CN103417914A - TCM composition for treatment of acute renal failure - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating acute renal failure. Expressed in parts by weight, the raw material of the traditional Chinese medicine composition contains 25-150 g of raw gypsum, 12-25 g of Anemarrhena, 15-30 g of raw land, 10-25 g of honeysuckle, 10-12 g of Achyranthes bidentata, 12-18 g of raw sage, and 10 g of salvia miltiorrhiza. ~18g, turmeric 10~15g, Chuanxiong 12~18g and red peony 10~15g. The traditional Chinese medicine composition used for treating acute renal failure of the present invention has been studied for many years, and hundreds of patients have been clinically observed, and the clinical therapeutic effect is obvious. The curative effect against renal failure is affirmed. It can improve renal function, reduce blood urea nitrogen, creatinine, etc., and has the effects of clearing away heat, detoxifying, venting turbidity and saving kidneys, breaking Qi and clearing accumulation, cooling blood to stop bleeding, promoting body fluid and dredging collaterals, increasing liquid and attacking blood. .

Description

Traditional Chinese medicine composition for treating acute renal failure

technical field

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating acute renal failure. the

Background technique

Acute renal failure is a group of syndromes. Caused by a variety of etiologies, the glomerular filtration function rapidly drops below 50% of normal, blood urea nitrogen and blood creatinine rapidly increase and cause water, electrolyte disturbance, acid-base balance disturbance and acute uremia symptoms. Acute renal failure can be found in various diseases. Acute renal failure is different from chronic renal failure. If it can be diagnosed early and rescued in time, the renal function can be fully restored. If the diagnosis and treatment are delayed, it can be fatal. Prognosis is related to factors such as primary disease, age, diagnosis and treatment, whether combined with multiple organ failure, etc.

Acute renal failure, the current incidence rate remains high, a serious threat to human life and health. Clinically, once it develops to the stage of acute renal failure, the condition is severe and life hangs by a thread. Tens of thousands of patients die every year due to renal failure, especially acute renal failure. Once encountering such a situation in a remote area, there is basically nothing to do, and the patient sits and waits to die. Therefore, the state allocates huge funds every year to support research on the prevention, diagnosis, treatment and drug development of renal failure (acute and chronic), and conducts regular academic exchanges and discussions, aiming to conquer the demons that threaten human health in a relatively short period of time. The pathogenesis of acute renal failure is that due to short-term pathological changes or even necrosis of the glomerulus and renal tubules, the metabolic waste in the body cannot be eliminated, resulting in self-poisoning and even death of the patient within a short period of time. So far, western medicine and western medicine basically have no definite drug of curative effect except artificial kidney hemodialysis. The significance of finding a set of effective programs and methods for the treatment of renal failure will be far-reaching, timely and encouraging.

At present, there are also related literature reports on Chinese patent medicines for the treatment of renal failure. For example: 1. The application number is 96115017.3, and the name is "a decoction for treating acute renal failure and chronic renal insufficiency". , Polygonum multiflorum, Poria cocos, Motong, Dilong, Cordyceps, Jiazhu and so on. 2. The invention patent with the application number 03126184.1 and titled "Traditional Chinese Medicine Powder for Treating Infectious Acute Renal Failure". Made of mother and woody incense.

Contents of the invention

The technical problem to be solved by the present invention is: in view of the current high incidence of acute renal failure, no ideal effective drug treatment, high toxicity of western medicines, and difficult to determine the curative effect, the present invention provides a method for the treatment of acute renal failure. Chinese medicine composition. The medicine prescription of the present invention is reasonable in compatibility, scientific in medicine compatibility, rich in medicinal materials and medicine sources, moderate in price, convenient in obtaining materials, easy to make, and has rules to follow in syndrome differentiation. The medicine of the present invention is taken by a single person every day and the current price of the medicine is between 16 to 100. 30 yuan. It is suitable for large-scale treatment and prevention of common and frequently-occurring diseases of acute renal failure.

In order to solve the above problems, the technical solution adopted in the present invention is:

The invention provides a traditional Chinese medicine composition for treating acute renal failure, expressed in parts by weight. The raw materials of the traditional Chinese medicine composition are 25-150 g of raw gypsum, 12-25 g of Anemarrhena anemarrhena, 15-30 g of raw land, and 10-10 g of honeysuckle. 25g, Achyranthes bidentata 10～12g, raw mast 12～18g, salvia miltiorrhiza 10～18g, curcuma 10～15g, chuanxiong 12～18g and red peony root 10～15g (this drug formula is the basic formula for the treatment of acute renal failure ).

A traditional Chinese medicine composition for treating acute renal failure, expressed in parts by weight, the raw materials of the traditional Chinese medicine composition are 25-150 g of raw gypsum, 12-25 g of Anemarrhena, 15-30 g of raw land, 10-25 g of honeysuckle, Knee 10-12g, raw mast 12-18g, salvia miltiorrhiza 10-18g, turmeric 10-15g, chuanxiong 12-18g, red peony 10-15g, bellflower 10-15g, white front 10-15g, chuanbei 10-15g , Tinglizi 10-12g and almond 6-10g (the drug formula is mainly for the treatment of type Ⅰ acute renal failure).

A traditional Chinese medicine composition for treating acute renal failure, expressed in parts by weight, the raw materials of the traditional Chinese medicine composition are 25-50 g of raw gypsum, 12-25 g of Zhimu, 15-30 g of raw land, 12-20 g of honeysuckle, Knee 9-12g, Raw Mistula 10-18g, Salvia miltiorrhiza 10-18g, Curcuma 8-15g, Chuanxiong 12-25g, Radix Paeoniae Rubra 10-15g, Zhuru 10-15g and Ochre 6-9g (the drug formula Mainly for the treatment of vomiting symptoms of acute renal failure).

A traditional Chinese medicine composition for treating acute renal failure, expressed in parts by weight, the raw materials of the traditional Chinese medicine composition are 25-50 g of raw gypsum, 12-25 g of Zhimu, 12-30 g of raw land, 10-25 g of honeysuckle, Knee 9-15g, raw mast 10-18g, salvia miltiorrhiza 10-20g, turmeric 10-15g, chuanxiong 12-25g, red peony 10-18g, schisandra 12-25g and heterophylla 12-18g (the drug formula mainly It is for the treatment of asthmatic symptoms of acute renal failure).

A traditional Chinese medicine composition for treating acute renal failure, expressed in parts by weight, the raw materials of the traditional Chinese medicine composition are 25-150 g of raw gypsum, 12-25 g of Zhimu, 12-30 g of raw land, 12-25 g of honeysuckle, Knee 9-12g, Raw Mistula 12-18g, Salvia 10-20g, Curcuma 9-15g, Chuanxiong 12-25g, Chishao 10-15g, Paeonol 10-15g, Adenophora 10-15g, Dendrobium 9-15g , Rhubarb 10-30g and Ophiopogon japonicus 10-15g (the drug formula is mainly for the treatment of type II acute renal failure).

A traditional Chinese medicine composition for treating acute renal failure, expressed in parts by weight, the raw materials of the traditional Chinese medicine composition are 25-150 g of raw gypsum, 12-30 g of Zhimu, 15-30 g of raw land, 10-25 g of honeysuckle, Knee 9-15g, Raw Mistula 10-18g, Salvia miltiorrhiza 12-18g, Curcuma 9-15g, Chuanxiong 12-25g, Radix Paeoniae Rubra 10-15g, Uncaria 9-10g and Shichangpu 9-15g (the drug formula Mainly for the treatment of convulsions and wind-moving symptoms of acute renal failure).

A traditional Chinese medicine composition for treating acute renal failure, expressed in parts by weight, the raw materials of the traditional Chinese medicine composition are 50-150 g of raw gypsum, 15-30 g of Zhimu, 15-30 g of raw land, 12-20 g of honeysuckle, Knee 10-15g, raw mast 12-18g, salvia miltiorrhiza 12-20g, turmeric 9-15g, chuanxiong 12-25g, red peony 10-18g, dandelion 25-30g and forsythia 15-18g (the drug formula mainly It is the treatment of acute renal failure with severe fever symptoms).

A traditional Chinese medicine composition for treating acute renal failure, expressed in parts by weight, the raw materials of the traditional Chinese medicine composition are 30-150 g of raw gypsum, 15-30 g of Anemarrhena anemarrhena, 15-30 g of raw land, 12-25 g of honeysuckle, Knee 12-18g, Raw Mistula 12-18g, Salvia miltiorrhiza 12-20g, Curcuma 9-15g, Chuanxiong 12-18g, Radix Paeoniae Rubra 10-18g, Patrinia 15-30g, Bletilla striata 10-12g, large and small thistles each 10 ～15g, buffalo horn 10～20g and amber powder (the amber powder passes through a 20-mesh sieve, and the amber powder is taken after mixing when taking it) or 1.5g of Angong Niuhuang Wan (the drug formula is mainly used to treat type Ⅲ acute renal failure).

A traditional Chinese medicine composition for treating acute renal failure, expressed in parts by weight, the raw materials of the traditional Chinese medicine composition are 25-150 g of raw gypsum, 12-30 g of Zhimu, 15-30 g of raw land, 12-25 g of honeysuckle, Knee 10-18g, raw mast 12-18g, salvia 12-18g, turmeric 9-15g, chuanxiong 12-18g, red peony 10-15g, ginseng or American ginseng 12-15g, radix 10-18g and schisandra 12-15g Composition of 25g (the drug formula is mainly used for the treatment of shock symptoms of acute renal failure).

A traditional Chinese medicine composition for treating acute renal failure, expressed in parts by weight, the raw materials of the traditional Chinese medicine composition are 25-150 g of raw gypsum, 15-25 g of Zhimu, 15-30 g of raw land, 12-20 g of honeysuckle, Knee 9-12g, Raw Mistula 12-18g, Salvia miltiorrhiza 12-18g, Curcuma 9-15g, Chuanxiong 12-25g, Radix Paeoniae Rubra 10-15g, Rhizoma Imperatae 15-18g, Radix Notoginseng 1.5-3g (Notoginseng end pass through a 20 mesh sieve; when taking it, notoginseng powder should be taken after mixing with water) (the drug formula is mainly used to treat acute renal failure with bleeding symptoms).

The pharmacological effect of various raw materials of the present invention:

Gypsum: (heat-clearing and gunpowder medicine) tastes pungent, sweet, slightly cold in nature; returns to lung and stomach meridians. Efficacy and Indications: This product has the effects of clearing away heat and purging fire, relieving restlessness and quenching thirst, astringent and promoting granulation; Indications: stroke, cold and heat, dyspnea, dry mouth and tongue, inability to breathe, hard pain in the abdomen, eliminating evil spirits, childbirth Decubitus ulcers; in addition to seasonal qi, headache, body heat, severe heat in the triple burner, hot skin, stagnation of gas in the stomach, relieving muscle sweating, relieving thirst, dysphoria, abdominal distension, gasping, wheezing and throat heat, it can also be used as a bath soup; to treat typhoid fever and headaches such as Crack; fry tea with scallions, relieve headaches; cure ecstasy, whirling head, breastfeeding, wipe teeth and benefit teeth; remove stomach heat and lung heat, disperse yin evil, slow spleen and replenish qi; stop Yangming meridian for headaches, fever and aversion to cold , daily breastfeeding hot flashes, thirsty drinking, heatstroke hot flashes, toothache.

The main component of raw gypsum is hydrous calcium sulfate; at this time, there are still a small amount of silicic acid, aluminum hydroxide, sulfide and trace amounts of iron and magnesium.

Anemarrhena: This taste is bitter, sweet, and cold in nature; it returns to the lung, stomach, and kidney channels. Efficacy and Indications: This product has the effects of clearing heat and purging fire, promoting body fluid and moistening dryness; it is commonly used to treat febrile disease, high fever and polydipsia, cough and asthma, dry cough, constipation, bone steaming hot flashes, restlessness and insomnia, diarrhea and turbidity.

Rehmannia: namely Rehmannia glutinosa. This taste is sweet and bitter, cold in nature; enters the heart, liver, and kidney channels. Efficacy and Indications: This product has the effects of clearing heat, promoting body fluid, nourishing yin, and nourishing blood; it is commonly used to treat fever due to yin deficiency, thirst, vomiting blood, epistaxis, metrorrhagia, irregular menstruation, restless fetal movement, yin injury and constipation.

Honeysuckle: sweet in the mouth, cold in nature, enters lung, stomach meridian. Efficacy and Indications: It has the functions of clearing heat and detoxifying, evacuating wind-heat, etc. Commonly used to treat febrile diseases, fever, wind-heat cold, erysipelas, heat-toxin bloody dysentery, carbuncle, swollen furuncle, sore throat and various infectious diseases.

Modern medical research: This product contains chlorogenic acids, glycosides, flavonoids, and volatile oils; glycosides include saponins, iridoid glycosides, etc. 1. It has antibacterial and antiviral effects: it has obvious inhibitory effect on Staphylococcus aureus, hemolytic streptococcus, dysentery, typhoid, meningococcus, pneumococcus, Pseudomonas aeruginosa and influenza virus. 2. It has the function of enhancing immunity: honeysuckle can promote the transformation of lymphocytes and enhance the phagocytosis of white blood cells. 3. Anti-inflammatory and antipyretic effects: Honeysuckle can promote the release of adrenal cortex hormones and have a significant inhibitory effect on inflammation.

Achyranthes bidentata: This taste is sour, bitter, and flat in nature; enters the liver and kidney channels. Efficacy and Indications: This product has the effects of nourishing liver and kidney, strengthening bones and muscles, promoting blood circulation and stimulating menstruation, setting fire downward, diuresis and treating stranguria. Commonly used to treat waist and knee pain, flaccidity and weakness of lower limbs, amenorrhea due to stagnation of blood, dysmenorrhea, postpartum blood stasis and abdominal pain, lump in the abdomen, persistent clothes, hot stranguria, bloody stranguria, bruises, carbuncle, malignant sore, sore throat and other symptoms.

Modern pharmacological research proves that: this product contains triterpene saponins, which can be hydrolyzed to form oleanolic acid; it also contains ecdysterone, achymanthene, and adenosterone; it also contains polysaccharides, amino acids, and alkaloids , coumarins; roots contain a lot of potassium salts, betaine, sucrose, etc. This product has the effects of lowering blood pressure, lowering blood sugar, dilating blood vessels, anti-inflammatory, analgesic, enhancing gastrointestinal motility, improving liver function, and lowering serum cholesterol.

Gardenia: cold in nature, slightly bitter; enters the six meridians of the heart, liver, lung, stomach, kidney, and bladder. Efficacy and Indications: 1. Clearing stagnation and heat: gardenia is bitter in taste and mainly descends, cold in nature and clearing heat, light body enters qi, red color enters blood, good at clearing and relieving stagnation and heat. Its nature is flexed and directed downward, from top to bottom, penetrating through stagnant fire in the three energizers. It can clear all stagnant heat in the chest and diaphragm, annoyance and restlessness; 2. Purging heat and dampness: Gardenia bitterness can dry dampness, coldness can clear away heat, from the above, the dampness can be separated from the two stools, so it can clear away heat and dampness, treat dampness and heat in the upper, middle and lower triple energizers, and benefit the liver and gallbladder. And treat yellow. Damp and heat in the spleen and stomach can be used to treat aphthous halitosis, and damp and heat can be infiltrated into the bladder to control stranguria. 3. Cooling blood and stopping bleeding: Gardenia is cold in nature, enters the blood system, purifies heat and cools blood, removes heat, blood returns to meridians, cools blood, and calms and coagulates. Therefore, Gardenia purifies heat and cools blood, and is used for bleeding syndrome caused by blood heat. 4. Reducing swelling and relieving pain: Traumatic swelling and pain, skin bruises, tumbling injuries, sprains and contusions, etc., are all caused by stasis at the wound, which turns into heat, redness, swelling and pain due to stagnation. Make a paste with raw gardenia powder, flour, and rice wine, and apply it to the local area to relieve stagnation and heat dissipation, reduce swelling and activate collaterals. 5. Heat-clearing and detoxifying: gardenia is a product of bitter cold, which has the effect of clearing away heat and detoxifying, but its detoxifying power is not very strong. If it is used for high fever, irritability, coma, delirium or swollen sores with flaming fire and poison, other heat-clearing drugs are needed Combination of antidote.

Modern pharmacological studies have proved that this product contains a variety of iridoid glycosides, mainly geniposide, that is, genipin L-glucoside, with a content of up to 6%, and didhydroxygeniposide, genipin -1-β-gentiobioside, gallinaceous glycoside methyl ester, gardenia neoside, geniposide, deacetyl pyloriside methyl ester, etc.; it also contains crocin and crocenic acid , ursolic acid, etc. This product has functions of promoting gallbladder, protecting liver, promoting pancreatic secretion, lowering blood pressure, inhibiting bacteria, analgesic, and anti-inflammation;

Salvia miltiorrhiza: bitter in taste, slightly cold in nature; Guixin, liver, kidney, spleen four meridians. Efficacy and Indications: 1. Promoting blood circulation and regulating blood: Salvia miltiorrhiza is red in color, enters the heart meridian, bitter in taste and can let down. The heart governs the blood vessels, and the liver stores blood, so it can promote blood circulation and regulate menstruation. This product can mainly treat irregular menstruation, amenorrhea due to stagnation of blood, metrorrhagia and metrorrhagia, irregular movement of Chong and Ren, restless fetal movement, and continuous bleeding. Postpartum congestion, lochia and other evidence. Because this product is mildly cold in nature, it is suitable for those who are stagnant due to blood heat. It is actually an essential medicine for promoting blood circulation and regulating blood circulation. 2. Dispelling blood stasis and relieving pain: Salvia miltiorrhiza is the key medicine of the blood system, enters the heart, liver and kidney channels. If the heart loses its place, the liver blood meridian fails to dredge, the kidney is deficient and is the guest of cold and damp, resulting in stagnation of qi and blood; the syndrome of pain due to rigidity of the waist and spine, and pain, this product can break blood stasis and clear away, promote blood circulation and promote blood circulation. Congestion relieves pain. Salvia miltiorrhiza promotes blood circulation and removes blood stasis, internally it can transform viscera to stasis, and externally it can clear the meridians and sharpen the joints, so this product can be used mainly for dysmenorrhea, postpartum stagnant abdominal pain, heart and abdomen pain, accumulation of lumps and wrist congestion, hernia attacking and stopping strokes Uncompensated, pain due to arthralgia and fistula in the ankle, or joint pain caused by stagnation of blood stagnation and other congestion pain. It can eliminate the lump in the abdomen and break the accumulation, and it can also relieve the numbness and strengthen the waist and knees. The foundation of its effectiveness all stems from the merit of promoting blood circulation and removing blood stasis, and promoting circulation. 3. Cooling blood and reducing swelling: Salvia miltiorrhiza enters the heart and liver meridians, and its nature is cold, so it can cool blood. This product is good at invigorating blood and cooling blood, and can dissipate blood stasis. 4. Nourishing blood and calming the nerves: the heart governs the blood and the mind. Therefore, this product can nourish the heart and calm the mind, nourish the blood and calm the nerves, and can clear the heart and eliminate troubles. It can not only treat the symptoms of forgetfulness, palpitations and restlessness caused by insufficient effort, but also treat the symptoms of febrile disease, restlessness and insomnia. 5. Enriching blood and nourishing Qi: Salvia miltiorrhiza enters the blood with red color, which can activate blood and nourish blood. This product is both offensive and tonic, so it has the title of yin to yang medicine.

Modern pharmacological studies have proved that Danshen contains tanshinone, protocatechuic aldehyde, protocatechuic acid, danshensu, vitamin E and other ingredients. Danshen can expand coronary arteries, increase coronary flow, improve myocardial ischemia, infarction and heart function, regulate Heart rhythm, and can expand peripheral blood vessels, improve microcirculation; can improve the body's ability to withstand hypoxia; anticoagulant, promote fibrinolysis, inhibit platelet aggregation, and inhibit thrombosis; can reduce blood lipids, inhibit coronary atherosclerosis formation ; Can inhibit or reduce liver cell degeneration, necrosis and inflammatory response, promote liver cell regeneration, and have anti-fibrosis effect; can shorten the recovery period of red blood cells and hemoglobin, increase reticulocytes, promote tissue repair, and accelerate fracture healing; It has an inhibitory effect on the central nervous system; has an anti-tumor effect; can enhance the immune function of the body; can lower blood sugar; has an inhibitory effect on various bacteria such as Mycobacterium tuberculosis.

Curcuma: bitter in taste, cold in nature, enters the liver, heart and lung meridians. This product has the effects of promoting qi and removing blood stasis, clearing away heart-fire and relieving depression, promoting gallbladder and reducing jaundice. Commonly used to treat amenorrhea dysmenorrhea, chest and abdomen distension, tingling pain, febrile coma, epilepsy, madness, jaundice and red urine.

Modern pharmacological studies have proved that this product mainly contains volatile oils, including camphene, camphor, sesquiterpenes, and contains curcumin, demethoxycurcumin, bisdemethoxycurcumin, curcumone and fragrant base ginger flavonoids. It also contains starch, fatty oil, rubber, yellow dye, carvone and phellandrene. Its active ingredient is p-tolyl-methyl hydroxymethyl curcumin. This product has anti-lipid, anti-fungal and other effects.

Rhizoma Chuanxiong: warm in nature, pungent in taste, bitter; enters the liver, gallbladder, bladder, and triple burner meridian. Efficacy and indications: 1. Promoting qi to relieve depression: this product is pungent and fragrant, and good action powder enters the Jueyin Liver Meridian, soothes stagnation of the liver, promotes qi circulation and relieves pain. 2, expelling wind and dampness: this product is pungent and capable of dispersing, fragrance is bitter and dry, expelling wind and cold and drying damp, often can be used for the syndromes such as anemofrigid cold, anemofrigid-damp arthralgia, anemofrigid headache. 3. Promoting blood circulation and relieving pain: This product is a medicine for qi in the blood, which is good at promoting qi and activating blood circulation, warming the meridians and relieving pain. It can often be used for postpartum haemorrhage, postpartum abdominal pain, blood stasis and amenorrhea. 4. Reduce swelling and expel pus: This product promotes blood circulation to reduce swelling, expels pus and promotes regeneration, and can be used for carbuncle, swelling and pain from falls.

Radix Paeoniae Rubra: This product contains paeoniflorin, paeoniflorin, oxidized paeoniflorin, benzoylpaeoniflorin, paeoniflorinone, paeoniflorin, gallic tannin, benzoic acid, volatile oil, fatty oil, resin, etc. This product can dilate coronary arteries and increase coronary blood flow; water extract of Radix Paeoniae Rubra, Radix Paeoniae Rubra, components of Radix Paeoniae Rubra and their derivatives can inhibit platelet aggregation; Heavy; contained paeoniflorin has sedative, anti-inflammatory and analgesic effects; peony liquid extract and paeoniflorin have anticonvulsant effects; red peony and paeoniflorin have antispasmodic effects; red peony has obvious enhancement effect on the synthesis of liver cell DNA, It has a strong inhibitory effect on a variety of pathogenic microorganisms.

Platycodon grandiflorum: This taste is bitter, pungent, slightly warm in nature; enters the lung meridian. Efficacy and Indications: This product has the effects of relieving cough and eliminating phlegm, clearing the lungs, draining pus, relieving throat, benefiting the five internal organs, nourishing qi and blood, nourishing the five labors, and nourishing qi. Commonly used to treat cough with excess phlegm, sore throat, lung abscess and vomiting of pus, chest fullness and hypochondriac pain, dysentery and abdominal pain, sores of the mouth and tongue, red eyes and swelling pain, urinary incontinence and other symptoms.

Baiqian: pungent, bitter in taste, slightly warm in nature; returns to the lung meridian. Efficacy and Indications: This product has the effects of lowering Qi, resolving phlegm, and relieving cough. Commonly used for coughing with excess phlegm and asthma. This product is slightly warm but not dry, good at dispelling phlegm, lowering lung qi to calm cough and asthma, whether it is cold or hot, exogenous and internal injury, new cough and chronic cough.

Chuanbei: This taste is sweet and flat, cool in nature; it belongs to the lung meridian and stomach meridian. Efficacy and Indications: Chuanbei has the effect of moistening lung, relieving cough, resolving phlegm and asthma, clearing away heat and resolving phlegm. Chuanbei has antitussive effect, expectorant effect, antihypertensive effect, and certain antibacterial effect. Chuanbei is the dried bulb of Liliaceae Fritillaria Chuanbei, Dark Purple Fritillaria, Gansu Fritillaria, and Suosha Fritillaria.

Tinglizi: this taste is pungent, warm in nature; returns to the lung meridian. Efficacy and Indications: This product has the effects of warming the lungs, removing phlegm and promoting Qi, dispelling stagnation, dredging collaterals and relieving pain. It is often used for symptoms such as cold phlegm, dyspnea and cough, distending pain in the chest and hypochondriac, phlegm stagnation in the meridian, joint numbness and pain, phlegm-damp flow, gangrene and swollen toxin.

Almond: This product is mild in nature and bitter in taste. Return lung, large intestine two warps. Efficacy and Indications: This product has the effects of relieving cough, relieving asthma, moistening intestines and laxative. Commonly used to treat cough, asthma, intestinal dryness and constipation.

Jiang Zhuru: Also known as Zhuru, it is the middle layer scraped out from the stems of the Gramineae plants such as Pachyphyllum edulis, Bambusa chinensis, and Bambusa grandis. This product is sweet in taste and slightly cold in nature; it belongs to the Spleen, Stomach and Gallbladder meridians. Efficacy and Indications: This product has the effects of clearing heat, cooling blood, resolving phlegm, and stopping vomiting; commonly used to treat dysphoria, vomiting, hiccups, cough with phlegm heat, vomiting blood, epistaxis, metrorrhagia, nausea, restlessness, convulsions, etc. .

Substitute ochre: this taste is sweet, property is flat, returns Liver Channel, Stomach Channel, Heart Cell Channel. Efficacy and Indications: This product has the effects of calming the liver and suppressing adverse events, cooling blood and stopping bleeding, etc.; it is commonly used to treat nausea, vomiting, nausea, asthma, convulsions, vomiting blood, epistaxis, intestinal wind, hemorrhoids, metrorrhagia and leucorrhea, etc. .

Fructus Schisandra: This product is warm in nature; sour in taste and sweet in taste. Go into lung, stomach, heart three warps. Efficacy and Indications: 1. Astringe the lungs and nourish the kidneys: the acid of this product can astringe, warm and moist in nature, enter the lung and kidney meridian, astringe lung qi on the upper side, and nourish kidney yin on the lower side. It is suitable for chronic cough due to lung deficiency and lung and kidney deficiency. , has the effect of relieving cough and relieving asthma. 2. Promoting body fluid and suppressing sweat: Schisandra chinensis is sweet and sour to transform yin, can nourish and promote body fluid, enter the heart and lung meridian, benefit lung yin, restrain heart yin and stop sweating. It is suitable for syndromes such as thirsty wounds, spontaneous sweating, night sweats, and diabetes. 3. Astringent essence and antidiarrheal: Schisandra chinensis is sweet and sour, enters the kidney meridian. It is sweet and tonic, and sour can restrain astringency, so it has the effects of tonifying kidney, astringent essence, astringent and antidiarrheal. It can be used to treat symptoms of kidney deficiency, weak essence, and astringent hind yin, such as: nocturnal emission, slippery essence, and persistent diarrhea. 4. Calm the mind and calm the nerves: Schisandra chinensis is sweet and sour, enters the heart and kidney meridians, can benefit the yin of the heart and kidney and calm the mind and tranquilize the nerves. Commonly used to treat palpitations, insomnia, dreaminess, restlessness and other symptoms.

Radix Pseudostellariae: sweet in taste, slightly bitter, slightly warm in nature; enters the heart, spleen, and lung meridians. Efficacy and indications: This product has the effects of nourishing the spleen and lung, replenishing qi and promoting body fluid. Commonly used to treat cough due to lung deficiency, lack of food due to spleen deficiency, heart palpitations, convulsions, edema, thirst, mental fatigue and other diseases.

Peony: also known as Moutan. This taste is bitter and pungent, slightly cold in nature; Guixin, Liver, Kidney and Lung meridians. Efficacy and Indications: This product has the effects of clearing away heat and cooling blood, promoting blood circulation and dispelling stasis; it is commonly used to treat febrile diseases with heat entering the blood, spots, vomiting, fever in the late stage of febrile disease, hot flashes caused by yin deficiency and bone steaming, blood stagnation Amenorrhea, dysmenorrhea, carbuncle sore, tumbling pain, rheumatism-heat arthralgia.

Radix Ginseng: This taste is sweet, slightly bitter, slightly cold in nature; enters the lung and stomach meridian. Efficacy and Indications: This product has the functions of clearing heat and nourishing yin, moistening lung and relieving cough. Commonly used to treat bronchitis, whooping cough, cough due to lung heat, yellow and thick expectoration and other symptoms.

Dendrobium: Also known as Dendrobium orchid, this product has the effects of nourishing the stomach and promoting body fluid, nourishing yin and clearing away heat. It has the functions of strengthening the body, nourishing the spleen and stomach, protecting the liver and gallbladder, clearing deficiency and heat, inhibiting tumors, and nourishing the skin.

Rhubarb: This taste is bitter, cold in nature, it belongs to the stomach meridian, large intestine meridian, liver meridian and spleen meridian. Efficacy and Indications: This product has the functions of attacking stagnation, clearing damp-heat, purging fire, cooling blood, dispelling blood stasis, detoxifying, etc.; it is mainly used to treat excess heat and constipation, hot knot in the chest, damp-heat diarrhea, jaundice, gonorrhea, edema, abdominal fullness, and dysuria Wait for certificate.

Uncaria: This taste is sweet and bitter, and slightly cold in nature; it belongs to the liver meridian and heart meridian. Efficacy and Indications: This product has the effects of clearing away heat and calming the liver, quenching wind and relieving convulsions, etc. It is commonly used to treat infantile convulsions, night cry, excessive heat and wind, eclampsia, liver-yang dizziness, liver-fire head pain and other syndromes.

Shichangpu: this taste is pungent, bitter, warm in nature; Guixin meridian, stomach meridian. Efficacy and indications: This product has the effects of reducing dampness and appetizing, resuscitating phlegm, refreshing and improving intelligence; it is often used for abdominal pain without hunger, dysentery, coma, epilepsy, and forgetful deafness. Regulating qi, promoting blood circulation, dispersing wind, removing dampness. Treatment of epilepsy, syncope due to phlegm, febrile coma, forgetfulness, air-occlusion deafness, dysphoria, stomachache, abdominal pain, anemofrigid-damp arthralgia, carbuncle and swelling poison, bruises and other syndromes.

Dandelion: This product contains dandelion sterol, choline, inulin, pectin; C et al. Pharmacological effects of this product: 1. It has a certain bactericidal effect on pneumococcus, meningococcus, diphtheria bacillus, Pseudomonas aeruginosa, Proteus, Shigella, typhoid bacillus, etc. and catarrhal bacteria; Inhibitory effect; 2. Hepatoprotective and choleretic effect; 3. Anti-gastric ulcer effect; 4. This product has anti-human lung cancer effect; 5. It has the effect of promoting women's milk secretion.

Forsythia: bitter in taste, slightly cold in nature; enters the six meridians of the heart, liver, gallbladder, stomach, triple burner, and large intestine. Efficacy and Indications: This product has the effects of clearing heat and detoxifying, reducing swelling and dissipating stagnation; it is commonly used to treat carbuncle, scrofula, mastitis, erysipelas, wind-heat cold, febrile disease onset, warm heat and other syndromes.

Modern medical research: the fruit of this product contains forsythol, sterol compounds, saponins (non-hemolytic), flavonol glycosides, and moss resinol glycosides, etc.; the peel contains oleanolic acid. This product has pharmacological effects such as antibacterial, cardiotonic, diuretic, and antiemetic. Forsythia is commonly used to treat acute wind-heat cold, carbuncle sore, lymph node tuberculosis, and urinary tract infection.

Patrina: This taste is pungent, bitter, and slightly cold in nature; it returns to the Liver, Stomach and Large Intestine meridians. Efficacy and Indications: This product has the functions of clearing heat and detoxifying, cooling blood, eliminating carbuncle and discharging pus, dispelling blood stasis and relieving pain; it is commonly used to treat intestinal abscess, lung abscess with high fever, cough and spit pus and blood, heat toxin sore boil, sore furuncle pain and swelling, chest and abdomen pain , Appendicitis, enteritis, dysentery, postpartum abdominal pain, dysmenorrhea, etc.

Bletilla striata: This taste is bitter, sweet, astringent, slightly cold in nature; it returns to the lung, liver and stomach meridians. Efficacy and Indications: This product has the effects of nourishing the lung, stopping bleeding, detumescence, promoting granulation, and suppressing sores; it is commonly used to treat lung injury, hemoptysis, epistaxis, hemorrhage from gold sores, carbuncle and gangrene, ulcer pain, burns from soup fire, chapped hands and feet, etc. .

Da Ji: This taste is sweet, bitter, non-toxic, cool in nature; Guixin Meridian and Liver Meridian. Efficacy and Indications: Often control hematemesis, epistaxis, hematuria, stranguria with blood, metrorrhagia, leukorrhagia, intestinal wind, intestinal ulcer, carbuncle ulcer swelling poison, furuncle and other syndromes.

Small thistle: This taste is sweet, bitter, cool in nature; Guixin meridian and liver meridian. Efficacy and Indications: This product has the effects of cooling blood to stop bleeding, dispelling blood stasis and reducing swelling. It is commonly used in epistaxis, hematemesis, hematuria, hematochezia, metrostaxis, traumatic bleeding, carbuncle and sores.

Both large and small thistles have the effects of clearing away heat and detoxification, reducing inflammation, stopping bleeding, restoring liver function, and promoting liver cell regeneration. They are suitable for acute febrile inflammatory bleeding, jaundice, hepatitis, hot stranguria, and hematuria.

Buffalo horn: It is a substitute for rhino horn in traditional Chinese medicine. This taste is bitter, salty, and cold in nature; Guixin, Liver, Spleen and Stomach meridians. Efficacy and Indications: This product has the effects of clearing heat, cooling blood, detoxifying, calming convulsions, etc. It is commonly used to treat febrile headaches, coma due to heat, rashes, hematemesis, epistaxis, yellowing of stasis and heat, convulsions in children and sore throat Pain, aphtha of the mouth and other symptoms. The functions of this product are heat-clearing, cooling blood, calming convulsions, and detoxification. Control typhoid fever and febrile epidemic heat into the blood system, panic, irritability, delirium, macule, jaundice, vomiting blood, epistaxis, bleeding, carbuncle and swelling.

Amber powder: 20 mesh sieve.

Amber: This product is sweet in taste and mild in nature; efficacy and indications: this product has the effects of calming, diuresis, and promoting blood circulation; it is commonly used to treat convulsions, epilepsy, heart palpitations, insomnia, dysuria, dysuria, hematuria, and amenorrhea.

Ginseng: warm in nature, sweet in taste, slightly bitter; enters the spleen and lung meridians. Efficacy and Indications: 1. Replenish Qi and rescue: Ginseng greatly invigorates vitality and strengthens the root, so it has the effect of rescuing collapse. 2. Soothe the nerves and calm the palpitations: Ginseng nourishes the five internal organs, soothes the spirit, calms the soul, and stops palpitations. 3. Cultivate qi and blood: Ginseng nourishes qi and blood, cultivates the root and strengthens the essence. 4. Invigorating Qi and relieving asthma: Ginseng has a mild smell, nourishes both lungs and kidneys, and has the effect of relieving asthma due to deficiency. 5. Producing body fluid and quenching thirst: Ginseng treats excessive thirst, excessive sweating, shortness of breath and fatigue caused by two injuries of qi and body fluid. Reusing ginseng can benefit the effect of qi and body fluid. 6. Tonify the middle and replenish qi. 7. Tonifying the kidney and nourishing the vital energy: Ginseng greatly invigorates the vital energy, boosts the spirit, and produces body fluid. It must be used for those who have been ill for a long time and will lose their vital energy. It is often taken by those who want to restore the vital energy after illness. , all rely on its nourishing and strong power. 8. Strengthen the body and eliminate evil.

American ginseng: cold in nature, pungent, sweet, and bitter in taste; enters the five meridians of the heart, lung, stomach, kidney, and large intestine. Efficacy and Indications: 1. Invigorating Qi and Yin: This product has the function of nourishing Qi and nourishing Yin, and it often treats cough due to Qi deficiency, internal injury and quenches one's thirst. 2. Clearing away heat and promoting body fluid: This product is sweet and cold in nature. It not only removes the qi component, but also enters the blood component. It is an essential medicine for replenishing qi and promoting body fluid, nourishing yin and clearing away heat. 3. Heat-clearing and hemostasis: This product clears away heat and promotes body fluid, can be used to treat hyperactivity of fire due to yin deficiency, burns and blood-heat bleeding syndrome, and mainly treats hemoptysis due to lung heat, and blood in the stool due to intestinal heat.

Ophiopogon japonicus: slightly bitter in taste, sweet in nature, enters the heart, lung, and stomach meridians. Efficacy and Indications: This product has the effects of nourishing yin and promoting body fluid, moistening lung and clearing heart-fire. It is commonly used to treat dry cough due to dryness of the lung, consumptive cough due to yin deficiency, sore throat due to obstruction of the throat, thirsty body fluid wound, internal heat and thirst, vexation and insomnia, intestinal dryness and constipation.

Modern pharmacological studies have proved that this product contains a variety of steroidal saponins, ophioposides A, B, C, and D, and the aglycones are pseudophyllosides, and it also contains ophioposides B', C', and D'. Aglycones are all diosgenin; still contain a variety of flavonoids: such as Ophiopogon japonicus methyl flavanone A, B, Ophiopogon japonicus flavanone A, Ophiopogon japonicus flavone A, B, Ophiopogon japonicus methyl flavanone A, B ; In addition, 5 high isoflavone compounds were obtained. This product has the functions of improving immune function, inhibiting a variety of bacteria, enhancing the function of the pituitary adrenal cortex, improving the adaptability of the body, anti-arrhythmia and expanding peripheral blood vessels, improving hypoxia resistance and lowering blood sugar.

Rhizoma Imperata: This taste is sweet, cold in nature, enters the lung, stomach, and small intestine meridians. Efficacy and Indications: This product has the effects of clearing away heat and cooling blood, stopping bleeding, clearing away heat, and diuresis; it can be used to treat fever, polydipsia, hematemesis, epistaxis, dyspnea due to lung heat, regurgitation of stomach heat, gonorrhea, dysuria, edema, jaundice, etc. . the

Modern medical research: This product contains a large amount of sucrose, glucose, a small amount of fructose, xylose, citric acid, oxalic acid, malic acid, etc.; it also contains starch. From the rhizomes of Imperata praecox, Arunin, Imperatae, Fernol, Glycerol, Pulsatillae, etc. are isolated. This product has diuretic, antibacterial, hemostatic, sedative, antipyretic and analgesic effects.

Panax notoginseng: also known as Panax notoginseng, warm in nature, sweet in taste, slightly bitter, non-toxic; enters the three meridians of liver, stomach and large intestine. Efficacy and Indications: 1. Hemostasis and blood stasis dispelling: this product is good at hemostasis and blood stasis dispelling, and is now commonly used to treat blood syndromes, such as metrorrhagia, postpartum hemorrhage, persistent lochia, traumatic hemorrhage and other syndromes. 2. Promoting blood circulation and reducing swelling: This taste is bitter, warm in nature, and the bitterness releases the temperature, and when it enters the blood, it promotes blood circulation and removes blood stasis, reduces swelling and swelling, and is used to treat traumatic injuries and unknown carbuncles. 3. Dispelling blood stasis and relieving pain: This product promotes blood circulation and removes blood stasis, reduces swelling and relieves pain. It is used to control blood stasis pain, pain caused by fluttering damage, carbuncle pain and other symptoms, and the analgesic effect is the best.

The traditional Chinese medicine composition used for treating acute renal failure has the functions of clearing away heat, detoxifying, purging turbidity and saving kidneys, dispelling qi and clearing accumulation, cooling blood to stop bleeding, promoting body fluid and dredging collaterals, increasing liquid and attacking blood. For those with flaming heat and toxins and persistent high fever, follow the experience of Zhang Xichun in the Qing Dynasty to re-use gypsum, take its characteristics of clearing away heat without harming the body, and each dose can be up to 500g. Dandelion, honeysuckle, forsythia, shengzhizi, shengdi, anemarrhena, heat-clearing, promoting body fluid and increasing its liquid, and the source of qi. The degeneration and necrosis of glomerulus and renal tubules belong to the syndrome of blood stasis in traditional Chinese medicine, so salvia miltiorrhiza, red peony root, and Chuanxiong are used to clear heat and cool blood, activate blood circulation, and dredge collaterals. The purpose of functional recovery. Drugs for promoting blood circulation and removing blood stasis can inhibit or reduce allergic damage, reduce glomerular capillary permeability, dilate renal blood vessels, increase renal blood flow, and promote the reversal of disused nephrons. Salvia miltiorrhiza is an oxygen free radical scavenger. ARF has a certain relationship with oxygen free radicals. Salvia miltiorrhiza can also regulate immunity, improve microcirculation, promote fibrin degradation, prevent cell inflammation, and resist lipid peroxidation. It can prevent or block The formation of disseminated intravascular coagulation (DIC); traditional Chinese medicines such as salvia miltiorrhiza and chuanxiong have a good preventive effect on acute renal failure in the initial stage of the experiment. Therefore, the combination of the Chinese medicine composition of the present invention has not only flexibly utilized the program of dialectical treatment in traditional Chinese medicine, but also an organic unity of combining dialectical syndrome and disease differentiation. The reason why the pharmaceutical composition of the present invention has a positive therapeutic effect on this disease is that it has antibacterial, antiviral, prevention and treatment of immune kidney damage, improves microcirculation, increases renal blood flow, and promotes the absorption of renal blood stasis and renal tubular epithelial damage. cells, early repair and regeneration of necrotic cells. The pre- and post-observation results of ALT and AST confirmed such effects.

The traditional Chinese medicine composition of the present invention has the advantages of complete prescription compatibility with monarchs, ministers and adjuvants, precise medicinal power and flexible application, and has obvious characteristics of traditional Chinese medicine. Therefore, the traditional Chinese medicine composition of the present invention has an obvious therapeutic effect on renal failure.

TCM syndrome differentiation:

Excessive lung-stomach heat type (Type I): anuria, cough, coughing up yellow mucus sputum or phlegm noise in the throat, hot face, thirsty, red tongue, thin yellow or yellow thick and dry fur, stringy and rapid pulse; Therapeutic principles: Qingxuan lung and stomach.

Qi Ying two burnt type (Ⅱ type): anuria, high fever, sweating, flushed face, upset, burning all over the body, great thirst or abdominal pain, refusal to press, dry stool, incomprehensible for several days, or delirium, deep crimson tongue, The fur is thin, yellow, dry or scorched black, and the pulse is rapid or rapid; the treatment principle: clearing away heat and cooling blood.

Exuberant toxic heat, hemorrhage and closure type (Type Ⅲ): anuria, stupor or coma without speaking, tongue convulsion, limbs, dry lips, chest and abdomen scorching heat, dense rash on muscles and abdomen or epistaxis and blood in stool, tongue atrophy , deep crimson and prickly prickles everywhere, rapid pulse; treatment principles: detoxification, resuscitation, cooling blood.

The above-mentioned Chinese medicine composition of the present invention: take grams as the unit, prepare according to the above-mentioned prescription, put the prepared various raw materials into a frying pan, add water 8 to 10 times the total amount of each raw material for heating, boil and then decoct Boil for 30-40 minutes, decoct repeatedly twice, mix and filter the medicinal liquid obtained after the two decoctions, and obtain a medicinal decoction for treating acute renal failure after filtering. If the formula contains oral Chinese medicines (for example: amber powder, Angongniuhuang pills, Panax notoginseng powder, etc.), other Chinese medicines except oral medicines can be decocted. The method of taking the decoction: take gram as the unit, 1-2 doses per day, two or more times a day in the morning and evening according to the condition, take it warmly, and take 150-200ml of the decoction each time. The decoction can also be industrialized. the

Positive beneficial effect of the present invention:

1. The Chinese medicinal composition used for the treatment of acute renal failure of the present invention has been studied for many years, and hundreds of patients have been clinically observed, and the clinical therapeutic effect is obvious. The curative effect against renal failure is affirmed. It can improve renal function, reduce blood urea nitrogen, creatinine, etc., and has the effects of clearing away heat, detoxifying, venting turbidity and saving kidneys, breaking Qi and clearing accumulation, cooling blood to stop bleeding, promoting body fluid and dredging collaterals, increasing liquid and attacking blood. .

2. Utilize the traditional Chinese medicine composition of the present invention to treat 50 cases of acute renal failure with hemorrhagic fever with renal syndrome. The detailed statistics are as follows:

Methods: 98 patients with acute renal failure with hemorrhagic fever with renal syndrome were randomly divided into two groups. Control group 48 cases were treated with western medicine and western medicine, including supportive treatment, diuresis etc.; Observation group 50 cases took the Chinese medicine composition of the present invention (medicine composition: raw gypsum, Anemarrhena, rehmannia glutinosa, honeysuckle, Achyranthes bidentata, raw gardenia, salvia miltiorrhiza, eucalyptus Jin, Ligusticum Chuanxiong and Radix Paeoniae Rubra, etc.), the course of treatment was 1 week. Changes in urine volume, blood urea nitrogen, bleeding, renal function, and consciousness were observed in the two groups before and after treatment. Renal biopsy was performed in some patients.

Treatment results: After treatment, the symptoms and signs of the two groups were improved, and the observation group was better than the control group (x ² =14.16, p<0.05); the total effective rate of the observation group (92.0%) was better than that of the control group (60.42%, x ² =18.19, p<0.01); the histopathological changes of the observation group were slightly better than those of the control group, but there was no significant difference. Conclusion: The traditional Chinese medicine composition of the present invention can significantly improve microcirculation, increase renal blood flow, improve renal function and the like.

The emergence of renal failure often indicates that hemorrhagic fever with renal syndrome has reached a critical stage, so far, stagnation of qi and blood stasis, retention of water and dampness, loss of qi transformation, and difficulty in urinating. The key to the treatment of HFRS is the success of ARF rescue. Aiming at the pathogenic characteristics of the disease caused by heat, poison, dampness, stasis and stagnation of the kidney. The traditional Chinese medicine composition studied in the present invention treats 50 patients with HFRS complicated with ARF, and the curative effect is relatively significant. The content of the clinical trial is as follows.

(1) Materials and methods:

Objects: 98 patients with HFRS (50 confirmed by RIA, 28 confirmed by ELISA, and 20 confirmed by FQ-PCR) complicated with ARF were admitted from February 1996 to October 2012. Diagnosis is based on relevant information ( Infectious Diseases, edited by Yang Shaoji, first edition, Beijing, People's Health Publishing House, 2005, 78-73 ). There were 70 male patients and 28 female patients, aged 27 to 58 years old, with an average of 32.56±16.06 years old. The course of disease on admission was 6 to 12 days, 70 cases were severe, 28 cases were critical, anuria was 48 to 124 hours, with an average of 52.8 hours. 98 cases were randomly divided into a treatment group of 50 cases and a control group of 48 cases. There was no statistical difference in gender, age, and condition between the two groups, which were comparable.

TCM syndrome differentiation: Excessive lung and stomach heat type (Type Ⅰ): anuria, cough, coughing up yellow mucus sputum or phlegm sound in the throat, hot face, thirst, red tongue, thin yellow or yellow thick and dry pulse, The number of strings, the treatment principle: Qingxuan lung and stomach. Qi Ying two burnt type (Ⅱ type): anuria, high fever, sweating, flushed face, upset, burning all over the body, great thirst to drink or abdominal pain and refusal to press, dry stool, incomprehensible for several days, or delirium, deep crimson tongue, The fur is thin, yellow, dry or scorched black, and the pulse is rapid or rapid. The treatment principle is: clearing away heat and cooling blood. Exuberant toxic heat, hemorrhage and closure type (Type Ⅲ): anuria, stupor or coma without speaking, tongue convulsion, limbs, dry lips, chest and abdomen scorching heat, dense rash on muscles and abdomen or epistaxis and blood in stool, tongue atrophy , deep crimson and prickly prickles all over the place, rapid pulse, treatment principles: detoxification, resuscitation, cooling blood.

Treatment method: The control group adopts comprehensive measures such as supportive therapy, stabilizing the internal environment, improving microcirculation, increasing renal blood flow, promoting diuresis, and symptomatic treatment. Diuretic options: benzazolidin + furtimide, 654-2 (or dopamine) + furtimid, benzazolidin + butyramide, etc. On the basis of western medicine treatment, the observation group took the decoction of the traditional Chinese medicine composition of the present invention according to dialectics. 12g, 12-18g raw mast, 10-18g salvia, 10-15g turmeric, 12-18g Chuanxiong and 10-15g red peony. Addition and subtraction: type Ⅰ plus Platycodon grandiflorum 10-15g, Baiqian 10-15g, Chuanbei 10-15g, Tinglizi 10-12g and almond 6-10g; vomiting symptoms plus bamboo 10-15g and ochre 6-9g ( The amount of relevant raw materials in the basic prescription should be adjusted); for asthma symptoms, add Schisandra 12-25g and Radix Pseudostellariae 12-18g (the dosage of relevant raw materials in the basic prescription should be adjusted); for type II, add paeonol 10-15g, Adenophora 10 ～15g, Dendrobium 9～15g, Rhubarb 10～30g and Ophiopogon japonicus 10～15g (in the basic prescription, the dosage of relevant raw materials should be adjusted); Twitching wind plus Uncaria 9～10g and Shichangpu 9～15g (in the basic prescription The amount of relevant raw materials should be adjusted); for patients with severe heat, 50-150g of gypsum, 25-30g of dandelion, 25-30g of rehmannia, and 15-18g of forsythia (the dosage of relevant raw materials in the basic formula should be adjusted); 15-30g of soy sauce, 10-12g of bletilla striata, 10-15g of each thistle, 10-20g of buffalo horn, 1.5g of amber powder or Angong Niuhuang pill (amber powder 20-mesh sieve) 12-15g of ginseng or American ginseng, 10-18g of Radix Ophiopogon japonicus and 12-25g of Schisandra chinensis (the amount of relevant raw materials in the basic prescription is adjusted); for bleeding, add 15-18g of rhizoma rhizome and Radix Notoginseng (20 mesh sieve) 1.5-3g (washed in water) (the amount of relevant raw materials in the basic formula should be adjusted). The above-mentioned prescriptions and medicines are tailored according to the symptoms of the disease and used flexibly. Conventional decoction method, take 150-300ml of juice for each dose, and take 1-4 doses a day.

Test indicators: Before treatment and after admission, the patients routinely do laboratory tests 1 to 3 times a day: plasma urea nitrogen (BUN), serum creatinine (Cr), alanine aminotransferase (ACT), aspartate aminotransferase ( AST) was detected with an automatic biochemical analyzer TAR GA300 made in Italy; the patient's blood was detected by RIA, ELISA, and fluorescence quantitative-polymerase chain reaction (FQ-PCR) respectively, and the operation was performed according to the instructions. The kit was provided by Shanghai Huatai Bioengineering Industry Co., Ltd. Produced by the company; some patients underwent renal biopsy, and the renal biopsy specimens were fixed with 10% formaldehyde, embedded in paraffin, stained with HE, and examined by light microscopy. All tested blood was divided into 2 parts each time venous blood was drawn, and 2 people operated and recorded at the same time.

Efficacy evaluation:

Significantly effective: After 24-48 hours of treatment, the 24-hour urine output > 1000ml, and the condition is obviously improved;

Effective: 24-hour urine output > 300ml, the condition has improved;

Ineffective: 24-hour urine output <300ml, no improvement or worsening condition.

±s表示，采用t检验；计数资料用x²检验。 Statistical processing: measurement data with

±s said, using t test; count data using x ² test.

(2) Treatment results:

Therapeutic effect: after the observation group took the Chinese medicine composition decoction of the present invention, 38 cases (76.0%) were markedly effective, 8 cases were effective (16.0%), and 4 cases (8.0%) were ineffective, and the total effective rate was 92.0%; 5 cases (50.0%) were effective, 5 cases were effective (10.42%), 21 cases were ineffective (43.75%), and the total effective rate was 60.42%. The observation group was better than the control group (x ² =18.19, P<0.01), see table 1.

Changes in main symptoms and signs: After 1 week of treatment, bleeding, anuria, hypotensive shock, hypertension, and mental status in the observation group were significantly improved, which were better than those in the control group (x ² =14.16, P<0.05), see Table 2.

Renal function and biochemical changes: After 1 week of treatment, the normalization rate of white blood cells, red blood cells, and platelets in the observation group (79.59%) was significantly different from that in the control group (46.38%) (x ² =9.18, P<0.05); blood urea ( BUN), creatinine (Cr), ALT, and AST were significantly different between the two groups (x ² =12.96, P<0.01). See Table 3.

Histopathological changes: 32 cases of renal biopsies were performed on admission, 1 week after treatment and within 3 months after discharge in the observation group and 5 cases in the control group. Changes such as sex and hemorrhage were gradually alleviated. After treatment in the control group, inflammation and hemorrhage of glomeruli and renal tubules were alleviated, but there was no significant difference.

Treatment results:

HFRS belongs to the category of "summer temperature" in febrile diseases in Chinese medicine, and predecessors have made a comprehensive discussion on it. "Suwen·Xuanming Wuqi Chapter" says: If the bladder is unfavorable, it will lead to constipation, and if you don't make an appointment, you will drown. Ye Tianshi in the Qing Dynasty pointed out: "When the heat is received from the upper part, it first invades the lungs and reverses the pericardium." It can be seen that the lesion of this disease is mainly in the bladder, involving the lungs, pericardium, stomach, kidneys and other organs. The pathogenic factors are heat, poison, dampness, and stasis. Gasification is unfavorable, and gasification has no source for injuring body fluid and consuming liquid. According to the fact that dampness is a yang evil, it is easy to injure body fluid and consume fluid, especially in the later stage, the pathogenic characteristics of fluid depletion often occur. In terms of treatment, it is necessary to clear away heat and detoxify, and also take "preserving body fluid and nourishing fluid" as the first priority. Most of the heat-clearing and detoxifying products are bitter and cold, which can easily damage the stomach and harm the righteousness. Therefore, it is necessary to respect the ancient saying of "preserving body fluid and protecting stomach qi", and use moderate bitter and cold medicines to dispel pathogens without harming the righteousness. In terms of potential prescriptions and medications, based on the experience of Wang Mengying in the Qing Dynasty that "emergencies and severe illnesses cannot be saved without large doses", the prescriptions with strong flavors and large doses can directly defeat the evil trend and save the dangerous syndrome at the moment. The pathogenesis of HFRS anuria in traditional Chinese medicine is similar to the modern viewpoint of western medicine. The core of treatment of ARF is how to promote the early repair of damaged glomeruli and renal tubular epithelial cells and the regeneration of necrotic cells. ARF caused by HFRS is mainly caused by heat-toxin stagnation and stagnation of the kidney, and difficulty in urination is the crux of the evil. Clinical studies have shown that the traditional Chinese medicine composition used for treating acute renal failure has the functions of clearing away heat, detoxifying, purging turbidity and saving kidney, dispelling qi and clearing accumulation, cooling blood to stop bleeding, promoting body fluid and dredging collaterals, increasing fluid and conquering the disease. For those with flaming heat and toxins and persistent high fever, follow the experience of Zhang Xichun in the Qing Dynasty to re-use gypsum, take its characteristics of clearing away heat without harming the body, and each dose can be up to 500g. Dandelion, honeysuckle, forsythia, scutellaria chinensis, and scutellaria baicalensis clear away heat, detoxify and eliminate pathogenic factors, Scrophulariae scrophulariae, Shengdi, Anemarrhena anemarrhenae clear away heat, generate body fluid and increase its liquid, and use ribs as the source of qi. The degeneration and necrosis of glomerulus and renal tubules belong to the syndrome of blood stasis in traditional Chinese medicine, so salvia miltiorrhiza, red peony root, and Chuanxiong are used to clear heat and cool blood, activate blood circulation, and dredge collaterals. The purpose of functional recovery. Drugs for promoting blood circulation and removing blood stasis can inhibit or reduce allergic damage, reduce glomerular capillary permeability, dilate renal blood vessels, increase renal blood flow, and promote the reversal of disused nephrons. Salvia miltiorrhiza is an oxygen free radical scavenger. ARF has a certain relationship with oxygen free radicals. Salvia miltiorrhiza can also regulate immunity, improve microcirculation, promote fibrin degradation, prevent cell inflammation, and resist lipid peroxidation. It can prevent or block In the formation of disseminated intravascular coagulation (DIC), traditional Chinese medicines such as Danshen Chuanxiong and other traditional Chinese medicines for promoting blood circulation and removing blood stasis have a good preventive effect on acute renal failure in the initial stage of the experiment. Therefore, the combination of the traditional Chinese medicine composition used for the treatment of acute renal failure of the present invention not only flexibly utilizes the program of dialectical treatment of traditional Chinese medicine, but also is an organic unity of combining dialectical syndrome and disease differentiation. The reason why the medicine of the present invention has a positive therapeutic effect on acute renal failure is that it has antibacterial, antiviral, prevention and treatment of immune kidney damage, improves microcirculation, increases renal blood flow, and promotes the absorption of renal blood stasis and renal tubular epithelial damage. cells, early repair and regeneration of necrotic cells. The pre- and post-observation results of ALT and AST confirmed such effects.

Typical cases:

1. Li He, male, 46 years old, from Liuzhuang Town, Queshan County, Zhumadian City, Henan Province, was admitted to our hospital on November 12, 1999 with the main complaint of "fever for 5 days and no urine for 2 days". On November 7, 1999, he developed fever, headache, lumbago, inability to eat, nausea, vomiting, abdominal distension, and lack of energy. His body temperature was 39-41°C, accompanied by intermittent chills, obvious oliguria, palpitations, and palpitation. He thought he was suffering from a cold at first. , I was given intramuscular injections of antipyretics and oral cold tablets in the village clinic. After two days, my condition did not improve, and I was still treated as a cold in the Liuzhuang Town Health Center. On the 5th day of the onset, he suddenly had hematuria, hemoptysis, persistent high fever, delirium, and anuria for 2 days. Facial flushing, hemorrhage in subpalpebral conjunctiva and bulbar conjunctiva, bulbar conjunctival edema showing obvious fish bubbles, skin bleeding spots all over the body, massive subcutaneous hemorrhage at the intramuscular injection site of both buttocks, white blood cells 13×10 ⁹ /L, platelet count 70×10 ⁹ /L, urine occult blood++++, urine protein++++, blood biochemistry: BUN665μmol/L, Cr485μmol/L, initial diagnosis: epidemic hemorrhagic fever, hypotension (shock), oliguria overlapping, Acute renal failure, critical type; TCM syndrome differentiation: Qi and Ying two burnt type (Ⅱ type). Immediately give comprehensive treatments such as anti-shock, anti-renal failure, and hemostasis. The blood pressure is stable on the first day after admission, but the urine output is less than 100ml in 24 hours. On the second day after admission, the drug decoction of the present invention is given on the basis of comprehensive treatment. , the raw material drug of the medicinal decoction of the present invention consists of: raw gypsum 150g, Anemarrhena 25g, Shengdi 30g, honeysuckle 20g, Achyranthes bidentata 10g, Shengzizi 18g, Salvia miltiorrhiza 18g, Curcuma 15g, Rhizoma Chuanxiong 18g, Radix Paeoniae Rubra 10g, paeonol 12g, Adenophora 15g, Dendrobium 12g, Rhubarb 18g and Ophiopogon japonicus 12g, take 250ml decoction for the first time for about 2 hours. Two decoctions of 200ml, and another 2 hours later, the patient urinated about 450ml, with 2 large pieces and many small fragments of membranous matter in the urine, 300g of gray-brown stool, the urine output of the day was 570ml, the body temperature dropped to 36.5°C, and the consciousness turned clear. White blood cells 11×10 ⁹ /L, platelet count 90×10 ⁹ /L, urine occult blood +++, urine protein +++, BUN365μmol/L, Cr185μmol/L. Take 5 doses continuously for 3 days as above, the urine output is 1500ml on the 3rd day of admission, 2650ml on the 4th day of admission, and the stool turns yellow. , 25g of habitat, 18g of honeysuckle, 10g of Achyranthes bidentata, 15g of Scutellaria miltiorrhiza, 18g of salvia miltiorrhiza, 18g of chuanxiong, 10g of red peony root, 12g of paeonol, 15g of sand ginseng, 10g of dendrobium and 12g of Radix Ophiopogon japonicus. The patient's urine output gradually increased to 7800 ml / Day, appetite was normal; then the raw material composition of its medicine was adjusted to: raw gypsum 25g, Anemarrhena 15g, Shengdi 15g, honeysuckle 12g, Achyranthes bidentata 10g, salvia miltiorrhiza 15g, Chuanxiong 18g, red peony root 10g, paeonol 12g, dendrobium 10g and barley Winter 12g, on the 18th day of hospitalization, urine output 3500ml/day, white blood cells 9.0×10 ⁹ /L, platelet count 120×10 ⁹ /L, urine occult blood-, urine protein+, BUN15μmol/L, Cr9μmol/L, vital signs Normal discharge. After 3 months of follow-up, the vital signs were normal, the urine output was about 3000/day, and he could work in the fields.

2. Xu Yuexing, male, 43 years old, from Puhuisi Township, Queshan County, Zhumadian City, Henan Province, was admitted to our hospital on December 9, 2004 with the main complaint of "fever for 5 days, coma for 3 days, and anuria for 2 days". . On December 3, 2004, he developed fever, severe headache with low back pain, unable to eat, nausea, vomiting, abdominal distension, delirium and mania, body temperature at 39.5-41.5°C, yellow urine and oliguria. Initially, he was given intramuscular injection of antipyretic drugs in the village clinic , took cold medicines orally, but his condition did not improve. He went to Queshan County People’s Hospital for treatment. On the 3rd day of the onset, he was confused, high fever persisted, delirium, and had no urine for 2 days. /min, R25/min, BP70/40mmHg, confusion, delirium mania, facial flushing, hemorrhage in the conjunctiva and bulbar conjunctiva, high degree of edema of the bulbar conjunctiva, dense skin bleeding spots all over the body, large area of subcutaneous hemorrhage at the intramuscular injection site of both buttocks, White blood cells 13.5×10 ⁹ /L, platelet count 69×10 ⁹ /L, urine occult blood++++, urine protein++++, blood biochemistry: BUN636μmol/L, Cr493μmol/L, preliminary diagnosis: epidemic hemorrhagic fever , Hypotension (shock), overlap of oliguria, acute renal failure, critical illness; TCM syndrome differentiation: flaming toxic heat, dynamic blood closure type (Type Ⅲ). Immediately given comprehensive treatment such as anti-shock and anti-renal failure. On the first day after admission, the blood pressure was stable, and the urine output was 80ml/day, which contained debris-like gray-white membranes. On the second day after admission, he was given comprehensive treatment. The Chinese medicine composition of the present invention is treated, and the crude drug of the Chinese medicine composition decoction of the present invention consists of raw gypsum 120g, Zhimu 25g, Shengdi 25g, honeysuckle 20g, Achyranthes bidentata 12g, Shengzizi 18g, Salvia miltiorrhiza 18g, Curcuma 15g, Ligusticum chuanxiong 18g, 10g of Radix Paeoniae Rubra, 25g of Patrinia, 12g of Bletilla striata, 15g of each thistle, 20g of buffalo horn and 1.5g of Angong Niuhuang Wan (mixed with water), take the first decoction of 250ml for about 2.5 hours, and the patient's bowel sounds rumbling , 450g of dark red mixed tarry stools, and 2 hours of serving the second decoction 200ml, after another 3 hours, the patient urinates about 250ml, there are 4 large pieces and many small fragments of membranous matter in the urine, gray-brown stool 400g, urine output 450ml that day, body temperature dropped to 37.5°C, consciousness turned clear, white blood cells 12.5×10 ⁹ /L, platelet count 75×10 ⁹ /L, urine occult blood +++, urine protein +++, BUN385μmol/L , Cr175μmol/L, Shoufang took 6 doses for 3 days, 1200ml on the 3rd day of admission, 2550ml of urine on the 4th day of admission, and the stool turned yellow. 20g, raw land 25g, honeysuckle 18g, Achyranthes bidentata 12g, raw mast 15g, salvia miltiorrhiza 18g, turmeric 15g, chuanxiong 18g, red peony root 10g, Patrinia 18g, bletilla striata 10g, large and small thistle 10g, buffalo horn 15g and Angong Niuhuang Wan 1.5g (washed), the urine output of the patient gradually increased to 8600/day, and the appetite was normal; then the raw material composition of the drug formula was adjusted to: 25g of raw gypsum, 15g of Anemarrhena, 18g of Shengdi, 12g of honeysuckle, 10g of Achyranthes bidentata, raw Gardenia 12g, Salvia 12g, Curcuma 12g, Chuanxiong 18g and Chishao 10g, on the 20th day of hospitalization, urine output 3200ml/day, white blood cells 8.5×10 ⁹ /L, platelet count 110×10 ⁹ /L, urine occult blood- , urine protein+, BUN12μmol/L, Cr10μmol/L, and the vital signs were normal and discharged. After 3 months of follow-up, the vital signs were normal, the urine output was about 3200/day, and there was no obvious abnormality.

3. Huang Yong, male, 18 years old, from Sanlihe Township, Queshan County, Zhumadian City, Henan Province, was admitted to our hospital on October 19, 2002 with the main complaint of "fever for 6 days and no urine for 2 days". On October 13, 2002, he developed fever, severe headache with low back pain, unable to eat, nausea, vomiting, abdominal distension, continuous coughing, yellow sticky tongue, delirium and mania, body temperature at 39-40.5°C, yellow urine and oliguria. Intramuscular injection of aminopyrine and oral administration of aspirin tablets were given in the room. His condition did not improve, and he went to Queshan County People's Hospital for treatment. On the 4th day of the onset, he began to lose consciousness, high fever, delirium, and anuria for 2 days. Seeing a doctor in our hospital, physical examination T41.6 ℃, P128/min, R28/min, BP74/42mmHg, confusion, delirium mania, facial flushing, hemorrhage under the conjunctiva and bulbar conjunctiva, high degree of edema of the bulbar conjunctiva, red tongue, moss Thick and dry yellow, thready and rapid pulse, dense skin bleeding spots all over the body, massive subcutaneous hemorrhage at the intramuscular injection site of both buttocks, white blood cells 12.5×10 ⁹ /L, platelet count 62×10 ⁹ /L, urine occult blood++++, urine protein ++++, blood biochemistry: BUN596μmol/L, Cr468μmol/L, preliminary diagnosis: epidemic hemorrhagic fever, hypotension (shock), overlapping oliguria, acute renal failure, critical type; TCM syndrome differentiation: lung and stomach heat (Type I). Immediately given comprehensive treatment such as anti-shock and anti-renal failure, blood pressure was stable on the first day after admission, urine output was 85ml/day, and contained 2 tablets of gray-white membranous matter, and on the second day after admission, this patient was given comprehensive treatment. Invented Chinese medicine composition decoction for treatment, the raw materials of the Chinese medicine composition are composed of raw gypsum 150g, Anemarrhena 25g, Shengdi 30g, honeysuckle 25g, Achyranthes bidentata 10g, Shengzizi 18g, Salvia miltiorrhiza 18g, Curcuma 12g, Chuanxiong 18g , Radix Paeoniae Rubra 10g, Platycodon grandiflorum 12g, Baiqian 15g, Chuanbei 15g, Tinglizi 10g and almond 9g, take the first decoction 250ml for about 1.5 hours. Stool 250g, and take the second decoction 250ml for another 3 hours. After another 2 hours, the patient urinates about 550ml. There are 3 large pieces of grayish white with dark red and many small pieces of membrane in the urine. The tarry stool is 400g. The urine volume of the day 350ml, body temperature dropped to 37.2°C, consciousness turned clear, white blood cells 12.5×10 ⁹ /L, platelet count 75×10 ⁹ /L, urine occult blood +++, urine protein +++, BUN385μmol/L, Cr175μmol/L, Shoufang took 6 doses for 4 days, the urine output was 1500ml on the 3rd day of admission, 2700ml on the 4th day of admission, and the stool turned from black to yellow. On the 5th day of admission, the composition of raw materials of the Chinese medicine composition was adjusted to 30g of raw gypsum, 18g of Anemarrhena, 25g of Shengdi, 18g of honeysuckle, 10g of Achyranthes bidentata, 15g of Shengzizi, 18g of salvia miltiorrhiza, 18g of Chuanxiong, 10g of red peony root, 12g of bellflower, Baiqian 12g, Chuanbei 10g, Tinglizi 9g and almond 6g; cough and sputum basically disappeared, the tongue coating turned thin and slightly yellow, the patient's urine output gradually increased to 8600 ml/day, and the appetite was normal; then the raw materials of the Chinese medicine composition The medicinal composition was adjusted to 25g of raw gypsum, 12g of Zhimu, 18g of Shengdi, 12g of honeysuckle, 10g of Achyranthes bidentata, 12g of salvia miltiorrhiza, 12g of turmeric, 18g of Chuanxiong and 10g of red peony. On the 20th day of hospitalization, the urine output was 3200ml/day, the white blood cell count was 9.5×10 ⁹ /L, the platelet count was 115×10 ⁹ /L, urine occult blood-, urine protein+, BUN10μmol/L, Cr8μmol/L, and the vital signs were normal and discharged. After 3 months of follow-up, the vital signs were normal, the urine output was about 3200 ml/day, and he felt good about himself.

4. Niu Erzhu, male, 43 years old, from the east team of Niuwan Village, Liudian Town, Queshan County, Zhumadian City, Henan Province. On December 3, 2001, he complained of "fever for 5 days, coma for 2 days, and anuria for 1 day". Take me to the hospital. On November 28, 2001, he developed fever, headache, orbital pain, pain in the kidney area, unable to eat, nausea, vomiting, abdominal distension, delirium and mania, body temperature above 39-40°C, and little yellow urine. I bought oral tablets of cold medicine at the beginning, but my condition did not improve. I went to Queshan County People's Hospital for treatment. On the 4th day of the onset, I was confused, high fever persisted, delirium, and anuria for 1 day. I rushed to our hospital for treatment. Physical examination T41.2 ℃, P128/min, R26/min, BP70/40mmHg, confusion, mania, flushing, bleeding in the conjunctiva and bulbar conjunctiva, high degree of edema of the bulbar conjunctiva, dense skin bleeding spots all over the body, both buttocks Extensive subcutaneous hemorrhage at the intramuscular injection site, blood leukocytes 11.5×10 ⁹ /L, platelet count 58×10 ⁹ /L, urine occult blood++++, urine protein++++, blood biochemistry: BUN623μmol/L, Cr593μmol/L , Preliminary diagnosis: epidemic hemorrhagic fever, hypotension (shock), overlapping oliguria, acute renal failure, critical illness; TCM syndrome differentiation: flaming toxic heat, dynamic blood closure type (Type III). Immediately given comprehensive treatment such as anti-shock and anti-renal failure. On the first day after admission, the blood pressure was stable, and the urine output was 85ml/day, which contained a large amount of debris-like gray-white membrane. On the second day after admission, he was given comprehensive treatment. Treat in the Chinese medicine composition decoction of the present invention, and the crude drug of Chinese medicine composition is composed of raw gypsum 150g, Anemarrhena 25g, Radix Rehmanniae 30g, Flos Lonicerae 25g, Achyranthes bidentata 12g, Fructus Sinensis 18g, Salvia miltiorrhiza 18g, Curcuma 15g, Rhizoma Chuanxiong 18g, Radix Paeoniae Rubra 10g, Patrinia 25g, Bletilla striata 12g, thistle 15g each, buffalo horn 20g and Angong Niuhuang Wan 1.5g (mixed with water); take the first decoction 250ml for about 3 hours, and the patient's bowel sounds rumbling , 450g dark red mixed tarry stool, and 2.5 hours to take the second decoction 250ml, after another 2 hours, the patient urinates about 450ml, there are 2 large pieces and many small fragments of membranous matter in the urine, grayish brown stool 430g, urine output 550ml that day, body temperature dropped to 36.5°C, consciousness turned clear, white blood cells 11.5×10 ⁹ /L, platelet count 65×10 ⁹ /L, urine occult blood +++, urine protein +++, BUN365μmol/L , Cr155μmol/L. Shoufang took 4 doses for 3 days, 1500ml on the 3rd day of admission, 2750ml of urine on the 4th day of admission, and the stool turned yellow. On the 5th day of admission, the prescription was adjusted to 25g of raw gypsum, 15g of Anemarrhena, 15g of Shengdi, 10g of honeysuckle, 10g of Achyranthes bidentata, 12g of Shengzizi, 18g of salvia miltiorrhiza, 12g of turmeric, 18g of Chuanxiong, 10g of red peony, 18g of Patrinia, Bletilla striata 10g, large and small thistles 10g each, buffalo horn 12g and amber powder 1.5g (taken after mixing). The patient's urine output gradually increased to 7900 ml/day, and his appetite was normal; then the drug formula was adjusted as follows: gypsum 30g, Anemarrhena 15g, Shengdi 12g, honeysuckle 10g, Achyranthes bidentata 10g, Salvia miltiorrhiza 12g, Yujin 10g, Ligusticum chuanxiong 18g and Radix Paeoniae Rubra 10g, on the 19th day of hospitalization, urine output 3000ml/day, white blood cells 9.5×10 ⁹ /L, platelet count 120×10 ⁹ /L, urine occult blood-, urine protein+, BUN12.5μmol/L, Cr9.5μmol /L, the vital signs were normal and discharged. After 3 months of follow-up, the vital signs were normal, the urine output was about 3500/day, and the life was normal.

5. Li Dachang, male, 23 years old, from Rendian Town, Queshan County, Zhumadian City, Henan Province, was admitted to our hospital on December 7, 2010 with the main complaint of "fever for 6 days and no urine for 2 days". On December 1, 2010, he developed fever, headache, orbital pain, low back pain, nausea, vomiting, abdominal distension, delirium and mania, body temperature above 40°C, and less yellow urine. He took cold medicine at the local clinic, but his condition did not improve. He went to the local county People's Hospital treatment, on the 4th day of the onset, confusion, persistent high fever, delirium, anuria for 2 days, rushed to our hospital for treatment, physical examination T41.6 ℃, P126/min, R24/min, BP70/40mmHg, consciousness Unclear, restless mania, flushing of the face, hemorrhage under the conjunctiva and bulbar conjunctiva, high degree of edema of the bulbar conjunctiva, dense skin bleeding spots all over the body, large area of subcutaneous hemorrhage at the intramuscular injection site of both buttocks, blood white blood cells 13.5×10 ⁹ /L, platelet count 59 ×10 ⁹ /L, urine occult blood++++, urine protein++++, blood biochemistry: BUN662μmol/L, Cr591μmol/L, preliminary diagnosis: epidemic hemorrhagic fever, hypotension (shock), oliguric overlap, acute Renal failure, critical type; TCM syndrome differentiation: flaming toxic heat, hemorrhagic closure type (Type III). Comprehensive treatment such as anti-shock and anti-renal failure was given immediately. On the first day after admission, the blood pressure was stable, and the urine output was 95ml/day, which contained a large amount of debris-like gray-white membrane. On the second day after admission, he was given comprehensive treatment. Treat in the Chinese medicine composition decoction of the present invention, and its drug composition is raw gypsum 130g, Anemarrhena 25g, Shengdi 25g, honeysuckle 20g, Achyranthes bidentata 12g, Shengzizi 18g, Salvia miltiorrhiza 18g, Curcuma 12g, Rhizoma Chuanxiong 18g, Radix Paeoniae Rubra 10g , Patrinia 25g, Bletilla striata 12g, thistle 12g each, buffalo horn 20g and Angong Niuhuang Wan 1.5g; take the first decoction 250ml for about 2.5 hours, the patient's bowel sounds rumbled, less dark red mixed with asphalt 250g of sample stool, and 250ml of decoction for another 3 hours. After 1.5 hours, the patient urinates about 350ml. There are 5 large pieces and many small pieces of membranous matter in the urine. Dropped to 38.5 ℃, consciousness cleared, blood pressure 105/65mmHg, white blood cells 10.5×10 ⁹ /L, platelet count 75×10 ⁹ /L, urine occult blood +++, urine protein +++, BUN305μmol/L, Cr135μmol/L L. Shoufang took 4 doses for 2 days, 1500ml on the 3rd day of admission, 2450ml of urine on the 4th day of admission, and the stool turned yellow. On the 5th day of admission, the prescription was adjusted to 100g of raw gypsum, 20g of Anemarrhena, 15g of raw land, 12g of honeysuckle, 10g of Achyranthes bidentata, 12g of shengmengzi, 18g of salvia miltiorrhiza, 18g of Chuanxiong, 10g of red peony root, 10g of ginseng, 12g of Ophiopogon japonicus and 18g of Schisandra chinensis. The patient's urine output gradually increased to 7900/day, and his appetite was normal. Then his drug formula was adjusted to gypsum 25g, Anemarrhena 15g, Shengdi 12g, honeysuckle 10g, salvia miltiorrhiza 12g, turmeric 15g, chuanxiong 18g and red peony root 10g. On the 19th day of hospitalization, urine output was 3000ml/day, white blood cell count was 8.5×10 ⁹ /L, platelet count was 125×10 ⁹ /L, urine occult blood-, urine protein+, BUN10.5μmol/L, Cr8.5μmol/L, life His symptoms were normal and he was discharged. After 3 months of follow-up, the vital signs were normal, the urine output was about 3100/day, and the life was normal.

Detailed ways:

The present invention is further set forth below in conjunction with embodiment, but content of the present invention is not limited.

Example 1:

The present invention is used for the treatment of the traditional Chinese medicine composition of acute renal failure, expressed in parts by weight, the crude drug of the Chinese medicinal composition is composed of raw gypsum 50g, Zhimu 15g, Shengdi 25g, honeysuckle 15g, Achyranthes bidentata 11g, Shengzizi 16g, Composed of 12g of Danshen, 12g of Curcuma, 15g of Chuanxiong and 12g of Radix Paeoniae Rubra.

Example 2:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 25g of Gypsum, 12g of Anemarrhena, 18g of Radix Rehmannia, 10g of Honeysuckle, 10g of Achyranthes bidentata, 18g of Raw Fructus Rhizome, Composed of 10g of Danshen, 13g of Curcuma, 12g of Chuanxiong and 15g of Radix Paeoniae Rubra.

Example 3:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 80g of gypsum, 20g of Anemarrhena, 15g of Rehmannia glutinosa, 12g of honeysuckle, 12g of Achyranthes bidentata, 12g of Shengzizi, Composed of 15g of Danshen, 10g of Curcuma, 13g of Chuanxiong and 10g of Radix Paeoniae Rubra.

Example 4:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are composed of raw gypsum 100g, Zhimu 18g, Shengdi 20g, honeysuckle 18g, Achyranthes bidentata 10g, Shengzizi 13g, Composed of 18g of Danshen, 15g of Curcuma, 12g of Chuanxiong and 10g of Radix Paeoniae Rubra.

Example 5:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are composed of raw gypsum 120g, Zhimu 12g, Shengdi 16g, honeysuckle 16g, Achyranthes bidentata 11g, Shengzizi 14g, Composed of 13g of Danshen, 10g of Curcuma, 18g of Chuanxiong and 13g of Radix Paeoniae Rubra.

Embodiment 6:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the traditional Chinese medicine composition are 150 g of raw gypsum, 13 g of Anemarrhena, 22 g of Rehmannia, 20 g of honeysuckle, 12 g of Achyranthes bidentata, 12 g of Scutellaria chinensis, Composed of 10g of Danshen, 10g of Curcuma, 12g of Chuanxiong and 14g of Radix Paeoniae Rubra.

Embodiment 7:

The present invention is used for the treatment of the traditional Chinese medicine composition of acute renal failure, expressed in parts by weight, the crude drug of the Chinese medicinal composition is composed of raw gypsum 35g, Zhimu 25g, Shengdi 26g, honeysuckle 25g, Achyranthes bidentata 10g, Shengzizi 15g, Composed of 15g of Danshen, 12g of Curcuma, 15g of Chuanxiong and 10g of Radix Paeoniae Rubra.

Embodiment 8:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 70g of gypsum, 21g of Anemarrhena, 30g of Radix Rehmannia, 16g of honeysuckle, 10g of Achyranthes bidentata, 12g of Shengzizi, Composed of 14g of Danshen, 15g of Curcuma, 12g of Chuanxiong and 10g of Radix Paeoniae Rubra.

Embodiment 9:

The present invention is used for the treatment of the traditional Chinese medicine composition of acute renal failure, expressed in parts by weight, the crude drug of the Chinese medicinal composition is composed of raw gypsum 50g, Zhimu 15g, Shengdi 25g, honeysuckle 15g, Achyranthes bidentata 11g, Shengzizi 16g, Salvia miltiorrhiza 12g, turmeric 12g, Chuanxiong 15g, red peony root 12g, bellflower 12g, white front 11g, Chuanbei 13g, Tinglizi 11g and almond 8g.

Example 10:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 25g of Gypsum, 12g of Anemarrhena, 18g of Radix Rehmannia, 10g of Honeysuckle, 10g of Achyranthes bidentata, 18g of Raw Fructus Rhizome, Salvia miltiorrhiza 10g, turmeric 13g, Chuanxiong 12g, red peony 15g, bellflower 10g, white front 10g, Chuanbei 10g, Tinglizi 10g and almond 6g.

Example 11:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 80g of gypsum, 20g of Anemarrhena, 15g of Rehmannia glutinosa, 12g of honeysuckle, 12g of Achyranthes bidentata, 12g of Shengzizi, Salvia miltiorrhiza 15g, turmeric 10g, Chuanxiong 13g, red peony 10g, bellflower 14g, white front 12g, Chuanbei 12g, Tinglizi 12g and almond 10g.

Example 12:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are composed of raw gypsum 100g, Zhimu 18g, Shengdi 20g, honeysuckle 18g, Achyranthes bidentata 10g, Shengzizi 13g, Salvia miltiorrhiza 18g, turmeric 15g, Chuanxiong 12g, red peony root 10g, bellflower 11g, white front 13g, Chuanbei 15g, Tinglizi 10g and almond 7g.

Example 13:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are composed of raw gypsum 120g, Zhimu 12g, Shengdi 16g, honeysuckle 16g, Achyranthes bidentata 11g, Shengzizi 14g, Salvia miltiorrhiza 13g, turmeric 10g, Chuanxiong 18g, red peony 13g, bellflower 15g, white front 15g, Chuanbei 15g, Tinglizi 12g and almond 10g.

Example 14:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the traditional Chinese medicine composition are 150 g of raw gypsum, 13 g of Anemarrhena, 22 g of Rehmannia, 20 g of honeysuckle, 12 g of Achyranthes bidentata, 12 g of Scutellaria chinensis, Salvia miltiorrhiza 10g, turmeric 10g, Chuanxiong 12g, red peony root 14g, bellflower 13g, white front 12g, Chuanbei 12g, Tinglizi 10g and almond 6g.

Example 15:

The present invention is used for the treatment of the traditional Chinese medicine composition of acute renal failure, expressed in parts by weight, the crude drug of the Chinese medicinal composition is composed of raw gypsum 35g, Zhimu 25g, Shengdi 26g, honeysuckle 25g, Achyranthes bidentata 10g, Shengzizi 15g, Salvia miltiorrhiza 15g, turmeric 12g, Chuanxiong 15g, red peony root 10g, bellflower 10g, white front 11g, Chuanbei 13g, Tinglizi 10g and almond 6g.

Example 16:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 70g of gypsum, 21g of Anemarrhena, 30g of Radix Rehmannia, 16g of honeysuckle, 10g of Achyranthes bidentata, 12g of Shengzizi, Salvia miltiorrhiza 14g, turmeric 15g, Chuanxiong 12g, red peony root 10g, bellflower 12g, white front 10g, Chuanbei 12g, Tinglizi 10g and almond 7g.

Example 17:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 35g of Gypsum, 22g of Anemarrhena, 23g of Radix Rehmannia, 15g of Flos Lonicerae, 10g of Achyranthes bidentata, 14g of Fructus Sinensis, Composed of 14g of Salvia miltiorrhiza, 10g of turmeric, 18g of Chuanxiong, 13g of red peony, 13g of Zhuru and 6g of ochre.

Example 18:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 25g of Gypsum, 12g of Anemarrhena, 15g of Radix Rehmannia, 12g of Honeysuckle, 9g of Achyranthes bidentata, 10g of Raw Fructus Rhizome, Salvia miltiorrhiza 10g, turmeric 8g, Chuanxiong 12g, red peony root 10g, Zhuru 10g and ochre 6g.

Example 19:

The present invention is used for the treatment of the traditional Chinese medicine composition of acute renal failure, expressed in parts by weight, the crude drug of the Chinese medicinal composition is composed of raw gypsum 50g, Anemarrhena 25g, Rehmannia glutinosa 30g, honeysuckle 20g, Achyranthes bidentata 12g, Shengzizi 18g, Salvia miltiorrhiza 18g, turmeric 15g, Chuanxiong 25g, red peony root 15g, Zhuru 15g and ochre 9g.

Example 20:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 30 g of raw gypsum, 16 g of Anemarrhena, 20 g of Rehmannia Radix, 18 g of honeysuckle, 11 g of Achyranthes bidentata, 16 g of Shengzizi, Composed of 12g of Salvia miltiorrhiza, 13g of turmeric, 22g of Chuanxiong, 12g of red peony, 12g of Zhuru and 7g of ochre.

Example 21:

The traditional Chinese medicine composition used for the treatment of acute renal failure of the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 40g of Gypsum, 14g of Anemarrhena, 26g of Radix Rehmanniae, 13g of Honeysuckle, 10g of Achyranthes bidentata, 12g of Raw Fructus Rhizome, Salvia miltiorrhiza 16g, turmeric 12g, Chuanxiong 20g, red peony root 10g, Zhuru 12g and ochre 8g.

Example 22:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 45g of Gypsum, 15g of Anemarrhena, 18g of Radix Rehmannia, 16g of Flos Lonicerae, 10g of Achyranthes bidentata, 15g of Fructus Sinensis, Salvia miltiorrhiza 12g, turmeric 9g, Chuanxiong 16g, red peony root 13g, Zhuru 11g and ochre 7g.

Example 23:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 35g of Gypsum, 22g of Anemarrhena, 23g of Radix Rehmanniae, 15g of Honeysuckle, 11g of Achyranthes bidentata, 14g of Shengzizi, Composition of 14g of Salvia miltiorrhiza, 12g of turmeric, 18g of Chuanxiong, 13g of red peony, 18g of schisandra and 14g of heterophylla.

Example 24:

The present invention is used for the treatment of acute renal failure Chinese medicine composition, expressed in parts by weight, the crude drug of the Chinese medicine composition consists of raw gypsum 25g, Anemarrhena 12g, Shengdi 12g, honeysuckle 10g, Achyranthes bidentata 9g, Shengzizi 10g, Consists of 10g of Salvia miltiorrhiza, 10g of turmeric, 12g of Chuanxiong, 10g of red peony, 12g of schisandra and 12g of heterophylla.

Example 25:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 50g of Gypsum, 25g of Anemarrhena, 30g of Radix Rehmannia, 25g of Honeysuckle, 15g of Achyranthes bidentata, 18g of Raw Fructus Rhizome, Composition of 20g of Salvia miltiorrhiza, 15g of turmeric, 25g of Chuanxiong, 18g of red peony, 25g of schisandra and 18g of heterophylla.

Example 26:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 30 g of gypsum, 16 g of Anemarrhena, 20 g of Rehmannia Radix, 20 g of honeysuckle, 13 g of Achyranthes bidentata, 16 g of Shengzizi, Composition of 12g of Salvia miltiorrhiza, 13g of turmeric, 22g of Chuanxiong, 15g of red peony, 22g of schisandra and 16g of heterophylla.

Example 27:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 40g of Gypsum, 14g of Anemarrhena, 26g of Radix Gypsum, 12g of Honeysuckle, 10g of Achyranthes bidentata, 12g of Raw Fructus Rhizome, Composed of 16g of Salvia miltiorrhiza, 12g of turmeric, 20g of Chuanxiong, 12g of red peony, 20g of schisandra and 13g of heterophylla.

Example 28:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the traditional Chinese medicine composition are 45g of Gypsum, 15g of Anemarrhena, 18g of Radix Rehmannia, 22g of Honeysuckle, 12g of Achyranthes bidentata, 15g of Raw Fructus Rhizome, Composed of 12g of Salvia miltiorrhiza, 9g of turmeric, 16g of Chuanxiong, 14g of red peony, 16g of schisandra and 15g of heterophylla.

Example 29:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 50 g of raw gypsum, 15 g of Zhimu, 25 g of Rehmannia Radix, 16 g of honeysuckle, 10 g of Achyranthes bidentata, 16 g of Shengzizi, 13g of Danshen, 12g of Curcuma, 15g of Rhizoma Chuanxiong, 12g of Radix Paeoniae Rubra, 12g of Danshen, 11g of Radix Ginseng, 10g of Dendrobium, 15g of Rhubarb and 13g of Ophiopogon japonicus.

Example 30:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 25g of Gypsum, 12g of Anemarrhena, 18g of Radix Rehmannia, 12g of Honeysuckle, 9g of Achyranthes bidentata, 18g of Shengzizi, Composition of Danshen 10g, Curcuma 13g, Chuanxiong 12g, Radix Paeoniae Rubra 15g, Paeonolium 10g, Radix Radix 10g, Dendrobium 9g, Rhubarb 10g and Ophiopogon japonicus 10g.

Example 31:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 80g of Gypsum, 20g of Anemarrhena, 12g of Radix Rehmannia, 14g of Honeysuckle, 12g of Achyranthes bidentata, 12g of Raw Fructus Rhizome, Salvia miltiorrhiza 16g, turmeric 9g, Chuanxiong 13g, red peony 10g, paeonol 14g, sand ginseng 12g, dendrobium 12g, rhubarb 13g and Ophiopogon japonicus 12g.

Example 32:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are composed of raw gypsum 100g, Zhimu 18g, Shengdi 20g, honeysuckle 20g, Achyranthes bidentata 11g, Shengzizi 13g, 20g of Danshen, 15g of Curcuma, 16g of Rhizoma Chuanxiong, 10g of Radix Paeoniae Rubra, 11g of Paeonolium Cortex, 13g of Radix Radix, 15g of Dendrobium, 25g of Rhubarb and 15g of Ophiopogon japonicus.

Example 33:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 120 g of Gypsum, 12 g of Anemarrhena, 16 g of Rehmannia Radix, 18 g of Honeysuckle, 10 g of Achyranthes bidentata, 14 g of Fructus Achyranthes, Salvia miltiorrhiza 14g, turmeric 10g, Chuanxiong 25g, red peony root 13g, paeonol 15g, sand ginseng 15g, dendrobium 15g, rhubarb 30g and Ophiopogon japonicus 14g.

Example 34:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 150g of gypsum, 13g of Zhimu, 22g of Rehmannia, 22g of honeysuckle, 12g of Achyranthes bidentata, 12g of Shengzizi, Composed of 10g of Danshen, 10g of Curcuma, 14g of Rhizoma Chuanxiong, 14g of Radix Paeoniae Rubra, 13g of Paeonolium Cortex, 12g of Radix Radix, 12g of Dendrobium, 18g of Rhubarb and 12g of Ophiopogon japonicus.

Example 35:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 35g of gypsum, 25g of Zhimu, 26g of Shengdi, 23g of honeysuckle, 10g of Achyranthes bidentata, 15g of Shengzizi, Composition of 15g of Danshen, 12g of Curcuma, 18g of Chuanxiong, 10g of Radix Paeoniae Rubra, 10g of Danpi, 10g of Radix Radix, 11g of Dendrobium, 22g of Rhubarb and 10g of Ophiopogon japonicus.

Example 36:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 70g of gypsum, 21g of Anemarrhena, 30g of Radix Rehmannia, 16g of honeysuckle, 10g of Achyranthes bidentata, 12g of Shengzizi, Composition of 14g of Danshen, 15g of Curcuma, 12g of Chuanxiong, 10g of Radix Paeoniae Rubra, 12g of Paeonolium, 10g of Radix Radix, 10g of Dendrobium, 26g of Rhubarb and 12g of Ophiopogon japonicus.

Example 37:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 50g of Gypsum, 16g of Anemarrhena, 25g of Radix Rehmanniae, 15g of Honeysuckle, 12g of Achyranthes bidentata, 12g of Shengzizi, Composition of 16g of Salvia miltiorrhiza, 11g of turmeric, 15g of Chuanxiong, 12g of red peony, 9g of Uncaria and 10g of Shichangpu.

Example 38:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 25g of Gypsum, 12g of Anemarrhena, 18g of Rehmannia Radix, 10g of Honeysuckle, 9g of Achyranthes bidentata, 10g of Raw Fructus Rhizome, Composed of 18g of Salvia miltiorrhiza, 13g of turmeric, 12g of Chuanxiong, 15g of red peony, 10g of Uncaria and 9g of Shichangpu.

Example 39:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 80g of Gypsum, 22g of Anemarrhena, 15g of Rehmannia Radix, 12g of Honeysuckle, 13g of Achyranthes bidentata, 15g of Raw Fructus Rhizome, Composition of 12g of Salvia miltiorrhiza, 9g of turmeric, 13g of Chuanxiong, 10g of red peony, 10g of Uncaria and 12g of Shichangpu.

Example 40:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are composed of raw gypsum 100g, Anemarrhena 20g, Rehmannia glutinosa 20g, Flos Lonicerae 18g, Achyranthes bidentata 15g, Fructus Sinensis 18g, Composed of 13g of Salvia miltiorrhiza, 15g of turmeric, 16g of Chuanxiong, 10g of red peony, 10g of Uncaria and 15g of Shichangpu.

Example 41:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are composed of gypsum 120g, Zhimu 15g, Shengdi 16g, honeysuckle 16g, Achyranthes bidentata 14g, Shengzizi 13g, Composed of 14g of Salvia miltiorrhiza, 10g of turmeric, 25g of Chuanxiong, 13g of red peony, 9g of Uncaria and 15g of Shichangpu.

Example 42:

The present invention is used for the treatment of acute renal failure Chinese medicine composition, expressed in parts by weight, the crude drug of the Chinese medicine composition is composed of raw gypsum 150g, Anemarrhena 25g, Shengdi 22g, honeysuckle 20g, Achyranthes bidentata 12g, Shengzizi 10g, Composition of 12g of Salvia miltiorrhiza, 12g of turmeric, 14g of Chuanxiong, 14g of red peony, 9g of Uncaria and 12g of Shichangpu.

Example 43:

The present invention is used for the treatment of the traditional Chinese medicine composition of acute renal failure, expressed in parts by weight, the crude drug of the Chinese medicinal composition is composed of raw gypsum 35g, Anemarrhena 30g, Shengdi 26g, honeysuckle 25g, Achyranthes bidentata 10g, Shengzizi 15g, Composed of 15g of Salvia miltiorrhiza, 13g of turmeric, 18g of Chuanxiong, 10g of red peony, 10g of Uncaria and 11g of Shichangpu.

Example 44:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 70g of Gypsum, 28g of Anemarrhena, 30g of Radix Rehmanniae, 16g of Honeysuckle, 9g of Achyranthes bidentata, 14g of Achyranthes chinensis, Composition of 12g of Salvia miltiorrhiza, 10g of turmeric, 12g of Chuanxiong, 10g of red peony, 10g of Uncaria and 10g of Shichangpu.

Example 45:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 120g of Gypsum, 16g of Anemarrhena, 15g of Radix Rehmannia, 15g of Honeysuckle, 13g of Achyranthes bidentata, 13g of Raw Fructus Rhizome, Salvia miltiorrhiza 15g, turmeric 10g, Chuanxiong 15g, red peony 12g, Patrinia 26g, Bletilla striata 10g, thistle 12g each, buffalo horn 13g and amber powder 1.5g.

Example 46:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 135g of gypsum, 18g of Zhimu, 25g of Shengdi, 22g of honeysuckle, 16g of Achyranthes bidentata, 16g of Shengzizi, Salvia 12g, Curcuma 13g, Chuanxiong 12g, Chishao 16g, Patrinia 18g, Bletilla striata 10g, thistle 10g each, buffalo horn 10g and amber powder 1.5g.

Example 47:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 50 g of Gypsum, 26 g of Anemarrhena, 18 g of Rehmannia Radix, 13 g of Flos Lonicerae, 14 g of Achyranthes bidentata, 15 g of Fructus Sinensis, Salvia 13g, Curcuma 12g, Chuanxiong 16g, Chishao 10g, Patrinia 20g, Bletilla striata 12g, thistle 13g each, buffalo horn 15g and amber powder 1.5g.

Example 48:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 100 g of gypsum, 30 g of Anemarrhena, 20 g of Rhizoma Rehmanniae, 18 g of honeysuckle, 17 g of Achyranthes bidentata, 18 g of Radix Sinensis, Salvia 18g, Curcuma 14g, Chuanxiong 18g, Chishao 15g, Patrinia 15g, Bletilla striata 11g, thistle 15g each, buffalo horn 18g and amber powder 1.5g.

Example 49:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 80 g of raw gypsum, 15 g of Anemarrhena, 16 g of raw land, 12 g of honeysuckle, 15 g of Achyranthes bidentata, 12 g of raw sage, Salvia miltiorrhiza 20g, turmeric 10g, Chuanxiong 13g, red peony 13g, Patrinia 25g, Bletilla striata 10g, thistle 10g each, buffalo horn 10g and Angongniuhuang pill 1.5g.

Example 50:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the traditional Chinese medicine composition are 30 g of raw gypsum, 20 g of Anemarrhena, 22 g of raw land, 20 g of honeysuckle, 12 g of Achyranthes bidentata, 16 g of raw sage, Salvia miltiorrhiza 16g, turmeric 9g, Chuanxiong 12g, red peony 10g, Patrinia 28g, Bletilla striata 12g, thistle 12g each, buffalo horn 16g and Angongniuhuang pill 1.5g.

Example 51:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 150 g of raw gypsum, 22 g of Zhimu, 26 g of Rehmannia glutinosa, 25 g of honeysuckle, 18 g of Achyranthes bidentata, 18 g of Shengzizi, Salvia miltiorrhiza 20g, turmeric 15g, Chuanxiong 18g, red peony 18g, Patrinia 30g, Bletilla striata 12g, thistle 15g each, buffalo horn 20g and Angongniuhuang pill 1.5g.

Example 52:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 95g of gypsum, 28g of Zhimu, 17g of Shengdi, 16g of honeysuckle, 12g of Achyranthes bidentata, 17g of Shengzizi, Salvia miltiorrhiza 15g, turmeric 12g, Chuanxiong 16g, red peony 13g, Patrinia 20g, Bletilla striata 10g, thistle 13g each, buffalo horn 18g and Angongniuhuang pill 1.5g.

Example 53:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 140g of Gypsum, 16g of Anemarrhena, 15g of Radix Rehmannia, 18g of Honeysuckle, 10g of Achyranthes bidentata, 12g of Raw Fructus Rhizome, Composed of 14g of Danshen, 10g of Curcuma, 13g of Chuanxiong, 10g of Radix Paeoniae Rubra, 12g of Ginseng, 10g of Ophiopogon japonicus and 15g of Schisandra.

Example 54:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 80 g of gypsum, 12 g of Anemarrhena, 17 g of Rehmannia glutinosa, 22 g of honeysuckle, 12 g of Achyranthes bidentata, 15 g of Shengzizi, Composed of 12g of Danshen, 12g of Curcuma, 15g of Chuanxiong, 12g of Radix Paeoniae Rubra, 13g of Ginseng, 12g of Ophiopogon japonicus and 12g of Schisandra.

Example 55:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 120 g of raw gypsum, 20 g of Anemarrhena, 26 g of Radix Rehmannia, 20 g of honeysuckle, 15 g of Achyranthes bidentata, 12 g of Raw Fructus Rhizome, Composed of 16g of Danshen, 10g of Curcuma, 16g of Chuanxiong, 15g of Radix Paeoniae Rubra, 15g of Ginseng, 18g of Ophiopogon japonicus and 20g of Schisandra.

Example 56:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 25g of Gypsum, 22g of Anemarrhena, 15g of Rehmannia Radix, 15g of Honeysuckle, 10g of Achyranthes bidentata, 12g of Raw Fructus Rhizome, Composed of 12g of Danshen, 9g of Curcuma, 12g of Chuanxiong, 10g of Radix Paeoniae Rubra, 12g of Ginseng, 15g of Ophiopogon japonicus and 12g of Schisandra.

Example 57:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 50 g of gypsum, 13 g of Anemarrhena, 18 g of Rehmannia glutinosa, 12 g of honeysuckle, 11 g of Achyranthes bidentata, 13 g of Shengzizi, Composed of 12g of Danshen, 11g of Curcuma, 15g of Chuanxiong, 12g of Radix Paeoniae Rubra, 12g of American Ginseng, 16g of Ophiopogon japonicus and 25g of Schisandra.

Example 58:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are composed of gypsum 100g, Anemarrhena 25g, Shengdi 22g, honeysuckle 25g, Achyranthes bidentata 18g, Shengzizi 18g, Composed of 17g of Danshen, 15g of Curcuma, 18g of Chuanxiong, 10g of Radix Paeoniae Rubra, 15g of American Ginseng, 18g of Radix Ophiopogon japonicus and 22g of Schisandra.

Example 59:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 120 g of gypsum, 30 g of Anemarrhena, 28 g of Rehmannia Radix, 22 g of honeysuckle, 15 g of Achyranthes bidentata, 15 g of Shengzizi, Composed of 18g of Danshen, 12g of Curcuma, 15g of Chuanxiong, 15g of Radix Paeoniae Rubra, 14g of American Ginseng, 12g of Radix Ophiopogon japonicus and 18g of Schisandra.

Example 60:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 150g of Gypsum, 18g of Anemarrhena, 30g of Rehmannia Radix, 16g of Honeysuckle, 16g of Achyranthes bidentata, 17g of Raw Fructus Rhizome, Composed of 16g of Danshen, 15g of Curcuma, 13g of Chuanxiong, 11g of Radix Paeoniae Rubra, 12g of American Ginseng, 14g of Ophiopogon japonicus and 16g of Schisandra.

Example 61:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the traditional Chinese medicine composition are 100 g of raw gypsum, 18 g of Anemarrhena anemarrhena, 15 g of Rehmannia glutinosa, 16 g of honeysuckle, 10 g of Achyranthes bidentata, 15 g of Shengzizi, Composition of 15g of Danshen, 15g of Curcuma, 22g of Rhizoma Chuanxiong, 12g of Radix Paeoniae Rubra, 15g of Rhizoma Imperatae and 1.5g of Radix Notoginseng.

Example 62:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 120g of gypsum, 22g of Zhimu, 28g of Shengdi, 18g of honeysuckle, 9g of Achyranthes bidentata, 12g of Shengzizi, Composed of 12g of Danshen, 10g of Curcuma, 18g of Chuanxiong, 10g of Radix Paeoniae Rubra, 16g of Rhizoma Imperatae and 2.0g of Panax notoginseng powder.

Example 63:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 150 g of raw gypsum, 20 g of Zhimu, 22 g of Rehmannia Radix, 15 g of Flos Lonicerae, 12 g of Achyranthes bidentata, 13 g of Shengzizi, Composed of 13g of Danshen, 10g of Curcuma, 15g of Chuanxiong, 10g of Radix Paeoniae Rubra, 18g of Rhizoma Imperatae and 3g of Radix Notoginseng.

Example 64:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the traditional Chinese medicine composition are 80 g of raw gypsum, 15 g of Anemarrhena, 30 g of raw land, 12 g of honeysuckle, 10 g of Achyranthes bidentata, 16 g of raw gypsum, Composed of 16g of Danshen, 9g of Curcuma, 20g of Chuanxiong, 15g of Radix Paeoniae Rubra, 15g of Rhizoma Imperatae and 2g of Radix Notoginseng.

Example 65:

The present invention is used for the treatment of the traditional Chinese medicine composition of acute renal failure, expressed in parts by weight, the crude drug of the Chinese medicinal composition is composed of raw gypsum 140g, Zhimu 23g, Shengdi 25g, honeysuckle 20g, Achyranthes bidentata 9g, Shengzizi 18g, Composed of 18g of Danshen, 12g of Curcuma, 12g of Rhizoma Chuanxiong, 13g of Radix Paeoniae Rubra, 16g of Rhizoma Imperatae and 3g of Radix Notoginseng.

Example 66:

The present invention is used for the treatment of acute renal failure Chinese medicine composition, expressed in parts by weight, the crude drug of the Chinese medicine composition is composed of raw gypsum 25g, Anemarrhena 20g, Shengdi 18g, honeysuckle 18g, Achyranthes bidentata 10g, Shengzizi 12g, Composition of 13g of Danshen, 10g of Curcuma, 23g of Chuanxiong, 10g of Radix Paeoniae Rubra, 16g of Rhizoma Imperatae and 1.5g of Radix Notoginseng.

Example 67:

The present invention is used for the treatment of acute renal failure Chinese medicine composition, expressed in parts by weight, the crude drug of the Chinese medicine composition consists of raw gypsum 50g, Anemarrhena 15g, Radix Rehmannia 20g, honeysuckle 15g, Achyranthes bidentata 10g, Shengzizi 15g, Composed of 15g of Danshen, 9g of Curcuma, 12g of Chuanxiong, 12g of Radix Paeoniae Rubra, 18g of Rhizoma Imperatae and 3g of Radix Notoginseng.

Example 68:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 135g of Gypsum, 25g of Anemarrhena, 25g of Rehmannia Radix, 20g of Honeysuckle, 12g of Achyranthes bidentata, 13g of Raw Fructus Rhizome, Composition of 12g of Danshen, 15g of Curcuma, 16g of Chuanxiong, 15g of Radix Paeoniae Rubra, 18g of Rhizoma Imperatae and 1.5g of Radix Notoginseng.

Example 69:

The present invention is used for the treatment of acute renal failure Chinese medicine composition, expressed in parts by weight, the crude drug of the Chinese medicine composition is composed of raw gypsum 75g, Zhimu 18g, Shengdi 30g, honeysuckle 15g, Achyranthes bidentata 12g, Shengzizi 15g, Composition of 14g of Danshen, 10g of Curcuma, 15g of Chuanxiong, 12g of Radix Paeoniae Rubra, 26g of Dandelion and 16g of Forsythia.

Example 70:

The traditional Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicinal composition are 90g of gypsum, 22g of Anemarrhena, 25g of Radix Rehmanniae, 18g of honeysuckle, 11g of Achyranthes bidentata, 13g of Shengzizi, Composition of 16g of Danshen, 13g of Curcuma, 20g of Chuanxiong, 16g of Radix Paeoniae Rubra, 28g of Dandelion and 17g of Forsythia.

Example 71:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are composed of gypsum 50g, Zhimu 15g, Shengdi 15g, honeysuckle 12g, Achyranthes bidentata 10g, Shengzizi 12g, Composition of 12g of Danshen, 9g of Curcuma, 12g of Chuanxiong, 10g of Radix Paeoniae Rubra, 25g of Dandelion and 15g of Forsythia.

Example 72:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 110g of gypsum, 26g of Zhimu, 22g of Shengdi, 13g of honeysuckle, 14g of Achyranthes bidentata, 16g of Shengzizi, Composition of Salvia 18g, Curcuma 10g, Chuanxiong 13g, Chishao 15g, Dandelion 26g and Forsythia 15g.

Example 73:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 130g of Gypsum, 20g of Anemarrhena, 20g of Radix Rehmanniae Radix, 16g of Honeysuckle, 12g of Achyranthes bidentata, 12g of Raw Fructus Rhizome, Composition of 15g of Danshen, 11g of Curcuma, 18g of Chuanxiong, 13g of Radix Paeoniae Rubra, 25g of Dandelion and 16g of Forsythia.

Example 74:

The Chinese medicine composition used for the treatment of acute renal failure according to the present invention is expressed in parts by weight. The raw materials of the Chinese medicine composition are 150g of Gypsum, 30g of Anemarrhena, 26g of Rehmannia Radix, 20g of Honeysuckle, 15g of Achyranthes bidentata, 18g of Raw Fructus Rhizome, Composition of 20g of Danshen, 15g of Curcuma, 25g of Chuanxiong, 18g of Radix Paeoniae Rubra, 30g of Dandelion and 18g of Forsythia.

Claims (10)

1. A Chinese medicine composition for the treatment of acute renal failure, characterized in that: expressed in parts by weight, the raw material of the Chinese medicine composition consists of gypsum 25～150g, Anemarrhena 12～25g, Rehmannia 15～30g, Composition of 10-25g of honeysuckle, 10-12g of Achyranthes bidentata, 12-18g of raw mast, 10-18g of salvia miltiorrhiza, 10-15g of turmeric, 12-18g of Chuanxiong and 10-15g of red peony. 2. A Chinese medicine composition for treating acute renal failure, characterized in that: expressed in parts by weight, the raw materials of the Chinese medicine composition are 25-150 g of raw gypsum, 12-25 g of Zhimu, 15-30 g of Rehmannia, 10-25g of honeysuckle, 10-12g of Achyranthes bidentata, 12-18g of raw mast, 10-18g of salvia miltiorrhiza, 10-15g of turmeric, 12-18g of Chuanxiong, 10-15g of red peony, 10-15g of bellflower, 10-15g of Baiqian , Chuanbei 10-15g, Tinglizi 10-12g and almond 6-10g. 3. A Chinese medicine composition for treating acute renal failure, characterized in that: expressed in parts by weight, the raw materials of the Chinese medicine composition are 25-50 g of raw gypsum, 12-25 g of Zhimu, 15-30 g of Rehmannia, 12-20g of honeysuckle, 9-12g of Achyranthes bidentata, 10-18g of raw mast, 10-18g of salvia miltiorrhiza, 8-15g of curcuma, 12-25g of Chuanxiong, 10-15g of red peony, 10-15g of bamboo and 6-6 9g composition. 4. A Chinese medicine composition for treating acute renal failure, characterized in that: expressed in parts by weight, the raw materials of the Chinese medicine composition are 25-50 g of raw gypsum, 12-25 g of Anemarrhena, 12-30 g of Rehmannia, Honeysuckle 10-25g, Achyranthes bidentata 9-15g, raw mast 10-18g, salvia miltiorrhiza 10-20g, turmeric 10-15g, chuanxiong 12-25g, red peony 10-18g, schisandra 12-25g and heterophylla 12-18g composition. 5. A traditional Chinese medicine composition for treating acute renal failure, characterized in that: expressed in parts by weight, the raw materials of the traditional Chinese medicine composition are 25-150 g of raw gypsum, 12-25 g of Zhimu, 12-30 g of Rehmannia, 12-25g of honeysuckle, 9-12g of Achyranthes bidentata, 12-18g of raw mast, 10-20g of salvia miltiorrhiza, 9-15g of curcuma, 12-25g of Chuanxiong, 10-15g of red peony, 10-15g of paeonol, 10-10g of sand ginseng 15g, Dendrobium 9-15g, Rhubarb 10-30g and Ophiopogon japonicus 10-15g. 6. A traditional Chinese medicine composition for treating acute renal failure, characterized in that: expressed in parts by weight, the raw materials of the Chinese medicinal composition are 25-150 g of raw gypsum, 12-30 g of Zhimu, 15-30 g of Rehmannia, Honeysuckle 10-25g, Achyranthes bidentata 9-15g, raw mast 10-18g, salvia miltiorrhiza 12-18g, turmeric 9-15g, Chuanxiong 12-25g, red peony 10-15g, Uncaria 9-10g and Shichangpu 9- 15g composition. 7. A traditional Chinese medicine composition for treating acute renal failure, characterized in that: expressed in parts by weight, the raw materials of the traditional Chinese medicine composition are 50-150 g of raw gypsum, 15-30 g of Zhimu, 15-30 g of Rehmannia, 12-20g of honeysuckle, 10-15g of Achyranthes bidentata, 12-18g of raw mast, 12-20g of salvia miltiorrhiza, 9-15g of turmeric, 12-25g of Chuanxiong, 10-18g of red peony, 25-30g of dandelion and 15-18g of forsythia composition. 8. A traditional Chinese medicine composition for treating acute renal failure, characterized in that: expressed in parts by weight, the raw materials of the Chinese medicinal composition are 30-150 g of raw gypsum, 15-30 g of Zhimu, 15-30 g of Rehmannia, Honeysuckle 12-25g, Achyranthes bidentata 12-18g, Raw Sternum 12-18g, Salvia miltiorrhiza 12-20g, Curcuma 9-15g, Chuanxiong 12-18g, Radix Paeoniae Rubra 10-18g, Patrinia 15-30g, Bletilla striata 10- 12g, each 10-15g of large and small thistles, 10-20g of buffalo horn and 1.5g of amber powder or Angong Niuhuang Wan. 9. A traditional Chinese medicine composition for treating acute renal failure, characterized in that: expressed in parts by weight, the raw materials of the traditional Chinese medicine composition are 25-150 g of raw gypsum, 12-30 g of Zhimu, 15-30 g of Rehmannia, Honeysuckle 12-25g, Achyranthes bidentata 10-18g, Raw mast 12-18g, Salvia miltiorrhiza 12-18g, Curcuma 9-15g, Chuanxiong 12-18g, Radix Paeoniae Rubra 10-15g, Ginseng or American ginseng 12-15g, Ophiopogon japonicus 10 ～18g and Schisandra 12～25g. 10. A traditional Chinese medicine composition for treating acute renal failure, characterized in that: expressed in parts by weight, the raw materials of the traditional Chinese medicine composition are 25-150 g of raw gypsum, 15-25 g of Zhimu, 15-30 g of Rehmannia, 12-20g of honeysuckle, 9-12g of Achyranthes bidentata, 12-18g of raw mast, 12-18g of salvia miltiorrhiza, 9-15g of curcuma, 12-25g of Chuanxiong, 10-15g of red peony root, 15-18g of rhizoma rhizome and 1.5 ~3g composition.