CN1559523A - Naodesheng soft capsule and its preparation method - Google Patents
Naodesheng soft capsule and its preparation method Download PDFInfo
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- CN1559523A CN1559523A CNA2004100141580A CN200410014158A CN1559523A CN 1559523 A CN1559523 A CN 1559523A CN A2004100141580 A CNA2004100141580 A CN A2004100141580A CN 200410014158 A CN200410014158 A CN 200410014158A CN 1559523 A CN1559523 A CN 1559523A
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- rhizoma chuanxiong
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Abstract
A softcapsule 'Naodesheng' is prepared from notoginseng, Chuan-xiong rhizome, pueraria root, haw and safflower through respective extracting, removing impurities, concentrating, drying proportional mixing, adding plant oil and dissolving-suspending air and die pressing or dripping.
Description
Technical field
The present invention relates to a kind of consciousness-restoring and orifice-opening, dredging the meridian, blood circulation promoting and blood stasis dispelling, cure mainly soft capsule Naodesheng of cerebral arteriosclerosis, ischemia apoplexy and apoplexy sequela etc. and preparation method thereof.
Background technology
NAODESHENG PIAN and NAODESHENG ball record in " one one of Chinese pharmacopoeia version in 2000, be national essential drugs, form by Radix Notoginseng, Flos Carthami, Rhizoma Chuanxiong, Radix Puerariae and Fructus Crataegi five kinds of Chinese medicine, Radix Notoginseng in the side " can in its blood stasis of blood systemization " (" book on Chinese herbal medicine is looked for the truth "), Flos Carthami " kind tonneau passages through which vital energy circulates " (" medicine justice "), " controlling trismus and inability to speak, blood agglomeration " (Tang Materia Medica), two medicines share, promoting blood circulation to remove blood stasis, dredge the meridian passage is monarch drug; Rhizoma Chuanxiong " gas medicine in the blood ", blood-activating and qi-promoting reaches disease institute from the meridians priming, is ministerial drug; Radix Puerariae is sweet flat, gently clearly uply goes into brain with priming, the effect of principal drug assistance blood stasis dispelling; Share the Fructus Crataegi promoting blood circulation to remove blood stasis, be adjuvant.All medicine compatibilities are played the effect of blood circulation promoting and blood stasis dispelling, dredging the meridian QI and blood altogether.Modern pharmacological research proves: the arasaponin that Radix Notoginseng contains, can improve brain microcirculation to treating cerebral ischemia, and plasma viscosity is reduced; The Carthamus yellow that Flos Carthami is contained has the protection cerebral tissue, and the ischemia resisting anoxia also has the whole blood contrast viscosity of reduction, plasma viscosity, reduces effects such as packed cell volume; The ligustrazine that contains in the Rhizoma Chuanxiong can improve the cerebral cortex blood circulation, and Rhizoma Chuanxiong also can reduce whole blood contrast viscosity, plasma viscosity, packed cell volume etc.; And the flavone that extracts in the Radix Puerariae can increase brain and crown vascular flow amount.The NAODESHENG pharmacological research shows that also this product mainly contains expansion of cerebral vascular and coronary vasodilator, blood fat reducing, blood viscosity lowering, antithrombotic form, improve effects such as superoxide dismutase activity, antioxidation in the cerebral tissue.So the NAODESHENG preparation has significant curative effect at treatment cerebral arteriosclerosis, ischemia apoplexy and apoplexy sequela etc.
Traditional NAODESHENG preparation mostly is honeyed pill, tablet, capsule, granule, and honey pill agent is not easy to the patient and takes and accept, absorption difference in the body, and the crude drug powder directly is used as medicine, and easily pollutes, and poor stability is difficult to store.Tablet, capsule, granule both be unfavorable for control of microorganisms owing to also contain crude drug powder, had influenced the absorption of effective ingredient again.Also there is not in a kind of five tastes medical material active ingredient extract manufacture method and stay-in-grade NAODESHENG manufactured goods more completely at present.
Summary of the invention
The objective of the invention is to overcome the defective of above-mentioned prior art, provide a kind of and be convenient to store, be difficult for polluting, active ingredient is extracted and is removed impurity more fully and to greatest extent, is easy to absorption of human body, gives full play to soft capsule Naodesheng of curative effect of medication and preparation method thereof.
Chinese medicine is Radix Notoginseng, Rhizoma Chuanxiong, Radix Puerariae, Fructus Crataegi, Flos Carthami among the present invention, it is characterized in that each component adopts extract to be used as medicine: the dry extract that Rhizoma Chuanxiong dry extract and Radix Puerariae, Fructus Crataegi, Flos Carthami are made behind Radix Notoginseng dry extract, Rhizoma Chuanxiong volatile oil and the extraction volatile oil, the each component weight proportion is:
Radix Notoginseng, Rhizoma Chuanxiong, Radix Puerariae, Fructus Crataegi, Flos Carthami extract 50～500
Vegetable oil 0～500
Solubilising suspending agent 0～25.
The each component extract is: Radix Notoginseng with ethanol percolate extraction, the dry powder that concentrates, obtain after the drying; Rhizoma Chuanxiong extract earlier medicinal residues behind the volatile oil again water extract-alcohol precipitation, concentrate, dry powder that drying obtains; Radix Puerariae, Fructus Crataegi, Flos Carthami water extract-alcohol precipitation, the dry powder that concentrates, obtains after the drying; Be sprayed at the Rhizoma Chuanxiong volatile oil on the mixed composition.
Vegetable oil is a kind of or its mixture in soybean oil, Oleum Arachidis hypogaeae semen, Oleum Sesami or the Semen Maydis oil; The solubilising suspending agent is a kind of or mixture in aluminium stearate, stearyl alcohol and the Cera Flava.
The weight proportion of Chinese medicine of the five flavours of the present invention is:
Radix Notoginseng 78 Rhizoma Chuanxiongs 78 Radix Puerariaes 261
Fructus Crataegi 157 Flos Carthamis 91.
Preparation method of the present invention comprises the steps:
(1) Radix Notoginseng powder is broken into coarse powder, adds ethanol percolation, collect percolate, the percolate decompression recycling ethanol is condensed into the thick paste shape, and vacuum drying becomes dried cream;
(2) Radix Puerariae, Fructus Crataegi, Flos Carthami are decocted with water, filter, filtrate is condensed into clear paste, adds the ethanol precipitate with ethanol, and the supernatant decompression recycling ethanol is condensed into the thick paste shape, and vacuum drying becomes dried cream;
(3) Rhizoma Chuanxiong elder generation steam distillation is extracted volatile oil, filter, medicinal residues decoct with water, and filter, and merging filtrate is condensed into clear paste, adds the ethanol precipitate with ethanol, and the supernatant decompression recycling ethanol is condensed into the thick paste shape, and vacuum drying becomes dried cream;
(4) above-mentioned dried cream is mixed, pulverizes, sieves, spray into Rhizoma Chuanxiong volatile oil, add vegetable oil and solubilising suspending agent by proportioning, the ball milling porphyrize is made suspension;
(5) gelatin, glycerol, water are made glue in 1: 0.28: 1.3 ratio, more above-mentioned suspension and glue are placed the dropping-pill machine ball or make soft capsule with mold pressing.
Effect of the present invention
The present invention takes separately extraction, remove impurity, technology concentrated, dry, that soft capsule is made in mixing again that the active ingredient in the Chinese medicine of the five flavours is extracted and concentrated to greatest extent, remove impurity more completely, overcome in the common extraction manufacture method that the active ingredient loss is big, storage period shortcoming such as weak point, appearance poor, thereby be easy to absorption of human body, give full play to the curative effect of medicine.
Further specify content of the present invention below by embodiment, but do not mean that the present invention only limits to these
The scope of embodiment.
The specific embodiment
Embodiment 1
At first get all the Chinese medicine of the five flavours raw material ready by proportioning:
Radix Notoginseng 78g Rhizoma Chuanxiong 78g Radix Puerariae 261g
Fructus Crataegi 157g Flos Carthami 91g.
Production method is as follows:
Cut three and to be ground into coarse powder, add 10 times of amounts of 80% ethanol percolation, collect percolate, the percolate decompression recycling ethanol is condensed into the thick paste shape, and it is standby that vacuum drying becomes dried cream below 85 ℃; Second step added 10 times of amounts of water with Radix Puerariae, Fructus Crataegi, Flos Carthami and decocted 1 hour, filter, medicinal residues add 8 times of amounts of water again and decoct twice, each 1 hour, filter, three filtrate merging are condensed into the clear paste of relative density 1.10 (50 ℃), add ethanol precipitate with ethanol (alcohol precipitation concentration 70%), the supernatant decompression recycling ethanol is condensed into the thick paste shape, and it is standby that vacuum drying becomes dried cream below 85 ℃; The 3rd step added 10 times of water gaging vapor distillation methods of water earlier with Rhizoma Chuanxiong and extracts volatile oil, time is 4 hours, filters, and medicinal residues add 10 times of amounts of water, decocted 1 hour, filter, merging filtrate is condensed into the clear paste of relative density 1.10 (50 ℃), add ethanol precipitate with ethanol (alcohol precipitation concentration 70%), the supernatant decompression recycling ethanol is condensed into the thick paste shape, and it is standby that vacuum drying becomes dried cream below 85 ℃; The 4th step mixed above-mentioned dried cream, pulverize, sieve, and sprayed into Rhizoma Chuanxiong volatile oil, added soybean oil 150g then, Cera Flava 4g, and the ball milling porphyrize is made suspension; At last gelatin, glycerol, water are made glue in 1: 0.28: 1.3 ratio, place the dropping-pill machine ball to make soft capsule Naodesheng suspension and glue again.
Embodiment 2
Get extract 70g, Semen Maydis oil 120g, other are with embodiment 1.
Embodiment 3
Get extract 100g, Semen Maydis oil 150g, aluminium stearate 2g, Cera Flava 2g, other are with embodiment 1.
Embodiment 4
Get extract 80g, Semen Maydis oil 95g, Cera Flava 4g, other are with embodiment 1.
Embodiment 5
Get extract 200g, Semen Maydis oil 250g, aluminium stearate 2g, Cera Flava 4g, other are with embodiment 1.
Embodiment 6
At first get all the Chinese medicine of the five flavours raw material ready by proportioning:
Radix Notoginseng 78g Rhizoma Chuanxiong 78g Radix Puerariae 261g
Fructus Crataegi 157g Flos Carthami 91g.
Production method is as follows:
Cut three and to be ground into coarse powder, add 10 times of amounts of 80% ethanol percolation, collect percolate, the percolate decompression recycling ethanol is condensed into the thick paste shape, and it is standby that vacuum drying becomes dried cream below 85 ℃; Second step added 10 times of amounts of water with Radix Puerariae, Fructus Crataegi, Flos Carthami and decocted 1 hour, filter, medicinal residues add 8 times of amounts of water again and decoct twice, each 1 hour, filter, three filtrate merging are condensed into the clear paste of relative density 1.10 (50 ℃), add ethanol precipitate with ethanol (alcohol precipitation concentration 70%), the supernatant decompression recycling ethanol is condensed into the thick paste shape, and it is standby that vacuum drying becomes dried cream below 85 ℃; The 3rd step added 10 times of water gaging vapor distillation methods of water earlier with Rhizoma Chuanxiong and extracts volatile oil, time is 4 hours, filters, and medicinal residues add 10 times of amounts of water, decocted 1 hour, filter, merging filtrate is condensed into the clear paste of relative density 1.10 (50 ℃), add ethanol precipitate with ethanol (alcohol precipitation concentration 70%), the supernatant decompression recycling ethanol is condensed into the thick paste shape, and it is standby that vacuum drying becomes dried cream below 85 ℃; The 4th step mixed above-mentioned dried cream, pulverize, sieve, and sprayed into Rhizoma Chuanxiong volatile oil, and the ball milling porphyrize is made soft capsule Naodesheng with die pressing.
Embodiment 7
Get extract 400g, soybean oil 80g, other are with embodiment 6.
Claims (5)
1, a kind of soft capsule Naodesheng, Chinese medicine is Radix Notoginseng, Rhizoma Chuanxiong, Radix Puerariae, Fructus Crataegi, Flos Carthami, it is characterized in that each component adopts extract to be used as medicine: the dry extract that Rhizoma Chuanxiong dry extract and Radix Puerariae, Fructus Crataegi, Flos Carthami are made behind Radix Notoginseng dry extract, Rhizoma Chuanxiong volatile oil and the extraction volatile oil, the each component weight proportion is:
Radix Notoginseng, Rhizoma Chuanxiong, Radix Puerariae, Fructus Crataegi, Flos Carthami extract 50～500
Vegetable oil 0～500
Solubilising suspending agent 0～25.
2, soft capsule Naodesheng according to claim 1 is characterized in that the each component extract is: Radix Notoginseng with ethanol percolate extraction, the dry powder that concentrates, obtain after the drying; Rhizoma Chuanxiong extract earlier medicinal residues behind the volatile oil again water extract-alcohol precipitation, concentrate, dry powder that drying obtains; Radix Puerariae, Fructus Crataegi, Flos Carthami water extract-alcohol precipitation, the dry powder that concentrates, obtains after the drying; Be sprayed at the Rhizoma Chuanxiong volatile oil on the mixed composition.
3, soft capsule Naodesheng according to claim 1 is characterized in that vegetable oil is a kind of or its mixture in soybean oil, Oleum Arachidis hypogaeae semen, Oleum Sesami or the Semen Maydis oil; The solubilising suspending agent is a kind of or mixture in aluminium stearate, stearyl alcohol and the Cera Flava.
4, soft capsule Naodesheng according to claim 1 is characterized in that the weight proportion of Chinese medicine of the five flavours is:
Radix Notoginseng 78 Rhizoma Chuanxiongs 78 Radix Puerariaes 261
Fructus Crataegi 157 Flos Carthamis 91
5, the preparation method of soft capsule Naodesheng according to claim 1 is characterized in that this method comprises the steps:
(1) Radix Notoginseng powder is broken into coarse powder, adds ethanol percolation, collect percolate, the percolate decompression recycling ethanol is condensed into the thick paste shape, and vacuum drying becomes dried cream;
(2) Radix Puerariae, Fructus Crataegi, Flos Carthami are decocted with water, filter, filtrate is condensed into clear paste, adds the ethanol precipitate with ethanol, and the supernatant decompression recycling ethanol is condensed into the thick paste shape, and vacuum drying becomes dried cream;
(3) Rhizoma Chuanxiong elder generation steam distillation is extracted volatile oil, filter, medicinal residues decoct with water, and filter, and merging filtrate is condensed into clear paste, adds the ethanol precipitate with ethanol, and the supernatant decompression recycling ethanol is condensed into the thick paste shape, and vacuum drying becomes dried cream;
(4) above-mentioned dried cream is mixed, pulverizes, sieves, spray into Rhizoma Chuanxiong volatile oil, add vegetable oil and solubilising suspending agent by proportioning, the ball milling porphyrize is made suspension;
(5) gelatin, glycerol, water are made glue in 1: 0.28: 1.3 ratio, more above-mentioned suspension and glue are placed the dropping-pill machine ball or make soft capsule with die pressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100141580A CN1559523A (en) | 2004-02-23 | 2004-02-23 | Naodesheng soft capsule and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100141580A CN1559523A (en) | 2004-02-23 | 2004-02-23 | Naodesheng soft capsule and its preparation method |
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| Publication Number | Publication Date |
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| CN1559523A true CN1559523A (en) | 2005-01-05 |
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| CNA2004100141580A Pending CN1559523A (en) | 2004-02-23 | 2004-02-23 | Naodesheng soft capsule and its preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103931792A (en) * | 2014-03-21 | 2014-07-23 | 安徽省怀远县鑫泰粮油有限公司 | Cardiovascular and cerebrovascular disease preventing peanut oil and its preparation method |
| CN104305179A (en) * | 2014-10-09 | 2015-01-28 | 丁荣吾 | Broad-spectrum high-efficiency functional food with effects of calming heart, activating collaterals, reducing blood pressure and reducing blood fat and preparation method thereof |
| CN106626496A (en) * | 2017-02-27 | 2017-05-10 | 天津橘井科技有限公司 | Traditional Chinese medicine fine powder compression mold forming technique |
| CN108935848A (en) * | 2018-08-01 | 2018-12-07 | 上海应用技术大学 | A kind of bag tea and preparation method thereof containing dendrobium leaf with reduction postprandial blood sugar function |
| CN110731984A (en) * | 2018-07-18 | 2020-01-31 | 中国医学科学院药物研究所 | pharmaceutical composition, preparation method and application thereof in treating cerebral arterial thrombosis |
-
2004
- 2004-02-23 CN CNA2004100141580A patent/CN1559523A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103931792A (en) * | 2014-03-21 | 2014-07-23 | 安徽省怀远县鑫泰粮油有限公司 | Cardiovascular and cerebrovascular disease preventing peanut oil and its preparation method |
| CN104305179A (en) * | 2014-10-09 | 2015-01-28 | 丁荣吾 | Broad-spectrum high-efficiency functional food with effects of calming heart, activating collaterals, reducing blood pressure and reducing blood fat and preparation method thereof |
| CN106626496A (en) * | 2017-02-27 | 2017-05-10 | 天津橘井科技有限公司 | Traditional Chinese medicine fine powder compression mold forming technique |
| CN110731984A (en) * | 2018-07-18 | 2020-01-31 | 中国医学科学院药物研究所 | pharmaceutical composition, preparation method and application thereof in treating cerebral arterial thrombosis |
| CN108935848A (en) * | 2018-08-01 | 2018-12-07 | 上海应用技术大学 | A kind of bag tea and preparation method thereof containing dendrobium leaf with reduction postprandial blood sugar function |
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