CN1440804A - Antilipemic Chinese medicine - Google Patents
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Abstract
The present invention relates to antilipemic Chinese medicine which prepared with bombyx batryticatus, turmeric, cicada slough, kudzu vine root, oriental water plantain and other chinese medicinal materials.
Description
Technical field
The present invention relates to a kind of blood fat reducing Chinese medicine, the particularly Chinese medicine of making by medical materials such as Bombyx Batryticatus, Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, Periostracum Cicadae, Radix Puerariae, Rhizoma Alismatis, Herba Artemisiae Scopariae, Hirudo, Fructus Crataegi, Semen Cassiae, Radix Polygoni Multiflori, Fructus Hordei Germinatus.
Background technology
Hyperlipemia belongs to commonly encountered diseases in clinical, with advancing age, its sickness rate also obviously increases.Hyperlipemia plays an important role in the pathogenesis of arteriosclerosis, coronary heart disease, obesity, causes people's common concern, the control of cardiovascular and cerebrovascular disease is included in public health service in China, puts on an equal footing with the infectious disease control.
Recent two decades comes, and in use medicine is prevented and treated the hyperlipemia aspect and done number of research projects, for new prospect has been opened up in the research of hyperlipemia.In conjunction with modern means of science and technology such as doctors trained in Western medicine, aspect the Chinese medical discrimination basic research, theory of Chinese medical science has had new understanding to hyperlipemia, use the report of Chinese medicine prevention hyperlipemia at present, many-sides such as single medicinal material, compound recipe, acupuncture, the qigong have been related to, find that existing more than 60 kind of Chinese herbal medicine has therapeutical effect to hyperlipemia, with the basis of Chinese medicine and western medicine curative effect comparative study on filter out a collection of Cheng Fangyu folk prescription that the symptom of a trend is arranged.
Yet, even so, still can not satisfy the demand of medical market.According to investigations, at present, existing 80,000,000 people of China suffer from cardiovascular and cerebrovascular disease, and every day is with 10,000 patients' speed increase.Cardiovascular and cerebrovascular disease becomes the leading killer of health risk in China worthy of the namely, and hyperlipemia is the major incentive of cardiovascular and cerebrovascular disease.Thereby, the needing that (accent) fat medicine has become the control cardiovascular and cerebrovascular disease of falling of developing determined curative effect when affair.
At present, the Chinese patent medicine of treatment hyperlipemia is more, mainly contains following several:
1. Yunnan pollen tianqi oral liquid: form by pollen of Semen Fagopyri Esculenti, Typhonium flagelliforme (Lodd.) Blume, Mel.The syndrome of static blood blocking collaterals that is used for hyperlipemia.
2. xinqingning tablet: form by Radix Et Rhizoma Rhei.The pyretic toxicity inner product card that is used for hyperlipemia.
3. fat can be clear: be made up of Semen Lepidii, Radix Scutellariae, Fructus Crataegi, Rhizoma Alismatis, Radix Et Rhizoma Rhei, the Radix Aucklandiae.Be used for accumulateing card in the phlegm-damp of hyperlipemia.
4. Radix Polygoni Multiflori tablet: form by the Radix Polygoni Multiflori.The syndrome of yin deficiency of liver and kidney that is used for hyperlipemia.
5. SHANZHAJING JIANGZHI PIAN: form by Fructus Crataegi.The interior card that stagnates of the food stasis of blood that is used for hyperlipemia.
6. fat-reducing health sheet: form by Rhizoma Alismatis.The insufficiency of the spleen leading to overabundance of dampness card that is used for hyperlipemia.
7. xinmaitong tablet: form by Radix Angelicae Sinensis, Semen Cassiae, Ramulus Uncariae Cum Uncis, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Radix Puerariae, Flos Sophorae, Mao Keqing, Xia Jucao, Radix Notoginseng.The syndrome of static blood blocking collaterals that is used for hyperlipemia.
8. JIANGZHILINGPIAN: form by Radix Polygoni Multiflori Preparata, Semen Cassiae, Rhizoma Polygonati, the Radix Aucklandiae, Fructus Crataegi, Fructus Rosae Laevigatae, Herba Taxilli, Rhizoma Alismatis.The syndrome of yin deficiency of liver and kidney that is used for hyperlipemia.
9. hypogastric lipid-lowering pill: form by Radix Salviae Miltiorrhizae, the Radix Polygoni Multiflori, Radix Ginseng, Rhizoma Polygonati, Radix Notoginseng, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Alismatis, Herba Epimedii, Cortex Acanthopancis, Cortex Cinnamomi.The deficiency of YIN stasis of blood resistance card that is used for hyperlipemia.
Above medicine belongs to a bit cures the symptoms, not the disease, and some uses expensive composition, and some is cut and interrupt using owing to uncertain therapeutic efficacy in application process.
Hyperlipemia, have argumentation in a lot of ancient recordss ancient times, illustrates that ancients have suitable understanding to this disease.As " element ask logical comment deficiency and excess opinion " day " all diseases due to endogenous heat of ZANG FU organs of controlling hit servant, hemiplegia flaccidity with cold limbs, fullness caused by stagnant QI and send out contrary, sweet fertile high official, then the disease of Sorghum vulgare Pers. is also." diseases due to endogenous heat of ZANG FU organs, hit cards such as servant, hemiplegia, fullness caused by stagnant QI, conform to diabetes, cardiovascular and cerebrovascular disease in the modern medicine, these diseases are all closely related with hyperlipemia." disease of sweet fertile high official, Sorghum vulgare Pers. " is meant the people who throws off restraint sweet greasy, the obesity of food, loving ease and hating work.Delicious food reduces phlegm, and fertile people's excessive phlegm is given birth to heat, given birth to wind by expectorant.Modern medicine confirms that the dietary structure and the obesity of hyperlipemia and high fat have direct relation, is the key factor that causes diabetes, cardiovascular and cerebrovascular disease.The mechanism that this and motherland's medical science are set forth: " the living expectorant of diet savoury-accumulate is turbid-and resistance hesitant pulse road-diseases due to endogenous heat of ZANG FU organs hits the servant, hemiplegia flaccidity with cold limbs is " very identical.What illustrate this mechanism the earliest is apart from modern about 3,000 years " interior warp ".
Hyperlipemia is from the elaboration and the clinical syndrome differentiation analysis of ancient books and records, though clinical manifestation is different, and the pattern of syndrome difference, expectorant is turbid to be principal element.The reason of the turbid generation of expectorant has two: one, addiction to greasy and sweet foods, and obesity, good ease is few moving; The 2nd, come to one's autumn, Liver and kidney declines, and the body fluid metabolism is not normal.
Addiction to greasy and sweet foods, the form obesity; Delicious food is given birth to expectorant, and fertile people's excessive phlegm to this, is existing clearly argumentation in doctor's nationality, also is the common recognition of medical circles.The spleen being the source of producing phlegm, dysfunction of the spleen in transportation, then can not to change spermatogenesis little for diet, anti-poly-and give birth to wet, give birth to expectorant.The spleen is in charge of sending up essential substances, and The spleen has the function to transport and transform nutrients, the mediate mechanism of qi of the whole body of spleen master, the spleen being in charge of dampness.These functions of spleen all rely the liter of the clear sun of spleen to send out.The spleen must keep its ascending function has only the clear sun liter of spleen to send out spleen ability fortuneization, ability removing dampness, the mechanism of qi of the whole body of could mediating.Dong Yuan sets forth one's views with the lucid yang sending up spleen invigorating, and is the school of invigorating the spleen founder, and visible clear sun rises the significance of sending out.Clear sun rises then, and turbid yin falls: conversely, turbid YIN failing to descend also checks clearly sun and must not rise and send out the mutual hinder of ascending the clear and descending the turbid.All YANG-meridians meeting into the head, peace and quiet mansion; Breast is occupied peaceful and spacious ascending the clear and descending the turbid, the kidney tonifying of invigorating blood circulation by clear sun.
According to above-mentioned analysis, the invention provides a kind of determined curative effect, safe ready, little, the cheap pure traditional Chinese compound medicine of side effect.
Summary of the invention the invention provides a kind of blood fat reducing Chinese medicine preparation, and this medicine is by monarch drug: Bombyx Batryticatus, Radix Et Rhizoma Rhei ministerial drug: Rhizoma Curcumae Longae, Periostracum Cicadae, Radix Puerariae, Rhizoma Alismatis adjuvant drug: Herba Artemisiae Scopariae, Hirudo, Fructus Crataegi, Semen Cassiae, Radix Polygoni Multiflori messenger drug: Fructus Hordei Germinatus is made.
According to theory of Chinese medical science, the main pathogenesis of assertive evidence is a lifting mistake department.Clear YANG failing to ascend is turbid YIN failing to descend then; Turbid YIN failing to descend, then clear sun also must not rise to be sent out, and the biphase hinder of ascending the clear and descending the turbid is so be the main rule of treatment with ascending the clear and descending the turbid.We's ascending the clear and descending the turbid is laid equal stress on, and is a compound recipe, makes one to form by monarch's two ministers four assistants 5.
Bombyx Batryticatus: salty in the mouth, suffering, property is flat, returns lung, Liver Channel.The function expelling wind to relieve convulsion, dissipating phlegm and resolving masses." detailed outline " " wind-phlegm that looses "." Bencao Tujing " Zhang Yuansu of " controlling apoplexy " " abnormal smells from the patient is all thin, and is frivolous and rise, and the yang aspect of yang rises the gas of its clear sun, and the gas of turbid yin oneself fall also." Zhu Danxi " get the gas of its clear liter, the expectorant that the turbid contrary knot that looses stagnates also ".Shi Zhenri " yang invigorating looses fiery, expelling wind and dampness, heat-clearing and toxic substances removing "." the epidemic febrile disease bar is debated " " human body does not have dead and the person of being stale-proof generally, and silkworm is then stiff and be stale-proof, clearing heat in QI system pure person also.Abnormal smells from the patient is all thin, rises also, and the yang aspect of yang also can be changed turbid wetting and makes it to return clearly ".Because of the turbid event of its lucid yang sending upization is monarch.
Radix Et Rhizoma Rhei: the nature and flavor bitter cold, return spleen, stomach, large intestine, liver, pericardium channel.Be good at cleansing the gastrointestinal excess-heat, it is stagnant to remove dryness accumulated in the stomach and intestine, for bitter cold is captured key medicine." herbal classic " " following blood stasis, blood closes cold and heat, broken levy abdominal mass and gathers, the prolonged fluid-retention dyspepsia is cleansed gastrointestinal, pushes away Chen Zhixin, tonneau water paddy, relieving dyspepsia in the accent, peace and the five internal organs "." detailed outline " " dysentery is red white, pain in the abdomen stomachache, dribbling urination, excess-heat dryness accumulated in the stomach and intestine, hectic fever delirium, all burn of jaundice ".
" abnormal smells from the patient is all thick, and the yin aspect of yin pushes away Chen Zhixin, walks and does not keep " cold warm bar distinguish ".Steeping in wine is current up and down, and clear internal organs accumulation of heat is led native strongly fragrant heap soil or fertilizer over and around the roots and stagnated, and by hard addiction, the clearing away phlegm food is led blood stasis ".Turbid yin falls because of clear sun rises then, and turbid yin falls and could rise the ascending the clear and descending the turbid reciprocal causation by clear sun.So Bombyx Batryticatus the lucid yang sending up and Radix Et Rhizoma Rhei are let out the turbid monarch drug that is altogether, with the duty of multiple lifting.
Rhizoma Curcumae Longae: arduous temperature, return liver, spleen channel." be equipped with and want " " it is swollen to remove emaciation due to emotional upset for the gas in the treating blood disorders, therapeutic method to keep the adverse QI flowing downwards removing blood stasis, and power is strong in Radix Curcumae "." cold warm bar is distinguished " " fall the turbid yin in the moon ... the eliminating evil evil of cutting down, circulation of qi promoting is loose strongly fragrant.The therapeutic method to keep the adverse QI flowing downwards is the most prompt, and removing blood stasis is upright logical.Because of falling, it lets out turbid yin, the eliminating evil evil of cutting down, and promoting flow of QI and blood makes inside and outside logical closing and helps letting out of Radix Et Rhizoma Rhei turbid, and the expectorant stagnation resolvation is loose, and thinks minister.
Periostracum Cicadae: sweet-salty, cold in nature, return lung, Liver Channel.Wind-dispelling heat-dissipating, rash is antipruritic, expelling wind to relieve convulsion, removing nebula to improve visual acuity." detailed outline " " control phlegm-accumulating vertigo, the skin pruritus due to wind pathogen, varioliform exanthema is had an itch, tetanus and furuncle toxic swelling skin ulcer "." cold warm bar is distinguished " " get building residual air instituteization, rise also, the yang aspect of yang also.Dispel and see and win wetly, wash heat and detoxify ".Win wetly with its lucid yang sending up, the lucid yang sending upization of auxilliary Bombyx Batryticatus is turbid and be minister.
Radix Puerariae: sweet hot cool, return the taste warp.Relieving muscles diaphoresis, invigorating YANG QI to promote eruption, analgesic promoting the production of body fluid." herbal classic " " main quenching one's thirst, high fever of the body, vomiting, all numbness plays cloudy gas, separates all poison "." pearl sac " " yang invigorating promotes the production of body fluid "." detailed outline " " stagnated fire of loosing "." medication on the analogy of natural things " " its gas is frivolous, inspire gastric qi up ".With its frivolous yang invigorating, inspire gastric qi up, the lucid yang sending up of auxilliary Bombyx Batryticatus also is a minister.
Rhizoma Alismatis: sweet light cold, return kidney, urinary bladder channel, promoting diuresis to eliminate damp pathogen, expel the heat-evil." herbal classic " " water disappears "." not Lu " " book on Chinese herbal medicine is looked for the truth " " dehumidifying of merit patent water " of " cutting off the water " by the bladder three warmers.The turbid descending that can assist Radix Et Rhizoma Rhei because of its eliminating dampness by diuresis is a minister.
Herba Artemisiae Scopariae: hardship is slightly cold, and returns spleen, stomach, liver, gallbladder meridian.Heat clearing away, dampness removing, jaundice eliminating." herbal classic " " the raw pathogenic heat gas of main air, accumulation of heat jaundice "." not Lu " " the whole body jaundice, urine minor benefit "." the western record of ginseng in the inner feelings " " grasping the initial gas of few sun, is can loose with cold, and the heat of kind liver heat removing gallbladder is held concurrently and managed the strongly fragrant of liver and gall ".Because of it grasps the gas of few sun, rise and send out Shu Yu, dampness removing heat clearing away again, ascending the clear and descending the turbid, merit is held concurrently all over the body, so be assistant
Hirudo: Xin Xianping returns Liver Channel, removing blood stasis." herbal classic " " control stagnant blood, blood stasis, the moon closes, and removing blood stasis gathers .... dredging water passages ".Because of lifting mistake department, give birth in expectorant is turbid, check mechanism of qi, the not handsome blood of gas, the blood clots absorbing stagnates, and causes the expectorant stasis of blood and fights and become trouble.In the ascending the clear and descending the turbid, must be aided with the product of blood circulation promoting and blood stasis dispelling.So Hirudo is an adjuvant drug.
Semen Cassiae: salty flat being slightly cold.Return liver, large intestine channel.Clearing away heat to improve acuity of vision, relieving constipation." herbal classic " " main optic atrohic blindness, order are excessive, swelling ophthalmalgia, lacrimation "." property of medicine opinion " " remove liver man heat "." book on Chinese herbal medicine is looked for the truth " " remove interior heat radiation ".The expectorant stasis of blood is strongly fragrant for a long time, heat being transformed from excessive YANG then, the assistant Semen Cassiae be slightly cold light clear it, be adjuvant drug.
Fructus Crataegi: acid is sweet, tepor.Return spleen, stomach, Liver Channel.Promoting digestion and invigorating the stomach, blood circulation promoting and blood stasis dispelling." detailed outline " " be good for the stomach, the row stagnation of QI, the meat that disappears is long-pending, levies abdominal mass, phlegm retention, the feeling of fullness acid regurgitation, the blood pain with distension that stagnates ".Be good for the stomach and be assistant with its promoting blood circulation to remove stagnancy.
Radix Polygoni Multiflori: sweet, bitter, puckery, tepor.Return liver, the heart, kidney channel.Invigorating the liver and kidney, benefiting essence-blood, relieving constipation." detailed outline " " the liver benefiting that nourishes blood, controlling nocturnal emission with astringent drugs kidney tonifying are tonic medicine ".Hyperlipemia is mainly in middle-aged and elderly people, comes to one's autumn, and kidney qi declines, thinks assistant so be aided with invigorating the liver and kidney, the benefiting essence-blood of the Radix Polygoni Multiflori.
Fructus Hordei Germinatus: sweet flat, return the taste warp." not Lu " " help digestion and in "." ginseng west record in declining ": " though be the medicine of taste, and real kind soothing liver-QI gas.. the property together with its long hair, reach than bar in spring-QI, so soothing liver-QI quite imitate also ".Because of it goes into taste, and tool rises and to send out soothing the liver thin, draws all medicines and reaches taste, and so the merit of the ascending the clear and descending the turbid of building together is for making.
Chinese medicine preparation of the present invention has ascending the clear and descending the turbid, and the kidney tonifying effect of invigorating blood circulation cures mainly lifting mistake department, the hyperlipemia of phlegm and blood stasis.Suffer from symptom and be: obesity, head is heavy dizzy, the vexed or double twinge of breast gastral cavity painful abdominal mass, shortness of breath and palpitation, indigestion and loss of appetite mouthful are sticking, soreness of waist and knee has vomiting and nausea.Tongue is dark or ecchymosis, petechia are arranged, greasy and yellow fur, the patient of stringy and rolling pulse or number.
Its prescription of Chinese medicine preparation of the present invention consists of: Bombyx Batryticatus 50-200 part Radix Et Rhizoma Rhei 25-100 part Rhizoma Curcumae Longae 35-140 part Periostracum Cicadae 20-80 part Radix Puerariae 75-300 part Rhizoma Alismatis 50-200 part Herba Artemisiae Scopariae 75-300 part Hirudo 35-140 part Fructus Crataegi 60-240 part Semen Cassiae 50-200 part Radix Polygoni Multiflori 50-200 part Fructus Hordei Germinatus 15-60 part
Preferably: Bombyx Batryticatus 75-133 part Radix Et Rhizoma Rhei 37-66 part Rhizoma Curcumae Longae 52-93 part Periostracum Cicadae 30-53 part Radix Puerariae 112-200 part Rhizoma Alismatis 75-133 part Herba Artemisiae Scopariae 112-200 part Hirudo 52-93 part Fructus Crataegi 90-160 part Semen Cassiae 75-133 part Radix Polygoni Multiflori 75-133 part Fructus Hordei Germinatus 22-40 part
Be more preferably: 30 parts in 100 parts of Fructus Hordei Germinatus of 150 portions of Rhizoma Alismatis of 40 parts of Radix Puerariaes of 70 portions of Periostracum Cicadaes of 50 portions of Rhizoma Curcumae Longaes of 100 parts of Radix Et Rhizoma Rhei of Bombyx Batryticatus, 100 parts of Radix Polygoni Multiflori of 120 parts of Semen Cassiaes of 70 portions of Fructus Crataegis of the 150 portions of Hirudos in 100 portions of Herba Artemisiae Scopariaes chamber
In more than forming, weight is calculated with crude drug, if be unit with the gram, this composition can be made into 1000 doses of pharmaceutical preparatioies, the final drug preparation that described 1000 doses of fingers are made, as make 1000 of capsule preparations, 1000 in tablet, 1000 bags of granules, oral liquid 1000 ampoules etc. also can be made big packing as granule, as the 100-500 bag, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, as if being unit with the gram, can be made into the preparation of 50-1000 taking dose, as tablet, make 1000, each taking dose can be the 1-20 sheet, can take 50-1000 time altogether.As granule, make 125 bags, take the 1-2 bag at every turn, can take 62.5-125 time altogether.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be a unit with milli part also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, and for especial patient, the proportioning of can corresponding adjustment forming increases or reduce being no more than 100%.
Single medicinal material, especially ministerial drug and adjuvant drug in more than forming also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc., preferably granule.
Preparation of the present invention is determined usage and dosage according to patient's situation in use, but obeys every day three times, each 1-20 agent, as: 1-20 bag or grain or sheet.
Chinese medicine preparation of the present invention prepares by the following method.
1. by the accurate weighing Bombyx Batryticatus of prescription, cold drying is pulverized, and crosses 100 mesh sieves,
60The sterilization of Co--r x ray irradiation x, dosage 10Kgy, standby.
2. by the accurate weighing Rhizoma Curcumae Longae of prescription, break into coarse powder (particle diameter 5mm), add 1.6 times of amounts of 75% ethanol, soak into lh, reflux, extract, three times is used 75% ethanol triplication at every turn, extracts lh, and extracting solution merges, ethanol is reclaimed in decompression, low temperature, be condensed into fluid extract (1g crude drug/ml), standby.
3. by the accurate weighing Artemisia anethoicles Mattf of prescription, add 6 times of water gagings, soak into lh, steam distillation 2.5 hours extracts volatile oil, and is standby.(medicinal residues after the distillation and mother solution adding decocting in water extract partly to boil together and carry.)
4. press the accurate weighing Radix Et Rhizoma Rhei of recipe quantity, Periostracum Cicadae, Radix Puerariae, Rhizoma Alismatis, Hirudo, Fructus Crataegi, Semen Cassiae, Radix Polygoni Multiflori, Fructus Hordei Germinatus decoction pieces, adding 2 times of water gagings soaked 30 minutes, add the Herba Artemisiae Scopariae of having carried volatile oil, add water, boil and carry 3 times, be respectively 2,1,1 hours, and added 12 times of amounts of water for the first time, (wherein 1 times of water gaging is (a 3) mother solution) second and third time respectively adds 12 times of water gagings, merging filtrate, concentrate under reduced pressure at low temperature to relative density 1.25-1.30 (65 ℃) heat is surveyed) thick paste, 60 ℃ of forced air dryings are pulverized, cross 100 mesh sieves, standby.
5. with (1) Xiang Fenyu (4) powder mix homogeneously,, cross 14 mesh sieves and granulate with (a 2) fluid extract system soft material, dry below 50 ℃, cross 16 mesh sieve granulate, spray (3) volatile oil, mixing.Carry out assay and health examination, make preparation after qualified.
Below by effect experiment beneficial effect of the present invention is described.Test used medicine for the medicine that the method according to the embodiment of the invention 1 prepares, be called lifting blood fat regulating capsule positive control to use a kind of Western medicine blood lipid-lowering medicine gemfibrozil, experimental result sees Table 1-5.
The specific embodiment: further specify the present invention by the following examples
The preparation of embodiment 1 capsule
Bombyx Batryticatus 100 gram Radix Et Rhizoma Rhei 50 gram Rhizoma Curcumae Longaes 70 grams
Periostracum Cicadae 40 gram Radix Puerariaes 150 gram Rhizoma Alismatis 100 grams
Herba Artemisiae Scopariae chamber 150 gram Hirudos, 70 Keshan short, bristly hair or beards, 120 grams
The Semen Cassiae 100 gram Radixs Polygoni Multiflori 100 gram Fructus Hordei Germinatus 30 grams
Above raw material is made 1000 [preparation technologies] 1 of lifting blood fat regulating capsule altogether by the accurate weighing Bombyx Batryticatus of prescription, and cold drying is pulverized, and crosses 100 mesh sieves,
60C
o--the sterilization of r x ray irradiation x, dosage 10Kgy is standby.2 by the accurate weighing Rhizoma Curcumae Longae of prescription, breaks into coarse powder (particle diameter 5mm), adds 1.6 times of amounts of 75% ethanol, soaks into lh, reflux, extract, three times is used 75% ethanol triplication at every turn, extracts lh, and extracting solution merges, ethanol is reclaimed in decompression, low temperature, be condensed into fluid extract (1g crude drug/ml), standby.3 by the accurate weighing Artemisia anethoicles Mattf of prescription, adds 6 times of water gagings, soaks into lh, and steam distillation 2.5 hours extracts volatile oil, and is standby.(medicine short, bristly hair or beard after the distillation and mother solution adding decocting in water extract partly to boil together and carry.) 4 press the accurate weighing Radix Et Rhizoma Rhei of recipe quantity, Periostracum Cicadae, Radix Puerariae, Rhizoma Alismatis, Hirudo, Fructus Crataegi, Semen Cassiae, Radix Polygoni Multiflori, Fructus Hordei Germinatus decoction pieces, adding 2 times of water gagings soaked 30 minutes, add the Herba Artemisiae Scopariae of having carried volatile oil, add water, boil and carry 3 times, be respectively 2,1,1 hours, and added 12 times of amounts of water for the first time, (wherein 1 times of water gaging is (a 3) mother solution) second and third time respectively adds 12 times of water gagings, merging filtrate, concentrate under reduced pressure at low temperature to relative density 1.25-1.30 (65 ℃) heat is surveyed) thick paste, 60 ℃ of forced air dryings are pulverized, cross 100 mesh sieves, standby.5 with (1) Xiang Fenyu (4) powder mix homogeneously, with (a 2) fluid extract system soft material, crosses 14 mesh sieves and granulate, dry below 50 ℃, crosses 16 mesh sieve granulate, sprays (3) volatile oil, mixing.Carry out assay and health examination, pack No. 1 capsule into promptly after qualified.
The preparation of embodiment 2 tablets
Bombyx Batryticatus 100 gram Radix Et Rhizoma Rhei 50 gram Rhizoma Curcumae Longaes 70 grams
Periostracum Cicadae 40 gram Radix Puerariaes 150 gram Rhizoma Alismatis 100 grams
Herba Artemisiae Scopariae chamber 150 gram Hirudos, 70 Keshan short, bristly hair or beards, 120 grams
The Semen Cassiae 100 gram Radixs Polygoni Multiflori 100 gram Fructus Hordei Germinatus 30 grams
Above raw material is made 1000 [preparation technologies] 1 of lifting blood fat regulating capsule altogether by the accurate weighing Bombyx Batryticatus of prescription, and cold drying is pulverized, and crosses 100 mesh sieves,
60C
o--the sterilization of r x ray irradiation x, dosage 10Kgy is standby.2 by the accurate weighing Rhizoma Curcumae Longae of prescription, breaks into coarse powder (particle diameter 5mm), adds 1.6 times of amounts of 75% ethanol, soaks into lh, reflux, extract, three times is used 75% ethanol triplication at every turn, extracts lh, and extracting solution merges, ethanol is reclaimed in decompression, low temperature, be condensed into fluid extract (1g crude drug/ml), standby.3 by the accurate weighing Artemisia anethoicles Mattf of prescription, adds 6 times of water gagings, soaks into lh, and steam distillation 2.5 hours extracts volatile oil, and is standby.(medicine short, bristly hair or beard after the distillation and mother solution adding decocting in water extract partly to boil together and carry.) 4 press the accurate weighing Radix Et Rhizoma Rhei of recipe quantity, Periostracum Cicadae, Radix Puerariae, Rhizoma Alismatis, Hirudo, Fructus Crataegi, Semen Cassiae, Radix Polygoni Multiflori, Fructus Hordei Germinatus decoction pieces, adding 2 times of water gagings soaked 30 minutes, add the Herba Artemisiae Scopariae of having carried volatile oil, add water, boil and carry 3 times, be respectively 2,1,1 hours, and added 12 times of amounts of water for the first time, (wherein 1 times of water gaging is (a 3) mother solution) second and third time respectively adds 12 times of water gagings, merging filtrate, concentrate under reduced pressure at low temperature to relative density 1.25-1.30 (65 ℃) heat is surveyed) thick paste, 60 ℃ of forced air dryings are pulverized, cross 100 mesh sieves, standby.5 with (1) Xiang Fenyu (4) powder mix homogeneously, with (a 2) fluid extract system soft material, crosses 14 mesh sieves and granulate, dry below 50 ℃, crosses 16 mesh sieve granulate, sprays (3) volatile oil, adds magnesium stearate 10g, mixing, and tabletting is made 1000 altogether.
The preparation of embodiment 3 granules
Bombyx Batryticatus 100 gram Radix Et Rhizoma Rhei 50 gram Rhizoma Curcumae Longaes 70 grams
Periostracum Cicadae 40 gram Radix Puerariaes 150 gram Rhizoma Alismatis 100 grams
Herba Artemisiae Scopariae chamber 150 gram Hirudos, 70 Keshan short, bristly hair or beards, 120 grams
The Semen Cassiae 100 gram Radixs Polygoni Multiflori 100 gram Fructus Hordei Germinatus 30 grams
Above raw material is made 1000 [preparation technologies] 1 of lifting blood fat regulating capsule altogether by the accurate weighing Bombyx Batryticatus of prescription, and cold drying is pulverized, and crosses 100 mesh sieves,
60C
o--the sterilization of r x ray irradiation x, dosage 10Kgy is standby.2 by the accurate weighing Rhizoma Curcumae Longae of prescription, breaks into coarse powder (particle diameter 5mm), adds 1.6 times of amounts of 75% ethanol, soaks into lh, reflux, extract, three times is used 75% ethanol triplication at every turn, extracts lh, and extracting solution merges, ethanol is reclaimed in decompression, low temperature, be condensed into fluid extract (1g crude drug/ml), standby.3 by the accurate weighing Artemisia anethoicles Mattf of prescription, adds 6 times of water gagings, soaks into lh, and steam distillation 2.5 hours extracts volatile oil, and is standby.(medicine short, bristly hair or beard after the distillation and mother solution adding decocting in water extract partly to boil together and carry.) 4 press the accurate weighing Radix Et Rhizoma Rhei of recipe quantity, Periostracum Cicadae, Radix Puerariae, Rhizoma Alismatis, Hirudo, Fructus Crataegi, Semen Cassiae, Radix Polygoni Multiflori, Fructus Hordei Germinatus decoction pieces, adding 2 times of water gagings soaked 30 minutes, add the Herba Artemisiae Scopariae of having carried volatile oil, add water, boil and carry 3 times, be respectively 2,1,1 hours, and added 12 times of amounts of water for the first time, (wherein 1 times of water gaging is (a 3) mother solution) second and third time respectively adds 12 times of water gagings, merging filtrate, concentrate under reduced pressure at low temperature to relative density 1.25-1.30 (65 ℃) heat is surveyed) thick paste, 60 ℃ of forced air dryings are pulverized, cross 100 mesh sieves, standby.5 with (1) Xiang Fenyu (4) powder mix homogeneously, adds sucrose 100g, with (a 2) fluid extract system soft material, crosses 14 mesh sieves and granulate, dry below 50 ℃, crosses 16 mesh sieve granulate, sprays (3) volatile oil, mixing.Pack in the bag, make 250 bags altogether.One. the lifting blood fat regulating capsule to high lipid food bring out serum lipids in rats influence table 1 lifting blood fat regulating capsule to the influence of rat fat and lipoprotein (x ± S, n=10)
(mmol/l) TC/HDL--TC TC TC LDL-C HDL-C Normal group-1.58 ± 0.22 1.56 ± 0.22 0.58 ± 0.18 0.99 ± 0.17 0.28 ± 0.12 6.02 ± 2.53 hyperlipidemia model group-1.54 ± 0.24 10.03 ± 5.45 Δ Δ, 0.92 ± 0.45 Δ, 9.55 ± 5.25 Δ Δs 0.22 ± 0.12 48.50 ± 27.19 Δ Δ lifting blood fat regulating capsule, 0.3 1.55 ± 0.20 3.02 ± 0.98**, 0.22 ± 0.04**, 2.38 ± 0.91**, 0.53 ± 0.31**, 6.45 ± 2.49** of blood fat (mmol/l) group (g/kg) after the blood fat administration before the dosed administration
0.6 1.58 ± 0.18 3.02 ± 0.52**, 0.27 ± 0.12**, 2.40 ± 0.55**, 0.49 ± 0.08**, 6.26 ± 1.44** gemfibrozil group, 0.2 1.53 ± 0.19 2.49 ± 1.27**, 0.34 ± 0.21**, 1.26 ± 0.47**, 0.73 ± 0.34**, 3.62 ± 1.06** compares with the normal control group: Δ P＜0.05 Δ Δ P＜0.01, compare with model group: * P＜0.05 * * P＜0.01 table 2 lifting blood fat regulating capsule to the influence of hemorheology of rat (x ± S, n=10)
Whole blood viscosity group dosage plasma viscosity is crossed erythrocyte electrophoretic time (second)
The g/kg height is cut (200S
-1) low (40S that cuts
-1) 6.04 ± 0.65 8.00 ± 0.92 2.10 ± 0.08 17.82 ± 2.89 rising-falling tone fat controls organize 0.3 5.99 ± 0.76 7.71 ± 1.15 2.10 ± 0.22 16.5 ± 1.17 to normal control group--5.31 ± 1.07 7.77 ± 1.13 1.63 ± 0.15 15.56 ± 1.89 hyperlipidemia model group--
0.6 5.85 ± 0.71 7.60 ± 1.00 1.95 ± 0.18 17.55 ± 1.22 gemfibrozil groups 0.2 5.97 ± 0.60 6.98 ± 2.52 2.02 ± 0.19 16.44 ± 2.00 table 3 lifting blood fat regulating capsule is to influence (x ± S, n=10) the group dosage TC TG of hyperlipidemia rats liver lipid content
(g/kg) (mmol/l) (mmol/l) Normal group--the control of 0.11 ± 0.04 0.16 ± 0.07 hyperlipidemia model group, 0.58 ± 0.14 Δ Δ, 0.44 ± 0.19 Δ rising-falling tone fat glue, 0.3 0.31 ± 0.09**, 0.26 ± 0.13* capsule is organized 0.6 0.39 ± 0.15*, 0.33 ± 0.16 CI-719 group, 0.2 0.31 ± 0.13**, 0.14 ± 0.08** and is compared Δ P＜0.05 Δ Δ P＜0.01 with Normal group; Compare * P＜0.05**P＜0.01 two with model group. the lifting blood fat regulating capsule to the therapeutic action table, 4 lifting blood fat regulating capsule of Hyperlipidemia Rabbits to the hemorheological impact of Hyperlipidemia Rabbits (x ± S, n=10)
Whole blood viscosity group dosage erythrocyte electrophoretic time (second) plasma viscosity
(g/kg) height is cut (200S
-1) low (40S that cuts
-1) normal control group 4.20 ± 0.82 5.09 ± 1.03 1.59 ± 0.05 15.90 ± 1.67 hyperlipidemia model group 4.36 ± 0.47 5.44 ± 0.52 1.78 ± 0.19 17.81 ± 0.95 rising-falling tone fat capsule for treating group 0.15 3.98 ± 0.27 4.86 ± 0.73 1.67 ± 0.11 16.90 ± 1.08
0.30 3.77 ± 0.42 4.87 ± 0.66 1.71 ± 0.12 16.68 ± 1.22 gemfibrozil groups, 0.13 3.78 ± 0.63 4.67 ± 0.86 1.70 ± 0.11 16.07 ± 2.23 table 5 lifting blood fat regulating capsule is to influence (x ± S, n=10) the group dosage TC TG of hyperlipemia man rabbit liver lipid content
(g/kg) (mmol/l) (mmol/l) normal control group-0.11 ± 0.08 0.24 ± 0.10 hyperlipidemia model group-1.21 ± 0.16 Δ Δ, 0.48 ± 0.12 Δ Δ rising-falling tone fat capsule for treating group, 0.15 0.95 ± 0.31*, 0.34 ± 0.23*
0.30 0.69 ± 0.18**, 0.28 ± 0.12** gemfibrozil group, 0.13 0.56 ± 0.26**, 0.28 ± 0.10** compares Δ Δ P＜0.01 with the normal control group, compare * P＜0.05 * * P＜0.01 with model group
Claims (10)
1. Chinese medicine preparation that prevents and/or treats hyperlipemia, it is characterized in that, make Bombyx Batryticatus 50-200 part Radix Et Rhizoma Rhei 25-100 part Rhizoma Curcumae Longae 35-140 part Periostracum Cicadae 20-80 part Radix Puerariae 75-300 part Rhizoma Alismatis 50-200 part Herba Artemisiae Scopariae 75-300 part Hirudo 35-140 part Fructus Crataegi 60-240 part Semen Cassiae 50-200 part Radix Polygoni Multiflori 50-200 part Fructus Hordei Germinatus 15-60 part by following Chinese medicine raw materials by weight proportion.
2. the Chinese medicine preparation of claim 1, it is characterized in that, make Bombyx Batryticatus 75-133 part Radix Et Rhizoma Rhei 37-66 part Rhizoma Curcumae Longae 52-93 part Periostracum Cicadae 30-53 part Radix Puerariae 112-200 part Rhizoma Alismatis 75-133 part Herba Artemisiae Scopariae 112-200 part Hirudo 52-93 part Fructus Crataegi 90-160 part Semen Cassiae 75-133 part Radix Polygoni Multiflori 75-133 part Fructus Hordei Germinatus 22-40 part by following Chinese medicine raw materials by weight proportion.
3. the Chinese medicine preparation of claim 2, it is characterized in that, make 30 parts in 100 parts of Fructus Hordei Germinatus of 100 parts of Radix Polygoni Multiflori of 120 parts of Semen Cassiaes of 70 portions of Fructus Crataegis of 150 portions of Hirudos of 100 portions of Herba Artemisiae Scopariaes of 150 portions of Rhizoma Alismatis of 40 parts of Radix Puerariaes of 70 portions of Periostracum Cicadaes of 50 portions of Rhizoma Curcumae Longaes of 100 parts of Radix Et Rhizoma Rhei of Bombyx Batryticatus by following Chinese medicine raw materials by weight proportion.
4. the Chinese medicine preparation of claim 1-3 is to be fit to medicinal various dosage forms.
5. the Chinese medicine preparation of claim 4 is tablet, capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop, drop pill.
6. the Chinese medicine preparation of claim 4 is capsules.
7. the Chinese medicine preparation of claim 1 prevents and/or treats application in the medicine of hyperlipemia in preparation.
8. the preparation method of the Chinese medicine preparation of claim 1 is characterized in that, may further comprise the steps:
A. Bombyx Batryticatus, cold drying is pulverized, sieves,
B. Rhizoma Curcumae Longae breaks into coarse powder, and add ethanol and soak into, reflux, extract,, the extracting solution decompression recycling ethanol is condensed into fluid extract,
C. Artemisia anethoicles Mattf adds water infiltration, and steam distillation extracts volatile oil,
D. Radix Et Rhizoma Rhei, Periostracum Cicadae, Radix Puerariae, Rhizoma Alismatis, Hirudo, Fructus Crataegi, Semen Cassiae, Radix Polygoni Multiflori, Fructus Hordei Germinatus decoction pieces are soaked, and add the Herba Artemisiae Scopariae of having carried volatile oil, and add decocting in water and carry, merging filtrate, concentrate under reduced pressure at low temperature, drying are pulverized, sieve,
E. with (a) Xiang Fenyu (d) powder mix homogeneously, with (b) fluid extract system soft material, the granulation of sieving, drying, granulate sprays (c) volatile oil, and mixing is made preparation.
9. the preparation method of claim 8 is characterized in that, uses cobalt 60 radiation sterilizations behind the Bombyx Batryticatus crushing screening.
10. the preparation method of claim 8 is characterized in that, Rhizoma Curcumae Longae is refluxed after adding ethanol, refluxes altogether three times.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1319588C (en) * | 2005-04-18 | 2007-06-06 | 张静 | Theory and medicine for treating high blood fat, fatty liver, liver fibrosis and preparation method |
| CN1325088C (en) * | 2005-03-14 | 2007-07-11 | 张广东 | Oral administration liquor for reducing blood fat |
| CN103445116A (en) * | 2013-09-15 | 2013-12-18 | 宁波市江东农茹生物科技有限公司 | Healthcare radix puerariae nutrition powder with blood fat regulating effect |
| CN104225473A (en) * | 2014-09-22 | 2014-12-24 | 殷永洲 | Traditional Chinese medicine tablet for eliminating hyperlipemia |
| CN104435585A (en) * | 2015-01-03 | 2015-03-25 | 孟红琳 | Traditional Chinese medicine composition for treating phlegm stagnation middle energizer type hyperlipemia |
| CN104825882A (en) * | 2015-05-15 | 2015-08-12 | 张家港市五湖新材料技术开发有限公司 | Pharmaceutical composition for reducing blood lipid |
| CN105661542A (en) * | 2016-01-19 | 2016-06-15 | 吉林金恒制药股份有限公司 | Lipid-reducing healthcare oil |
| CN107693623A (en) * | 2017-10-27 | 2018-02-16 | 路望培 | A kind of Chinese medicine for reducing blood lipid |
-
2003
- 2003-03-31 CN CN 03121268 patent/CN1232279C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1325088C (en) * | 2005-03-14 | 2007-07-11 | 张广东 | Oral administration liquor for reducing blood fat |
| CN1319588C (en) * | 2005-04-18 | 2007-06-06 | 张静 | Theory and medicine for treating high blood fat, fatty liver, liver fibrosis and preparation method |
| CN103445116A (en) * | 2013-09-15 | 2013-12-18 | 宁波市江东农茹生物科技有限公司 | Healthcare radix puerariae nutrition powder with blood fat regulating effect |
| CN104225473A (en) * | 2014-09-22 | 2014-12-24 | 殷永洲 | Traditional Chinese medicine tablet for eliminating hyperlipemia |
| CN104435585A (en) * | 2015-01-03 | 2015-03-25 | 孟红琳 | Traditional Chinese medicine composition for treating phlegm stagnation middle energizer type hyperlipemia |
| CN104825882A (en) * | 2015-05-15 | 2015-08-12 | 张家港市五湖新材料技术开发有限公司 | Pharmaceutical composition for reducing blood lipid |
| CN105661542A (en) * | 2016-01-19 | 2016-06-15 | 吉林金恒制药股份有限公司 | Lipid-reducing healthcare oil |
| CN107693623A (en) * | 2017-10-27 | 2018-02-16 | 路望培 | A kind of Chinese medicine for reducing blood lipid |
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| Publication number | Publication date |
|---|---|
| CN1232279C (en) | 2005-12-21 |
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Address after: 1266 No. 330052 Nanchang Huiren Jiangxi economic and Technological Development Zone Avenue. Patentee after: JIANGXI HUIREN PHARMACEUTICAL CO.,LTD. Address before: 330043 No. 1189, Yingbin Avenue, Nanchang, Jiangxi Patentee before: Jiangxi Huiren Pharmaceutical Co.,Ltd. |
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