CN102772748A

CN102772748A - Traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis and preparation method thereof

Info

Publication number: CN102772748A
Application number: CN2012102988702A
Authority: CN
Inventors: 刘冰甜
Original assignee: 杨高林
Current assignee: GE CUILI; Liu Hongxia; Wu Caixia
Priority date: 2012-08-21
Filing date: 2012-08-21
Publication date: 2012-11-14
Anticipated expiration: 2032-08-21
Also published as: CN102772748B

Abstract

The invention provides a traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis. The traditional Chinese medicine preparation comprises the following components in parts by weight: 10-20 parts of radix bupleuri, 10-20 parts of cape jasmine, 10-20 parts of fructus forsythiae, 10-20 parts of radix pseudostellariae, 10-20 parts of prepared rehmannia root, 10-20 parts of cassia twig, 10-20 parts of fructus ligustri lucidi, 10-20 parts of oldenlandia diffusa, 10-20 parts of radix ophiopogonis, 10-20 parts of the root of red-rooted salvia, 10-20 parts of carthamus tinctorius, 10-20 parts of radix paeoniae alba, 10-20 parts of pseudo-ginseng, 10-20 parts of astragalus mongholicus, 10-20 parts of prepared fleece flower root, 10-20 parts of poria cocos, 10-20 parts of vegetable sponge, 10-20 parts of ligusticum wallichii, 10-20 parts of curcuma zedoary, 10-20 parts of scutellaria baicalensis, 10-20 parts of albizia julibrissin, 10-20 parts of silkworm larva, 10-20 parts of angelica sinensis, and 10-20 parts of platycladi seeds. The traditional Chinese medicine preparation disclosed by the invention is capable of rapidly in-flowing blood, directly achieving myocardium and rapidly increasing myocardial contraction force and has the main functions of detoxifying, removing stasis, clearing heat, opening the inhibited lung-energy and clearing away the heart-fire; in addition, the functions of tonifying qi and calming the mind and the functions of soothing the liver and reducing heat are combined, the functions of rapidly relieving patient conditions and saving lives of patients are achieved.

Description

A kind of Chinese medicine preparation of treating the caused by hepatic stagnation qi stagnation viral myocarditis and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of Chinese medicine preparation of treating the caused by hepatic stagnation qi stagnation viral myocarditis and preparation method thereof.

Background technology

Can find in research medically, cause that myocarditic reason can be divided into: virus, antibacterial, fungus or parasite, external condition such as physics in addition, chemical factor or the like all can cause myocarditis.Myocarditis is meant myocardium limitation or diffuse acute or chronic inflammatory disease pathological changes, can be divided into infectious and non-infectious two big types.Infectious myocarditis can be caused that non-infectious myocarditis then comprises allergy or allergy myocarditis by virus, antibacterial, spirillum, rickettsia, mycete, protozoon, anthelmintic, like myocarditis of rheumatism and chemical factors or drug-induced etc.Myocarditic symptom weight differs, and varying degree is in a bad way.But the lighter's no conscious sympton; Severe patient can show as sudden death, severe arrhythmia, cardiogenic shock or heart failure, causes acute stage dead; Also can show as various arrhythmia, pericarditis or acute myocardial infarction etc.The caused by hepatic stagnation qi stagnation viral myocarditis, general disease is seen severe palpitation, does during cardiopalmus, and is vexed uncomfortable in chest, insomnia and dreamful sleep, bitter taste in the mouth and dry throat, constipation is dizzy, sensation of oppression over the chest with shortness of breath, spiritlessness and weakness, spontaneous perspiration or night sweat, red tip of the tongue, thin fur, stringy and rolling pulse or short.Liver-fire is vigorous to cause that the most easily vexed gas is hot-tempered, bitter taste in the mouth and dry throat, and constipation is main so clinical needs detoxifcation clears away heart-fire; QI invigorating mind calming and soothing the liver expelling the heat-evil are share, and reach rapid mitigate the disease.

Viral myocarditis is one type of the most common clinically, that number of the infected is maximum myocarditis; Has popularity; Risen more than 10 times than sickness rate before 10 years now; Become the modal cardiomyopathy of China, pilosity be born among the crowd viral infection popular in, have 5% patient cause viral myocarditis approximately on the virus infected flow departure date.In recent years, the understanding of viral myocarditis is constantly deepened.Can cause that myocarditic virus is a lot, as: Coxsackie virus, adenovirus, influenza virus or the like, the myocarditis that wherein causes with change of coxsackie b virus especially see that at most because cardiac muscle is responsive especially to this virus performance, myocardium has special affinity to this virus.After the patient infection Coxsackie virus, 5% the heart that involves is arranged approximately.Focal necrosis all can take place in heart myocardial cell everywhere; With inflammatory cell infiltration, mainly be mononuclear cell in the necrosis region, neutrophilic granulocyte is also arranged sometimes, inflammatory cell reaction sometimes is not obvious.Necrosis region finally replaces for fibrosis, and the clinical manifestation of children virus myocarditis is grown up serious.Viral myocarditis does not have specific treatment so far, and modern medicine generally all is to adopt to suit the medicine to the illness and supporting treatment.Be mainly and alleviate the heart burden, take a good rest and nutrition; Carry out symptomatic treatment to symptoms such as the heart failure that occurs, arrhythmia simultaneously, and cardiac nutrition, the myocardial metabolism of improving, adrenocortical hormone used sometimes.After the increased in acute viral myocarditis, usually need convalescent treatment for a long time, half a year at least, have in addition 1-2, or longer a period of time.

At present, modern medicine does not still have the efficacious therapy method to viral myocarditis.The clinical manifestation of viral myocarditis has nothing in common with each other, and myocarditic symptom possibly come across the symptom phase or the convalescent period of protopathy, and as occurring in symptom phase of protopathy, its performance can be covered by protopathy.Most of patients has symptoms such as heating, systemic pain, pharyngalgia, diarrhoea at premorbid, reflection general viral infection, but part patient protopathy mild symptoms is also arranged and not remarkable, and carefully the side of questioning closely is noted, the myocarditis symptom is then relatively significantly.That myocarditis patient often tells is uncomfortable in chest, pareordia dull pain, cardiopalmus, weak, nauseating, dizzy.Clinically in the myocarditis of diagnosis, about 90% are chief complaint or head sees symptom with arrhythmia, and wherein small number of patients can take place to faint or Adams Stokes syndrome therefrom.Only a few patient rises after being ill, and development heart failure or cardiogenic shock occur rapidly.There is 60%～88% patient about morbidity the last fortnight, to have on heating, pharyngalgia, the general pain etc. pioneer such as sense or diarrhoea present approximately; Viral myocarditis has become the commonly encountered diseases in medical science internal medicine field; Hazardness is very big, but does not still have the Chinese medicine preparation of drug administration by injection safely and effectively so far; Do not have effective experience side clinically, flavour of a drug are more, and all adopt decoct oral, also do not have the Chinese medicine injection dosage form, and are slow to drug absorption for the more not only body of peroral dosage form, and use also inconvenient.Directly have influence on the therapeutic effect and the scope of application of the type medicine.

During this disease of clinical treatment, measures such as main employing anti-bolt medicine, nitrate esters medicine and bypass surgery treatment.The then Western medicine antibiotic that adopt of viral myocarditis more, for example oral ribavirin, intravenous injection inosine, aspara, vitamin C etc., its general effect is not obvious, and cure rate is low, and toxic and side effects is big.Western medical treatment is main with chemotherapy still, and treatment cycle is long, and side effect is big; Uncertain therapeutic efficacy is cut, and is difficult for adhering to, traditional Chinese medical science traditional therapy does not have the Chinese medicine of special treatment to come out yet; Do not have effective experience side clinically, flavour of a drug are more, and all adopt decoct oral; Also there is not the Chinese medicine injection dosage form, slow for the more not only body of peroral dosage form to drug absorption, and use also inconvenient.

Summary of the invention

Technical problem to be solved by this invention is, a kind of Chinese medicine preparation of treating viral myocarditis and preparation method thereof is provided, and remains in many deficiencies to the medicine of present treatment viral myocarditis; Like western medical treatment is main with chemotherapy still, and treatment cycle is long, and side effect is big; Uncertain therapeutic efficacy is cut, and is difficult for adhering to, traditional Chinese medical science traditional therapy does not have the Chinese medicine of special treatment to come out yet; Do not have effective experience side clinically, can only add and subtract with disease according to each doctor's clinical experience; And flavour of a drug are more, adopt decoct oral mostly, also do not have the Chinese medicine injection dosage form, use also inconvenience, and drug effect is slow.

For solving the problems of the technologies described above, the present invention provides a kind of Chinese medicine preparation of treating the caused by hepatic stagnation qi stagnation viral myocarditis, and disease is seen severe palpitation, does during cardiopalmus; Vexed uncomfortable in chest, insomnia and dreamful sleep, bitter taste in the mouth and dry throat, constipation is dizzy; Sensation of oppression over the chest with shortness of breath, spiritlessness and weakness, spontaneous perspiration or night sweat; Red tip of the tongue, thin fur, stringy and rolling pulse or short; The ratio of weight and number of various crude drug is in the said Chinese medicine preparation: 10～20 parts of Radix Bupleuri, 10～20 parts of Fructus Gardeniaes, 10～20 parts of Fructus Forsythiaes, 10～20 parts of Radix Pseudostellariaes, 10～20 parts of Radix Rehmanniae Preparata; 10～20 parts of Ramulus Cinnamomi, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Radix Ophiopogonis, 10～20 parts of Radix Salviae Miltiorrhizaes; 10～20 parts on Flos Carthami, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Radix Notoginseng, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Polygoni Multiflori Preparata; 10～20 parts in Poria, 10～20 parts of Retinervus Luffae Fructuss, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Scutellariaes; 10～20 parts of Flos Albiziaes, 10～20 parts of Bombyx Batryticatus, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Semen Platycladi.

The Chinese medicine preparation of said treatment caused by hepatic stagnation qi stagnation viral myocarditis, the ratio of weight and number of various crude drug can also be 10～15 parts of Radix Bupleuri, 10～15 parts of Fructus Gardeniaes, 10～15 parts of Fructus Forsythiaes, 10～15 parts of Radix Pseudostellariaes in the said Chinese medicine preparation; 10～15 parts of Radix Rehmanniae Preparata, 10～15 parts of Ramulus Cinnamomi, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Herba Hedyotidis Diffusaes; 10～15 parts of Radix Ophiopogonis, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts on Flos Carthami, 10～15 parts of the Radix Paeoniae Albas; 10～20 parts of Radix Notoginseng, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts in Poria; 10～20 parts of Retinervus Luffae Fructuss, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Scutellariaes; 10～20 parts of Flos Albiziaes, 10～20 parts of Bombyx Batryticatus, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Semen Platycladi.

The Chinese medicine preparation of said treatment caused by hepatic stagnation qi stagnation viral myocarditis is characterized in that, the ratio of weight and number of various crude drug also can be 10～20 parts of Radix Bupleuri, 10～20 parts of Fructus Gardeniaes, 10～20 parts of Fructus Forsythiaes in the said Chinese medicine preparation; 10～20 parts of Radix Pseudostellariaes, 10～20 parts of Radix Rehmanniae Preparata, 10～20 parts of Ramulus Cinnamomi, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Herba Hedyotidis Diffusaes; 10～20 parts of Radix Ophiopogonis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts on Flos Carthami, 10～20 parts of the Radix Paeoniae Albas; 10～15 parts of Radix Notoginseng, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～15 parts in Poria; 10～15 parts of Retinervus Luffae Fructuss, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Rhizoma Curcumae, 10～15 parts of Radix Scutellariaes; 10～15 parts of Flos Albiziaes, 10～15 parts of Bombyx Batryticatus, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Semen Platycladi.

For solving the problems of the technologies described above, the present invention also provides a kind of method for preparing of treating the Chinese medicine preparation of caused by hepatic stagnation qi stagnation viral myocarditis, and said pharmaceutical dosage form for the preparation process of honey refining pill is: a, elder generation refine Radix Pseudostellariae, Radix Salviae Miltiorrhizae and the Radix Astragali with ethanol;

B, the medicinal residues that will refine again and all the other crude drug are put into the multi-function extractor extracting in water;

C, then with extracted twice thing combination drying powdering, add Mel and be twisted into pill.

Among the said step a, can get Radix Pseudostellariae, Radix Salviae Miltiorrhizae and the Radix Astragali and add in the ethanol that 5-10 doubly measures, extract 2 times; Heating extraction 1-2 hour, be concentrated into the mass shape.

Among the said step b, can the medicinal residues that refine and all the other crude drug be put into multi-function extractor, in the water that adding 5-10 doubly measures, extract 2 times; Heating extraction 1-2 hour, be concentrated into the mass shape.

For solving the problems of the technologies described above, the present invention provides a kind of method for preparing of treating the Chinese medicine preparation of caused by hepatic stagnation qi stagnation viral myocarditis again, and the dosage form of said medicine is that the preparation process of drop pill comprises:

A, elder generation are with Bombyx Batryticatus, and Rhizoma Curcumae, Rhizoma Chuanxiong and Radix Notoginseng are extracted; Adsorb subsequent use;

B, again all the other components are put into water and extract; Sedimentation and filtration leaves standstill;

C, get above-mentioned two kinds leave standstill drop go into cool off in the dimethicone drop pill.

Among the said step a, can be according to said component ratio of weight and number with Bombyx Batryticatus, Rhizoma Curcumae, Rhizoma Chuanxiong and Radix Notoginseng add the water that its weight sum 5-7 doubly measures, and put into multi-function extractor, keep air pressure to decoct 2 hours at 0.04-0.06mPa, extract its water soluble ingredient; Extracting liquid filtering 100 mesh sieves; With the refining filtrating of adsorbent resin back ethanol elution; Eluent is evaporated to density 1.33-1.35, and wherein input air pressure is 0.04-0.06mPa, and vacuum is-0.076～-0.088mPa, stand for standby use;

Among the said step b, can again all the other components be added the water that its weight sum 5-7 doubly measures; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours; The filter extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate is to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitation liquid filters with 100 mesh sieves; The use sephadex chromatography is refining, uses ethanol elution; Eluent is concentrated into density 1.33-1.35, leaves standstill.

The present invention treats the dosage form of the Chinese medicine preparation of caused by hepatic stagnation qi stagnation viral myocarditis, its dosage form can for: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, drop pill or extractum.

Compared with prior art, the extract of the inventive method acquisition is convenient to the preparation of solid preparation.When extract of the present invention was prepared into solid preparation, usually extracting solution must the spray-dried extract powder that becomes, and granulate, thereby supplementary product consumption in the minimizing preparation reduces clinical taking dose again.If the sample liquid behind the water extract-alcohol precipitation is carried out spray drying, very easily sticking wall is difficult to obtain dried powder, and loss is very big, even obtain powder, because of hygroscopicity is very strong, also is difficult to process granule, makes troubles for the preparation of solid preparation.And the present invention through ultracentrifugal medicinal liquid because to remove impurity comparatively thorough, concentrate, after the spray drying, can obtain dry loose powdered, the back yield rate of granulating is high, can be suitable for large-scale production.

Drop pill machine technology parameter is following: the drip irrigation temperature keeps 85-95 ℃, and condensed fluid liquid paraffin temperature is lower than 8 ℃, and the water dropper internal diameter is 1.6mm, and the water dropper external diameter is 2.5mm, and water dropper is 15cm apart from the liquid paraffin surface distance; Centrifugal, rotating speed 800-1100rpm after 15 minutes, removes deparaffnize and gets final product.Be quick acting, drop pill of the present invention is made into to dissolve the piller of absorption in the Sublingual rapidly, and it can go into blood fast, and through cardiac muscle strengthens myocardial contraction rapidly, coronary blood flow increasing, and protecting myocardial cell improves cardiac function.

Beneficial technical effects of the present invention is: use the myocarditic medicine of selected Chinese medicinal material preparation treatment; The medicine of processing can not only improve myocardial metabolism, cardiac nutrition, protection heart cell; Improve the resistance against diseases of cardiac muscle; And ability direct killing virus, alleviate virus to induced myocardial injury, play antiviral and the integrally-regulated action effect that combines; Alleviate the Western medicine prolonged application to the side effect that human body produces, make it become the ideal myocarditic medicine that is used to treat, the present invention contains a large amount of active component, and raw material is cheap, and method for preparing is simple, can apply in the clinical practice in a large number.The present invention can go into blood fast, and through cardiac muscle strengthens myocardial contraction rapidly, and eliminating toxic substances to remove stasis, reducing heat and dispersing lung-QI, and it is main that detoxifcation clears away heart-fire; Supplementing QI and nourishing YIN and blood circulation promoting and blood stasis dispelling share, and QI invigorating mind calming and soothing the liver expelling the heat-evil are share, and diuretic can reduce phlegm; Reach rapid mitigate the disease, save the effect of sufferer life.And raw material is cheap, and method for preparing is simple, can apply in the clinical practice in a large number.

The specific embodiment

Viral myocarditis is clinical more common cardiac disorder, is mainly in teenager and middle age.The vigorous type myocarditis of deficiency of YIN liver-fire is to violate by evil poison is outer, the interior house due to the heart, and liver-fire type of phlegm-heat attacking the heart type is done when disease is seen cardiopalmus, and is vexed uncomfortable in chest, insomnia and dreamful sleep, bitter taste in the mouth and dry throat, constipation, yellowish or reddish urine, red tongue, yellow and greasy fur, stringy and rolling pulse; Belong to motherland's medical science " cardiopalmus " " palpitation with a distress feeling " " thoracic obstruction " categories such as " asthenia " more.The heart occupies in the heart, controlling blood and vessel, house mind.At body is arteries and veins, and arteries and veins is the house of blood.In battalion's row arteries and veins, defensive QI circulating outside the vessel, battalion defends root in middle Jiao, can be in cardiopulmonary.Exopathogen invasion and attack, chief criminal battalion defends, and it is evil to stagnate and does not loose, and stays and does not go, or go and not to the greatest extent, can follow sering, the interior house in the heart." qi being the governor of blood, blood being the material foundation of QI " again, the deficiency of vital energy is then agitated unable, and the blood deficiency then heart is lost and to be moistened fosterly, all can form primary disease.

Viral myocarditis relates to categories such as the traditional Chinese medical science " cardiopalmus ", " palpitation with a distress feeling ", " thoracic obstruction "; The Chinese medicine viral myocarditis has special advantages; According to for many years the treatment experience of this disease and experimentation being confirmed; Holding concurrently with the detoxifcation with supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind is method, and treatment is with syndrome of deficiency of both qi and yin or to hold the stasis of blood under the arm be that the viral myocarditis effect of main clinical manifestation is preferable.

Sui's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases " is said: " wind palpitation with fear person, empty by body, deficiency of heart-QI, the mansion of the heart is taken advantage of by ailment said due to cold or exposure, or frightened melancholy compels, and makes us the deficiency of vital energy, also receives in ailment said due to cold or exposure, ailment said due to cold or exposure is fought in the heart, and is then frightened from peace, shy endlessly then startle indefinite." " warm pathogen tend to attack the upper orifices, attacking the lung first, the pathogen attacking the pericardium adversely." so primary disease at the beginning of, see that evil poison attacks the disease of the criminal's of showing lung more, give up in the heart in the pathogen that continues, and occur that the motive is disturbed, qi-blood disharmony, the cloudy impaired all cards of gas of the heart.Mostly primary disease is that cardiopulmonary are with sick in early days.Disease to middle and late stage then mainly shows as the QIYINLIANGXU of the heart or the syndrome of QI and blood retardance.Difference such as factor body or inducement are also arranged, show as the gas YANG deficiency; Accumulate in the phlegm-damp; Liver and gall are hot and suffocating, deficiency of heart-QI; Or deficiency of heart-YANG and kidney-YANG, disease persons such as the heart attacked by pathogenic water.The sick position of primary disease is at the heart in a word, and holds concurrently and he is dirty.Pathogenesis belongs to void or deficiency in origin and excess in superficiality, and is mostly the simulataneous insufficiency and excessive syndrome.The common Q-T of electrocardiogram interval, prolong, and the T popin is smooth or be inverted various arrhythmia such as frequent premature beat, I, the atrioventricular block of II degree, sinus tachycardia etc.For the treatment of primary disease, the initial stage, it was main that detoxifcation clears away heart-fire with reducing heat and dispersing lung-QI; Middle and late stage is then biased respectively with supplementing QI and nourishing YIN according to the prosperity and decline of negative and positive of qi and blood, or supplementing QI and nourishing YIN and blood circulation promoting and blood stasis dispelling share, or QI invigorating mind calming and soothing the liver expelling the heat-evil share, or the Yangfu(jing-River point,GB 38) that helps heart kidney is with methods such as the diuretic that reduces phlegm.In the myocarditis course of disease, it is particularly important that Gu protects cloudy liquid, and its disease just has heresy of pyretic toxicity, and the wound of cloudy liquid is arranged in the disease, if with its deficiency of vital energy; Impose the tonics such as Radix Ginseng of big benefit, unsuitable in institute, if help it, remove deficiency of YIN heat first with Radix Panacis Quinquefolii, the Radix Astragali of the sweet cold of hardship; Second reinforcing both QI and YIN more helps the tonify deficiency of Radix Notoginseng, three frauds of restraining Radix Notoginseng, Bombyx Batryticatus property of medicine partial heat, four medicines help promoting blood circulation to remove blood stasis; It is eliminating evil to detoxify, its reinforcing both QI and YIN, and merit smooth and blood vessels is existing, the disease of " cardiopalmus ", " thoracic obstruction ", " palpitation with a distress feeling " must be controlled.

Radix Angelicae Sinensis invigorating the spleen and replenishing QI in the side, spermatogenesis nourishes blood; Radix Astragali tonifying Qi and lifting yang, the diuretic detumescent; Flos Carthami, Radix Salviae Miltiorrhizae and pseudo-ginseng blood-circulation-invigovating blood stasis dispelling; Rhizoma Curcumae promoting the circulation of QI the chest stuffiness relieving; The tangible coronary dilating of ginsenoside's tool, heart tonifying, reinforcement myocardial contraction, increase cardiac output, reduction myocardial oxygen consumption, reduction blood viscosity and peripheral vascular resistance effect; Simultaneously can reduce and eliminate oxygen-derived free radicals; Thereby the protection cardiac muscle is avoided ischemic injuries, invigorating the heart and spleen.All medicines share, and play altogether that spleen reinforcing is nourished heart, the merit of promoting the circulation of QI to induce diuresis, blood circulation promoting and blood stasis dispelling.Pharmacological research shows that the Radix Astragali has positive inotropic action, contains glucuronic acid, choline etc., can expand peripheral blood vessel, brings high blood pressure down, and strengthens myocardial contractility, improves cardiac output, can suppress the acid of platelet di-phosphate ester simultaneously, microcirculation improvement; But Radix Angelicae Sinensis, Flos Carthami, Radix Salviae Miltiorrhizae decreased heart rate increase coronary flow, and resisting myocardial ischemia strengthens myocardial contraction; But the Radix Pseudostellariae arrhythmia reduces heart rate, significantly reduces the arterial pressure peak value; Rhizoma Chuanxiong, the calm diuresis of ability Radix Ophiopogonis, blood vessel dilating improves coronary circulation; Radix Bupleuri, the Radix Paeoniae Alba the is soothing the liver heat clearing away of nourishing blood; Radix Polygoni Multiflori Preparata, Ramulus Cinnamomi improves human body vigour, tonifies Qi of the kidney; Herba Hedyotidis Diffusae is separated dispelling toxins and dredging collaterals; The relieving restlessness that clears away heart-fire of Semen Platycladi, Flos Albiziae, tranquilizing by nourishing the heart; Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthami, Radix Salviae Miltiorrhizae are the article of activating blood circulation and dissipating phlegm, to reach the effect of blood circulation promoting and blood stasis dispelling, regulating qi and dredging collateral.But the general medical history of the thoracic obstruction patient normal simulataneous insufficiency and excessive of length is to suffer from, and is so-called empty, not the void thanks to of exogenous QI, blood, yin, yang; Real is the stagnation of QI, turbid, the cold coagulation of expectorant often, so clinical need on essential drugs, with the card plus-minus, are executed flexibly and controlled.Bombyx Batryticatus, activating blood circulation to dissipate blood stasis and dredge the collateral in the side; The Radix Astragali, replenishing qi and promoting blood flow, the temperature gas that activates yang is to strengthen the merit of promoting blood circulation to remove obstruction in the collateral; The Fructus Ligustri Lucidi QI invigorating and body resistance strengthening is strengthened resistance.All medicines share and play the effect that promoting blood circulation to remove obstruction in the collateral, QI invigorating activate yang, giving consideration to both the incidental and fundamental altogether.Modern pharmacological research confirms, Radix Paeoniae Alba ability anticoagulant and thrombosis, and microcirculation improvement increases coronary blood flow; The extract of the Radix Astragali has cardiotonic, can improve heart stroke and cardiac index, and the Retinervus Luffae Fructus detoxifcation has effects such as blood vessel dilating, blood pressure lowering, microcirculation improvement simultaneously; Fructus Gardeniae has blood vessel dilating, excited heart, strengthens the effect of coronary blood flow and myocardial contraction.

The Radix Astragali is main with tonify deficiency, ability invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Chinese medicine astragalus sweet in the mouth, and tepor is returned the lung spleen channel; But ascending YANG and invigorating QI, and " pearl sac " " the sweet Wen Chunyang of the Radix Astragali, it is with having five: mend all empty deficiencies, one also; Benefit vigour, two also; Strong taste, three also; Go flesh heat, four also; The hemopoietic of invigorating blood circulation,, five also ".Modern pharmacological research is found: the Radix Astragali and effective ingredient astragaloside thereof and α-tyrosine have blood vessel dilating, reduce Peripheral resistance, thereby lightening heart load reduces myocardial oxygen consumption.The Radix Astragali can also improve the ability of myocardial cell anti-hypoxia " oxygen supply again " damage; Alleviate the damage of myocardial cells degree, keep the myocardial cell function of beating, improve myocardial cell energy metabolism protection cell ultrastructure; Improve SOD activity in the cell, strengthen the oxygen-derived free radicals ability of removing.Modern study is found: astragalin has positive inotropic action, has dose-effect relationship, and with Radix Astragali crude drug in calcium ion concentration irrelevant; And confirm that the astragalin IV is its effective ingredient, and it can make, and cAMP raises in the myocardial cell, activates the protein kinase of dependency ATP, makes the calciphorin phosphorylation, and flow of calcium ions increases; CAMP raises in the cell simultaneously, promotes the sarcoplasmic reticulum calcium ion to discharge, and strengthens thereby myocardial cell excitement-contraction Rhizoma Nelumbinis is joined.The Radix Astragali includes and multiple antibiotic effective ingredient, and the ability enhancing body's immunological function, therefore can also be used to prevent the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " Radix Astragali is can tonifying five ZANG-organs all empty, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.Its chemical constituent of Radix Salviae Miltiorrhizae mainly is divided into 2 types: one is fat-soluble TANSHINONES, and one is water solublity danshensu etc.No matter be clinical or the most scholars of experimentation have affirmed that Radix Salviae Miltiorrhizae has coronary artery dilator, improve myocardium anti-anoxia ability, the expansion peripheral blood vessel; Microcirculation improvement is regulated the reparation and the regeneration of tissue, activates fibrinolytic anticoagulant; Enhancing immunity, effect such as antibiotic grade.Especially it can improve myocardial contraction under the situation that does not influence oxygen consumption when core function badness, and decreased heart rate obviously improves cardiac function, and blood flow is quickened, and the capillary bed opening increases.

Flos Carthami is warm in nature, acrid in the mouth.Cure mainly the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy goes into the blood chamber, and delirium is gone mad; Or vexed interior the expanding of blood, the sudden syncope with rigidity is that all puerperal, non-Flos Carthami can not be decided at card as extremely.All friendship like the obstructed and cold and heat of amenorrhea done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollen burst uneasyly, is cards of disharmony between QI and blood all, and non-Flos Carthami can not be transferred." medicineization justice ": Flos Carthami, kind tonneau passages through which vital energy circulates is gas medicine in the blood, can rush down and can mend, and wonderful justice is respectively arranged.If many with three, four money, then too hot temperature is wandered away blood.With Lignum Sappan removing blood stasis blood, to close Cortex Cinnamomi and stimulate the menstrual flow and close, assistant is returned, Chinese herbaceous peony is controlled all over or the pricking caused by the stagnation of QI and blood of breast abdomen, and this its row is led and is invigorated blood circulation also.If use seven, eight fens less, with dispersing liver-energy, helping the sea of blood, the void of enriching blood greatly, this its transfer smooth and with blood also; If end with two, three minutes, go into the heart to join painstaking effort, dismiss heart channel pathogenic fire, make the blood mediation, this its nourishing and hemopoietic are also; The justice of component number, meagre.Modern experiment shows that Flos Carthami has tangible effect to cardiovascular system: suppress the heart effect 1.: Flos Carthami decoct low dose can make Bufo siccus isolated heart and rabbit in slightly excitement of systemic heart, makes heart beating strong, and amplitude strengthens; Heavy dose then has inhibitory action to heart, makes decreased heart rate, and myocardial contraction weakens, and SV reduces.2. the experimentation to CF shows: Flos Carthami water extract and Flos Carthami water soluble mixt-Carthamus yellow have the effect of coronary blood flow increasing and myocardial nutrition property blood flow; The coronary artery dilating of Flos Carthami ethanol extraction and the effect of coronary blood flow increasing are then not obvious or do not have an influence.3. the experimentation to expeirmental myocardial ischemia and myocardial infarction shows: cause on the animal model of expeirmental myocardial ischemia or myocardial infarction rabbit, rat, dog etc., Flos Carthami and preparation thereof all have antagonism in various degree.Flos Carthami can make the rat or the rabbit acute myocardial ischemia that cause because of pituitrin that obvious protective effect is arranged; Can make repeatedly of short duration blocking-up coronary flow cause the degree of anesthetized dog acute myocardial ischemia obviously to alleviate; Scope is dwindled; Decreased heart rate; And the edge in protection acute myocardial infarction district, district and dwindle infarction size and reduce the amplitude that the marginal zone ECG ST section is raised, thus improve the supply-demand relationship of ischemic myocardium oxygen.Thereby Flos Carthami have the hemodynamics of improving myocardial ischemia reperfusion injury and reaches the effect that protection cardiac muscle improves function because of containing safflower yellow.Safflower yellow have the effect that obvious coronary blood flow increasing improves blood supply of cardiac muscle.In addition, safflower yellow has the obvious suppression effect to endogenous and extrinsic coagulation, but significant prolongation prothrombin time and clotting time, and to many links of coagulation process such as platelet adhesion reaction, thrombosis and fibrin are crosslinked etc. has inhibitory action.

The sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock.Be rare Chinese medicine, but give birth to have good hemostasia effect, significant hemopoietic function with hemostasia and dissipation blood stasis, reducing swelling and alleviating pain; Can tighten and improve the arteria coronaria microcirculation, Radix Notoginseng is used as medicine with a long history, acts on peculiarly being regarded as the treasured in the medicine by ancient Chinese medicine doctor, so the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) " is arranged." it is little sweet and bitter to distinguish the flavor of, quite seemingly the flavor of Radix Ginseng for Radix Notoginseng." " all canes are pounced on trauma, and the dripping person of blood stasis chews promptly ending of mashed net for catching birds or fish immediately, and bruise the person promptly dissipate.If when receiving cane, clothes one, two money earlier, then the blood centre of punch not should be obeyed it behind the cane especially, and obey also good puerperal.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of the cloudy blood system of fainting, so can control all disorders of blood "." book on Chinese herbal medicine is looked for the truth " record: " Radix Notoginseng, common people only know the function hemostasis and pain-relieving.Hardly realize bitterly and ache work that blood ends because of applying the blood that looses because of blood stasis.The bitter temperature of Radix Notoginseng abnormal smells from the patient can be in its blood stasis of blood systemization." Radix Notoginseng ability coronary blood flow increasing, decreased heart rate reduces myocardial oxygen consumption, increases myocardium oxygen-resistant ability, and microcirculation improvement is removed the effect of smooth muscle spasm.

Radix Paeoniae Alba nourishing the liver is invigorated blood circulation.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.The Radix Paeoniae Rubra branch excess-heat that can purify the blood, dissipating blood stasis blood is detained.These article function and Cortex Moutan are close, so normal be usefulness with the Cortex Moutan mutual reinforcement between.But the effect of Cortex Moutan clearing away heat and cooling blood is preferable, and the branch excess-heat that can purify the blood can be controlled fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for the blood system excess-heat, is good at promoting blood circulation to remove blood stasis.

Sweet, the mildly bitter flavor of property Radix Ophiopogonis is slightly cold.GUIXIN, lung, stomach warp.Function with cure mainly YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Be used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Control dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation is quenched one's thirst, and hinder in calentura Tianjin, dry mouth and throat, constipation.These article are sweet cold clear and rich, the heat of the kind lung that clears away heart-fire and yin nourishing relieving restlessness, and holding concurrently can clear and rich gastrointestinal and quench the thirst and moisturize.Effect with anti-experimental character arrhythmia, increase coronary flow.

Rhizoma Chuanxiong is gone into liver, spleen, three warmers three warps.Function cures mainly activating QI to alleviate the depression, and the method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache and revolve dizzyly, the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." detailed outline " carries: " dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine is removed vascular smooth muscle (aortic article) spasm (epinephrine, potassium chloride cause).Can also expand coronary vasodilator, coronary blood flow increasing.The myocardial ischemia-anoxemia that the antagonism pituitrin causes.Alleviate the myocardial infarction lesion degree that the ligation arteria coronaria causes.

Rhizoma Curcumae is hot, bitter, temperature.Return liver, spleen channel.The removing blood stasis promoting the circulation of QI to relieve pain: these article effect is with triangular similar, but warm concerted effort is bigger, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.Long-pending eliminating stagnation: the pain relieving of these article ability circulation of qi promoting removing food stagnancy is used for eating accumulation, the breast abdominal distention is vexed has a pain.Removing blood stasis, women's amenorrhea, or the phlegm-damp congestion lump in the abdomen addiction piece that condenses and form.Promoting the circulation of QI to relieve pain: be suitable for drinking and eating irregularly, the card of gastral cavity abdomen overflow pain.Suitable compatibility, deficient syndrome, the case of a physically strong patient running a high fever all can.

Retinervus Luffae Fructus: dredge the meridian passage is arranged, the effect of removing toxic substances and promoting subsidence of swelling.Cure mainly pain in chest and hypochondrium; Rheumatic arthralgia, passages through which vital energy circulates contracture, galactostasis, lung gesture cough, carbuncle future sore, his carbuncle." book on Chinese herbal medicine is just read ": Retinervus Luffae Fructus, go into meridians, separate pathogenic heat.Evanescence of heat then wind goes, and the unlikely combination of body fluid in the network and be expectorant becomes all diseases of toxic swelling, the ear so cloud detoxifies.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs.Hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Radix Angelicae Sinensis: its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Fructus Ligustri Lucidi sweet in the mouth, hardship, cool in nature.Can take a tonic or nourishing food to build up one's health Liver and kidney, make eye bright.Contain oleanolic acid, mannitol, glucose, Palmic acid, glyceric acid.Raise immunity is arranged, and the rising peripheral leukocytes strengthens reticuloendothelial system phagocytic activity, strengthens the effect of cellular immunization and humoral immunization; Heart tonifying, diuresis are arranged and protect the liver, cough-relieving, cathartic, effect such as antibiotic, anticancer.Purposes: be used for the hepatic and renal YIN deficiency, soreness of waist tinnitus, early whitening of beard and hair; Unseeing, poor vision; Fever due to yin deficiency.Fructus Ligustri Lucidi, sweet-bitter flavor, cool in nature is returned the Liver and kidney warp, has the merit that nourishing the liver and kidney, tonifying YIN nourish blood.Modern medicine study proves that Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fatty wet goods, and heart tonifying, diuresis and hepatoprotective effect are arranged, and the leukopenia quantity that causes because of chemotherapy is raise, and staphylococcus aureus, escherichia coli are had inhibitory action.

The Herba Hedyotidis Diffusae Herba Hedyotidis Diffusae is Herba Hedyotidis Diffusae, two leaves, Herba Commelinae Bengalensis, Chinese Lobelia again.Mildly bitter flavor, sweet, cold.Go into stomach, large intestine, small intestine meridian, the clearing up internal heat by using drugs of bitter in taste and cold in nature detoxifcation, sweet cold eliminating damp-heat has stronger removing toxicity for eliminating carbuncles effect to carbuncle, pharyngalgia, snakebite etc.Generally be used to treat sore, laryngopharynx swelling and pain, abdominalgia with intestinal abscess, venom, also be used for the puckery pain of pyretic stranguria, dysuria.Be the good medicine of damp eliminating of drawing out pus by applying a plaster to the affected part.

Poria sweet in the mouth, light, property are flat, be used as medicine have promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria ability enhancing human body immunity function, pachyman has tangible antitumor and protects the liver dirty effect.But the deficiency and coldness essence is sliding or the collapse of QI person avoids clothes.Be used for diarrhea due to hypofunction of the spleen, the leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, for have loose bowels due to the insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, use the effect that Poria has giving consideration to both the incidental and fundamental, compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Be available as the tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

Semen Platycladi property is put down sweet in the mouth, the heart, kidney, large intestine channel.The effect of tool tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Control diseases such as palpitation with fear, insomnia, seminal emission, night sweat, constipation, ability tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Be used for restlessness of asrhenia type and insomnia, severe palpitation, dryness of the intestine makes the secret disease that Dengs." medicineization justice ": Semen Platycladi, fragrance passes through the heart, and the body profit is grown blood.Same Poria cum Radix Pini, Semen Ziziphi Spinosae, the Radix Rehmanniae, Radix Ophiopogonis are article clearly in turbid, and it is timid to cure mainly mind void, the palpitation with fear severe palpitation, and color is wan and sallow, the skin pruritus due to dryness, the merit of the blood that all nourishes heart is also.It is all dense to get abnormal smells from the patient again, returns kidney in turbid, and same Radix Rehmanniae Preparata, Carapax et Plastrum Testudinis, Fructus Lycii, Radix Achyranthis Bidentatae for packing bone marrow, cure mainly damage of kidney-YIN, the back severe disease, and sufficient knee joint is weak, night sweat due to yin deficiency, all the dry power of nourishing kidney is also.Sweet in the mouth also can delay liver, and the deficiency of tonifying liver gallbladder is extremely reliable, but the flat power of property is slow, suitable more than uses be wonderful.

Fructus Gardeniae is bitter, and is cold.GUIXIN, lung, tri-jiao channel.Be used for calentura heating, vexedly rather do not wait disease.Fructus Gardeniae is kind to expel the heat-evil and relieving restlessness in pathogenic fire purging.At the edema caused by disorder of QI disease initial stage of fever caused by exogenous pathogenic factors, see disease such as heating is arranged, uncomfortable in chest, vexed, available Fructus Gardeniae cooperates Semen Sojae Preparatum, with expelling pathogenic factors from the exterior expel the heat-evil, the relieving restlessness resolving depression.As belong to all excess-heat fire diseases and see diseases such as hyperpyrexia agitation, unconsciousness and delirium, available article are joined pathogenic fire purging such as Cortex Phellodendri and clear pathogen is warm.

Flos Albiziae contains the Herba Albiziae glycoside, tannin, and resolving stagnation for tranquilization, the appetizing of regulating the flow of vital energy, activating collaterals to relieve pain is used for irritability, melancholy insomnia.It is uncomfortable in chest to control pent-up, and insomnia is forgetful, and acute conjunctivitis can settling five organs, and will, improving healthy complexion, have preferably keep fit, calm, the effect of calming the nerves, improve looks, also be to treat neurasthenic good merchantable brand.Also has clearing away summer-heat, face-beautifying and spot-removing effect such as relieve the effect of alcohol." book on Chinese herbal medicine warp " said: " Flos Albiziae ability settling five organs, and will, improving healthy complexion." especially to the anemia of pregnant woman, have preferably keep fit, calm, the effect of calming the nerves, improve looks, also be to treat neurasthenic good merchantable brand.

Radix Bupleuri is bitter, is slightly cold.Return liver, gallbladder meridian.Function is brought down a fever soothing liver-QI, yang invigorating with curing mainly to evacuate.Be used for cold, fever, alternate attack of chill and fever, malaria, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.Be soothing the liver good medicine of fostering the spirit of nobility.

Ramulus Cinnamomi is hot, sweet, temperature.GUIXIN, lung, urinary bladder channel.Expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.The diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Be used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.1. antibacterial action: the Ramulus Cinnamomi ethanol extract can suppress escherichia coli, bacillus subtilis and staphylococcus aureus external, and valid density is 25mg/ml or following; Staphylococcus albus, dysentery bacterium, typhoid fever and paratyphoid fever bacillus, streptococcus pneumoniae, aerobacteria, Bacillus proteus, anthrax bacillus, Salmonella enteritidis, vibrio cholera etc. are also had 2. antivirus action of inhibitory action (flat board dig a hole method): cultivate with human embryo kidney (HEK) simple epithelium cell tissue of former generation, Ramulus Cinnamomi decoct (1: 20) has inhibitory action to the first type capital 68-l of section strain of influenza Asia and Orphan virus (ECHO11).On Embryo Gallus domesticus, influenza virus there is inhibitory action, better with 70% pure preserved material effect.

Radix Pseudostellariae has invigorating qi and benefiting blood, promotes the production of body fluid, the effect of tonifying the spleen and stomach.Be suitable for children's's summer heat of a specified duration do not move back, weak after being ill unable, the spontaneous perspiration of the disease of weaknesses such as diet is depressed, the deficiency of the lung, cough, cardiopalmus and children's, night sweat, mouthful equality disease.Deficiency of the lung cough caused by dryness that is used for hindering in deficiency of vital energy Tianjin and cardiopalmus sleeplessness, deficiency-heat hyperhidrosis.Can supplementing QI for promoting the production of body fluid.Control deficiency of vital energy xeropulmonary cough, join Radix Glehniae, Radix Ophiopogonis etc., control cardiopalmus sleeplessness, the hyperhidrosis of deficiency of both QI and YIN, complex acid Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis etc.But the power that its QI invigorating tonifying YIN promotes the production of body fluid all is weaker than Radix Panacis Quinquefolii.. " book on Chinese herbal medicine is new again ": control the deficiency of vital energy dryness of the lung, spleen reinforcing soil, consumer edema reduces phlegm and quenches the thirst.

Fructus Forsythiae is bitter, is slightly cold.Return lung, the heart, small intestine meridian.Function is a heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Be used for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, the hyperpyrexia excessive thirst, coma is sent out speckle, the pyretic stranguria urine retention.The medicinal part of Fructus Forsythiae mainly is a fruit.Its shell, i.e. " sticking up " in " a kind of reed mentioned in ancient books sticks up detoxifying pills ".Contain forsythol, coumarin, oleanolic acid, Saponin, Citrin etc.Have effects such as heat clearing away, detoxifcation, eliminating stagnation evacuation of pus.Cure mainly warm, skin infection, scrofula, erysipelas, class's rash, influenza, be decocted in water for oral dose with fruit, or add in the prescription.Be usually used in anemopyretic cold.Nature,taste and action: Chinese medicine bitter in the mouth, cold nature.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.The mongolian medicine bitter in the mouth, cool in nature." association's day " clearly, antidiarrheal.Cure mainly: Chinese medicine is controlled calentura from the beginning of, anemopyretic cold, and heating is vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, pyretic stranguria.The mongolian medicine subcutaneous ulcer of harnessing the Yellow River, intestinal twinge, " association day " disease, intestinal heat.The Sheng Nong's herbal classic ": main cold and heat, Mus flaccidity, scrofula, carbuncle, malignant boil, goiter, stagnation of pathogenic heat, diseases due to noxious agents produced by various parasites.

The Bombyx Batryticatus expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Control apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble sore throat, scrofula tuberculosis.Wind skin ulcer urticaria, erysipelas, mastitis."The Classic": the main pediatric epilepsy Yeti, go three worms, off black über men overcast ulcer disease." not Lu ": woman's metrorrhagia be red white, puerperal surplus pain, all skin ulcer cicatrixs of going out.

Radix Rehmanniae Preparata, the Chinese medicine name has another name called Radix Rehmanniae Preparata.Concoct through processing for the tuber of scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa (Gdertn) Iibosch.ex Fisch.et Mey.) and to form.Usually be that adjuvant shines through steaming repeatedly with wine, Fructus Amomi, Pericarpium Citri Reticulatae, glossy to inside and outside darkish complexion, the quality softness is sticky.Section usefulness, or parch to black is used.After concocting, the property of medicine is by the commentaries on classics tepor that is slightly cold, the enhancing of tonification property, and " herbal classic is met former ": " Radix Rehmanniae Preparata, false firepower steam and shine, and it is sweet changeing hardship, is the yang aspect of yin, so vigour in the ability the kidney invigorating." generation research, the contained Dihuang polysaccharide of Radix Rehmanniae Preparata has tangible immune antitumor activity, also has significant heart tonifying, diuresis, protects the liver, effects such as blood sugar lowering, anti-hypertrophy, exudation, antiinflammatory, antifungal, anti-radiation.

The manufacturing process of the present invention's honey refining pill is: earlier Radix Pseudostellariae 1000g, Radix Salviae Miltiorrhizae 1000g and Radix Astragali 1000g are added in the ethanol that 5-10 doubly measures, extract 2 times; Heating extraction 1-2 hour, be concentrated into the mass shape; The medicinal residues that will refine again and all the other crude drug Radix Bupleuri 1000g, Fructus Gardeniae 1000g, Fructus Forsythiae 1000g, Radix Rehmanniae Preparata 1000g, Ramulus Cinnamomi 1000g, Fructus Ligustri Lucidi 1000g; Herba Hedyotidis Diffusae 1000g, Radix Ophiopogonis 1000g, Flos Carthami 1000g, Radix Paeoniae Alba 1000g, Radix Notoginseng 1000g; Radix Polygoni Multiflori Preparata 1000g, Poria 1000g, Retinervus Luffae Fructus 1000g, Rhizoma Chuanxiong 1000g, Rhizoma Curcumae 1000g; Radix Scutellariae 1000g, Flos Albiziae 1000g, Bombyx Batryticatus 1000g, Radix Angelicae Sinensis 1000g, Semen Platycladi 1000g; Put into multi-function extractor, in the water that adding 5-10 doubly measures, extract 2 times; Heating extraction 1-2 hour, be concentrated into the mass shape, two kinds of mass Hybrid Heating are dried to fine powder after, call in Mel and process honey refining pill.

Capsule preparation method thereof of the present invention is: get Radix Pseudostellariae 1000g, Radix Salviae Miltiorrhizae 1000g, Radix Astragali 1000g, Radix Bupleuri 1000g, Fructus Gardeniae 1000g, Fructus Forsythiae 1000g, Radix Rehmanniae Preparata 1000g; Ramulus Cinnamomi 1000g, Fructus Ligustri Lucidi 1000g, Herba Hedyotidis Diffusae 1000g, Radix Ophiopogonis 1000g, Flos Carthami 1000g, Radix Paeoniae Alba 1000g; Radix Notoginseng 1000g, Radix Polygoni Multiflori Preparata 1000g, Poria 1200g, Retinervus Luffae Fructus 1000g, Rhizoma Chuanxiong 1200g, Rhizoma Curcumae 1000g; Radix Scutellariae 1000g, Flos Albiziae 1200g, Bombyx Batryticatus 1000g, Radix Angelicae Sinensis 1000g, Semen Platycladi 1000g; The water logging bubble that adding 5-10 doubly measures 1-2 hour extracts 2 times; Heating extraction 1-2 hour, be concentrated into the extractum shape, become component 1; Again medicinal residues are added the 60-90% soak with ethanol 1-2 hour, extract twice, each 0.5-1 hour, merge extractive liquid; Filter, concentrate, the 80-160 order filters, the 6000-10000 rev/min of supernatant after centrifugal; Through the molecular weight that dams is the ultrafiltration post ultrafiltration of 5000-10000,1.38 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating and refluxing extraction 2 times, each 30 minutes～45 minutes; Extract active ingredient, the merging of extracted twice liquid is settled into the extractum shape, as component 2; Adding the ethanol thickening filtration is the extractum shape, is component 2; Component 2 extractum are pulverized mixing, and the adding dextrin is an amount of, puts into the hothouse drying, and hot stream temperature is 80 ℃-100 ℃, gets raw material medicated powder, incapsulates patent medicine.

The method for preparing of tablet of the present invention: add Radix Pseudostellariae 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Astragali 1500g, Radix Bupleuri 1500g, Fructus Gardeniae 1300g, Fructus Forsythiae 1500g, Radix Rehmanniae Preparata 1500g; Ramulus Cinnamomi 1200g, Fructus Ligustri Lucidi 1500g, Herba Hedyotidis Diffusae 1500g, Radix Ophiopogonis 1500g, Flos Carthami 1500g, Radix Paeoniae Alba 1500g; Radix Notoginseng 1500g, Radix Polygoni Multiflori Preparata 1500g, Poria 1000g, Retinervus Luffae Fructus 1500g, Rhizoma Chuanxiong 1500g, Rhizoma Curcumae 1500g; Radix Scutellariae 1500g, Flos Albiziae 1500g, Bombyx Batryticatus 1500g, Radix Angelicae Sinensis 1500g, Semen Platycladi 1500g; Add 10 times of amount ethanol, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, the relative density of filtrating is about 1.08 (20 ℃); Above-mentioned filtrating is the macroporous adsorptive resins of 10L through volume, and with the deionized water or the distilled water eluting of 10 times of resin column volumes, 95% ethanol elution of 5 times of resin column volumes of reuse is collected ethanol elution, removes solvent, obtains the component medicine earlier; Be pressed into tablet with amylodextrin.

The present invention or when short the method for preparing of drop pill may further comprise the steps: according to said component ratio of weight and number with Bombyx Batryticatus 1500g; Rhizoma Curcumae 1300g, Radix Pseudostellariae 1200g and Radix Notoginseng 1200g are with adding the water that 5-7 doubly measures; Put into multi-function extractor; Keep air pressure at 0.04-0.06mPa, decocted 2 hours, extract its water soluble ingredient; Repeat above-mentioned steps and extracted extracting liquid filtering 100 mesh sieves once more 1.5 hours; With the refining filtrating of macroporous adsorbent resin, use ethanol elution; It is 1.33-1.35 that eluent is evaporated to density, and wherein input air pressure is 0.04-0.06mPa, and vacuum is-0.076-0.088mPa stand for standby use; All the other component Radix Salviae Miltiorrhizae 1200g, Radix Astragali 1200g, Radix Bupleuri 1500g, Fructus Gardeniae 1500g, Fructus Forsythiae 1500g; Radix Rehmanniae Preparata 1500g, Ramulus Cinnamomi 1500g, Fructus Ligustri Lucidi 1500g, Herba Hedyotidis Diffusae 1500g, Radix Ophiopogonis 1500g; Flos Carthami 1500g, Radix Paeoniae Alba 1500g, Radix Polygoni Multiflori Preparata 1500g, Poria 1500g, Retinervus Luffae Fructus 1500g; Rhizoma Chuanxiong 1500g, Radix Scutellariae 1500g, Flos Albiziae 1500g, Radix Angelicae Sinensis 1500g, Semen Platycladi 1500g; Add the water that its weight sum 5-7 doubly measures; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours; The filter extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate is to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitation liquid filters with 100 mesh sieves; The use sephadex chromatography is refining, uses ethanol elution; Eluent is concentrated into density 1.33-1.35, leaves standstill; Get above-mentioned two kinds leave standstill drop go into cool off in the dimethicone drop pill.

Drop pill machine technology parameter is following: the drip irrigation temperature keeps 85-95 ℃, and condensed fluid liquid paraffin temperature is lower than 8 ℃, and the water dropper internal diameter is 1.6mm, and the water dropper external diameter is 2.5mm, and water dropper is 15cm apart from the liquid paraffin surface distance; Centrifugal, rotating speed 800-1100rpm after 15 minutes, removes deparaffnize and gets final product.Be quick acting, drop pill of the present invention is made into to dissolve the piller of absorption in the Sublingual rapidly, and it can go into blood fast, through cardiac muscle.

Toxicology test:

Experimental example 1: acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: tablet of the present invention contains 0.0365g crude drug/sheet

Two, method:

1, LD50 calculates: adopt the improvement karber's method, mice is divided into 5 groups at random, and 10 every group, male and female half and half; With the dissolving of tablet adding distil water, be made into Cmax, by the administration of the maximum permission capacity of mice, institute is followed successively by 18 to dosage by the crude drug amount; 14.4,11.5,9.2,7.4 (g.kg-1); In animal fasting (can't help water) after 18 hours, administration at twice (half an hour at interval) in a day, each 0.5ml observes the animal dead situation.

2, maximum tolerated dose is measured (MTD value): get 20 of mices, each 10 of male and female.With tablet adding distil water dissolving, be made into maximum concentration, by the maximum tolerated dose of animal, irritate with injection and to feed device and can twitch and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice (half an hour at interval) in a day, each 0.5ml (every ml contains crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Observed 7 days continuously after the administration.

Three, result of the test:

In LD50 calculates when giving mice (18g/Kg.d) with maximum acceptable concentration and maximum permission capacity; Do not see dead mouse, promptly do not measure LD50, ask maximum tolerated dose only; In 7 day observation period; Its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normally, and not seeing has death.Promptly select 300 times of doses that are equivalent to clinical dosage for use, and have no adverse reaction, show that acute toxicity is minimum, MTD＞18g/Kg.d.

Experimental example 2: aggregate toxicity experiment:

The agent of Chinese medicine preparation of the present invention honey refining for oral administration pill to mice by 7.69,19.18 and the 43.21g crude drug/15 weeks of kg continuous use (1.0ml/100g body weight; Every day 2 times) and after 3 week of drug withdrawal; The result shows: Chinese medicine preparation of the present invention does not all have obvious influence to indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat; The internal organs naked eyes do not find that difference changes and the histological examination result shows; After 15 weeks of medication and 3 weeks of drug withdrawal, each internal organs of rat all do not have obvious change.Explain that toxicity is little after Chinese medicine preparation oral capsule of the present invention is to the rat long-term prescription, also do not have the difference reaction after the drug withdrawal, application safety.

Experimental example 3: anti-CB3 virus result of the test shows in the body: drop pill of the present invention has the significant protection effect to the virogenetic mice viral myocarditis of CB3; Can improve neutralizing antibody concentration in the mice body; Obviously suppress Vero necrocytosis rate; It suppresses percentage rate can reach 400%, and obviously reduces administration group mice serum virus titer.Pathological examination shows that the pathological change of administration group mouse cardiac muscle cell is significantly less than the virus control group, and prompting has therapeutical effect to viral myocarditis.

Experimental example 4: the test of open chest anesthetized cardiac hemodynamics of dogs shows: drop pill of the present invention can obviously reduce arteriotony and total peripheral resistance; Reduce coronary resistance, increase coronary flow; Reduce left indoor pressure, left chamber EDP, ± dp/dtmax; Increase cardiac output, cardiac index and SI; And reduce myocardium coefficient of oxygen utilization and oxygen consumption index.Heart rate and electrocardiogram there is not obvious shadow noon.In sum, this medicine can reduce load before and after the heart, reduces cardiac work, and increases the blood supply of cardiac muscle oxygen supply, reduces myocardial oxygen consumption, though weaken myocardial contraction, does not reduce cardiac output, and the heart of viral myocarditis is had certain protective role.

Experimental example 5: the Acute Myocardial Ischemia in Rats test that anti-isoproterenol brings out shows: the ECG change and the sick experimental example 8 of the Acute Myocardial Ischemia in Rats that drop pill of the present invention can obviously resist isoproterenol to be brought out: the myocardial ischemia test that anti-pituitrin brought out shows: the ECG change of the Acute Myocardial Ischemia in Rats that drop pill of the present invention can obviously resist pituitrin to be brought out.

Therefore; Can think that from results of pharmacodynamic test these article have anti-CB3 virus; Protecting myocardial cell increases the blood supply oxygen supply of cardiac muscle, improves myocardial ischemia and antiarrhythmic effect; Be the medicine of a comparatively ideal treatment viral myocarditis, the result of clinical trial has also further proved its curative effect.

Pharmacological experiment:

Experiment 1: to the influence of mice viral myocarditis

(1) test material

Animal: the Swiss mice, male and female half and half, in age in 3-4 week, 16-18g is provided by Shandong University's medical board Experimental Animal Center.

Medicine: the stem and leaf of Radix Panacis Quinquefolii total saponins, positive control drug is the present invention's honey refining pill.

(2) test method and result

Inoculation contains 10 4 TCID, 50 CVB, 3 liquid 0.2ml through the abdominal cavity with mice, behind the 1h, and gastric infusion, two weeks of successive administration.The virus of model control group mouse inoculation same dose irritates stomach, continuous two weeks for every day the normal saline of same dose.After the last administration, pluck eyeball and get blood, separation of serum is measured myocardium three enzyme glutamic oxaloacetic transaminase, GOT AST, creatine phosphokinase CK, lactate dehydrogenase L DH.The result sees table 2.

The influence of table 2 pair mice viral myocarditis cardiac muscle three enzymes (X ± s)

Annotate: with the virus control group than * p＜0.05, * * p＜0.01

The result shows that drop pill of the present invention can significantly reduce myocardium three enzymes in the myocarditis animal pattern blood, has the effect of treatment viral myocarditis.

Experiment 2: barium chloride is caused the influence of rat ventricular

(1) test material

Medicine: test is with the comfortable cellulose capsule of positive drug, lot number: 941102.Provide by Jilin Province Jian Pharmaceutical Factory.Barium chloride is produced by Kaiyuan chemical reagent factory.Animal: the wistar rat, body weight 200-250g is available from Shandong Province Chinese medicine academy animal housing.

(2) test method and result

Get 45 rats, be divided into five groups at random: model group, comfortable cellulose capsule 140mg/kg dosed administration group, drop pill of the present invention 140,70,35mg/kg dose groups.Every day, gastric infusion twice, and successive administration five days after the last administration 1 hour, in rats by intraperitoneal injection chloral hydrate 300mg/kg anesthesia, is measured normal II lead electrocardiogram.Sublingual vein injection barium chloride 4mg/kg observes electrocardiogram and changes then.Write down that electrocardiogram recovers normal number of animals and arrhythmia persistent period in 20 minutes.The result sees table 2.

Table 2 pair barium chloride causes the influence of rat ventricular

Annotate: with model control group than * p＜0.05

The result shows; Occur arrhythmia electrocardiograms such as tachycardia, ventricular premature contraction behind the rat intravenous injection barium chloride immediately, take animal of the present invention the arrhythmia symptom is eased; Recovering normal number of animals in 20 minutes obviously increases, and has shortened the ARR persistent period.

Experiment 3: isoproterenol is caused the influence of rat heart muscle ischemia

(1) test material

Animal: the wistar rat, body weight 200-250g is available from Shandong Chinese medicine academy animal housing.

Medicine: stem and leaf of Radix Panacis Quinquefolii total saponins; SHENGMAI ZHUSHEYE is produced lot number: 970403 by Pharmacuetical Plant of Huaxi Medical Univ..Isoprenaline Iso injection: produce lot number: 951002 by Shanghai Hefeng Pharmaceutical Co., Ltd..

(2) test method and result

Get 60 rats, be divided into six groups at random: blank group, ischemia model group, SHENGMAI ZHUSHEYE 4.5ml/kg dosed administration group, stem and leaf of Radix Panacis Quinquefolii total saponins 20,10, three dose groups of 5mg/kg.Once a day, the continuous intravenous injection administration is three days.After the last administration 30 minutes, except that the blank group, the equal subcutaneous injection Iso of all the other animals 8mg/kg was administered once after 24 hours again.Preceding 30 minutes of last administration is Iso 2mg/kg of subcutaneous injection again, animal is anaesthetized with chloral hydrate 300mg/kg in 15 minutes after the last administration.The abdomen venous blood collection, separation of serum is measured CK, AST, LDH activity; With the animal sacrificed by decapitation, take out heart rapidly then, the nose part of coring in 10% formalin fixed, is done the pathology inspection; Other chamber muscular tissue of coring in 0-4 ℃ of homogenate, is measured the wherein active and MDA content of SOD.The result sees table 3.

Table 3 pair isoproterenol causes the influence (X ± s) of rats with myocardial ischemia cardiac muscle three enzymes

Annotate: compare with the blank group: * P＜0.05, * * P＜0.01, compare with model group * * * P＜0.001: #P＜0.05, ##P＜0.01, ##P＜0.001

Visible by the result, serum center flesh three enzymes obviously raise after myocardial ischemia appearred in animal, and particularly CK and AST are apparently higher than the blank group.Injection stem and leaf of Radix Panacis Quinquefolii total saponins and SHENGMAI ZHUSHEYE can obviously suppress the rising of CK and AST, and Radix Panacis Quinquefolii saponin also can reduce the activity of LDH, shows tangible function of resisting myocardial ischemia.

Clinical experiment:

Viral myocarditis is a kind of by due to the viral infection being master's disease with myocardium inflammatory disorders.Cause that this disease most commonly encountered diseases poison is the Ke Saji B papova in the enterovirus, other also have multiple viruses such as echovirus, adenovirus, influenza virus, hepatitis virus.Still lack the specific treatment measure at present to this disease, we adopt independent research Chinese medicine preparation treatment caused by hepatic stagnation qi stagnation viral myocarditis 60 examples, and obtain satisfactory effect, and existing report as follows.

1 materials and methods

1.1 physical data

Case (2006-2009) 60 examples are observed in this research, and the standard of drafting with reference to national myocarditis, cardiomyopathy workshop in 1987 is diagnosed as the stagnation of QI due to depression of the liver viral myocarditis.Be divided at random and hinder flesh and rather organize (treatment group) 30 examples, wherein male 17 examples, women 13 examples; 11～42 years old age, average (25 ± 1.4) year; Course of disease 7d～10 month, average (3.2 ± 0.15) individual month.Matched group 30 examples, male 15 examples, women 15 examples; 9～47 years old age, average (25 ± 1.5) year; The course of disease 5～9 months, average (3.2 ± 0.52) individual month.Treatment group and matched group patient all have electrocardiographic abnormality in various degree, are respectively premature beat person's 10,11 examples, arrhythmia person 4,6 examples; Sinus tachycardia person's 3,3 examples; Sinus bradycardia person's 3,4 examples, atrioventricular block person's 7,4 examples, bundle branch block person 3,2 examples.Two groups of physical data have comparability, P＞0.05 no difference of science of statistics through statistical procedures at aspects such as sex, age, the courses of disease.

Chinese medical discrimination is with reference to the myocarditic clinical research guideline of stagnation of QI due to depression of the liver property of Ministry of Public Health formulation in 1993; For evil poison is invaded the heart, syndrome of deficiency of both qi and yin.Mainly show as vexed uncomfortable in chest, cardiopalmus, uncomfortable in chest or chest pain, shortness of breath and fatigue, spontaneous perspiration or night sweat, big dry stool, red urine, red tip of the tongue, yellow fur, is counted accurately unable or slow or knot, generation, short at the swift pulse number.

1.2 Therapeutic Method

Two groups of patients all avoid exertion, and prevent to suffer from cold, and take a good rest.All give conventional western medical treatment: the western medical treatment method: (1) oxygen uptake; (2) control liquid measure; (3) control infection is used corresponding antibiotic and antiviral therapy according to nosetiology.Can use dexamethasone during heart failure, use digoxin control heart failure etc.Large doses of vitamin C, 1,6-fructose diphosphate, coenzyme Q10 and symptomatic treatment.Correct severe arrhythmia.The treatment prescription is used Radix Bupleuri 10g, Fructus Gardeniae 15g, Fructus Forsythiae 10g, Radix Pseudostellariae 10g, Radix Rehmanniae Preparata 10g, Ramulus Cinnamomi 15g, Fructus Ligustri Lucidi 15g; Herba Hedyotidis Diffusae 10g, Radix Ophiopogonis 10g, Radix Salviae Miltiorrhizae 10g, Flos Carthami 15g, Radix Paeoniae Alba 10g, Radix Notoginseng 10g, Radix Astragali 15g; Radix Polygoni Multiflori Preparata 15g, Poria 10g, Retinervus Luffae Fructus 10g, Rhizoma Chuanxiong 10g, Rhizoma Curcumae 15g, Radix Scutellariae 10g; Flos Albiziae 10g, Bombyx Batryticatus 10g, Radix Angelicae Sinensis 15g, Semen Platycladi 10g: process granule by Chinese medicine preparation research and development centre of this institute, each 5g, every day 3 times.1 month course of treatment, there is complication person to give anti symptom treatment.

1.3 observation of curative effect

Symptom and sign: cardiopalmus, uncomfortable in chest, chest pain, breathe hard and symptom such as weak; Signs such as heart rate, the rhythm of the heart, die Blausucht, pulmonary's sound.

Lab index: virucidin measures.

1.4 curative effect determinate standard

Curative effect determinate standard by ministry of Health of China " the clinical research guideline of new Chinese medicine treatment viral myocarditis " in 1993 formulation.Recovery from illness: clinical symptoms, sign disappear, and it is normal that viral coherent detection index is recovered; Produce effects: clinical symptoms, sign disappear basically, and viral coherent detection index recovers normal basically; Effectively: clinical symptoms, sign make moderate progress, and viral coherent detection index has certain improvement; Invalid: clinical symptoms, sign and viral coherent detection index all do not have improvement.

1.5 statistical method

Different according to observation index, enumeration data adopts χ ²Check, P＜0.01; Or P＜0.05; Or 0.01＜P＜0.05 shows that remarkable statistical significance is arranged, and P＞0.05 shows not to be had significantly

Statistical significance, application software X 2 test computer V1.61 statistical analysis.

2 results

2.1 the evaluation of clinical efficacy

Can find out from table 1, two groups of clinical efficacies, treatment group cure-remarkable-effectiveness rate is 86.67%, total effective rate is 96.67%; The matched group cure-remarkable-effectiveness rate is 36.67%, and total effective rate is 60.00%, and difference has significance meaning (P＜0.01).

Table 1 liang group clinical efficacy is [example (%)] relatively

Annotate: the treatment group is compared significant difference with matched group, χ ²=11.67, * P＜0.01

2.2 The main symptoms is improved and is estimated

Can find out that from table 2 two groups of each symptoms all have improvement in various degree, treatment group cardiopalmus, uncomfortable in chest, chest pain, breathe hard and weak doing well,improving obviously is superior to matched group.

Table 2 liang group cardinal symptom and efficacy result be (example) relatively

Annotate: the treatment group is compared significant difference with matched group, * * P＜0.01, * P＜0.05 or 0.01＜P＜0.05

Primary disease diseases caused by exogenous pathogenic factor person is in the majority with wind heat, and heat is YANG pathogen, is prone to impairment of body fluid consumption gas, so supplementing QI and nourishing YIN is treatment primary disease rule of treatment.Result of study demonstration Chinese medicine therapy can fundamentally be adjusted myocarditis patient body complex immunological state, can obviously reduce too high Immunoglobulin IgA, IgG, eliminates antimyocardial antibody, free radical; Through clearing away phlegm, collateral dredging, removing blood stasis with potent drugs; Can suppress to decompose the myocardial fibrosis tissue, and have and obviously prevent myocardial remodelling, prevent that myocarditis is converted into the dilated cardiomyopathy effect; Anti-recurrence is worth clinical application.

Specific embodiment 1: the river, the man 55 years old, because of having palpitation, breathe hard 1d, increases the weight of 4h, in June, 2008.The rabat prompting: left ventricle enlarges; Electrocardiogram dynamic monitoring inspection: myocardial strain; Take place frequently the chamber early; Arrhythmia.Be diagnosed as " viral myocarditis ".Patient's sensation of oppression over the chest with shortness of breath, dry mouth with bitter taste, pale tongue with white fur is hard and dry, and vexed gas is hot-tempered, deep-thready pulse.Chinese medical discrimination is a deficiency of both QI and YIN.Control with supplementing QI and nourishing YIN, nourishing yin and promoting blood circulation, the side uses Radix Bupleuri 15g, Fructus Gardeniae 15g, Fructus Forsythiae 10g, Radix Pseudostellariae 10g, Radix Rehmanniae Preparata 10g; Ramulus Cinnamomi 15g, Fructus Ligustri Lucidi 10g, Herba Hedyotidis Diffusae 10g, Radix Ophiopogonis 10g, Radix Salviae Miltiorrhizae 10g, Flos Carthami 15g; Radix Paeoniae Alba 10g, Radix Notoginseng 10g, Radix Astragali 15g, Radix Polygoni Multiflori Preparata 10g, Poria 10g; Retinervus Luffae Fructus 10g, Rhizoma Chuanxiong 10g, Rhizoma Curcumae 15g, Radix Scutellariae 15g, Flos Albiziae 10g; Bombyx Batryticatus 10g, Radix Angelicae Sinensis 15g, Semen Platycladi 10g: plus-minus is equipped with 10% glucose injection 250mL and adds SHENGMAI ZHUSHEYE 30mL intravenous drip, 1 time on the 1st.Nursing is basis with psychology and living nursing, through more than 20 day treatment by Chinese herbs and traditional Chinese medical science holistic Nursing, transference cure, use again pill of the present invention after one month the electrocardiogram recovery normally, recovered and discharged.。

Specific embodiment 2: poplar, the woman, 18 years old, sufferer had the hepatitis history, and irritability, like sulky, the personality haze, cardiopalmus takes place frequently; My institute checks that disease is seen severe palpitation, does during cardiopalmus, and is vexed uncomfortable in chest in March, 2009, insomnia and dreamful sleep, and bitter taste in the mouth and dry throat, constipation is dizzy, sensation of oppression over the chest with shortness of breath; Spiritlessness and weakness, spontaneous perspiration or night sweat, red tip of the tongue, thin fur, stringy and rolling pulse or short type of deficiency of both the heart and spleen, when disease is seen cardiopalmus, shortness of breath and fatigue, uncomfortable in chest; Feel dizzy, insomnia and dreamful sleep, indigestion and loss of appetite spontaneous perspiration, pale tongue, white and thin fur, thready pulse or knot, generation, control with supplementing QI and nourishing YIN, nourishing yin and promoting blood circulation, the side uses Radix Bupleuri 15g; Fructus Gardeniae 15g, Fructus Forsythiae 10g, Radix Pseudostellariae 10g, Radix Rehmanniae Preparata 10g, Ramulus Cinnamomi 15g, Fructus Ligustri Lucidi 10g, Herba Hedyotidis Diffusae 10g; Radix Ophiopogonis 10g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 15g, Radix Paeoniae Alba 10g, Radix Notoginseng 15g, Radix Astragali 15g, Radix Polygoni Multiflori Preparata 10g; Poria 10g, Retinervus Luffae Fructus 15g, Rhizoma Chuanxiong 10g, Rhizoma Curcumae 15g, Radix Scutellariae 15g, Flos Albiziae 10g, Bombyx Batryticatus 10g; Radix Angelicae Sinensis 15g, Semen Platycladi 15g: through one month treatment, the state of an illness was stablized with becoming, but slight cardiac dilatation is arranged, aroused in interestly can go down, arrhythmia or electrocardiogram change, through 3 months treatment, any Sx was not left in patient's recovery from illness.

Specific embodiment 3: go into business certain, the man, 21 years old, irritability like to be got angry at ordinary times, liked eating peppery, was fond of drinking and ate barbecue, and insomnia is irritated; Come my institute's inspection, do when disease is seen cardiopalmus, vexed uncomfortable in chest, insomnia and dreamful sleep; Bitter taste in the mouth and dry throat, constipation, yellowish or reddish urine, liver-fire expectorant heat; Red tongue, yellow and greasy fur, stringy and rolling pulse or short, auxiliary examination: numeration of leukocyte raises; Electrocardiographic abnormality, myocardial damage ST-T changes, and is diagnosed as viral myocarditis after the diagnosis.The patient is cut out Western medicine, change Chinese traditional treatment, the side uses: the side uses Radix Bupleuri 15g, Fructus Gardeniae 15g, Fructus Forsythiae 10g, Radix Pseudostellariae 10g; Radix Rehmanniae Preparata 10g, Ramulus Cinnamomi 15g, Fructus Ligustri Lucidi 10g, Herba Hedyotidis Diffusae 10g, Radix Ophiopogonis 10g, Radix Salviae Miltiorrhizae 15g; Flos Carthami 15g, Radix Paeoniae Alba 10g, Radix Notoginseng 15g, Radix Astragali 15g, Radix Polygoni Multiflori Preparata 10g, Poria 10g; Retinervus Luffae Fructus 15g, Rhizoma Chuanxiong 10g, Rhizoma Curcumae 15g, Radix Scutellariae 15g, Flos Albiziae 10g, Bombyx Batryticatus 10g; Radix Angelicae Sinensis 15g, Semen Platycladi 15g takes the medicine pill according to the present invention, takes every day three times, and each 3 balls give conventional to lie up when the viral myocarditis acute attack, oxygen uptake, Energy mixture; Nursing is basis with psychology and living nursing, through more than 30 day treatment by Chinese herbs and traditional Chinese medical science holistic Nursing, transference cure, use again pill of the present invention after 2 months the electrocardiogram recovery normally, recovered and discharged.Follow up a case by regular visits to and do not have recurrence.

Claims

1. a Chinese medicine preparation of treating the caused by hepatic stagnation qi stagnation viral myocarditis is characterized in that, the ratio of weight and number of various crude drug is in the said Chinese medicine preparation: 10～20 parts of Radix Bupleuri, 10～20 parts of Fructus Gardeniaes, 10～20 parts of Fructus Forsythiaes; 10～20 parts of Radix Pseudostellariaes, 10～20 parts of Radix Rehmanniae Preparata, 10～20 parts of Ramulus Cinnamomi, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Herba Hedyotidis Diffusaes; 10～20 parts of Radix Ophiopogonis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts on Flos Carthami, 10～20 parts of the Radix Paeoniae Albas; 10～20 parts of Radix Notoginseng, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts in Poria; 10～20 parts of Retinervus Luffae Fructuss, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Scutellariaes; 10～20 parts of Flos Albiziaes, 10～20 parts of Bombyx Batryticatus, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Semen Platycladi.

2. according to the Chinese medicine preparation of the said treatment caused by hepatic stagnation qi stagnation of claim 1 viral myocarditis, it is characterized in that the ratio of weight and number of various crude drug is in the said Chinese medicine preparation: 10～15 parts of Radix Bupleuri, 10～15 parts of Fructus Gardeniaes, 10～15 parts of Fructus Forsythiaes; 10～15 parts of Radix Pseudostellariaes, 10～15 parts of Radix Rehmanniae Preparata, 10～15 parts of Ramulus Cinnamomi, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Herba Hedyotidis Diffusaes; 10～15 parts of Radix Ophiopogonis, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts on Flos Carthami, 10～15 parts of the Radix Paeoniae Albas; 10～20 parts of Radix Notoginseng, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts in Poria; 10～20 parts of Retinervus Luffae Fructuss, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Scutellariaes; 10～20 parts of Flos Albiziaes, 10～20 parts of Bombyx Batryticatus, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Semen Platycladi.

3. according to the Chinese medicine preparation of the said treatment caused by hepatic stagnation qi stagnation of claim 1 viral myocarditis, it is characterized in that the ratio of weight and number of various crude drug is in the said Chinese medicine preparation: 10～20 parts of Radix Bupleuri, 10～20 parts of Fructus Gardeniaes, 10～20 parts of Fructus Forsythiaes; 10～20 parts of Radix Pseudostellariaes, 10～20 parts of Radix Rehmanniae Preparata, 10～20 parts of Ramulus Cinnamomi, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Herba Hedyotidis Diffusaes; 10～20 parts of Radix Ophiopogonis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts on Flos Carthami, 10～20 parts of the Radix Paeoniae Albas; 10～15 parts of Radix Notoginseng, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～15 parts in Poria; 10～15 parts of Retinervus Luffae Fructuss, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Rhizoma Curcumae, 10～15 parts of Radix Scutellariaes; 10～15 parts of Flos Albiziaes, 10～15 parts of Bombyx Batryticatus, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Semen Platycladi.

4. the method for preparing like the Chinese medicine preparation of each said treatment caused by hepatic stagnation qi stagnation viral myocarditis in the claim 1～3 is characterized in that, said Chinese medicine preparation dosage form is a honey refining pill, and its preparation process is:

A. earlier Radix Pseudostellariae, Radix Salviae Miltiorrhizae and the Radix Astragali are refined with ethanol;

The medicinal residues that b. will refine are again put into the multi-function extractor extracting in water with all the other crude drug;

C. then with extracted twice thing combination drying powdering, add Mel and be twisted into pill.

5. according to the said method for preparing of claim 4, it is characterized in that, among the said step a, get Radix Pseudostellariae, Radix Salviae Miltiorrhizae and the Radix Astragali and add in the ethanol that its weight portion 5-10 doubly measures, extract 2 times; Heating extraction 1-2 hour, be concentrated into the mass shape.

6. according to the said method for preparing of claim 4, it is characterized in that, among the said step b, the medicinal residues that refined and all the other crude drug are put into multi-function extractor, in the water that adding 5-10 doubly measures, extract 2 times; Heating extraction 1-2 hour, be concentrated into the mass shape.

7. the method for preparing like the Chinese medicine preparation of each said treatment caused by hepatic stagnation qi stagnation viral myocarditis in the claim 1～3 is characterized in that the dosage form of said medicine is a drop pill, and its preparation process comprises:

A. earlier with Bombyx Batryticatus, Rhizoma Curcumae, Rhizoma Chuanxiong and Radix Notoginseng are extracted; Adsorb subsequent use;

B. again all the other components being put into water extracts; Sedimentation and filtration leaves standstill;

C. get above-mentioned two kinds leave standstill drop go into cool off in the dimethicone drop pill.

8. according to the said method for preparing of claim 7, it is characterized in that, among the said step a; According to said component ratio of weight and number; With Bombyx Batryticatus, Rhizoma Curcumae, Rhizoma Chuanxiong and Radix Notoginseng add the water that its weight sum 5-7 doubly measures, and put into multi-function extractor; Keep air pressure to decoct 2 hours, extract its water soluble ingredient at 0.04-0.06mPa; Extracting liquid filtering 100 mesh sieves; With the refining filtrating of adsorbent resin back ethanol elution; Eluent is evaporated to density 1.33-1.35, and wherein input air pressure is 0.04-0.06mPa, and vacuum is-0.076 ~-0.088mPa, stand for standby use.

9. according to the said method for preparing of claim 7, it is characterized in that, among the said step b, again all the other components are added the water that its weight sum 5-7 doubly measures; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours; The filter extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate is to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitation liquid filters with 100 mesh sieves; The use sephadex chromatography is refining, uses ethanol elution; Eluent is concentrated into density 1.33-1.35, leaves standstill.

10. according to the Chinese medicine preparation of the said treatment caused by hepatic stagnation qi stagnation of claim 1～3 viral myocarditis; It is characterized in that its dosage form is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, drop pill or extractum.