CN104324291A

CN104324291A - Traditional Chinese medicine preparation for treating large intestine damp-heat type hemafecia and preparation method of traditional Chinese medicine preparation

Info

Publication number: CN104324291A
Application number: CN201410655244.3A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Qingdao Hengbo Instrument Co Ltd
Priority date: 2014-11-17
Filing date: 2014-11-17
Publication date: 2015-02-04

Abstract

The invention provides a traditional Chinese medicine preparation for treating large intestine damp-heat type hemafecia. The traditional Chinese medicine preparation comprises the following raw material medicines in parts by weight: 10-20 parts of purslane, 10-20 parts of rhizoma smilacis glabrae, 10-20 parts of dandelion, 10-20 parts of Cyrtomium fortunei, 10-20 parts of sophora fruit, 10-20 parts of fructus forsythiae, 10-20 parts of honeysuckle, 10-20 parts of root of rehmannia, 10-20 parts of Polygonum cuspidatum, 10-20 parts of white paeony root, 10-20 parts of pericarpium granati, 10-20 parts of cortex phellodendri, 10-20 parts of the root of kudzu vine, 10-20 parts of radix angelicae, 10-20 parts of semen plantaginis and 10-20 parts of garden burnet. The traditional Chinese medicine preparation disclosed by the invention is used for treating large intestine damp-heat type hemafecia and is mainly used for treating internal burning pathogenic fire and invading blood. The traditional Chinese medicine preparation can effectively relieve large intestine damp-heat type diarrhea symptoms such as stomachache, diarrhea, tenesmus, burning pain in anus and hemafecia, has the effects of treating both symptoms and root causes and eliminating evil without damaging the essence and has unique advantages on patients who have antibiotic allergies and drug resistance and are inadaptable due to toxic and side effects.

Description

A kind ofly treat Chinese medicine preparation that Damp-heat syndrome has blood in stool and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant composition, particularly a kind ofly treating Chinese medicine preparation that Damp-heat syndrome has blood in stool and preparation method thereof.

Background technology

Blood is discharged from anus, stool band blood, or is hemafecia entirely, and color is scarlet, dark red or pitch sample, is all called and has blood in stool.Past occurs suddenly having blood in stool without anal and intestinal disease, or a small amount of dim red muddiness is had blood in stool and occured now and then, and does not prolongedly heal; Or with downright bad corrupt tissue, dense sexual secretion in having blood in stool, patient can not be careless and inadvertent, should go to examination in hospital.Have blood in stool and generally see lower digestive tract hemorrhage, particularly colon and rectum is hemorrhage, but visible upper gastrointestinal hemorrhage once in a while.Have blood in stool with skin, cat film or other organ hemorrhages phenomenon person, be more common in disease in the blood system and other systemic diseases.Having blood in stool is one of the cardinal symptom of digestive tract disease.One is the disease of intestinal itself, such as intestinal ulcer and inflammation, parasitic infection, tumor, hemorrhoid, intussusception, anal fissure, scratch etc. of being hard and dry.Two is the diseases of other system beyond intestinal, such as hematopathy, acute infectious disease, avitaminosis, poisoning or dealed with medicine went etc.

Sometimes because stool variable color can be caused after having eaten some food and medicine.Chalybeate, carbon dust, bismuth, the Chinese herbal medicine of having enriched blood as taken, or after having eaten the foods such as Hepar Sus domestica, animal blood, Fructus Lycopersici esculenti, Radix Betae, stool can be crineous, black or redness.Sometimes oral cavity or nasal cavity is hemorrhage swallow after also can cause stool color change.Be exactly false having blood in stool, stop using after medicine and food, " hemafecia " will disappear.Children's, if any black, kermesinus, jam or Semen Phaseoli soup sample feces, may be really have bleeding in esophagus, stomach, intestinal.If perianal intestinal wall bleeding due to trauma, then show as the feces surface that blood is attached to shaping.Also have child to have blood in stool, also usually have the symptoms such as stomachache, diarrhoea, heating, vomiting and systemic bleeding.To have blood in stool whether pain indication various disease: one, be common in without pain property fecal blood: 1. internal hemorrhoid feature is when having blood in stool, and color is scarlet in sound of rain pattering shape or spurting.In defecation or hemorrhage after an action of the bowels, due to matter hard feces galling mucosa, or too exert oneself because of during defecation, intravascular pressure increases, so that cirso-angiorrhexis causes bleeding to break and causes bleeding.2. rectum cancer induced hematochezia feature is that color is dark red, is often mixed with mucus and is attached to stool surface, often increase with times of defecation, the symptom such as anus bearing down.3. rectal polyp rectal polyp is had blood in stool and is common in minor, for blood, is placed on feces surface and does not mix with it.Can deviate from outside anus during the pedicle skin flap polypus defecation of rectum lower end.Two, painful fecal blood is common in: 1. tear or cutting pains when the anal fissure anal fissure feature of having blood in stool is defecation, and row's post-defecatory pain does not often continue dozens of minutes or several hours not etc.2. the inflammation of external hemorrhoid inflammation external hemorrhoid is had blood in stool, and there is swollen thing at conscious anus place, and pain, rectal tenesmus have a small amount of blood after defecation during tissue.Expectant treatment is identical with anal fissure demibain method, but had better operative treatment.3. cancer of anal canal patient obtained cancer of anal canal, oneself can find that anus has harder lump, in early days may be painless, can have pain late period and have blood in stool.The best Therapeutic Method of cancer of anal canal is operation.4. anal abscess or anus foreign body are when perianal plays pustule ulceration or has the foreign matters such as fish spicule in anal orifice, can cause infection, and with pain, have blood in stool.Now, must by operative treatment ability relief of symptoms.

The inspection item that needs of patients of having blood in stool does is exactly Rectal tonch.Rectal touch is a kind of reliable and easy method of Timeliness coverage rectal cancer.Have blood in stool and easily make to lose a large amount of ferrum in body, cause iron deficiency anemia.General development is slow, can not have in early days symptom or symptom slight, then there will be tachypnea, edema etc. after pale complexion, fatigue and weakness, inappetence, cardiopalmus, increased heart rate and physical exertion when anemia is heavier, some patients even can occur that neurological symptom is as emotional, excited, irritated etc.Have blood in stool also is the early signal of intestinal malignant tumor simultaneously, and because the situation of band blood is similar with bleeding hemorrhoids in just, common people are difficult to differentiation, add that some pay little attention to, primary malignant tumor is bred a tragedy by ignoring easily.

The harm of having blood in stool:

1. having blood in stool is the early signal of malignant intestinal tumor.The symptom of a lot of people to hemorrhoidal hemorrhage is familiar, so, as long as the symptom that occurs having blood in stool just takes it for granted that it oneself is suffered from hemorrhoid.But they do not know, having blood in stool also may be the early signal of intestinal malignant tumor.Clinically, have the early stage rectal neoplasm patient of 80%, all Zeng Yinwei ignorance is had blood in stool and the situation of Misdiagnosis occurs, thus incurs loss through delay the treatment of rectal neoplasm.

2. have blood in stool for a long time and can cause anemia.Have blood in stool for a long time, be easy to make human body lose a large amount of ferrum, cause iron deficiency anemia.The Anemia General development caused is slow, can not have in early days symptom or symptom slight; When Anemia is heavier, then there will be tachypnea, edema etc. after pale complexion, fatigue and weakness, inappetence, cardiopalmus, increased heart rate and physical exertion.

3. to have blood in stool the systemic-function that can affect the nerves.Have blood in stool and can also affect the nervous system of people, cause nerve system of human body dysfunction, thus some patients are occurred as the symptom such as passionnate, excited, irritated., have blood in stool for a long time meanwhile, patient also can be allowed to feel insecure all day, be absorbed in spirit frightened, have a strong impact on normal life and work.

4. have blood in stool and can cause septicemia, toxemia.Because what the anal and intestinal disease such as anal fissure, hemorrhoid caused has blood in stool, once cause infection, cause perianal abscess, bacteriotoxin, purulent core etc. are just easy to invade blood of human body, cause septicemia, toxemia etc.Long-term has blood in stool, and also may cause proctalgia, stool obstacle, bring lifelong misery to patient.

Have blood in stool, " Ling Shu Miraculous Pivot or Divine Axis all kinds of diseases and ailments begin raw " appellation: " rear blood "; Treatise on Febrile Diseases claims " hematochezia "; " Medical Treasures of the Golden Chamber " claims: " hematochezia ", and according to hematochezia and defecation priority, proposes the title of " bleeding from distant part " and " hematochezia ".Zhang Jingyue is pointed out: " the person that has come after an action of the bowels, it comes far away blood, farther or at small intestinal, or at kidney.。... .. blood before just the person that has come its come near, nearly person or at wide intestinal, or at anus." doctor's later age following color again pure and impure, vertical hemorrhoidal hamorrhage, the name of dysentery." key to Diagnosis and Treatment " cloud: " the scarlet person of serum color is hemorrhoidal hamorrhage, and turbid and dim person is dysentery." " Elementary Medicine " have blood in stool and namely go out strong, as the farther that arrow is penetrated, claim " spouting bleeding from anus ".This disease should be differentiated mutually with dysentery pus and blood.Dysentery pus and blood person, many assorted in pus and blood under, and have obvious stomachache, the performances such as tenesmus, the performance of this disease then for blood during stool under, and no pus sample thing, and without the obvious symptom such as stomachache and tenesmus.

Stool hematochezia, go out " Plain Questions negative and positive another matter ": by damp and hot, stagnant, knot poison invasion and attack the intestines and stomach, or wind, heat visitor in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, blood vessels damage caused by." Sanyin Ji Yi Bingzheng Fang Lun " rolls up nine: " patient defecates hematochezia, or clearly or turbid or fresh or black, or before just, or after an action of the bowels, or with let out thing and under ... therefore say and have blood in stool." " Medical Treasures of the Golden Chamber " take bleeding after defecation as bleeding from distant part, rectal bleeding followed by defecation is hematochezia.Hematochezia has dividing of hemorrhoidal hamorrhage, dysentery.Later age, from etiological classification, is divided into that hygropyretic hematochezia, pyretic hematochezia, hematochezia due to toxic heat, hematochezia due to noxious dampness, alcoholic hematochezia, invasion by pathogenic cold are had blood in stool, spouting bleeding from anus hematochezia, tuberculous peritonitis hematochezia etc., refers to each bar.To have blood in stool prolonged unhealed, how to be lost by visceral-qi, or prolonged illness liver is become homeless Tibetan, insufficiency of the spleenly can not take the photograph blood, suffer from a deficiency of the kidney can not admittedly lower caused by, controlling should righting, or eliminating evilly takes into account with righting.Dysentery is also shown in and has blood in stool.

" hemorrhoidal hamorrhage ", " dysentery " of the traditional Chinese medical science, " accumulation of YIN pathogens " three all refer to have blood in stool.Or rectal bleeding followed by defecation, or bleeding after defecation, or simple hematochezia." gold is deficient " has dividing of bleeding from distant part, hematochezia.Jing-Yue Complete Works illustrates bleeding from distant part further person, or at small intestinal, or at stomach; Hematochezia person, or at large intestine, or at anus." key to Diagnosis and Treatment ", with the clear and fresh person of color for hemorrhoidal hamorrhage, turbid and dim person is dysentery." Shengji Zonglu " calls knot person in cloudy gas is accumulation of YIN pathogens, and haemorrhoids is also included.Generally have blood in stool, pathogenesis has two, and one is insufficiency of the spleen blood of can not uniting, and two is damp invasion of lower energizer trauma large intestine yin collaterals.

The clinical disease such as typhoid fever, paratyphoid fever, acute gastroenteritis, hepatitis, biliary tract infection, bacillary dysentery, urinary system infection being common in modern medicine of traditional Chinese medical science damp-heat syndrome.The center of traditional Chinese medical science damp-heat syndrome is syndrome of dampness-heat of spleen and stomach, because taste are arranged in Jiao, spleen is for wet dirty, and stomach is dry internal organs, easily grows damp and hot heresy, on pathology with concealment, progressive, touching, repeatedly etc. for feature, can smoke upper and lower note, side reaches, network, inside and outside coupling, the interactive and witness of clinical easy appearance is waited, therapeutic process is " as oil enters face " often, inextricably involved.Damp-heat in the spleen and stomach bet large intestine then become syndrome of dampness-heat in large intestine, so syndrome of dampness-heat in large intestine and syndrome of dampness-heat of spleen and stomach closely related.Acute gastroenteritis should belong to the category of syndrome of dampness-heat in large intestine.Although the diagnostic criteria of tcm internal medicine association taste group and digestive system disease Professional Committee of combination of Chinese and Western medicine research association and each Education in TCM Higher Institutions is not the same, but syndrome of dampness-heat in middle jiao substantially all contains the following aspects content: 1. gastral cavilty or breast abdomen: feeling of fullness or distending pain or scorching hot: 2. thirsty or few drink or do not like drink or desire for hot drinks, bitter taste is dry or sticky; 3. defecate: half congealed and not well or have mucus; 4. tongue fur: yellowish and greasy fur, weight in wet base hot the lighter white and greasy fur or micro-Huang; Thermogravimetric wets the lighter's red tongue and yellow and greasy fur see; 5. body of the tongue: red or sharp limit is red; 6. pulse condition: moisten the slow or sliding number of number or stringy and rolling pulse.In addition, even the also minor symptom such as or indistinctive fever tired with heavy sensation of the body limb, indigestion and loss of appetite, nauseating, inappetence jaundice (being mostly YANG jaundice).Syndrome of dampness-heat in large intestine is with heating, large loose stool and not well or have mucus etc. for indispensable main clinic symptoms." the large opinion of Plain Questions YIN YANG classification of natural phenomena " order " wets and contains then watery diarrhea ", and " miscellaneous diseases source and course rhinoceros candle " day, " wetting and contain then lientery, was solely due to glue ear.Though do not know wind, cold, heat, void all can for sick, careless spleen is strong, and without wetting, four neither must in it, does He Zisheng rush down? ""Nei Jing" cloud: " spouting diarrhea with tenesmus all belongs to heat ".Damp-heat accumulation, puzzlement spleen soil, dysfunction of the spleen in transportation, dysfunction of the spleen in transportation and transformation, then clear QI being mixed up with turbid QI, water paddy mix and under, and walk large intestine and then become syndrome of dampness-heat in large intestine to have loose bowels.Viral escherichia coli (ETEC) are clinical common diarrhea inducing source of disease bacterium, along with antibiotic is applied in a large number widely, make the drug resistance which created in various degree, as the researchs such as Chen Yizhong find that ETEC also exists very general drug resistance, the strain of more than 7396 has drug resistance to the antibiotic that penicillin etc. four kinds is common, and multi-drug resistant is also on the rise, minimum opposing 9 kinds of medicines, the highest reaches more than 20 kinds ".And the drug resistance report of antibacterial to Chinese medicine compound is few, Chinese medicine has unique superiority as a kind of new Ceftriaxone cathartic thing.

Treatment have blood in stool and should distinguish cold and heat and asthenia and sthenia, as stool bleed or spurting hemorrhage, color is scarlet, red tongue, white and thin fur or BOHUANG, floating and rapid pulse, belong to discharging fresh blood stool, control and answer cooling blood, expelling wind to stop blooding, side's acupuncture and moxibusion is added and subtracted; Color of having blood in stool is fresh, and amount is many, and in anus, swollen thing is deviate from, burning sensation of the anus, or is just with pus and blood, and anus drops, lower abdomen dull pain, yellow and thin fur, wiry and frequent pulse, and card belongs to damp invasion of lower energizer, controls and answers heat clearing and damp drying to stop blooding, and side selects zanglian pills, zanglian wan to add and subtract.

Have blood in stool mostly recurrent exerbation, touching difficulty more, affect quality of life, causes sufferer psychology fear.Though most patient seeks medical advice in many ways, general all poor effect, cause anxiety, depression, and then further increase the weight of the state of an illness, have a strong impact on work and quality of life.

Summary of the invention

Technical problem to be solved by this invention is, it is common clinical that Damp-heat syndrome is had blood in stool, and doctor trained in Western medicine is conventional with antibiotic therapy.Antibiotic applies the appearance and toxicity that inevitably cause drug resistance repeatedly, and this has become problem demanding prompt solution clinically.For reducing antibiotic use, therapeutic modality best is at present the method adopting traditional Chinese medical science conditioning and treating.Have blood in stool and accompany by the five internal organs endogenous cause of ill body void and cause a disease.So should focus on during treatment to hold concurrently in anti-inflammation and sterilization to consolidate with tonify deficiency, to treating both the principal and secondary aspects of a disease.But the traditional Chinese medical science is particular about and is suited the remedy to the case, individual variation is obvious, will carry out, be unfavorable for that large-scale development is produced under the guidance of doctor.The present invention is directed to dirty under blood, the thick amount of matter is many, stool is smooth, the hot puckery Damp-heat syndrome of urine is had blood in stool; Prescription is flexible, except intestinal poison; Cure mainly in pathogenic fire vehement, the absurd row of forcing blood.Be good at hemorrhage in only intestinal, all medicines share, and effectively played sending down the abnormal ascending QI pathogenic fire purging, effect of purging FU-organs removing blood stasis makes to have blood in stool more.

For solving above-mentioned technical barrier, the invention provides a kind of Chinese medicine preparation for the treatment of Damp-heat syndrome and having blood in stool, the parts by weight of the crude drug of Chinese medicine preparation described in it can be: Herba Portulacae 10 ~ 20 parts, Rhizoma Smilacis Glabrae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Rhizoma Osmundae 10 ~ 20 parts, the Fructus Sophorae 10 ~ 20 parts, Fructus Forsythiae 10 ~ 20 parts, Flos Lonicerae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Pericarpium Granati 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Radix Sanguisorbae 10 ~ 20 parts.

The Chinese medicine preparation that described treatment Damp-heat syndrome is had blood in stool, the parts by weight of the crude drug of Chinese medicine preparation described in it can also be: Herba Portulacae 10 ~ 15 parts, Rhizoma Smilacis Glabrae 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts, Rhizoma Osmundae 10 ~ 15 parts, the Fructus Sophorae 10 ~ 15 parts, Fructus Forsythiae 10 ~ 15 parts, Flos Lonicerae 10 ~ 15 parts, 10 ~ 15 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Pericarpium Granati 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Radix Sanguisorbae 10 ~ 20 parts.

The Chinese medicine preparation that described treatment Damp-heat syndrome is had blood in stool, the parts by weight of the crude drug of Chinese medicine preparation described in it also can be: Herba Portulacae 10 ~ 20 parts, Rhizoma Smilacis Glabrae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Rhizoma Osmundae 10 ~ 20 parts, the Fructus Sophorae 10 ~ 20 parts, Fructus Forsythiae 10 ~ 20 parts, Flos Lonicerae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Pericarpium Granati 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Radix Sanguisorbae 10 ~ 20 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation that Damp-heat syndrome is had blood in stool, and the dosage form of preparation described in it is that the preparation process of tablet comprises:

A, getting crude drug and add hydro-thermal and extract 2 times, is component 1;

B, the medicinal residues extracted add ethanol extraction 2 times, are component 2;

C, above-mentioned two kinds of component extracts to be merged, after sterilization, add starch tabletting.

In described step a, can get crude drug and steep in water, soak more than 2 hours, add the water extraction 2 times of 8 times amount of crude drug gross weight, 6 times amount respectively, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, and one-tenth extractum, for component becomes 1.

In described step b, the medicinal residues of crude drug said extracted can crossed add ethanol, and add the ethanol warm macerating 2 times of 10 times amount of medicinal residues gross weight, 8 times amount respectively, the warm macerating time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merges 2 warm macerating liquid; Warm macerating liquid is evaporated to 1.25 extractum when density is 60 DEG C, and extractum is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes extractum, obtains component 2.

In described step c, can by component 1 and component also 2-in-1, then put into concentrating under reduced pressure tank, reclaim ethanol, be concentrated into the paste of when density is 80 DEG C 1.20, use oven drying powdered, after ultraviolet sterilization, add starch and be pressed into tablet.

For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method for the treatment of the Chinese medicine preparation that Damp-heat syndrome is had blood in stool, and the dosage form of preparation described in it is that the preparation process of enema comprises:

By described crude drug roguing, be ground into granule, soak 2 hours; Soaked raw material is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds up the water of medical material 7 times amount, decocts 1 ~ 1.5 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator and is condensed into pasty state.

Step filtrate be condensed in above-mentioned steps is: can get the mixing of twice decocting liquid, filter, the filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 90 DEG C, density is the extractum of 1.20, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, extractum is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, fill after ultraviolet sterilization.

The Chinese medicine preparation that described treatment Damp-heat syndrome is had blood in stool, the dosage form of Chinese medicine preparation described in it can be: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, dissolved granule, pill, powder, sublimed preparation, enema or injection.

The present invention treats damp-heat in the large intestine pattern of syndrome and has blood in stool, and this side cures mainly in pathogenic fire vehement, the absurd row of forcing blood.Flos Lonicerae heat-clearing and toxic substances removing in side of the present invention, this medicine also has the merit of astringing to arrest diarrhea, and to diarrhea due to damp-heat person, available clearing away heat to stop diarrhea is the key medicine that treatment damp-heat in the large intestine is had loose bowels; Semen Plantaginis heat clearing and damp drying, kind clearing liver-gallbladder, damp-heat in the spleen and stomach and diuresis, be all key medicine with Flos Lonicerae; The spleen invigorating of Cortex Phellodendri clearing heat and expelling damp, Semen Plantaginis clearing away heat-damp and promoting diuresis, treating diarrhea by diuretics, Radix Scutellariae heat clearing and damp drying, clear large intestine channel damp and hot, Fructus Forsythiae heat-clearing and toxic substances removing is key medicine altogether; Rhizoma Smilacis Glabrae circulation of qi promoting removing dampness intestinal stasis relieving is adjuvant drug; Herba Taraxaci rushes down clearly three burnt pathogenic heats, for making medicine.All medicines share, and play clearing heat and expelling damp altogether, the effect of eliminating fire and detoxication.Damp-heat syndrome the has loose bowels symptom such as the present invention effectively can alleviate stomachache, diarrhoea, tenesmus, burning sensation of the anus, have blood in stool, there is eliminating evil merit of not hindering positive treating both the principal and secondary aspects of a disease, therapeutic effect uses more merely GEGEN CENLIAN JIAONANG effective, and, drug resistance irritated for antibiotic and there is unique advantage because of the immalleable patient of toxic and side effects.

Detailed description of the invention

During defecation, stool band blood is the disease performance of various diseases, and coverage is extensive. clinical diagnosis and treatment must be combined with dialectical pivot in differential diagnosis of diseases.Chinese medicine thinks that generation not outer deficiency and excess two class of having blood in stool, excess syndrome are compel in wind-fire, damp and hotly accumulates steaming, bleeding due to blood-heat, and injury of blood collaterals by heat is for suffering from.Deficiency syndrome are blood deficiency dryness of the intestine, hyperactivity of fire caused by deficiency of YIN, and burn blood network or failure of the spleen to keep the blood flowing within the vessels, caused by QI failing to control blood.Damp invasion of lower energizer stool hematochezia as spattered, color as clear in matter is fresh, feverish sensation in the palms and soles, dry mouth and throat person, belong to invasion of the large intestine by heat, injure blood network, should cooling blood for hemostasis method.

" Ling Shu Miraculous Pivot or Divine Axis all kinds of diseases and ailments begin raw " appellation: " rear blood "; Treatise on Febrile Diseases claims " hematochezia "; " Medical Treasures of the Golden Chamber " claims: " hematochezia ", and according to hematochezia and defecation priority, proposes the title of " bleeding from distant part " and " hematochezia ".Zhang Jingyue is pointed out: " the person that has come after an action of the bowels, it comes far away blood, farther or at small intestinal, or at kidney.。... .. blood before just the person that has come its come near, nearly person or at wide intestinal, or at anus." doctor's later age following color again pure and impure, vertical hemorrhoidal hamorrhage, the name of dysentery." key to Diagnosis and Treatment " cloud: " the scarlet person of serum color is hemorrhoidal hamorrhage, and turbid and dim person is dysentery." " Elementary Medicine " have blood in stool and namely go out strong, as the farther that arrow is penetrated, claim " spouting bleeding from anus ".This disease should be differentiated mutually with dysentery pus and blood.Dysentery pus and blood person, many assorted in pus and blood under, and have obvious stomachache, the performances such as tenesmus, the performance of this disease then for blood during stool under, and no pus sample thing, and without the obvious symptom such as stomachache and tenesmus.Gastrointestinal is damp and hot: stool hematochezia, double see one's lips are dry and one's mouth parched, thirst and liking cold drink, gingivitis, halitosis bitter taste, aphtha of the mouth and tongue, constipation, burning sensation of the anus, red tongue with yellow fur, rapid pulse effectively wait disease.

Chinese medicine is thought, what damp-heat in the large intestine caused have blood in stool, and the four seasons are all visible, but are many with summer and autumn, are common, frequently-occurring disease.Many heresies damp and hot because of diseases caused by exogenous pathogenic factor, invasion and attack large intestine; Or because of eating and drinking without temperance (clean), retention of damp-heat in the interior, hinders in large intestine, conduction is neglected one's duty and causes.Its basic pathogenesis is damp-heat accumulation large intestine, QI and blood being obstructed, conduction dereliction of duty.Therefore see heating, stomachache, diarrhoea, tenesmus; Damp and hot smoked bright, heat corruption is pus, then burning sensation of the anus, stool containing pus and blood, oliguria with reddish urine; Yellow and greasy fur, slippery and rapid pulse are damp and hot resembling.Therefore clearing heat and expelling damp, removing toxic substances pathogenic fire purging is the main method for the treatment of of (Damp-heat syndrome) of having loose bowels.Flos Lonicerae heat-clearing and toxic substances removing in side of the present invention, this medicine of the author's clinical experience also has the merit of astringing to arrest diarrhea, and to diarrhea due to damp-heat person, available clearing away heat to stop diarrhea is the key medicine that treatment damp-heat in the large intestine is had loose bowels; Semen Plantaginis heat clearing and damp drying, kind clearing liver-gallbladder, damp-heat in the spleen and stomach and diuresis, be all key medicine with Flos Lonicerae; The spleen invigorating of Cortex Phellodendri clearing heat and expelling damp, Semen Plantaginis clearing away heat-damp and promoting diuresis, treating diarrhea by diuretics, Radix Scutellariae heat clearing and damp drying, clear large intestine channel damp and hot, Fructus Forsythiae heat-clearing and toxic substances removing is key medicine altogether; Rhizoma Smilacis Glabrae circulation of qi promoting removing dampness intestinal stasis relieving is adjuvant drug; Herba Taraxaci rushes down clearly three burnt pathogenic heats, for making medicine.All medicines share, and play clearing heat and expelling damp altogether, the effect of eliminating fire and detoxication.

This observation shows, Damp-heat syndrome the has loose bowels symptom such as the present invention effectively can alleviate stomachache, diarrhoea, tenesmus, burning sensation of the anus, have blood in stool, there is eliminating evil merit of not hindering positive treating both the principal and secondary aspects of a disease, therapeutic effect uses more merely GEGEN CENLIAN JIAONANG effective, and, drug resistance irritated for antibiotic and there is unique advantage because of the immalleable patient of toxic and side effects.

Radix Sanguisorbae picric acid; Cold; Nontoxic, Gui Jing: liver; Lung; Kidney; Large intestine channel.Effect: cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.Hemorrhage; Blood-cooling hemostatic.Cure mainly: spit blood, spitting of blood, epistaxis, hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting." detailed outline ": Radix Sanguisorbae, except part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels heat, controls defecation blood disorder.Hemostasis, get and cut off sheet and fry use, its tip then can promoting the circulation of blood, can not know.Yang Shiying cloud: all skin ulcer pain persons add Radix Sanguisorbae, and the person of itching adds Radix Scutellariae." book on Chinese herbal medicine is looked for the truth ": Radix Sanguisorbae, all books are all sayed because of its bitter cold, then can enter part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels blood system heat extraction, know from lower solution in order to do heat.Yan Xingchen and puckery again, ordinary person's disease suffering from, tells the diseases such as nosebleed metrorrhagia hemorrhoidal hamorrhage dysentery, obtains this and then can not understand by puckery blood.By this not without not tally, Ju knows that its heat is not removed, then blood is more than, and its heat is both clear, then blood is from peace, and the main convergence of its property, can fall clearly, again can astringent therapy, then do not consider clearly it and cross and let out, puckery also do not consider itself or stagnant, the antipyretic hemorrhage of strength is also.

Herba Taraxaci is the Chinese medicine commonly used simply, and its medical value is loaded various medical book early.Its all herbal medicine, containing compositions such as taraxasterol, taraxerol, taraxacin, caffeic acid, choline, inulin.The flat sweet and slightly bitter taste of property.Can heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Compendium of Material Medica is recorded: " heat clearing away poison, relieving dyspepsia poison, disappearing, evil is swollen, tuberculosis, furuncle are swollen for Detoxicating food-poisoning, loose stagnant gas." Herba Taraxaci hides sweet flat, its property is nontoxic.When being enter stomach into liver, the key medicine of antipyretic removing heat from blood.

Herba Portulacae: cold in nature, sweet in the mouth acid; Enter the heart, liver, spleen, large intestine channel.Effect: heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, hemostasis removing heat from blood.Cure mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia, had blood in stool, the diseases such as mastitis.Loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property." Kaibao Bencao ": " clothes not white all the year round.Control carbuncle skin ulcer, kill parasites.Raw juice of smashing takes, and when disliking thing under profit, removes tapeworm." Compendium of Material Medica: " loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property.”

Rhizoma Smilacis Glabrae is sweet light, flat.Gui Jing: Liver Channel; Stomach warp; Spleen channel.Function: removing toxic substances, dehumidifying, sharp joint.Cure mainly: control syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, treat furuncle, carbuncle, scrofula, syphilis and the limbs contracture caused by mercurialism, bones and muscles pain." book on Chinese herbal medicine justice ": Rhizoma Smilacis Glabrae, dampness removing reduces phlegm and internal heat, and can enter network, searches to pick and damp and hot accumulates poison.It separates d hydrargyrum, Calomelas poison person, and it is up that receive poison with ascending, and this leads as business under oozing profit, therefore specially control Fructus Myricae rubrae skin infection, gos deep into hundred networks, arthralgia, even rotten, and poison fire is up again, and throat pain is burst, and all dislike disease.

Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency." Bencao Jingshu ": Cortex Phellodendri, stagnation of pathogenic heat in main the five internal organs the intestines and stomach.Lid deficiency of YIN, then heat begins to tie in the intestines and stomach; Though jaundice is by damp and hot, the people in kidney-YIN being deficient so must be sent out; Perianal abscess is leaked, also caused by all damp and hot blood trouble; Let out dysentery person, dysentery also, the also damp and hot disease offending the intestines and stomach; Woman's whitish metrorrhagia, acute vulva ulcer, all damp and hot deficiency of YIN stream visitor bottom of taking advantage of forms; Red of skin heat, the hot swelling pain aphtha of order, all YinXuXueRe disease of viscera connecting with this channel also.With the gas of Zhiyin, mend the deficiency of Zhiyin, deficiency syndrome should be treated by tonifying method, with class from, therefore cloudy backheat solution, wet dry and all card oneself remove.Be the key medicine of kidney meridian, specially control all cards of the raw interior-heat of bright void, achievements very big, very medicine is also comparable.

Semen Plantaginis is sweet; Light; Cold nature.Gui Jing: return lung meridian; Liver Channel; Kidney channel; Urinary bladder channel.Function: clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Improving eyesight; Eliminate the phlegm.Cure mainly: main dysuria; Stranguria with turbid discharge leukorrhagia; Edema distension; Heat-damp in summer dysentery; Conjunctival congestion is hidden from view; Expectorant heat syndrome cough is breathed heavily.Collective Notes to the Canon of Materia medica: main asthenia." property of medicine is fallen ": can remove pathogenic wind toxic, the liver affected by pathogenic wind heat, malicious wind dotting punch order, swelling pain is hidden from view, and headache lacrimation, removes irritable feverish sensation of chest and heart." Japan hanako materia medica ": diuresis drenches puckery, tonifying YANG.Control de-essence, vexed.The therapeutic method to keep the adverse QI flowing downwards.

Rhizoma Osmundae is bitter, is slightly cold.Slightly poisonous.Return liver, spleen channel.Effect: heat-clearing and toxic substances removing, cooling blood for hemostasis, parasite killing.Anemopyretic cold, maculae caused by violent heat pathogen.This product bitter cold, can the excess-heat that divides of clearing heat in QI system, and have the pyretic toxicity separating blood system, the evil caused card of all warm poison all with it, often can be equal to use with Rhizoma Coptidis, Folium Isatidis, Radix Glycyrrhizae, as Rhizoma Osmundae falls apart (" Prescriptions for Universal Relief ").Single product or join Folium Mori, Flos Lonicerae etc. and can prevent and treat anemopyretic cold; If with compatibilities such as Radix Isatidis, Folium Isatidis, Radix Arnebiae (Radix Lithospermi)s, can be used for again the diseases such as mumps, maculae caused by violent heat pathogen, dermexanthesis.Heat in blood is hemorrhage.This product bitter in the mouth is slightly cold, main enter Liver Channel, have the merit of cooling blood for hemostasis, cure mainly the caused epistaxis of heat in blood, spit blood, have blood in stool, the disease such as metrorrhagia, be especially apt to control metrostaxis.As " Bencao Tujing " controls epistaxis, can grind into powder and be taken after mixing with liquid by single; If associate with Rhizoma Coptidis, grind sticky rice drink into powder and be taken after mixing with liquid, can haematemesis be controlled, as Rhizoma Osmundae loose (" Shengji Zonglu "); Treating hematochezia can compatibility Cacumen Platycladi; Controlling metrostaxis can with Oletum Trogopterori with using.

Fructus Forsythiae: the Fructus Forsythiae pharmacological action such as have antibacterial, heart tonifying, diuresis, town to tell, the diseases such as the conventional acute anemopyretic cold of forsythia fruit for treating, carbuncle sore tumefacting virus, tuberculous lymphadenitis, urinary tract infection are the primary raw material of the Chinese medicine preparation such as SHUANGHUANGLIAN KOUFUYE, SHUANGHUANGLIAN FENZHENJI, QINGRE JIEDU KOUFUYE, even careless antipyretic oral liquid, flos ionicerae and fructus forsythiae infusion for detoxication.Attribute: bitter, is slightly cold.Return lung, the heart, gallbladder meridian.Fructus Forsythiae has broad-spectrum antibacterial action, has very strong inhibitory action to staphylococcus aureus, Hayes dysentery bacterium, has certain inhibitory action to other pathogenic bacterium, influenza virus, fungus.There is antiinflammatory action.Oleanolic acid contained by this product has heart tonifying, diuresis and hypotensive activity, and Citrin can reduce vascular permeability and fragility, prevents haemolysis.Decoct has the town effect of telling, anti-liver injury effect.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.Cure mainly carbuncle sore tumefacting virus, sucutaneous nodule scrofula, affection due to external wind and heat, epidemic febrile disease is from the beginning of, puckery pain of pyretic stranguria etc.

Pericarpium Granati astringing intestine to stop diarrhea, hemostasis, anthelmintic.Control chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis, spermatorrhea, metrorrhagia, leukorrhagia, abdominal pain due to worm stagnation, scabies.Property of medicine opinion ": " control muscles and bones wind, waist foot is unsuccessful, the anxious pain of walking contraction.Main astringing intestine to stop diarrhea, only red white dysentery.Under extracting juice stops order tear, control Lou essence." supplement to the Herbal: " main ascarid.Decoction." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " controls with the passing of time watery diarrhea, simmering clothes, controlling again dysentery pus and blood, large intestine hematochezia with frying Saccharum Sinensis Roxb.." " is decocted with Fructus Aristolochiae and is controlled children's's infantile malnutrition worm." " book on Chinese herbal medicine covers bamboo fish trap ": " reason dental caries." " detailed outline ": " antidiarrheal dysentery, hematochezia, proctoptosis, metrorrhagia leukorrhagia.

Radix Puerariae induces sweat and brings down a fever, and promotes the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, to have loose bowels.Compendium of Material Medica is carried: Radix Puerariae, and cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling.Modern medicine study shows: the isoflavonoid puerarin in Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.Herba Gelsemii Elegantis has extraordinary curative effect to hypertension, hyperlipidemia, hyperglycemia, senile osteoporosis.Common people can select Drug therapy, due to side effects of pharmaceutical drugs and Drug resistance, withdraw rear blood pressure and rebound very soon.First Herba Gelsemii Elegantis food be as food, without any side effect, can play the object of conditioning, and can eat for a long time while allaying one's hunger.Also containing abundant trace element and aminoacid in Herba Gelsemii Elegantis, be kind of a rare green health care food, there is high nutritive value.

Flos Lonicerae: medical material Flos Lonicerae is Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or is with the flower just opened.Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.Its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.

Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping." Japan hanako materia medica ": control conjunctival congestion bulbar conjunctiva polyp, and tire patching leaks landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, goes face Shao-defect scar.

The Fructus Sophorae has good medical value, and long-term drink can control hemorrhoid by reducing blood pressure and blood fat bowel relieving fire, also has vessel softening, cholesterol reducing, dispelling wind heat, profit large intestine, effect of removing heat from blood relieving constipation.Ambition is unhappy, and conjunctival congestion is shed tears, and dizzy for falling person, normal this tea of drink is quite helpful.Carry according to " herbal classic ", in Fructus Sophorae master five, pathogen heat, only saliva and spittle, mend and hinder absolutely, five hemorrhoid, burn, and married woman's breast abdominal mass, son hides shoot.Supplement to the Herbal carries its parasite killing and removes wind, and improving eyesight is except hot tears, and between brains ambition, hot blast is unhappy, and dizziness due to wind pathogen is for falling, and salivation is as liquor-saturated in mind, ripples as person on ship car." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries its styptic powder cellulitis.Control five hemorrhoid discharging fresh blood stools, red white heat dysentery disease." about can cure mirror " carry its clear away heart-fire, lung, spleen, liver, large intestine fire.Control trusted subordinate's burning pain." book on Chinese herbal medicine asks former " is carried its Fructus Sophorae profit liver and is nourished blood.Control infantile malnutrition, furuncle, dysentery, collapse blood; Nucleon in its angle, supplementing the brain, parasite killing.

The Radix Rehmanniae: the Radix Rehmanniae is also Radix Rehmanniae, the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch..Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; The effect of Radix Rehmanniae and the Radix Rehmanniae is different.Radix Rehmanniae clearing away heat and promoting production of body fluid, can stop blooding and removing heat from blood, is often for consumption of YIN caused by febrile disease, the diseases such as haematemesis, laryngopharynx swelling and pain, crimson tongue excessive thirst, a speckle dermexanthesis and nosebleed heat.Relative to Radix Rehmanniae, the Radix Rehmanniae is heat clearing and blood cooling, also can promote the production of body fluid, all right yin nourishing, is used for treatment yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, crimson tongue excessive thirst, sends out the problems such as speckle dermexanthesis.The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.Not only promoting the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect to metrorrhagia, menoxenia, frequent fetal movement, constipation etc., every blood system has the people of thermal burn the moon, can often take.If want to treat epidemic febrile disease, qingying decoction can be done with the Radix Rehmanniae; If the later stage for the treatment of epidemic febrile disease, because waste heat does not also disappear to the greatest extent, the Radix Rehmanniae should be used for boiling QINGHAOBIEJIATANG; In addition, contain for heat in blood poison, macule purple is black, and the serious heat of epidemic febrile disease enters the symptom of nutrient blood, can take the Sisheng Wan that the Radix Rehmanniae is made; General want YIN nourishing and the production of body fluid promoting to treat interior-heat quenches one's thirst with constipation, the once liquid soup that the Radix Rehmanniae boils should be eaten.

The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Return liver, gallbladder, lung meridian.Function with cure mainly heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, postnatal blood stasis does not Xia ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, traumatic injury, carbuncle sore tumefacting virus.Huzhang effect, has obvious anastalsis to traumatic hemorrhage, and for oral administration also have anastalsis to upper gastrointestinal hemorrhage." Japan hanako materia medica ": after managing property stagnant blood not under, trusted subordinate's distension.Evacuation of pus, main furuncle carbuncle poison, married woman's bruise, flutters damage blood stasis, broken pathogenic wind toxic stagnation of QI." the southern regions of the Yunnan Province book on Chinese herbal medicine ": attack all toxic swellings, only have sore throat, diuresis, walk meridians.Control five types of stranguria nebulousurine, anal fistula, carbuncle sore, married woman's leucorrhea with red and white discharge.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, and spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, repercussive blood, can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, brings down a fever, relieving restlessness, QI invigorating, the capable hot disease in sky, pestilence miasma, mania and irritation, and married woman's blood is transported, and hemorrhoidal hamorrhage, rushes down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion exerts meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Specific implementation method:

The preparation method of capsule of the present invention: get Herba Portulacae 1500g, Rhizoma Smilacis Glabrae 1500g, Herba Taraxaci 1500g, Rhizoma Osmundae 1500g, Fructus Sophorae 1500g, Fructus Forsythiae 1500g, Flos Lonicerae 1500g, Radix Rehmanniae 1500g, Rhizoma Polygoni Cuspidati 1500g, Radix Paeoniae Alba 1500g, Pericarpium Granati 1500g, Cortex Phellodendri 1500g, Radix Puerariae 1500g, Radix Angelicae Dahuricae 1500g, Semen Plantaginis 1500g, Radix Sanguisorbae 1500g, is cut into coarse grain, to be then soaked in ethanol 2 hours.Then heating extraction 2 times, each 1-2 hour, merge extractive liquid, remove supernatant after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, becomes component 1.The medicinal residues of the crude drug crossed by above-mentioned ethanol extraction again add 10 times of water gagings, heating and refluxing extraction 2 times, each 1 ~ 2 hour, merged by 2 extracting solution and leave standstill, remove supernatant, then 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, becomes component 2.By the merging of component 1 and component 2, then put into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate, after the macroporous adsorptive resins absorption that volume is 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then is used 95% ethanol elution of 5 times of resin column volumes, is collected ethanol elution, remove solvent, obtain medicated powder.Incapsulate Chinese patent medicine.

The preparation method of the present invention's honey refining pill: get Herba Portulacae 1200g, Rhizoma Smilacis Glabrae 1300g, Herba Taraxaci 1200g, Rhizoma Osmundae 1100g, Fructus Sophorae 1200g, Fructus Forsythiae 1100g, Flos Lonicerae 1200g, Radix Rehmanniae 1200g, Rhizoma Polygoni Cuspidati 1200g, Radix Paeoniae Alba 1200g, Pericarpium Granati 1100g, Cortex Phellodendri 1200g, Radix Puerariae 1200g, Radix Angelicae Dahuricae 1200g, Semen Plantaginis 1200g, Radix Sanguisorbae 1200g, getting crude drug steeps in ethanol, soak more than 2 hours, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, supernatant is removed after leaving standstill, then concentrating under reduced pressure tank is put into, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the density of filtrate is 20 DEG C 1.06 extractum, become component and become component 1.The medicinal residues of the crude drug crossed by above-mentioned ethanol extraction add water, and then put into extraction pot heated and boiled 1 hour, and filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, heated and boiled half an hour third time, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, and filtered through gauze, is settled into extractum, becomes component 2.Merged by the extractum of component 1 and component 2, then put into concentrating under reduced pressure tank, reclaim ethanol, being concentrated into density is 1.20, and the pasty state of temperature to 80 DEG C-90 DEG C, with oven drying, powdered, adds Mel and be twisted into pill.

The preparation method of enema of the present invention is: get Herba Portulacae 1300g, Rhizoma Smilacis Glabrae 1300g, Herba Taraxaci 1200g, Rhizoma Osmundae 1100g, Fructus Sophorae 1200g, Fructus Forsythiae 1100g, Flos Lonicerae 1200g, Radix Rehmanniae 1200g, Rhizoma Polygoni Cuspidati 1200g, Radix Paeoniae Alba 1200g, Pericarpium Granati 1100g, Cortex Phellodendri 1200g, Radix Puerariae 1200g, Radix Angelicae Dahuricae 1200g, Semen Plantaginis 1200g, Radix Sanguisorbae 1200g, by described crude drug roguing, dry, be ground into granule, soak 1 hour; Soaked raw material is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, and get twice decocting liquid mixing, filtration, inserts the filtrate of filtration in economic benefits and social benefits vacuum concentrator, and when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, direct powdered.By fill after the filtrate ultraviolet radiation for sterilizing and disinfecting of filtration.

The preparation method of Tablets: get Herba Portulacae 1300g, Rhizoma Smilacis Glabrae 1300g, Herba Taraxaci 1200g, Rhizoma Osmundae 1100g, Fructus Sophorae 1200g, Fructus Forsythiae 1100g, Flos Lonicerae 1200g, Radix Rehmanniae 1200g, Rhizoma Polygoni Cuspidati 1200g, Radix Paeoniae Alba 1200g, Pericarpium Granati 1100g, Cortex Phellodendri 1200g, Radix Puerariae 1200g, Radix Angelicae Dahuricae 1200g, Semen Plantaginis 1200g, Radix Sanguisorbae 1200g, get crude drug and steep in water, soak more than 2 hours, add 8 times amount of crude drug gross weight respectively, the water gaging of 6 times amount extracts 2 times, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, and one-tenth extractum, for component becomes 1.The medicinal residues of crude drug said extracted crossed add ethanol, and add the ethanol warm macerating 2 times of 10 times amount of medicinal residues gross weight, 8 times amount respectively, the warm macerating time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merges 2 warm macerating liquid; Warm macerating liquid is evaporated to 1.05 extractum when density is 60 DEG C, and extractum is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes extractum, obtains component 2.By component 1 and component also 2-in-1, then put into concentrating under reduced pressure tank, reclaim ethanol, be concentrated into the paste of when density is 80 DEG C 1.20, use oven drying powdered, after ultraviolet sterilization, add starch and be pressed into tablet.

Pharmacological toxicity is tested

The animal acute toxicity test of pharmaceutical composition of the present invention

One, test material

(1) animal mouse NIH kind male and female half and half, body weight 20-22g, are provided by Shandong medical college Animal Lab..

(2) test medicine: the tablet prepared by the embodiment of the present invention, is diluted with distilled water into suspension.

Two, test method and result:

Mice maximum tolerance determination: get healthy mice 32, male and female half and half, divided three groups within 24 hours, and only, gross weight 1.8ml, is equivalent to crude drug in whole 4.0g to each 0.6ml/ of gavage intestinal, i.e. 100g crude drug/kg/d, is equivalent to 857 times of clinical 65 kilograms of people.After mice administration routinely feedstuff within 12 days, have no animal dead and do not go out, existing toxic reaction.Therefore prove, medicine of the present invention has no side effect, and clinical practice is safe and reliable.

The long-term toxicity test for animals of pharmaceutical composition of the present invention

One, test material and method

(1) test medicine: the capsule prepared by the embodiment of the present invention.

(2) laboratory animal, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and all death in 12 days is observed in remaining 1/2 drug withdrawal.

Two, test index

(1) general status comprises body weight, diet, emotion, movable energy.

(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counts.

(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.

(4) pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.

Three, Skin Irritation Test: above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine preparation long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.Result of the test shows: Chinese medicine preparation experiment safety of the present invention.

Four: cumulative toxicity is tested:

Traditional Chinese medicine preparation capsule agent of the present invention presses 7.69,19.18 and 43.21g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine preparation oral capsule of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Animal experiment:

In recent years, the research that objectifies of having blood in stool about traditional Chinese medical science syndrome of dampness-heat in large intestine is more, but there is not been reported for the relation of syndrome of dampness-heat in large intestine and cytokine. herein by setting up syndrome of dampness-heat in large intestine rat model, detection model rat blood serum IL-1, the Objective index that traditional Chinese medical science syndrome of dampness-heat in large intestine is had blood in stool is inquired in the change of IL-2 and IL-6 content.

1 materials and methods

1.1 experiment material

SD rat is provided by Shandong University's Experimental Animal Center, cleaning grade, male and female half and half, body weight 180-2209, high glucose and high fat feedstuff is produced by Qingdao Experimental Animal Center feed factory. and enteroinvasive E．Coli type strain is provided by epidemiology teaching and research room of No.1 Military Medical Univ., bacterium numbers 44813, concentration 1.0X 109/ml, nutrient agar slopes is adopted to cultivate 24h, normal saline eluting, Maxwell pipe is than turbid: high temperature storehouse is provided by Institute for Tropical Diseases of No.1 Military Medical Univ. high temperature research room, and totally enclosed type regulates temperature, humidity automatically; Inverted microscope: DM-IRB type, German LEICA company

Produce; Transmission electron microscope: JEOm type, Japan.The present invention: Herba Portulacae 12g, Rhizoma Smilacis Glabrae 13g, Herba Taraxaci 12g, Rhizoma Osmundae 10g, Fructus Sophorae 11g, Fructus Forsythiae 13g, Flos Lonicerae 12g, Radix Rehmanniae 11g, Rhizoma Polygoni Cuspidati 12g, Radix Paeoniae Alba 13g, Pericarpium Granati 12g, Cortex Phellodendri 12g, Radix Puerariae 12g, Radix Angelicae Dahuricae 13g, Semen Plantaginis 10g, Radix Sanguisorbae 13g.Gavage liquid is made according to 1g/ml.

1.2 experimental technique

1.2.1 modeling method

With reference to experimental technique, SD rat 32 is divided at random Normal group, syndrome of dampness-heat in large intestine model group, of the present invention group for the treatment of group, non-treatment group 4 groups, often organizes 8.Normal group: normal diet is fed, natural environment (temperature 22 DEG C, relative humidity 65%).Syndrome of dampness-heat in large intestine model group: first with high glucose and high fat forage feed 10d, then rat is placed in high temperature storehouse (temperature 35 DEG C, relative humidity 85%), every day continues 8h, with enteroinvasive E．Coli (concentration 1.0*10 after continuous 3d ⁹/ ml) gavage (2ml/ is only), after 24h, gavage once, feeds 1d under natural environment again.Treatment group of the present invention: as stated above after modeling, gives soup of the present invention (3ml/200g body weight) and is divided into 2 times/d, amounts to 7d.Non-treatment group: as stated above after modeling, will not any treatment.

1.2.2 detection method

Observation index: according to the clinical characters of syndrome of dampness-heat in large intestine, observes rat temperature (anus temperature), hair, the mental status, mobility, dietary amount, feces, has blood in stool, the situation such as tongue fur; Rat blood serum interleukin one I, one 2, ~ 6 quantitatively adopt radioimmunology (RIA) to detect by Chinese People's Liberation Army General Hospital's East Asia immunological technique institute.

1.3 statistical procedures adopt SPSSIO.0 statistical package, do t inspection, carry out significance analysis.

2 results

2.1 rats generally show

After animal enters high temperature storehouse, anus temperature has rising to a certain degree, is 37.6 DEG C one 38.2 DEG C, occurs that hair is fluffy, rolls up lazy dynamic, inappetence, but without other significant changes; After Escherichia Coli Injection 4h, anus temperature reaches honeybee and is worth about 39.7 DEG C, drop to about 38.5 DEG C gradually subsequently, overwhelming majority rat amount of drinking water and hypourocrinia, anus is red and swollen congested, beginning of having blood in stool, even anus dilating, model group rats major part occurs that stool is rare soft or half congealedly to rush down, and mucus bloody purulent stool appears in part, white and greasy fur or yellow greasy.After giving gavage 4h of the present invention, anus temperature starts to decline, and the fluctuation of anus temperature is at about 38 DEG C, and the symptoms such as the dull and anus of loose stool, inappetence, action is red and swollen are progressively alleviated, and major part recovering for the treatment of for 5-6 days completely.In non-treatment group rat 7d, most of symptom is without obvious alleviation, wherein 2 dead at the 6th and the 7th day respectively.

2.2 rat intestines organize macroscopy result

Syndrome of dampness-heat in large intestine model group and treatment matched group SD rat almost all occur that diffuse intestinal tube mucosa is congested, edema, there are a large amount of mucus and Fibrin exudation, there is little petechia partial rat intestinal tube local, these pathological changes are obvious with duodenum, ileum and sigmoid colon, rectum, and rats in normal control group intestinal tube is without any pathological change; Treatment group rat intestinal tube recovery situation of the present invention is good, and fundamental sum Normal group is identical.

2.3 rat blood serum IL-1, IL-2 and IL-6 assay is shown in form 1.

Table 1 rat blood serum IL-1, IL-2, IL-6 assay (x ± S, ng/mg)

Note: with natural matched group more 1. P < 0.01 and damp-heat in the large intestine model of pyretic syndrome group more 2. P < 0.05, with syndrome of dampness-heat in large intestine model group 3. P > 0.05

3, discuss

According to existing Immunology, T pouring is beaten up cell and can be secreted various active cytokine, and cytokine participates in lymphocytic growth, differentiation so, improves immunocompetence.

Traditional Chinese medical science six internal organs disease Research of Animal Model for Study is destroyed and is started from the nineties in last century, damp-heat in the large intestine causes to have blood in stool develops animal model for Main Basis with biological factor, chemistry because of rope, simulation symptom, objective mark, the compound of Chinese medicine removed, and our employing " hyperlipemia sugar+high temperature damp and hot+enteroinvasive E．Coli " tests model used for this.

It is burnt that the sick position of damp-heat syndrome relates to upper, middle and lower three, but inclined in lower two burnt, relate to many internal organs such as spleen is dived, liver and gall, kidney, wing an ancient wine vessel made of horn, intestinal.XUE Sheng-bai cloud: " middle QI excess then the disease being located in YANG position is bright, and middle gas Kang Ze is sick lunar, lunar internal injury, and wet drink stops gathering, and more extremely, inside and outside coupling, therefore sick damp and hot, this all first has internal injury to exopathogen, cotton-padded mattress arm exopathogen." at present a large amount of coral study carefully the immunity of margin real damp-heat syndrome essence and body and inflammatory process relevant, so its clinical research also many Pathophysiologys change to hand over and study.。

Pericarpium Granati yang invigorating antidiarrheal of the present invention, Semen Plantaginis and Cortex Phellodendri clearing away heat-fire, heat clearing and damp drying diuresis, Rhizoma Polygoni Cuspidati hemostasis removing dampness, four medicines share, and the effect of having blood in stool that treatment syndrome of dampness-heat in large intestine causes is better; Modern pharmacological research confirms Cortex Phellodendri, Semen Plantaginis all has antiinflammatory antivirus action, the antipyretic antiinflammatory of Flos Lonicerae, Fructus Forsythiae removing toxic substances heat clearing away, therefore comprehensive onset.

Clinical observation on the therapeutic effect

Observe the clinical efficacy that the present invention treats have loose bowels (syndrome of dampness-heat in large intestine is had blood in stool).Method: 180 routine patients are divided at random 2 groups of each 90 examples. treatment group gives the present invention treatment; Matched group GEGEN CENLIAN JIAONANG is treated.Result: total effective rate treatment group is 97.78%, matched group is 75.56%, 2 groups and compares, and difference is very significant (P < 0.01), and treatment group is better than matched group.

It is common clinical that Damp-heat syndrome is had blood in stool, and doctor trained in Western medicine is conventional with antibiotic therapy.Antibiotic applies the appearance and toxicity that inevitably cause drug resistance repeatedly, and this has become problem demanding prompt solution clinically.For reducing antibiotic use, the present invention has carried out the clinical research of having blood in stool from plan Empirical formula treatment Damp-heat syndrome, obtains significant curative effect.Result report is as follows.

1 clinical data

1.1 diagnostic criterias observe case Western medicine diagnose with reference to " infectious diarrhea is sick " relevant criterion: 1. onset anxious (what have slightly delays and increase the weight of gradually), all can fall ill throughout the year, high with sickness rate spring and summer.2. times of defecation increases, the loose stool of common yellow or redness of the skin or complexion or watery stool, has bad smell or is mixed with a small amount of mucus.3. can with heating, stomachache, nausea and vomiting, severe patient can cause dehydration and acidosis.4. stool routine examination inspection, visible a large amount of leukocyte or pus cell and erythrocyte.5. stool cultivation and cell separation serological Identification can be made a definite diagnosis.Standards of Chinese Medical Syndrome Differentiation is with reference to " Chinese medical disease Standardization of diagnosis and curative effect ", " new Chinese medicine guideline of clinical investigations " syndrome of dampness-heat in large intestine standard: 1. have loose bowels, every day more than 3 times, rush down urgently lower, rushes down and not well; 2. red tongue or light red, yellow fur or yellow greasy; 3. epigastric pain, scorching hot full vexed; 4. abdominal distention; 5. Nausea and vomiting; 6. generate heat; 7. excrement is yellow and smelly, burning sensation of the anus; Have blood in stool; 8. xerostomia, bitter taste; 9. yellow urine or short red.All meet above-mentioned 1., 2. bar add 3. ~ 9. any 2 persons in bar, can distinguish as syndrome of dampness-heat in large intestine is had blood in stool.

1. 1.2 inclusive criterias meet Western medicine diagnose and Standards of Chinese Medical Syndrome Differentiation person.2. 18 ~ 65 years old age, and be ready that clinical observers is carried out in cooperation.

1. 1.3 exclusion standards do not meet Western medicine diagnose and Standards of Chinese Medical Syndrome Differentiation person.2. the age is less than 18 years old or is greater than 65 years old person.3. serious disease person, tumor and the psychotics such as cardiovascular, liver, kidney and hemopoietic system is associated with.4. serious dehydration, acidosis, shock patients or heating is had more than 39 DEG C of persons; Bacillary dysentery, tuberculosis of intestine, inflammatory bowel patient; The state of an illness is critical, the unstable person of vital signs.5. antibiotic or other antiviral drugs was used before treatment.6. gestation or women breast-feeding their children.7. noncooperationist is treated.8. researcher is thought and should not carry out clinical trial person.

1.4 physical data are observed case and are in April, 2010 ~ 2011 Qingdao People's Hospital's tcm internal medicines in year April 1 and gastrointestinal training patient, and clinic case strictly controls variable factor.Totally 180 examples, are divided into 2 groups of each 90 examples at random by medical order.Treatment group man 35 example, female 55 example; 18 ~ 65 years old age, average 41 years old; The course of disease is the shortest 3 days, the longest January.Matched group man 46 example, female 44 example; 18 ~ 65 years old age, average 39 years old; The course of disease is the shortest 3 days, the longest January.2 groups of case ages, sex, courses of disease etc. are through statistical procedures, and difference there are no significant meaning (P > 0.05), has comparability.

2 Therapeutic Method

2.1 treatment group invention formulation, (composition: Herba Portulacae 12g, Rhizoma Smilacis Glabrae 13g, Herba Taraxaci 12g, Rhizoma Osmundae 10g, Fructus Sophorae 11g, Fructus Forsythiae 13g, Flos Lonicerae 12g, Radix Rehmanniae 11g, Rhizoma Polygoni Cuspidati 12g, Radix Paeoniae Alba 13g, Pericarpium Granati 12g, Cortex Phellodendri 12g, Radix Puerariae 12g, Radix Angelicae Dahuricae 13g, Semen Plantaginis 10g, Radix Sanguisorbae 13g.Produced by Pharmacy department of the court, make that dissolved granule is often little comprises crude drug amount 4.8g), each 1 bag, every day 3 times, take after mixing it with water, the course for the treatment of is 3 days.The Chinese patent medicine that viewing duration does not use any antibiotic, antiviral drugs and other drug effects similar.

2.2 matched group GEGEN CENLIAN JIAONANG (composition: Radix Puerariae, Radix Scutellariae, Rhizoma Coptidis, Radix Glycyrrhizae.Every 0.4g, is produced by Chongqing three ring pharmaceutcal corporation, Ltd), each 4, every day 3 times, oral, the course for the treatment of is 3 days.The Chinese patent medicine that viewing duration does not use any antibiotic, antiviral drugs and other drug effects similar.

3 criterions of therapeutical effect and therapeutic outcome

3.1 criterions of therapeutical effect are with reference to " Chinese medical disease Standardization of diagnosis and curative effect " I and " new Chinese medicine guideline of clinical investigations " ... relevant criterion is formulated and is cured: disappearance of having blood in stool, and relevant abnormal physical and chemical index recovers normal to having loose bowels; Therapeutic index >=95%.Effective: primary symptom disappears substantially, secondary disease is obviously improved, and stool is approximate to be shaped, or loose stool every day only 1 time, to relevant abnormal physical and chemical index of having loose bowels close to normal; Therapeutic index 75%-95%.Effective: times of defecation and matter, disease and sign are improved, and relevant abnormal physical and chemical index takes a turn for the better to having loose bowels; Therapeutic index 30%-74%.Invalid: symptom, sign, without improvement, are had blood in stool still, to relevant abnormal physical and chemical index of having loose bowels without improvement; Therapeutic index < 30%.

Therapeutic index: [(treat front integration one and treat rear integration) ÷ treats front integration] X100%.

3.22 groups of Clinical efficacy comparisons are in table 1.Total effective rate treatment group is 97.78%, and matched group is 75.56%, 2 groups and compares, and difference is very significant (P < 0.01), and treatment group curative effect is better than matched group.

Table 12 group Clinical efficacy comparison example (%)

Compare with matched group, 1. P < 0.01

4 discuss

Claims

1. the Chinese medicine preparation for the treatment of Damp-heat syndrome and having blood in stool, it is characterized in that, the parts by weight of the crude drug of described Chinese medicine preparation comprise: Herba Portulacae 10 ~ 20 parts, Rhizoma Smilacis Glabrae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Rhizoma Osmundae 10 ~ 20 parts, the Fructus Sophorae 10 ~ 20 parts, Fructus Forsythiae 10 ~ 20 parts, Flos Lonicerae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Pericarpium Granati 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Radix Sanguisorbae 10 ~ 20 parts.

2. treat the Chinese medicine preparation that Damp-heat syndrome is had blood in stool according to claim 1, it is characterized in that, the parts by weight of the crude drug of described Chinese medicine preparation comprise: Herba Portulacae 10 ~ 15 parts, Rhizoma Smilacis Glabrae 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts, Rhizoma Osmundae 10 ~ 15 parts, the Fructus Sophorae 10 ~ 15 parts, Fructus Forsythiae 10 ~ 15 parts, Flos Lonicerae 10 ~ 15 parts, 10 ~ 15 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Pericarpium Granati 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Radix Sanguisorbae 10 ~ 20 parts.

3. treat the Chinese medicine preparation that Damp-heat syndrome is had blood in stool according to claim 1, it is characterized in that, the parts by weight of the crude drug of described Chinese medicine preparation comprise: Herba Portulacae 10 ~ 20 parts, Rhizoma Smilacis Glabrae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Rhizoma Osmundae 10 ~ 20 parts, the Fructus Sophorae 10 ~ 20 parts, Fructus Forsythiae 10 ~ 20 parts, Flos Lonicerae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Pericarpium Granati 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Radix Sanguisorbae 10 ~ 20 parts.

4. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine preparation that Damp-heat syndrome is had blood in stool, it is characterized in that, the dosage form of described preparation is that the preparation process of tablet comprises:

5. treat the preparation method of the Chinese medicine preparation that Damp-heat syndrome is had blood in stool according to claim 4, it is characterized in that, in described step a, getting crude drug steeps in water, soak more than 2 hours, add the water extraction 2 times of 8 times amount of crude drug gross weight, 6 times amount respectively, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, and one-tenth extractum, for component becomes 1.

6. treat the preparation method of the Chinese medicine preparation that Damp-heat syndrome is had blood in stool according to claim 4, it is characterized in that, in described step b, the medicinal residues of crude drug said extracted crossed add ethanol, add the ethanol warm macerating 2 times of 10 times amount of medicinal residues gross weight, 8 times amount respectively, the warm macerating time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merges 2 warm macerating liquid; Warm macerating liquid is evaporated to 1.25 extractum when density is 60 DEG C, and extractum is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes extractum, obtains component 2.

7. treat the preparation method of the Chinese medicine preparation that Damp-heat syndrome is had blood in stool according to claim 4, it is characterized in that, in described step c, by component 1 and component also 2-in-1, then put into concentrating under reduced pressure tank, reclaim ethanol, be concentrated into the paste of when density is 80 DEG C 1.20, use oven drying powdered, after ultraviolet sterilization, add starch and be pressed into tablet.

8. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine preparation that Damp-heat syndrome is had blood in stool, it is characterized in that, the dosage form of described preparation is that the preparation process of enema comprises:

9. treat the preparation method of the enema that Damp-heat syndrome is had blood in stool according to claim 8, it is characterized in that, step filtrate be condensed in above-mentioned steps is: get twice decocting liquid mixing, filter, the filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, density is the extractum of 1.20, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, extractum is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, fill after ultraviolet sterilization.

10. according to any one of claim 1 ~ 9, treat the Chinese medicine preparation that Damp-heat syndrome is had blood in stool, it is characterized in that, the dosage form of described Chinese medicine preparation is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, dissolved granule, pill, powder, sublimed preparation, enema or injection.