CN103169899B - Drug for treating hydrops articuli - Google Patents

Abstract

The invention relates to a drug for treating hydrops articuli. The common symptoms of the hydrops articuli are arthralgia, pressing pain, lightly limited movement, claudication by accident, erythrocyte sedimentation rate, white blood cell count, most of normal C reaction proteins, and no bacterium found in joint puncture fluid examination and cell culture; and the hydrops articuli can be seen in imageological examination. The inventor can find out the traditional Chinese medicine oral liquid with a better curative effect for treating the hydrops articuli by clinical verification finally. The dosage of the drug component disclosed by the invention is fumbled by the inventor; the optimum proportions are 10 parts of ephedra, 10 parts of as arum, 25 parts of radix stephaniae tetrandrae, 25 parts of rhizoma smilacis glabrae, 20 parts of earthworm, 20 parts of radix achyranthis bidentatae, 10 parts of radix aconiti agrestis, 20 parts of rhizoma atractylodis, 30 parts of Lingxian (Chinese character), 20 parts of rhizoma curculiginis 25 parts of fleece-flower root, 30 parts of astragali radix and 30 parts of tuckahoe. By adopting these drug compositions, each drug can generate a synergistic effect; the drug has the effects of expelling wind and removing cold, and inducing resuscitation and alleviating pain, so as to effectively treat the hydrops articuli.

Description

A kind of medicine for the treatment of hydrarthrosis

Technical field

The present invention relates to a kind of Chinese herbal medicine, especially a kind of Chinese herbal medicine for the treatment of hydrarthrosis.

Background technology

Hydrarthrosis common sympton is arthralgia, can have tenderness, and activity is slightly limited, accidental limping, and how normal erythrocyte sedimentation rate, numeration of leukocyte, c reactive protein be, and arthrocentesiS fluid inspection and cell culture can not find antibacterial, imaging examination visible joint hydrops.

Summary of the invention

The present inventor through studying for a long period of time, and passes through the checking repeatedly of clinical trial, and finally have found the extract oral medicine being used for the treatment of hydrarthrosis of better curative effect, this medicine has expelling wind and cold, understand things pain-stopping curative effect.

Technical assignment of the present invention is to provide a kind of Chinese medicine composition of more efficiently treatment hydrarthrosis.Medicament selection Herba Ephedrae of the present invention, Herba Asari, Radix Stephaniae Tetrandrae, Rhizoma Smilacis Glabrae, Pheretima, Radix Achyranthis Bidentatae, Radix Aconiti Kusnezoffii, Rhizoma Atractylodis, Radix Clematidis, Rhizoma Curculiginis, the Radix Polygoni Multiflori, Radix Astragali, Poria combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat hydrarthrosis.Wherein: Herba Ephedrae: be the herb stem of Ephedraceae draft shape undershrub Ephedra sinica, ephedra equisetina and epheday intermedia.Property pungent, micro-hardship, temperature.Return lung, urinary bladder channel.Relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, inducing diuresis to remove edema.

Herba Asari: be the herb of Aristolochiaceae herbaceos perennial Herba Asari, Seoul Herba Asari or magnificent Herba Asari.Property pungent, temperature.Slightly poisonous.Return lung, kidney, heart channel.Expelling wind and cold, sensible, pain relieving, warming the lung to resolve fluid-retention.

Radix Stephaniae Tetrandrae: be the root of Menispermaceae perennial bejuco Radix stephaniae tetrandrae or Aristolochiaceae perennial voluble herb plant Radix Aristolochiae Fangchi.Property bitter, acrid, cold.Return bladder, kidney, spleen channel.Wind-damp dispelling, pain relieving, inducing diuresis to remove edema.

Rhizoma Smilacis Glabrae: be the tuber of Liliaceae liana light leaf greenbrier.Sweet, light, the micro-hardship of property, is slightly cold.Return liver, stomach, urinary bladder channel.Heat-clearing and toxic substances removing, eliminating damp-heat.

Pheretima: be the Scorpio body of Ju Yin section animal Pheretima aspergillum or Allolobophora caliginosa trapezoides.Property salty, cold.Return liver, spleen, urinary bladder channel.Clearing heat for calming endogenous wind, dredging collateral, relievings asthma, diuresis.

Radix Achyranthis Bidentatae: be the root of Amaranthaceae herbaceos perennial Radix Achyranthis Bidentatae and Radix Cyathulae.Pungent, the bitter, sweet, flat of property.Return liver, kidney channel.There is blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney, bone and muscle strengthening, conducting blood to flow downwards, effect of inducing diuresis for treating stranguria syndrome.

Radix Aconiti Kusnezoffii: be the tuber of the perennial wild plant Aconitum kusnezoffii Reichb of Ranunculaceae.Property pungent, bitter, heat.Very toxic.GUIXIN, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic, anemofrigid-damp arthralgia, arthralgia.Trusted subordinate's cold type of pain, colic of cold type is had a pain, traumatic injury pain, has the effect of narcotic analgesic.

Rhizoma Atractylodis: be the rhizome of Compositae herbaceos perennial Atractylodes lancea (Thunb.) DC. or Atractylis chinensis.Property pungent, bitter, temperature.Return spleen, stomach warp.Drying damp and strengthening spleen, wind-damp dispelling.

Radix Clematidis: be the rhizome of climbing up by holding on to property of Ranunculaceae shrub plant Radix Clematidis.Property is pungent, bitter, tepor.Return liver, kidney channel.Wind-damp dispelling, the meridian dredging, pain relieving.

Rhizoma Curculiginis: be the rhizome of Amaryllidaceae herbaceos perennial Rhizoma Curculiginis.Property pungent, heat.Poisonous.Return kidney, liver spleen channel.Warming the kidney to invigorate YANG, bone and muscle strengthening, dispelling cold and dampness.

The Radix Polygoni Multiflori: be the tuber of polygonum multiflorum thunb.Property is bitter, sweet, puckery, tepor.Return Liver and kidney warp.Invigorating the liver and kidney, benefiting essence-blood.

Radix Astragali: be the root of the pulse family herbaceos perennial Radix Astragali.Property is sweet, tepor.Return spleen, lung meridian.Spleen reinforcing lung qi, ascending up spleen-Qi and Yang, benefit defends consolidating superficial resistance, diuresis, promoting pus discharge and tissue regeneration strengthening.

Poria: be the sclerotium of On Polyporaceae Poria.Property sweet, light, flat.GUIXIN, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing.

The consumption of drug component of the present invention is also groped to draw through inventor in a large number, and each amounts of components is for have good curative effect in following weight proportioning: Herba Ephedrae 3-10 part, Herba Asari 2-10 part, Radix Stephaniae Tetrandrae 5-25 part, Rhizoma Smilacis Glabrae 15-60 part, Pheretima 5-20 part, Radix Achyranthis Bidentatae 5-20 part, Radix Aconiti Kusnezoffii 3-10 part, Rhizoma Atractylodis 5-20 part, Radix Clematidis 6-30 part, Rhizoma Curculiginis 3-20 part, Radix Polygoni Multiflori 9-25 part, Radix Astragali 30-60 part, Poria 10-30 part.

Its optimum proportioning is: 10 parts, Herba Ephedrae, Herba Asari 10 parts, Radix Stephaniae Tetrandrae 25 parts, Rhizoma Smilacis Glabrae 25 parts, Pheretima 20 parts, Radix Achyranthis Bidentatae 20 parts, Radix Aconiti Kusnezoffii 10 parts, Rhizoma Atractylodis 20 parts, Radix Clematidis 30 parts, Rhizoma Curculiginis 20 parts, the Radix Polygoni Multiflori 25 parts, Radix Astragali 30 parts, 30 parts, Poria.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.Such as these crude drug pulverize mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, make oral liquid; Also directly decoction can be taken if desired.

Medicine of the present invention has effect of expelling wind and cold, understand things pain-stopping, and short treating period is evident in efficacy, without any side effects, according to clinical 210 routine patient view statistics, take medicine of the present invention the obvious effective rate course for the treatment of 75.24%, two obvious effective rate 84.76%, three course for the treatment of obvious effective rates course for the treatment of 92.86%.

Detailed description of the invention

Take following each medicine:

10 parts, Herba Ephedrae, Herba Asari 10 parts, Radix Stephaniae Tetrandrae 25 parts, Rhizoma Smilacis Glabrae 25 parts, Pheretima 20 parts, Radix Achyranthis Bidentatae 20 parts, Radix Aconiti Kusnezoffii 10 parts, Rhizoma Atractylodis 20 parts, Radix Clematidis 30 parts, Rhizoma Curculiginis 20 parts, the Radix Polygoni Multiflori 25 parts, Radix Astragali 30 parts, 30 parts, Poria.

Said medicine is put in mortar successively and grinds well, cross 100 mesh sieves, then subpackage two pouch; When taking one day twice once a bag, 15 days is a course for the treatment of.

Here is the clinical data that patient uses medicine of the present invention:

One, physical data

Accept for medical treatment patient totally 210 example, make a definite diagnosis all on inspection, its age 22-39 year, average 33 years old.

Two, diagnostic criteria

1, arthralgia, can have tenderness, and activity is slightly limited, accidental limping.2, how normally, arthrocentesiS fluid inspection and cell culture can not find antibacterial, imaging examination visible joint hydrops for erythrocyte sedimentation rate, numeration of leukocyte, c reactive protein.

Three, Therapeutic Method

Patient takes medicine of the present invention, one day twice, once a bag.

Four, efficacy assessment standard

Effective: after terminating the course for the treatment of, clinical symptoms disappears completely.

Take a turn for the better: symptom is alleviated substantially.

Invalid: remission is not obvious.

Five, therapeutic outcome

Treatment time	Effective (example)	Obvious effective rate %	Take a turn for the better (example)	Improvement rate %	Invalid (example)	Inefficiency %
							One course for the treatment of	158	75.24	42	20.00	10	4.76
Two courses for the treatment of	178	84.76	24	11.44	8	3.80
							Three courses for the treatment of	195	92.86	10	4.76	5	2.38

Model case:

One, Mrs Li, 35 years old, From Shandong Rizhao people, arthralgia, had tenderness, and activity is slightly limited, and erythrocyte sedimentation rate, numeration of leukocyte, c reactive protein are normal, and arthrocentesiS fluid inspection and cell culture do not find antibacterial, CT examination visible joint hydrops.

After taking a course for the treatment of of medicine of the present invention, patient articular's pain relief, after continuing to take a course for the treatment of of medicine of the present invention, arthralgia disappears, without tenderness, check CT: hydrarthrosis disappearance, continue one the course for the treatment of consolidate curative effect.

Two, Wang man, 27 years old, Linchu, shantung people, arthralgia, had tenderness, and activity is slightly limited, accidental limping, and erythrocyte sedimentation rate, numeration of leukocyte, c reactive protein are normal, and arthrocentesiS fluid inspection and cell culture do not find antibacterial, and MRI checks visible joint hydrops.

After taking a course for the treatment of of medicine of the present invention, patient feels symptom and obviously alleviates, and arthralgia obviously alleviates, and tenderness disappears, and after continuing to take a course for the treatment of of medicine of the present invention, arthralgia stops, continuing one the course for the treatment of consolidate curative effect.

Claims (2)

1. treat the medicine of hydrarthrosis for one kind, it is characterized in that it is made up of the crude drug of following weight proportion: Herba Ephedrae 3-10 part, Herba Asari 2-10 part, Radix Stephaniae Tetrandrae 5-25 part, Rhizoma Smilacis Glabrae 15-60 part, Pheretima 5-20 part, Radix Achyranthis Bidentatae 5-20 part, Radix Aconiti Kusnezoffii 3-10 part, Rhizoma Atractylodis 5-20 part, Radix Clematidis 6-30 part, Rhizoma Curculiginis 3-20 part, Radix Polygoni Multiflori 9-25 part, Radix Astragali 30-60 part, Poria 10-30 part, said medicine is put in mortar successively and grinds well, cross 100 mesh sieves, then subpackage and get final product.

2. medicine according to claim 1, is characterized in that it is made up of the crude drug of following weight proportion:

10 parts, Herba Ephedrae, Herba Asari 10 parts, Radix Stephaniae Tetrandrae 25 parts, Rhizoma Smilacis Glabrae 25 parts, Pheretima 20 parts, Radix Achyranthis Bidentatae 20 parts, Radix Aconiti Kusnezoffii 10 parts, Rhizoma Atractylodis 20 parts, Radix Clematidis 30 parts, Rhizoma Curculiginis 20 parts, the Radix Polygoni Multiflori 25 parts, Radix Astragali 30 parts, 30 parts, Poria.