CN1182858C - Heart-nourishing tea capsule and its prepn - Google Patents
Heart-nourishing tea capsule and its prepn Download PDFInfo
- Publication number
- CN1182858C CN1182858C CNB02133904XA CN02133904A CN1182858C CN 1182858 C CN1182858 C CN 1182858C CN B02133904X A CNB02133904X A CN B02133904XA CN 02133904 A CN02133904 A CN 02133904A CN 1182858 C CN1182858 C CN 1182858C
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- liquid
- water
- heart
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
The present invention relates to a heart-nourishing tea capsule and a preparing method thereof. The preparing method is characterized in that 0.5 to 10 parts of American ginseng is pulverized into fine granules; water or alcohol in any proportion with the water is used as a solvent, five times of extracting are carried out at a back flow temperature, and each time lasts for two hours; the thin-layer chromatography is used for controlling an extracting end point; extracted liquid is merged, refrigerated and filtrated, and the filtrated liquid is concentrated into a thick paste form; pure water is added for uniform mix, refrigeration, filtration and standby; 2 to 30 parts of red sage root, 0.5 to 10 parts of liquorice root and 2 to 30 parts of achyranthes root are cut into slices to be mixed with 1 to 20 parts of lilyturf root and 0.5 to 10 parts of schisandra; the mixture is decocted for three times by adding water, the first time lasts for two hours, and the second time and the third time respectively last for 1 hour for decoction. Decocted liquid is merged and filtrated, and the pH value of the filtered liquid is adjusted to be 5 to 8. The decocted liquid is merged with the spare liquid of the American ginseng, and is eluted by the pure water until the effluent liquid is close to be colorless by a processed adsorbing column of macroporous resin. Then the ethanol is used for elution until the effluent liquid is close to be colorless, and the alcohol eluent is collected. The recovered solvent is distillated by pressure reduction, and is concentrated into the thick paste form. The recovered solvent in the thick paste form is dried in vacuum, ground, granulated and filled into capsules.
Description
One, technical field
The present invention relates to a kind of heart-nourishing tea capsule and preparation method thereof, nourish heart tea to deficiency of qi and yin, caused by energy stagnation and blood stasis breast expand, pained all diseases have health care and therapeutical effect, belong to Chinese medicine preparation.
Two, background technology
Chinese patent 95104818.X has reported a kind of " tea nourishes heart ", and it is to be raw material with six kinds of Chinese medicines such as Arillus Longan, Semen Ziziphi Spinosae and Poria, is equipped with that black tea is refining to form.Chinese patent 95100960.5 is entitled as " " Lanhuai " tea for nourishing heart ", has reported based on the preparation of five Chinese medicines such as Herb Gynostemmae Pentaphylli, Flos Sophorae, has activating blood circulation, the general tea of bag bubble of the heart and lengthening health care that nourishes blood.The situation of existing like product sees table 1 for details.The problem of product existence now is to fill a prescription comprehensive and the fabricating technology backwardness:
1, prescription is not comprehensive
The prescription of existing product biases toward blood circulation promoting and blood stasis dispelling, perhaps lays particular stress on QI invigorating (as giving birth to the pulse agent), can not play diseases such as coronary heart disease, coronary vasodilator blood supply insufficiency, angina pectoris are carried out the effect of QI invigorating and blood circulation promoting and blood stasis dispelling balance therapy.The present invention has balance and Comprehensive Treatment effect with QI invigorating and activating blood and removing stasis drug reasonable compatibility to above disease.
2, preparation technology falls behind
Existing like product all adopts traditional Chinese medicinal preparation method to make, and fabricating technology falls behind, and invalid removal of impurity is low, and total extractum recovery rate is up to more than 10%; Effective component content is low, and the extractum moisture absorption is strong, and preparation stability is poor; Each dose is big.The present invention uses the Debulk technology to remove invalid component to greatest extent, the smart active component that proposes, and total extractum amount has improved preparation stability greatly below 2%, has reduced each dose.
Three, summary of the invention
The objective of the invention is provides a kind of heart-nourishing tea capsule and preparation method thereof at the deficiencies in the prior art, be characterized in adopting the method for QI invigorating medicine and activating blood and removing stasis drug compatibility, form the new recipe that coronary heart disease, coronary vasodilator blood supply insufficiency, angina pectoris is had health care and therapeutical effect.This prescription than the compatibility of existing similar prescription more comprehensively, more reasonable, clinical efficacy is better.
Purpose of the present invention is realized that by following technical measures the prescription umber of wherein said heart-nourishing tea capsule is parts by weight except that specified otherwise.
The prescription component of heart-nourishing tea capsule is:
0.5~10 part in 2~30 portions of Radix Glycyrrhizaes of Radix Salviae Miltiorrhizae
0.5~10 part of 0.5~10 part of Fructus Schisandrae Chinensis of Radix Panacis Quinquefolii
Radix Ophiopogonis, 1~20 part of Radix Achyranthis Bidentatae was 2~30 parts
The preparation method of heart-nourishing tea capsule:
1, Radix Panacis Quinquefolii is ground into particulate for 0.5~10 part, water or with the alcohol of water arbitrary proportion be solvent, extract 5 times down in reflux temperature, each 2 hours, extract terminal point with thin layer chromatography control, merge extractive liquid,, cold preservation, filtration, filtrate are concentrated into paste, add pure water, stir evenly, cold preservation, filtration, standby;
(2) with 2~30 parts of Radix Salviae Miltiorrhizaes, 0.5~10 part in Radix Glycyrrhizae, Radix Achyranthis Bidentatae is cut into slices for 2~30 parts, with 1~20 part of Radix Ophiopogonis, 0.5~10 part of mixing of Fructus Schisandrae Chinensis, decoct with water 3 times, 2 hours for the first time, second, respectively decocted for three times 1 hour, collecting decoction, filter, filtrate is regulated pH=5~8, merges with above-mentioned Radix Panacis Quinquefolii reserve liquid, by the macroporous resin adsorption post of handling well, it is closely colourless to be eluted to effluent with pure water, it is closely colourless to effluent with ethanol elution to continue, and collects alcohol eluen, vacuum distillation recovered solvent, and be concentrated into thick paste shape, vacuum drying, pulverize, granulate, dress up capsule.
The present invention has following advantage:
1, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae blood circulation promoting and blood stasis dispelling in the present invention's prescription, Radix Panacis Quinquefolii strongly invigorating primordial QI, YIN nourishing and the production of body fluid promoting; Calm the nerves in Radix Ophiopogonis, Fructus Schisandrae Chinensis benefit Tianjin; Radix Glycyrrhizae invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription, compatibility can play the effect of supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling comprehensively.The health care and the therapeutical effect that the coronary heart disease of deficiency of both qi and yin blood stasis, angina pectoris, hypertension etc. are had highly significant.
2, preparation process has adopted the Debulk advanced technology, has improved product quality greatly.
3, pharmacological experiments
(1) to the therapeutical effect of myocardial ischemia
Nourish heart tea 0.5,0.15 and 0.45g/kg single gastric infusion, it is right to increase the conscious mouse cardiac muscle
86The intake of rubidium increases the myocardial nutritional flow amount, compares with the blank group, and effect low, middle dosage all has significant difference (p<0.05).
The continuous gastric infusion of tea 0.5,0.15 and 0.45g/kg 7 days nourishes heart, can reduce the anesthetized rat ST section that pituitrin brings out and the ischemic change of T ripple, reduce myocardial ischemia animal incidence rate, compare with the blank group, middle and high dosage group has significant difference (p<0.05).
(2) to Immune Effects
The continuous gastric infusion of the tea that nourishes heart 7 days can obviously increase the phagocytic index and the phagocytic percentage (p<0.05 or p<0.01) of normal mouse peritoneal macrophage, and middle and high dosage can obviously increase normal mouse spleen nk cell activity (p<0.05).The middle and high dosage of the tea that nourishes heart can obviously increase immunocompromised Turnover of Mouse Peritoneal Macrophages phagocytic index and phagocytic percentage (p<0.05 or p<0.01); Simultaneously, can obviously increase immunocompromised mouse spleen NK cytoactive (p<0.05 or p<0.01).
The continuous gastric infusion of the tea that nourishes heart 7 days, high dose can obviously strengthen the specific cellular immunity function of normal and immunocompromised mice, increase delayed hypersensitivity intensity (p<0.05).
(3) improve hypoxia-bearing capability and muscle power
The continuous gastric infusion of the tea that nourishes heart 3 days all can obviously improve mice normal pressure hypoxia-bearing capability, prolong the animals survived time (p<0.05); Low dosage can obviously improve mice decompression anoxia ability, prolongs the time-to-live (p<0.05) of mice.The continuous gastric infusion of the tea that nourishes heart 5 days can increase muscle power, prolongs the mice swimming with a load attached to the body time, has certain antifatigue effect.
(4) blood fat reducing
Adopt the nursing method to set up hyperlipemia rabbit and rat model, nourish heart 6 weeks of tea successive administration, low dosage can obviously reduce hyperlipidemia rabbit TG (p<0.05), and high dose can obviously increase the ratio (p<0.05) of anti-" atherogenic index " HDL/TC; Nourish heart 2 weeks of tea successive administration, low dosage can obviously reduce hyperlipemia rat TG (p<0.05); In 4 weeks of successive administration, can obviously the raise ratio (p<0.05 or p<0.01) of anti-" atherogenic index " HDL/TC of middle and high dosage reduces TC (p<0.05), slightly reduces LDL; The high dose HDL that obviously raises
(p<0.01)。
(5) trial production result in
Carry out pilot scale according to above preparation technology, the extractum yield is about 2%, and active constituent content surpasses 0.6%, and it is stable to make end product quality, and each dose is 1 capsules.
Four, description of drawings
Fig. 1 is the process chart of heart-nourishing tea capsule preparation.
Five, the specific embodiment
Below by embodiment the present invention is specifically described; be necessary to be pointed out that at this present embodiment only is used for the present invention is further specified; can not be interpreted as limiting the scope of the invention, the person skilled in the art in this field can make some nonessential improvement and adjustment according to the content of the invention described above.
1, embodiment is in prescription compatibility of medicines amount every day, makes 2 capsules results by the Debulk technology and sees table 2 for details.
Table 2 is embodiment 1~3 recipe ingredient
Radix Salviae Miltiorrhizae Radix Panacis Quinquefolii Radix Glycyrrhizae Radix Ophiopogonis Fructus Schisandrae Chinensis Radix Achyranthis Bidentatae
Numbering
g g g g g g
1 4 2 5 1 1 17
2 6 0.5 2.5 1 5 15
3 5 2 12 5.5 3.5 2
2, the compatibility according to embodiment 3 enlarges 3 batches, carries out pilot scale, and its result sees table 3 for details.
Table 3 is the pilot-scale experiment of embodiment 3
Inventory extractum amount content of ginsenoside %
Lot number
(kg) (g) Rg Re
20011218 100 2010.12 0.46 0.27
20011220 100 2108.01 0.45 0.18
20011222 100 2005.37 0.45 0.28
3, existing like product state sees table 1 for details.
Table 1 and the similar Chinese medicinal formulae of heart-nourishing tea capsule curative effect
Title | Prescription is formed | Dosage form | Effect | Range of application |
FUFANG DANSHEN PIAN, drop pill | Radix Salviae Miltiorrhizae, Radix Notoginseng, Borneolum Syntheticum | The tablet drop pill | Blood circulation promoting and blood stasis dispelling, fragrance are opened and are stolen, collateral dredging ends logical | The thoracic obstruction due to the resistance of the heart arteries and veins stasis of blood, the coagulation of QI-blood, pained.The coronary heart disease of doctor trained in Western medicine belongs to qi depression to blood stasis person |
Radix Salviae Miltiorrhizae Injection | Radix Salviae Miltiorrhizae | Injection | Blood circulation promoting and blood stasis dispelling | The coronary heart disease of doctor trained in Western medicine, coronary vasodilator blood supply insufficiency, angina pectoris |
FUFANG DANSHEN ZHUSHEYE | Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae | Injection | The clots absorbing pain relieving | The coronary heart disease of doctor trained in Western medicine, coronary insufficiency, myocardial infarction, angina pectoris |
DANQI PIAN | Radix Salviae Miltiorrhizae, Radix Notoginseng | Tablet | Promoting blood circulation to disperse blood clots and relieves pain | The angina pectoris of doctor trained in Western medicine belongs to syndrome of blood stasis person |
Give birth to the pulse agent | Radix Codonopsis, Radix Ophiopogonis, Fructus Schisandrae Chinensis | Electuary | Tonification gas the moon, multiple arteries and veins take off admittedly | Cardiopalmus |
Only holy blood circulation promoting slice | Radix Notoginseng, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Glycyrrhizae | Tablet | Promoting blood circulation and stopping pain | Coronary heart disease |
SHIXIAO SAN | Pollen Typhae, Oletum Trogopterori | Powder | Promoting blood circulation, removing blood stasis and relieving pain | Coronary heart disease belongs to syndrome of blood stasis person |
Yufeng ningxin tablets, yufeng ningxin pian | Radix Puerariae (Radix Puerariae total flavones) | Tablet | Coronary blood flow increasing | Angina pectoris |
The Yixintong sheet | Folium Crataegi (total flavones) | Tablet | Blood circulation promoting and blood stasis dispelling, the easypro network of regulating the flow of vital energy | Angina pectoris |
Claims (2)
1, a kind of heart-nourishing tea capsule is characterized in that it is to be made by the raw material of following weight parts:
0.5~10 part in 2~30 portions of Radix Glycyrrhizaes of Radix Salviae Miltiorrhizae
0.5~10 part of 0.5~10 part of Fructus Schisandrae Chinensis of Radix Panacis Quinquefolii
Radix Ophiopogonis, 1~20 part of Radix Achyranthis Bidentatae was 2~30 parts.
2, according to the preparation method of the described heart-nourishing tea capsule of claim 1, it is characterized in that:
(1) Radix Panacis Quinquefolii is ground into particulate for 0.5~10 part, water or with the alcohol of water arbitrary proportion be solvent, extract 5 times down in reflux temperature, each 2 hours, extract terminal point with thin layer chromatography control, merge extractive liquid,, cold preservation, filtration, filtrate are concentrated into the thick paste shape, add pure water, stir evenly, cold preservation, filtration, standby;
(2) with 2~30 parts of Radix Salviae Miltiorrhizaes, 0.5~10 part in Radix Glycyrrhizae, Radix Achyranthis Bidentatae is cut into slices for 2~30 parts, with 1~20 part of Radix Ophiopogonis, 0.5~10 part of mixing of Fructus Schisandrae Chinensis, decoct with water 3 times, 2 hours for the first time, second, respectively decocted for three times 1 hour, collecting decoction, filter, filtrate is regulated pH=5~8, merges with above-mentioned Radix Panacis Quinquefolii reserve liquid, by the macroporous resin adsorption post of handling well, it is closely colourless to be eluted to effluent with pure water, it is closely colourless to effluent with ethanol elution to continue, and collects alcohol eluen, vacuum distillation recovered solvent, and be concentrated into thick paste shape, vacuum drying, pulverize, granulate, dress up capsule.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB02133904XA CN1182858C (en) | 2002-10-14 | 2002-10-14 | Heart-nourishing tea capsule and its prepn |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB02133904XA CN1182858C (en) | 2002-10-14 | 2002-10-14 | Heart-nourishing tea capsule and its prepn |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1403137A CN1403137A (en) | 2003-03-19 |
CN1182858C true CN1182858C (en) | 2005-01-05 |
Family
ID=4747458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB02133904XA Expired - Fee Related CN1182858C (en) | 2002-10-14 | 2002-10-14 | Heart-nourishing tea capsule and its prepn |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1182858C (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1483283A4 (en) | 2002-03-13 | 2007-04-11 | Signum Biosciences Inc | Modulation of protein methylation and phosphoprotein phosphate |
US8221804B2 (en) | 2005-02-03 | 2012-07-17 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
CN101878832A (en) * | 2010-06-09 | 2010-11-10 | 王武江 | Tea capsule |
CN102771603B (en) * | 2012-07-30 | 2013-08-28 | 昆明理工大学 | Red rhodobryum heart nourishing tea and preparation method thereof |
CN107041445A (en) * | 2017-06-19 | 2017-08-15 | 黎金莲 | A kind of bamboo juice leaf of bamboo health protection tea for preventing and treating hypertension, hyperglycemia |
-
2002
- 2002-10-14 CN CNB02133904XA patent/CN1182858C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1403137A (en) | 2003-03-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103705596B (en) | A kind of Chinese hypotensor and preparation method thereof | |
CN102475830B (en) | Medicinal composition for treating coronary disease and angina pectoris, preparation method thereof and preparation thereof | |
CN103386022A (en) | Chinese medicine composition for treating tuberculous pleurisy | |
CN101856405B (en) | Medicinal composition for treating type II diabetes mellitus and preparation method thereof | |
CN1182858C (en) | Heart-nourishing tea capsule and its prepn | |
CN1785391A (en) | Chinese medicinal composition and its preparation method | |
CN1695730A (en) | Combination of Chinese traditional medicine for treating hyperlipemia, and preparation method | |
CN1267086C (en) | Medicine for treating diabetes and adjusting blood sugar concentration and its preparation | |
CN100428942C (en) | Heart-nourishing and tranquilizing medicine and its prepn process | |
CN1202847C (en) | Diabetes treating medicine | |
CN1242767C (en) | Chinese medicinal compound preparation for treating liver fibrillation disease and its preparation method | |
CN1319578C (en) | Prescription of Chinese medicine compound preparation, its preparation method and use | |
CN111000969A (en) | Pharmaceutical composition for treating simple obesity and preparation method thereof | |
CN1899574A (en) | Chinese medicine composition for preventing and controlling liver cancer and its use | |
CN1814125A (en) | Rehmannia-root preparation | |
CN1559523A (en) | Naodesheng soft capsule and its preparation method | |
CN1943755A (en) | A Chinese traditional medicinal composition for treatment of hypertension and its preparation method | |
CN1695639A (en) | Chinese traditional medicine for treating dysmenorrhea and irregular menses, and preparation method | |
CN1768803A (en) | Medicine for treating hypertension and its preparing process | |
CN113101330B (en) | Menstruation regulating composition and application thereof | |
CN102416107B (en) | Medicament for treating cerebral vascular disease | |
CN1814250A (en) | Chinese medicine composition for treating liver cirrhosis ascites and use thereof | |
CN101700323B (en) | Pharmaceutical composition for preventing and treating liver cancer | |
CN1316989C (en) | Capsule with dried human placemta and red sage root and its preparing process | |
CN1943677A (en) | A Chinese traditional medicinal composition and its preparation method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050105 Termination date: 20101014 |