CN100493535C - Compounding traditional Chinese medicine-Xueyaping for treating hypertension, and its preparation method - Google Patents
Compounding traditional Chinese medicine-Xueyaping for treating hypertension, and its preparation method Download PDFInfo
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Abstract
A Chinese medicine 'Xueyaping' in the form of nasal drops, oral liquid, spray, particle, tablet and capsule for treating hypertension, lowering cardiac rhythm, increasing blood flow in arteria coronaria and kidney, and improving heart function is prepared from 10 Chinese-medicinal materials including chrysanthemum flower, red peony root, cinnamon bark, Chuan-xiong rhizome, etc. Its preparing process is also disclosed.
Description
One, technical field
The present invention relates to a kind of compound Chinese medicinal preparation, specifically relate to a kind of mediodespidine compound Chinese medicinal preparation for the treatment of hypertension and preparation method thereof.
Two, background technology
The dosage form that the new Chinese medicine kind of treatment hypertension relates to has medicinal tea, bagged steeping drug, tablet, capsule, granule etc.As dogbane tea, Chinese hawthorn blood-pressure-reducing teabag, Chinese hawthorn blood-pressure-reducing sheet, SONGLING XUEMAIKANG JIAONANG, brain-benefiting blood pressure-reducing capsule, brain-benefiting blood pressure-reducing capsule, brain-benefiting blood pressure-reducing granule, day female hypertension pill, capsule for clearing liver and reducing blood pressure, Calculus Bovis hypertension pill, two summer hypertension pill, Kang Heng blood pressure lowering granule, FUFANG LUOBUMA PIAN, Zhenju Jiangya Tablet; wherein, most functions cure mainly and are used for suppressing the hyperactive liver and subsiding YANG.
The common feature of these Chinese medicines is compound preparations, and is oral, and onset is slow, and any hypertensive emergency is not prove effective.Given this, to the preventive and therapeutic effect that do not have of hypertension thunder bolt, senile hypertension, gestational hypertension levied there is no treatment report.
Three, summary of the invention
The object of the present invention is to provide a kind of mediodespidine compound Chinese medicinal preparation for the treatment of hypertension and preparation method thereof.
A kind of mediodespidine compound Chinese medicinal preparation is characterized in that by following materials of weight proportions medicine made:
Spica Prunellae 5～30g, Flos Chrysanthemi 5～25g, Flos Magnoliae 3～15g, Radix Paeoniae Rubra 5～20g, Cortex Moutan 5～20g, Cortex Cinnamomi 3～15g, Rhizoma Chuanxiong 5～25g, Radix Angelicae Sinensis 5～20g, Radix Aristolochiae 3～15g, Herba Menthae 5～20g.
The side separates:
The side is cold with the Spica Prunellae toil, goes into the liver and gall warp, the liver heat removing eliminating stagnation, and " the southern regions of the Yunnan Province book on Chinese herbal medicine " cloud: can " the row irritability to be opened stagnation of liver-QI for the liver-wind of dispelling, the network of passing through ", modern pharmacological research is thought the merit with diuresis and blood pressure lowering, so be monarch drug.Flos Chrysanthemi sweetness and bitterness is cool in nature, goes into the lung Liver Channel, " herbal classic " cloud " main all dizziness due to wind "; Hot cool a surname is saturating for Herba Menthae, and " Japan hanako materia medica " thinks the merit of the favourable blood vessels of this product, " detailed outline is picked up any lost article from the road " cloud " dispel the wind tomorrow, search irritability, control and have a dizzy spell ".Radix Aristolochiae: arduous temperature, depressed liver-energy dispersing and QI regulating.Above-mentioned all medicines share, wind and heat dispersing, and it is strongly fragrant that circulation of qi promoting is loose, and helps that Spica Prunellae is soothing the liver to loose strongly fragrant and be ministerial drug.Liver is a viscus of storing blood, pathogenic fire derived from stagnation of liver-QI, and the heat stagnation blood stasis, the bright cloudy blood that disappears, Gu Zuo is with removing heat from blood, the product of invigorating blood circulation.Radix Paeoniae Rubra removing heat from blood easing the affected liver; The Cortex Moutan purging liver-fire, cool the blood dissipate blood stasis; The hot temperature of Rhizoma Chuanxiong is gone into liver and gall warp, activating QI to alleviate the depression; Radix Angelicae Sinensis fragrance reaches thoroughly, helps the Radix Paeoniae Rubra nourshing blood and promoting blood circulation to hold concurrently with easing the affected liver, and the tonifying liver body is used with the system liver.The Cortex Cinnamomi suffering is warm and sweet, goes into the conscience lung meridian, main current blood vessels, exploitation fur, " book on Chinese herbal medicine is new again " cloud energy " warming middle-JIAO promoting the circulation of blood "; The hot temperature of Flos Magnoliae, sensible Eradicates wind.The two is harmonious, and the promoting the circulation of blood of having one's ideas straightened out is messenger drug altogether.All medicines are harmonious, the cool and usefulness of temperature, and giving consideration to both the incidental and fundamental, purging liver-fire and do not have the fraud that cold is held back, residence is lived in supporting, and nourishing blood to suppress the hyperactive liver has the merit of dissipating blood stasis concurrently; Invigorating middle warmer has row, tonify without causing stagnation, the row and do not consume healthy energy, circulation of qi promoting is soothing the liver, the eliminating stagnation dissipating depression of QI makes blood circulation depending on qi flow, liver department bar reaches, and all diseases oneself remove.
The prescription of mediodespidine compound Chinese medicinal preparation and preparation method, its preparation process is as follows:
Prescription: Spica Prunellae 5～30g, Flos Chrysanthemi 5～25g, Flos Magnoliae 3～15g, Radix Paeoniae Rubra 5～20g, Cortex Moutan 5～20g, Cortex Cinnamomi 3～15g, Rhizoma Chuanxiong 5～25g, Radix Angelicae Sinensis 5～20g, Radix Aristolochiae 3～15g, Herba Menthae 5～20g.
(1) get Flos Chrysanthemi, Flos Magnoliae, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Menthae way of distillation extraction volatile oil, place container, medicinal residues are standby;
(2) Cortex Moutan vapor distillation is collected distillate, and paeonol is collected in cold preservation, places container, and medicinal residues are standby;
(3) medicinal residues and Spica Prunellae, Radix Paeoniae Rubra, the Radix Aristolochiae with step (1), (2) merges, and decocts with water decocting liquid thin film concentration, cooling, add ethanol, cold preservation filters, and filtrate is through decompression recycling ethanol, the concentrated solution cooling adds ethanol, cold preservation again, filter, filtrate to there not being the alcohol flavor, adds water to 950ml through decompression recycling ethanol, cold preservation filters the filtrate heat treatment, cold preservation filters filtrate for later use;
(4) get the volatile oil of step (1) and the paeonol of step (2), gradation adds the solution of step (3), and adds the relevant auxiliary materials of an amount of different dosage form, makes nasal drop, oral liquid, spray, granule, tablet or capsule with conventional preparation method.
Decoct with water 2～3 times in the above-mentioned steps (3), each 1～2 hour, decocting liquid with thin film concentration to relative density 1.05 (65 ℃ heat survey), add ethanol and make and contain alcohol amount and reach 60%, add ethanol for the second time again and make and contain the alcohol amount and reach 80%, 95 ℃/30min of filtrate heat treatment, cold preservation filters filtrate for later use.
The key of having researched and proposed hypertensive etiology and pathogenesis of mediodespidine spray is a depression of liver-QI, obstruction of collaterals by blood stasis, the rule of treatment that proposes hypertension is a dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood circulation to remove obstruction in the collateral, each phase hypertension all there is the obvious treatment effect, special hypertensive patient is had significant therapeutic effect.
The nasal-cavity administration method is one of external treatment of Chinese medicine, is consistent with the principle of the treatment by oral administration of medicines of taking medicine, and " nose be the blood fortune of the whole body, and the nostril is the key of lung, leads on the gas in brain in face, and is descending in lung." (" skin infection pandect "), " pearl in red water " said: " its QI and blood all rises and walks the sky key in face for the twelve regular channels, 365 networks." nasal-cavity administration, but not only the abnormal smells from the patient of messenger drug followed row with each QI of channels and collaterals and fail the cloth whole body: but also get it and open the lung promoting the circulation of QI, stagnated fire reaches outward; lung qi is sent out, transferred along irritability to rise with row, and lung qi is respectful to fall and the gas pathogenic fire reducing is fallen; fire falls then that blood falls, and all diseases are from disappearing so blood falls with gas, the promptly so-called strong golden method of making wood.Modern study finds that the effect of nasal-cavity administration mainly realizes by following approach: the first, blood capillary is abundant, intensive under the nasal membrane, the hole is big, absorbs the rear section and enters jugular vein, and part enters the intracranial cavernous sinus, helps the absorption of medicine.The second, drug molecule enters trachea, bronchus, lung tissue with breathing (full respiratory tract has 80～90m approximately
2Absorption area, have powerful absorbability), in lung, enter pulmonary circulation, heart with gas exchange, arrive each histoorgan performance therapeutical effect of whole body.Three, brain is imported in the impulsion that is produced by vegetative nerve tip and olfactory receptor cell rapidly into, after big mesencephalic centre analyzing and processing, sends corresponding feedback impulsion, regulates neuro function.The argumentation that the mechanism of action that this and motherland's medical science cue are treated is summed up as nose, lung, brain fits like a glove.
The mediodespidine nasal drop through zoopery and clinical practice all can obviously bring high blood pressure down, decreased heart rate, coronary blood flow increasing and renal blood flow, reduction myocardial oxygen consumption, improve cardiac function and blood vessel wall metamorphosis, and can suppress spontaneous activity in mice etc., these effects are favourable to hypertension.Acute toxicity and long term toxicity test all do not have obvious toxic-side effects.
Mediodespidine nasal drop, spray, oral liquid, granule, tablet and capsule show hypertension merging coronary heart disease through clinical practice, hypertensive heart disease, except that relief of symptoms, can obviously increase blood supply of cardiac muscle, can reduce the variability of blood pressure, safeguard the circadian rhythm of blood pressure, microcirculation improvement increases the heart, cerebral blood supply.
Four, the specific embodiment
Embodiment 1 " the crude drug weight proportion and the preparation technology thereof of mediodespidine nasal drop, oral liquid, spray:
1, prescription: Spica Prunellae 15g, Flos Chrysanthemi 15g, Flos Magnoliae 5g, Radix Paeoniae Rubra 10g, Cortex Moutan 10g, Cortex Cinnamomi 5g, Rhizoma Chuanxiong 10g, Radix Angelicae Sinensis 10g, Radix Aristolochiae 5g, Herba Menthae 10g, make 40ml altogether.
2, method for making: above ten flavors, get Flos Chrysanthemi, Flos Magnoliae, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Herba Menthae way of distillation is extracted volatile oil, Cortex Moutan vapor distillation, collect distillate, paeonol is collected in cold preservation, above-mentioned medicinal residues and all the other each medical materials are merged, decoct with water 2 times, each 1h, collecting decoction, thin film concentration is to relative density 1.05 (65 ℃ of heat are surveyed), cooling, add ethanol and make and contain alcohol amount and reach 60%, cold preservation filters, filtrate is through decompression recycling ethanol, and the concentrated solution cooling adds ethanol again and makes and contain the alcohol amount and reach 80%, cold preservation filters, and filtrate is not distinguished the flavor of to there being alcohol through decompression recycling ethanol, add water to 950ml, cold preservation filters, the filtrate heat treatment (95 ℃/30min), cold preservation filters filtrate for later use.Get above-mentioned volatile oil and paeonol, add an amount of propylene glycol, tween 80 grinds well, gradation adds above-mentioned solution, adds water to 1000ml, regulates pH value 5～6, aseptic filtration, packing, promptly.
Embodiment 2 " the crude drug weight proportion and the preparation technology thereof of mediodespidine granule, tablet, capsule:
1, prescription: Spica Prunellae 15g, Flos Chrysanthemi 15g, Flos Magnoliae 5g, Radix Paeoniae Rubra 10g, Cortex Moutan 10g, Cortex Cinnamomi 5g, Rhizoma Chuanxiong 10g, Radix Angelicae Sinensis 10g, Radix Aristolochiae 5g, Herba Menthae 10g.
2, method for making: above ten flavors, get Flos Chrysanthemi, Flos Magnoliae, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Herba Menthae way of distillation is extracted volatile oil, Cortex Moutan vapor distillation, collect distillate, paeonol is collected in cold preservation, above-mentioned medicinal residues and all the other each medical materials are merged, decoct with water 2 times, each 1h, collecting decoction, thin film concentration is to relative density 1.05 (65 ℃ of heat are surveyed), cooling, add ethanol and make and contain alcohol amount and reach 60%, cold preservation filters, filtrate is through decompression recycling ethanol, and the concentrated solution cooling adds ethanol again and makes and contain the alcohol amount and reach 80%, cold preservation filters, and filtrate is not distinguished the flavor of to there being alcohol through decompression recycling ethanol, add water to 950ml, cold preservation filters, the filtrate heat treatment (95 ℃/30min), cold preservation, filter, filtrate is condensed into thick paste, adds the appropriate amount of auxiliary materials dextrin, granulate, dry, granulate, get above-mentioned volatile oil and paeonol, add an amount of ethanol, spraying adds on the above-mentioned dried granule, airtight, packing promptly gets granule; Or capsule charge or further add suitable diluents and make soft capsule; Or further add adjuvant compacting commonly used (comprising buccal tablet, dispersible tablet, effervescent tablet etc.) in flakes.
The pharmacological action of embodiment 3 mediodespidine nasal drop:
Animal experiment study: mediodespidine nasal drop 0.5g/kg, 1.5g/kg all can obviously reduce the blood pressure and the heart rate of spontaneous hypertensive rat and two kidneys, one folder type Hypertensive Rats, with model group comparing difference remarkable (P＜0.05, P＜0.01); Mediodespidine nasal drop 0.5g/kg, 1.5g/kg all can obviously increase the body weight of spontaneous hypertensive rat and two kidneys, one folder type Hypertensive Rats, alleviate its heart weight/body weight (VW/BW), chamber, a left side heavy (LV), right ventricle heavy (RV), weight/right ventricle, chamber, a left side heavy (LV/RV), right kidney heavy (RK), left kidney weigh/right kidney heavy (LK/RK), kidney weight/body weight (KW/BW) increases left kidney heavy (LK); Can reduce the activity of blood plasma PRA and the content of minimizing AgII, reduce left ventricle and aortic arch pipe thickness, with model group comparing difference remarkable (P＜0.05, P＜0.01); Mediodespidine nasal drop 0.2g/kg, press (SP, DP, MP), heart rate, cardiac output, stroke volume, cardiac index, left ventricular pressure, left chamber diastasis pressure, the maximum climbing speed of left indoor pressure, stroke work index, total oxygen consumption index 0.6g/kg can obviously reduce Sanguis Canitis, increase coronary flow, with normal saline comparing difference remarkable (P＜0.05, P＜0.01), but total peripheral resistance, t-dp/dtmax there is not obvious influence; Mediodespidine nasal drop 0.3g/kg, 0.9g/kg all can obviously increase the renal artery blood flow amount, with normal saline comparing difference remarkable (P＜0.05, P＜0.01); Mediodespidine nasal drop 1.0g/kg, 3.0g/kg all can make the movable number of times of mice obviously reduce, with normal saline group comparing difference remarkable (P＜0.05).Illustrate the mediodespidine nasal drop to laboratory animal can obviously bring high blood pressure down, decreased heart rate, coronary blood flow increasing and renal blood flow, reduction myocardial oxygen consumption, improve cardiac function and blood vessel wall metamorphosis, and can suppress spontaneous activity in mice etc., these effects are favourable to hypertension.Acute toxicity and long term toxicity test all do not have obvious toxic-side effects.
The clinical application effect of embodiment 4 mediodespidine nasal drop
The mediodespidine nasal drop is used for clinical each phase hypertensive patient 70 example, can obviously bring high blood pressure down, and especially can reduce diastolic pressure reposefully, is better than FUFANG JIANGYA PIAN group 30 example and compound Herba Apocyni veneti (Folium Apocyni Veneti) group 30 examples; Can improve symptom rapidly, the syndrome integration is descended, its curative effect is better than FUFANG JIANGYA PIAN and compound Herba Apocyni veneti (Folium Apocyni Veneti); The energy decreased heart rate reduces myocardial oxygen consumption; Can obviously increase blood supply of cardiac muscle, electrocardiogram ischemic ST and T ripple are improved; Can keep the circadian rhythm of blood pressure; Can increase hypertensive patient's heart rate variability, regulate vegetative nerve function, microcirculation improvement increases the heart, cerebral blood supply; Can obviously slow down rapid atrial fibrillation patient's Ventricular Rate increases its blood supply of cardiac muscle; Companion's left ventricular hypertrophy person has the possibility that the left ventricle structure is reinvented; Can safe blood pressure lowering to hypertension patients, the generation of the prevention heart, cerebrovascular thunder bolt; Try out 8 examples, can obviously bring high blood pressure down, patient's retinal edema is alleviated, remove the optical fundus arteriolospasm, reduced the utilization of dehydrant, increase puerpera's blood supply of cardiac muscle, anemia of pregnant woman and fetus are had protective effect in the pregnancy induced hypertension syndrome patient.Hepatic and renal function and glycolipid metabolism are had no adverse effects.
Embodiment 5: the clinical practice of mediodespidine granule is material as a result:
The mediodespidine granule is used for clinical each phase hypertensive patient 80 example, can obviously reduce patient's blood pressure, especially can reduce patient's diastolic pressure reposefully, is better than FUFANG JIANGYA PIAN group 40 example and compound Herba Apocyni veneti (Folium Apocyni Veneti) group 40 examples (P＜0.01); Can improve patient's symptom rapidly, the syndrome scoring is descended, its curative effect obviously is better than FUFANG JIANGYA PIAN and compound Herba Apocyni veneti (Folium Apocyni Veneti) (P＜0.01): effective percentage is 92%: energy decreased heart rate (P＜0.01), reduce myocardial oxygen consumption: hypertension is merged coronary heart disease, hypertensive heart disease, except that relief of symptoms, can obviously increase blood supply of cardiac muscle, electrocardiogram ischemic ST and T ripple are improved; Can reduce the variability of blood pressure, keep the circadian rhythm of blood pressure: can increase hypertensive patient's heart rate variability, regulate vegetative nerve function, microcirculation improvement increases the heart, cerebral blood supply.
Embodiment 6: the clinical practice result of mediodespidine oral liquid:
The mediodespidine oral liquid is used for clinical each phase hypertensive patient 40 example, can obviously reduce patient's blood pressure, especially can reduce patient's diastolic pressure reposefully, is better than FUFANG JIANGYA PIAN group 20 example and compound Herba Apocyni veneti (Folium Apocyni Veneti) group 20 examples (P＜0.01); Can safe blood pressure lowering to hypertension patients, the generation of the prevention heart, cerebrovascular thunder bolt.
Embodiment 7:
The mediodespidine soft capsule is used for clinical each phase hypertensive patient 42 example, can obviously reduce patient's blood pressure, especially can reduce patient's diastolic pressure reposefully, is better than FUFANG JIANGYA PIAN group 20 example and compound Herba Apocyni veneti (Folium Apocyni Veneti) group 20 examples (P＜0.01); Can improve patient's symptom rapidly, the syndrome scoring is descended, its curative effect obviously is better than FUFANG JIANGYA PIAN and compound Herba Apocyni veneti (Folium Apocyni Veneti) (P＜0.01): effective percentage is 91%: energy decreased heart rate (P＜0.01), reduce myocardial oxygen consumption.
Embodiment 8:
The blood pressure plain film is used for clinical each phase hypertensive patient 60 example, can obviously reduce patient's blood pressure, especially can reduce patient's diastolic pressure reposefully, be better than FUFANG JIANGYA PIAN group 30 example and compound Herba Apocyni veneti (Folium Apocyni Veneti) group 30 examples (P＜0.01): hypertension is merged coronary heart disease, hypertensive heart disease, except that relief of symptoms, can obviously increase blood supply of cardiac muscle, electrocardiogram ischemic ST and T ripple are improved; Can reduce the variability of blood pressure, keep the circadian rhythm of blood pressure: can increase hypertensive patient's heart rate variability, regulate vegetative nerve function, microcirculation improvement, increase the heart, cerebral blood supply: can safe blood pressure lowering to hypertension patients, the generation of the prevention heart, cerebrovascular thunder bolt.
Embodiment 9:
The mediodespidine buccal tablet is used for clinical each phase hypertensive patient 70 example, can obviously reduce patient's blood pressure, especially can reduce patient's diastolic pressure reposefully; Can improve patient's symptom rapidly, the syndrome scoring is descended: hypertension be merged coronary heart disease, hypertensive heart disease, except that relief of symptoms, can obviously increase blood supply of cardiac muscle, electrocardiogram ischemic ST and T ripple are improved; Can reduce the variability of blood pressure, keep the circadian rhythm of blood pressure: can increase hypertensive patient's heart rate variability, regulate vegetative nerve function, microcirculation improvement, increase the heart, cerebral blood supply: the rapid atrial fibrillation patient's that can obviously slow down Ventricular Rate increases its blood supply of cardiac muscle.
Embodiment 10:
The mediodespidine spray is used for hypertensive emergency patient 20 examples, and the energy rapid depressurization alleviates cerebral edema, improves clinical symptoms, and does not reduce the blood supply of heart and brain; Be used for each phase patients with hypertension, clinical efficacy is better than FUFANG JIANGYA PIAN group and compound Herba Apocyni veneti (Folium Apocyni Veneti) group, improves symptom rapidly, and the syndrome integration is descended, and decreased heart rate reduces myocardial oxygen consumption; Obviously increase blood supply of cardiac muscle, electrocardiogram ischemic ST and T ripple are improved; Keep the circadian rhythm of blood pressure; Increase hypertensive patient's heart rate variability, regulate vegetative nerve function, microcirculation improvement increases the heart, cerebral blood supply; Obviously slow down rapid atrial fibrillation patient's Ventricular Rate increases its blood supply of cardiac muscle; Companion's left ventricular hypertrophy person has the possibility that the left ventricle structure is reinvented; Can safe blood pressure lowering to hypertension patients, the generation of the prevention heart, cerebrovascular thunder bolt.
Claims (3)
1. mediodespidine compound Chinese medicinal preparation is characterized in that by following materials of weight proportions medicine made:
Spica Prunellae 5～30g, Flos Chrysanthemi 5～25g, Flos Magnoliae 3～15g, Radix Paeoniae Rubra 5～20g, Cortex Moutan 5～20g, Cortex Cinnamomi 3～15g, Rhizoma Chuanxiong 5～25g, Radix Angelicae Sinensis 5～20g, Radix Aristolochiae 3～15g, Herba Menthae 5～20g.
2. method for preparing claim 1 mediodespidine compound Chinese medicinal preparation, its preparation process is as follows:
(1) get Flos Chrysanthemi, Flos Magnoliae, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Menthae way of distillation extraction volatile oil, place container, medicinal residues are standby;
(2) Cortex Moutan vapor distillation is collected distillate, and paeonol is collected in cold preservation, places container, and medicinal residues are standby;
(3) medicinal residues and Spica Prunellae, Radix Paeoniae Rubra, the Radix Aristolochiae with step (1), (2) merges, and decocts with water decocting liquid thin film concentration, cooling, add ethanol, cold preservation filters, and filtrate is through decompression recycling ethanol, the concentrated solution cooling adds ethanol, cold preservation again, filter, filtrate to there not being the alcohol flavor, adds water to 950ml through decompression recycling ethanol, cold preservation filters the filtrate heat treatment, cold preservation filters filtrate for later use;
(4) get the volatile oil of step (1) and the paeonol of step (2), gradation adds the solution of step (3), and adds the relevant auxiliary materials of an amount of different dosage form, makes nasal drop, oral liquid, spray, granule, tablet or capsule with conventional preparation method.
3. preparation method according to claim 2, it is characterized in that decocting with water 2～3 times in the step (3), each 1～2 hour, decocting liquid is surveyed with thin film concentration to 1.05,65 ℃ of relative densities heat, adds ethanol and makes and contain the alcohol amount and reach 60%, adding ethanol again makes and contains alcohol amount and reach 80%, 95 ℃/30min of filtrate heat treatment filters, and obtains clear filtrate.
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Non-Patent Citations (2)
| Title |
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| 治痛药对琐谈. 孙龙川.江西中医药，第18卷第6期. 1987 |
| 治痛药对琐谈. 孙龙川.江西中医药，第18卷第6期. 1987 * |
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