CN102772748B - Traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis. The traditional Chinese medicine preparation comprises the following components in parts by weight: 10-20 parts of radix bupleuri, 10-20 parts of cape jasmine, 10-20 parts of fructus forsythiae, 10-20 parts of radix pseudostellariae, 10-20 parts of prepared rehmannia root, 10-20 parts of cassia twig, 10-20 parts of fructus ligustri lucidi, 10-20 parts of oldenlandia diffusa, 10-20 parts of radix ophiopogonis, 10-20 parts of the root of red-rooted salvia, 10-20 parts of carthamus tinctorius, 10-20 parts of radix paeoniae alba, 10-20 parts of pseudo-ginseng, 10-20 parts of astragalus mongholicus, 10-20 parts of prepared fleece flower root, 10-20 parts of poria cocos, 10-20 parts of vegetable sponge, 10-20 parts of ligusticum wallichii, 10-20 parts of curcuma zedoary, 10-20 parts of scutellaria baicalensis, 10-20 parts of albizia julibrissin, 10-20 parts of silkworm larva, 10-20 parts of angelica sinensis, and 10-20 parts of platycladi seeds. The traditional Chinese medicine preparation disclosed by the invention is capable of rapidly in-flowing blood, directly achieving myocardium and rapidly increasing myocardial contraction force and has the main functions of detoxifying, removing stasis, clearing heat, opening the inhibited lung-energy and clearing away the heart-fire; in addition, the functions of tonifying qi and calming the mind and the functions of soothing the liver and reducing heat are combined, the functions of rapidly relieving patient conditions and saving lives of patients are achieved.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly a kind ofly treating Chinese medicine preparation of caused by hepatic stagnation qi stagnation viral myocarditis and preparation method thereof.
Background technology
Medically research can find, cause myocarditic reason to be divided into: virus, antibacterial, fungus or parasite, external condition is as physics in addition, and chemical factor etc. all can cause myocarditis.Myocarditis refers to myocardium limitation or diffuse acute or chronic inflammatory conditions, can be divided into infectious and non-infectious two large classes.Infectious myocarditis can caused by virus, antibacterial, spirillum, rickettsia, mycete, protozoon, anthelmintic, and non-infectious myocarditis then comprises allergy or allergy myocarditis, as the myocarditis etc. of rheumatism and chemical factors or drug-induced.Myocarditic symptoms of varying severity, coincident with severity degree of condition is not etc.The lighter can no conscious sympton; Severe patient can show as sudden death, severe arrhythmia, cardiogenic shock or heart failure, causes acute stage dead; Also various arrhythmia, pericarditis or acute myocardial infarction etc. can be shown as.Caused by hepatic stagnation qi stagnation viral myocarditis, general disease sees severe palpitation, does during cardiopalmus, vexed uncomfortable in chest, insomnia and dreamful sleep, bitter taste in the mouth and dry throat, and constipation is dizzy, sensation of oppression over the chest with shortness of breath, spiritlessness and weakness, spontaneous perspiration or night sweat, red tip of the tongue, thin fur, stringy and rolling pulse or short.High liver fire the most easily causes vexed gas hot-tempered, bitter taste in the mouth and dry throat, constipation, so it is main that the removing toxic substances of clinical needs clears away heart-fire; QI invigorating mind calming and soothing the liver expelling the heat-evil are share, and reach rapid mitigate the disease.
Viral myocarditis is the class myocarditis that the most common, number of the infected is maximum clinically, there is popularity, comparatively before 10 years, sickness rate rises more than 10 times now, become the modal cardiomyopathy of China, multiple be born in viral infection in crowd popular when, about have the patient of 5% to cause viral myocarditis at viral infection epizootic modeling.In recent years, the understanding of viral myocarditis is constantly deepened.Myocarditic virus can be caused a lot, and as Coxsackie virus, adenovirus, influenza virus etc., the myocarditis wherein especially caused with change of coxsackie b virus is the most common, because cardiac muscle is responsive especially to this virus performance, myocardium has special affinity to this virus.After patient infection Coxsackie virus, about have 5% involve heart.All can there is focal necrosis in heart myocardial cell everywhere; With inflammatory cell infiltration in necrosis region, mainly mononuclear cell, also has neutrophilic granulocyte sometimes, and inflammatory cell reaction is sometimes not obvious.Necrosis region finally replaces for fibrosis, and Children's virus myocarditis clinical manifestation is comparatively grown up seriously.Viral myocarditis is so far without specific treatment, and modern medicine is all generally adopt to suit the medicine to the illness and supporting treatment.Be mainly and alleviate heart burden, take a good rest and nutrition; Carry out symptomatic treatment for the symptom such as heart failure, arrhythmia occurred simultaneously, and cardiac nutrition, myocardial metabolism of improving, sometimes apply adrenocortical hormone.After increased in acute viral myocarditis, usually need convalescent treatment for a long time, half a year at least, the even 1-2 had, or longer a period of time.
At present, modern medicine there is no effective Therapeutic Method to viral myocarditis.The clinical manifestation of viral myocarditis is different, and myocarditic symptom may come across symptom phase or the convalescent period of protopathy, and as the symptom phase in protopathy occurs, its performance can be covered by protopathy.Most of patients has the symptoms such as heating, systemic pain, pharyngalgia, diarrhoea at premorbid, and reflection systemic viral infects, but also has some patients protopathy mild symptoms and remarkable, and must carefully be noted the side of questioning closely, myocarditis symptom is then more remarkable.Patients with myocarditis often tells uncomfortable in chest, pareordia dull pain, cardiopalmus, weak, nauseating, dizzy.In the myocarditis diagnosed clinically, about 90% to be chief complaint with arrhythmia or head is shown in symptom, and wherein small number of patients can occur to faint or Adams Stokes syndrome therefrom.Only a few patient plays development after being ill and rapidly, occurs heart failure or cardiogenic shock.About there is the patient of 60% ~ 88% about morbidity the last fortnight, had the pioneer such as sense or diarrhoea in heating, pharyngalgia, general pain etc. current, viral myocarditis has become the commonly encountered diseases of medical science medical field, hazardness is very big, but there is no the Chinese medicine preparation of drug administration by injection safely and effectively so far; Do not have effective experience side clinically, flavour of a drug are more, and all adopt decoct oral, also do not have Chinese medicine injection dosage form, slow to drug absorption for the more not only body of peroral dosage form, and use also inconvenient.Directly have influence on therapeutic effect and the scope of application of the type medicine.
During this disease of clinical treatment, the measures such as the anti-bolt medicine of main employing, nitrate esters medicine and bypass surgery treatment.Viral myocarditis then more adopts western medicine antibiotics, and such as oral ribavirin, intravenous injection inosine, aspara, vitamin C etc., its general effect is not obvious, and cure rate is low, and toxic and side effects is large.Western medical treatment is still based on chemotherapy, treatment cycle is long, and side effect is large, and uncertain therapeutic efficacy is cut, and not easily adhere to, traditional Chinese medical science traditional therapy does not have the Chinese medicine of special treatment to come out yet, and do not have effective experience side clinically, flavour of a drug are more, and all adopt decoct oral, also there is no Chinese medicine injection dosage form, slow to drug absorption for the more not only body of peroral dosage form, and use also inconvenient.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine preparation for the treatment of viral myocarditis and preparation method thereof is provided, remain in many deficiencies for the medicine for the treatment of viral myocarditis at present, if western medical treatment is still based on chemotherapy, treatment cycle is long, side effect is large, uncertain therapeutic efficacy is cut, and not easily adheres to, traditional Chinese medical science traditional therapy does not have the Chinese medicine of special treatment to come out yet, there is no effective experience side clinically, can only add and subtract with disease according to each doctor's clinical experience; And flavour of a drug are more, mostly adopt decoct oral, also do not have Chinese medicine injection dosage form, use also inconvenient, drug effect is slow.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of caused by hepatic stagnation qi stagnation viral myocarditis, disease sees severe palpitation, do during cardiopalmus, vexed uncomfortable in chest, insomnia and dreamful sleep, bitter taste in the mouth and dry throat, constipation is dizzy, sensation of oppression over the chest with shortness of breath, spiritlessness and weakness, spontaneous perspiration or night sweat, red tip of the tongue, thin fur, stringy and rolling pulse or short, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: Radix Bupleuri 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Fructus Forsythiae 10 ~ 20 parts, Radix Pseudostellariae 10 ~ 20 parts, Radix Rehmanniae Preparata 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Herba Hedyotidis Diffusae 10 ~ 20 parts, Radix Ophiopogonis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, the Radix Paeoniae Alba 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, 10 ~ 20 parts, Poria, Retinervus Luffae Fructus 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Bombyx Batryticatus 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Semen Platycladi 10 ~ 20 parts.
The Chinese medicine preparation of described treatment caused by hepatic stagnation qi stagnation viral myocarditis, in described Chinese medicine preparation, the ratio of weight and number of various crude drug can also be: Radix Bupleuri 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Fructus Forsythiae 10 ~ 15 parts, Radix Pseudostellariae 10 ~ 15 parts, Radix Rehmanniae Preparata 10 ~ 15 parts, Ramulus Cinnamomi 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Herba Hedyotidis Diffusae 10 ~ 15 parts, Radix Ophiopogonis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, the Radix Paeoniae Alba 10 ~ 15 parts, Radix Notoginseng 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, 10 ~ 20 parts, Poria, Retinervus Luffae Fructus 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Bombyx Batryticatus 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Semen Platycladi 10 ~ 20 parts.
The Chinese medicine preparation of described treatment caused by hepatic stagnation qi stagnation viral myocarditis, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug also can be: Radix Bupleuri 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Fructus Forsythiae 10 ~ 20 parts, Radix Pseudostellariae 10 ~ 20 parts, Radix Rehmanniae Preparata 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Herba Hedyotidis Diffusae 10 ~ 20 parts, Radix Ophiopogonis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, the Radix Paeoniae Alba 10 ~ 20 parts, Radix Notoginseng 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, 10 ~ 15 parts, Poria, Retinervus Luffae Fructus 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Rhizoma Curcumae 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, Bombyx Batryticatus 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Semen Platycladi 10 ~ 15 parts.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of caused by hepatic stagnation qi stagnation viral myocarditis, and to be the preparation process of honey refining pill be described pharmaceutical dosage form: a, first Radix Pseudostellariae, Radix Salviae Miltiorrhizae and Radix Astragali ethanol are refined;
B, again the medicinal residues refined and all the other crude drug are put into multi-function extractor extracting in water;
C, then by extracted twice thing combination drying powdering, add Mel and be twisted into pill.
In described step a, Radix Pseudostellariae, Radix Salviae Miltiorrhizae and the Radix Astragali can be got and add in the ethanol of 5-10 times amount, extract 2 times; Heating extraction 1-2 hour, is concentrated into mass shape.
In described step b, the medicinal residues refined and all the other crude drug can be put into multi-function extractor, add in the water of 5-10 times amount, extract 2 times; Heating extraction 1-2 hour, is concentrated into mass shape.
For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method for the treatment of the Chinese medicine preparation of caused by hepatic stagnation qi stagnation viral myocarditis, and the dosage form of described medicine is that the preparation process of drop pill comprises:
A, first by Bombyx Batryticatus, Rhizoma Curcumae, Rhizoma Chuanxiong and Radix Notoginseng extract; Adsorb for subsequent use;
B, again all the other components are put into water and extract; Sedimentation and filtration, leaves standstill;
C, get above-mentioned two kinds of standing drops and enter in dimethicone to cool to obtain drop pill.
In described step a, can according to described component ratio of weight and number by Bombyx Batryticatus, Rhizoma Curcumae, Rhizoma Chuanxiong and Radix Notoginseng add the water of its weight sum 5-7 times amount, put into multi-function extractor, keep air pressure to decoct 2 hours at 0.04-0.06mPa, extract its water soluble ingredient; Extracting liquid filtering 100 mesh sieve; Ethanol elution after filtrate is refined with adsorbent resin; Eluent is evaporated to density 1.33-1.35, and wherein input air pressure is 0.04-0.06mPa, and vacuum is-0.076 ~-0.088mPa, stand for standby use;
In described step b, again all the other components can be added the water of its weight sum 5-7 times amount; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours; Filter extracting solution crosses 100 mesh sieves; Vacuum concentrated filtrate, to crude drug amount 1: 1W/V; Concentrated solution adds alcohol settling; Alcohol settling liquid 100 mesh sieves filter; Use sephadex chromatography is refined, with ethanol elution; Eluent is concentrated into density 1.33-1.35, leaves standstill.
The present invention treats the dosage form of the Chinese medicine preparation of caused by hepatic stagnation qi stagnation viral myocarditis, and its dosage form can be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, drop pill or extractum.
Compared with prior art, the extract that the inventive method obtains is convenient to the preparation of solid preparation.When extract of the present invention is prepared into solid preparation, usual extracting solution spray-driedly must become extract powder, then granulates, thus reduces supplementary product consumption in preparation, reduces clinical taking dose.If the sample liquid after water extract-alcohol precipitation is carried out spraying dry, very easily sticky wall, be difficult to obtain dried powder, loss is very big, even if obtain powder, because hygroscopicity is very strong, is also difficult to make granule, makes troubles to the preparation of solid preparation.And the present invention is comparatively thorough owing to removing impurity through ultracentrifugal medicinal liquid, after concentrated, spraying dry, can obtain dry loose powdered, after granulating, yield rate is high, can be suitable for large-scale production.
Pill dripping machine technical parameter is as follows: drip irrigation temperature keeps 85-95 DEG C, and condensed fluid liquid paraffin temperature is lower than 8 DEG C, and water dropper internal diameter is 1.6mm, and water dropper external diameter is 2.5mm, and water dropper distance liquid paraffin surface distance is 15cm; Centrifugal, rotating speed 800-1100rpm, after 15 minutes, except deparaffnize.For quick acting, drop pill of the present invention be made into can in Sublingual the piller of rapid solution absorption, it can enter blood fast, and through cardiac muscle, strengthens myocardial contraction rapidly, and increase coronary artery blood flow, protecting myocardial cell, improves cardiac function.
The technique effect that the present invention is useful is: the myocarditic medicine of application selected Chinese medicinal material preparation treatment, the medicine made can not only improve myocardial metabolism, cardiac nutrition, cardioprotection cell, improve the resistance against diseases of cardiac muscle, and energy direct killing virus, alleviate the damage of virus to cardiac muscle, play antiviral and the integrally-regulated action effect combined; Alleviate the side effect that Western medicine prolonged application produces human body, become and desirable be used for the treatment of myocarditic medicine, the present invention contains a large amount of active component, and raw material is cheap, and preparation method is simple, can apply in clinical practice in a large number.The present invention can enter blood fast, and through cardiac muscle, strengthens myocardial contraction rapidly, and eliminating toxic substances to remove stasis, reducing heat and dispersing lung-QI, it is main that removing toxic substances clears away heart-fire; Supplementing QI and nourishing YIN and blood circulation promoting and blood stasis dispelling share, and QI invigorating mind calming and soothing the liver expelling the heat-evil are share, and can reduce phlegm diuretic; Reach rapid mitigate the disease, save the effect of sufferer life.And raw material is cheap, preparation method is simple, can apply in clinical practice in a large number.
Detailed description of the invention
Viral myocarditis is clinical more common cardiac disorder, is mainly in teenager and middle age.Deficiency of YIN high liver fire type myocarditis violates by evil poison is outer, and inside give up caused by the heart, liver-fire type of phlegm-heat attacking the heart type, does when disease sees cardiopalmus, vexed uncomfortable in chest, insomnia and dreamful sleep, bitter taste in the mouth and dry throat, constipation, yellowish or reddish urine, red tongue, yellow and greasy fur, stringy and rolling pulse; Belong to categories such as motherland's medical science " cardiopalmus " " palpitation with a distress feeling " " thoracic obstruction " " asthenia " more.The heart occupies in the heart, controlling blood and vessel, house mind.Be arteries and veins at body, arteries and veins is the house of blood.In battalion's row arteries and veins, defensive QI circulating outside the vessel, battalion defends root in middle Jiao, can in cardiopulmonary.Exopathogen is attacked, and chief criminal battalion defends, and it is evil stagnant and do not fall apart, and stays and does not go, or goes and not to the greatest extent, can follow sering, inside give up in the heart.Again " qi being the governor of blood, blood being the material foundation of QI ", the deficiency of vital energy is then agitated unable, and blood deficiency then heart mistake is moistened foster, all can form primary disease.
Viral myocarditis relates to the category such as " cardiopalmus ", " palpitation with a distress feeling ", " thoracic obstruction " of the traditional Chinese medical science, Chinese medicine viral myocarditis has unique advantage, according to confirming the Couple herbs of this disease and experimentation for many years, to hold concurrently with removing toxic substances as method with supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, treat with syndrome of deficiency of both qi and yin or to hold the viral myocarditis effect that the stasis of blood is main clinical manifestation under the arm better.
Sui's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases " is said: " wind palpitation with fear person, empty by body, deficiency of heart-QI, the mansion of the heart is taken advantage of by ailment said due to cold or exposure, or frightened melancholy is compeled, and makes us the deficiency of vital energy, and also by ailment said due to cold or exposure, ailment said due to cold or exposure is fought in the heart, then frightened from peace, shy endlessly then startle indefinite." " warm pathogen tend to attack the upper orifices, attacking the lung first, the pathogen attacking the pericardium adversely." therefore at the beginning of primary disease, the disease of the criminal's of showing lung attacked by common evil poison, then gives up in the heart in pathogen, and occurs that the motive is disturbed, qi-blood disharmony, the cloudy impaired all cards of gas of the heart.Primary disease mostly is cardiopulmonary in early days with sick.Sick to middle and late stage then main manifestations be the QIYINLIANGXU of the heart or the syndrome of QI and blood retardance.Also have because of the difference such as ferritic or inducement, show as gas YANG deficiency; Accumulate in phlegm-damp; Stagnant heat in the liver and gall, deficiency of heart-QI; Or deficiency of heart-YANG and kidney-YANG, the disease persons such as the heart attacked by pathogenic water.The sick position of primary disease is at the heart in a word, and holds concurrently and he is dirty.Pathogenesis belongs to empty or deficiency in origin and excess in superficiality, and mostly is simulataneous insufficiency and excessive syndrome.The common Q-T interval prolongation of electrocardiogram, T popin is smooth or be inverted, various arrhythmia as frequent premature beat, I, II Aminophyline, sinus tachycardia etc.For the treatment of primary disease, the initial stage, it was main that removing toxic substances clears away heart-fire with reducing heat and dispersing lung-QI; Middle and late stage is then biased respectively with supplementing QI and nourishing YIN according to the prosperity and decline of negative and positive of qi and blood, or supplementing QI and nourishing YIN and blood circulation promoting and blood stasis dispelling share, or QI invigorating mind calming and soothing the liver expelling the heat-evil are share, or helps the Yangfu(jing-River point,GB 38) of heart kidney with the methods such as diuretic of reducing phlegm.In the myocarditis course of disease, it is particularly important that Gu protects cloudy liquid, its sick heresy just having pyretic toxicity, there is the wound of cloudy liquid in disease, if with its deficiency of vital energy, impose the tonics such as the Radix Ginseng of large benefit, unsuitable in institute, if help it with the sweet cool Radix Panacis Quinquefolii of hardship, the Radix Astragali, first except deficiency of YIN heat, second reinforcing both QI and YIN, more helps the tonify deficiency of Radix Notoginseng, three restrain Radix Notoginseng, Bombyx Batryticatus property of medicine partial heat fraud, four medicine help promoting blood circulation to remove blood stasis, detoxify eliminating evil, its reinforcing both QI and YIN, merit that is smooth and blood vessels is existing, and the disease of " cardiopalmus ", " thoracic obstruction ", " palpitation with a distress feeling " must be controlled.
Radix Angelicae Sinensis invigorating the spleen and replenishing QI in side, spermatogenesis nourishes blood; Radix Astragali tonifying Qi and lifting yang, diuretic detumescent; Flos Carthami, Radix Salviae Miltiorrhizae and pseudo-ginseng blood-circulation-invigovating blood stasis dispelling; Rhizoma Curcumae promoting the circulation of QI the chest stuffiness relieving; The obvious coronary dilating of ginsenoside's tool, heart tonifying, reinforcement myocardial contraction, increase cardiac output, reduction myocardial oxygen consumption, reduction blood viscosity and peripheral vascular resistance effect, can reduce and eliminate oxygen-derived free radicals simultaneously, thus protection cardiac muscle is from ischemic injuries, invigorating the heart and spleen.All medicines share, and play that spleen reinforcing is nourished heart, the merit of promoting the circulation of QI to induce diuresis, blood circulation promoting and blood stasis dispelling altogether.Pharmacological research shows, the Radix Astragali has positive inotropic action, containing glucuronic acid, choline etc., can expand peripheral blood vessel, reduce blood pressure, and strengthens myocardial contractility, improves cardiac output, can suppress the acid of platelet di-phosphate ester simultaneously, improve microcirculation; Radix Angelicae Sinensis, Flos Carthami, Radix Salviae Miltiorrhizae can decreased heart rate, increase coronary flow, resist myocardial ischemia, and strengthen myocardial contraction; Radix Pseudostellariae can arrhythmia, reduces heart rate, significantly reduces arterial pressure peak value; Rhizoma Chuanxiong, the calm diuresis of energy Radix Ophiopogonis, blood vessel dilating, improves coronary circulation; Radix Bupleuri, the Radix Paeoniae Alba is soothing the liver nourishes blood heat clearing away; Radix Polygoni Multiflori Preparata, Ramulus Cinnamomi improves vitality of human body, tonifies Qi of the kidney; Herba Hedyotidis Diffusae solution dispelling toxins and dredging collaterals; Semen Platycladi, Flos Albiziae clear away heart-fire relieving restlessness, tranquilizing by nourishing the heart; Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Radix Salviae Miltiorrhizae are the product of activating blood circulation and dissipating phlegm, to reach the effect of blood circulation promoting and blood stasis dispelling, regulating qi and dredging collateral.But the longer normal simulataneous insufficiency and excessive of the general medical history of thoracic obstruction patient is for suffering from, so-called empty, the not virtual loss of exogenous QI, blood, yin, yang; Real be often that the stagnation of QI, expectorant are turbid, cold coagulation, therefore clinically on essential drugs, need add and subtract, treat flexibly with card.Bombyx Batryticatus, activating blood circulation to dissipate blood stasis and dredge the collateral in side; The Radix Astragali, replenishing qi and promoting blood flow, invigorating yangqi, to strengthen the merit of promoting blood circulation to remove obstruction in the collateral; Fructus Ligustri Lucidi QI invigorating and body resistance strengthening, strengthens resistance.Effect that all medicines share and play promoting blood circulation to remove obstruction in the collateral altogether, QI invigorating is activated yang, giving consideration to both the incidental and fundamental.Modern pharmacological research confirms, Radix Paeoniae Alba energy anticoagulant and thrombosis, improve microcirculation, increases coronary blood flow; The extract of the Radix Astragali has cardiotonic, can improve heart stroke and cardiac index, and Retinervus Luffae Fructus detoxifies, and has blood vessel dilating, blood pressure lowering simultaneously, improves the effects such as microcirculation; Fructus Gardeniae has blood vessel dilating, excited heart, strengthens the effect of coronary blood flow and myocardial contraction.
The Radix Astragali, can invigorating QI to consolidate the body surface resistance based on tonify deficiency, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Cave in for insufficiency of vital energy and blood, skin infection, difficulty in discharging of pus or burst for a long time and do not hold back person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, Chinese medicine astragalus sweet in the mouth, and tepor returns lung spleen channel; Can ascending YANG and invigorating QI, and " pearl sac " " the sweet Wen Chunyang of the Radix Astragali, it is with having five: mend all empty not enough, one also; Benefit vigour, two also; Strong taste, three also; Go flesh heat, four also; To invigorate blood circulation hemopoietic,, five also ".Modern pharmacological research finds: the Radix Astragali and effective ingredient astragaloside thereof and α-tyrosine have blood vessel dilating, reduces Peripheral resistance, lightening heart load thus reduce myocardial oxygen consumption.The Radix Astragali can also improve the ability that myocardial cell anti-hypoxia " again oxygen supply " damages; alleviate the degree of injury of myocardial cell, maintain myocardial cell and to beat function, improve myocardial cell energy metabolism Cell protection ultrastructure; improve SOD in cell active, strengthen scavenging activated oxygen ability.Modern study finds: astragalin has positive inotropic action, there is dose-effect relationship, and has nothing to do with calcium ion concentration in Radix Astragali crude drug; And confirming that astragalin IV is its effective ingredient, it can make cAMP in myocardial cell raise, and activate the protein kinase of dependency ATP, make calciphorin phosphorylation, flow of calcium ions increases; In cell, cAMP raises simultaneously, promotes the release of sarcoplasmic reticulum calcium ion, thus myocardial cell Excitation-contraction Rhizoma Nelumbinis connection is strengthened.The Radix Astragali includes and multiple antibiotic effective ingredient, and the immunologic function of energy enhancing body, therefore can also be used for the generation preventing some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five ZANG-organs, controls stringy pulse spontaneous perspiration, rush down YIN-fire, remove lung-heat, lossless, sends out, and has antiperspirant then to stop." be the good medicine promoting resistance and defence disease.
Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Its chemical composition of Radix Salviae Miltiorrhizae is mainly divided into 2 classes: one is fat-soluble TANSHINONES, and one is water solublity danshensu etc.No matter be clinical or the most scholar of experimentation has affirmed that Radix Salviae Miltiorrhizae has coronary artery dilator, improve myocardium anti-anoxia ability, expansion peripheral blood vessel, improve microcirculation, regulate reparation and the regeneration of tissue, anticoagulant activates fibrinolytic, enhancing immunity, effect such as antibacterial grade.Especially it when core function badness, can improve myocardial contraction when not affecting oxygen consumption, decreased heart rate, and cardiac function is obviously improved, and blood flow can be made to accelerate, and capillary bed is open to be increased.
Flos Carthami is warm in nature, acrid in the mouth.Cure mainly latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converge with speech ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or blood is tired of bruise, and coma in silence; Or lochia robs the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth does not fall, dead fetus in the uterus, be all just before giving birth all cards, non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood room, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is amassed, or skin infection sufferings and swollenly burst uneasy, and be the card of all disharmony between QI and blood, non-Flos Carthami can not be adjusted." medicineization justice ": Flos Carthami, kind tonneau passages through which vital energy circulates, is gas medicine in blood, can rushes down and can mend, respectively having wonderful justice.If multiplex three, four money, then too pungent temperature, makes blood wander away.With Lignum Sappan removing blood stasis blood, conjunction Cortex Cinnamomi is stimulated the menstrual flow and closes, and assistant is returned, Chinese herbaceous peony controls all over or breast abdomen pricking caused by the stagnation of QI and blood, and this its row is led and invigorates blood circulation also.If use seven, eight points less, with dispersing liver-energy, to help the sea of blood, void of enriching blood greatly, this its adjust smooth and and blood also; If only with two, three points, enter the heart to join painstaking effort, dismiss heart channel pathogenic fire, make blood be in harmonious proportion, this its nourishing and hemopoietic are also; The justice of component number, meagre.Modern experimental shows that Flos Carthami has obvious effect to cardiovascular system: 1. suppress key role: Flos Carthami decoct low dose can make Bufo siccus isolated heart and rabbit heart in vivo slightly excited, make heart beating strong, amplitude strengthens; Heavy dose then has inhibitory action to heart, makes decreased heart rate, and myocardial contraction weakens, and cardiac output reduces.2. the experimentation of pair coronary flow shows: crude extract from carthamus tinctorius L. with water and Flos Carthami water soluble mixt-Carthamus yellow have the effect increasing coronary flow and cardiac muscle nutritional blood flow; The coronary artery dilating of Flos Carthami ethanol extraction and the effect increasing coronary flow then not obvious or without impact.3. the experimentation of pair expeirmental myocardial ischemia and myocardial infarction shows: cause on the animal model of expeirmental myocardial ischemia or myocardial infarction rabbit, rat, dog etc., Flos Carthami and preparation thereof all have antagonism in various degree.Flos Carthami can make the rat because pituitrin causes or Rabbits With Acute Myocardial Ischemia have obvious protective effect; Repeated Brief can be made to block coronary flow causes the degree of anesthetized dog acute myocardial ischemia obviously to alleviate; range shorter; decreased heart rate; and protect the edge in acute myocardial infarction district; district and reduce infarction size and reduce the amplitude that marginal zone ECG ST section raises, thus improve the supply-demand relationship of ischemic myocardium oxygen.Flos Carthami is because being improved the hemodynamics of myocardial ischemia reperfusion injury thus reaching the effect that protection cardiac muscle improves function containing safflower yellow.Safflower yellow is significantly increased the effect that coronary artery blood flow improves blood supply of cardiac muscle.In addition, safflower yellow has obvious inhibitory action to endogenous and extrinsic coagulation, can significant prolongation prothrombin time and clotting time, to all too many levels of coagulation process as platelet adhesion reaction, and thrombosis and fibrin is crosslinked etc. inhibitory action.
The sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock.Rare Chinese medicine, raw with can hemostasia and dissipation blood stasis, reducing swelling and alleviating pain, there is good hemostasia effect, significant hemopoietic function; Can tighten and improve Coronary microcirculation, Radix Notoginseng is used as medicine with a long history, acts on the peculiar treasured be considered as by ancient Chinese medicine doctor in medicine, therefore has the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) "." taste is micro-sweet and bitter, quite like the taste of Radix Ginseng for Radix Notoginseng." " all canes flutter trauma, and the dripping person of blood stasis, chew namely stopping of rotten net for catching birds or fish immediately, namely bruise person dissipate.If during by cane, first take one, two money, then the blood not centre of punch, should take it after cane especially, puerperal, clothes were also good.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of cloudy blood system of fainting, therefore all disorders of blood can be controlled "." book on Chinese herbal medicine is looked for the truth " is recorded: " Radix Notoginseng, common people only know function hemostasis and pain-relieving.Hardly realize that pain aches work because of blood stasis, because applying loose, blood stops blood.The bitter temperature of Radix Notoginseng abnormal smells from the patient, can in its blood stasis of blood systemization." Radix Notoginseng can increase coronary flow, decreased heart rate, reduces myocardial oxygen consumption, increases myocardium oxygen-resistant ability, improve microcirculation, removes the effect of smooth muscle spasm.
Radix Paeoniae Alba nourishing the liver is invigorated blood circulation.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Radix Paeoniae Rubra can purify the blood a point excess-heat, and dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between is for use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, can purify the blood a point excess-heat, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for blood system excess-heat, be good at promoting blood circulation to remove blood stasis.
Property Radix Ophiopogonis is sweet, mildly bitter flavor, is slightly cold.GUIXIN, lung, stomach warp.Function with cure mainly YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Control dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, quenches one's thirst, and calentura Tianjin is hindered, dry mouth and throat, constipation.This product is sweet cold clear and rich, the heat of the kind lung that clears away heart-fire and yin nourishing relieving restlessness, doublely can moisturize clear and rich gastrointestinal and quenching the thirst.There is On Antagonizing Experimental Arrhythmia, increase the effect of coronary flow.
Rhizoma Chuanxiong enters liver, spleen, three burnt three warps.Function cures mainly activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." detailed outline " carries: " dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine removes vascular smooth muscle (aortic article) spasm (epinephrine, potassium chloride cause).Can also coronary vasodilator be expanded, increase coronary flow.The myocardial ischemia-anoxemia that antagonism pituitrin causes.Alleviate the myocardial infarction lesion degree that ligation arteria coronaria causes.
Rhizoma Curcumae is pungent, bitter, temperature.Return liver, spleen channel.Removing blood stasis promoting the circulation of QI to relieve pain: this product effect is similar to Rhizoma Sparganii, but warm concerted effort is comparatively large, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.Long-pending eliminating stagnation: this product energy circulation of qi promoting removing food stagnancy pain relieving, for eating accumulation, breast abdominal distention is vexed has a pain.Removing blood stasis, women's amenorrhea, or the lump in the abdomen addiction block of phlegm-damp congestion condensation.Promoting the circulation of QI to relieve pain: be suitable for drinking and eating irregularly, the card of gastral cavity abdomen overflow pain.Suitable compatibility, deficient syndrome, the case of a physically strong patient running a high fever.
Retinervus Luffae Fructus: have dredge the meridian passage, effect of removing toxic substances and promoting subsidence of swelling.Cure mainly pain in chest and hypochondrium; Rheumatic arthralgia, passages through which vital energy circulates contracture, galactostasis, lung gesture is coughed, carbuncle future sore, his carbuncle." book on Chinese herbal medicine is just read ": Retinervus Luffae Fructus, enters meridians, separates pathogenic heat.Evanescence of heat then wind goes, and in network, the unlikely knot of body fluid is combined into expectorant, becomes all diseases of toxic swelling, therefore cloud removing toxic substances ear.
Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.Hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Radix Angelicae Sinensis: its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Fructus Ligustri Lucidi sweet in the mouth, hardship, cool in nature.Can Liver and kidney be taken a tonic or nourishing food to build up one's health, improving eyesight.Containing oleanolic acid, mannitol, glucose, Palmic acid, glyceric acid.There is enhancing immunologic function, raise peripheral leukocytes, strengthen reticuloendothelial system phagocytic activity, strengthen the effect of cellular immunization and humoral immunization; Have heart tonifying, diuresis and protect the liver, cough-relieving, cathartic, the effect such as antibacterial, anticancer.Purposes: for the hepatic and renal YIN deficiency, soreness of waist tinnitus, early whitening of beard and hair; Unseeing, poor vision; Fever due to yin deficiency.Fructus Ligustri Lucidi, sweet-bitter flavor, cool in nature, return Liver and kidney warp, there is nourishing the liver and kidney, merit that tonifying YIN nourishes blood.Modern medicine study proves, Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fatty wet goods, has heart tonifying, diuresis and hepatoprotective effect, the leukopenia quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, escherichia coli.
Herba Hedyotidis Diffusae Herba Hedyotidis Diffusae is again Herba Hedyotidis Diffusae, two leaves, Herba Commelinae Bengalensis, Chinese Lobelia.Mildly bitter flavor, sweet, cold.Enter stomach, large intestine, small intestine meridian, clearing up internal heat by using drugs of bitter in taste and cold in nature detoxifies, and sweet cold eliminating damp-heat, has stronger removing toxicity for eliminating carbuncles effect to carbuncle, pharyngalgia, snakebite etc.Be generally used for treatment sore, laryngopharynx swelling and pain, abdominalgia with intestinal abscess, venom, also for the puckery pain of pyretic stranguria, dysuria.The good medicine of damp eliminating of drawing out pus by applying a plaster to the affected part.
Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.But deficiency and coldness essence is sliding or collapse of QI person avoids clothes.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.
The flat sweet in the mouth of Semen Platycladi, the heart, kidney, large intestine channel.Effect of tool tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Control the diseases such as palpitation with fear, insomnia, seminal emission, night sweat, constipation, energy tranquilizing by nourishing the heart, loosening bowel to relieve constipation.For restlessness of asrhenia type and insomnia, severe palpitation, dryness of the intestine makes the secret disease that Dengs." medicineization justice ": Semen Platycladi, the saturating heart of fragrance, body profit grows blood.Same Poria cum Radix Pini, Semen Ziziphi Spinosae, the Radix Rehmanniae, Radix Ophiopogonis, be product clear in turbid, cure mainly mind void timid, palpitation with fear severe palpitation, color is wan and sallow, skin pruritus due to dryness, and the merit of the blood that all nourishes heart also.Get again abnormal smells from the patient all dense, return kidney in turbid, same to Radix Rehmanniae Preparata, Carapax et Plastrum Testudinis, Fructus Lycii, Radix Achyranthis Bidentatae, be packing bone marrow, cure mainly damage of kidney-YIN, back severe disease, sufficient knee joint is weak, and night sweat due to yin deficiency, the power that all nourishing kidney is dry also.Sweet in the mouth also can delay liver, the deficiency of tonifying liver gallbladder, extremely reliable, but the flat power of property delay, should be multiplex be wonderful.
Fructus Gardeniae is bitter, cold.GUIXIN, lung, tri-jiao channel.For calentura heating, vexed not rather wait disease.Fructus Gardeniae is kind can expel the heat-evil and relieving restlessness in pathogenic fire purging.At the edema caused by disorder of QI disease initial stage of fever caused by exogenous pathogenic factors, see have heating, the disease such as uncomfortable in chest, vexed, available Fructus Gardeniae coordinates Semen Sojae Preparatum, expels the heat-evil, relieving restlessness resolving depression with expelling pathogenic factors from the exterior.See the diseases such as high heat agitation, unconsciousness and delirium as belonged to all excess-heat fire diseases, available this product joins the pathogenic fire purgings such as Cortex Phellodendri and clear pathogen is warm.
Flos Albiziae contains Herba Albiziae glycoside, tannin, resolving stagnation for tranquilization, appetizing of regulating the flow of vital energy, activating collaterals to relieve pain, for irritability, melancholy insomnia.Control pent-up uncomfortable in chest, insomnia, forgetful, acute conjunctivitis, can settling five organs, and will, improving healthy complexion, have keep fit preferably, calm, the effect of calming the nerves, improve looks, be also treat neurasthenic good merchantable brand.Also have clearing away summer-heat, face-beautifying and spot-removing such as to relieve the effect of alcohol at the effect." herbal warp " is said: " Flos Albiziae energy settling five organs, and will, improving healthy complexion." especially to anemia of pregnant woman, have keep fit preferably, calm, the effect of calming the nerves, improve looks, be also treat neurasthenic good merchantable brand.
Radix Bupleuri is bitter, is slightly cold.Return liver, gallbladder meridian.Function with cure mainly evacuation and bring down a fever, soothing liver-QI, yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.Soothing the liver good medicine of fostering the spirit of nobility.
Ramulus Cinnamomi acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.1. antibacterial action: Ramulus Cinnamomi ethanol extract can suppress escherichia coli, bacillus subtilis and staphylococcus aureus in vitro, valid density is 25mg/ml or following; Also inhibitory action (flat board dig a hole method) 2. antivirus action is had: with the primary adhesion tissue culture of human embryo kidney (HEK), Ramulus Cinnamomi decoct (1: 20) has inhibitory action to the section 68-l strain of A type capital, influenza Asia and Orphan virus (ECHO11) to Staphylococcus albus, dysentery bacterium, Typhoid and paratyphoid first bacillus, streptococcus pneumoniae, aerobacteria, Bacillus proteus, anthrax bacillus, Salmonella enteritidis, vibrio cholera etc.On Embryo Gallus domesticus, infected by influenza has inhibitory action, better with 70% alcohol preserved material effect.
Radix Pseudostellariae has invigorating qi and benefiting blood, promotes the production of body fluid, the effect of tonifying the spleen and stomach.Be suitable for children's's summer heat of a specified duration do not move back, the disease of the weakness such as diet is depressed, the deficiency of the lung, cough, cardiopalmus and children's weak unable, spontaneous perspiration, night sweat, mouth equality disease after being ill.For deficiency of the lung cough caused by dryness and cardiopalmus sleeplessness, the deficiency-heat hyperhidrosis of deficiency of vital energy Tianjin wound.Can supplementing QI for promoting the production of body fluid.Control deficiency of vital energy xeropulmonary cough, join Radix Glehniae, Radix Ophiopogonis etc., control the cardiopalmus sleeplessness of deficiency of both QI and YIN, hyperhidrosis, complex acid Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis etc.But the power that its QI invigorating tonifying YIN promotes the production of body fluid, is all weaker than Radix Panacis Quinquefolii.. " book on Chinese herbal medicine is new again ": control the deficiency of vital energy dryness of the lung, spleen reinforcing soil, consumer edema, reduces phlegm and quenches the thirst.
Fructus Forsythiae is bitter, is slightly cold.Return lung, the heart, small intestine meridian.Function is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.Fructus Forsythiae medicinal effects mainly fruit.Its shell, " sticking up " namely in " a kind of reed mentioned in ancient books sticks up detoxifying pills ".Containing forsythol, coumarin, oleanolic acid, Saponin, Citrin etc.There is the effects such as heat clearing away, removing toxic substances, eliminating stagnation evacuation of pus.Cure mainly warm, skin infection, scrofula, erysipelas, class's rash, influenza, be decocted in water for oral dose with fruit, or add in prescription.Be usually used in anemopyretic cold.Nature,taste and action: Chinese medicine bitter in the mouth, cold nature.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.Mongolian medicine bitter in the mouth, cool in nature.Clearly " association's day ", antidiarrheal.Cure mainly: Chinese medicine controls calentura from the beginning of, anemopyretic cold, heating is vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, pyretic stranguria.Mongolian medicine is harnessed the Yellow River subcutaneous ulcer, intestinal twinge, and " association's day " is sick, intestinal heat.Sheng Nong's herbal classic ": main cold and heat, Mus flaccidity, scrofula, carbuncle, malignant boil, goiter, stagnation of pathogenic heat, diseases due to noxious agents produced by various parasites.
Bombyx Batryticatus expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Control apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble sore throat, scrofula tuberculosis.Wind skin ulcer urticaria, erysipelas, mastitis." herbal classic ": main pediatric epilepsy scared night cry, goes three worms, Mie Hei über, and the cloudy infections of man is sick." not Lu ": woman's metrorrhagia is in vain red, puerperal remaining pain, all skin ulcer cicatrixs of going out.
Radix Rehmanniae Preparata, Chinese medicine name, has another name called Radix Rehmanniae Preparata.For scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa(Gdertn) Iibosch.ex Fisch.et Mey.) tuber form through Processing methods.Usually with wine, Fructus Amomi, Pericarpium Citri Reticulatae for adjuvant is through repeatedly steaming solarization, to inside and outside darkish complexion glossy, quality softness is sticky.Section use, or parch to black is used.After the process of preparing Chinese medicine, the property of medicine turns tepor by being slightly cold, and tonification strengthens, " herbal classic is met former ": " Radix Rehmanniae Preparata, false firepower steams and shines, and it is sweet for turning a hardship, is the yang aspect of yin, therefore vigour in energy the kidney invigorating." generation research, the Dihuang polysaccharide contained by Radix Rehmanniae Preparata has obvious immune antitumor activity, also have significant heart tonifying, diuresis, protect the liver, blood sugar lowering, anti-proliferate, exudation, antiinflammatory, antifungal, the effect such as anti-radiation.
The manufacturing process of the present invention's honey refining pill is: first add in the ethanol of 5-10 times amount by Radix Pseudostellariae 1000g, Radix Salviae Miltiorrhizae 1000g and Radix Astragali 1000g, extract 2 times; Heating extraction 1-2 hour, is concentrated into mass shape; Again by the medicinal residues that refined and all the other crude drug Radix Bupleuri 1000g, Fructus Gardeniae 1000g, Fructus Forsythiae 1000g, Radix Rehmanniae Preparata 1000g; Ramulus Cinnamomi 1000g, Fructus Ligustri Lucidi 1000g, Herba Hedyotidis Diffusae 1000g, Radix Ophiopogonis 1000g; Flos Carthami 1000g, Radix Paeoniae Alba 1000g, Radix Notoginseng 1000g, Radix Polygoni Multiflori Preparata 1000g; Poria 1000g, Retinervus Luffae Fructus 1000g, Rhizoma Chuanxiong 1000g; Rhizoma Curcumae 1000g, Radix Scutellariae 1000g, Flos Albiziae 1000g; Bombyx Batryticatus 1000g, Radix Angelicae Sinensis 1000g, Semen Platycladi 1000g; Put into multi-function extractor, add in the water of 5-10 times amount, extract 2 times; Heating extraction 1-2 hour, is concentrated into mass shape, after two kinds of mass Hybrid Heating are dried to fine powder, call in Mel and makes honey refining pill.
Capsule preparation method thereof of the present invention is: get Radix Pseudostellariae 1000g, Radix Salviae Miltiorrhizae 1000g, Radix Astragali 1000g, Radix Bupleuri 1000g, Fructus Gardeniae 1000g; Fructus Forsythiae 1000g, Radix Rehmanniae Preparata 1000g, Ramulus Cinnamomi 1000g, Fructus Ligustri Lucidi 1000g; Herba Hedyotidis Diffusae 1000g, Radix Ophiopogonis 1000g, Flos Carthami 1000g, Radix Paeoniae Alba 1000g; Radix Notoginseng 1000g, Radix Polygoni Multiflori Preparata 1000g, Poria 1200g, Retinervus Luffae Fructus 1000g; Rhizoma Chuanxiong 1200g, Rhizoma Curcumae 1000g, Radix Scutellariae 1000g, Flos Albiziae 1200g; Bombyx Batryticatus 1000g, Radix Angelicae Sinensis 1000g, Semen Platycladi 1000g; Add the water soaking 1-2 hour of 5-10 times amount, extract 2 times; Heating extraction 1-2 hour, is concentrated into extractum shape, becomes component 1; Again medicinal residues are added 60-90% soak with ethanol 1-2 hour, extract twice, each 0.5-1 hour, merge extractive liquid, filters, concentrated, 80-160 order filter, 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.38 extractum, heating and refluxing extraction 2 times, each 30 minutes ~ 45 minutes, extracts active ingredient, extracted twice liquid is merged and is settled into extractum shape, as component 2; Adding ethanol thickening filtration is extractum shape, is component 2; Be pulverized and mixed by component 2 extractum, add dextrin in right amount, put into hothouse drying, hot stream temperature is 80 DEG C-100 DEG C, obtains raw material medicated powder, incapsulates patent medicine.
The preparation method of Tablets: add Radix Pseudostellariae 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 1500g, Radix Bupleuri 1500g, Fructus Gardeniae 1300g; Fructus Forsythiae 1500g, Radix Rehmanniae Preparata 1500g, Ramulus Cinnamomi 1200g, Fructus Ligustri Lucidi 1500g; Herba Hedyotidis Diffusae 1500g, Radix Ophiopogonis 1500g, Flos Carthami 1500g, Radix Paeoniae Alba 1500g; Radix Notoginseng 1500g, Radix Polygoni Multiflori Preparata 1500g, Poria 1000g, Retinervus Luffae Fructus 1500g; Rhizoma Chuanxiong 1500g, Rhizoma Curcumae 1500g, Radix Scutellariae 1500g, Flos Albiziae 1500g; Bombyx Batryticatus 1500g, Radix Angelicae Sinensis 1500g, Semen Platycladi 1500g; Add 10 times amount ethanol, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution merged, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.08 (20 DEG C); Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains component medicine; Tablet is pressed into amylodextrin.
The present invention or short time drop pill preparation method comprise the following steps: according to described component ratio of weight and number by Bombyx Batryticatus 1500g, Rhizoma Curcumae 1300g, Radix Pseudostellariae 1200g and the Radix Notoginseng 1200g water adding 5-7 times amount, put into multi-function extractor, keep air pressure at 0.04-0.06mPa, decoct 2 hours, extract its water soluble ingredient; Repeat above-mentioned steps and again extract 1.5 hours, extracting liquid filtering 100 mesh sieve; Use Macroporous Adsorption Resin filtrate, with ethanol elution; It is 1.33-1.35 that eluent is evaporated to density, and wherein input air pressure is 0.04-0.06mPa, and vacuum is-0.076-0.088mPa, stand for standby use; All the other component Radix Salviae Miltiorrhizaes 1200g, Radix Astragali 1200g, Radix Bupleuri 1500g, Fructus Gardeniae 1500g; Fructus Forsythiae 1500g, Radix Rehmanniae Preparata 1500g, Ramulus Cinnamomi 1500g, Fructus Ligustri Lucidi 1500g; Herba Hedyotidis Diffusae 1500g, Radix Ophiopogonis 1500g, Flos Carthami 1500g; Radix Paeoniae Alba 1500g, Radix Polygoni Multiflori Preparata 1500g, Poria 1500g; Retinervus Luffae Fructus 1500g, Rhizoma Chuanxiong 1500g, Radix Scutellariae 1500g; Flos Albiziae 1500g, Radix Angelicae Sinensis 1500g, Semen Platycladi 1500g; Add the water of its weight sum 5-7 times amount; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours; Filter extracting solution crosses 100 mesh sieves; Vacuum concentrated filtrate, to crude drug amount 1: 1W/V; Concentrated solution adds alcohol settling; Alcohol settling liquid 100 mesh sieves filter; Use sephadex chromatography is refined, with ethanol elution; Eluent is concentrated into density 1.33-1.35, leaves standstill; Get above-mentioned two kinds of standing drops to enter in dimethicone to cool to obtain drop pill.
Pill dripping machine technical parameter is as follows: drip irrigation temperature keeps 85-95 DEG C, and condensed fluid liquid paraffin temperature is lower than 8 DEG C, and water dropper internal diameter is 1.6mm, and water dropper external diameter is 2.5mm, and water dropper distance liquid paraffin surface distance is 15cm; Centrifugal, rotating speed 800-1100rpm, after 15 minutes, except deparaffnize.For quick acting, drop pill of the present invention be made into can in Sublingual the piller of rapid solution absorption, it can enter blood fast, through cardiac muscle.
Toxicology test:
Experimental example 1: acute toxicity test of the present invention
One, test material:
Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: Tablets, containing 0.0365g crude drug/sheet
Two, method:
1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolve tablet adding distil water, are made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.
2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Tablet adding distil water is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.
Three, result of the test:
In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.
Experimental example 2: aggregate toxicity is tested:
The agent of Chinese medicine preparation of the present invention honey refining for oral administration pill presses 7.69,19.18 and 43.21g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine preparation oral capsule of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Experimental example 3: anti-CB3 Viral Assay result display in body: drop pill of the present invention has significant protective effect to the virogenetic Mice Viral Myocarditis of CB3; neutralizing antibody concentration in Mice Body can be improved; obvious suppression Vero necrocytosis rate; its inhibition percentage can reach 400%, and obviously reduces administration group mice serum virus titer.Pathological examination shows, and the pathological change of administration group mouse cardiac myocytes is significantly less than virus control group, points out and has therapeutical effect to viral myocarditis.
Experimental example 4: the test display of open chest anesthetized cardiac hemodynamics of dogs: drop pill of the present invention can obviously reduce arteriotony and total peripheral resistance; Reduce coronary resistance, increase coronary flow; Reduce left indoor pressure, left room EDP, ± dp/dtmax; Increase cardiac output, cardiac index and SI; And reduce myocardium coefficient of oxygen utilization and oxygen consumption index.To heart rate and electrocardiogram without obvious shadow noon.In sum, this medicine can reduce load before and after heart, reduces cardiac work, and increases blood supply of cardiac muscle oxygen supply, reduces myocardial oxygen consumption, although weaken myocardial contraction, does not reduce cardiac output, have certain protective role to the heart of viral myocarditis.
Experimental example 5: the Acute Myocardial Ischemia in Rats test display of anti-Induced By Isoprenaline: drop pill of the present invention obviously can resist ECG change and the sick experimental example 8 of the Acute Myocardial Ischemia in Rats that isoproterenol brings out: the myocardial ischemia test display that anti-pituitrin brings out: drop pill of the present invention obviously can resist the ECG change of the Acute Myocardial Ischemia in Rats that pituitrin brings out.
Therefore; can think that this product has anti-CB3 virus from results of pharmacodynamic test; protecting myocardial cell; increase the blood supply oxygen supply of cardiac muscle; improve myocardial ischemia and antiarrhythmic effect; be the medicine of a comparatively ideal treatment viral myocarditis, the result of clinical trial also further demonstrates its curative effect.
Pharmacological experiment:
Experiment 1: on the impact of Mice Viral Myocarditis
(1) test material
Animal: Swiss mice, in age in male and female half and half, 3-4 week, 16-18g, is provided by Shandong University's medical board Experimental Animal Center.
Medicine: Quinquefolium saponin, positive control drug is the present invention's honey refining pill.
(2) test method and result
Mice is contained 10 4 TCID 50 CVB 3 liquid 0.2ml through intraperitoneal inoculation, after 1h, gastric infusion, successive administration two weeks.The virus of model control group mouse inoculation same dose, every day to the normal saline gavage of same dose, continuous two weeks.After last administration, pluck eyeball and get blood, separation of serum measures myocardium three enzyme glutamic oxaloacetic transaminase, GOT AST, creatine phosphokinase CK, lactate dehydrogenase L DH.The results are shown in Table 2.
Table 2 is on the impact (X ± s) of myocardial tissue of mice with viral myocarditis three enzyme
Note: with virus control group than * p < 0.05, * * p < 0.01
Result shows, drop pill of the present invention significantly can reduce Myocarditis Model animal blood Myocardial three enzyme, has the effect for the treatment of viral myocarditis.
Experiment 2: impact barium chloride being caused to rat ventricular
(1) test material
Medicine: test uses positive drug Effect of Shuxinsu Capsule, lot number: 941102.Thered is provided by Jian Pharmaceutical Factory of Jilin Province.Barium chloride, is produced by Kaiyuan chemical reagent factory.Animal: wistar rat, body weight 200-250g, purchased from Chinese medicine academy animal housing of Shandong Province.
(2) test method and result
Get 45 rats, be divided into five groups at random: model group, Effect of Shuxinsu Capsule 140mg/kg dosed administration group, drop pill of the present invention 140,70,35mg/kg dosage group.Every day gastric infusion twice, successive administration five days, after last administration 1 hour, anaesthetizes in rats by intraperitoneal injection chloral hydrate 300mg/kg, measures normal II lead electrocardiogram.Then sublingual vein injection barium chloride 4mg/kg, observes ECG Change.Record electrocardiogram in 20 minutes and recover normal number of animals and arrhythmia persistent period.The results are shown in Table 2.
Table 2 causes the impact of rat ventricular to barium chloride
Note: with model control group than * p < 0.05
Result shows, there is tachycardia immediately after rat intravenous injection barium chloride, the arrhythmia electrocardiograms such as ventricular premature contraction, take animal of the present invention and arrhythmia symptom can be made to be eased, recover normal number of animals in 20 minutes obviously to increase, and shorten the ARR persistent period.
Experiment 3: impact isoproterenol being caused to myocardial ischemia in rats
(1) test material
Animal: wistar rat, body weight 200-250g, purchased from Shandong Chinese medicine academy animal housing.
Medicine: Quinquefolium saponin; SHENGMAI ZHUSHEYE, is produced by Pharmacuetical Plant of Huaxi Medical Univ., lot number: 970403.Isoprenaline Iso injection: produced by Shanghai Hefeng Pharmaceutical Co., Ltd., lot number: 951002.
(2) test method and result
Get 60 rats, be divided into six groups at random: blank group, ischemia model group, SHENGMAI ZHUSHEYE 4.5ml/kg dosed administration group, Quinquefolium saponin 20,10,5mg/kg tri-dosage groups.Once a day, continuous intravenous injection administration three days.After last administration 30 minutes, except blank group, all the other animals equal subcutaneous injection Iso 8mg/kg, was administered once after 24 hours again.First 30 minutes of last administration subcutaneous injection Iso 2mg/kg again, anaesthetizes animal with chloral hydrate 300mg/kg for after last administration 15 minutes.Abdomen venous blood collection, separation of serum, measures CK, AST, LDH activity; Then by animal sacrificed by decapitation, take out heart rapidly, nose part of coring, fix in 10% formalin, make pathologic finding; Separately to core room muscular tissue, in 0-4 DEG C of homogenate, measure the active and MDA content of wherein SOD.The results are shown in Table 3.
Table 3 causes the impact (X ± s) of rats with myocardial ischemia cardiac muscle three enzymes to isoproterenol
Note: compare with blank group: * P < 0.05, * P < 0.01, * * P < 0.001 compares with model group: #P < 0.05, ##P < 0.01, ##P < 0.001
From result, after myocardial ischemia appears in animal, serum Myocardial three enzyme obviously raises, and particularly CK and AST is apparently higher than blank group.Injection Quinquefolium saponin and SHENGMAI ZHUSHEYE obviously can suppress the rising of CK and AST, and Radix Panacis Quinquefolii saponin also can reduce the activity of LDH, shows obvious function of resisting myocardial ischemia.
Clinical experiment:
Viral myocarditis be a kind of caused by viral infection based on the disease of myocardial inflammation pathological changes.Cause this sick most commonly encountered diseases poison to be Coxsackie B_3 virus in enterovirus, other also have the multiple virus such as echovirus, adenovirus, influenza virus, hepatitis virus.Still lack specific treatment measure at present for this disease, we adopt independent research Chinese medicine preparation to treat caused by hepatic stagnation qi stagnation viral myocarditis 60 example, and obtain satisfactory effect, and existing report is as follows.
1 materials and methods
1.1 physical data
Case (2006-2009) 60 example is observed in this research, and the standard drafted with reference to national myocarditis, cardiomyopathy workshop in 1987 is diagnosed as stagnation of QI due to depression of the liver viral myocarditis.Be divided at random and hinder peaceful group of flesh (treatment group) 30 example, wherein man 17 example, female 13 example; 11 ~ 42 years old age, average (25 ± 1.4) year; Course of disease 7d ~ 10 month, average (3.2 ± 0.15) individual month.Matched group 30 example, man 15 example, female 15 example; 9 ~ 47 years old age, average (25 ± 1.5) year; The course of disease 5 ~ 9 months, average (3.2 ± 0.52) individual month.Treatment group and matched group patient all have electrocardiographic abnormality in various degree, are respectively premature beat person 10,11 example, arrhythmia person 4,6 example, sinus tachycardia person 3,3 example, sinus bradycardia person 3,4 example, atrioventricular block person 7,4 example, bundle branch block person 3,2 example.Two groups of physical data, through statistical procedures, have comparability, P > 0.05 no difference of science of statistics in sex, age, the course of disease etc.
Chinese medical discrimination is with reference to the myocarditic guideline of clinical investigations of stagnation of QI due to depression of the liver of Ministry of Public Health formulation in 1993; For evil poison invades the heart, syndrome of deficiency of both qi and yin.Main manifestations is vexed uncomfortable in chest, cardiopalmus, uncomfortable in chest or chest pain, shortness of breath and fatigue, spontaneous perspiration or night sweat, large dry stool, red urine, red tip of the tongue, yellow fur, swift pulse number, counts unable or slow or knot, generation, short accurately.
1.2 Therapeutic Method
Two groups of patients all avoid fatigue, prevent from suffering from cold, take a good rest.All give regular western medicine treatment: western medical treatment method: (1) oxygen uptake; (2) liquid measure is controlled; (3) infection control, uses corresponding antibiotic and antiviral therapy according to nosetiology.Can use dexamethasone during heart failure, application digoxin controls heart failure etc.Large doses of vitamin C, fructose 1,6-diphosphate, coenzyme Q10 and symptomatic treatment.Correct severe arrhythmia.Treatment prescription Radix Bupleuri 10g, Fructus Gardeniae 15g, Fructus Forsythiae 10g, Radix Pseudostellariae 10g, Radix Rehmanniae Preparata 10g, Ramulus Cinnamomi 15g, Fructus Ligustri Lucidi 15g, Herba Hedyotidis Diffusae 10g, Radix Ophiopogonis 10g, Radix Salviae Miltiorrhizae 10g, Flos Carthami 15g, Radix Paeoniae Alba 10g, Radix Notoginseng 10g, Radix Astragali 15g, Radix Polygoni Multiflori Preparata 15g, Poria 10g, Retinervus Luffae Fructus 10g, Rhizoma Chuanxiong 10g, Rhizoma Curcumae 15g, Radix Scutellariae 10g, Flos Albiziae 10g, Bombyx Batryticatus 10g, Radix Angelicae Sinensis 15g, Semen Platycladi 10g: make granule by Chinese medicine preparation research and development centre of this institute, each 5g, every day 3 times.1 month course for the treatment of, complication person is had to give anti symptom treatment.
1.3 observation of curative effect
Symptom and sign: cardiopalmus, uncomfortable in chest, chest pain, to breathe hard and the symptom such as weak; The signs such as heart rate, the rhythm of the heart, die Blausucht, pulmonary's sound.
Lab index: virucidin measures.
1.4 curative effect determinate standard
By the curative effect determinate standard that ministry of Health of China in 1993 " guideline of clinical investigations of new Chinese medicine treatment viral myocarditis " is formulated.Recovery from illness: clinical symptoms, sign disappear, viral coherent detection index recovers normal; Effective: clinical symptoms, sign disappear substantially, viral coherent detection index recovers normal substantially; Effective: clinical symptoms, sign make moderate progress, viral coherent detection index has certain improvement; Invalid: clinical symptoms, sign and viral coherent detection index are all without improvement.
1.5 statistical method
Index is different according to the observation, and enumeration data adopts χ
2inspection, P < 0.01; Or P < 0.05; Or 0.01 < P < 0.05 be shown with remarkable statistical significance, P > 0.05 shows without significantly
Statistical significance, application software X 2 test computer V1.61 statistical analysis.
2 results
The evaluation of 2.1 clinical efficacies
As can be seen from Table 1, two groups of clinical efficacies, treatment group cure-remarkable-effectiveness rate is 86.67%, and total effective rate is 96.67%; Matched group cure-remarkable-effectiveness rate is 36.67%, and total effective rate is 60.00%, and difference has significant (P < 0.01).
Table 1 liang group Clinical efficacy comparison [example (%)]
Note: treatment group compares significant difference with matched group, χ
2=11.67, * P < 0.01
2.2 main symptoms are improved and are evaluated
As can be seen from Table 2, two groups of each symptoms all have improvement in various degree, treatment group cardiopalmus, uncomfortable in chest, chest pain, to breathe hard and weak symptom is improved and is obviously better than matched group.
A table 2 liang group cardinal symptom compares with efficacy result (example)
Note: treatment group compares significant difference with matched group, * * P < 0.01, * P < 0.05 or 0.01 < P < 0.05
Primary disease diseases caused by exogenous pathogenic factor person is in the majority with wind heat, and heat is YANG pathogen, easy injury-gas consumption, therefore supplementing QI and nourishing YIN is treatment primary disease rule for the treatment of.Result of study display TCM Therapy fundamentally can adjust the immune state of patients with myocarditis body complexity, can obviously reduce too high Immunoglobulin IgA, IgG, eliminate antimyocardial antibody, free radical, by clearing away phlegm, dredging collateral, removing blood stasis with potent drugs, can suppress to decompose myocardial fibrosis tissue, and have and obviously prevent myocardial remodelling, prevent myocarditis to be converted into dilated cardiomyopathy effect, anti-recurrence, clinic is applied.
Specific embodiment 1: river, man, 55 years old, because having palpitation, breathing hard 1d, increases the weight of 4h, in June, 2008.Rabat is pointed out: left ventricle dilation; Electrocardiogram dynamic monitoring checks: myocardial strain; Take place frequently room early; Arrhythmia.Be diagnosed as " viral myocarditis ".Patient's sensation of oppression over the chest with shortness of breath, dry mouth with bitter taste, pale tongue with white fur, is hard and dry, and vexed gas is hot-tempered, deep-thready pulse.Chinese medical discrimination is deficiency of both QI and YIN.Control with supplementing QI and nourishing YIN, nourishing yin and promoting blood circulation, side uses Radix Bupleuri 15g, Fructus Gardeniae 15g, Fructus Forsythiae 10g, Radix Pseudostellariae 10g, Radix Rehmanniae Preparata 10g, Ramulus Cinnamomi 15g, Fructus Ligustri Lucidi 10g, Herba Hedyotidis Diffusae 10g, Radix Ophiopogonis 10g, Radix Salviae Miltiorrhizae 10g, Flos Carthami 15g, Radix Paeoniae Alba 10g, Radix Notoginseng 10g, Radix Astragali 15g, Radix Polygoni Multiflori Preparata 10g, Poria 10g, Retinervus Luffae Fructus 10g, Rhizoma Chuanxiong 10g, Rhizoma Curcumae 15g, Radix Scutellariae 15g, Flos Albiziae 10g, Bombyx Batryticatus 10g, Radix Angelicae Sinensis 15g, Semen Platycladi 10g: plus-minus, be equipped with 10% glucose injection 250mL and add SHENGMAI ZHUSHEYE 30mL intravenous drip, 1 time on the 1st.Nurse based on psychology and living nursing, through treatment by Chinese herbs and the TCM holistic nursing care of more than 20 days, transference cure, use again pill of the present invention after one month electrocardiogram recover normally, recovery from illness is left hospital.。
Specific embodiment 2: poplar, female, 18 years old, sufferer had hepatitis history, and irritability, like sulky, personality haze, cardiopalmus takes place frequently, in March, 2009, my institute checks, disease sees severe palpitation, do during cardiopalmus, vexed breast is vexed, insomnia and dreamful sleep, bitter taste in the mouth and dry throat, constipation is dizzy, sensation of oppression over the chest with shortness of breath, spiritlessness and weakness, spontaneous perspiration or night sweat, red tip of the tongue, thin fur, stringy and rolling pulse or short type of deficiency of both the heart and spleen, when disease sees cardiopalmus, shortness of breath and fatigue, breast is vexed, feel dizzy, insomnia and dreamful sleep, indigestion and loss of appetite spontaneous perspiration, pale tongue, white and thin fur, thready pulse or knot, generation, control with supplementing QI and nourishing YIN, nourishing yin and promoting blood circulation, side uses Radix Bupleuri 15g, Fructus Gardeniae 15g, Fructus Forsythiae 10g, Radix Pseudostellariae 10g, Radix Rehmanniae Preparata 10g, Ramulus Cinnamomi 15g, Fructus Ligustri Lucidi 10g, Herba Hedyotidis Diffusae 10g, Radix Ophiopogonis 10g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 15g, Radix Paeoniae Alba 10g, Radix Notoginseng 15g, Radix Astragali 15g, Radix Polygoni Multiflori Preparata 10g, Poria 10g, Retinervus Luffae Fructus 15g, Rhizoma Chuanxiong 10g, Rhizoma Curcumae 15g, Radix Scutellariae 15g, Flos Albiziae 10g, Bombyx Batryticatus 10g, Radix Angelicae Sinensis 15g, Semen Platycladi 15g: through the treatment of month, the state of an illness is stablized with becoming, but there is slight cardiac dilatation, cardiac kinetic energy goes down, arrhythmia or ECG Change, through the treatment of 3 months, patient fully recovers, do not leave over any Sx.
Specific embodiment 3: go into business certain, man, 21 years old, irritability was liked to get angry at ordinary times, likes eating peppery, is fond of drinking and eats barbecue, and insomnia is irritated; Come my institute to check, do when disease sees cardiopalmus, vexed uncomfortable in chest, insomnia and dreamful sleep, bitter taste in the mouth and dry throat, constipation; yellowish or reddish urine, liver-fire expectorant heat, red tongue; yellow and greasy fur; stringy and rolling pulse or short, auxiliary examination: numeration of leukocyte raises, electrocardiographic abnormality; myocardial damage ST-T changes, and is diagnosed as viral myocarditis after diagnosis.Western medicine is cut out to patient, turn Chinese traditional treatment, Fang Yong: side uses Radix Bupleuri 15g, Fructus Gardeniae 15g, Fructus Forsythiae 10g, Radix Pseudostellariae 10g, Radix Rehmanniae Preparata 10g, Ramulus Cinnamomi 15g, Fructus Ligustri Lucidi 10g, Herba Hedyotidis Diffusae 10g, Radix Ophiopogonis 10g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 15g, Radix Paeoniae Alba 10g, Radix Notoginseng 15g, Radix Astragali 15g, Radix Polygoni Multiflori Preparata 10g, Poria 10g, Retinervus Luffae Fructus 15g, Rhizoma Chuanxiong 10g, Rhizoma Curcumae 15g, Radix Scutellariae 15g, Flos Albiziae 10g, Bombyx Batryticatus 10g, Radix Angelicae Sinensis 15g, Semen Platycladi 15g takes according to medicine pill of the present invention, daily three times, each 3 balls, conventional lying up is given when viral myocarditis acute attack, oxygen uptake, Energy mixture, nurse based on psychology and living nursing, through treatment by Chinese herbs and the TCM holistic nursing care of more than 30 days, transference cure, use again pill of the present invention after 2 months electrocardiogram recover normal, recovery from illness is left hospital.Follow up a case by regular visits to without recurrence.
Claims (9)
1. treat the Chinese medicine preparation of caused by hepatic stagnation qi stagnation viral myocarditis for one kind, it is characterized in that, in described Chinese medicine preparation, the parts by weight of various crude drug are: Radix Bupleuri 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Fructus Forsythiae 10 ~ 20 parts, Radix Pseudostellariae 10 ~ 20 parts, Radix Rehmanniae Preparata 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Herba Hedyotidis Diffusae 10 ~ 20 parts, Radix Ophiopogonis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, the Radix Paeoniae Alba 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, 10 ~ 20 parts, Poria, Retinervus Luffae Fructus 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Bombyx Batryticatus 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Semen Platycladi 10 ~ 20 parts.
2. treat the Chinese medicine preparation of caused by hepatic stagnation qi stagnation viral myocarditis according to claim 1, it is characterized in that, in described Chinese medicine preparation, the parts by weight of various crude drug are: Radix Bupleuri 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Fructus Forsythiae 10 ~ 15 parts, Radix Pseudostellariae 10 ~ 15 parts, Radix Rehmanniae Preparata 10 ~ 15 parts, Ramulus Cinnamomi 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Herba Hedyotidis Diffusae 10 ~ 15 parts, Radix Ophiopogonis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, the Radix Paeoniae Alba 10 ~ 15 parts, Radix Notoginseng 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, 10 ~ 20 parts, Poria, Retinervus Luffae Fructus 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Bombyx Batryticatus 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Semen Platycladi 10 ~ 20 parts.
3. treat the Chinese medicine preparation of caused by hepatic stagnation qi stagnation viral myocarditis according to claim 1, it is characterized in that, in described Chinese medicine preparation, the parts by weight of various crude drug are: Radix Bupleuri 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Fructus Forsythiae 10 ~ 20 parts, Radix Pseudostellariae 10 ~ 20 parts, Radix Rehmanniae Preparata 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Herba Hedyotidis Diffusae 10 ~ 20 parts, Radix Ophiopogonis 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, the Radix Paeoniae Alba 10 ~ 20 parts, Radix Notoginseng 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, 10 ~ 15 parts, Poria, Retinervus Luffae Fructus 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Rhizoma Curcumae 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, Bombyx Batryticatus 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Semen Platycladi 10 ~ 15 parts.
4. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine preparation of caused by hepatic stagnation qi stagnation viral myocarditis, it is characterized in that, described Chinese medicine preparation dosage form is honey refining pill, and its preparation process is:
A. first Radix Pseudostellariae, Radix Salviae Miltiorrhizae and Radix Astragali ethanol are refined;
B. again the medicinal residues refined and all the other crude drug are put into multi-function extractor extracting in water;
C. then by extracted twice thing combination drying powdering, add Mel and be twisted into pill.
5. preparation method according to claim 4, is characterized in that, in described step a, get Radix Pseudostellariae, Radix Salviae Miltiorrhizae and the Radix Astragali and add in the ethanol of its weight portion 5-10 times amount, extract 2 times; Heating extraction 1-2 hour, is concentrated into mass shape.
6. preparation method according to claim 4, is characterized in that, in described step b, the medicinal residues refined and all the other crude drug is put into multi-function extractor, adds in the water of 5-10 times amount, extract 2 times; Heating extraction 1-2 hour, is concentrated into mass shape.
7. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine preparation of caused by hepatic stagnation qi stagnation viral myocarditis, it is characterized in that, the dosage form of described medicine is drop pill, and its preparation process comprises:
A. first by Bombyx Batryticatus, Rhizoma Curcumae, Rhizoma Chuanxiong and Radix Notoginseng are extracted; Adsorb for subsequent use;
B. again all the other components are put into water to extract; Sedimentation and filtration, leaves standstill;
C. get above-mentioned two kinds of standing drops to enter in dimethicone to cool to obtain drop pill;
In described step a, according to described component ratio of weight and number, by Bombyx Batryticatus, Rhizoma Curcumae, Rhizoma Chuanxiong and Radix Notoginseng add the water of its weight sum 5-7 times amount, put into multi-function extractor, keep air pressure to decoct 2 hours at 0.04-0.06mPa, extract its water soluble ingredient; Extracting liquid filtering 100 mesh sieve; Ethanol elution after filtrate is refined with adsorbent resin; Eluent is evaporated to density 1.33-1.35, and wherein input air pressure is 0.04-0.06mPa, and vacuum is-0.076 ~-0.088mPa, stand for standby use.
8. preparation method according to claim 7, is characterized in that, in described step b, then all the other components are added the water of its weight sum 5-7 times amount; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours; Filter extracting solution crosses 100 mesh sieves; Vacuum concentrated filtrate, to crude drug amount 1: 1W/V; Concentrated solution adds alcohol settling; Alcohol settling liquid 100 mesh sieves filter; Use sephadex chromatography is refined, with ethanol elution; Eluent is concentrated into density 1.33-1.35, leaves standstill.
9. according to any one of claims 1 to 3, treat the Chinese medicine preparation of caused by hepatic stagnation qi stagnation viral myocarditis, it is characterized in that, its dosage form is: tablet, capsule, oral liquid, suck agent, granule, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, drop pill or extractum.
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| CN103285288B (en) * | 2013-06-26 | 2015-02-18 | 蒋梅 | Medicament for treating chronic cardiac insufficiency |
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| CN104116945A (en) * | 2014-07-02 | 2014-10-29 | 王统述 | A traditional Chinese medicine pill for treating viral myocarditis |
| CN104435262B (en) * | 2014-08-12 | 2015-08-26 | 榆林市第一医院 | A kind of pharmaceutical composition for the treatment of infantile viral myocarditis |
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