CN1723927A - Traditional Chinese medicine for treating urinary system infection - Google Patents

Abstract

A Chinese medicine for treating the acute infection of urinary system is prepared from 9 Chinese-medicinal materials including talc, scutllaria root, honeysuckle flower, rhubarb, liquorice root, etc.

Description

Treatment urinary system infection Chinese medicine

Technical field: the present invention relates to treat the medicine of urinary system infection, be specially a kind of treatment urinary system infection Chinese medicine.

Background technology: urinary system infection claims urinary tract infection (urinary tract infection) again, be meant pathogen growth and breeding in urine, especially escherichia coli in body, urinate in growth and breeding, and invade urinary tract mucosa or organize caused infection, it is a kind of commonly encountered diseases, frequently-occurring disease, and have intractable, delay property, healing time is long, the characteristics that relapse rate is high, in infectious disease, account for second, be only second to upper respiratory tract infection.According to domestic statistics, the urinary system infection patient accounts for China's generaI investigation statistics population 0.91%, and especially the women sees more, and about 2.37%.How disease preventing and treating is improved the quality of living, and is current people's question of common concern.At the urinary system infection cause of disease, doctor trained in Western medicine adopts antibacterial drug therapy more, although the mankind defeat " magical weapon " antibacterials of infectious disease to bring into play important function in the treatment of infectious disease, but a large amount of clinical datas show, the phenomenon of the clinical abuse of antibiotics of China is very general, and cause the rapidly ability that develops immunity to drugs of variation of antibacterial that causes, impel the appearance of novel antibacterial medicine of new generation, but the speed of developing new drug always can't be caught up with the speed of bacterial resistance, have suffered repeated defeats the history of fighing repeatedly after suffering repeated defeats thereby deduced.Therefore the appearance of Chinese medicine antibacterials is undoubtedly another the favourable weapon to anti-infectious disease.So it is strong to seek a kind of sterilizing power, oral absorption is good, and the medicine of the treatment urinary system infection that side effect is little is necessary especially.

Summary of the invention: the object of the present invention is to provide the shortcoming that a kind of compatibility is simple, with low cost, safe and reliable, easy to use, overcome heating extraction, at normal temperatures the treatment urinary system infection Chinese medicine of Bao Cuning.The object of the present invention is achieved like this: it comprises, and Talcum, Flos Lonicerae, Radix Scutellariae, Semen Plantaginis,  hold, Herba Dianthi, Herba Lophatheri, Radix Et Rhizoma Rhei, Radix Glycyrrhizae.Component by weight percentage, Talcum 380, Flos Lonicerae 380, Radix Scutellariae 250, Semen Plantaginis 250,  hold 250, Herba Dianthi 250, Herba Lophatheri 190, Radix Et Rhizoma Rhei 250, Radix Glycyrrhizae 250.Radix Scutellariae decocts with water twice with multi-function extractor, adding for the first time 8 times of water gagings decocted 2 hours, add for the second time 6 times of water gagings and decocted 1 hour, each decoction liquor filters merging filtrate with two layer of 300 order silk one deck absorbent cotton, transfer PH to 1.0-2.0 with 2mol/L HCl, and in 60-80 ℃ the insulation 1 hour after, abandoning supernatant after static 12 hours, the precipitation add 6-8 times of water gaging after, transfer PH to 7.0 with 40%NaOH again, add equivalent ethanol, filter, after filtrate is transferred PH2.0 with 2mol/L HCl, in 60 ℃ of insulations 30 minutes, static 12 hours, abandoning supernatant, precipitation is washed till PH to 7.0 with ethanol, wave most ethanol, promptly get baicalin, carry out drying, temperature is controlled at 80 ℃, 33% Pulvis Talci is broken into fine powder 80 orders in dry baicalin of gained and the prescription, and 80 orders that sieve are standby; Eight flavors such as all the other Flos Loniceraes add 10 times of water gagings and decoct secondary, each 1 hour, merge extractive liquid,, filter with two layer of 300 order silk one deck absorbent cotton, filtrate is evaporated to the clear paste of 1.38-1.40 (80 ℃) under 75 ℃, 0.085MPa, add the Radix Scutellariae fine powder, in 75 ℃ of dryings, pulverize 80 orders and become fine powder, mixing Chinese medicine; Incapsulate and be capsule formulation; Compacting is in blocks, and coating is a tablet form; Making granule is the granule dosage form.Advantage of the present invention is: compatibility is simple, with low cost, safe and reliable, easy to use, taking convenience, preserves at normal temperatures, is easy to carry about with one.

The specific embodiment: it comprises, and Talcum, Flos Lonicerae, Radix Scutellariae, Semen Plantaginis,  hold, Herba Dianthi, Herba Lophatheri, Radix Et Rhizoma Rhei, Radix Glycyrrhizae.Component by weight percentage, Talcum 380, Flos Lonicerae 380, Radix Scutellariae 250, Semen Plantaginis 250,  hold 950, Herba Dianthi 250, Herba Lophatheri 190, Radix Et Rhizoma Rhei 250, Radix Glycyrrhizae 250.Radix Scutellariae decocts with water twice with multi-function extractor, adding for the first time 8 times of water gagings decocted 2 hours, add for the second time 6 times of water gagings and decocted 1 hour, each decoction liquor filters merging filtrate with two layer of 300 order silk one deck absorbent cotton, transfer PH to 1.0-2.0 with 2mol/LHCl, and in 60-80 ℃ the insulation 1 hour after, abandoning supernatant after static 12 hours, the precipitation add 6-8 times of water gaging after, transfer PH to 7.0 with 40%NaOH again, add equivalent ethanol, filter, after filtrate is transferred PH2.0 with 2mol/L HCl, in 60 ℃ of insulations 30 minutes, static 12 hours, abandoning supernatant, precipitation is washed till PH to 7.0 with ethanol, wave most ethanol, promptly get baicalin, carry out drying, temperature is controlled at 80 ℃, 33% Pulvis Talci is broken into fine powder 80 orders in dry baicalin of gained and the prescription, and 80 orders that sieve are standby; Eight flavors such as all the other Flos Loniceraes add 10 times of water gagings and decoct secondary, each 1 hour, merge extractive liquid,, filter with two layer of 300 order silk one deck absorbent cotton, filtrate is evaporated to the clear paste of 1.38-1.40 (80 ℃) under 75 ℃, 0.085MPa, add the Radix Scutellariae fine powder, in 75 ℃ of dryings, pulverize 80 orders and become fine powder, mixing Chinese medicine; Incapsulate and be capsule formulation; Compacting is in blocks, and coating is a tablet form; Making granule is the granule dosage form.The present invention is a mildly bitter flavor, and is slightly sweet.Function of the present invention with cure mainly heat-clearing and toxic substances removing, relieving stranguria by diuresis.Be used for pyretic stranguria, disease is seen urine urgency-frequency, puckery pain when drowning, and it is not smooth to drench drop, and the urine color is muddy red, and lower abdomen is anxious full, red tongue, yellowish fur, rapid pulse.Be applicable to the acute urinary tract infection person that belongs to the damp-heat syndrome.

The present invention cures mainly card and is pyretic stranguria, is equivalent to the urinary tract infection of modern medicine.Its pathogenic factor mostly is the product of surfeit delicious food wine heat, so that accumulates humidogene heat, the damp and hot notes in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels; Or because of depressed rage impairing the liver, stagnated QI transforming into fire, or sexual life impairment caused by overstrain, moving in the asthenic fire, intimately tie mutually in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels with damp; Or experience the wind heat noxious dampness, and being condensed in part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels etc. and all can causing functioning of bladder unfavorable, urine leaching is puckery not smooth.Bright Li Zhongzi is at " Required Readings for Medical Professionals " medium cloud: " drench wet and hot two ends through speech by interior ... bladder heat is then puckery, and is several and puckery under water, then drench drop and do not declare, contraction in the lower abdomen, pain is drawn in umbilicus ".Bright Wang Kentang also cloud in " Standards of Diagnosis and Treatment ": " if eating and drinking without temperance, susceptible to anger frequently, deficiency and excess is uncomfortable, the internal organs discord causes and suffers from a deficiency of the kidney and bladder heat ... give and taste thinks of, gonorrhea must very be given birth to by heat and be wet, and then water liquid is muddy for humidogene, condenses and is pouring.Not only this also, the someone takes metal and stone medicine person, goes into the room too far, loses among the smart born of the same parents of inflow, and diet accumulation of phlegm infiltrator, then all becomes to drench "." case of horse training " more is loaded with: " pyretic toxicity closes the knot bladder, and what the urine drop was obstructed says ".Damp and hot amassing in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels must not be descending, and whether its urine desire to go or not, and do not go to come again, so frequent micturition, it is not smooth to drench drop.Accumulation of water with heat, functioning of bladder is unfavorable, so lower abdomen is anxious full; Damp-heat accumulation is not understood, and urine is decocted by it, so oliguria and muddy red; The red tongue with yellowish and greasy fur rapid pulse is damp and hot levying.Principle of treatment, when with heat-clearing and toxic substances removing, relieving stranguria by diuresis is main.The well-known doctor opened Bai Yu and once said modern age: " the stranguria initial stage, how true, belong to wet, belong to heat, should heat-clearing and toxic substances removing, blood stasis dispersing and deswelling, also quite effectively (" Zhanging uncle Yu case ") ".

Be monarch drug with Talcum, Flos Lonicerae among the present invention.The Talcum slightly sweet flavor is cold in nature, is good at clearing heat and freeing strangury, sliding diuresis key.Just claim it to control " difficulty in urination, diuresis " as far back as Shennong's Herbal." Mingyi Bielu " claims its " logical nine orifices six dirty body fluid, going or staying knot again." " medicine justice " cloud: " the sliding main diuresis of Talcum body, lightly seasoned master is oozed heat, can cleanse six internal organs and does not have the fraud that gram cuts down ".Flos Lonicerae sweet in the mouth cold nature is longer than heat-clearing and toxic substances removing." Chongqing hall random notes " call its " wind-fire is damp and hot in the clear network, separates the dirty filthy heresy of pestilence ".Essentials of Matea Medica " with five liang of Flos Loniceraes and Radix Glycyrrhizae one or two decoction, control that all are vicious, obey, then the efficacy of a drug to " to the intestine and small intestine tonneau.Radix Scutellariae in the side, Semen Plantaginis,  hold, Herba Dianthi is ministerial drug.Wherein the Radix Scutellariae bitter in the mouth is cold in nature, energy clearing away heat-fire, dampness detoxifcation." property of medicine opinion " called it and " controlled pyretic toxicity ... five types of stranguria "." the southern regions of the Yunnan Province book on Chinese herbal medicine " calls its " up purte the white, the descending bladder fire that rushes down is controlled man's five types of stranguria ".The Semen Plantaginis sweet in the mouth is cold in nature, and the energy clearing away heat and promoting diuresis is treating stranguria." Hunan medicine will " cloud its " damp-heat in the urinary bladder of dispelling, the blood detumescence of loosing ".It is cold in nature that  holds bitter in the mouth, can clearing heat and freeing strangury." the southern regions of the Yunnan Province book on Chinese herbal medicine " cloud " diuresis is controlled the five types of stranguria nebulousurine, pyretic stranguria "." book on Chinese herbal medicine justice " cloud: " letting out removing dampness heat with it, " so and control the puckery stranguria with turbid discharge of urinating.The Herba Dianthi bitter in the mouth is cold in nature, energy clearing away heat and promoting diuresis, removing blood stasis.Shennong's Herbal cloud: " all infirmity knots of main obstruction and rejection, urinary obstruction "." book on Chinese herbal medicine justice " cloud: " property is sliding sharp, and YIN-fire falls in the energy diuresis, removes five types of stranguria, sharp blood vessels ".More than four medicines, with monarch drug mutually 5, to strengthen heat-clearing and toxic substances removing, the merit of relieving stranguria by diuresis.With Herba Lophatheri, Radix Et Rhizoma Rhei, Radix Glycyrrhizae serves as that assistant makes, and the Folium Bambusae bitter in the mouth is cold in nature, and energy clearing away heat and promoting diuresis, and the sharp small intestinal that can clear away heart-fire draw damp and hot from urinating.The Radix Et Rhizoma Rhei bitter in the mouth is cold in nature, the poison that purges heat, and clots absorbing blood leads damp and hotly to go out from stool, matches with all medicines of diuretic, can draw to disappear damp and hot just the branch from two.And Shennong's Herbal cloud its " tonneau water anus "." Bencao Jingshu " is called that " damp and hot glue expectorant stagnates in the key medicine of the middle part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels." the Radix Glycyrrhizae sweet in the mouth is flat, can coordinating the actions of various ingredients in a prescription, relieving spasm to stop pain, detoxifcation is share with the relieving stranguria by diuresis medicine, can end pains in the penis, " collection of prescriptions with notes " cloud its " footpath reaches in the stem, and the Gan Nenghuan pain is also ".More than nine medicine compatibilities, play heat-clearing and toxic substances removing altogether, the merit of relieving stranguria by diuresis can be drawn damp and hot descendingly, just divides from two to disappear.

Quality standard control measure of the present invention: main medicine Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Radix Scutellariae differentiate that the result shows that 3 kinds of discrimination method specificities are strong among employing TLC method the other side, favorable reproducibility, the discriminating of suitable this product.When using in the high effective liquid chromatography for measuring preparation in the monarch drug Flos Lonicerae main component chlorogenic acid content, once consulted amount of literature data, mobile phase is selected, separating effect is better as a result.Because chlorogenic acid is subjected to thermally labile, consider that supersound extraction is easy and simple to handle, time is short, so when the preparation test liquid, select ultrasonic extracting method, and, 60min ultrasonic respectively 20,30,40,50 to same batch sample, behind the supersound extraction 30min, chlorogenic acid content promptly no longer increases as a result, so think that extracting 30min can extract fully; Serve as to extract solvent to extract with methanol, 50% methanol, 75% ethanol, water respectively to same batch sample simultaneously, the chlorogenic acid content of 50% methanol extraction sample is the highest as a result, so choose 50% methanol for extracting solution.Use direct mensuration of high performance liquid chromatography and secrete chlorogenic acid contents in the scorching recovering capsule, chlorogenic acid peak shape symmetry is separated fully, and collection of illustrative plates is simple, and method is easy, quick, and accuracy, precision height are as the quality control method of said preparation.

Stability test of the present invention: examine the relevant regulations requirement according to existing Pharmacopoeia of People's Republic of China, new Chinese medicine, carry out the preliminarily stabilised experiment, adopt the reserved sample observing method, finished product is packed in the packaging material, carry out stability experiment simultaneously to secreting scorching recovering capsule.Experiment showed, that this product is basicly stable in 6 months, meet and declare the clinical application requirement of experiment.

Pharmacodynamics of the present invention: extracorporeal bacteria inhibitor test proves, secreting scorching recovering capsule all has in various degree inhibitory action to escherichia coli, bacillus pyocyaneus, Bacillus proteus, staphylococcus aureus, aerobacteria, and its inhibitory potency all is better than the positive drug BAZHENG HEJI.The antibacterial mouse death rate that the lumbar injection escherichia coli are caused has tangible reduction effect in the body.Secreting the mouse ear rat toes swelling swollen and that Ovum Gallus domesticus album is caused that scorching recovering capsule oral administration administration xylol causes all has the obvious suppression effect, and is certain dose-effect relationship; Mice there is tangible diuresis; Rat temperature due to the yeast raise tangible antagonism.Proof is secreted scorching recovering capsule and is had antibacterial, antiinflammatory, diuresis, effect such as analgesic, for the clinical practice of this medicine provides experimental basis.

Acute toxicity test of the present invention: because this product is not measured LD ₅₀So, carry out maximum dosage-feeding and measure.The maximum dosage-feeding 34.4g/kg of this product is 502 times of clinical people's consumption, so think that this product oral medication is as safe as a house.

Long term toxicity test of the present invention: this medicine rat by 3.6,1.8 and three dosage groups of 0.9g/kg (content) gavage 90 days continuously, body weight, erythrocyte, hemoglobin, leukocyte, leukocyte differential count and the platelet counts of rat all do not had obvious change; Serum glutamic pyruvic transminase, glutamic oxaloacetic transaminase, GOT, blood urea nitrogen, creatinine (except that high dose group has obvious reduction), total protein, albumin, T-CHOL (except that high dose group has obvious reduction), alkali phosphatase, total bilirubin, glucose all there is not obvious influence.Important organ coefficient all in range of normal value, and is observed no obvious pathological change down through mirror.So think, this medicine is taken no obvious toxic and side effects for a long time being lower than under the above-mentioned dosage.

In sum, secrete scorching recovering capsule as object of study, its research is non-linear, and the present invention is from prescription development new Chinese medicine, after preparation is transformed, its composition certainty and maternal are distinguished to some extent, reach stable and controllable in the quality of the pharmaceutical preparations, after the acute and chronic toxicity test of animal confirms its safety, also will carry out pharmacodynamic index and verify that component difference causes the variation of new drug effectiveness, safety, and safety makes the patient be easy to accept.

Claims (2)

1, a kind of treatment urinary system infection Chinese medicine, it comprises that Talcum, Flos Lonicerae, Radix Scutellariae, Semen Plantaginis,  hold, Herba Dianthi, Herba Lophatheri, Radix Et Rhizoma Rhei, Radix Glycyrrhizae, it is characterized in that: component by weight percentage, Talcum 380, Flos Lonicerae 380, Radix Scutellariae 250, Semen Plantaginis 250,  hold 250, Herba Dianthi 250, Herba Lophatheri 190, Radix Et Rhizoma Rhei 250, Radix Glycyrrhizae 250.

2, a kind of treatment urinary system infection Chinese medicine according to claim 1, it is characterized in that: Radix Scutellariae decocts with water twice with multi-function extractor, adding for the first time 8 times of water gagings decocted 2 hours, adding for the second time 6 times of water gagings decocted 1 hour, each decoction liquor filters with two layer of 300 order silk one deck absorbent cotton, merging filtrate is transferred PH to 1.0-2.0 with 2mol/L HCl, and in 60-80 ℃ of insulation after 1 hour, abandoning supernatant after static 12 hours, after precipitation adds 6-8 times of water gaging, transfer PH to 7.0 with 40%NaOH again, add equivalent ethanol, filter, after filtrate is transferred PH2.0 with 2mol/L HCl, in 60 ℃ of insulations 30 minutes, static 12 hours, abandoning supernatant, precipitation is washed till PH to 7.0 with ethanol, waves most ethanol, promptly gets baicalin, carry out drying, temperature is controlled at 80 ℃, and 33% Pulvis Talci is broken into fine powder 80 orders in dry baicalin of gained and the prescription, and 80 orders that sieve are standby; Eight flavors such as all the other Flos Loniceraes add 10 times of water gagings and decoct secondary, each 1 hour, merge extractive liquid,, filter with two layer of 300 order silk one deck absorbent cotton, filtrate is evaporated to the clear paste that relative density is 1.38-1.40 (80 ℃ of heat is surveyed) under 75 ℃, 0.085MPa, add the Radix Scutellariae fine powder, in 75 ℃ of dryings, pulverize 80 orders and become fine powder, mixing Chinese medicine.