CN105214028A - Application of a pharmaceutical composition in the preparation of medicines for treating amenorrhea - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to application of a pharmaceutical composition in preparation of a medicine for treating amenorrhea. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 6-12 parts of polygonum multiflorum, 5-13 parts of Chinese yam, 6-16 parts of radix ophiopogonis, 6-28 parts of folium artemisiae argyi, 5-8 parts of rhizoma corydalis, 6-11 parts of angelica sinensis, 5-8 parts of szechwan chinaberry fruit, 4-10 parts of combined spicebush root, 5-12 parts of cortex moutan, 10-14 parts of malt, 6-12 parts of mulberry, 4-8 parts of cinnamon, 4-8 parts of pericarpium citri reticulatae viride, 10-18 parts of rheum officinale, 6-16 parts of radix paeoniae alba, 7-14 parts of curcuma zedoary, 10-16 parts of oyster, 2-6 parts of dried ginger, 10-15 parts of poria cocos and 4-12 parts. The pharmaceutical composition has the effects of promoting blood circulation, removing blood stasis, regulating menstruation, relieving pain, nourishing yin, moistening lung, clearing heart fire, tranquilizing mind, cooling blood, and removing toxic substance, and also has the advantages of scientific compatibility, rapid curative effect, high cure rate, low cost, etc.

Description

Application of a pharmaceutical composition in the preparation of medicines for treating amenorrhea

technical field

The invention belongs to the field of traditional Chinese medicines, and in particular relates to the application of a pharmaceutical composition in the preparation of medicines for treating amenorrhea.

Background technique

Amenorrhea is a common symptom in gynecological diseases and can be caused by various reasons. Amenorrhea is usually divided into primary and secondary two. Those who have not menstruated after the age of 18 are called primary amenorrhea; those who have stopped menstruation for more than 6 months after menarche and at any time before normal menopause (except pregnancy or lactation) are called secondary amenorrhea . Menstruation is formed by the periodic regulation of the hypothalamus-pituitary-ovarian axis, resulting in the shedding of the endometrium cycle, so any organic or functional abnormalities in the hypothalamus, pituitary, ovary and reproductive tract, especially the uterus Changes may cause amenorrhea. Organic and functional abnormalities of other endocrine glands may also affect menstruation so that amenorrhea occurs.

In recent years, with the increase of life pressure, many women have premature amenorrhea before menopause. Amenorrhea has a great impact on women's physical and mental health. Amenorrhea is a common gynecological disease. The clinical manifestations are: from the cessation of menstruation, the symptoms of abdominal distension and pain are the most prominent. Traditional Chinese medicine believes that: the occurrence of amenorrhea is caused by deficiency and excess. Labor in the delivery room, chronic illness, fatigue from eating, worrying and worrying and other factors lead to weakness of kidney qi, or weakness of qi and blood, or deficiency of yin and dryness of blood, resulting in amenorrhea due to blood dryness. Or feel cold, heat and dampness evil or body obesity, phlegm and dampness, resulting in stagnation of qi and blood stasis, or blockage of phlegm and dampness, blocked arteries, and menstrual blood cannot descend, resulting in amenorrhea. According to the theory of traditional Chinese medicine, according to the pathogenesis of amenorrhea, the treatment principles are to soothe the liver and regulate qi, tonify qi and blood, warm the meridians and dispel cold, and activate blood to remove blood stasis. At present, there are many drugs for the treatment of amenorrhea, but there are shortcomings such as unstable curative effect, long treatment time, and large side effects.

Chinese patent 201310308011.1 discloses a traditional Chinese medicine composition for treating amenorrhea. 20-30 parts of leaves, 20-30 parts of angelica, 20-30 parts of white peony, 10-20 parts of motherwort, 10-15 parts of astragalus, 10-15 parts of antler cream, 5-15 parts of Atractylodes macrocephala, 5-15 parts of Poria cocos, 5-15 parts of Leulu, 5-15 parts of Passepartout, 5-15 parts of Fructus Chinensis, 5-15 parts of Rhizoma Cyperus, 5-15 parts of Guizhi, 5-15 parts of Lycium barbarum, 5-15 parts of Ligustrum lucidum 5-15 parts of dodder, 5-15 parts of raspberry, 5-15 parts of ephedra, 5-15 parts of Morus alba, 5-15 parts of Achyranthes bidentata, 5-15 parts of safflower, 5-15 parts of Bupleurum, 5-15 parts of Eupatorium, 5-15 parts of Curcuma, 5-15 parts of Licorice, 3-9 parts of Wood Beetle, 3-9 parts of Leech, 3-9 parts of Campanulaceae, and 3-9 parts of Chuanxiong. The traditional Chinese medicine composition has the effects of stable curative effect, short treatment time and small side effects, but the effect in expelling cold and relieving pain is not very significant.

Contents of the invention

The technical problem to be solved by the present invention is to provide a pharmaceutical composition used in the preparation of medicines for treating amenorrhea. The pharmaceutical composition has the effects of promoting blood circulation and removing blood stasis, regulating menstruation and relieving pain, nourishing yin and moistening lung, clearing heart and tranquilizing mind, cooling blood and detoxifying, It also has the advantages of scientific compatibility, rapid curative effect, high cure rate and low cost. In addition, the present invention also provides a corresponding manufacturing process to make the pharmaceutical composition into a convenient and easy-to-use preparation under the premise of ensuring the curative effect.

The pharmaceutical composition of the present invention is prepared from the following raw materials in parts by weight:

Polygonum multiflorum 6-12 parts, Chinese yam 5-13 parts, Ophiopogon japonicus 6-16 parts, Artemisia argyi 6-28 parts, Corydalis 5-8 parts, Angelica 6-11 parts, Toosendan 5-8 parts, Wuyao 4-10 parts 5-12 parts of paeonol, 10-14 parts of malt, 6-12 parts of mulberry, 4-8 parts of cinnamon, 4-8 parts of green skin, 10-18 parts of rhubarb, 6-16 parts of white peony, 7-14 parts of curcuma 10-16 parts of oysters, 2-6 parts of dried ginger, 10-15 parts of Poria cocos and 4-12 parts of licorice.

Further, the pharmaceutical composition is prepared from the following raw materials in parts by weight:

6 parts of Polygonum multiflorum, 5 parts of Chinese yam, 6 parts of Ophiopogon japonicus, 6 parts of mugwort leaves, 5 parts of Yanhusuo, 6 parts of angelica, 5 parts of Toosendan, 4 parts of black medicine, 5 parts of paeonol, 10 parts of malt, 6 parts of mulberry, 4 parts of cinnamon 4 parts of green skin, 10 parts of rhubarb, 6 parts of white peony root, 7 parts of curcuma, 10 parts of oyster, 2 parts of dried ginger, 10 parts of Poria cocos and 4 parts of licorice.

Further, the pharmaceutical composition is prepared from the following raw materials in parts by weight:

12 parts of Polygonum multiflorum, 3 parts of Chinese yam, 16 parts of Ophiopogon japonicus, 28 parts of Artemisia argyi, 8 parts of Yanhusuo, 11 parts of Angelica sinensis, 8 parts of Toosendan, 10 parts of black medicine, 12 parts of paeonol, 14 parts of malt, 12 parts of mulberry, cinnamon 8 parts, 8 parts of green bark, 18 parts of rhubarb, 16 parts of white peony root, 14 parts of curcuma, 16 parts of oyster, 6 parts of dried ginger, 15 parts of Poria cocos and 12 parts of licorice.

Further, the pharmaceutical composition is prepared from the following raw materials in parts by weight:

10 parts of Polygonum multiflorum, 8 parts of Chinese yam, 12 parts of Ophiopogon japonicus, 18 parts of mugwort leaves, 6 parts of Yanhusuo, 8 parts of angelica, 6 parts of Toosendan, 6 parts of black medicine, 10 parts of paeonol, 12 parts of malt, 8 parts of mulberry, cinnamon 6 parts, 6 parts of green bark, 16 parts of rhubarb, 12 parts of white peony root, 8 parts of curcuma, 10 parts of oyster, 4 parts of dried ginger, 12 parts of Poria cocos and 8 parts of licorice.

Further, the pharmaceutical composition is made into capsules, tablets, powders, granules or pills.

Correspondingly, the preparation method of described pharmaceutical composition comprises the following steps:

S1 Take Ophiopogon japonicus and pulverize it, place it in a supercritical carbon dioxide extraction device, add ethanol with a concentration of 75-85% 2-3 times the total amount of Ophiopogon japonicus powder, adjust the carbon dioxide flow rate to 16-22L/h, and extract the pressure to 18- 25MPa, the extraction temperature is 55-65°C, the extraction time is 2-3h, and separated under reduced pressure to obtain the Ophiopogon japonicus extract;

S2 Take Polygonum multiflorum, Yam, Artemisia argyi, Corydalis, Angelica, Toosendan, Cinnamon, Paeonol, Malt, Mulberry, Cinnamon, Qingpi, Rhubarb, Radix Paeoniae Alba, Curcuma, Oyster, Dried Ginger, Poria cocos and Licorice, add the above crude 10-15 times the total amount of the powder, heated and refluxed for extraction 2-3 times, each time for 2-3 hours, filtered, and combined filtrates to obtain a water extract;

S3 Concentrate the water extract obtained in step S2 under reduced pressure to an extract with a relative density of 1.15-1.25 at 60°C, add 7-10% of the total amount of the above extract at 55-65°C to a mass fraction of 0.8-1.2 % chitosan colloidal solution, stirred for 5-10 minutes, stood at room temperature for 12-24 hours, centrifuged at 1000-1200r/min for 10-15 minutes, took the supernatant, and mixed with the Ophiopogon japonicus extract obtained in step S1 , and concentrated under reduced pressure to an extract with a relative density of 1.20-1.35 measured at 60 ° C, that is, too.

The source, nature and flavor, meridian distribution and efficacy of the components used in the present invention:

Polygonum Polygoni Multiflori: This product is the dry root tuber of Polygonum Polygoni Multiflori Polygonum Polygonum; taste bitter, sweet, astringent, warm in nature; returns to liver, heart, and kidney channels; detoxifies, eliminates carbuncles, moistens the intestines and laxes the bowels.

Yam: It is the dried rhizome of yam, a plant of Dioscoreaceae; sweet and flat; it returns to the spleen, lung, and kidney meridian; it nourishes the spleen, nourishes the lung, strengthens the kidney, and benefits the essence.

Ophiopogon japonicus: the root of perennial evergreen herbaceous plant belonging to the genus Liliaceae; sweet, slightly bitter, slightly cold; Guixin, lung, and stomach meridian; nourishing yin and promoting body fluid, moistening lung and clearing heart.

Artemisia argyi: the dry leaf of Artemisia argyi; its nature and flavor are pungent, bitter, and warm, and it returns to the liver, spleen, and kidney meridians; Artemisia argyi has the functions of warming the meridians to stop bleeding, dispelling cold and relieving pain, regulating menstruation and preventing fetus, dehumidifying and relieving itching, dredging meridian and activating collaterals, etc. effect.

Corydalis Corydalis: This product is the dried tuber of Corydalis Corydalis of Poppyaceae; pungent, bitter, warm in nature; returns to liver and spleen meridians; promotes blood circulation, sharpens qi, and relieves pain.

Angelica: This product is the dried root of Angelica sinensis of Umbelliferae; sweet, pungent, warm in nature; returns to the liver, heart, and spleen meridians; invigorates qi and blood circulation, regulates menstruation and relieves pain, moistens the intestines and relieves constipation.

Toosendan: This product is the dry ripe fruit of Toosendan of Meliaceae; bitter in taste, cold in nature; returns to liver, small intestine, and bladder meridians; relieves liver, promotes qi and relieves pain.

Wuyao: This product is the dry root tuber of Lauraceae plant Wuyao; pungent in taste, warm in nature; returns to lung, spleen, kidney, and bladder meridian; smoothes qi to relieve pain, warms kidney and dispels cold.

Cortex paeonol: This product is the dry root bark of the Ranunculaceae plant peony; bitter, pungent, slightly cold in nature; Guixin, liver, and kidney channels; clearing away heat and cooling blood, promoting blood circulation and removing blood stasis.

Malt: This product is obtained by germinating and drying the mature fruit of barley, a grass family plant; it is sweet in taste and flat in nature; it returns to the spleen and stomach meridians;

Mulberry: This product is the mature fruit of the mulberry tree; it tastes sweet and sour, and is cold in nature; it enters the lung, liver, kidney, and large intestine meridians; it nourishes the liver and kidney, promotes body fluid and moistens the intestines, blackens the eyes, quenches thirst and detoxifies, and beautifies the skin.

Cinnamon: This product is the dry bark of Cinnamon lauraceae plant; spicy, sweet, and hot in nature; it returns to the kidney, spleen, heart, and liver meridian; it nourishes fire and supports yang, ignites fire to the source, dispels cold and relieves pain, promotes blood circulation and stimulates menstrual flow.

Qingpi: This product is the dried young fruit of Rutaceae plant orange and its cultivars or the pericarp of immature fruit; bitter, pungent, warm in nature; returns to the liver, gallbladder, and stomach meridians; soothes the liver and breaks qi, eliminates accumulation and resolves stagnation.

Rhubarb: This product is the dried root and rhizome of rhubarb of Polygonaceae; bitter in taste, cold in nature; it returns to the spleen, stomach, large intestine, liver, and pericardium meridians; relieves heat and unblocks the intestines, cools blood and detoxifies, expels blood stasis and stimulates menstrual flow.

Radix Paeoniae Alba: This product is the dry root of Paeoniae Alba, a plant of the family Ranunculaceae; bitter, sour, slightly cold in nature; returns to the liver and spleen meridians; calms the liver and relieves pain, nourishes blood and regulates menstruation, astringes yin and stops sweating.

Curcuma: This product is the dried rhizome of Zedoary Zingiberaceae; it is pungent, bitter, and warm in nature;

Oyster: This product is the shell of oyster, an animal of the Oyster family; it tastes salty and slightly cold in nature; it belongs to the liver, gallbladder, and kidney channels;

Dried Ginger: This product is the dried rhizome of Zingiber officinale; spicy in taste and hot in nature; it belongs to spleen, stomach, kidney, heart and lung meridian;

Poria cocos: This product is the dried sclerotia of Poria cocos fungus of the family Polyporaceae; sweet, light in taste, flat in nature; directs heart, lung, spleen and kidney meridian; diures water and eliminates dampness, invigorates the spleen and calms the heart.

Licorice: This product is the dried root of leguminous licorice, licorice inflating or licorice glabra. Sweet in taste, calm in nature; Guixin, lung, spleen, stomach meridians; invigorating spleen and replenishing qi, clearing heat and detoxification, eliminating phlegm and relieving cough, relieving spasm and relieving pain, harmonizing various medicines.

Compared with the prior art, the present invention has the following technical advantages:

1. Compared with other medicines for treating amenorrhea, the pharmaceutical composition of the present invention has remarkable effects in promoting blood circulation and removing blood stasis, regulating menstruation and relieving pain, nourishing yin and moistening lung, clearing heart and calming nerves, cooling blood and detoxifying.

2. Compared with the current chemotherapeutic drugs for the treatment of amenorrhea, the pharmaceutical composition of the present invention is a natural pure Chinese medicine preparation, and the adverse reactions and side effects are significantly reduced, and the pharmaceutical composition of the present invention has comprehensive effects, better drug treatment effect, and effectively solves the problem of The root cause of amenorrhea, and improve the quality of life of patients.

3. The pharmaceutical composition of the present invention also has the advantages of scientific compatibility, rapid curative effect, high cure rate and low cost.

detailed description

It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques discovered by the inventors to function well in the practice of the invention. However, many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.

Example 1:

The pharmaceutical composition of Example 1 of the present invention is prepared from the following raw materials in parts by weight: Polygonum multiflorum 6 parts, Chinese yam 5 parts, Ophiopogon japonicus 6 parts, Artemisia argyi 6 parts, Corydalis 5 parts, Angelica sinensis 6 parts, Toosendan 5 parts, 4 parts of black medicine, 5 parts of paeonol, 10 parts of malt, 6 parts of mulberry, 4 parts of cinnamon, 4 parts of green skin, 10 parts of rhubarb, 6 parts of white peony root, 7 parts of curcuma, 10 parts of oyster, 2 parts of dried ginger, and 10 parts of Poria cocos And licorice 4 parts.

The preparation method is as follows:

S1 Take Ophiopogon japonicus and pulverize it, put it in a supercritical carbon dioxide extraction device, add ethanol with a concentration of 75% twice the total amount of Ophiopogon japonicus, adjust the flow rate of carbon dioxide to 16L/h, extract pressure to 18MPa, and extract temperature to 55°C. The extraction time is 2 hours, and the Ophiopogon japonicus extract is obtained by separating under reduced pressure;

S2 Take Polygonum multiflorum, Yam, Artemisia argyi, Corydalis, Angelica, Toosendan, Cinnamon, Paeonol, Malt, Mulberry, Cinnamon, Qingpi, Rhubarb, Radix Paeoniae Alba, Curcuma, Oyster, Dried Ginger, Poria cocos and Licorice, add the above crude Heat reflux to extract 10 times the amount of the total amount of powder for 2 times, each time for 2 hours, filter, and combine the filtrates to obtain a water extract;

S3 concentrating the water extract obtained in step S2 under reduced pressure to an extract whose relative density is 1.15 at 60° C., adding a chitosan colloid solution with a mass fraction of 7% of the total amount of the extract at 55° C., which is 0.8%, Stir for 5 minutes, let stand at room temperature for 12 hours, centrifuge at 1000r/min for 10 minutes, take the supernatant, mix it with the Ophiopogon japonicus extract obtained in step S1, and concentrate under reduced pressure to 60°C to measure the extract with a relative density of 1.20. ointment, adding corresponding auxiliary materials to make capsules.

Example 2:

The pharmaceutical composition of Example 2 of the present invention is prepared from the following raw materials in parts by weight: Polygonum multiflorum 12 parts, Chinese yam 3 parts, Ophiopogon japonicus 16 parts, Artemisia argyi 28 parts, Corydalis 8 parts, Angelica sinensis 11 parts, Toosendan 8 parts, 10 parts of black medicine, 12 parts of paeonol, 14 parts of malt, 12 parts of mulberry, 8 parts of cinnamon, 8 parts of green skin, 18 parts of rhubarb, 16 parts of white peony root, 14 parts of curcuma, 16 parts of oyster, 6 parts of dried ginger, and 15 parts of Poria 12 parts and 12 parts of licorice.

S1 Take Ophiopogon japonicus and pulverize it, put it in a supercritical carbon dioxide extraction device, add ethanol with a concentration of 80% twice the total amount of Ophiopogon japonicus, adjust the carbon dioxide flow rate to 20L/h, the extraction pressure to 22MPa, and the extraction temperature to 60°C. The extraction time is 2 hours, and the Ophiopogon japonicus extract is obtained by separating under reduced pressure;

S2 Take Polygonum multiflorum, Yam, Artemisia argyi, Corydalis, Angelica, Toosendan, Cinnamon, Paeonol, Malt, Mulberry, Cinnamon, Qingpi, Rhubarb, Radix Paeoniae Alba, Curcuma, Oyster, Dried Ginger, Poria cocos and Licorice, add the above crude 12 times the amount of the total amount of the powder, heated and refluxed for extraction twice, each time for 2 hours, filtered, and the filtrates were combined to obtain a water extract;

S3 concentrates the water extract obtained in step S2 under reduced pressure to an extract whose relative density is 1.20 at 60° C., and adds a chitosan colloid solution with a mass fraction of 8% of the total amount of the extract above at 60° C., Stir for 8 minutes, let stand at room temperature for 18 hours, centrifuge at 1100r/min for 12 minutes, take the supernatant, mix it with the Ophiopogon japonicus extract obtained in step S1, and concentrate under reduced pressure to 60°C to measure the leached extract with a relative density of 1.30. Ointment, adding corresponding auxiliary materials, made into tablets.

Example 3:

The pharmaceutical composition of Example 3 of the present invention is prepared from the following raw materials in parts by weight: Polygonum multiflorum 10 parts, Chinese yam 8 parts, Ophiopogon japonicus 12 parts, Artemisia argyi 18 parts, Corydalis 6 parts, Angelica sinensis 8 parts, Toosendan 6 parts, 6 parts of black medicine, 10 parts of paeonol, 12 parts of malt, 8 parts of mulberries, 6 parts of cinnamon, 6 parts of green skin, 16 parts of rhubarb, 12 parts of white peony, 8 parts of curcuma, 10 parts of oysters, 4 parts of dried ginger, 12 parts of Poria cocos 8 parts and 8 parts of licorice.

S1 Take Ophiopogon japonicus and pulverize it, place it in a supercritical carbon dioxide extraction device, add 85% ethanol with a concentration three times the total amount of Ophiopogon japonicus, control the carbon dioxide flow rate to 22L/h, the extraction pressure to 25MPa, and the extraction temperature to 65°C. The extraction time is 3 hours, and the Ophiopogon japonicus extract is obtained by separating under reduced pressure;

S2 Take Polygonum multiflorum, Yam, Artemisia argyi, Corydalis, Angelica, Toosendan, Cinnamon, Paeonol, Malt, Mulberry, Cinnamon, Qingpi, Rhubarb, Radix Paeoniae Alba, Curcuma, Oyster, Dried Ginger, Poria cocos and Licorice, add the above crude 15 times of the total amount of the powder was heated and refluxed for extraction 3 times, each time for 3 hours, filtered, and the filtrates were combined to obtain a water extract;

S3 concentrates the water extract obtained in step S2 under reduced pressure to an extract whose relative density is 1.25 at 60° C., and adds a chitosan colloid solution with a mass fraction of 1.2% of the total amount of the extract at 65° C., Stir for 10 minutes, let stand at room temperature for 24 hours, centrifuge at 1200r/min for 15 minutes, take the supernatant, mix it with the Ophiopogon japonicus extract obtained in step S1, and concentrate under reduced pressure to 60°C to measure the leaching extract with a relative density of 1.35. Paste, add corresponding auxiliary materials, and make pills.

Observation of curative effect of pharmaceutical composition of the present invention on clinical volunteer patients with amenorrhea

1. Diagnostic criteria

(1) Women who are over 18 years old and who have not menstruated yet belong to primary amenorrhea;

(2) A woman who has already had menstruation but has interrupted it for more than 3 months belongs to secondary amenorrhea;

(3) It must be differentiated from physiological menopause such as pregnancy, lactation, and menopause.

2. Curative effect standard

(1) Cure: menstrual cramps, normal menstruation for more than 3 consecutive times;

(2) Effective: menstrual cramps resume, but the menstrual cycle is not normal;

(3) invalid; menstruation is still imminent.

3. Clinical trials

1. General Information

140 selected amenorrhea clinical volunteer patients were randomly divided into two groups, 70 people in each group, respectively, the treatment group and the control group, aged 18-48 years old, age, symptoms and other influencing factors in each group, after statistical processing, No significant difference, in line with the grouping conditions.

2. Treatment method

Treatment group: take the pill prepared in Example 3, each 6g, 2 times a day, for 2 months;

Control group: taking Huoxue Tiaojing Pills (Guangxi Wuzhou Sanhe Pharmaceutical Co., Ltd., Z45020639, 9g*10 pills/box), 1 pill at a time, twice a day, for 2 months.

3. Treatment results, as shown in Table 1:

The cure rate of the pharmaceutical composition of the present invention is all greater than 80%, and the total effective rate is all greater than 90%, far greater than the cure rate and total effective rate of the matched group. It can be seen that the pharmaceutical composition of the present invention has good curative effect, high cure rate, and can be used as Drug use to treat amenorrhea.

Since the present invention has been described by the above preferred embodiments, within the spirit and/or scope of the present invention, any replacement/or combination of the present invention to implement the present invention will be obvious to those skilled in the art , and is included in the present invention.

Claims (6)

1. pharmaceutical composition is for the preparation of the purposes in treatment amenorrhea medicine, and it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

Radix Polygoni Multiflori 6-12 part, Rhizoma Dioscoreae 5-13 part, Radix Ophiopogonis 6-16 part, Folium Artemisiae Argyi 6-28 part, Rhizoma Corydalis 5-8 part, Radix Angelicae Sinensis 6-11 part, Fructus Toosendan 5-8 part, Radix Linderae 4-10 part, Cortex Moutan 5-12 part, Fructus Hordei Germinatus 10-14 part, Fructus Mori 6-12 part, Cortex Cinnamomi 4-8 part, Pericarpium Citri Reticulatae Viride 4-8 part, Radix Et Rhizoma Rhei 10-18 part, Radix Paeoniae Alba 6-16 part, Rhizoma Curcumae 7-14 part, Concha Ostreae 10-16 part, Rhizoma Zingiberis 2-6 part, Poria 10-15 part and Radix Glycyrrhizae 4-12 part.

2. purposes as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

Radix Polygoni Multiflori 6 parts, Rhizoma Dioscoreae 5 parts, Radix Ophiopogonis 6 parts, Folium Artemisiae Argyi 6 parts, Rhizoma Corydalis 5 parts, Radix Angelicae Sinensis 6 parts, Fructus Toosendan 5 parts, the Radix Linderae 4, Cortex Moutan 5 parts, 10 parts, Fructus Hordei Germinatus, Fructus Mori 6 parts, Cortex Cinnamomi 4 parts, 4 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 10 parts, the Radix Paeoniae Alba 6 parts, Rhizoma Curcumae 7 parts, Concha Ostreae 10 parts, Rhizoma Zingiberis 2 parts, 10 parts, Poria and 4 parts, Radix Glycyrrhizae.

3. purposes as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

Radix Polygoni Multiflori 12 parts, Rhizoma Dioscoreae 3 parts, Radix Ophiopogonis 16 parts, Folium Artemisiae Argyi 28 parts, Rhizoma Corydalis 8 parts, Radix Angelicae Sinensis 11 parts, Fructus Toosendan 8 parts, the Radix Linderae 10 parts, Cortex Moutan 12 parts, 14 parts, Fructus Hordei Germinatus, Fructus Mori 12 parts, Cortex Cinnamomi 8 parts, 8 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 18 parts, the Radix Paeoniae Alba 16 parts, Rhizoma Curcumae 14 parts, Concha Ostreae 16 parts, Rhizoma Zingiberis 6 parts, 15 parts, Poria and 12 parts, Radix Glycyrrhizae.

4. purposes as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

Radix Polygoni Multiflori 10 parts, Rhizoma Dioscoreae 8 parts, Radix Ophiopogonis 12 parts, Folium Artemisiae Argyi 18 parts, Rhizoma Corydalis 6 parts, Radix Angelicae Sinensis 8 parts, Fructus Toosendan 6 parts, the Radix Linderae 6 parts, Cortex Moutan 10 parts, 12 parts, Fructus Hordei Germinatus, Fructus Mori 8 parts, Cortex Cinnamomi 6 parts, 6 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 16 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Curcumae 8 parts, Concha Ostreae 10 parts, Rhizoma Zingiberis 4 parts, 12 parts, Poria and 8 parts, Radix Glycyrrhizae.

5. the purposes as described in as arbitrary in claim 1-4, it is characterized in that, described pharmaceutical composition is made into capsule, tablet, powder, granule or pill.

6. the purposes as described in as arbitrary in claim 1-5, it is characterized in that, the preparation method of described pharmaceutical composition comprises following step:

S1 gets Radix Ophiopogonis and pulverizes, be placed in supercritical carbon dioxide extraction apparatus, adding Radix Ophiopogonis coarse powder total amount 2-3 times concentration is the ethanol of 75-85%, regulation and control carbon dioxide flow is 16-22L/h, extracting pressure is 18-25MPa, extraction temperature is 55-65 DEG C, and extraction time is 2-3h, and decompression separation obtains Radix Ophiopogonis extract;

S2 gets Radix Polygoni Multiflori, Rhizoma Dioscoreae, Folium Artemisiae Argyi, Rhizoma Corydalis, Radix Angelicae Sinensis, Fructus Toosendan, the Radix Linderae, Cortex Moutan, Fructus Hordei Germinatus, Fructus Mori, Cortex Cinnamomi, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Rhizoma Curcumae, Concha Ostreae, Rhizoma Zingiberis, Poria and Radix Glycyrrhizae and pulverizes, add water heating and refluxing extraction 2-3 time of above-mentioned coarse powder total amount 10-15 times amount, each 2-3 hour, filter, merging filtrate, obtains aqueous extract;

The aqueous extract that step S2 obtains by S3 is evaporated at 60 DEG C and surveys the extractum that relative density is 1.15-1.25, the mass fraction adding above-mentioned extractum total amount 7-10% at 55-65 DEG C is the chitosan gum liquid solution of 0.8-1.2%, stir 5-10 minute, leave standstill 12-24 hour at normal temperatures, the centrifugal 10-15 minute of 1000-1200r/min, gets supernatant, mixes with the Radix Ophiopogonis extract that step S1 obtains, and be evaporated at 60 DEG C and survey the extractum that relative density is 1.20-1.35, to obtain final product.