CN1768803A - Medicine for treating hypertension and its preparing process - Google Patents
Medicine for treating hypertension and its preparing process Download PDFInfo
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- CN1768803A CN1768803A CNA2004100812180A CN200410081218A CN1768803A CN 1768803 A CN1768803 A CN 1768803A CN A2004100812180 A CNA2004100812180 A CN A2004100812180A CN 200410081218 A CN200410081218 A CN 200410081218A CN 1768803 A CN1768803 A CN 1768803A
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Abstract
The invention relates to a medicament for treating hypertension and its preparing process, wherein the medicament is prepared from astragalus root, eucommia bark, dried rehmannia root, cornus officinalis, kudzu vine root, root bark of tree peony, abalone shell, hooked uncaria, wild chrysanthemum flower, Ligusticum wallichii, achyranthes and cyathula root, poria cocos, poria with hostwood, arborviate seed and red sage root.
Description
Technical field
The present invention relates to the hypertensive medicine of a kind of treatment, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Background technology
Hypertension is the common frdquently encountered disease of serious harm human health.China hypertensive patient is the trend that increases year by year at present, and ill crowd becomes younger day by day.For most hyperpietics,, eat depressor often throughout one's life in case suffer from hypertension.In case after the drug withdrawal, blood pressure often raises again.And take depressor over a long time, and not only bring inconvenience to the patient, also the toxic and side effects that makes the patient brought by medicine inevitably comes to harm patient's physical and mental health.
Summary of the invention
Purpose of the present invention just provides and can treat hypertension effectively, the hyperpietic is used less or a kind of Chinese medicine preparation of inactive depressor.
Another object of the present invention has provided the preparation method of this Chinese medicine preparation.
Medicine of the present invention is made (in kilogram) by the following weight proportion raw material:
The Radix Astragali 50～100, the Cortex Eucommiae 50～150, the Radix Rehmanniae 50～80, Fructus Corni 20～30, Radix Puerariae 10～20, Cortex Moutan 10～20, Concha Haliotidis 20～50, Ramulus Uncariae Cum Uncis 10～30, Flos Chrysanthemi 10～20, Rhizoma Chuanxiong 10～50, Radix Achyranthis Bidentatae 10～60, Poria 10～60, Poria cum Radix Pini 10～60, Semen Platycladi 10～20, Radix Salviae Miltiorrhizae 50～100.
The preferred weight ratio range of preparation medicine of the present invention is (in a kilogram)
The Radix Astragali 60～90, the Cortex Eucommiae 70～120, the Radix Rehmanniae 55～70, Fructus Corni 20～27 Radix Puerariaes 10～18, Cortex Moutan 12～18, Concha Haliotidis 25～45, Ramulus Uncariae Cum Uncis 15～25, Flos Chrysanthemi 10～18, Rhizoma Chuanxiong 15～40, Radix Achyranthis Bidentatae 15～50, Poria 20～50, Poria cum Radix Pini 20～50, Semen Platycladi 10～18, Radix Salviae Miltiorrhizae 55～90.
The optimum weight proportioning of preparation medicine of the present invention is: (in kilogram)
The Radix Astragali 80, the Cortex Eucommiae 100, the Radix Rehmanniae 65, Fructus Corni 25, Radix Puerariae 15, Cortex Moutan 15, Concha Haliotidis 35, Ramulus Uncariae Cum Uncis 20, Flos Chrysanthemi 15, Rhizoma Chuanxiong 30, Radix Achyranthis Bidentatae 35, Poria 35, Poria cum Radix Pini 35, Semen Platycladi 15, Radix Salviae Miltiorrhizae 75.
Above-mentioned each component is made medicine production method of the present invention is:
With each raw material by described weight proportion batching after, pulverize, mix, add an amount of amino acid solution mixing again, pelletize then, drying, tabletting get finished product.
Above-mentioned pulverizing adopts the Baily pulverizing mill to pulverize, and the raw material powder particle size after pulverizing is less than or equal to 300 orders.
The concentration of above-mentioned amino acid solution is 20～25%.
Medicine of the present invention is pressed the theoretical prescription of Chinese medicine and pharmacy, with Ramulus Uncariae Cum Uncis, Flos Chrysanthemi, Concha Haliotidis suppressing the hyperactive liver and subsiding YANG; The Radix Rehmanniae, Cortex Moutan YIN nourishing removing heat from blood; Radix Astragali pathogenic fire purging; The Radix Achyranthis Bidentatae conducting blood to flow downwards; Semen Platycladi, Poria, the Poria cum Radix Pini relieving restlessness of calming the nerves; The Cortex Eucommiae, Fructus Corni invigorating the liver and kidney are to consolidate; Full side has the function of nourishing YIN for suppressing the hyperactive YANG, suppressing the hyperactive liver pathogenic fire purging, liver and kidney tonifying.This side is for the hyperpietic, but treating both the principal and the secondary aspects of a disease at the same time, and anti-apoplexy is in possible trouble.Add Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Puerariae, expelling pathogenic factors from muscles for reducing heat, blood-activating and qi-promoting, reducing swelling and alleviating pain especially are suitable for type of deficiency of YIN leading to hyper activity of YANG hypertension.
The preparation technology of medicine of the present invention brings following beneficial effect also for medicine of the present invention:
1, improved bioavailability of medicament of the present invention.
Owing to adopted cell grade micropowder technology, promptly to pulverize, mix by the Baily pulverizing mill, the Chinese medicine micropowder that obtains can reach 300 mesh sieves (300 mesh sieve internal diameters are 47 microns) all-pass mistake, and is littler 1 times than Chinese crude drug fine powder 200 orders of Chinese Pharmacopoeia regulation in 2000.In crushing process, medical material has been subjected to the effect of intensive forward extrusion power and radial shear power, and cell is extruded, shears, and cell wall is torn, disconnected, and cell is fractured into fragment or is crushed, and various compositions are when pulverizing, by abundant mixing.And after the cell wall breaking, the content in the breaking cellular wall cell is solvent contact directly, and its effective ingredient can all directly enter solvent and be absorbed by the body; And most cells are complete in general pulverized particles and decoction pieces, its particle by several, dozens of in addition more many cells form.The course of dissolution of the effective medicinal ingredient in the cell need pass several even the dozens of cell wall just can enter in the solvent, then be absorbed by the body, and quite a few cell component can not pass cell wall and enter solvent, and this part can only waste.Therefore, the effective ingredient emission of cell ultrafine Chinese herb all can be than the Chinese medicinal powder height that common breaking method obtained with the amount of disengaging human drug absorption's effective ingredient in speed, unit interval, and effective ingredient that it disengages and kind are also complete than common breaking method.Drug effect onset time can significantly shorten, drug effect to the effect of human body more comprehensively, action intensity is bigger.
2, strengthened the medicinal effects of medicine of the present invention.
Among the present invention owing to added the aminoacid organic molecule, easily with the present invention in effective ingredient formation complex or chela and thing, make the effective ingredient lipid barrier by intestinal wall mucomembranous cell film rapidly among the present invention, absorbed by body and utilize, thereby improved medicinal effects of the present invention greatly.After pharmaceutically active ingredient enters human body in the amino-acid complex in addition, at first will be in body the effect of profitable strain, because cell grade ultrafine Chinese herb particle is little, the effect meeting of profitable strain is rapider, stronger, quality and concentration through the product of flora effect can obviously improve, this also is of value to absorption by human body, improves absorption intensity, strengthens medicinal effects of the present invention.
3, reduce cost, improved product quality.
In the medicine of the present invention, along with reducing of Chinese crude drug granularity, dosage significantly descends, and has directly reduced cost.The present invention has saved the starch excipient in the tablet conventional production process in addition, and it is nearly 30% that sheet heavily reduces, and highly polished, the hardness height had both reduced cost, had improved product quality again.
In order to understand the therapeutic effect of medicine of the present invention, 104 routine hyperpietics have been treated with observed drug of the present invention.104 routine patients by doctor trained in Western medicine hypertension staging diagnosis are: II phases 59 example, III phases 45 example; Wherein merge cerebrovascular 40 examples, coronary heart disease 41 examples, uremia's 3 examples.Debate disease by the traditional Chinese medical science: stagnation of phlegm-damp folder congestion type 56 examples, hepatic and renal YIN deficiency congestion type 25 examples of holding concurrently, excessive rising of liver-YANG congestion type 17 types of holding concurrently, both Qi and blood deficiency 6 examples.With Drug therapy 104 routine patients of the present invention, the course of treatment is the shortest 12 days, and is the longest 190 days, average course of treatment 56 days.As a result, remarkable result 70 examples, effective 26 examples, invalid 8 examples, total effective rate 92.3%.Follow up a case by regular visits among this 104 routine patient, inactive other depressor blood pressure stabilization person's 30 examples more than 6 months, person's 8 examples more than 2 years, person's 59 examples more than 3 years, 7 examples are unstable.
The specific embodiment
The invention will be further described below in conjunction with embodiment and table 1:
Table 1
| Material name | Embodiment 1 (weight proportion) | Embodiment 2 (weight proportion) | Embodiment 3 (weight proportion) | Embodiment 4 (weight proportion) | Embodiment 5 (weight proportion) | Embodiment 6 (weight proportion) |
| Radix Astragali bark of eucommia dried rhizome of rehmannia Fructus Corni root of kudzu vine root bark of tree peony Concha Haliotidis hook Teng chrysanthemum Ligusticum wallichii root of bidentate achyranthes Poria cocos fushen seed of Oriental arborvitae red sage root | 50 50 50 20 10 10 20 10 10 10 10 10 10 10 50 | 60 70 55 21 12 12 25 15 12 15 15 20 20 12 55 | 70 90 60 23 14 13 30 16 14 25 26 26 26 14 67 | 80 100 65 25 15 15 35 20 15 30 35 35 35 15 75 | 90 120 70 27 18 18 45 25 18 40 50 50 50 18 90 | 100 150 80 30 20 20 50 30 20 50 60 60 60 20 100 |
Embodiment 1: behind the weight proportion prescription by embodiment 1 in the last table, pulverize, mix by the Baily pulverizing mill, and the raw material powder particle size after pulverizing is less than or equal to 300 orders.Add an amount of amino acid solution mixing again, pelletize then, drying, tabletting get finished product.Wherein the concentration of amino acid solution is 20%.
Embodiment 2: by the weight proportion prescription of embodiment 2 in the last table, method for making is with embodiment 1.Wherein the concentration of amino acid solution is 22%.
Embodiment 3: by the weight proportion prescription of embodiment 3 in the last table, method for making is with embodiment 1.Wherein the concentration of amino acid solution is 22%.
Embodiment 4: by the weight proportion prescription of embodiment 4 in the last table, method for making is with embodiment 1.Wherein the concentration of amino acid solution is 23%.
Embodiment 5: by the weight proportion prescription of embodiment 5 in the last table, method for making is with embodiment 1.Wherein the concentration of amino acid solution is 25%.
Embodiment 6: by the weight proportion prescription of embodiment 6 in the last table, method for making is with embodiment 1.Wherein the concentration of amino acid solution is 25%.
Claims (6)
1, the hypertensive medicine of a kind of treatment, it is characterized in that it is the medicament of being made by the following weight proportion raw material, in kilogram: the Radix Astragali 50～100, the Cortex Eucommiae 50～150, the Radix Rehmanniae 50～80, Fructus Corni 20～30, Radix Puerariae 10～20, Cortex Moutan 10～20, Concha Haliotidis 20～50, Ramulus Uncariae Cum Uncis 10～30, Flos Chrysanthemi 10～20, Rhizoma Chuanxiong 10～50, Radix Achyranthis Bidentatae 10～60, Poria 10～60, Poria cum Radix Pini 10～60, Semen Platycladi 10～20, Radix Salviae Miltiorrhizae 50～100.
2, the hypertensive medicine of treatment according to claim 1, wherein the consumption of each raw material is: the Radix Astragali 60～90, the Cortex Eucommiae 70～120, the Radix Rehmanniae 55～70, Fructus Corni 20～27, Radix Puerariae 10～18, Cortex Moutan 12～18, Concha Haliotidis 25～45, Ramulus Uncariae Cum Uncis 15～25, Flos Chrysanthemi 10～18, Rhizoma Chuanxiong 15～40, Radix Achyranthis Bidentatae 15～50, Poria 20～50, Poria cum Radix Pini 20～50, Semen Platycladi 10～18, Radix Salviae Miltiorrhizae 55～90.
3, the hypertensive medicine of treatment according to claim 1, wherein the consumption of each raw material is: the Radix Astragali 80, the Cortex Eucommiae 100, the Radix Rehmanniae 65, Fructus Corni 25, Radix Puerariae 15, Cortex Moutan 15, Concha Haliotidis 35, Ramulus Uncariae Cum Uncis 20, Flos Chrysanthemi 15, Rhizoma Chuanxiong 30, Radix Achyranthis Bidentatae 35, Poria 35, Poria cum Radix Pini 35, Semen Platycladi 15, Radix Salviae Miltiorrhizae 75.
4, according to the preparation method of claim 1, the hypertensive medicine of 2 or 3 described treatments, it is characterized in that: after described raw material is prepared burden by described weight proportion, pulverize, mix, add an amount of amino acid solution mixing again, pelletize then, drying, tabletting get finished product.
5, the preparation method of the hypertensive medicine of treatment according to claim 4 is characterized in that: described pulverizing adopts the Baily pulverizing mill to pulverize; The concentration of described amino acid solution is 20～25%.
6, the preparation method of the hypertensive medicine of treatment according to claim 5 is characterized in that: the raw material powder particle size after pulverizing by described Baily pulverizing mill is less than or equal to 300 orders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100812180A CN100467037C (en) | 2004-11-05 | 2004-11-05 | Medicine for treating hypertension and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100812180A CN100467037C (en) | 2004-11-05 | 2004-11-05 | Medicine for treating hypertension and its preparing process |
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| Publication Number | Publication Date |
|---|---|
| CN1768803A true CN1768803A (en) | 2006-05-10 |
| CN100467037C CN100467037C (en) | 2009-03-11 |
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| CNB2004100812180A Expired - Fee Related CN100467037C (en) | 2004-11-05 | 2004-11-05 | Medicine for treating hypertension and its preparing process |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965933B (en) * | 2006-11-28 | 2010-06-16 | 钟圣鼎 | Medicated tea for lowering blood pressure and method for preparing same |
| CN101214306B (en) * | 2008-01-08 | 2010-10-06 | 魏小琴 | Chinese herbal medicine for treating high blood pressure |
| CN101301398B (en) * | 2008-04-03 | 2010-12-29 | 乔兴茂 | Chinese medicine for treating hypertension |
| CN101264150B (en) * | 2007-03-13 | 2011-03-16 | 王小良 | Chinese medicinal composition containing radix astragali and preparation thereof |
| CN101214339B (en) * | 2008-01-11 | 2011-09-07 | 邵厚仁 | Hypertension-treating medicine and preparation thereof |
| CN102423421A (en) * | 2011-12-06 | 2012-04-25 | 陈中元 | Medicine for treating hypertension |
-
2004
- 2004-11-05 CN CNB2004100812180A patent/CN100467037C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965933B (en) * | 2006-11-28 | 2010-06-16 | 钟圣鼎 | Medicated tea for lowering blood pressure and method for preparing same |
| CN101264150B (en) * | 2007-03-13 | 2011-03-16 | 王小良 | Chinese medicinal composition containing radix astragali and preparation thereof |
| CN101214306B (en) * | 2008-01-08 | 2010-10-06 | 魏小琴 | Chinese herbal medicine for treating high blood pressure |
| CN101214339B (en) * | 2008-01-11 | 2011-09-07 | 邵厚仁 | Hypertension-treating medicine and preparation thereof |
| CN101301398B (en) * | 2008-04-03 | 2010-12-29 | 乔兴茂 | Chinese medicine for treating hypertension |
| CN102423421A (en) * | 2011-12-06 | 2012-04-25 | 陈中元 | Medicine for treating hypertension |
| CN102423421B (en) * | 2011-12-06 | 2014-06-11 | 陈中元 | Medicine for treating hypertension |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100467037C (en) | 2009-03-11 |
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Effective date of registration: 20170410 Address after: 629300 Suining County, Sichuan City, the British Industrial Development Zone, the focus of the ditch Patentee after: British day Dan Chinese herbal medicine science and Technology Co., Ltd. Address before: 402760 Chongqing City, Bishan city along the North River Road, No. 94, No. 5-2, No. 3 Patentee before: He Quanlin |
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Effective date of registration: 20191107 Address after: 402763 group 12, Laifeng village, Laifeng street, Bishan District, Chongqing Patentee after: Chongqing Maolin Agricultural Biotechnology Co., Ltd Address before: 629300 Industrial Development Zone, Daying County, Sichuan City, Suining Province Patentee before: British day Dan Chinese herbal medicine science and Technology Co., Ltd. |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090311 Termination date: 20191105 |