CN105434992A - Medicine for treating acute renal failure - Google Patents
Medicine for treating acute renal failure Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention relates to a medicine for treating the acute renal failure. The medicine is prepared from, by weight, 10 parts of rhubarb, 6 parts of gleditsia sinensis sting, 9 parts of Lepidium apetalum Willd., 9 parts of Ajuga forrestii Diels, 10 parts of Onychium contigum(Wall.)Hope, 6 parts of alpine clintonia, 9 parts of Orixa japonica Thunb., 6 parts of Cirsium pendulum Fisch.ex DC., 20 parts of coix seeds, 12 parts of Lissorhoptrus oryzophilus Kus and 6 parts of radix glycyrrhizae. The medicine has the advantages that rhubarb purges heat and relieves intestines, cools blood and removes toxin, and removes stasis and stimulates menstrual flow; gleditsia sinensis sting can stimulate meridian, promote qi and blood, and remove stasis; Lepidium apetalum Willd., Ajuga forrestii Diels and Onychium contigum(Wall.)Hope clear away heat and toxic materials, and induce diuresis for treating stranguria; alpine clintonia dispels wind and removes toxin, and removes stasis; Orixa japonica Thunb. clears away heat and promotes diuresis, and soothes nerves; Cirsium pendulum Fisch.ex DC. removes toxin and tonifying deficiency; coix seeds strengthen spleen and excrete dampness, remove numbness and stop diarrhea, and clear away heat and remove pus; Lissorhoptrus oryzophilus Kus relieves exterior syndromes and dispels cold, stimulates meridian, and induces urination; radix glycyrrhizae strengthens spleen and nourishes qi, clears away heat and toxic materials, expels phlegm to arrest coughing, relieves emergency and stops pain, and coordinates medicine actions; the medicine components are used in cooperation and play a role in clearing away heat and toxic materials, promoting blood circulation to remove stasis, and removing qi obstruction for diuresis; it is proved through clinical experiments that the medicine can safely and effectively treat the acute renal failure.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine being used for the treatment of acute renal failure.
Background technology
Acute renal failure, this disease is a kind of acute renal injury caused by Different types of etiopathogenises, nephron regulatory function can be made within a few hours to a couple of days sharply to go down, so that fluid electrolyte balance and excretion metabolism product can not be maintained, and cause hyperkalemia, metabolic acidosis and acute uremia syndrome, this syndrome is clinical is called acute renal failure.The acute renal failure of narrow sense refers to acute tubular necrosis.That a variety of causes causes acute oliguria or anuria, the discharge of nitrogenous metabolic waste sharply reduces, there is azotemia rapidly, water, electrolyte and acid base imbalance, and therefore there is the syndrome of the pathological changes such as a series of circulation, breathing, nerve, digestion, endocrine and metabolism, be called acute renal failure syndrome.
Though motherland's medical science is without the title of acute renal failure, from the difficulty in urination in traces in ancient times, in the syndrome doors such as obstruction and rejection, similar record can be found.The traditional Chinese medical science is thought, main, pyretic toxicity damp and hot with diseases caused by exogenous pathogenic factor and loss of thick fluid, Tianjin wound etc. relevant.Pathogenesis is not normal with the conduction of lung spleen kidney, internal organs pathological changes is relevant, wherein compromised kidneys, functioning of bladder malfunction, and it is that morbidity is crucial that water turbid damp heresy can not excrete.
Clinical manifestation
1. oliguria stage: mainly Nausea and vomiting, headache, dizziness, agitation, weak, drowsiness and stupor.Due to the accumulation of water, sodium in oliguria stage body, can there is hypertension, pulmonary edema and heart failure in patient.When the metabolite of protein through renal excretion, can not occur azotemia when causing nitrogen substance to gather in vivo.As simultaneously with infection, damage, heating, then protein catabolism is accelerated, and blood urea nitrogen, creatinine raise fast, namely form uremia.Reduce rapidly after urine volume idiopathy, every day is at below 400ml, but anuria person is rare completely, and the urine volume of some patients at 600-800ml or more, can be called non-oligouric acute renal failure.The short person 1-3d of oliguria stage, the tens of sky of elder, generally about 1-2 weeks, later urine volume increases gradually.
2. diuresis stage: mainly have a delicate constitution, malaise, cardiopalmus, tachypnea, become thin, anemia etc.In the oliguria later stage, urine volume increases gradually, reaches more than 500ml and namely enters to divide a word with a hyphen at the end of a line the stage, enter diuresis stage more than during 1000ml, though now urine volume increase uremia is still in peak.When urine volume increases to 1500-more than 2000ml, edema disappears gradually, and uremia and acidosis symptom alleviate thereupon, and blood pressure, blood urea nitrogen and creatinine also decline and be tending towards normal.Current period generally went through for 1-3 weeks, because reabsorption functional rehabilitation is comparatively slow, easily had dehydration between diuresis stage, loses sodium, lost potassium, occur corresponding symptom.The recovery of anemia and the disappearance of urine protein slower.Specific gravity of urine is often on the low side, and leukocyte can increase, and cast is sustainable exists several weeks.
3. convalescent period: because tissue consume is very large in the course of disease, measure according to nitrogen balance, for 3-June and begin to recover.The kidney of some patient has cortical necrosis in various degree and interstitial fibrosis, oliguria stage elder then damages heavier, glomerular filtration rate and function of concentration and dilution etc. can show to go down in a long time even can not be recovered completely, presents the performance of chronic renal insufficiency.
Diagnose this disease mainly rely on lab testing 1. sodium excretion secrete mark (FENa) or renal failure index (RFI) <1 and can indicate type azotemia before kidney more exactly, particularly for the patient of oliguria type, and the ARF of other reasons, especially ATN, then FENa or RFI higher (>2), these check that use is less in nonoliguric situation, even if but urine volume >500ml/d, FENa or RFI>2 still point out ATN.2. uroscopy: before kidney, the specific gravity of urine of property oliguria is high, more than 1.020, only accidental transparent and a small amount of granular cast in urine, and often have albumen, pigment and epithelial cell cast in renal tubular necrosis urine.Specific gravity of urine is below 1.016-1.018.3. blood test: blood urea nitrogen, creatinine, serum potassium concentration increase, is proportionate with the order of severity of disease; Serum sodium, chlorine, CO2 combining power, CO2 CP and acidity of blood all reduce.In diuresis stage, can there is low sodium, hypokalemia in blood biochemical.4. kidney biopsy: be worth greatly etiological diagnosis, can find various renal glomerular disease, ARF caused by tubulo-interstital pathological changes and Small vessel, can change the Treatment and diagnosis of 50% patient.5. renal ultrasonography: two kidney many anthorismas during ARF, renal cortex Echoenhance, aggregation system is separated, pelvic cavity or posterior wall of abdomen lump and lithangiuria, after kidney, property ARF can find to block under B ultrasonic, show as hydronephrosis, by Doppler technology, the ultrasonic blood circumstance that can also detect different blood vessel in kidney.
Drug therapy 1. vasodilation medicine as dopamine, phentolamine, papaverine; 2. diuretic, general furosemide heavily absorbs sodium to suppress renal tubules, alleviates the burden of thick section of ascending limb, increases urine volume and improves the circulation of kidney inner blood; 3. then give 25%-50% Glucose Liquid intravenous injection or instillation when not taking food, at least 100g/d is to prevent ketosis and to control into liquid measure.4. edema and blood sodium too low: add trunk offering liquid measure and control, useful 20%-25% mannitol of Severe edema or sorbitol 25-50g oral. every day 1-2 times is to produce laxativeness.5. treatment by Chinese herbs acute renal failure can use traditional Chinese medical herbal treatment, and effectiveness comparison is desirable.Should be careful in one's diet and living habit simultaneously.
Medical material involved in the present invention is recorded in all as seen " China's book on Chinese herbal medicine ".
Summary of the invention
The present invention aims to provide a kind of medicine being used for the treatment of acute renal failure, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing acute renal failure.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of medicine being used for the treatment of acute renal failure, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix Et Rhizoma Rhei 10 parts, Spina Gleditsiae 6 parts, hot food 9 parts, dysentery is grass 9 parts, ferrum foot grass 10 parts, Herba clintoniae udensis 6 parts, smelly Radix Dichroae 9 parts, smoke pipe Ji 6 parts, Semen Coicis 20 parts, Herba leerisae hexandrae 12 parts, 6 parts, Radix Glycyrrhizae only.
Below in conjunction with theories of Chinese materia medica, beneficial effect of the present invention is described:
Inventor thinks, the pathogenesis of acute renal failure mostly is " yang deficiency ", " pyretic toxicity " and " blood stasis ", has in wind-heat evil toxin and invades, the dirty functional disorder of lung spleen kidney three, functioning of bladder is not normal, caused by the operation of water liquid is obstructed, so treatment adopts heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, activating QI diuresis.
The present invention uses: Radix Et Rhizoma Rhei purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation; Spina Gleditsiae can the meridian dredging, qi and blood circulation promotion, and eliminating stagnation is become silted up; Hot food, dysentery is grass, ferrum foot grass heat-clearing and toxic substances removing only, inducing diuresis for treating stranguria syndrome; Herba clintoniae udensis dispels the wind and relieves internal heat, dissipating blood stasis; Smelly Radix Dichroae clearing away heat-damp and promoting diuresis, calms the nerves; Smoke pipe Ji removing toxic substances tonify deficiency; Semen Coicis spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away; Herba leerisae hexandrae induces sweat cold expelling, the meridian dredging, diuresis; Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.All medicines share, and play heat-clearing and toxic substances removing altogether, blood circulation promoting and blood stasis dispelling, the merit of activating QI diuresis.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor collects 80 routine patients with acute renal failures between 2010 06 month-2014 years 06 month altogether.Be divided at random: treatment group 40 example, matched group 40 example.Wherein treatment group man 21 example, female 19 example, 57.8 years old mean age; Matched group man 20 example, female 20 example, 56.3 years old mean age.The data there was no significant differences such as two groups of sexes, age, courses of disease, have comparability.
Diagnostic criteria
1. shock or intravascular hemolysis is had, drug intoxication or allergies;
2. in correction or after getting rid of acute hypovolemia, dehydration, urinary tract obstruction, urine volume still≤17/ml/h or urine volume still≤400/ml/24h;
3. specific gravity of urine is below 1.015, is even fixed on 1.010;
4. hurried generation and the azotemia that grows with each passing day;
5. routine urianlysis: urine opens (proportion 1.010 ~ 1.016) in waiting, albuminuria (be often+~ ++), Urine sediments analyzer often has granular cast, epithelial cells fragments, erythrocyte and leukocyte.Urine sodium > 40mmol/L;
6. prerenal azotemia, acute urinary tract obstruction, acute renal glomerulus illness, acute interstitial nephritis, acute kidney vascular disorder etc. must be got rid of before establishment diagnosis.
1. inclusive criteria meets diagnostic criteria; 2. 18 ~ 70 years old age; 3. compliance is good; 4. Informed Consent Form is signed voluntarily.
Exclusion standard is property oliguria and hepatorenal syndrome before kidney 1.; 2. the organ dysfunctions such as severe cardiac, liver, lung are merged; 3. before this research, 12H used loop diuretic or osmotic diuretic person; 4. pregnancy period or women breast-feeding their children.
2, Therapeutic Method
The oral dicycloverine (dicyclomine) of matched group, 20mg, 4 times/d; Dicetel, 50mg, 3 times/d; Oleum menthae 0.2ml.Treat 21 days.
Treatment group, on matched group basis, adds the capsule that the present invention obtains according to specific embodiment 3, every day 3 times.Treat 21 days.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
1. cure: clinical symptom disappearance, every day urine volume >1000 milliliter, blood, routine urinalysis and blood biochemistry index recover normal;
2. effective: clinical symptom disappearance, oliguria person urine volume >400 milliliter, renal function is clearly better, and blood, routine urinalysis and blood biochemistry index are comparatively before clearly better;
3. invalid: clinical symptoms and blood urea nitrogen, creatinine is without improvement or have deterioration person.
3.2 treatment statistical results are in table 1.
Table 1 liang group comparitive study
Visible, the medicine that the present invention obtains safe and effectively can be used for the treatment of acute renal failure, and cure rate significantly improves.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take: Radix Et Rhizoma Rhei 10 grams, Spina Gleditsiae 6 grams, hot food 9 grams, dysentery is grass 9 grams, ferrum foot grass 10 grams, Herba clintoniae udensis 6 grams, smelly Radix Dichroae 9 grams, smoke pipe Ji 6 grams, Semen Coicis 20 grams, Herba leerisae hexandrae 12 grams, 6 grams, Radix Glycyrrhizae only; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of acute renal failure.Oral, daily once.
Embodiment 2
Take: Radix Et Rhizoma Rhei 10 grams, Spina Gleditsiae 6 grams, hot food 9 grams, dysentery is grass 9 grams, ferrum foot grass 10 grams, Herba clintoniae udensis 6 grams, smelly Radix Dichroae 9 grams, smoke pipe Ji 6 grams, Semen Coicis 20 grams, Herba leerisae hexandrae 12 grams, 6 grams, Radix Glycyrrhizae only; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of acute renal failure.Oral, every bu is taken for twice sooner or later.
Embodiment 3
Take: Radix Et Rhizoma Rhei 10 grams, Spina Gleditsiae 6 grams, hot food 9 grams, dysentery is grass 9 grams, ferrum foot grass 10 grams, Herba clintoniae udensis 6 grams, smelly Radix Dichroae 9 grams, smoke pipe Ji 6 grams, Semen Coicis 20 grams, Herba leerisae hexandrae 12 grams, 6 grams, Radix Glycyrrhizae only; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of acute renal failure.Oral, every bu morning, noon and afternoon take for three times.
Claims (4)
1. one kind is used for the treatment of the medicine of acute renal failure, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix Et Rhizoma Rhei 10 parts, Spina Gleditsiae 6 parts, hot food 9 parts, dysentery is grass 9 parts, ferrum foot grass 10 parts, Herba clintoniae udensis 6 parts, smelly Radix Dichroae 9 parts, smoke pipe Ji 6 parts, Semen Coicis 20 parts, Herba leerisae hexandrae 12 parts, 6 parts, Radix Glycyrrhizae only.
2. a kind of medicine being used for the treatment of acute renal failure as claimed in claim 1, it is characterized in that, its preparation method is: take: Radix Et Rhizoma Rhei 10 parts, Spina Gleditsiae 6 parts, hot food 9 parts, dysentery is grass 9 parts, ferrum foot grass 10 parts, Herba clintoniae udensis 6 parts, smelly Radix Dichroae 9 parts, smoke pipe Ji 6 parts, Semen Coicis 20 parts, Herba leerisae hexandrae 12 parts, 6 parts, Radix Glycyrrhizae only; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. a kind of medicine being used for the treatment of acute renal failure as claimed in claim 1, it is characterized in that, its preparation method is: take: Radix Et Rhizoma Rhei 10 parts, Spina Gleditsiae 6 parts, hot food 9 parts, dysentery is grass 9 parts, ferrum foot grass 10 parts, Herba clintoniae udensis 6 parts, smelly Radix Dichroae 9 parts, smoke pipe Ji 6 parts, Semen Coicis 20 parts, Herba leerisae hexandrae 12 parts, 6 parts, Radix Glycyrrhizae only; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
4. a kind of medicine being used for the treatment of acute renal failure as claimed in claim 1, it is characterized in that, its preparation method is: take: Radix Et Rhizoma Rhei 10 parts, Spina Gleditsiae 6 parts, hot food 9 parts, dysentery is grass 9 parts, ferrum foot grass 10 parts, Herba clintoniae udensis 6 parts, smelly Radix Dichroae 9 parts, smoke pipe Ji 6 parts, Semen Coicis 20 parts, Herba leerisae hexandrae 12 parts, 6 parts, Radix Glycyrrhizae only; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
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| CN201610048380.5A CN105434992A (en) | 2016-01-25 | 2016-01-25 | Medicine for treating acute renal failure |
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| CN201610048380.5A CN105434992A (en) | 2016-01-25 | 2016-01-25 | Medicine for treating acute renal failure |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103417914A (en) * | 2013-07-30 | 2013-12-04 | 黄淮学院 | TCM composition for treatment of acute renal failure |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417914A (en) * | 2013-07-30 | 2013-12-04 | 黄淮学院 | TCM composition for treatment of acute renal failure |
Non-Patent Citations (2)
| Title |
|---|
| 武智: "《全国青年中医药论文荟萃 第1卷》", 31 August 1994, 中国医药科技出版社 * |
| 王明如: "大黄治疗急性肾功能衰竭", 《中医杂志》 * |
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