CN104984297A - Application of pharmaceutical composition in preparation of drugs for treating amenorrhea - Google Patents
Application of pharmaceutical composition in preparation of drugs for treating amenorrhea Download PDFInfo
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Abstract
The invention discloses an application of a pharmaceutical composition in the preparation of drugs for treating amenorrhea, and belongs to the technical field of traditional Chinese medicine. The pharmaceutical composition is composed of the following raw materials in parts by weight: 5 to 30 parts of folium artemisia argyi extract, 3 to 9 parts of corydalis tuber, 6 to 12 parts of Chinese angelica, 4 to 9 parts of toosendan fruit, 3 to 9 parts of combined spicebush, 6 to 12 parts of cortex moutan, 9 to 15 parts of malt, 5 to 12 parts of mulberry, 1 to 5 parts of cassia bark, 3 to 9 parts of green tangerine peel, 3 to 30 parts of rheum officinale, 6 to 15 parts of white peony root, 6 to 9 parts of curcuma rhizome, 9 to 30 parts of oyster, 3 to 9 parts of dry ginger, 9 to 15 parts of poria cocos, 6 to 12 parts of lily, 6 to 12 parts of fleece-flower root, 5 to 20 parts of mussel, and 1 to 10 parts of licorice. The pharmaceutical composition has the functions of activating blood circulation to remove blood stasis, regulating menstruation, relieving pains, nourishing yin, moistening the lung, clearing away heart fire, soothing the spirit, cooling blood, and removing toxicity, and has the advantages of scientific formula, quick effect, high cure rate, and low cost.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to the purposes of a kind of pharmaceutical composition in preparation treatment amenorrhea medicine.
Background technology
Amenorrhea is symptom common in gynaecopathia, can be caused by various different reason.Usually amenorrhea is divided into constitutional and Secondary cases two kinds.All persons that do not pass through yet over 18 years old are called primary amenorrhea; After menarche, in any time before normal menopause (gestation or age of sucking except), menstruation apolipsis is called secondary amenorrhea more than 6 months persons.Menstruation causes endometrical cycle to come off by the periodic adjustment of hypothalamic-pituitary-ovarian axis to be formed, therefore any organic or functional change occurred on the links in hypothalamus, hypophysis, ovary and reproductive tract particularly uterus, all may cause amenorrhea.Organic and the functional exception of other endocrine gland, also may affect menstruation so that amenorrhea occurs.
In recent years, along with the increase of life stress, just there is the phenomenon of amenorrhea too early in a lot of women before menopause.Amenorrhea is very large on the impact of women's physical and mental health.Amenorrhea is a kind of gynecological common disease, clinical manifestation: from ischomenia, association's abdominal distention and pain symptom is the most outstanding, the traditional Chinese medical science is thought: the generation of amenorrhea, void is had to have reality, many with empty person, reality person is few, void person is due to congenital defect or the fecund exhaustion due to sexual indulgence day after tomorrow, prolonged illness serious disease, improper diet and overtiredness, the factor such as to worry too much of being worried causes kidney qi weakness, or deficient qi and blood, or deficiency of YIN blood is dry, depletion of blood can under, and cause amenorrhea due to blood depletion, reality person is due to internal injury caused by excess of seven emotions or experience cold and heat damp or ferritic obesity, excessive phlegm wets more, cause qi depression to blood stasis, or stagnation of phlegm-damp, blockage of vessel, menses must not be descending and cause blood every amenorrhea.According to theory of Chinese medical science, for the pathogeny of amenorrhea, with depressed liver-energy dispersing and QI regulating, benefiting vital QI and blood, dispelling cold by warming the meridian, blood circulation promoting and blood stasis dispelling for the rule for the treatment of, carry out dialectical prescription compatibility, to reach the object for the treatment of both the principal and secondary aspects of a disease.At present, the medicine for the treatment of amenorrhea is also a lot, but there is the deficiencies such as curative effect instability, treatment time is long, side effect is large.
Chinese patent 201310308011.1 discloses a kind of Chinese medicine composition for the treatment of amenorrhea, this Chinese medicine composition is prepared from by the raw material of following weight portion: Radix Codonopsis 20-30 part, Radix Rehmanniae Preparata 20-30 part, Herba Epimedii 20-30 part, Folium Photiniae (Folium Photiniae serrulatae) 20-30 part, Radix Angelicae Sinensis 20-30 part, Radix Paeoniae Alba 20-30 part, Herba Leonuri 10-20 part, Radix Astragali 10-15 part, Cornu Cervi Degelatinatum 10-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Poria 5-15 part, Radix Rhapontici 5-15 part, Fructus Liquidambaris 5-15 part, Fructus Leonuri 5-15 part, Rhizoma Cyperi 5-15 part, Ramulus Cinnamomi 5-15 part, Fructus Lycii 5-15 part, Fructus Ligustri Lucidi 5-15 part, Semen Cuscutae 5-15 part, Fructus Rubi 5-15 part, Herba Ephedrae 5-15 part, Cortex Mori 5-15 part, Radix Achyranthis Bidentatae 5-15 part, Flos Carthami 5-15 part, Radix Bupleuri 5-15 part, Herba Lycopi 5-15 part, Radix Curcumae 5-15 part, Radix Glycyrrhizae 5-15 part, Eupolyphaga Seu Steleophaga 3-9 part, Hirudo 3-9 part, Radix Platycodonis 3-9 part, Rhizoma Chuanxiong 3-9 part.This Chinese medicine composition has stable curative effect, treatment time is short, side effect is little effect, but effect is not very remarkable in dispersing cold for relieving pain.
Summary of the invention
The technical problem to be solved in the present invention overcomes the deficiencies in the prior art, the purposes of a kind of pharmaceutical composition in preparation treatment amenorrhea medicine is provided, this pharmaceutical composition has effect of blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization and removing pathogenic heat from blood and toxic substance from the body, also there is compatibility science, curative effect is rapid, cure rate is high, low cost and other advantages.In addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.
Pharmaceutical composition of the present invention is prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi extract 5-30 part, Rhizoma Corydalis 3-9 part, Radix Angelicae Sinensis 6-12 part, Fructus Toosendan 4-9 part, Radix Linderae 3-9 part, Cortex Moutan 6-12 part, Fructus Hordei Germinatus 9-15 part, Fructus Mori 5-12 part, Cortex Cinnamomi 1-5 part, Pericarpium Citri Reticulatae Viride 3-9 part, Radix Et Rhizoma Rhei 3-30 part, Radix Paeoniae Alba 6-15 part, Rhizoma Curcumae 6-9 part, Concha Ostreae 9-30 part, Rhizoma Zingiberis 3-9 part, Poria 9-15 part, Bulbus Lilii 6-12 part, Radix Polygoni Multiflori 6-12 part, Mytilus 5-20 part and Radix Glycyrrhizae 1-10 part.
Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi extract 5 parts, Rhizoma Corydalis 3 parts, Radix Angelicae Sinensis 6 parts, Fructus Toosendan 4 parts, the Radix Linderae 3 parts, Cortex Moutan 6 parts, 9 parts, Fructus Hordei Germinatus, Fructus Mori 5 parts, Cortex Cinnamomi 1 part, 3 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 3 parts, the Radix Paeoniae Alba 6 parts, Rhizoma Curcumae 6 parts, Concha Ostreae 9 parts, Rhizoma Zingiberis 3 parts, 9 parts, Poria, Bulbus Lilii 6 parts, Radix Polygoni Multiflori 6 parts, Mytilus 5 parts and 1 part, Radix Glycyrrhizae.
Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi extract 30 parts, Rhizoma Corydalis 9 parts, Radix Angelicae Sinensis 12 parts, Fructus Toosendan 9 parts, the Radix Linderae 9 parts, Cortex Moutan 12 parts, 15 parts, Fructus Hordei Germinatus, Fructus Mori 12 parts, Cortex Cinnamomi 5 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 30 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Curcumae 9 parts, Concha Ostreae 30 parts, Rhizoma Zingiberis 9 parts, 15 parts, Poria, Bulbus Lilii 12 parts, Radix Polygoni Multiflori 12 parts, Mytilus 20 parts and 10 parts, Radix Glycyrrhizae.
Further, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi extract 20 parts, Rhizoma Corydalis 6 parts, Radix Angelicae Sinensis 10 parts, Fructus Toosendan 6 parts, the Radix Linderae 6 parts, Cortex Moutan 10 parts, 12 parts, Fructus Hordei Germinatus, Fructus Mori 9 parts, Cortex Cinnamomi 3 parts, 6 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 20 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Curcumae 8 parts, Concha Ostreae 20 parts, Rhizoma Zingiberis 6 parts, 10 parts, Poria, Bulbus Lilii 9 parts, Radix Polygoni Multiflori 9 parts, Mytilus 12 parts and 8 parts, Radix Glycyrrhizae.
Further, described pharmaceutical composition is made into capsule, tablet, powder, granule or pill.
Accordingly, the preparation method of described pharmaceutical composition comprises following step:
Step one: prepare Folium Artemisiae Argyi extract: take Folium Artemisiae Argyi, adds the vinegar of Folium Artemisiae Argyi weight 10-30%, fry 30-40min at 150-250 DEG C after, drying and crushing, obtain crushed material, add the alcoholic solution of mass concentration 30-60% in crushed material, the solid-liquid ratio of described crushed material and alcoholic solution is 1g:(10-50) mL, under reflux conditions extract 2-6h, filter, obtain filtrate, concentrated filtrate, drying, obtains Folium Artemisiae Argyi extract;
Step 2: take Rhizoma Corydalis, Radix Angelicae Sinensis, Fructus Toosendan, the Radix Linderae, Cortex Moutan, Fructus Hordei Germinatus, Fructus Mori, Cortex Cinnamomi, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Rhizoma Curcumae, Concha Ostreae, Rhizoma Zingiberis, Poria, Bulbus Lilii, Radix Polygoni Multiflori, Mytilus and Radix Glycyrrhizae, add the 5-10 water doubly of medical material gross weight, soak 30-60 minute, decoct 1-3 time, each 1-3 hour, filter, obtain and merging filtrate, filtrate is evaporated to the extractum of relative density 1.25-1.35 at 60 DEG C, adding ethanol to alcohol content is 70-90%(v/v), leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, mix with the Folium Artemisiae Argyi extract that step one obtains, stir, obtain pharmaceutical composition.
Source, the nature and flavor of the present invention's component used, return through and effect:
Folium Artemisiae Argyi: be the dried leaves of feverfew Chinese mugwort; Its nature and flavor acrid, bitter, warm, returns liver,spleen,kidney warp; Folium Artemisiae Argyi has the effects such as warming the meridian for stopping bleeding, dispersing cold for relieving pain, regulating menstruation are antiabortive, removing damp to relieve itching, dredge the meridian passage.
Rhizoma Corydalis: this product is the dry tuber of papaveraceae plant corydalis; Acrid in the mouth, hardship, warm in nature; Return liver, spleen channel; Invigorate blood circulation, promoting the circulation of QI, pain relieving.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica; Sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Inrigorating qi and promoting blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Fructus Toosendan: this product is the dry mature fruit of Meliaceae plant Fructus Toosendan; Bitter in the mouth, cold in nature; Return liver, small intestinal, urinary bladder channel; Soothing liver-QI promoting the circulation of QI to relieve pain.
The Radix Linderae: this product is the dried root of the canella Radix Linderae; Acrid in the mouth, warm in nature; Return lung, spleen, kidney, urinary bladder channel; Pleasant pain relieving, warming kidney for dispelling cold.
Cortex Moutan: this product is the dry root bark of ranunculaceae peony; Bitter in the mouth, pungent, cold nature; GUIXIN, liver, kidney channel; Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.
Fructus Hordei Germinatus: this product is that the mature fruit of grass Fructus Hordei Vulgaris obtains through drying of germinateing; Sweet in the mouth, property is put down; Return spleen, stomach warp; Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite.
Fructus Mori: this product is the mature fruit of mulberry; Sweet in the mouth acid, cold in nature; Enter lung, liver, kidney, large intestine channel; The liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, black hair improving eyesight, quench the thirst removing toxic substances, looks improving and the skin nourishing.
Cortex Cinnamomi: this product is the dry bark of canella Cortex Cinnamomi; Acrid in the mouth, sweet, extremely hot in nature; Return kidney, spleen, the heart, Liver Channel; Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.
Pericarpium Citri Reticulatae Viride: this product is the dry young fruit of rutaceae orange and variety thereof or the peel of immature fruit; Bitter in the mouth, pungent, warm in nature; Return liver, gallbladder, stomach warp; Soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.
Radix Et Rhizoma Rhei: this product is the dry root and rhizome of polygonaceae plant Radix Et Rhizoma Rhei; Bitter in the mouth, cold in nature; Return spleen, stomach, large intestine, liver, pericardium channel; Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae; Bitter in the mouth, acid, cold nature; Return liver, spleen channel; Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Rhizoma Curcumae: this product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae; Acrid in the mouth, hardship, warm in nature; Return liver, spleen channel; Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.
Concha Ostreae: this product is the shell of Ostreidae animal Concha Ostreae; Salty in the mouth, cold nature; Return liver, gallbladder, kidney channel; Tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.
Rhizoma Zingiberis: this product is the dry rhizome of zingiber; Acrid in the mouth, hot in nature; Return spleen, stomach, kidney, the heart, lung meridian; Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.
Poria: this product is the dry sclerotia of On Polyporaceae Poria; Sweet in the mouth, light, property is put down; GUIXIN, lung, spleen, kidney channel; Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
Bulbus Lilii: this product is the dry meat scale leaf of liliaceous plant Bulbus Lilii; Sweet in the mouth, cold in nature; GUIXIN, lung meridian; Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.
Radix Polygoni Multiflori: this product is the dried root of polygonum multiflorum thunb; Bitter in the mouth, sweet, puckery, warm in nature; Return liver, the heart, kidney channel; Removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.
Mytilus: this product is the shellfish meat of Mytilidae animal; Salty in the mouth, warm in nature; Enter liver, kidney channel; Invigorating the liver and kidney, benefiting essence-blood, disappear goiter.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Compared with prior art, the present invention has following technical advantage:
1, pharmaceutical composition of the present invention is compared with the medicine of other treatment amenorrhea, in blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization and removing pathogenic heat from blood and toxic substance from the body, has significant effect.
2, compared with the chemotherapeutic agent of Current therapeutic amenorrhea, pharmaceutical composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and pharmaceutical composition effect of the present invention is comprehensive, medication effect is better, efficiently solve the morbidity root of amenorrhea, and improve the quality of life of patient.
3, pharmaceutical composition of the present invention also has compatibility science, and curative effect is rapid, and cure rate is high, low cost and other advantages.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1:
Embodiment 1 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi extract 5 parts, Rhizoma Corydalis 3 parts, Radix Angelicae Sinensis 6 parts, Fructus Toosendan 4 parts, the Radix Linderae 3 parts, Cortex Moutan 6 parts, 9 parts, Fructus Hordei Germinatus, Fructus Mori 5 parts, Cortex Cinnamomi 1 part, 3 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 3 parts, the Radix Paeoniae Alba 6 parts, Rhizoma Curcumae 6 parts, Concha Ostreae 9 parts, Rhizoma Zingiberis 3 parts, 9 parts, Poria, Bulbus Lilii 6 parts, Radix Polygoni Multiflori 6 parts, Mytilus 5 parts and 1 part, Radix Glycyrrhizae.
Preparation method is as follows:
Step one: prepare Folium Artemisiae Argyi extract: take Folium Artemisiae Argyi, adds the vinegar of Folium Artemisiae Argyi weight 20%, fry 30min at 200 DEG C after, drying and crushing, obtain crushed material, add the alcoholic solution of mass concentration 40% in crushed material, the solid-liquid ratio of described crushed material and alcoholic solution is 1g:20mL, under reflux conditions extract 3h, filter, obtain filtrate, concentrated filtrate, drying, obtains Folium Artemisiae Argyi extract;
Step 2: take Rhizoma Corydalis, Radix Angelicae Sinensis, Fructus Toosendan, the Radix Linderae, Cortex Moutan, Fructus Hordei Germinatus, Fructus Mori, Cortex Cinnamomi, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Rhizoma Curcumae, Concha Ostreae, Rhizoma Zingiberis, Poria, Bulbus Lilii, Radix Polygoni Multiflori, Mytilus and Radix Glycyrrhizae, add the water of 5 times of medical material gross weight, soak 30 minutes, decoct 2 times, each 3 hours, filter, obtain and merging filtrate, filtrate is evaporated to the extractum of relative density 1.25 at 60 DEG C, adding ethanol to alcohol content is 80%(v/v), leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, mix with the Folium Artemisiae Argyi extract that step one obtains, stir, obtain the embodiment of the present invention 1 pharmaceutical composition.Add capsule and commonly use adjuvant, incapsulate in shell, obtain the capsule of the embodiment of the present invention 1 pharmaceutical composition.
embodiment 2:
Embodiment 2 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi extract 30 parts, Rhizoma Corydalis 9 parts, Radix Angelicae Sinensis 12 parts, Fructus Toosendan 9 parts, the Radix Linderae 9 parts, Cortex Moutan 12 parts, 15 parts, Fructus Hordei Germinatus, Fructus Mori 12 parts, Cortex Cinnamomi 5 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 30 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Curcumae 9 parts, Concha Ostreae 30 parts, Rhizoma Zingiberis 9 parts, 15 parts, Poria, Bulbus Lilii 12 parts, Radix Polygoni Multiflori 12 parts, Mytilus 20 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
embodiment 3:
Embodiment 3 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi extract 20 parts, Rhizoma Corydalis 6 parts, Radix Angelicae Sinensis 10 parts, Fructus Toosendan 6 parts, the Radix Linderae 6 parts, Cortex Moutan 10 parts, 12 parts, Fructus Hordei Germinatus, Fructus Mori 9 parts, Cortex Cinnamomi 3 parts, 6 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 20 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Curcumae 8 parts, Concha Ostreae 20 parts, Rhizoma Zingiberis 6 parts, 10 parts, Poria, Bulbus Lilii 9 parts, Radix Polygoni Multiflori 9 parts, Mytilus 12 parts and 8 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
embodiment 4:
Embodiment 4 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi extract 25 parts, Rhizoma Corydalis 7 parts, Radix Angelicae Sinensis 8 parts, Fructus Toosendan 6 parts, the Radix Linderae 7 parts, Cortex Moutan 10 parts, 13 parts, Fructus Hordei Germinatus, Fructus Mori 11 parts, Cortex Cinnamomi 3 parts, 7 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 24 parts, the Radix Paeoniae Alba 13 parts, Rhizoma Curcumae 7 parts, Concha Ostreae 21 parts, Rhizoma Zingiberis 5 parts, 13 parts, Poria, Bulbus Lilii 8 parts, Radix Polygoni Multiflori 9 parts, Mytilus 18 parts and 7 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
embodiment 5:
Embodiment 5 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi extract 22 parts, Rhizoma Corydalis 7 parts, Radix Angelicae Sinensis 8 parts, Fructus Toosendan 5 parts, the Radix Linderae 5 parts, Cortex Moutan 8 parts, 11 parts, Fructus Hordei Germinatus, Fructus Mori 11 parts, Cortex Cinnamomi 2 parts, 5 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 23 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Curcumae 7 parts, Concha Ostreae 24 parts, Rhizoma Zingiberis 7 parts, 11 parts, Poria, Bulbus Lilii 11 parts, Radix Polygoni Multiflori 9 parts, Mytilus 16 parts and 9 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
pharmaceutical composition of the present invention is on rat estrogen level impact experiment
1, experimental technique: get 60 female sd inbred rats, be divided into 5 groups at random, often organize 12, be respectively blank group, model group, low dose group, middle dosage group and high dose group, except blank group, rat is respectively organized to other and does bilateral oophorectomy, 3 months after operation, to each group of rat oral gavage administration, the normal saline of blank group and model group gavage equivalent, low dose group, middle dosage group and the corresponding medicine of high dose group gavage, medicine used is the pharmaceutical composition that embodiment 3 prepares, once a day, successive administration 30 days.Last administration is after 2 hours, and abdomen arterial blood extracting prepares serum, detects serum estradiol (E2) and follicle stimulating hormone (FSH) content, compare between organizing with test kit.
2, experimental result: as shown in table 1.
Table 1 experimental result
Note: compared with model group,
▲p < 0.05, compared with blank group,
★ ★p < 0.01.
As shown in Table 1, compared with blank group, model group follicle stimulating hormone and serum estradiol significantly reduce, and have extremely significant difference; Compared with model group, the follicle stimulating hormone of high, medium and low dosage group and serum estradiol have and improve more significantly, have the difference of significance, visible, pharmaceutical composition of the present invention obviously can raise rat blood serum estradiol and follicle stimulating hormone content, has certain rising effect to rat estrogen.
Because whether estrogen and menstruation are normally closely connected, therefore the number of estrogen all can have an impact to amenorrhea, by this experiment on the estrogenic impact of rat, can learn that pharmaceutical composition of the present invention tool in control estrogen has certain effect, experimental result shows, pharmaceutical composition of the present invention has certain rising effect to rat estrogen, visible, and pharmaceutical composition of the present invention has corresponding curative effect in treatment amenorrhea.
pharmaceutical composition of the present invention is to the improvement result of rat blood stasis models
1, test method: get 60 healthy SD rats, body weight 0.18kg-0.2kg, male and female half and half, are divided into 6 groups at random by body weight, often organize 10, be respectively: Normal group, model group, nutagrass flatsedge rhizome bolus by seven processes group, low dose group, middle dosage group and high dose group, gastric infusion respectively, successive administration 14 days, Normal group and model group gastric infusion 0.5%CMC, all the other pharmaceutical compositions preparing to the corresponding embodiment of the present invention 3, dosage is as shown in table 1.Administration the 13rd day, 14 days, except Normal group, all the other treated animals press 1mg/Kg subcutaneous injection adrenalin hydrochloride, 2 times/day, interval 4h, and after first time injection, animal is put into 15min in 4 DEG C of frozen water by 2h.Administration is got 4-5ml blood anticoagulant heparin on the 15th day and is measured blood rheology parameter, gets liver and to weigh conversion organ coefficient.
2, result of the test: as shown in table 2, table 3
Table 2 is on the impact of rat blood stasis models liver coefficient
Note: compare with Normal group,
▲ ▲ p < 0.01; Compared with model group
★p < 0.05,
★ ★p < 0.01.
The result statistics display of liver coefficient, model group compares with normal control, and liver coefficient significantly increases.And compare with model group, pharmaceutical composition of the present invention each dosage group basic, normal, high significantly reduce liver coefficient (
p<0.01), nutagrass flatsedge rhizome bolus by seven processes group compared with model group, can reduce significantly liver coefficient (
p<0.05), but effect not as good as pharmaceutical composition of the present invention.
Table 3 is on the impact of rat blood stasis models lectin from hemolymph
Note: compare with Normal group,
▲ p < 0.05,
▲ ▲ p < 0.01; Compared with model group
★p < 0.05,
★ ★p < 0.01.
As shown in Table 3, model group compares with normal control, the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have and significantly increase (
p<0.05).Compare with model group, pharmaceutical composition of the present invention each dosage group basic, normal, high all significantly or pole significantly reduce the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity, reduction amplitude amount effect relationship, wherein high dose group there were significant differences (
p<0.05).Under same experiment condition, nutagrass flatsedge rhizome bolus by seven processes group also reduces whole blood height cut index, the low cut index of whole blood, erythrocyte aggregation index, but its to the improvement effect of hemorheology index all not as good as pharmaceutical composition of the present invention.
Visible, pharmaceutical composition of the present invention in blood stasis removing with more excellent compared with existing medicine in reduction liver coefficient.Because amenorrhea is often because blockage of vessel, menses must not be descending and cause blood every amenorrhea, is therefore one of primary treatment principle according to theory of Chinese medical science blood circulation promoting and blood stasis dispelling.This experiment is by research pharmaceutical composition of the present invention to the improvement result of rat blood stasis models, and the symptom of blood stasis after simulating women's amenorrhea, draws its effect in blood stasis dispelling.Found by research, pharmaceutical composition of the present invention has good therapeutical effect for the blood stasis situation of rat, visible, and pharmaceutical composition of the present invention has significant effect in treatment women amenorrhea.
pharmaceutical composition of the present invention is to the observation of curative effect of amenorrhea clinical volunteers patient
One, diagnostic criteria
(1) over 18 one full year of life woman, menstruation is menophania person not yet, belongs to primary amenorrhea;
(2) woman has passed through and has interrupted more than 3 months persons, belongs to secondary amenorrhea;
(3) must differentiate mutually with physiological menolipsis such as trimester of pregnancy, age of sucking, menopause.
Two, criterion of therapeutical effect
(1) cure: menstrual onset, continuous more than 3 times menorrheas;
(2) effective: menstruation recovery is risen, but menstrual cycle is abnormal;
(3) invalid; Menstruation is risen not yet.
Three, clinical trial
1, physical data
360 selected amenorrhea clinical volunteers patients are divided into 6 groups at random, often organize 60 people, be respectively treatment A group, treatment B group, treatment C group, treatment D group, treatment E group and matched group, age is 18-45 year, respectively organizes the influence factor such as age, symptom, through statistical procedures, there was no significant difference, meets a point set condition.
2, Therapeutic Method
Treatment A group: take the capsule (0.2g*60 grain/bottle) that embodiment 1 prepares, every day 2 times, each 6, serve on 2 months;
Treatment B group: take the capsule (0.2g*60 grain/bottle) that embodiment 2 prepares, every day 2 times, each 6, serve on 2 months;
Treatment C group: take the capsule (0.2g*60 grain/bottle) that embodiment 3 prepares, every day 2 times, each 6, serve on 2 months;
Treatment D group: take the capsule (0.2g*60 grain/bottle) that embodiment 4 prepares, every day 2 times, each 6, serve on 2 months;
Treatment E group: take the capsule (0.2g*60 grain/bottle) that embodiment 5 prepares, every day 2 times, each 6, serve on 2 months;
Matched group: take pill for invigorating circulation of blood and regulating menstruation (Guangxi Wuzhou Sanhe Pharmaceutical Co., Ltd, accurate word Z45020639, the 9g*10 ball/box of traditional Chinese medicines), 1 ball, 2 times on the one, serve on 2 months.
3, therapeutic outcome, as shown in table 4.
Table 4 therapeutic effect
This test adopts pill for invigorating circulation of blood and regulating menstruation as a control group, and pill for invigorating circulation of blood and regulating menstruation is by Radix Angelicae Sinensis (processed with wine), Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Rhizoma Corydalis (vinegar system), Pericarpium Citri Reticulatae Viride (vinegar system), Fructus Aurantii (parched with bran), Colla Corii Asini (Pulvis concha Mactrae scalds), Rhizoma Cyperi (vinegar system), Flos Carthami, the Chinese medicines such as Cortex Moutan meticulously refine and form, and have blood circulation promoting regulates qi, the effect of clots absorbing regulating menstruation, by comparing with medicine composite for curing effect of the present invention, embody the curative effect of pharmaceutical composition of the present invention in treatment amenorrhea, make inventor surprisingly, treatment A group, treatment B group, treatment C group, the cure rate for the treatment of D group and treatment E group is all greater than 80%, and total effective rate is all greater than 90%, and much larger than cure rate and the total effective rate of matched group, wherein, the therapeutic effect for the treatment of C group is best, that is when containing Folium Artemisiae Argyi extract 20 parts in pharmaceutical composition of the present invention, Rhizoma Corydalis 6 parts, Radix Angelicae Sinensis 10 parts, Fructus Toosendan 6 parts, the Radix Linderae 6 parts, Cortex Moutan 10 parts, 12 parts, Fructus Hordei Germinatus, Fructus Mori 9 parts, Cortex Cinnamomi 3 parts, 6 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 20 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Curcumae 8 parts, Concha Ostreae 20 parts, Rhizoma Zingiberis 6 parts, 10 parts, Poria, Bulbus Lilii 9 parts, Radix Polygoni Multiflori 9 parts, when Mytilus 12 parts and 8 parts, Radix Glycyrrhizae, the effect for the treatment of amenorrhea is best, visible, pharmaceutical composition good effect of the present invention, and cure rate is high, can as the drug use for the treatment of amenorrhea.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.
Claims (6)
1. the purposes of a pharmaceutical composition in preparation treatment amenorrhea medicine, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi extract 5-30 part, Rhizoma Corydalis 3-9 part, Radix Angelicae Sinensis 6-12 part, Fructus Toosendan 4-9 part, Radix Linderae 3-9 part, Cortex Moutan 6-12 part, Fructus Hordei Germinatus 9-15 part, Fructus Mori 5-12 part, Cortex Cinnamomi 1-5 part, Pericarpium Citri Reticulatae Viride 3-9 part, Radix Et Rhizoma Rhei 3-30 part, Radix Paeoniae Alba 6-15 part, Rhizoma Curcumae 6-9 part, Concha Ostreae 9-30 part, Rhizoma Zingiberis 3-9 part, Poria 9-15 part, Bulbus Lilii 6-12 part, Radix Polygoni Multiflori 6-12 part, Mytilus 5-20 part and Radix Glycyrrhizae 1-10 part.
2. purposes as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi extract 5 parts, Rhizoma Corydalis 3 parts, Radix Angelicae Sinensis 6 parts, Fructus Toosendan 4 parts, the Radix Linderae 3 parts, Cortex Moutan 6 parts, 9 parts, Fructus Hordei Germinatus, Fructus Mori 5 parts, Cortex Cinnamomi 1 part, 3 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 3 parts, the Radix Paeoniae Alba 6 parts, Rhizoma Curcumae 6 parts, Concha Ostreae 9 parts, Rhizoma Zingiberis 3 parts, 9 parts, Poria, Bulbus Lilii 6 parts, Radix Polygoni Multiflori 6 parts, Mytilus 5 parts and 1 part, Radix Glycyrrhizae.
3. purposes as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi extract 30 parts, Rhizoma Corydalis 9 parts, Radix Angelicae Sinensis 12 parts, Fructus Toosendan 9 parts, the Radix Linderae 9 parts, Cortex Moutan 12 parts, 15 parts, Fructus Hordei Germinatus, Fructus Mori 12 parts, Cortex Cinnamomi 5 parts, 9 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 30 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Curcumae 9 parts, Concha Ostreae 30 parts, Rhizoma Zingiberis 9 parts, 15 parts, Poria, Bulbus Lilii 12 parts, Radix Polygoni Multiflori 12 parts, Mytilus 20 parts and 10 parts, Radix Glycyrrhizae.
4. purposes as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi extract 20 parts, Rhizoma Corydalis 6 parts, Radix Angelicae Sinensis 10 parts, Fructus Toosendan 6 parts, the Radix Linderae 6 parts, Cortex Moutan 10 parts, 12 parts, Fructus Hordei Germinatus, Fructus Mori 9 parts, Cortex Cinnamomi 3 parts, 6 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 20 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Curcumae 8 parts, Concha Ostreae 20 parts, Rhizoma Zingiberis 6 parts, 10 parts, Poria, Bulbus Lilii 9 parts, Radix Polygoni Multiflori 9 parts, Mytilus 12 parts and 8 parts, Radix Glycyrrhizae.
5. the purposes as described in any one of claim 1-4, is characterized in that, described pharmaceutical composition is made into capsule, tablet, powder, granule or pill.
6. the purposes as described in any one of claim 1-4, is characterized in that, the preparation method of described pharmaceutical composition comprises following step:
Step one: prepare Folium Artemisiae Argyi extract: take Folium Artemisiae Argyi, adds the vinegar of Folium Artemisiae Argyi weight 10-30%, fry 30-40min at 150-250 DEG C after, drying and crushing, obtain crushed material, add the alcoholic solution of mass concentration 30-60% in crushed material, the solid-liquid ratio of described crushed material and alcoholic solution is 1g:10-50mL, under reflux conditions extract 2-6h, filter, obtain filtrate, concentrated filtrate, drying, obtains Folium Artemisiae Argyi extract;
Step 2: take Rhizoma Corydalis, Radix Angelicae Sinensis, Fructus Toosendan, the Radix Linderae, Cortex Moutan, Fructus Hordei Germinatus, Fructus Mori, Cortex Cinnamomi, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Rhizoma Curcumae, Concha Ostreae, Rhizoma Zingiberis, Poria, Bulbus Lilii, Radix Polygoni Multiflori, Mytilus and Radix Glycyrrhizae, add the 5-10 water doubly of medical material gross weight, soak 30-60 minute, decoct 1-3 time, each 1-3 hour, filter, obtain and merging filtrate, filtrate is evaporated to the extractum of relative density 1.25-1.35 at 60 DEG C, adding ethanol to alcohol content is 70-90%(v/v), leave standstill 24 hours, get supernatant, ethanol is reclaimed in distilling under reduced pressure, dry, be ground into powder, mix with the Folium Artemisiae Argyi extract that step one obtains, stir, obtain pharmaceutical composition.
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| CN105214028A (en) * | 2015-09-29 | 2016-01-06 | 罗奕珺 | A kind of pharmaceutical composition is for the preparation of the purposes in treatment amenorrhea medicine |
| CN105362933A (en) * | 2015-11-18 | 2016-03-02 | 暨南大学 | Application of artemisia argyi-containing pharmaceutical composition in preparation of drug for treatment of amenorrhoea |
| CN105412829A (en) * | 2015-12-16 | 2016-03-23 | 叶宗耀 | Application of pharmaceutical composition containing argy wormwood leaves in preparation of amenorrhea treatment drug |
| CN105727229A (en) * | 2016-03-16 | 2016-07-06 | 烟台市蓝洋之草医药生物科技有限公司 | Application of pharmaceutical composition containing Chinese mugwort in preparing amenorrhea therapeutics |
| CN105727237A (en) * | 2016-03-16 | 2016-07-06 | 烟台市蓝洋之草医药生物科技有限公司 | Folium artemisiae argyi-containing pharmaceutical composition for treating amenorrhea |
| CN107198727A (en) * | 2017-05-24 | 2017-09-26 | 申翰昭 | A kind of pharmaceutical composition of beautifying face and moistering lotion promoting blood circulation for regulating menstruation and preparation method thereof |
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Inventor after: Lu Shifen Inventor before: Ding Feng |
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Application publication date: 20151021 |