CN105031524A - Traditional Chinese medicine combination used for treating chronic pharyngitis, traditional Chinese medicine oral preparation used for treating chronic pharyngitis and preparation method thereof - Google Patents
Traditional Chinese medicine combination used for treating chronic pharyngitis, traditional Chinese medicine oral preparation used for treating chronic pharyngitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine combination used for treating chronic pharyngitis, a traditional Chinese medicine oral preparation used for treating chronic pharyngitis and a preparation method thereof. The traditional Chinese medicine combination is composed of, by weight, 10-20 parts of nutgrass galingale rhizome, 10-20 parts of albizzia bark, 6-12 parts of rehmannia root, 6-12 parts of red-rooted salvia root, 6-12 parts of ophiopogonis tuber, 6-12 parts of common peony root, 3-9 parts of platycodon root, 6-12 parts of burdock fruit and 6-9 parts of licorice. According to dialectic theories of conventional traditional Chinese medicine, the traditional Chinese medicine combination has effect of activating blood and qi circulation, can nourish yin and clear heat and detoxify and relieve sore throat, has remarkable treatment effect on improving symptoms of chronic pharyngitis and has remarkable treatment effect on chronic pharyngitis caused by qi and blood stasis and deficiency fire increase; the traditional Chinese medicine combination is a pure traditional Chinese medicine preparation, and is free of addition of any chemical drug, thereby being almost free of toxic and side effect after long-time administration; fundamental treatment of chronic pharyngitis is realized by combining recuperation and treatment.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine, be specifically related to a kind of Chinese medicine composition being used for the treatment of chronic pharyngitis, also relate to a kind of extract oral agent being used for the treatment of chronic pharyngitis and preparation method thereof simultaneously.
Background technology
Chronic pharyngitis is under pharyngeal mucosa, mucosa and adenoid diffuse inflammation, often shows as a part for upper respiratory tract chronic inflammatory disease, and the general course of disease is longer, and symptom is obstinate, not easily cures.According to statistics, chronic pharyngitis sickness rate accounts for 10% ~ 20% of Throat diseases, is multiplely born in adult, and city sickness rate is high.This disease is medically called sore throat in China, is to cause through BI-syndrome involved the blood vessels resistance obstructed because interior exopathogen poison gathers, and shows as red swelling and pain of throat, dysphagia or difficulty, the pharyngeal laryngopharyngeal diseases symptom such as blocking.This disease is recorded in Huangdi's Internal Classics the earliest: " monoyin and monoyang knot and be sore throat ", how caused by asthenic fire.
Chronic pharyngitis main manifestations is pharyngeally have various discomfort sensation, as foreign body sensation, itch, scorching hot, dry, hypodynia, dry cough, abundant expectoration not mucofilin, speech fatiguability, or gargle in brushing teeth, easily feel sick when talking many disgusting.From pathology, chronic pharyngitis is the pharyngeal pathological changes of diffusivity caused by chronic infection, and mainly pharyngeal mucosal inflammation, is mainly in adult.From the cause of disease, chronic pharyngitis mainly patient stimulate by dust or harmful gas for a long time, tobacco and wine excessively or other bad life habits etc. cause, also can be the topical manifestations of some systemic disease, as anemia, diabetes, liver cirrhosis and chronic nephritis etc.
Doctor trained in Western medicine thinks that the generation of chronic pharyngitis is relevant with many factors, and the recurrent exerbation of acute pharyngitis is the main cause causing chronic pharyngitis; The upper respiratory tract pathological changes of pharyngeal vicinity, weather and territorial environment change, occupational factor, systemic factor and intolerance factors all can induce the generation of primary disease.Report and detect virus infectious patient is pharyngeal, and think that the morbidity of chronic pharyngitis is relevant with viral infection, caused by the infection of mainly Epstein-Barr virus and adenovirus.The traditional Chinese medical science thinks that depletion fire syndrome going up that the cause of disease of chronic pharyngitis causes based on YIN-deficiency of the lung and kidney, throat lose and support.Describe hyperactivity of deficient fire in Yuan Dynasty's " danxi's experiential therapy " and can sore throat be caused, and treat it by the method for yin nourishing pathogenic fire reducing.Then, the famous judgement that " Elementary Medicine " proposes " throat disease all belong to fire ", and pointing out " fire point deficiency and excess ", and spleen, liver, kidney three deficiency of five ZANG-organs fire can cause throat disease." otorhinolaryngology of Chinese medicine " proposes because of the empty and stasis of blood, because of chronic pharyngitis caused by the stagnant and stasis of blood pathology.QI and blood phlegm-turbidity and blood stasis resistance namely can be all cards of throat because of, can be again all card pathological changes of throat fruit.The turbid heap soil or fertilizer over and around the roots of expectorant is stagnant, and stasis blocking air flue, does not with the passing of time change, QI and blood pent-up, strongly fragrant and heat-transformation, forms chronic sore throat.Doctor trained in Western medicine adopts antibiotics to treat chronic pharyngitis mostly, or is aided with dexamethasone and Dobell's solution, nitrofural collutory etc., but is difficult to radical cure, easily recurs.Chinese traditional treatment chronic pharyngitis is because cost is low, be subject to people's attention without obvious toxic-side effects.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition being used for the treatment of chronic pharyngitis, cost is low, without obvious toxic-side effects, evident in efficacy to chronic pharyngitis.
Second object of the present invention is to provide a kind of extract oral agent being used for the treatment of chronic pharyngitis.
3rd object of the present invention is to provide a kind of preparation method being used for the treatment of the extract oral agent of chronic pharyngitis.
In order to realize above object, the technical solution adopted in the present invention is:
A kind of Chinese medicine composition being used for the treatment of chronic pharyngitis, comprise the component of following parts by weight: Rhizoma Cyperi 10 ~ 20 parts, Cortex Albiziae 10 ~ 20 parts, Radix Rehmanniae 6 ~ 12 parts, Radix Curcumae 6 ~ 12 parts, Radix Salviae Miltiorrhizae 6 ~ 12 parts, Radix Ophiopogonis 6 ~ 12 parts, Radix Paeoniae Rubra 6 ~ 12 parts, Radix Platycodonis 3 ~ 9 parts, Fructus Arctii 6 ~ 12 parts, 3 ~ 9 parts, Radix Glycyrrhizae.
Preferably, the described Chinese medicine composition being used for the treatment of chronic pharyngitis comprises the component of following parts by weight: Rhizoma Cyperi 15 parts, Cortex Albiziae 15 parts, Radix Rehmanniae 9 parts, Radix Curcumae 9 parts, Radix Salviae Miltiorrhizae 9 parts, Radix Ophiopogonis 9 parts, Radix Paeoniae Rubra 9 parts, Radix Platycodonis 6 parts, Fructus Arctii 9 parts, 6 parts, Radix Glycyrrhizae.
Of the present inventionly be used for the treatment of in the Chinese medicine composition of chronic pharyngitis, the property of medicine drug effect of each component is as follows:
Rhizoma Cyperi: mildly bitter flavor, micro-sweet, property is pungent, returns liver, spleen, tri-jiao channel, has dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, effect of menstruction regulating and pain relieving; Be used for the treatment of stagnation of QI due to depression of the liver, sternal rib pain, stagnation of QI in spleen and stomach, hernia pain, menoxenia etc.Rhizoma Cyperi has the effect strengthening blood circulation promoting and blood stasis dispelling, can strengthen its prolongation clotting time of mice, suppress thrombotic effect in Mice Body, strengthen it and suppress the effect of rats in vitro thrombosis after adding Rhizoma Cyperi in BUYANG HUANWU TANG.Modern pharmacological research confirms, Rhizoma Cyperi is mainly containing volatile oil composition, and other chemical compositions also have flavonoid, saccharide, triterpenes etc.Rhizoma Cyperi has the effects such as antiinflammatory, blood sugar lowering, antiplatelet, neuroprotective system, antianaphylaxis; Rhizoma Cyperi ethanol extraction has obvious inhibitory action to the platelet aggregation that collagen, thrombin etc. cause; Rhizoma Cyperi total flavones and ethyl acetate extract have obvious inhibitory action to Salmonella enteritidis, staphylococcus aureus and enterococcus faecalis; Caused guinea pig bronchial convulsion is twin protective effect to histamine's spraying for cyperol extract, and the prostaglandin biosynthesis inhibiting substances contained by Rhizoma Cyperi is mainly α-cyperone.
Cortex Albiziae: sweet in the mouth, property is put down, GUIXIN, Liver Channel.There is resolving stagnation for tranquilization, effect of promoting blood circulation and detumescence; Cure mainly melancholy insomnia, irritability, inside and outside carbuncle and ulcer, injury from falling down." animals and plants Folk medicine " is recorded: control cough.Containing number of chemical compositions such as triterpene, flavone, lignanoid, alkaloid, tannin and polysaccharide in Cortex Albiziae.Modern pharmacological research shows, Cortex Albiziae has the effects such as tranquilizing soporific, anxiety, antidepressant, antitumor, immunostimulant, antifertility; Cortex Albiziae has anti-allergic effects, and its decoct rat oral gavage administration can suppress its peritoneal mast cells retting conditions, can obviously suppress antigen (horse serum) to the sensitization process of rat and antibody generation process in addition.
Radix Rehmanniae: sweet-bitter flavor, cold in nature, GUIXIN, liver, kidney channel.Clearing away heat and promoting production of body fluid, cooling blood for hemostasis.Radix Rehmanniae is tonification class Chinese medicine, and for calentura, crimson tongue excessive thirst, the deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle, dermexanthesis.Radix Rehmanniae is containing, for example saccharide compounds such as iridoid glycoside compounds and Dihuang polysaccharide such as catalpol.Research proves, catalpol has the 1. effect such as anticancer, neuroprotective, antiinflammatory, blood sugar lowering; 2. to H
2o
2the star spongiocyte oxidative damage of induction has protective effect; 3. diabetic mice is caused to alloxan and have obvious hypoglycemic activity.Dihuang polysaccharide resembles for different model of blood dificiency mouse peripheral blood, bone marrow nucleated cell declines all has antagonism, has promote propagation, differentiation to mouse hematopoietic stem cell.Dihuang polysaccharide is the effective ingredient having immunity and Tumor suppression activity in Radix Rehmanniae concurrently.Experiment proves that Radix Rehmanniae can significantly improve the lymphocytic breeder reaction ability of normal mouse T and the long period can maintain higher level, show obvious immunoregulatory activity, this and the YIN nourishing of enriching blood of Radix Rehmanniae, beneficial essence are filled out the traditional functions such as marrow and are matched, show application prospect widely, in enhancing immunity, anti-malignant tumor, slow down aging etc., play certain effect.
Radix Curcumae: acrid in the mouth is bitter, and cold in nature, GUIXIN, liver, gallbladder meridian, have effect of blood-activating and qi-promoting pain relieving, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, cooling blood for hemostasis, is usually used in the diseases such as amenorrhea dysmenorrhea, chest and abdomen swelling and pain, jaundice dark coloured urine.The tuber of Radix Curcumae mainly containing compositions such as volatile oil, starch and curcumins, wherein volatile oil mainly contain curcumene, sesquiterpene alcohols, Camphora, camphene etc.Research shows, Radix Curcumae volatile oil has adjustment to exempt from remorse function; By strengthening the Detoxication of liver, and can resist or alleviate poisonous substance to a certain extent hepatoprotective effect is played to the destruction of liver; By improving erythrocytic function, extending its life-span, safeguarding normal blood viscosity and playing and improving hemorheological property effect; And the effect such as free radical resisting damage, analgesia.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, GUIXIN, Liver Channel.Promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Traditional medicine is thought, blood system walked by Radix Salviae Miltiorrhizae, promoting blood circulation, and merit arrogates to oneself blood circulation promoting and blood stasis dispelling.Effect of Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the relieving restlessness that clears away heart-fire with resist myocardial ischemia, anti-cerebral ischemia, antithrombotic, improve microcirculation, promote the reparation organized and regeneration, and the multiple pharmacological effect such as sedation and analgesia is relevant.Modern pharmacology research shows, the chemical composition of Radix Salviae Miltiorrhizae mainly contains two large classes: fat-soluble tanshinone compound and water miscible phenolic acid compound.TANSHINONES has the effect of anti-inflammation, has inhibitory action to most antibacterial, as escherichia coli, staphylococcus aureus, Staphylococcus albus etc.Radix Salviae Miltiorrhizae can prevent the diffusion of inflammation, reduces leukocytic quantity, reduces the content of the PGF2 in blood, thus reaches the therapeutical effect to inflammation.Radix Salviae Miltiorrhizae Injection obviously can suppress lung fibrosis, reduces the inflammatory cell infiltration of lung tissue, also can protect PCEC and TypeⅡ pneumocyte, increases pulmonary capillary blood flow.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, have YIN nourishing benefit essence, Replenishing QI and nourishing YIN, clear away heart-fire the effect such as relieving restlessness, loosening bowel to relieve constipation, cures mainly dryness of the lung dry cough, cough due to consumptive disease, thirsty, the vexed insomnia of Tianjin wound, interior-heat are quenched one's thirst, dryness of the intestine constipation.Modern study shows, has been rich in the effective ingredient such as polysaccharide, saponin, flavone in Tubers of Ophiopogon japonicus, has heart tonifying, diuresis, the pharmacological action such as antibacterial, in addition, in treatment angina pectoris, arrhythmia, diabetes, chronic cough are not healed etc., has good effect.Research display, Radix Ophiopogonis polysaccharide can promote humoral immunization and cellular immune function, has good immunostimulant and stimulation.
Radix Paeoniae Rubra: bitter in the mouth, cold nature, returns Liver Channel.The pain relieving of function clots absorbing, removing heat from blood detumescence; Cure mainly the stagnant amenorrhea of the stasis of blood, hernia abdominal mass gathered, hypochondriac pain of suffering from abdominal pain, epistaxis dysentery, discharging fresh blood stool, conjunctival congestion carbuncle.The monoterpene and methods of glycosides etc. thereof of Radix Paeoniae Rubra active ingredient mainly based on peoniflorin, have the effects such as antiinflammatory, anti-allergy action, scavenging capacity oxygen-derived free radicals.Pharmaceutical research shows Radix Paeoniae Rubra anticoagulant, improves erythrocytic permeability, increases erythrocyte to the resistance of hypotonic tension force, has the effect of necessarily stablizing erythrocyte membrane structure.
Radix Platycodonis: bitter in the mouth, property is put down, and returns lung meridian.There is out lung qi dispersing gas, the effect of evacuation of pus of eliminating the phlegm.The diseases such as be used for the treatment of exogenous cough, laryngopharynx swelling and pain, lung abscess is spat, fullness in the chest and hypochondriac pain, dysentery stomachache." pearl sac " is recorded: " passing through with Radix Glycyrrhizae, is drugs of guiding other drugs to act on upper JIAO ".Radix Platycodonis has many-sided pharmacological action, is wherein a most important ring to the regulating and controlling effect of macrophage, is one of the mechanism of action of Radix Platycodonis antiinflammatory, antitumor, resisting pathogenic microbes.
Fructus Arctii: acrid in the mouth, hardship, cold in nature, attach to the lung and stomach meridians.There is dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, effect of removing toxic substances and promoting subsidence of swelling.Fructus Arctii " the logical twelve regular channels, except the five internal organs bad odor " is recorded in Compendium of Material Medica.Fructus Arctii belongs to wind-heat-dispersing medicinal in diaphoretic medicine, can be used for anemopyretic cold, cough with copious phlegm, laryngopharynx swelling and pain etc.Modern pharmacological research shows; containing multiple compounds in Fructus Arctii, stem and leaf and root; mainly comprise polysaccharide, lignanoids, phenolic hydroxyl group material, volatile oil, fatty acid and the composition such as a small amount of alkaloid, sterol, vitamin and aldehydes, polyacetylene class material, the multiple pharmacological effect such as the antitumor had, immunomodulating and antiinflammatory, anti-bacteria and anti-virus, anti-diabetic, antioxidation, Liver protection are owing to the existence of these compositions.Obtain a kind of low-molecular-weight fructofuranosan from Fructus Arctii root, in the antitussive experiment of cat, show the identical antitussive activity of the non-narcotic synthesising preparation that is used for the treatment of cough with some clinically; In mitogenesis experiment, the biologically of this levan is suitable with the zymosan immunomodulator of business.
Radix Glycyrrhizae: sweet in the mouth, property is put down, and returns spleen, stomach, lung meridian.Primary efficacy is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, clear throat, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Modern pharmacological research proves, Radix Glycyrrhizae agent has antiinflammatory and antianaphylactic function, and can protect throat and the tunica mucosa tracheae of inflammation, relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis, therefore in doctor trained in Western medicine clinically mainly as demulcent.Licoflavone, Radix Glycyrrhizae extractum and enoxolone all have obvious antitussive effect; Phlegm-dispelling functions is also comparatively remarkable, and its action intensity is glycyrrhizic acid > licoflavone > Radix Glycyrrhizae extractum.Radix Glycyrrhizae extractum and glycyrrhizic acid have the Detoxication of similar glucuronic acid to some poisonous substance.
Medication meridian attribution analysis shows, and the present invention's control is QI and blood stasis, the card of depletion fire syndrome going up; Feelings will is unsuccessful, and temper is not relaxed, the qi-blood disharmony tears throat that can not allow, elementization deficiency of lung-YIN, and hyperactivity of deficient fire, causes throat discomfort, or foreign body sensation, puzzled dry itching throat, or scorching hot hypodynia, or dry cough is felt sick.Reusing Rhizoma Cyperi in side, Cortex Albiziae promoting blood circulation and detumescence, is monarch drug.Radix Curcumae blood-activating and qi-promoting, principal drug assistance resolving depression eliminating stagnation, glutinous rehmannia for cooling blood, heat clearing away with separate asthenic fire its for ministerial drug.Cloudy Tianjin of nourishing the lung and kidney Radix Ophiopogonis, make moist throat; Radix Platycodonis, Fructus Arctii lung qi dispersing eliminate the phlegm, liyan jiedu its be adjuvant drug.Radix Glycyrrhizae helps Radix Platycodonis patent throat, again can coordinating the actions of various ingredients in a prescription, for making medicine.All medicines share to be played resolving depression altogether and invigorates blood circulation, relieving sore-throat by clearing away heat, the merit of nourishing YIN to relieve dryness.
The Chinese medicine composition being used for the treatment of chronic pharyngitis of the present invention, is undertaken composite by Rhizoma Cyperi, Cortex Albiziae, Radix Rehmanniae, Radix Curcumae, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, Radix Paeoniae Rubra, Radix Platycodonis, Fructus Arctii, Radix Glycyrrhizae etc., and formula is reasonable, determined curative effect; Traditionally differential diagnosis in tcm is theoretical, except the effects such as blood-activating and qi-promoting, also focuses on nourishing YIN and clearing away heat, resolving toxin and disinhibiting the throat, and improving in chronic pharyngitis symptom evident in efficacy, to QI and blood stasis, the chronic pharyngitis caused by depletion fire syndrome going up has significant therapeutic effect; Be pure Chinese medicinal preparation, do not add any chemicals, long-term taking is several to have no side effect; Patient is implemented to tune, controls combination, thus achieves the basic treatment to chronic pharyngitis.
The Chinese medicine composition being used for the treatment of chronic pharyngitis of the present invention, the dosage form that can be made into field of Chinese medicines routine is taken, dosage form as medically acceptable in decoction etc.Such as, each component will be measured by formula, and make decoction after decocting with water and directly take.
A kind of extract oral agent being used for the treatment of chronic pharyngitis, raw material primarily of following parts by weight is made: Rhizoma Cyperi 10 ~ 20 parts, Cortex Albiziae 10 ~ 20 parts, Radix Rehmanniae 6 ~ 12 parts, Radix Curcumae 6 ~ 12 parts, Radix Salviae Miltiorrhizae 6 ~ 12 parts, Radix Ophiopogonis 6 ~ 12 parts, Radix Paeoniae Rubra 6 ~ 12 parts, Radix Platycodonis 3 ~ 9 parts, Fructus Arctii 6 ~ 12 parts, 3 ~ 9 parts, Radix Glycyrrhizae.
Preferably, the described extract oral agent being used for the treatment of chronic pharyngitis is made primarily of the raw material of following parts by weight: Rhizoma Cyperi 15 parts, Cortex Albiziae 15 parts, Radix Rehmanniae 9 parts, Radix Curcumae 9 parts, Radix Salviae Miltiorrhizae 9 parts, Radix Ophiopogonis 9 parts, Radix Paeoniae Rubra 9 parts, Radix Platycodonis 6 parts, Fructus Arctii 9 parts, 6 parts, Radix Glycyrrhizae.
The above-mentioned preparation method being used for the treatment of the extract oral agent of chronic pharyngitis, comprises the following steps:
1) measure raw material of Chinese medicine by formula, decoct with water for twice, merge decoction liquor;
2) by step 1) gained decoction liquor is filtered successively, is concentrated, carry out secondary filter again after cold preservation, to obtain final product.
Step 1) in, describedly decoct with water for twice in process, add water dipped medical material surface 5 ~ 15cm at every turn; Decoct after soaking 20 ~ 40min after first time adds water; Each decocting time is 0.5 ~ 1.5h.
Step 2) in, described filtration is that employing 5 layers of gauze filter.
Step 2) in, described concentrating refers to that being concentrated into relative density is 1.07 ~ 1.20.
Step 2) in, the temperature of described cold preservation is 4 DEG C, and cold preservation time is 12 ~ 36h.
Step 2) in, also carry out thin up after secondary filter; Described thin up refers to that adding purified water dilutes; The amount adding purified water is: every 0.5 ~ 1.5g raw material of Chinese medicine correspondence adds water 1ml.
Step 2) in, also carry out sterilization treatment after described thin up; Described sterilization treatment is the steam sterilization 30min of employing 100 DEG C.
The extract oral agent being used for the treatment of chronic pharyngitis of the present invention, be adopt above-mentioned Chinese medicine composition to decoct with water the Chinese medicine preparation extracting and make, improve the stability of medicine and the compliance of patient, clinical practice is evident in efficacy; Can large-scale production be carried out, be convenient for carrying and take; For QI and blood stasis in chronic pharyngitis, the theory of Chinese medical science of depletion fire syndrome going up etc., the present invention carries out the new Chinese medicinal composition preparation of reasonable compatibility, take promoting blood circulation by removing blood stasis as elder generation, nourishing YIN and clearing away heat Zhi Qiben in addition again, resolving toxin and disinhibiting the throat controls its mark, can give full play to the comprehensively regulating effect of compound Chinese medicinal preparation, reach the curative effect to chronic pharyngitis treating both the principal and secondary aspects of a disease.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further illustrated.
Embodiment 1
The Chinese medicine composition being used for the treatment of chronic pharyngitis of the present embodiment, is made up of the component of following parts by weight: Rhizoma Cyperi 15 parts, Cortex Albiziae 15 parts, Radix Rehmanniae 9 parts, Radix Curcumae 9 parts, Radix Salviae Miltiorrhizae 9 parts, Radix Ophiopogonis 9 parts, Radix Paeoniae Rubra 9 parts, Radix Platycodonis 6 parts, Fructus Arctii 9 parts, 6 parts, Radix Glycyrrhizae.
The extract oral agent being used for the treatment of chronic pharyngitis of the present embodiment, the raw material primarily of following parts by weight is made: Rhizoma Cyperi 15 parts, Cortex Albiziae 15 parts, Radix Rehmanniae 9 parts, Radix Curcumae 9 parts, Radix Salviae Miltiorrhizae 9 parts, Radix Ophiopogonis 9 parts, Radix Paeoniae Rubra 9 parts, Radix Platycodonis 6 parts, Fructus Arctii 9 parts, 6 parts, Radix Glycyrrhizae.
The preparation method being used for the treatment of the extract oral agent of chronic pharyngitis of the present embodiment, comprises the following steps:
1) measure raw material of Chinese medicine by formula, add water dipped medical material surface 10cm at every turn, decocts again, successively decoct 2 times, each 1h, merge decoction liquor after soaking 30min for the first time;
2) step 1 is got) gained decoction liquor, with 5 layers of filtered through gauze, getting filtrate, to be concentrated into relative density be after 1.17, after 4 DEG C of cold preservation 24h, carry out secondary filter (with 5 layers of filtered through gauze) again, get filtrate and add purified water and dilute, the amount adding purified water is that every 0.96g raw material of Chinese medicine correspondence adds water 1ml, mixing, subpackage, 100 DEG C of flowing steam sterilization 30min, to obtain final product.
The present embodiment gained extract oral agent specification is 250ml/ bottle.Usage and dosage: oral, 3 times on the one, a 20 ~ 30ml.Take in process and should be careful in one's diet, avoid cold and uncooked food, greasy, pungent.
Embodiment 2
The Chinese medicine composition being used for the treatment of chronic pharyngitis of the present embodiment, is made up of the component of following parts by weight: Rhizoma Cyperi 10 parts, Cortex Albiziae 10 parts, Radix Rehmanniae 6 parts, Radix Curcumae 6 parts, Radix Salviae Miltiorrhizae 6 parts, Radix Ophiopogonis 6 parts, Radix Paeoniae Rubra 6 parts, Radix Platycodonis 3 parts, Fructus Arctii 6 parts, 3 parts, Radix Glycyrrhizae.
The extract oral agent being used for the treatment of chronic pharyngitis of the present embodiment, the raw material primarily of following parts by weight is made: Rhizoma Cyperi 10 parts, Cortex Albiziae 10 parts, Radix Rehmanniae 6 parts, Radix Curcumae 6 parts, Radix Salviae Miltiorrhizae 6 parts, Radix Ophiopogonis 6 parts, Radix Paeoniae Rubra 6 parts, Radix Platycodonis 3 parts, Fructus Arctii 6 parts, 3 parts, Radix Glycyrrhizae.
The preparation method being used for the treatment of the extract oral agent of chronic pharyngitis of the present embodiment, comprises the following steps:
1) measure raw material of Chinese medicine by formula, add water dipped medical material surface 5cm at every turn, decocts again, successively decoct 2 times, each 0.5h, merge decoction liquor after soaking 20min for the first time;
2) step 1 is got) gained decoction liquor, with 5 layers of filtered through gauze, getting filtrate, to be concentrated into relative density be after 1.07, after 4 DEG C of cold preservation 12h, carry out secondary filter (with 5 layers of filtered through gauze) again, get filtrate and add purified water and dilute, the amount adding purified water is that every 0.5g raw material of Chinese medicine correspondence adds water 1ml, mixing, subpackage, 100 DEG C of flowing steam sterilization 30min, to obtain final product.
The present embodiment gained extract oral agent specification is 250ml/ bottle.Usage and dosage: oral, 3 times on the one, a 20 ~ 30ml.Take in process and should be careful in one's diet, avoid cold and uncooked food, greasy, pungent.
Embodiment 3
The Chinese medicine composition being used for the treatment of chronic pharyngitis of the present embodiment, is made up of the component of following parts by weight: Rhizoma Cyperi 20 parts, Cortex Albiziae 20 parts, Radix Rehmanniae 12 parts, Radix Curcumae 12 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Ophiopogonis 12 parts, Radix Paeoniae Rubra 12 parts, Radix Platycodonis 9 parts, Fructus Arctii 12 parts, 9 parts, Radix Glycyrrhizae.
The extract oral agent being used for the treatment of chronic pharyngitis of the present embodiment, the raw material primarily of following parts by weight is made: Rhizoma Cyperi 20 parts, Cortex Albiziae 20 parts, Radix Rehmanniae 12 parts, Radix Curcumae 12 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Ophiopogonis 12 parts, Radix Paeoniae Rubra 12 parts, Radix Platycodonis 9 parts, Fructus Arctii 12 parts, 9 parts, Radix Glycyrrhizae.
The preparation method being used for the treatment of the extract oral agent of chronic pharyngitis of the present embodiment, comprises the following steps:
1) measure raw material of Chinese medicine by formula, add water dipped medical material surface 15cm at every turn, decocts again, successively decoct 2 times, each 1.5h, merge decoction liquor after soaking 40min for the first time;
2) step 1 is got) gained decoction liquor, with 5 layers of filtered through gauze, getting filtrate, to be concentrated into relative density be after 1.20, after 4 DEG C of cold preservation 36h, carry out secondary filter (with 5 layers of filtered through gauze) again, get filtrate and add purified water and dilute, the amount adding purified water is that every 1.5g raw material of Chinese medicine correspondence adds water 1ml, mixing, subpackage, 100 DEG C of flowing steam sterilization 30min, to obtain final product.
The present embodiment gained extract oral agent specification is 250ml/ bottle.Usage and dosage: oral, 3 times on the one, a 20 ~ 30ml.Take in process and should be careful in one's diet, avoid cold and uncooked food, greasy, pungent.
Experimental example
This experimental example carries out clinical observation on the therapeutic effect to the Chinese medicine composition that embodiment 1 gained is used for the treatment of chronic pharyngitis.
For verifying the therapeutic effect being used for the treatment of the Chinese medicine composition of chronic pharyngitis of embodiment 1, carried out efficiency assay in The First Affiliated Hospital of Henan University of Science and Technology, clinical test results is as follows:
1. physical data
(1) Disease Diagnosis Standard:
Formulate with reference to " disease of tcm Standardization of diagnosis and curative effect ": 1. with pharyngeal drying or itch, pain, foreign body sensation, swelling sense is for primary symptom; 2. the course of disease is long, heavy time light during pharyngeal malaise symptoms; 3. often there is acute sore throat history of repeated attack, or a long-term mouth breathing because of nasal obstruction, or cause morbidity because of tobacco and wine are excessive, surrounding air is dry, dust abnormal flavour stimulation etc.; 4. pharyngeal inspection mucosa swelling, or have atrophy, or have kermesinus speckle shape, dendroid congested, pharynx side enlargement, retropharyneal folliculosis.
Observation index: indices in on-test and at the end of each test l time, and inquire the medical history of patient in detail, main pharyngeal symptom etc.; Check the signs such as the pharyngeal mucosa edema of patient, hyperemia, retropharyneal folliculosis, secretions; Each index and sign change before and after treatment is recorded respectively by check result.
(2) inclusive criteria: possess an above-mentioned symptom or partial symptoms, namely meets chronic pharyngitis diagnosis.
(3) exclusion standard: 1. chronic pharyngitis is with chronic throat diseases person (as chronic laryngitis etc.); 2. chronic pharyngitis is with lower respiratory tract chronic inflammatory disease person; 3. person caused by some invisible pathological changes of oropharynx, nasopharynx, nose, larynx, esophagus and whole body is confirmed on inspection; 4. other pattern of syndrome person outside the dialectical genus deficiency of yin and stagnation of blood of chronic pharyngitis; 5. the age below 18 one full year of life or more than 65 one full year of life and trimester of pregnancy or women breast-feeding their children, allergic constitution person; 6. the severe primary diseases such as cardiovascular, liver, kidney or hemopoietic system are associated with, psychiatric patient.
2. divide into groups
113 routine patients are Affiliated Hospital of University Of Science and Technology Of He'nan out-patient.Simple randomization method is adopted all cases to be divided at random treatment group and matched group 2 groups.In treatment group 56 example, man 24 example, female 32 example, average 0.5 ~ 5 year of the course of disease; In matched group 57 example, man 22 example, female 35 example, average 0.3 ~ 5 year of the course of disease.The physical data such as 2 groups of sexes, age, courses of disease compare, the equal not statistically significant of difference (P>0.01).
3. research method
Treatment group takes the extract oral agent that the embodiment of the present invention 1 provides, oral, a 20 ~ 30ml, 3 times on the one.Matched group normal saline 20ml, gentamycin 80,000 U, dexamethasone 5mg Neulized inhalation.
Each group of case is stopped using other Therapeutic Method at least 3 week before the treatment, then daily Chinese medicine composition of the present invention, a 20 ~ 30ml, 3 times on the one.Within 10 days, be 1 course for the treatment of, observe the curative effect after 3 courses for the treatment of.Treatments period can not use other any medicine.Take in process and should be careful in one's diet, avoid cold and uncooked food, greasy, pungent.
4. curative effect determinate standard
Draft by " Chinese medical disease Standardization of diagnosis and curative effect ": cure: pharyngalgia, dryly to itch, the subjective symptoms such as foreign body sensation all disappears, check and find that pharyngeal mucosa congestion and edema obviously disappears, pharynx rear wall enlargement lymph follicle recovers normal, and mucosal secretions disappears substantially; Take a turn for the better: large portion subjective symptoms disappears, and only has pharyngeal slight foreign body sensation, check and find that pharyngeal mucosa hyperemia obviously alleviates, pharynx rear wall has minority enlargement lymph follicle, has a small amount of mucus; Invalid: all diseases and check result and more unchanged before treating.
5. result of study
After treating 3 courses for the treatment of, treatment group cures 22 examples, and take a turn for the better 19 examples, and do not heal 7 examples, and total effective rate is 85.4%; Matched group cures 12 examples, and take a turn for the better 12 examples, and do not heal 16 examples, and total effective rate is 60.0%.Experimental result is as shown in table 1, and treatment group is evident in efficacy is better than matched group, and 2 groups are compared, and difference has statistical significance (P<0.01).
Table 1 treatment group and matched group Clinical efficacy comparison
| Group | Add up to | Cure | Take a turn for the better | Do not heal | Total effective rate (%) |
| Treatment group | 56 | 27 | 22 | 8 | 87.5* |
| Matched group | 57 | 17 | 17 | 23 | 59.6 |
Compare with matched group, * P<0.01
6. conclusion
The oral agents that Chinese medicine composition of the present invention is made has nourishing YIN and clearing away heat, promote the production of body fluid moisturize, effect of sore-throat relieving eliminating stagnation, detumescence, Comprehensive Treatment can be carried out for the chronic pharyngitis of deficiency of yin and stagnation of blood, evident in efficacy; There is not the untoward reaction such as hepatic and renal function injure during taking, show that Chinese medicine composition of the present invention has good safety.
Model case
Model case 1: Zhang, man, 53 years old.Main suit pharyngeal uncomfortable 2 years repeatedly, recently because of upper respiratory tract infection recurrence, has thing to block in self-induction pharynx, pharyngeal scorching hot, dry cough without phlegm, night xerostomia pharyngalgia, body of the tongue is light red, tongue fur BOHUANG, thready pulse slightly number.Toposcopy is shown in: pharyngeal congestion, pharynx rear wall many pieces of lymph foilicie hyperplasias, and tonsil is little, and two pulmonary respiration sound is clear, auscultation no abnormality seen.Examine as " chronic pharyngitis ".Take extract oral agent 2 course of therapy that the embodiment of the present invention 1 provides.Symptom alleviates, pharyngeal congestion disappear, 5 the course for the treatment of posterior phraynx rear wall lymph follicle substantially disappear.Continue and take after treatment, and advise patient to note pre-preventing diseases caused by external factors, excessively do not use throat, after following up a case by regular visits to 2 years, have no recurrence.
Model case 2: Liu, female, 41 years old, teacher, time medical, pharyngeal dry pain was uncomfortable, itching throat hoarseness, and readme suffers from chronic pharyngitis for many years, in the too much postemphasis of speech.Once Multiple Classes of Antibiotics and various buccal tablet was taken, but poor effect.Readme itching throat, foreign body sensation, dry cough, secretions increase.Check: pharyngeal chronic congestion, lymph foilicie hyperplasia, lateral pharyngeal band hypertrophy is plump.Examine as " chronic pharyngitis ".Give the extract oral agent that the embodiment of the present invention 2 provides, advise it to take on request.After treating 3 courses for the treatment of, the readme state of an illness is clearly better, and after 3 courses for the treatment of of following the service, symptom disappears completely, follows up a case by regular visits to and does not recur half a year.
Model case 3: thank certain, man, 35 years old.Main suit's uncomfortable in chest suppressing out of breath is risen, and breathes effort, dry laryngopharynx pain, and cough, expectorant matter thickness is not easily coughed, and has foreign body sensation in pharynx, the course of disease 2 years.Toposcopy: mucosa fills the air hyperemia, vasodilation, color are dark red, with sticky secretions.Examine as " chronic pharyngitis ".Give the extract oral agent that the embodiment of the present invention 3 provides, advise it to take on request.After treating 1 course for the treatment of, readme symptom alleviates, and after 3 courses for the treatment of of following the service, symptom disappears completely, follows up a case by regular visits to and does not recur half a year.
Claims (10)
1. one kind is used for the treatment of the Chinese medicine composition of chronic pharyngitis, it is characterized in that: the component comprising following parts by weight: Rhizoma Cyperi 10 ~ 20 parts, Cortex Albiziae 10 ~ 20 parts, Radix Rehmanniae 6 ~ 12 parts, Radix Curcumae 6 ~ 12 parts, Radix Salviae Miltiorrhizae 6 ~ 12 parts, Radix Ophiopogonis 6 ~ 12 parts, Radix Paeoniae Rubra 6 ~ 12 parts, Radix Platycodonis 3 ~ 9 parts, Fructus Arctii 6 ~ 12 parts, 3 ~ 9 parts, Radix Glycyrrhizae.
2. the Chinese medicine composition being used for the treatment of chronic pharyngitis according to claim 1, is characterized in that: the component comprising following parts by weight: Rhizoma Cyperi 15 parts, Cortex Albiziae 15 parts, Radix Rehmanniae 9 parts, Radix Curcumae 9 parts, Radix Salviae Miltiorrhizae 9 parts, Radix Ophiopogonis 9 parts, Radix Paeoniae Rubra 9 parts, Radix Platycodonis 6 parts, Fructus Arctii 9 parts, 6 parts, Radix Glycyrrhizae.
3. one kind is used for the treatment of the extract oral agent of chronic pharyngitis, it is characterized in that: the raw material primarily of following parts by weight is made: Rhizoma Cyperi 10 ~ 20 parts, Cortex Albiziae 10 ~ 20 parts, Radix Rehmanniae 6 ~ 12 parts, Radix Curcumae 6 ~ 12 parts, Radix Salviae Miltiorrhizae 6 ~ 12 parts, Radix Ophiopogonis 6 ~ 12 parts, Radix Paeoniae Rubra 6 ~ 12 parts, Radix Platycodonis 3 ~ 9 parts, Fructus Arctii 6 ~ 12 parts, 3 ~ 9 parts, Radix Glycyrrhizae.
4. the extract oral agent being used for the treatment of chronic pharyngitis according to claim 3, is characterized in that: the raw material primarily of following parts by weight is made: Rhizoma Cyperi 15 parts, Cortex Albiziae 15 parts, Radix Rehmanniae 9 parts, Radix Curcumae 9 parts, Radix Salviae Miltiorrhizae 9 parts, Radix Ophiopogonis 9 parts, Radix Paeoniae Rubra 9 parts, Radix Platycodonis 6 parts, Fructus Arctii 9 parts, 6 parts, Radix Glycyrrhizae.
5. be used for the treatment of a preparation method for the extract oral agent of chronic pharyngitis as claimed in claim 3, it is characterized in that: comprise the following steps:
1) measure raw material of Chinese medicine by formula, decoct with water for twice, merge decoction liquor;
2) by step 1) gained decoction liquor is filtered successively, is concentrated, carry out secondary filter again after cold preservation, to obtain final product.
6. the preparation method being used for the treatment of the extract oral agent of chronic pharyngitis according to claim 5, is characterized in that: step 1) in, describedly decoct with water for twice in process, add water dipped medical material surface 5 ~ 15cm at every turn; Decoct after soaking 20 ~ 40min after first time adds water; Each decocting time is 0.5 ~ 1.5h.
7. the preparation method being used for the treatment of the extract oral agent of chronic pharyngitis according to claim 5, is characterized in that: step 2) in, described concentrating refers to that being concentrated into relative density is 1.07 ~ 1.20.
8. the preparation method being used for the treatment of the extract oral agent of chronic pharyngitis according to claim 5, is characterized in that: step 2) in, the temperature of described cold preservation is 4 DEG C, and cold preservation time is 12 ~ 36h.
9. the preparation method being used for the treatment of the extract oral agent of chronic pharyngitis according to claim 5, is characterized in that: step 2) in, also carry out thin up after secondary filter; Described thin up refers to that adding purified water dilutes; The amount adding purified water is: every 0.5 ~ 1.5g raw material of Chinese medicine correspondence adds water 1ml.
10. the preparation method being used for the treatment of the extract oral agent of chronic pharyngitis according to claim 9, is characterized in that: step 2) in, also carry out sterilization treatment after described thin up; Described sterilization treatment is the steam sterilization 30min of employing 100 DEG C.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116870092A (en) * | 2023-08-07 | 2023-10-13 | 甘肃中医药大学 | Traditional Chinese medicine composition for treating chronic pharyngitis |
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| CN1600356A (en) * | 2003-09-23 | 2005-03-30 | 山西医科大学第一医院 | Combination of Chinese traditional medicine for curing chronic pharyngitis and preparation method |
| CN102319367A (en) * | 2011-09-19 | 2012-01-18 | 北京爱医互动科技有限公司 | Medicine used for treating chronic pharyngolaryngitis and vocal cord diseases |
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| CN1600356A (en) * | 2003-09-23 | 2005-03-30 | 山西医科大学第一医院 | Combination of Chinese traditional medicine for curing chronic pharyngitis and preparation method |
| CN102319367A (en) * | 2011-09-19 | 2012-01-18 | 北京爱医互动科技有限公司 | Medicine used for treating chronic pharyngolaryngitis and vocal cord diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116870092A (en) * | 2023-08-07 | 2023-10-13 | 甘肃中医药大学 | Traditional Chinese medicine composition for treating chronic pharyngitis |
| CN116870092B (en) * | 2023-08-07 | 2024-05-03 | 甘肃中医药大学 | Traditional Chinese medicine composition for treating chronic pharyngitis |
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