CN1600356A - Combination of Chinese traditional medicine for curing chronic pharyngitis and preparation method - Google Patents
Combination of Chinese traditional medicine for curing chronic pharyngitis and preparation method Download PDFInfo
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- CN1600356A CN1600356A CN 03160025 CN03160025A CN1600356A CN 1600356 A CN1600356 A CN 1600356A CN 03160025 CN03160025 CN 03160025 CN 03160025 A CN03160025 A CN 03160025A CN 1600356 A CN1600356 A CN 1600356A
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Abstract
A Chinese medicine for treating chronic pharyngolaryngitis is prepared from 7 Chinese-medicinal materials including red sage root, red peony root, honeysuckle flower, liquorice root, etc and the pharmacologically acceptable carrier. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of chronic pharyngitis, the invention still further relates to the preparation method of this Chinese medicine composition.
Background technology
Chronic pharyngitis is a common clinical, accounts for department of otorhinolaryngology out-patient's 20%.Symptoms such as clinical manifestation is bottleneck throat pain, drying, itch, cough.Have a medical check-up generally as seen: the bottleneck throat mucosa is kermesinus, the lateral pharyngeal band and the root of the tongue, retropharyneal folliculosis.This disease course of disease is long, and touching difficulty is the problem that the otorhinolaryngology doctor feels a delicacy about more always, brings very big misery to the patient.There have been many medicines to be used for the treatment of chronic pharyngitis in the prior art, as Herba Pileae Scriptae Tabellae, JIANMIN YINHOU PIAN, Dong ling cao tablet etc., the most close in patent documentation is CN11093263A, it discloses a kind of electuary for the treatment of pharyngitis, and it is to make with two precious flowers, Radix Scrophulariae, Folium Eriobotryae, Radix Platycodonis, Fructus Forsythiae, Radix Ophiopogonis, Fructus Mume, Radix Curcumae, Radix Glycyrrhizae and semen sterculiiae lychnophorae and Icing Sugar, dextrin.But the curative effect of these medicines can not be satisfactory.
Summary of the invention
Purpose of the present invention just provides a kind of Chinese medicine composition for the treatment of the chronic pharyngitis better efficacy.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
Chronic pharyngitis belongs to motherland's medical science " sore throat ", " globus hystericus " category, and ancient Chinese medicine doctor is discussed a lot of.Treatise on Febrile Diseases " SHAO YIN syndrome, two or three days, pharyngalgia person can with glycyrrhiza decoction, not poor and GUIGENG soup "; " treatise on blood trouble throat ": " so the family of losing blood, the card of pharyngalgia often being arranged ".The inventor is summing up on forefathers' experiential basis, and, think that the pathogenesis of primary disease is in conjunction with the progress of modern medicine and pharmacology: the invasion and attack of wind heat exopathogen, in throat, pathogen is controlled for a long time, stasis of blood resistance blood network blocks the card that the machine that closes forms gas, blood stasis resistance, loses smooth and cause QI-blood circulation, disorder of QI movement, water liquid stops and is phlegm retention, and gas, blood, expectorant, fire are tied in throat, sends out to be primary disease.
The inventor is at above-mentioned pathogenesis understanding to chronic pharyngitis, and the rule of treatment of having determined chronic pharyngitis is blood circulation promoting and blood stasis dispelling and pharynx-clearing throat-benefiting.
The Chinese medicine composition of treatment chronic pharyngitis of the present invention, effective ingredient that it is made by Chinese crude drug and/or pharmaceutically acceptable adjuvant are formed, wherein said effective ingredient is mainly made by following raw materials according: it is monarch drug that these raw materials are selected Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra blood circulation promoting and blood stasis dispelling for use, and Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae heat-clearing and toxic substances removing are ministerial drug.
The weight portion of these raw material consumptions is Radix Salviae Miltiorrhizae 4-7, Radix Paeoniae Rubra 2-3, Flos Lonicerae 1-3, Fructus Forsythiae 1-3 and Radix Scutellariae 1-3.
The weight portion of preferred these raw materials is Radix Salviae Miltiorrhizae 5-6, Radix Paeoniae Rubra 2-3, Flos Lonicerae 2-3, Fructus Forsythiae 1-2 and Radix Scutellariae 1-2.Optimum weight part of these raw materials is Radix Salviae Miltiorrhizae 6, Radix Paeoniae Rubra 3, Flos Lonicerae 3, Fructus Forsythiae 2 and Radix Scutellariae 2.
In another one preferred version of the present invention, can also add pharynx-clearing throat-benefiting Chinese crude drug such as Radix Platycodonis, Radix Glycyrrhizae etc. in the preparation raw materials of effective components.The consumption weight portion that they add is Radix Platycodonis 1-3 and Radix Glycyrrhizae 1-2.Preferably their consumption weight portion is Radix Platycodonis 1-2 and Radix Glycyrrhizae 1-1.5, and the best is Radix Platycodonis 2 and Radix Glycyrrhizae 1.2, and wherein Radix Glycyrrhizae is preferably Radix Glycyrrhizae Preparata.
In another preferred version of the present invention, can also add Chinese crude drug such as Radix Ophiopogonis, the Radix Rehmanniae etc. of nourishing yin effect in the preparation raw materials of effective components, better efficacy.The consumption weight portion that their add is 1-3 and Radix Rehmanniae 1-3 Radix Ophiopogonis.Be preferably 1-2 and Radix Rehmanniae 1-2 Radix Ophiopogonis, the best is Radix Ophiopogonis 2 and Radix Rehmanniae 2.
Preferred plan of the present invention is Radix Salviae Miltiorrhizae 6, Radix Paeoniae Rubra 3, Radix Platycodonis 2, Flos Lonicerae 3, Radix Scutellariae 2, Fructus Forsythiae 2, Radix Ophiopogonis 2, Radix Rehmanniae 2 and Radix Glycyrrhizae Preparata 1.2.
Modern pharmacological research confirms: Flos Lonicerae, Fructus Forsythiae have antibiotic, antivirus action; Radix Glycyrrhizae has corticoid effects such as antiinflammatory, and Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra have the enhancing immunity effect.Comprehensive clinical data, Chinese medicine composition of the present invention are at relief of symptoms, and eliminating the sign aspect has remarkable effect.
Effective ingredient of the present invention can become to use always peroral dosage form such as tablet, capsule, oral liquid, granule or the like with pharmaceutically acceptable preparing carriers.Effective ingredient of the present invention also can directly be ground into powder into powder and make powder.
The preparation method of Chinese medicine composition of the present invention is: get above medical material, decoct with water 3 times, collecting decoction filters, and filtrate decompression concentrates, put coldly, adding ethanol to the alcohol amount of containing is 70%, leaves standstill, and filters, filtrate decompression concentrates, reclaim ethanol after, be concentrated into relative density and be 1.25～1.35 extractum.Get extractum, spray drying gets extract powder.It is dry to granulate, promptly.
Chinese medicine composition of the present invention has blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing and nourishing yin and moistening dryness, evident in efficacy to chronic pharyngolaryngitis.
Usage and dosage is each 1 bag of adult, every bag of 10g, and every day twice, children's reduces by half or follows the doctor's advice.
Chinese medicine composition of the present invention is through the clinical verification determined curative effect.Be applied to the positive pharyngitis patient of clinical treatment 258 examples year January from May, 1994～1996, the curative effect final report is as follows:
1 clinical data
Select chronic pharyngitis patient 258 examples, wherein male 142 examples, women 116 examples, at 13～76 years old age, surplus the course of disease 1 month～20 year, all cases are all at morbidity state.
2 diagnostic criterias
The diagnostic criteria of chronic pharyngitis and criterion of therapeutical effect, we draft as follows in conjunction with document, data and clinical observation:
2.1 symptom pharyngalgia, dry pharynx, itching throat, pharynx foreign body sensation.
2.2 sign (1) pharyngeal mucosa chronic congestion; (2) pharynx rear wall, lymph follicle dress hypertrophy; The lateral pharyngeal band plumpness.
2 signs are arranged and have at least a person in the symptom promptly to examine and be chronic pharyngitis.
3 criterions of therapeutical effect
Healing symptom, sign all disappear.
The produce effects transference cure, sign has clear improvement.
Effective sx, sign does not have improvement.
Invalid symptom and sign does not all have change.
4 Therapeutic Method
Each 1 bag of oral Chinese medicine composition of the present invention, every day 3 times, 10 days was 1 course of treatment, the nonresponder can obey for 1 course of treatment again.
5 results
Whole 258 routine patients are through 1-2 course of therapy, and most patients' sings and symptoms significantly improves.Statistical result sees Table 1, table 2
Table 1
Transference cure % alleviates % does not have the total effectively % of the % of change
Pharyngalgia 169 78.24 37 17.12 10 4.62 206 95.37
Dry pharynx 182 90.54 5 2.48 14 6.96 187 93.03
Itching throat 104 61.17 58 34.11 8 4.70 162 95.29
Foreign body sensation 132 64.07 63 30.56 11 5.33 195 94.67
Table 2
Sign disappearance % alleviates % does not have the total effectively % of the % of change
Pharyngeal mucous membrane is slow
63 28.89 139 63.76 16 7.33 202 92.67
Property hyperemia
The pharynx rear wall drenches 21 8.13 164 63.56 73 28.29 185 71.69
Ba Zengsheng
Lateral pharyngeal band
11 4.43 150 60.48 87 35.08 161 64.82
Plump
Concrete embodiment
Embodiment 1
Take by weighing raw material Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Flos Lonicerae 10g, Radix Scutellariae 10g, Fructus Forsythiae 10g, with its pulverizing, grind into fine powder into powder, mix homogeneously is made powder.
Embodiment 2
Take by weighing raw material Radix Salviae Miltiorrhizae 35g, Radix Paeoniae Rubra 10g, Radix Platycodonis 10g, Flos Lonicerae 15g, Radix Scutellariae 10g, Fructus Forsythiae 10g and Radix Glycyrrhizae (processing) 6g; Pulverize and mix, the alcohol reflux with 80% makes ethanol extract, reclaims ethanol and obtains extractum, with adding an amount of dextrin in the extractum, makes soft material, granulates, and adds the magnesium stearate tabletting.
Embodiment 3
Take by weighing raw material Radix Salviae Miltiorrhizae 30g, Radix Paeoniae Rubra 15g, Radix Platycodonis 10g, Flos Lonicerae 15g, Radix Scutellariae 10g, Fructus Forsythiae 10g, Radix Ophiopogonis 10g and Radix Rehmanniae 10g and Radix Glycyrrhizae (processing) 6g;
Get above medical material, decoct with water 3 times, collecting decoction filters, and filtrate decompression concentrates, and puts coldly, and adding ethanol is 70% to containing the alcohol amount, leaves standstill, and filters, and filtrate decompression concentrates, reclaim ethanol after, be concentrated into relative density and be 1.25～1.35 extractum.Get extractum, spray drying gets extract powder.It is dry to granulate, promptly.
Claims (10)
1. Chinese medicine composition for the treatment of chronic pharyngitis is characterized in that it is made up of effective ingredient and/or pharmaceutically acceptable carrier, wherein prepares described raw materials of effective components weight portion and comprises:
Radix Salviae Miltiorrhizae 4-7, Radix Paeoniae Rubra 2-3, Flos Lonicerae 1-3, Fructus Forsythiae 1-3 and Radix Scutellariae 1-3.
2. according to the described Chinese medicine composition of claim 1, wherein prepare the raw materials of effective components weight portion and be: Radix Salviae Miltiorrhizae 5-6, Radix Paeoniae Rubra 2-3, Flos Lonicerae 2-3, Fructus Forsythiae 1-2 and Radix Scutellariae 1-2.
3. according to the described Chinese medicine composition of claim 2, wherein prepare the raw materials of effective components weight portion and be: Radix Salviae Miltiorrhizae 6, Radix Paeoniae Rubra 3, Flos Lonicerae 3, Fructus Forsythiae 2 and Radix Scutellariae 2.
4. according to claim 1,2 or 3 described Chinese medicine compositions, wherein can also add following parts by weight of Chinese traditional medicine material in the raw material: Radix Platycodonis 1-3 and Radix Glycyrrhizae 1-2.
5. according to the described Chinese medicine composition of claim 4, wherein the weight portion of raw material is Radix Platycodonis 1-2 and Radix Glycyrrhizae 1-1.5.
6. according to the described Chinese medicine composition of claim 5, wherein the weight portion of raw material is Radix Platycodonis 2 and Radix Glycyrrhizae 1.2.
7. according to claim 5 or 6 described Chinese medicine compositions, wherein can also add following parts by weight of Chinese traditional medicine material: Radix Ophiopogonis 1-3 and Radix Rehmanniae 1-3.
8. according to the described Chinese medicine composition of claim 7, wherein the weight portion of raw material is 1-2 and Radix Rehmanniae 1-2 Radix Ophiopogonis.
9. according to the described Chinese medicine composition of claim 8, wherein the consumption weight portion of raw material is Radix Ophiopogonis 2 and Radix Rehmanniae 2.
10. the preparation method of any one described Chinese medicine composition among the claim 1-9, it comprises the following steps:
Get above ten flavor medical materials, decoct with water 3 times, collecting decoction filters, and filtrate decompression concentrates, and puts coldly, and adding ethanol is 70% to containing the alcohol amount, leaves standstill, and filters, and filtrate decompression concentrates, reclaim ethanol after, be concentrated into relative density and be 1.25～1.35 extractum.Get extractum, spray drying gets extract powder.It is dry to granulate, promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB031600255A CN100490871C (en) | 2003-09-23 | 2003-09-23 | Combination of Chinese traditional medicine for curing chronic pharyngitis and preparation method |
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| CNB031600255A CN100490871C (en) | 2003-09-23 | 2003-09-23 | Combination of Chinese traditional medicine for curing chronic pharyngitis and preparation method |
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| CN1600356A true CN1600356A (en) | 2005-03-30 |
| CN100490871C CN100490871C (en) | 2009-05-27 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485827B (en) * | 2009-02-17 | 2011-03-23 | 张跃 | Medicament for treating chronic inflammation disease of throat |
| CN102406751A (en) * | 2011-11-17 | 2012-04-11 | 吴倩芸 | Traditional Chinese drug composition for treating absolute glaucoma |
| CN102772650A (en) * | 2012-07-12 | 2012-11-14 | 严中明 | Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method thereof |
| CN105031524A (en) * | 2015-07-13 | 2015-11-11 | 河南科技大学 | Traditional Chinese medicine combination used for treating chronic pharyngitis, traditional Chinese medicine oral preparation used for treating chronic pharyngitis and preparation method thereof |
| CN105106646A (en) * | 2015-09-12 | 2015-12-02 | 淄博齐鼎立专利信息咨询有限公司 | Medicinal preparation for treating chronic pharyngitis |
| CN105148037A (en) * | 2015-09-22 | 2015-12-16 | 陈华祥 | Traditional Chinese medicine used for treating sphagitis |
| CN105920392A (en) * | 2016-05-02 | 2016-09-07 | 赵迎春 | Traditional Chinese medicinal preparation for treating chronic pharyngitis and preparation method of traditional Chinese medicinal preparation |
| CN106924399A (en) * | 2017-03-27 | 2017-07-07 | 成都海青生物科技有限公司 | It is a kind of to treat endo-medicine of chronic simple pharyngitis and preparation method thereof |
| CN108434361A (en) * | 2018-06-26 | 2018-08-24 | 桐城市泰安中药材种植专业合作社 | A kind of Chinese medicine and preparation method thereof for treating chronic simple laryngitis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1278436A (en) * | 2000-06-07 | 2001-01-03 | 吴少伟 | Chinese medicine for acute and chronic laryngopharyngitis |
| CN1404853A (en) * | 2002-01-18 | 2003-03-26 | 陈炳南 | Medicine for treating tonsillitis and laryngopharyngitis |
-
2003
- 2003-09-23 CN CNB031600255A patent/CN100490871C/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485827B (en) * | 2009-02-17 | 2011-03-23 | 张跃 | Medicament for treating chronic inflammation disease of throat |
| CN102406751A (en) * | 2011-11-17 | 2012-04-11 | 吴倩芸 | Traditional Chinese drug composition for treating absolute glaucoma |
| CN102772650A (en) * | 2012-07-12 | 2012-11-14 | 严中明 | Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method thereof |
| CN102772650B (en) * | 2012-07-12 | 2014-05-07 | 蔡强 | Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method thereof |
| CN105031524A (en) * | 2015-07-13 | 2015-11-11 | 河南科技大学 | Traditional Chinese medicine combination used for treating chronic pharyngitis, traditional Chinese medicine oral preparation used for treating chronic pharyngitis and preparation method thereof |
| CN105106646A (en) * | 2015-09-12 | 2015-12-02 | 淄博齐鼎立专利信息咨询有限公司 | Medicinal preparation for treating chronic pharyngitis |
| CN105148037A (en) * | 2015-09-22 | 2015-12-16 | 陈华祥 | Traditional Chinese medicine used for treating sphagitis |
| CN105920392A (en) * | 2016-05-02 | 2016-09-07 | 赵迎春 | Traditional Chinese medicinal preparation for treating chronic pharyngitis and preparation method of traditional Chinese medicinal preparation |
| CN106924399A (en) * | 2017-03-27 | 2017-07-07 | 成都海青生物科技有限公司 | It is a kind of to treat endo-medicine of chronic simple pharyngitis and preparation method thereof |
| CN108434361A (en) * | 2018-06-26 | 2018-08-24 | 桐城市泰安中药材种植专业合作社 | A kind of Chinese medicine and preparation method thereof for treating chronic simple laryngitis |
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| Publication number | Publication date |
|---|---|
| CN100490871C (en) | 2009-05-27 |
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Granted publication date: 20090527 Termination date: 20200923 |