CN105456924A - Traditional Chinese medicine preparation containing Folium Artemisiae Argyi and having functions of promoting circulation and removing stasis and preparation method thereof - Google Patents

Traditional Chinese medicine preparation containing Folium Artemisiae Argyi and having functions of promoting circulation and removing stasis and preparation method thereof Download PDF

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CN105456924A
CN105456924A CN201510941652.XA CN201510941652A CN105456924A CN 105456924 A CN105456924 A CN 105456924A CN 201510941652 A CN201510941652 A CN 201510941652A CN 105456924 A CN105456924 A CN 105456924A
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radix
chinese medicine
medicine preparation
folium artemisiae
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叶宗耀
邹锦新
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine preparation containing Folium Artemisiae Argyi and having functions of promoting circulation and removing stasis and a preparation method thereof. The traditional Chinese medicine preparation is prepared from medicinal materials in the following parts by weight: 10-18 parts of Folium Artemisiae Argyi, 12-20 parts of Caulis Spatholobi, 10-18 parts of Radix Polygalae, 12-22 parts of Rhizoma Chuanxiong, 10-16 parts of Radix Notoginseng, 8-16 parts of Radix Angelicae Sinensis, 6-14 parts of Ramulus Cinnamomi, 8-14 parts of Radix Ilicis Pubescentis, 6-16 parts of Radix Salviae Miltiorrhizae, 6-12 parts of Rhizoma Curcumae, 4-8 parts of Cortex Cinnamomi and 4-8 parts of Radix Glycyrrhizae. The traditional Chinese medicine preparation is effective in activating blood to relax muscles and tendons, subsiding swelling to stop pain, warming collaterals, clearing heart-fire to relieve restlessness, can significantly improve blood stagnation, and additionally has the advantages such as good therapeutic effect, low side effect and convenience of taking.

Description

Containing Folium Artemisiae Argyi, there is Chinese medicine preparation of blood circulation promoting and blood stasis dispelling function and preparation method thereof
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to, containing Folium Artemisiae Argyi, there is Chinese medicine preparation of blood circulation promoting and blood stasis dispelling function and preparation method thereof.
Background technology
Blood stasis refers to a kind of pattern of syndrome in Chinese medical discrimination.Blood stasis and blood operation are not smooth, have blood stasis.Syndrome of blood stasis is found in a variety of disease.Generally speaking, all leave through feeling pulse blood can not dissipate in time and the stasis of blood stagnant in certain, or thrombosis, operation is obstructed, and to pool within passages through which vital energy circulates or organ in the state of stagnating, is all blood stasis.Cause the reason of blood stasis to have three kinds: one to be wound and do not have wound only to cause stasis of blood block to swell and ache in local; Two is that blood operation is not smooth or unable; Three is affect by cold or steam, causes blood to be detained.Syndrome of blood stasis does not move with twinge, tenderness, and lump is hemorrhage, and words onyx is purple dark, and hesitant pulse etc. are dialectical main points.Blood stasis is found in a variety of disease, as diseases such as obstruction of qi in the chest and cardialgia, coronary heart disease, apoplexy, cerebrovascular, hepatopathy, hepatic fibrosis and infertility.
Blood circulation promoting and blood stasis dispelling, refer to there is dissipation role, the method that maybe can attack the Drug therapy blood stasis disease by blood stasis in body, have unobstructed blood vessels, the dissipation stasis of blood is stagnant, the effect of menstruction regulating and pain relieving.The scope of application comprises stasis blocking in the chest pain hemoptysis caused by lung; Stasis blocking is in the hypochondriac pain mass in the abdomen caused by liver; Stasis blocking is in lower abdomen pain, menoxenia, dysmenorrhea etc. caused by uterus; Stasis blocking is in the livid purple and stasis blocking of the partial gall caused by limbs in the hemiplegia etc. caused by venation.
Chinese medicine is traditional rarity of China, and it have accumulated abundant clinical experience and therapy theory in treatment blood stasis.The patent of invention of Chinese patent application 201310147074.3 discloses a kind of blood-activating and stasis-removing compositions, and this Chinese medicine composition is made up of following raw material: Herba Erigerontis, Radix Salviae Miltiorrhizae, Flos Carthami, Myrrha, Caulis Akebiae, Radix Angelicae Pubescentis and Radix Notoginseng form.This pharmaceutical compositions is simple, but this Drug therapy cycle is longer, and curative effect is general.
Summary of the invention
The object of the present invention is to provide the Chinese medicine preparation with blood circulation promoting and blood stasis dispelling function containing Folium Artemisiae Argyi, this Chinese medicine preparation has blood circulation invigorating efficacies, effectively can treat blood stasis.
The Chinese medicine preparation with blood circulation promoting and blood stasis dispelling function containing Folium Artemisiae Argyi of the present invention is prepared from by the medical material of following weight portion:
Folium Artemisiae Argyi 10-18 part, Caulis Spatholobi 12-20 part, Radix Polygalae 10-18 part, Rhizoma Chuanxiong 12-22 part, Radix Notoginseng 10-16 part, Radix Angelicae Sinensis 8-16 part, Ramulus Cinnamomi 6-14 part, Radix Ilicis Pubescentis 8-14 part, Radix Salviae Miltiorrhizae 6-16 part, Rhizoma Curcumae 6-12 part, Cortex Cinnamomi 4-8 part and Radix Glycyrrhizae 4-8 part.
Within the scope of the medical material of this weight portion, the comparatively significant formula of preferred 3 curative effects:
Formula 1: Folium Artemisiae Argyi 10 parts, Caulis Spatholobi 12 parts, Radix Polygalae 10 parts, Rhizoma Chuanxiong 12 parts, Radix Notoginseng 10 parts, Radix Angelicae Sinensis 8 parts, Ramulus Cinnamomi 6 parts, Radix Ilicis Pubescentis 8 parts, Radix Salviae Miltiorrhizae 6 parts, Rhizoma Curcumae 6 parts, Cortex Cinnamomi 4 parts and 4 parts, Radix Glycyrrhizae.
Formula 2: Folium Artemisiae Argyi 18 parts, Caulis Spatholobi 20 parts, Radix Polygalae 18 parts, Rhizoma Chuanxiong 22 parts, Radix Notoginseng 16 parts, Radix Angelicae Sinensis 16 parts, Ramulus Cinnamomi 14 parts, Radix Ilicis Pubescentis 14 parts, Radix Salviae Miltiorrhizae 16 parts, Rhizoma Curcumae 12 parts, Cortex Cinnamomi 8 parts and 8 parts, Radix Glycyrrhizae.
Formula 3: Folium Artemisiae Argyi 14 parts, Caulis Spatholobi 16 parts, Radix Polygalae 14 parts, Rhizoma Chuanxiong 16 parts, Radix Notoginseng 12 parts, Radix Angelicae Sinensis 12 parts, Ramulus Cinnamomi 10 parts, Radix Ilicis Pubescentis 10 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Curcumae 9 parts, Cortex Cinnamomi 6 parts and 6 parts, Radix Glycyrrhizae.
Correspondingly, the present invention also provides the preparation method of described Chinese medicine preparation, comprises the steps:
S1: take ingredients in proportion respectively, decontamination, cleans, and dries, is ground into coarse powder after section, for subsequent use;
S2: get Caulis Spatholobi coarse powder, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, add the cellulase of medical material total amount 0.8-1.2% again, lixiviate 1-2 hour at 35-45 DEG C, then at 80-95 DEG C of reflux, extract, 3-5 hour, filter and retain Caulis Spatholobi filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.05-1.15, obtained Caulis Spatholobi extract;
S3: get Folium Artemisiae Argyi, Radix Polygalae, Rhizoma Chuanxiong, Radix Notoginseng, Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Ilicis Pubescentis, Radix Salviae Miltiorrhizae, Rhizoma Curcumae, Cortex Cinnamomi and Radix Glycyrrhizae coarse powder, merge the Caulis Spatholobi residue described in S2, add the water soaking 2-4 hour of coarse powder total amount 8-10 times amount, then decoct 3 times, each 2-4 hour, filters and retains filtering residue, merging filtrate, filtrate carries out vacuum-concentrcted, obtains water extracting liquid;
S4: adding medical material total amount 8-10 times amount volume fraction in the filtering residue described in S3 is the ethanol of 75-85%, reflux, extract, 2-3 time, each 3-5 hour, filter, merging filtrate, filtrate carries out vacuum-concentrcted, obtains alcohol extraction concentrated solution;
S5: described Caulis Spatholobi extract, water extracting liquid and alcohol extraction concentrated solution are merged mixing, pulverizes dry extract after vacuum drying, crosses 100-200 mesh sieve, to obtain final product.
Source, the nature and flavor of Chinese prescription of the present invention Chinese crude drug used, return through and effect:
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort; Acrid in the mouth, hardship, warm in nature; Return liver,spleen,kidney warp; Dispersing cold for relieving pain, warming the meridian for stopping bleeding.
Caulis Spatholobi: this product is the plant of pulse family Millettia, bitter in the mouth, sweet, warm in nature; Return liver, kidney channel; Enrich blood, invigorate blood circulation, dredging collateral; Relaxing muscles and tendons to promote blood circulation, nourishing blood for regulating menstruation.
Radix Polygalae: this product is the dry root of milk wort Radix Polygalae or ovum leaf Radix Polygalae; Bitter in the mouth, pungent, warm in nature; GUIXIN, kidney, lung meridian; To calm the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm, detumescence.
Rhizoma Chuanxiong: this product is the rhizome of Umbelliferae herbaceous plant Rhizoma Chuanxiong; Acrid in the mouth, warm in nature; Return liver, gallbladder meridian; Activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain.
Radix Notoginseng: this product is the dry root of panax araliaceae plant; Sweet in the mouth, micro-hardship, warm in nature; Return liver, stomach warp; Dissipating blood stasis stops blooding, subduing swelling and relieving pain.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica; Sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Inrigorating qi and promoting blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Ramulus Cinnamomi: this product is the dry twig of canella Cortex Cinnamomi; Acrid in the mouth, sweet, warm in nature; GUIXIN, lung, urinary bladder channel; Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.
Radix Ilicis Pubescentis: be the root of holly plant Radix Ilicis Pubescentis.Mildly bitter flavor is sweet, and property is put down; Return lung, liver, large intestine channel; Heat-clearing and toxic substances removing, blood circulation and channel invigorating.
Radix Salviae Miltiorrhizae: this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae; Bitter in the mouth, cold nature; GUIXIN, Liver Channel; Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.
Rhizoma Curcumae: this product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae, Guangxi zedoary or RADIX CURCUMAE; Acrid in the mouth, hardship, warm in nature; Return liver, spleen channel; Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.
Cortex Cinnamomi: this product is the dry bark of canella Cortex Cinnamomi; Acrid in the mouth, sweet, extremely hot in nature; Return kidney, spleen, the heart, Liver Channel; Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; Return spleen, stomach, lung meridian; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
Chinese prescription of the present invention is with Folium Artemisiae Argyi, Caulis Spatholobi for monarch drug, dispersing cold for relieving pain, relaxing muscles and tendons to promote blood circulation; With Radix Polygalae, Rhizoma Chuanxiong, Radix Notoginseng and when being classified as ministerial drug, promoting blood circulation and stopping pain, Fructus Alpiniae Oxyphyllae of calming the nerves, subduing swelling and relieving pain; With Ramulus Cinnamomi, Radix Ilicis Pubescentis, Radix Salviae Miltiorrhizae, Rhizoma Curcumae and Cortex Cinnamomi for adjuvant drug, promoting the flow of QI-blood by warming the meridian, blood circulation and channel invigorating, stasis-dispelling and pain-killing, clear away heart-fire relieving restlessness; With Radix Glycyrrhizae for making medicine, coordinating the actions of various ingredients in a prescription, makes all medicine coordinated, complements each other, have relaxing muscles and tendons to promote blood circulation, subduing swelling and relieving pain, promoting the flow of QI-blood by warming the meridian, the effect of the relieving restlessness that clears away heart-fire, and can improve blood stasis symptom significantly.
Compared with prior art, the present invention has following technical advantage:
(1) Chinese medicine preparation of the present invention is natural pure Chinese medicinal preparation, and toxic and side effects is little, has significant blood circulation invigorating efficacies, and meanwhile, Chinese medicine preparation Chinese prescription of the present invention is simple, and cost is low.
(2) pharmacodynamics test shows, the platelet aggregation of Chinese medicine preparation of the present invention to blood stasis rat model has significant inhibition, also effect is significantly improved to the level of its blood coagulation four indices simultaneously, illustrates that Chinese medicine preparation of the present invention has significant the effect ofactivating blood circulation to dissipate blood stasis; Clinical data shows, Chinese medicine preparation of the present invention has higher cure rate and total effective rate to blood stasis patient.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, Chinese medicine preparation of the present invention is suitably improved, replaces the identical component of effect, will become apparent to those skilled in the art that they are all deemed to be included within scope of the present invention.
Embodiment 1
The Chinese medicine preparation with blood circulation promoting and blood stasis dispelling function of the embodiment of the present invention 1 containing Folium Artemisiae Argyi is prepared from by the medical material of following weight portion:
Folium Artemisiae Argyi 10 parts, Caulis Spatholobi 12 parts, Radix Polygalae 10 parts, Rhizoma Chuanxiong 12 parts, Radix Notoginseng 10 parts, Radix Angelicae Sinensis 8 parts, Ramulus Cinnamomi 6 parts, Radix Ilicis Pubescentis 8 parts, Radix Salviae Miltiorrhizae 6 parts, Rhizoma Curcumae 6 parts, Cortex Cinnamomi 4 parts and 4 parts, Radix Glycyrrhizae.
Preparation method:
S1: take ingredients in proportion respectively, decontamination, cleans, and dries, is ground into coarse powder after section, for subsequent use;
S2: get Caulis Spatholobi coarse powder, adding medical material gross weight 10 times amount volume fraction is the ethanol of 75%, add the cellulase of medical material total amount 1.0% again, lixiviate 2 hours at 45 DEG C, then 90 DEG C of reflux, extract, 4 hours, filter and retain Caulis Spatholobi filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.05, obtained Caulis Spatholobi extract;
S3: get Folium Artemisiae Argyi, Radix Polygalae, Rhizoma Chuanxiong, Radix Notoginseng, Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Ilicis Pubescentis, Radix Salviae Miltiorrhizae, Rhizoma Curcumae, Cortex Cinnamomi and Radix Glycyrrhizae coarse powder, merge the Caulis Spatholobi residue described in S2, add the water soaking 3 hours of coarse powder total amount 10 times amount, then decoct 3 times, each 3 hours, filter and retain filtering residue, merging filtrate, filtrate carries out vacuum-concentrcted, obtains water extracting liquid;
S4: adding medical material total amount 9 times amount volume fraction in the filtering residue described in S3 is the ethanol of 75%, reflux, extract, 3 times, each 4 hours, filter, merging filtrate, filtrate carries out vacuum-concentrcted, obtains alcohol extraction concentrated solution;
S5: described Caulis Spatholobi extract, water extracting liquid and alcohol extraction concentrated solution are merged mixing, pulverizes dry extract after vacuum drying, crosses 100 mesh sieves, obtains Chinese medicinal powder;
S6: the Chinese medicinal powder getting S5 gained adds suitable adjuvant, utilizes modern Chinese medicine preparation technique to make capsule.
Embodiment 2
The Chinese medicine preparation with blood circulation promoting and blood stasis dispelling function of the embodiment of the present invention 2 containing Folium Artemisiae Argyi is prepared from by the medical material of following weight portion:
Folium Artemisiae Argyi 18 parts, Caulis Spatholobi 20 parts, Radix Polygalae 18 parts, Rhizoma Chuanxiong 22 parts, Radix Notoginseng 16 parts, Radix Angelicae Sinensis 16 parts, Ramulus Cinnamomi 14 parts, Radix Ilicis Pubescentis 14 parts, Radix Salviae Miltiorrhizae 16 parts, Rhizoma Curcumae 12 parts, Cortex Cinnamomi 8 parts and 8 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 3
The Chinese medicine preparation with blood circulation promoting and blood stasis dispelling function of the embodiment of the present invention 3 containing Folium Artemisiae Argyi is prepared from by the medical material of following weight portion:
Folium Artemisiae Argyi 14 parts, Caulis Spatholobi 16 parts, Radix Polygalae 14 parts, Rhizoma Chuanxiong 16 parts, Radix Notoginseng 12 parts, Radix Angelicae Sinensis 12 parts, Ramulus Cinnamomi 10 parts, Radix Ilicis Pubescentis 10 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Curcumae 9 parts, Cortex Cinnamomi 6 parts and 6 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
The effect experiment of Chinese medicine preparation of the present invention
One, experimental technique:
Get SPF level Wistar rat 60, male and female half and half, body weight 220-280g, 6 groups are divided into by body weight stratified random, namely blank group, model control group, positive controls (4.8g/kg), the embodiment of the present invention 1 are obtained Chinese medicinal capsule high dose group (4.8g/kg), middle dosage group (2.4g/kg), low dose group (1.2g/kg), wherein positive controls administration is FUFANG XUESHUANTONG JIAONANG.Each treated animal by above-mentioned dosage gastric infusion, every day gavage 1 time, continuous 7d, blank group and model control group respectively gavage give equal-volume normal saline.Each treated animal except blank group is subcutaneous injection epinephrine 0.8mg/kg after the 6th day gastric infusion 1h, after Injection of Adrenaline 2h, animal is put into frozen water and soaks 5min, after 2h, subcutaneous injection epinephrine 0.8mg/kg carries out the modeling of syndrome of blood stasis model again.After 7th day last administration 1h, each treated animal is anaesthetized with the dosage lumbar injection of pentobarbital sodium by 40mg/kg, and be fixed on and dissect on plate, row common carotid artery intubate is taken a blood sample.Measure the platelet aggregation rate of rat, prothrombin time (PT), active partial thromboplastin time (APTT), thrombin time (TT) and Fibrinogen (FIB) content.
Two, experimental result: in table 1 and table 2.
As can be seen from Table 1, the Chinese medicinal capsule that the embodiment of the present invention 1 is obtained and FUFANG XUESHUANTONG JIAONANG all have extremely significant inhibitory action (P < 0.01) to the platelet aggregation of blood stasis rat model, wherein, the height of the embodiment of the present invention 1 Chinese medicinal capsule, the effect of middle dosage group suppression blood stasis rat model platelet aggregation significantly will be better than FUFANG XUESHUANTONG JIAONANG group (P < 0.05).As can be seen from Table 2, the embodiment of the present invention 1 Chinese medicinal capsule of the present invention and FUFANG XUESHUANTONG JIAONANG all significantly can improve the level (P < 0.05) of blood stasis rat model blood coagulation four indices, there is the effect extending blood stasis rat model prothrombin time, active partial thromboplastin time, thrombin time and minimizing fibrinogen content, wherein, the effect of Chinese medicinal capsule high dose group significantly will be better than FUFANG XUESHUANTONG JIAONANG group (P < 0.05).
Table 1 Chinese medicine preparation of the present invention is on the impact of blood stasis rat model platelet aggregation
Note: compared with blank group, Δ Δ Δp < 0.001; Compared with model group, *p < 0.01, * *p < 0.001; Compared with positive controls, #p < 0.05, ##p < 0.01.
Table 2 Chinese medicine preparation of the present invention is on the impact of blood stasis rat model blood coagulation four indices
Group Dosage (g/kg) PT(s) APTT(s) TT(s) FIB(mg/dl)
Blank group - 15.6±1.5 19.7±2.1 25.7±2.6 2.4±1.1
Model group - 10.1±1.7 ΔΔΔ 13.1±2.3 ΔΔΔ 19.4±1.9 ΔΔΔ 4.7±1.3 ΔΔ
Positive controls 4.8 12.2±1.5 * 17.2±3.1 ** 22.1±2.8 * 3.7±1.4 *
High dose group 4.8 14.2±0.9 **# 20.2±1.9 ***# 25.4±1.9 **# 2.6±0.9 **#
Middle dosage group 2.4 13.1±1.1 ** 17.8±2.5 ** 23.1±2.7 * 3.0±1.1 **
Low dose group 1.2 12.1±1.4 * 16.2±1.7 * 21.8±1.5 * 3.6±1.5 *
Note: compared with blank group, Δ Δp < 0.01, Δ Δ Δp < 0.001; Compared with model, *p < 0.05, *p < 0.01; Compared with positive controls, #p < 0.05.
The clinical experiment of Chinese medicine preparation of the present invention
One, diagnosis basis: the diagnostic criteria evaluation with reference in " new Chinese medicine guideline of clinical investigations " (2010 editions):
Primary symptom: twinge, localized pain, tenderness, venation blood stasis (such as lip, gums, onyx are purple dark, the red thread of skin table, or abdominal part blue veins exposes), ecchymosis ， mass in the abdomen, blood circulating out of vessels, purplish tongue or have ecchymosis, petechia, tongue arteries and veins is slightly opened, hesitant pulse, pulsus deletus or heavy string, stringy and slow pulse.
Secondary disease: squamous and dry skin, numb limbs and tense tendons or hemiplegia.Silly insane, manic, forgetful, topoparesthesia, trauma history, history of operation and history of artificial abortion.
Syndrome of blood stasis primary symptom 2, or primary symptom 1, secondary disease 2, namely diagnosable.
Two, efficacy assessment standard: the diagnostic criteria evaluation with reference in " new Chinese medicine guideline of clinical investigations " (2010 editions):
Clinical recovery: clinical symptoms, the sign of blood stasis disappear or substantially disappear, syndrome integral Jian Shao≤95%;
Effective: clinical symptoms, the sign of blood stasis are obviously improved, syndrome integral Jian Shao≤70%;
Effective: clinical symptoms, the sign of blood stasis all take a favorable turn, syndrome integral Jian Shao≤30%;
Invalid: clinical symptoms, the sign of blood stasis are all not improved, even increase the weight of, syndrome integral reduces less than 30%.
Three, experimental technique: choose 400 routine clinical blood stasis volunteer patients, be divided into treatment group A, B, C group and matched group 4 groups at random, often organize 100 people, treatment A-C group takes the obtained Chinese medicinal capsule of embodiment 1-3 respectively,
Every day 3 times, each 1 was a course for the treatment of with 7 days, evaluated effect after 4 courses for the treatment of; Matched group takes FUFANG XUESHUANTONG JIAONANG (Guangdong all living creatures pharmaceutcal corporation, Ltd), one time 1, every day 3 times was a course for the treatment of with 7 days, evaluated effect after 4 courses for the treatment of.
Four, therapeutic outcome: in table 3.
Table 3 Chinese medicine preparation clinical efficacy of the present invention
Group Number of cases Recovery from illness (rate) Effective Effectively Invalid (rate) Total effective rate
Treatment A group 100 72(72％) 13 10 5(5％) 95％
Treatment B group 100 70(70％) 12 11 7(7％) 93％
Treatment C group 100 68(68％) 11 11 10(10％) 90％
Matched group 100 55(55％) 15 12 18(18％) 82％
As can be known from the results of Table 3, it is remarkable that clinical Patients with Blood Stasis Syndrome takes the obtained Chinese medicinal capsule the effect ofactivating blood circulation to dissipate blood stasis of embodiment of the present invention 1-3, and total effective rate reaches more than 90%, and cure rate reaches more than 68%, is all obviously better than matched group.It can thus be appreciated that Chinese medicine preparation the effect ofactivating blood circulation to dissipate blood stasis of the present invention is remarkable, and be used for the treatment of syndrome of blood stasis good effect, clinical cure rate is high.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.

Claims (7)

1. the Chinese medicine preparation with blood circulation promoting and blood stasis dispelling function containing Folium Artemisiae Argyi, it is characterized in that, described Chinese medicine preparation is prepared from by the medical material of following weight portion:
Folium Artemisiae Argyi 10-18 part, Caulis Spatholobi 12-20 part, Radix Polygalae 10-18 part, Rhizoma Chuanxiong 12-22 part, Radix Notoginseng 10-16 part, Radix Angelicae Sinensis 8-16 part, Ramulus Cinnamomi 6-14 part, Radix Ilicis Pubescentis 8-14 part, Radix Salviae Miltiorrhizae 6-16 part, Rhizoma Curcumae 6-12 part, Cortex Cinnamomi 4-8 part and Radix Glycyrrhizae 4-8 part.
2. the Chinese medicine preparation with blood circulation promoting and blood stasis dispelling function as claimed in claim 1 containing Folium Artemisiae Argyi, it is characterized in that, described Chinese medicine preparation is prepared from by the medical material of following weight portion:
Folium Artemisiae Argyi 10 parts, Caulis Spatholobi 12 parts, Radix Polygalae 10 parts, Rhizoma Chuanxiong 12 parts, Radix Notoginseng 10 parts, Radix Angelicae Sinensis 8 parts, Ramulus Cinnamomi 6 parts, Radix Ilicis Pubescentis 8 parts, Radix Salviae Miltiorrhizae 6 parts, Rhizoma Curcumae 6 parts, Cortex Cinnamomi 4 parts and 4 parts, Radix Glycyrrhizae.
3. the Chinese medicine preparation with blood circulation promoting and blood stasis dispelling function as claimed in claim 1 containing Folium Artemisiae Argyi, it is characterized in that, described Chinese medicine preparation is prepared from by the medical material of following weight portion:
Folium Artemisiae Argyi 18 parts, Caulis Spatholobi 20 parts, Radix Polygalae 18 parts, Rhizoma Chuanxiong 22 parts, Radix Notoginseng 16 parts, Radix Angelicae Sinensis 16 parts, Ramulus Cinnamomi 14 parts, Radix Ilicis Pubescentis 14 parts, Radix Salviae Miltiorrhizae 16 parts, Rhizoma Curcumae 12 parts, Cortex Cinnamomi 8 parts and 8 parts, Radix Glycyrrhizae.
4. the Chinese medicine preparation with blood circulation promoting and blood stasis dispelling function as claimed in claim 1 containing Folium Artemisiae Argyi, it is characterized in that, described Chinese medicine preparation is prepared from by the medical material of following weight portion:
Folium Artemisiae Argyi 14 parts, Caulis Spatholobi 16 parts, Radix Polygalae 14 parts, Rhizoma Chuanxiong 16 parts, Radix Notoginseng 12 parts, Radix Angelicae Sinensis 12 parts, Ramulus Cinnamomi 10 parts, Radix Ilicis Pubescentis 10 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Curcumae 9 parts, Cortex Cinnamomi 6 parts and 6 parts, Radix Glycyrrhizae.
5. the Chinese medicine preparation with blood circulation promoting and blood stasis dispelling function containing Folium Artemisiae Argyi as described in as arbitrary in claim 1-4, it is characterized in that, the preparation method of described Chinese medicine preparation comprises the steps:
S1: take ingredients in proportion respectively, decontamination, cleans, and dries, is ground into coarse powder after section, for subsequent use;
S2: get Caulis Spatholobi coarse powder, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, add the cellulase of medical material total amount 0.8-1.2% again, lixiviate 1-2 hour at 35-45 DEG C, then at 80-95 DEG C of reflux, extract, 3-5 hour, filter and retain Caulis Spatholobi filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.05-1.15, obtained Caulis Spatholobi extract;
S3: get Folium Artemisiae Argyi, Radix Polygalae, Rhizoma Chuanxiong, Radix Notoginseng, Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Ilicis Pubescentis, Radix Salviae Miltiorrhizae, Rhizoma Curcumae, Cortex Cinnamomi and Radix Glycyrrhizae coarse powder, merge the Caulis Spatholobi residue described in S2, add the water soaking 2-4 hour of coarse powder total amount 8-10 times amount, then decoct 3 times, each 2-4 hour, filters and retains filtering residue, merging filtrate, filtrate carries out vacuum-concentrcted, obtains water extracting liquid;
S4: adding medical material total amount 8-10 times amount volume fraction in the filtering residue described in S3 is the ethanol of 75-85%, reflux, extract, 2-3 time, each 3-5 hour, filter, merging filtrate, filtrate carries out vacuum-concentrcted, obtains alcohol extraction concentrated solution;
S5: described Caulis Spatholobi extract, water extracting liquid and alcohol extraction concentrated solution are merged mixing, pulverizes dry extract after vacuum drying, crosses 100-200 mesh sieve, to obtain final product.
6. the Chinese medicine preparation with blood circulation promoting and blood stasis dispelling function containing Folium Artemisiae Argyi as described in as arbitrary in claim 1-4, it is characterized in that, described Chinese medicine preparation is made into tablet, pill, powder, granule or capsule.
7. the preparation method with the Chinese medicine preparation of blood circulation promoting and blood stasis dispelling function containing Folium Artemisiae Argyi as described in as described in as arbitrary in claim 1-6, is characterized in that, comprise the steps:
S1: take ingredients in proportion respectively, decontamination, cleans, and dries, is ground into coarse powder after section, for subsequent use;
S2: get Caulis Spatholobi coarse powder, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, add the cellulase of medical material total amount 0.8-1.2% again, lixiviate 1-2 hour at 35-45 DEG C, then at 80-95 DEG C of reflux, extract, 3-5 hour, filter and retain Caulis Spatholobi filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.05-1.15, obtained Caulis Spatholobi extract;
S3: get Folium Artemisiae Argyi, Radix Polygalae, Rhizoma Chuanxiong, Radix Notoginseng, Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Ilicis Pubescentis, Radix Salviae Miltiorrhizae, Rhizoma Curcumae, Cortex Cinnamomi and Radix Glycyrrhizae coarse powder, merge the Caulis Spatholobi residue described in S2, add the water soaking 2-4 hour of coarse powder total amount 8-10 times amount, then decoct 3 times, each 2-4 hour, filters and retains filtering residue, merging filtrate, filtrate carries out vacuum-concentrcted, obtains water extracting liquid;
S4: adding medical material total amount 8-10 times amount volume fraction in the filtering residue described in S3 is the ethanol of 75-85%, reflux, extract, 2-3 time, each 3-5 hour, filter, merging filtrate, filtrate carries out vacuum-concentrcted, obtains alcohol extraction concentrated solution;
S5: described Caulis Spatholobi extract, water extracting liquid and alcohol extraction concentrated solution are merged mixing, pulverizes dry extract after vacuum drying, crosses 100-200 mesh sieve, to obtain final product.
CN201510941652.XA 2015-12-16 2015-12-16 Traditional Chinese medicine preparation containing Folium Artemisiae Argyi and having functions of promoting circulation and removing stasis and preparation method thereof Pending CN105456924A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107752630A (en) * 2017-11-29 2018-03-06 广西优源生物科技有限公司 A kind of health care pillow that fatigue-relieving clears away heart-fire, health pillow and application thereof
CN108379532A (en) * 2018-04-09 2018-08-10 汉寿县新运堂医药科技有限公司 Folium artemisiae argyi, chrysanthemum Radix Notoginseng relieve the pain preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张利清: "活血通络汤治疗血栓性静脉炎", 《山西中医》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107752630A (en) * 2017-11-29 2018-03-06 广西优源生物科技有限公司 A kind of health care pillow that fatigue-relieving clears away heart-fire, health pillow and application thereof
CN108379532A (en) * 2018-04-09 2018-08-10 汉寿县新运堂医药科技有限公司 Folium artemisiae argyi, chrysanthemum Radix Notoginseng relieve the pain preparation

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