CN1947786A - Medicine for treating and preventing neurosis and its prepn. method - Google Patents
Medicine for treating and preventing neurosis and its prepn. method Download PDFInfo
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- CN1947786A CN1947786A CNA2005100222027A CN200510022202A CN1947786A CN 1947786 A CN1947786 A CN 1947786A CN A2005100222027 A CNA2005100222027 A CN A2005100222027A CN 200510022202 A CN200510022202 A CN 200510022202A CN 1947786 A CN1947786 A CN 1947786A
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Abstract
An orally taken Chinese medicine for treating the neurosis, such as depression, anxiety, insomnia, neurasthenia, etc, is prepared from flavescent sophora root, grass-leaved sweetflag rhizome, bupleurum root, curcuma root and white peony root. Its preparing process is also disclosed.
Description
Technical field the present invention relates to a kind of medicine and preparation method thereof, relates in particular to a kind of particularly preparation method of capsule of neurosal medicine and preparation thereof for the treatment of and prevent.
The background technology neurosis is a kind of disease of serious harm human health, the understanding that modern medicine is not agreed as yet to this sick pathogeny.Diseases such as the neurasthenia in the neurosis, anxiety neurosis mainly belong to the category of " melancholia " in the Chinese medicine, also sporadically appear among the argumentation of diseases such as " being insomnia ", " Bulbus Lilii syndrome " simultaneously.Clinical dialectically have void that reality is arranged, the many and fire caused by depression of liver-QI of excess syndrome, and stagnation of QI Tianjin is coagulated and is expectorant, and intimately holding expectorant under the arm, to disturb the heart relevant.As a whole, this onset of disease body is real, and pathological changes is based on the stagnation of QI, and the blood stasis of often holding concurrently, fire-transformation, expectorant coagulate etc., how true card.Prolongedly do not heal, then Sthenia is transforming into asthenia.Though Chinese medicine and pharmacy has accumulated rich experience to the treatment of this disease, clinically to sick still incomparable satisfied medicine such as the neurasthenia in the neurosis, anxiety neurosis.Chinese invention patent 200510016580 discloses a kind of prescription for the treatment of depression, neurosis etc., wherein contains 17 flavor Chinese medicines such as Radix Bupleuri, Rhizoma Cyperi, Radix Curcumae, the Radix Aucklandiae.But it does not treat the neurasthenia in the neurosis, the effect of anxiety neurosis, do not clear away heart-fire yet and reduce phlegm, and dispersing the stagnated live-QI to relieve the stagnation of QI, the function of mind tranquilizing and the heart calming, and also used flavour of a drug are more.
Summary of the invention an object of the present invention is to provide diseases such as neurasthenia in a kind of treatment and the prevention neurosis, anxiety neurosis, has to clear away heart-fire and reduce phlegm, dispersing the stagnated live-QI to relieve the stagnation of QI, the medicine of the function of mind tranquilizing and the heart calming.Another object of the present invention provides a kind of method of this pharmaceutical preparation of preparation, particularly prepares the method for its capsule.
This medicine contains the raw material of Chinese medicine of following weight parts ratio: Radix Sophorae Flavescentis 300～500, Rhizoma Acori Graminei 140～240, Radix Bupleuri 140～240, Radix Curcumae 140～240, the Radix Paeoniae Alba 300～500.
This medicine can also contain a kind of raw material of Chinese medicine of following weight parts ratio, or the combination of several raw material of Chinese medicine: Cortex Magnoliae Officinalis 140～240, Fructus Aurantii 200～300, Os Draconis 300～500, Concha Ostreae 300～500, Semen Ziziphi Spinosae 140～240, Fructus Schisandrae Chinensis 140～240.
Preferred weight part ratio of the raw material of Chinese medicine in this medicine is: Radix Sophorae Flavescentis 360～400, Rhizoma Acori Graminei 180～200, Radix Bupleuri 180～200, Radix Curcumae 180～200, the Radix Paeoniae Alba 360～400, Cortex Magnoliae Officinalis 180～200, Fructus Aurantii 240～260, Os Draconis 360～400, Concha Ostreae 360～400, Semen Ziziphi Spinosae 180～200, Fructus Schisandrae Chinensis 180～200.
The optimum weight portion ratio of the raw material of Chinese medicine in this medicine is: Radix Sophorae Flavescentis 380, Rhizoma Acori Graminei 190, Radix Bupleuri 190, Radix Curcumae 190, the Radix Paeoniae Alba 380, Cortex Magnoliae Officinalis 190, Fructus Aurantii 252, Os Draconis 380, Concha Ostreae 380, Semen Ziziphi Spinosae 190, Fructus Schisandrae Chinensis 190.
In order to guarantee the quality of the preparation that this medicine is made, the present invention divides the Rhizoma Acori Graminei in the raw material of Chinese medicine, Radix Bupleuri, Radix Curcumae, Fructus Schisandrae Chinensis, Fructus Aurantii, Cortex Magnoliae Officinalis into one group when the preparation preparation, add water distillation and extraction volatile oil, and medicinal residues filter, filtrate for later use; Remaining Radix Sophorae Flavescentis, the Radix Paeoniae Alba, Os Draconis, Concha Ostreae, Semen Ziziphi Spinosae divide another group into, decoct with water, and decoction liquor filters, filtrate for later use; Medicinal residues behind medicinal residues and the said extracted volatile oil merge, and decoct with water 2～3 times again, and decoction liquor merges, and filter, and filtrate and above-mentioned two filtrates merge, and concentrate; Adopt preparation method conventional on the pharmaceutics, and merge above-mentioned volatile oil, make various oral solid formulations or oral liquids such as tablet, capsule, granule, pill, powder, medicinal tea, mixture, syrup, soft extract, oral suspensions, drop pill.
Through the decocting condition of determining be: add 6～12 times of water gagings, little boiling decocted 0.5～2 hour at every turn.
According to result of study, the formulation method of the medicine of the present invention particularly preferred for preparation method of capsule is:
Get Rhizoma Acori Graminei, Radix Bupleuri, Radix Curcumae, Fructus Schisandrae Chinensis, Fructus Aurantii, Cortex Magnoliae Officinalis and add water distillation and extraction volatile oil, medicinal residues filter, filtrate for later use; Radix Sophorae Flavescentis, the Radix Paeoniae Alba, Os Draconis, Concha Ostreae, Semen Ziziphi Spinosae add 10 times of water gagings and decoct, little boiling 1 hour, and decoction liquor filters, filtrate for later use, the medicinal residues behind medicinal residues and the said extracted volatile oil merge, and decoct with water 2 times again, add 10 times of water gagings at every turn, little boiling 1 hour, decoction liquor merges, filter, filtrate and above-mentioned two filtrates merge, and being evaporated to relative density is the clear paste of 1.12～1.20 (60～80 ℃), adding starch granulates, spray into above-mentioned volatile oil, incapsulate, promptly.
Animal experiment proves that medicine of the present invention can obviously reduce the activity of mice, shortens the time for falling asleep of mice and prolongs the length of one's sleep (being P＜0.05) of mice, reduces the convulsions reaction of mice.Acute and long term toxicity test is not seen obvious toxic-side effects and other untoward reaction.Clinical research proves, 2～3 of the capsules of each oral medicine of the present invention, every day 3 times, the January course of treatment, to the effective percentage in the pathogenic fire derived from stagnation of liver-QI card total effects is 95.04%, traditional Chinese medical science body and mental symptom that multiple pathogenic fire derived from stagnation of liver-QI such as headache, dizzy, flushing conjunctival congestion, xerostomia pharynx hardship, sternal rib pain, insomnia and dreamful sleep are demonstrate,proved are clearly better, and are 96.72% to the effective percentage of anxiety neurosis, are 93.33% to neurasthenic effective percentage.So medicine of the present invention has to clear away heart-fire and reduces phlegm, dispersing the stagnated live-QI to relieve the stagnation of QI, the function of mind tranquilizing and the heart calming is used for the disease such as depressed, anxious, insomnia and dreamful sleep due to the pathogenic fire derived from stagnation of liver-QI, and anxiety neurosis, neurasthenia belong to pathogenic fire derived from stagnation of liver-QI card person.
The specific embodiment comes further to set forth medicine of the present invention and formulation preparation method thereof by the following examples.
Embodiment 1: the preparation of medicinal tablet of the present invention
Get Radix Sophorae Flavescentis 340g, Rhizoma Acori Graminei 160g, Radix Bupleuri 220g, Radix Curcumae 170g, Radix Paeoniae Alba 420g, wherein Rhizoma Acori Graminei, Radix Bupleuri, Radix Curcumae add water distillation and extraction volatile oil, and medicinal residues filter, filtrate for later use; Radix Sophorae Flavescentis, the Radix Paeoniae Alba add 10 times of water gagings and decocted 2 hours, and decoction liquor filters, filtrate for later use; Medicinal residues behind medicinal residues and the said extracted volatile oil merge, and decoct with water 3 times again, add 8 times of water gagings at every turn, decocted 1 hour, decoction liquor merges, and filters, filtrate and above-mentioned two filtrates merge, concentrate, spray drying is pulverized the back and is added the starch granulation, spray into above-mentioned volatile oil, be pressed into 1000, every 0.5g, promptly.
Oral, 1-5 sheet at every turn, every day 1-5 time; With each 2-3 sheet, be that be best dosage regimen a course of treatment with 8 days every day 3 times.
Embodiment 2: the preparation of medicine capsule of the present invention
Get Radix Sophorae Flavescentis 380g, Rhizoma Acori Graminei 190g, Radix Bupleuri 190g, Radix Curcumae 190g, Radix Paeoniae Alba 380g, Cortex Magnoliae Officinalis 190g, Fructus Aurantii 252g, Os Draconis 380g, Concha Ostreae 380g, Semen Ziziphi Spinosae 190g, Fructus Schisandrae Chinensis 190g, wherein Rhizoma Acori Graminei, Radix Bupleuri, Radix Curcumae, Fructus Schisandrae Chinensis, Fructus Aurantii, Cortex Magnoliae Officinalis add water distillation and extraction volatile oil, and medicinal residues filter, filtrate for later use; Radix Sophorae Flavescentis, the Radix Paeoniae Alba, Os Draconis, Concha Ostreae, Semen Ziziphi Spinosae add 10 times of water gagings and decoct, little boiling 1 hour, decoction liquor filters, filtrate for later use, and the medicinal residues behind medicinal residues and the said extracted volatile oil merge, decoct with water again 2 times, add 10 times of water gagings at every turn, little boiling 1 hour, decoction liquor merges, filter, filtrate and above-mentioned two filtrates merge, and being evaporated to relative density is the clear paste of 1.12～1.20 (60～80 ℃), is bed material with starch, spray into clear paste and carry out one-step palletizing, spray into above-mentioned volatile oil, mixing is made 1000 of capsules, every 0.5g, promptly.
Oral, 1-5 grain at every turn, every day 1-5 time; With each 2-3 grain, be that be best dosage regimen a course of treatment with 8 days every day 3 times.
Embodiment 3: the preparation of medicinal tablet of the present invention
Get Radix Sophorae Flavescentis 390g, Rhizoma Acori Graminei 195g, Radix Bupleuri 185g, Radix Curcumae 195g, Radix Paeoniae Alba 370g, Cortex Magnoliae Officinalis 185g, Fructus Aurantii 245g, Os Draconis 390g, wherein Rhizoma Acori Graminei, Radix Bupleuri, Radix Curcumae, Fructus Aurantii, Cortex Magnoliae Officinalis add water distillation and extraction volatile oil, and medicinal residues filter, filtrate for later use; Radix Sophorae Flavescentis, the Radix Paeoniae Alba, Os Draconis add 8 times of water gagings and decoct, little boiling 1 hour, and decoction liquor filters, filtrate for later use, medicinal residues behind medicinal residues and the said extracted volatile oil merge, and decoct with water 2 times again, add 6 times of water gagings at every turn, little boiling 1 hour, decoction liquor merges, and filters, and filtrate and above-mentioned two filtrates merge, being evaporated to relative density is the clear paste of 1.13～1.15 (60～80 ℃), add 2 times of amount ethanol, fully stir and left standstill the leaching supernatant 24 hours, reclaim ethanol, at 70～80 ℃, being evaporated to relative density under the-0.1MPa condition is the clear paste of 1.12～1.20 (60～80 ℃), is bed material with starch, sprays into clear paste and carries out one-step palletizing, spray into above-mentioned volatile oil, mixing is pressed into 1000, every 0.4g, the bag film-coat, promptly.
Oral, 1-5 sheet at every turn, every day 1-5 time; With each 2-3 sheet, be that be best dosage regimen a course of treatment with 8 days every day 3 times.
Embodiment 4: the preparation of drug mixture of the present invention
Get Radix Sophorae Flavescentis 370g, Rhizoma Acori Graminei 175g, Radix Bupleuri 185g, Radix Curcumae 176g, Radix Paeoniae Alba 375g, Cortex Magnoliae Officinalis 196g, Fructus Aurantii 255g, Os Draconis 375g, Concha Ostreae 380g, Semen Ziziphi Spinosae 195g, Fructus Schisandrae Chinensis 185g, wherein Rhizoma Acori Graminei, Radix Bupleuri, Radix Curcumae, Fructus Schisandrae Chinensis, Fructus Aurantii, Cortex Magnoliae Officinalis add water distillation and extraction volatile oil, and medicinal residues filter, filtrate for later use; Radix Sophorae Flavescentis, the Radix Paeoniae Alba, Os Draconis, Concha Ostreae, Semen Ziziphi Spinosae adds 10 times of water gagings and decocted 1 hour, and decoction liquor filters, filtrate for later use, medicinal residues behind medicinal residues and the said extracted volatile oil merge, and decoct with water 2 times again, add 8 times of water gagings at every turn, decocted 1 hour, decoction liquor merges, and filters, filtrate and above-mentioned two filtrates merge, and being evaporated to relative density is the clear paste of 1.12～1.15 (60～80 ℃), add 3 times of amount ethanol, fully stir and leave standstill, the leaching supernatant reclaims ethanol, be concentrated into about 4000ml, centrifugal, get supernatant, add cyclamate 2.0g, sorbic acid 10g, polyoxyethylene sorbitan monoleate 45g, mixing, add water to 5000ml, filter fill, sterilization, promptly.
Oral, 10-30ml at every turn, every day 1-5 time; With each 10-15ml, be that be best dosage regimen a course of treatment with 8 days every day 3 times.
Set forth below good effect of the present invention:
The present invention has to clear away heart-fire reduces phlegm, soothing liver-qi stagnation, the function of antitoxic heart-soothing and sedative, be used for due to the liver depression forming fire depressed, anxiety not Diseases such as peace, insomnia and dreamful sleep, and the anxiety disorder in the neurosis, neurasthenia belong to liver depression forming fire card person, and have no that poison is secondary to be done With reaching other bad reaction.
Claims (10)
1. one kind is used for the treatment of and prevents neurosal medicine, it is characterized in that it contains the raw material of Chinese medicine of following weight parts ratio:
Radix Sophorae Flavescentis 300～500, Rhizoma Acori Graminei 140～240, Radix Bupleuri 140～240, Radix Curcumae 140～240, the Radix Paeoniae Alba 300～500.
2. medicine according to claim 1 is characterized in that it also contains a kind of raw material of Chinese medicine of following weight parts ratio, or the combination of several raw material of Chinese medicine:
Cortex Magnoliae Officinalis 140～240, Fructus Aurantii 200～300, Os Draconis 300～500, Concha Ostreae 300～500, Semen Ziziphi Spinosae 140～240, Fructus Schisandrae Chinensis 140～240.
3. medicine according to claim 1 is characterized in that its weight portion ratio is:
Radix Sophorae Flavescentis 360～400, Rhizoma Acori Graminei 180～200, Radix Bupleuri 180～200, Radix Curcumae 180～200, the Radix Paeoniae Alba 360～400.
4. medicine according to claim 2 is characterized in that its weight portion ratio is:
Cortex Magnoliae Officinalis 180～200, Fructus Aurantii 240～260, Os Draconis 360～400, Concha Ostreae 360～400, Semen Ziziphi Spinosae 180～200, Fructus Schisandrae Chinensis 180～200.
5. according to claim 1 or 3 described medicines, it is characterized in that its weight portion ratio is:
Radix Sophorae Flavescentis 380, Rhizoma Acori Graminei 190, Radix Bupleuri 190, Radix Curcumae 190, the Radix Paeoniae Alba 380.
6. according to claim 2 or 4 described medicines, it is characterized in that its weight portion ratio is:
Cortex Magnoliae Officinalis 190, Fructus Aurantii 252, Os Draconis 380, Concha Ostreae 380, Semen Ziziphi Spinosae 190, Fructus Schisandrae Chinensis 190.
7. preparation is characterized in that as the formulation method of medicine as described in the claim 1～6:
Divide the Rhizoma Acori Graminei in the raw material of Chinese medicine, Radix Bupleuri, Radix Curcumae, Fructus Schisandrae Chinensis, Fructus Aurantii, Cortex Magnoliae Officinalis into one group, add water distillation and extraction volatile oil, medicinal residues filter, filtrate for later use; Remaining Radix Sophorae Flavescentis, the Radix Paeoniae Alba, Os Draconis, Concha Ostreae, Semen Ziziphi Spinosae divide another group into, decoct with water, and decoction liquor filters, filtrate for later use; Medicinal residues behind medicinal residues and the said extracted volatile oil merge, and decoct with water 2～3 times again, and decoction liquor merges, and filter, and filtrate and above-mentioned two filtrates merge, and concentrate; Adopt preparation method conventional on the pharmaceutics, and merge above-mentioned volatile oil, make tablet, capsule, granule, pill, powder, medicinal tea, mixture, syrup, soft extract, oral suspensions, these oral solid formulations of drop pill or oral liquid.
8. formulation method according to claim 7 is characterized in that:
Add 6～12 times of water gagings when decocting with water, little boiling decocted 0.5～2 hour at every turn.
9. according to claim 7 or 8 described formulation methods, it is characterized in that the preparation method of described capsule is:
Get Rhizoma Acori Graminei, Radix Bupleuri, Radix Curcumae, Fructus Schisandrae Chinensis, Fructus Aurantii, Cortex Magnoliae Officinalis and add water distillation and extraction volatile oil, medicinal residues filter, filtrate for later use; Radix Sophorae Flavescentis, the Radix Paeoniae Alba, Os Draconis, Concha Ostreae, Semen Ziziphi Spinosae add 10 times of water gagings and decoct, little boiling 1 hour, and decoction liquor filters, filtrate for later use, the medicinal residues behind medicinal residues and the said extracted volatile oil merge, and decoct with water 2 times again, add 10 times of water gagings at every turn, little boiling 1 hour, decoction liquor merges, filter, filtrate and above-mentioned two filtrates merge, and being evaporated to relative density is the clear paste of 1.12～1.20 (60～80 ℃), adding starch granulates, spray into above-mentioned volatile oil, incapsulate, promptly.
10. as claim 1 and 5 and 7 described treatments with prevent neurosal medicine, it is characterized in that having clearing away heart-fire and reduce phlegm, dispersing the stagnated live-QI to relieve the stagnation of QI, the function of mind tranquilizing and the heart calming, be used for the disease such as depressed, anxious, insomnia and dreamful sleep due to the pathogenic fire derived from stagnation of liver-QI, and the anxiety neurosis in the neurosis, neurasthenia belong to pathogenic fire derived from stagnation of liver-QI card person, and do not see toxic and side effects and other untoward reaction.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244244B (en) * | 2008-03-05 | 2010-07-14 | 四川省中医药科学院 | Depression treating medicine composition and preparation method thereof |
| CN102461892A (en) * | 2010-11-11 | 2012-05-23 | 卢卫红 | Formula and preparation method of portable functional food for stress after disaster |
| CN103041027A (en) * | 2013-01-25 | 2013-04-17 | 孙丽 | Traditional Chinese medicine for treating liver depression forming fire syndrome type insomnia |
| CN103463214A (en) * | 2013-08-14 | 2013-12-25 | 西北大学 | Anti-anxiety medicament and preparation method thereof |
| CN104117014A (en) * | 2014-07-09 | 2014-10-29 | 济南伟传信息技术有限公司 | Traditional Chinese medicine for treating depression |
| CN105213990A (en) * | 2015-10-29 | 2016-01-06 | 曹桂苟 | A kind of Chinese medicine composition for the treatment of heart neurosis |
| CN105688031A (en) * | 2015-12-04 | 2016-06-22 | 辽宁富东制药有限公司 | Application of compound traditional Chinese medicine preparation in treatment of Alzheimer's disease |
| CN105853944A (en) * | 2016-06-22 | 2016-08-17 | 吴淑芬 | Traditional Chinese medicine for treating liver-depression-transforming-into-fire type insomnia |
-
2005
- 2005-12-02 CN CNB2005100222027A patent/CN100496589C/en active Active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244244B (en) * | 2008-03-05 | 2010-07-14 | 四川省中医药科学院 | Depression treating medicine composition and preparation method thereof |
| CN102461892A (en) * | 2010-11-11 | 2012-05-23 | 卢卫红 | Formula and preparation method of portable functional food for stress after disaster |
| CN103041027A (en) * | 2013-01-25 | 2013-04-17 | 孙丽 | Traditional Chinese medicine for treating liver depression forming fire syndrome type insomnia |
| CN103463214A (en) * | 2013-08-14 | 2013-12-25 | 西北大学 | Anti-anxiety medicament and preparation method thereof |
| CN104117014A (en) * | 2014-07-09 | 2014-10-29 | 济南伟传信息技术有限公司 | Traditional Chinese medicine for treating depression |
| CN105213990A (en) * | 2015-10-29 | 2016-01-06 | 曹桂苟 | A kind of Chinese medicine composition for the treatment of heart neurosis |
| CN105688031A (en) * | 2015-12-04 | 2016-06-22 | 辽宁富东制药有限公司 | Application of compound traditional Chinese medicine preparation in treatment of Alzheimer's disease |
| CN105853944A (en) * | 2016-06-22 | 2016-08-17 | 吴淑芬 | Traditional Chinese medicine for treating liver-depression-transforming-into-fire type insomnia |
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| CN100496589C (en) | 2009-06-10 |
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