Application of medicine composition containing folium artemisiae argyi to preparing medicine for treating irritable bowel syndrome | |
| CN1191086C (en) | Medicine for treating cold in summer and autumn | |
| CN1161131C (en) | Process for preparing antitussive mixture | |
| CN1194733C (en) | Medicine for treating hyperthyroidism and its prepn | |
| CN100486621C (en) | Chinese medicinal composition for treating hemilateral headache and its preparation method | |
| CN100475248C (en) | A medicine for treating metrorrhagia and preparation process thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |