CN104547237A - Traditional Chinese medicinal composition for treating diabetes and method for preparing traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for treating diabetes and method for preparing traditional Chinese medicinal composition Download PDFInfo
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- CN104547237A CN104547237A CN201410819174.0A CN201410819174A CN104547237A CN 104547237 A CN104547237 A CN 104547237A CN 201410819174 A CN201410819174 A CN 201410819174A CN 104547237 A CN104547237 A CN 104547237A
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Abstract
The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicinal composition for treating diabetes and a method for preparing the traditional Chinese medicinal composition. The composition includes the following traditional Chinese medicinal materials, which are used as raw materials, in parts by weight: 8-26 parts of astragalus membranaceus, 1-14 parts of snake gourd fruit, 4-13 parts of atractylodes, 2-10 parts of radix rehmanniae, 1-10 parts of poria cocos, 1-12 parts of Chinese angelica, 2-10 parts of gorgon Euryale seeds, 1-10 parts of dodder, 1-8 parts of folium eriobotryae, 1-8 parts of agastache rugosus, 2-14 parts of hawthorn, 2-14 parts of mulberries and 1-8 parts of toosendan fruit. The traditional Chinese medicinal composition provided by the invention is strong in synergism, and can greatly improve the diabetic symptom, delay the development of diabetes, and reduce the incidence of complications.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of diabetes and preparation method thereof.
Background technology
The metabolic disease of diabetes to be one group with hyperglycemia be feature.Hyperglycemia be then due to defect of insulin secretion or its biological agent impaired, or both have concurrently and cause.Long-standing hyperglycemia during diabetes, causes various tissue, particularly eye, kidney, heart, blood vessel, neural chronic lesion, dysfunction.
At present, the medicine for the treatment of diabetes is a lot, but large drug is expensive, and medical expense is high.Treat still based on chemical synthetic drug, as sulfonamides, biguanides, glucosidase inhibitor, Lie Nai and euglycemic agent etc.Right chemical classes antidiabetic drug long-term taking is not only comparatively large to liver, injury of kidney, and easily produces drug resistance.
Chinese medicine ancient books and records describe the Chinese medicine much with blood sugar lowering curative effect, and as bavin dredges Radix Rehmanniae drink, Herba Artemisiae Scopariae Decoction, XIAOYAO POWDER, LIUWEI DIHUANG TANG etc., so the general curative effect of these medicines is on the low side.
Summary of the invention
The object of the invention is the defect existed for overcoming prior art, providing that a kind of good effect, effective percentage are high, raw material sources is sufficient, the Chinese medicine composition of low-cost treatment diabetes and preparation method thereof.
The Chinese medicine composition for the treatment of diabetes of the present invention is that crude drug prepares by the Chinese medicine of following parts by weight:
Radix Astragali 8-26 Fructus Trichosanthis 1-14 Rhizoma Atractylodis Macrocephalae 4-13 Radix Rehmanniae 2-10
Poria 1-10 Radix Angelicae Sinensis 1-12 Semen Euryales 2-10 Semen Cuscutae 1-10
Folium Eriobotryae 1-8 Herba Pogostemonis 1-8 Fructus Crataegi 2-14 Fructus Mori 2-14
Fructus Toosendan 1-8.
Preferably, the Chinese medicine composition for the treatment of diabetes of the present invention is that crude drug prepares by the Chinese medicine of following parts by weight:
The Radix Astragali 14 Fructus Trichosanthis 8 Rhizoma Atractylodis Macrocephalae 8 Radix Rehmanniae 6 Poria 4
Radix Angelicae Sinensis 6 Semen Euryales 6 Semen Cuscutae 4 Folium Eriobotryae 2 Herba Pogostemonis 3
Fructus Crataegi 6 Fructus Mori 6 Fructus Toosendan 3.
The present invention treats the preparation of the Chinese medicine composition of diabetes, can make the multiple dosage forms such as granule, tablet, capsule, pill, oral liquid, powder.
The pharmaceutical preparation of Chinese medicine composition of the present invention comprises following steps:
(1) take Semen Cuscutae, the Radix Rehmanniae, Folium Eriobotryae and Semen Euryales, dry, pulverize, make 100-200 order fine powder;
(2) take the Radix Astragali, Fructus Trichosanthis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Angelicae Sinensis, Herba Pogostemonis, Fructus Crataegi, Fructus Mori and Fructus Toosendan, dry, pulverize into coarse powder;
(3) by coarse powder prepared by step (2), add 5-8 times amount water soaking 1-2 hour, decoct 1-3 hour; Filter, filtering residue adds 2-5 times of water gaging, decocts 1-2 hour; Filter, merge twice filtrate, it is the thick paste of 1.20-1.30 that filtrate is concentrated into relative density at 60 DEG C, drying under reduced pressure, crosses 100-200 mesh sieve, obtain uniform fine powder after pulverizing;
(4) conventional pharmaceutical preparation is prepared into after fine powder mix homogeneously step (1) and step (3) made.
Verify that Chinese medicine composition of the present invention has following advantage compared with existing medicine through clinical experiment:
1) the present invention significantly can improve the symptom of diabetes, can also delay the development of diabetes, reduces the generation of complication.
2) Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, has no adverse reaction and toxic and side effects
3) Chinese medicine composition synergism of the present invention is strong, and taking dose is little, can allow rapidly in glucostasis ground normal range of patients with NIDDM, significantly improve the compliance of diabetics, and improve the quality of life of patient.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
eXAMPLE l
Prescription:
Radix Astragali 14kg Fructus Trichosanthis 8kg Rhizoma Atractylodis Macrocephalae 8kg Radix Rehmanniae 6kg Poria 4kg
Radix Angelicae Sinensis 6kg Semen Euryales 6kg Semen Cuscutae 4kg Folium Eriobotryae 2kg Herba Pogostemonis 3kg
Fructus Crataegi 6kg Fructus Mori 6kg Fructus Toosendan 3kg.
Preparation method:
(1) take Semen Cuscutae, the Radix Rehmanniae, Folium Eriobotryae and Semen Euryales, dry, pulverize, make 150 order fine powders;
(2) take the Radix Astragali, Fructus Trichosanthis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Angelicae Sinensis, Herba Pogostemonis, Fructus Crataegi, Fructus Mori and Fructus Toosendan, dry, pulverize into coarse powder;
(3) by coarse powder prepared by step (2), add 6 times amount water soaking 1 hour, decoct 3 hours; Filter, filtering residue adds 4 times of water gagings, decocts 2 hours; Filter, merge twice filtrate, it is the thick paste of 1.22 that filtrate is concentrated into relative density at 60 DEG C, drying under reduced pressure, crosses 150 mesh sieves, obtain uniform fine powder after pulverizing;
(4) capsule is prepared into after fine powder mix homogeneously step (1) and step (3) made.
embodiment 2
Prescription:
Radix Astragali 10kg Fructus Trichosanthis 4kg Rhizoma Atractylodis Macrocephalae 8kg Radix Rehmanniae 4kg Poria 4kg
Radix Angelicae Sinensis 4kg Semen Euryales 8kg Semen Cuscutae 6kg Folium Eriobotryae 4kg Herba Pogostemonis 4kg
Fructus Crataegi 4kg Fructus Mori 10kg Fructus Toosendan 4kg.
Preparation method
(1) take Semen Cuscutae, the Radix Rehmanniae, Folium Eriobotryae and Semen Euryales, dry, pulverize, make 100 order fine powders;
(2) take the Radix Astragali, Fructus Trichosanthis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Angelicae Sinensis, Herba Pogostemonis, Fructus Crataegi, Fructus Mori and Fructus Toosendan, dry, pulverize into coarse powder;
(3) by coarse powder prepared by step (2), add 8 times amount water soaking 1 hour, decoct 3 hours; Filter, filtering residue adds 5 times of water gagings, decocts 1 hour; Filter, merge twice filtrate, it is the thick paste of 1.22 that filtrate is concentrated into relative density at 60 DEG C, drying under reduced pressure, crosses 100 mesh sieves, obtain uniform fine powder after pulverizing;
(4) tablet is prepared into after fine powder mix homogeneously step (1) and step (3) made.
embodiment 3
Prescription:
Radix Astragali 20kg Fructus Trichosanthis 4kg Rhizoma Atractylodis Macrocephalae 8kg Radix Rehmanniae 4kg Poria 8kg
Radix Angelicae Sinensis 10kg Semen Euryales 8kg Semen Cuscutae 6kg Folium Eriobotryae 6kg Herba Pogostemonis 4kg
Fructus Crataegi 4kg Fructus Mori 10kg Fructus Toosendan 4kg.
Preparation method
(1) take Semen Cuscutae, the Radix Rehmanniae, Folium Eriobotryae and Semen Euryales, dry, pulverize, make 200 order fine powders;
(2) take the Radix Astragali, Fructus Trichosanthis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Angelicae Sinensis, Herba Pogostemonis, Fructus Crataegi, Fructus Mori and Fructus Toosendan, dry, pulverize into coarse powder;
(3) by coarse powder prepared by step (2), add 6 times amount water soaking 2 hours, decoct 2 hours; Filter, filtering residue adds 4 times of water gagings, decocts 1 hour; Filter, merge twice filtrate, it is the thick paste of 1.26 that filtrate is concentrated into relative density at 60 DEG C, drying under reduced pressure, crosses 200 mesh sieves, obtain uniform fine powder after pulverizing;
(4) granule is prepared into after fine powder mix homogeneously step (1) and step (3) made.
embodiment 4
Prescription:
Radix Astragali 18kg Fructus Trichosanthis 12kg Rhizoma Atractylodis Macrocephalae 8kg Radix Rehmanniae 8kg Poria 4kg
Radix Angelicae Sinensis 4kg Semen Euryales 8kg Semen Cuscutae 6kg Folium Eriobotryae 6kg Herba Pogostemonis 4kg
Fructus Crataegi 6kg Fructus Mori 6kg Fructus Toosendan 4kg.
Preparation method
(1) take Semen Cuscutae, the Radix Rehmanniae, Folium Eriobotryae and Semen Euryales, dry, pulverize, make 120 order fine powders;
(2) take the Radix Astragali, Fructus Trichosanthis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Angelicae Sinensis, Herba Pogostemonis, Fructus Crataegi, Fructus Mori and Fructus Toosendan, dry, pulverize into coarse powder;
(3) by coarse powder prepared by step (2), add 5 times amount water soaking 1 hour, decoct 1 hour; Filter, filtering residue adds 2 times of water gagings, decocts 1 hour; Filter, merge twice filtrate, it is the thick paste of 1.20 that filtrate is concentrated into relative density at 60 DEG C, drying under reduced pressure, crosses 120 mesh sieves, obtain uniform fine powder after pulverizing;
(4) capsule is prepared into after fine powder mix homogeneously step (1) and step (3) made.
clinical data
2010 to 2014, the clinical report of 150 routine patients with NIDDMs of the present invention's treatment was as follows.
physical data
150 routine patients with NIDDMs, through Western medicine diagnose, all meet the ADA(U.S. in 2010
diabetesassociation)
diabetesdiagnostic criteria, wherein man 87 example, female 63 example, 62.2 ± 9.2 years old age, the course of disease, 4.4 ± 2.1 years.
therapeutic Method
Give capsule prepared by embodiment 1, every day 3 times, each 4.30 days courses for the treatment of.
Treat and observe soreness of the waist and knees before and after all patient treatments after one month, fatigue and weak, dry mouth and throat, the clinical symptoms such as nocturia improve situation.Fasting glucose (FPG), glycolated hemoglobin (HbA1c), fasting insulin (FINS) before treatment, after treatment.
, criterion of therapeutical effect
Effective: clinical symptoms is improved obviously, soreness of the waist and knees, fatigue and weak, dry mouth and throat, nocturia etc. disappear or substantially disappear, blood sugar level fluctuation is within normal range, blood pressure≤128/80mmHg, 24h urine protein < 30mg, blood urea nitrogen and creatinine are all down to normal level.
Effective: clinical symptom relief, soreness of the waist and knees, fatigue and weak, dry mouth and throat, nocturia etc. be improved significantly, fasting glucose controls desirable, and fluctuation of blood pressure is at about 140/90mmHg, 24h urine protein and blood urea nitrogen creatinine all have decline, but do not take a turn for the better completely.
Invalid: clinical symptoms is improved not obvious, blood pressure and blood glucose decline without decline or have but undesirable, and 24h urine protein quantitation and blood urea nitrogen creatinine all do not decline, or decline and do not reach effective standard.
statistical procedures
Data acquisition SPSS16.0 software carries out statistical analysis.
result
before and after 5.1 treatments, blood glucose, glycolated hemoglobin and blood insulin compare
Before and after treatment, blood glucose, glycolated hemoglobin and fasting insulin compare in table 1.
Table 1 treatment front and back FBG, HbAlc and FINS compare (
)
Remarks:
*expression is compared with before treatment, P < 0.01.
After the treatment of 1 course for the treatment of, patient FBG, HbAlc, FINS decline before all comparatively treating, pole significant difference (P < 0.01) is had with before treatment, visible medicine of the present invention significantly can reduce the level of blood glucose, glycolated hemoglobin and blood insulin, improves old-aged diabetic's insulin resistant.
treatment curative effect
5.2.1, after the treatment of 1 course for the treatment of, patients with NIDDM clinical symptoms significantly alleviates, the transference cures such as soreness of the waist and knees, fatigue and weak, dry mouth and throat, nocturia.
5.2.2 after the treatment of 1 course for the treatment of, 150 patients with NIDDMs: effective: 98 examples, account for 65.3%; Effective 48, account for 32.0%; Invalid 4 examples, account for 2.7%, total effective rate is 97.3%.
5.2.3, after the treatment of 1 course for the treatment of, 150 patients with NIDDMs, have no 1 routine untoward reaction.
Claims (4)
1. treat a Chinese medicine composition for diabetes, it is characterized in that, described Chinese medicine composition is that crude drug is prepared from by the Chinese medicine of following parts by weight:
Radix Astragali 8-26 Fructus Trichosanthis 1-14 Rhizoma Atractylodis Macrocephalae 4-13 Radix Rehmanniae 2-10
Poria 1-10 Radix Angelicae Sinensis 1-12 Semen Euryales 2-10 Semen Cuscutae 1-10
Folium Eriobotryae 1-8 Herba Pogostemonis 1-8 Fructus Crataegi 2-14 Fructus Mori 2-14
Fructus Toosendan 1-8.
2. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that, described Chinese medicine composition is that crude drug is prepared from by the Chinese medicine of following parts by weight:
The Radix Astragali 14 Fructus Trichosanthis 8 Rhizoma Atractylodis Macrocephalae 8 Radix Rehmanniae 6 Poria 4
Radix Angelicae Sinensis 6 Semen Euryales 6 Semen Cuscutae 4 Folium Eriobotryae 2 Herba Pogostemonis 3
Fructus Crataegi 6 Fructus Mori 6 Fructus Toosendan 3.
3. the Chinese medicine composition for the treatment of diabetes according to claim 1 and 2, is characterized in that, the preparation of described Chinese medicine composition is granule, tablet, capsule, pill, oral liquid or powder.
4. the Chinese medicine composition for the treatment of diabetes according to claim 3, is characterized in that, the preparation method of described Chinese medicine composition, comprises following steps:
(1) take Semen Cuscutae, the Radix Rehmanniae, Folium Eriobotryae and Semen Euryales, dry, pulverize, make 100-200 order fine powder;
(2) take the Radix Astragali, Fructus Trichosanthis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Angelicae Sinensis, Herba Pogostemonis, Fructus Crataegi, Fructus Mori and Fructus Toosendan, dry, pulverize into coarse powder;
(3) by coarse powder prepared by step (2), add 5-8 times amount water soaking 1-2 hour, decoct 1-3 hour; Filter, filtering residue adds 2-5 times of water gaging, decocts 1-2 hour; Filter, merge twice filtrate, it is the thick paste of 1.20-1.30 that filtrate is concentrated into relative density at 60 DEG C, drying under reduced pressure, crosses 100-200 mesh sieve, obtain uniform fine powder after pulverizing;
(4) conventional pharmaceutical preparation is prepared into after fine powder mix homogeneously step (1) and step (3) made.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106266618A (en) * | 2016-09-12 | 2017-01-04 | 四川聚豪生物科技有限公司 | A kind of for endo-medicine treating diabetes and preparation method thereof |
CN107582844A (en) * | 2017-09-07 | 2018-01-16 | 成都兴倍加生物科技有限责任公司 | A kind of pill medicine for treating diabetes and preparation method thereof |
-
2014
- 2014-12-25 CN CN201410819174.0A patent/CN104547237A/en active Pending
Non-Patent Citations (2)
Title |
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莫娜等: "中医药治疗2型糖尿病胰岛素抵抗用药分析", 《陕西中医》 * |
陈弼沧等: "杨叔禹运用补脾益气法治疗糖尿病经验", 《辽宁中医杂志》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106266618A (en) * | 2016-09-12 | 2017-01-04 | 四川聚豪生物科技有限公司 | A kind of for endo-medicine treating diabetes and preparation method thereof |
CN107582844A (en) * | 2017-09-07 | 2018-01-16 | 成都兴倍加生物科技有限责任公司 | A kind of pill medicine for treating diabetes and preparation method thereof |
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