CN106563095A - Compound preparation for dental ulcer, and preparation method of compound preparation - Google Patents

Compound preparation for dental ulcer, and preparation method of compound preparation Download PDF

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CN106563095A
CN106563095A CN201611001360.9A CN201611001360A CN106563095A CN 106563095 A CN106563095 A CN 106563095A CN 201611001360 A CN201611001360 A CN 201611001360A CN 106563095 A CN106563095 A CN 106563095A
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rhizoma atractylodis
atractylodis macrocephalae
root bark
tree peony
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王汉明
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract

The invention provides a formula of a compound preparation for dental ulcer, and a preparation method of the compound preparation. The compound preparation for the dental ulcer is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-17 parts of rhizoma smilacis glabrae, 10-17 parts of dandelion, 10-17 parts of herba hedyotis diffusae, 8-15 parts of radix scrophulariae, 8-15 parts of radix rehmanniae, 8-15 parts of radix paeoniae rubra, 8-15 parts of cortex moutan, 8-15 parts of radix arnebiae seu lithospermi, 10-17 parts of poria cocos, 8-15 parts of roasted rhizoma atractylodis macrocephalae, 8-15 parts of bletilla striata and 7-14 parts of unprocessed radix glycyrrhizae. The formula is used for the dental ulcer, is fine in compatibility of medicines, rigorous and free from toxic and side effects, has the functions of clearing heat and toxins, nourishing yin, activating blood, tonifying spleen and promoting tissue regeneration, and has a good effect for treating the dental ulcer.

Description

A kind of oral ulcer compound preparation and preparation method thereof
Technical field
The present invention relates to dental ulcer treatment field, the formula of specifically a kind of oral ulcer compound preparation and preparation side Method.
Background technology
Canker sore is a kind of common disease of cari oris mucosa, is the shallow property of table occurred on oral mucosa also known as aphtha Ulcer, big I is from the grain of rice to soya bean size, circular or oval, and ulcer surface is congested in recessed, surrounding.Canker sore is oral cavity A kind of disease of incidence of disease highest in mucous membrane disease, common cold, indigestion, stress, it is gloomy not happy situations such as equal energy Accidentally cause the generation of the disease, be apt to occur in lip, cheek, lingual margin etc., age of onset is typically between 10～30 years old, and women is more, one The four seasons in year can occur.The features such as ulcer has periodicity, recurrent and self limiting, is apt to occur in lip, cheek, lingual margin etc..During outbreak Clearly, the work and life to patient causes very big impact to pain.Recurrent exerbation, cusalgia unbearably, while can cause Multiple complications.The dialectical recurrent oral ulceration of traditional Chinese medical science institute is that the heresy of the diseases caused by external factors six external factors which cause diseases causes liver because inernal injuries caused by seven emotions, ferritic are weak The strongly fragrant stagnation of the circulation of vital energy, hot and suffocatingization fire, internal heat is flourishing, and rising up of the stomach-fire, breakdown of the normal physiological coordination between the heart and the kidney, flaring up of deficient fire is fumigated and fallen ill in mouth.
The content of the invention
The present invention is attacked and rushed in upper pathogenesis, there is provided a kind of canker sore compound according to the accumulation of heart and spleen of canker sore The formula and preparation method of preparation, said preparation preferably clearing heat and detoxicating, nourishing yin and activating blood, invigorating the spleen myogenic, reaches the effect for the treatment of canker sore Really.
A kind of oral ulcer compound preparation, is formulated by the Chinese medicine material of following weight parts：Smilax 10-17 parts, Pu Public English 10-17 parts, oldenlandia diffusa 10-17 parts, radix scrophulariae 8-15 parts, dried rhizome of rehmannia 8-15 parts, radix paeoniae rubrathe 8-15 parts, root bark of tree peony 8-15 parts, purple Careless 8-15 parts, Poria cocos 10-17 parts, rhizoma atractylodis macrocephalae 8-15 parts, bletilla striata 8-15 parts, licorice 7-14 part.
Further, 15 parts of smilax, 15 parts of dandelion, 15 parts of oldenlandia diffusa, 12 parts of radix scrophulariae, 12 parts of the dried rhizome of rehmannia, the radix paeoniae rubrathe 12 parts, 12 parts of the root bark of tree peony, 12 parts of Asian puccoon, 15 parts of Poria cocos, 12 parts of rhizoma atractylodis macrocephalae, 12 parts of the bletilla striata, 10 parts of licorice.
A kind of preparation method for treating canker sore compound granular, comprises the following steps：
(1) raw material is weighed by formula：Smilax, dandelion, oldenlandia diffusa, radix scrophulariae, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the root bark of tree peony, Asian puccoon, Poria cocos, rhizoma atractylodis macrocephalae, the bletilla striata, licorice；
(2) 12 taste more than, the bletilla striata is ground into fine powder, standby；The root bark of tree peony, rhizoma atractylodis macrocephalae extraction by steam distillation volatilize Oil, the volatile oil after distillation is collected in addition；The root bark of tree peony, the dregs of a decoction of rhizoma atractylodis macrocephalae and other nine tastes, add the water of its 10 times of weight Decoction is secondary, 1.5 hours every time, filters, then adds ethanol to make ethanol mass concentration up to 70% in filtrate, stands, and filters, Decompression recycling ethanol at 80 DEG C, is concentrated into the clear cream that relative density is 1.15～1.20, adds bletilla striata fine powder, mixes, 80 DEG C Drying under reduced pressure, crush, sieve, add the 20% of its quality sucrose, pelletize, be dried, the penetratings root bark of tree peony and rhizoma atractylodis macrocephalae extraction Volatile oil, mixes, and obtains final product.
A kind of preparation method of oral ulcer compound preparation capsule, comprises the following steps：
(1) raw material is weighed by formula：Smilax, dandelion, oldenlandia diffusa, radix scrophulariae, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the root bark of tree peony, Asian puccoon, Poria cocos, rhizoma atractylodis macrocephalae, the bletilla striata, licorice；
(2) 12 taste more than, the bletilla striata is ground into fine powder, standby；The root bark of tree peony, rhizoma atractylodis macrocephalae extraction by steam distillation volatilize Oil, the volatile oil after distillation is collected in addition；The root bark of tree peony, the dregs of a decoction of rhizoma atractylodis macrocephalae and other nine tastes, add the water of its 10 times of weight Decoction is secondary, 1.5 hours every time, filters, and filtrate adds ethanol to make mass concentration containing ethanol up to 70%, stands, and filters, at 80 DEG C Lower decompression recycling ethanol, is concentrated into the clear cream that relative density is 1.15～1.20, adds bletilla striata fine powder, mixes, and 80 DEG C of decompressions are dry It is dry, crush, sieve, the 50% of its quality starch is added, pelletize, it is dried, the volatile oil that the penetrating root bark of tree peony and rhizoma atractylodis macrocephalae are extracted, The 0.5% of its quality magnesium stearate is added, is mixed, load capsule, obtained final product.
A kind of preparation method of canker sore compound decoction, comprises the following steps：By prescription weigh smilax, dandelion, Oldenlandia diffusa, radix scrophulariae, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the root bark of tree peony, Asian puccoon, Poria cocos, rhizoma atractylodis macrocephalae, the bletilla striata, licorice；With above-mentioned Chinese medicine material The water of 8-12 times of weight soaks 1 hour, and heating is boiled, and from boiling timing is started, and 1 hour is boiled every time, decocts 2 times, merges, point Use is warmly taken twice.
Fang Xie：
Smilax is mild-natured cooler, energy eliminating dampness and heat, removing toxic substances more sore, is usually used in the damp and hot sore for causing.Smilax is to golden yellow Color staphylococcus, hemolytic streptococcus have inhibitory action, and have obvious analgesic activity.
Dandelion is cold in nature, sweet, slight bitter, clearing heat, releasing toxin, removing swelling.Dandelion is to staphylococcus aureus, hemolytic streptococcus And micrococcus catarrhalis has stronger inhibitory action, moreover it is possible to the immunologic function of excitating organism.
Oldenlandia diffusa can significantly increase the immunocompetence of body, and reticuloendothelial system hyperplasia can be stimulated in vivo, promote Antibody is formed, and is made the phagocytic activity of desmacyte, leucocyte and is strengthened, so as to reach antibacterial, the purpose of anti-inflammatory.
Radix scrophulariae has antiinflammatory action, energy clearing heat and cooling blood, nourishing Yin and promoting production of body fluid；
The dried rhizome of rehmannia can strengthen the phagocytic function of reticuloendothelial cell, strengthen humoral immunity and cellular immune function；
The radix paeoniae rubrathe has stronger inhibitory action to multiple pathogenic microorganisms, and contained Paeoniflorin has antipyretic-antalgic, antiinflammatory action；It is red Moutan bark phenol contained by skin and its glucosides constituents in addition have anti-inflammatory, analgesia, antiulcer action；
Asian puccoon has obvious antipyretic, anti-inflammatory, anastalsis；
Poria cocos can improve body immunity, and strengthening the spleen and stomach, Li Shui dehumidifying makes the strong fortune of taste, and healthy tendency is sufficient, and heresy can not be done, It is wet to have no way of poly-.
The bighead atractylodes rhizome also has antiulcer, resisting stress, anti-oxidant, antibacterial etc. to act on；
It is bletilla striata bitter, sweet, puckery, it is slightly cold, the effect of with astringing to arrest bleeding, detumescence and promoting granulation；And have that " myogenic controls sore, surgery It is most kind " title；
Radix Glycyrrhizae can be clearing heat and detoxicating, strengthens all medicines and clears away heart-fire Jing heat evils, the work(of healing up sore and subduing swelling, but can coordinating the drug actions of a prescription and with to make Medicine, and modern study Radix Glycyrrhizae has antiulcer, antibacterial, antiviral, antiinflammatory action.
The present invention formula be directed to canker sore, meticulous compatibility, prescription is rigorous, and has no toxic side effect, with it is clearing heat and detoxicating, The function of nourishing yin and activating blood, invigorating the spleen myogenic is good to treating canker sore effect.
Description of the drawings
Fig. 1 is Normal oral mucosa HE colored graphs (× 200)；
Fig. 2 is canker sore mucous membrane HE colored graphs (× 200).
Specific embodiment
With reference to specific embodiment, the present invention is described further.
Embodiment 1
Formula：15 parts of smilax, 15 parts of dandelion, 15 parts of oldenlandia diffusa, 12 parts of radix scrophulariae, 12 parts of the dried rhizome of rehmannia, 12 parts of the radix paeoniae rubrathe, 12 parts of the root bark of tree peony, 12 parts of Asian puccoon, 15 parts of Poria cocos, 12 parts of rhizoma atractylodis macrocephalae, 12 parts of the bletilla striata, 10 parts of licorice.
Preparation method：(1) raw material is weighed by formula：Smilax, dandelion, oldenlandia diffusa, radix scrophulariae, the dried rhizome of rehmannia, the radix paeoniae rubrathe, pellet Skin, Asian puccoon, Poria cocos, rhizoma atractylodis macrocephalae, the bletilla striata, licorice；
(2) 12 taste more than, the bletilla striata is ground into fine powder, standby；The root bark of tree peony, rhizoma atractylodis macrocephalae extraction by steam distillation volatilize Oil, the volatile oil after distillation is collected in addition；The root bark of tree peony, the dregs of a decoction of rhizoma atractylodis macrocephalae and other nine tastes, add the water of its 10 times of weight Decoction is secondary, 1.5 hours every time, filters, then adds ethanol to make ethanol mass concentration up to 70% in filtrate, stands, and filters, Decompression recycling ethanol at 80 DEG C, is concentrated into the clear cream that relative density is 1.15～1.20, adds bletilla striata fine powder, mixes, 80 DEG C Drying under reduced pressure, crush, sieve, add the 20% of its quality sucrose, pelletize, be dried, the penetratings root bark of tree peony and rhizoma atractylodis macrocephalae extraction Volatile oil, mixes, and obtains final product.
Embodiment 2
Formula：10 parts of smilax, 10 parts of dandelion, 10 parts of oldenlandia diffusa, 8 parts of radix scrophulariae, 8 parts of the dried rhizome of rehmannia, 8 parts of the radix paeoniae rubrathe, pellet 8 parts of skin, 8 parts of Asian puccoon, 10 parts of Poria cocos, 8 parts of rhizoma atractylodis macrocephalae, 8 parts of the bletilla striata, 7 parts of licorice.
Preparation method：By prescription weigh smilax, dandelion, oldenlandia diffusa, radix scrophulariae, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the root bark of tree peony, Asian puccoon, Poria cocos, rhizoma atractylodis macrocephalae, the bletilla striata, licorice；Soaked 1 hour with the 8-12 times of water measured, heating is boiled, start timing from boiling, every time 1 hour is boiled, is decocted 2 times, merged, use is warmly taken at twice.
Embodiment 3
Formula：17 parts of smilax, 17 parts of dandelion, 17 parts of oldenlandia diffusa, 15 parts of radix scrophulariae, 15 parts of the dried rhizome of rehmannia, 15 parts of the radix paeoniae rubrathe, 15 parts of the root bark of tree peony, 15 parts of Asian puccoon, 17 parts of Poria cocos, 15 parts of rhizoma atractylodis macrocephalae, 15 parts of the bletilla striata, 14 parts of licorice.
Preparation method：(1) raw material is weighed by formula：Smilax, dandelion, oldenlandia diffusa, radix scrophulariae, the dried rhizome of rehmannia, the radix paeoniae rubrathe, pellet Skin, Asian puccoon, Poria cocos, rhizoma atractylodis macrocephalae, the bletilla striata, licorice；
(2) 12 taste more than, the bletilla striata is ground into fine powder, standby；The root bark of tree peony, rhizoma atractylodis macrocephalae extraction by steam distillation volatilize Oil, the volatile oil after distillation is collected in addition；The root bark of tree peony, the dregs of a decoction of rhizoma atractylodis macrocephalae and other nine tastes, add the water of its 10 times of weight Decoction is secondary, 1.5 hours every time, filters, and filtrate adds ethanol to make mass concentration containing ethanol up to 70%, stands, and filters, at 80 DEG C Lower decompression recycling ethanol, is concentrated into the clear cream that relative density is 1.15～1.20, adds bletilla striata fine powder, mixes, and 80 DEG C of decompressions are dry It is dry, crush, sieve, the 50% of its quality starch is added, pelletize, it is dried, the volatile oil that the penetrating root bark of tree peony and rhizoma atractylodis macrocephalae are extracted, The 0.5% of its quality magnesium stearate is added, is mixed, load capsule, obtained final product.
It is below the explanation of zoopery and the clinical observation of this medicine using effect.
Zoopery
(1) experiment purpose:By observation experiment rat canker sore healing state and detection serum mesocuticle cell growth The factor (EGF) and mucous membrane of mouth obtain EGF-R ELISA (EGFR) level to evaluate inventive formulation to experimental rat The therapeutic effect of canker sore, and its mechanism of action is inquired into, so as to provide theoretical foundation for clinical practice.
(2) experiment material
1. animal used as test：SPF levels Wistar rat 80, body weight about 180-200g, male is selected (to be purchased from Hubei Province's disease control Center animal used as test section.Lot number 00013671) pellet raises, and pure water drinks, 18 ± 2 DEG C of room temperature, and relative humidity is average For 48 ± 2%.
2. reagent and instrument：
Agents useful for same EGF and EGFR monoclonal antibody are rabbit-anti murine monoclonal concentrated type antibody, SABC kits, concentration Type SABC S-P kits and DAB colour reagent boxes.Paraffin slicing machine needed for test, insulating box, light microscope, The equipment such as heater, centrifuge, homogenizer, -80 DEG C of refrigerators, -20 DEG C of refrigerators, electronic balance and common instrument and reagent (by Hubei institute of traditional Chinese medicine laboratory provides).
3. experimental drug：NaOH crystal, 10g/L yellow Jackets
4. medicine：No. 1 side of aphtha：It is smilax 15g, dandelion 15g, oldenlandia diffusa 15g, radix scrophulariae 12g, dried rhizome of rehmannia 12g, red Chinese herbaceous peony 12g, root bark of tree peony 12g, Asian puccoon 12g, Poria cocos 15g, rhizoma atractylodis macrocephalae 12g, bletilla striata 12g, licorice 10g.And it is fried into concentration 150% (being provided by the fried room of Chinese medicine pharmacy of Hubei Province).
(3) experimental technique
1. the foundation of experimental rat Oral ulcer model and sample are taken：Rat is in 10g/L yellow Jackets (0.025g/kg) under anaesthetizing, form a diameter of 3mm's afterwards by burning the 5-8 seconds at bicker mucous membrane in side lower lip with NaOH crystal Ulcer, rear normal saline flushing.
2. the rat after modeling success and normal rat are respectively randomly selected into 20 acute execution, take and glued at canker sore Film, sample is put 10% formalin and is fixed, HE dyeing row morphological observations.EGFR levels are detected using ImmunohistochemistryMethods Methods, Rat eye socket takes blood, using EGF levels in enzyme linked immunosorbent assay (ELISA) detection rat peripheral blood.
3. by modeling after remaining rat be randomly divided into two groups, No. 1 side's treatment of medication therapy groups application aphtha, dosage 15g Crude drug/Kg, gavage of weighing daily 1 time；Control group is weighed and gives physiological saline gavage；Normal group refuses drug-treated.Clinic is seen Examine from cause wound next day, daily observation rat oral cavity healing state traces ulcer area.
4. gavage takes mucous membrane at canker sore after 5 days, and sample is put 10% formalin and fixed, and HE dyeing row morphology is seen Examine.EGFR levels are detected using ImmunohistochemistryMethods Methods.Blood is taken using rat eye socket after gavage, enzyme linked immunosorbent assay is utilized respectively (ELISA) EGF levels in two groups of rat peripheral blood are detected.
(4) experimental result
1. the cardinal symptom of each group rat changes with sign
Clinical observation result measures the diameter in oral cavity to visually observe with slide measure, calculates two groups of ulcer sizes, observation As a result：Increased day by day using rat body weight before chemicals calcination method modeling, activity is normal, appetite is good, stool is normal, dorsal body setae Gloss, reaction is flexible, and urine is yellowish；Modeling deutostoma lip is moist, slobber, and loses weight, and food ration amount of drinking water is reduced, fur Coarse, scrotum relaxes sagging, and activity is reduced, and the yellow amount of urine is few, defecates shapeless.It is as shown in table 1 rat aphtha 1 after modeling The changes of weight of experimental group and saline control group, is as shown in table 2 No. 1 experimental group of rat aphtha and physiological saline after modeling The experimental result of the ulcer area size of control group, is relatively dried after No. 1 side's treatment of oral sore around lip, and drinking-water slightly increases with body weight Plus, hair color is bright earlier above, and activity is normal, and stool and urine is normal, and canker sore area reduces, and weight recovery is very fast, control group symptom Recover slow compared with treatment group with sign.
The rat experiment group of table 1, control group changes of weight
The rat test group of table 2, control group ulcer area size
2. om observation tissue change
Fig. 1 is Normal oral mucosa HE colored graphs (× 200), and normal group mucosal epithelium is complete under light microscopic, and lower section is loose Connective tissue, Fig. 2 is canker sore mucous membrane HE colored graphs (× 200), and the dissolving of modeling epithelium posterius ulceration comes off, and surface covers necrosis Tissue, there is a large amount of cell infiltrations, mostly lymphocyte and neutrophil leucocyte under mucous membrane, vascular endothelial cell necrosis, epithelium is thin There is obvious cell infiltration, forms a large amount of sloughs in karyon fragmentation, pyknosis, deep dye, upper intracutaneous, have around slough compared with Many fibroblast, new capillary vessel etc..
3. rat experiment group, the expression change of control group Serum EGF concentration
It is as shown in table 3 that No. 1 experimental group of aphtha and saline control group are detected using enzyme linked immunosorbent assay (ELISA) The result of EGF levels in rat blood serum.EGF is significantly reduced compared with normal rat in rat blood serum after modeling, using pharmaceutical formulation and After saline therapy, EGF levels have been raised in two groups of rat blood serums of No. 1 experimental group of aphtha and saline control group, Experimental group EGF level is raised soon compared with control group, and there were significant differences between two groups.
The rat experiment group of table 3, control group Serum EGF concentration concentration
4. rat experiment group, the expression change of control group Serum EGF concentration R
Detect the table of EGFR using ImmunohistochemistryMethods Methods for No. 1 experimental group of aphtha and saline control group as shown in table 4 Up to the result of OD values.EGFR is significantly reduced compared with normal rat in rat blood serum after modeling, is controlled using pharmaceutical formulation and physiological saline After treatment, EGFR levels have been raised in two groups of rat blood serums of No. 1 experimental group of aphtha and saline control group, experimental group EGFR Level is raised soon compared with control group, and there were significant differences between two groups.
The rat experiment group of table 4, the EGFR expression OD values of control group
(5) conclusion
1. the medicament that this formula makes can significantly improve canker sore symptom, promote ulcer healing.
2. EGF, EGFR level when the medicament that this formula makes can adjust canker sore, strengthens mucous membrane of mouth reparation energy Power.
Clinical research
1st, medical record situation
Treatment patient 60, severe one 21, compared with the lighter 39.
2nd, diagnostic criteria presses Western medicine diagnostic criteria.
3rd, efficacy assessment standard：
It is effective：Without mucous hyperemia or blush shape around canker sore, ulcer wound surface disappear, with pain and with head Bitterly, the symptom such as heating, regional glandular enlargement disappears.
Effectively：Canker sore size, number are reduced, and around have blush, and sense pain substantially mitigates.
It is invalid：Canker sore surrounding mucosa is congested or blush shape, and ulcer wound surface is not changed in, with pain and with head Bitterly, the symptom such as heating, regional glandular enlargement.
4th, dosage and time
Time of Administration：1 week -3 all (medicine time is determined according to light and heavy degree).
Treatment group 60, effective 38 (63%), effective 21 (35%), invalid 1 (2%).Total effective rate is 96%.
Typical case：
Certain man：49 years old, Blood of Patients with Recurrent Oral, recurrent exerbation had the several months long, hurt like hell, and diet is difficult, entirely Body discomfort etc., after 1 week, symptom is clearly better to have taken granular preparation obtained in example (1), fully recovers after taking 2 weeks.
Certain female：32 years old, canker sore recurrent exerbation more than 1 year, Chinese and Western medicine internal and external treatment failed all the time control outbreak, each Once, sometimes youngster is without the obvious intermittent phase for the outbreak of the moon or two months.The oral cavity the tip of the tongue, tooth cheek, tooth eye and lower lip inner edge have mung bean big Small circular ulcer, in faint yellow, surface indentation, edge dimpling.Take obtained in embodiment (2) that decoction is after 2 weeks, symptom is obvious Take a turn for the better, take a turn for the better after taking January, almost do not recur.
Certain man：55 years old, Blood of Patients with Recurrent Oral, recurrent exerbation, hurt like hell, diet difficulty etc..Enforcement is taken Capsule preparations obtained in example (3).Remission after one week, cures after 3 weeks.
The detailed description of specific embodiments of the present invention is the foregoing is only, the present invention is not limited with this, it is all at this Any modification, equivalent and improvement for being made in the mentality of designing of invention etc., should be included in protection scope of the present invention it It is interior.

Claims (5)

1. a kind of oral ulcer compound preparation, it is characterised in that be formulated by the Chinese medicine material of following weight parts：Smilax 10- 17 parts, dandelion 10-17 parts, oldenlandia diffusa 10-17 parts, radix scrophulariae 8-15 parts, dried rhizome of rehmannia 8-15 parts, radix paeoniae rubrathe 8-15 parts, root bark of tree peony 8- 15 parts, Asian puccoon 8-15 parts, Poria cocos 10-17 parts, rhizoma atractylodis macrocephalae 8-15 parts, bletilla striata 8-15 parts, licorice 7-14 part.
2. oral ulcer compound preparation according to claim 1, it is characterised in that matched somebody with somebody by the Chinese medicine material of following weight parts System is formed：15 parts of smilax, 15 parts of dandelion, 15 parts of oldenlandia diffusa, 12 parts of radix scrophulariae, 12 parts of the dried rhizome of rehmannia, 12 parts of the radix paeoniae rubrathe, the root bark of tree peony 12 Part, 12 parts of Asian puccoon, 15 parts of Poria cocos, 12 parts of rhizoma atractylodis macrocephalae, 12 parts of the bletilla striata, 10 parts of licorice.
3. a kind of preparation method for treating canker sore compound granular, it is characterised in that comprise the following steps：
(1) raw material is weighed by formula：Smilax, dandelion, oldenlandia diffusa, radix scrophulariae, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the root bark of tree peony, Asian puccoon, Poria cocos, Rhizoma atractylodis macrocephalae, the bletilla striata, licorice；
(2) 12 taste more than, the bletilla striata is ground into fine powder, standby；The root bark of tree peony, rhizoma atractylodis macrocephalae extraction by steam distillation volatile oil, steams Volatile oil after evaporating is collected in addition；The root bark of tree peony, the dregs of a decoction of rhizoma atractylodis macrocephalae and other nine tastes, the decocting for adding its 10 times of weight boils two It is secondary, 1.5 hours every time, filter, then add ethanol to make ethanol mass concentration up to 70% in filtrate, and stand, filter, at 80 DEG C Decompression recycling ethanol, is concentrated into the clear cream that relative density is 1.15～1.20, adds bletilla striata fine powder, mixes, and 80 DEG C of decompressions are dry It is dry, crush, sieve, the 20% of its quality sucrose is added, pelletize, it is dried, the volatile oil that the penetrating root bark of tree peony and rhizoma atractylodis macrocephalae are extracted, Mix, obtain final product.
4. a kind of preparation method of oral ulcer compound preparation capsule, it is characterised in that comprise the following steps：
(1) raw material is weighed by formula：Smilax, dandelion, oldenlandia diffusa, radix scrophulariae, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the root bark of tree peony, Asian puccoon, Poria cocos, Rhizoma atractylodis macrocephalae, the bletilla striata, licorice；
(2) 12 taste more than, the bletilla striata is ground into fine powder, standby；The root bark of tree peony, rhizoma atractylodis macrocephalae extraction by steam distillation volatile oil, steams Volatile oil after evaporating is collected in addition；The root bark of tree peony, the dregs of a decoction of rhizoma atractylodis macrocephalae and other nine tastes, the decocting for adding its 10 times of weight boils two It is secondary, 1.5 hours every time, to filter, filtrate adds ethanol to make mass concentration containing ethanol up to 70%, stands, and filters, and reduces pressure at 80 DEG C Ethanol is reclaimed, the clear cream that relative density is 1.15～1.20 is concentrated into, bletilla striata fine powder is added, is mixed, 80 DEG C of drying under reduced pressure, powder It is broken, sieve, the 50% of its quality starch is added, pelletize, it is dried, the volatile oil that the penetrating root bark of tree peony and rhizoma atractylodis macrocephalae are extracted is added The magnesium stearate of the 0.5% of its quality, mixes, and loads capsule, obtains final product.
5. a kind of preparation method of canker sore compound decoction, it is characterised in that comprise the following steps：By prescription weigh smilax, Dandelion, oldenlandia diffusa, radix scrophulariae, the dried rhizome of rehmannia, the radix paeoniae rubrathe, the root bark of tree peony, Asian puccoon, Poria cocos, rhizoma atractylodis macrocephalae, the bletilla striata, licorice；Use above-mentioned Chinese medicine The water of 8-12 times of weight of raw material soaks 1 hour, and heating is boiled, and from boiling timing is started, and 1 hour is boiled every time, decocts 2 times, Merge, use is warmly taken at twice.
CN201611001360.9A 2016-11-10 2016-11-10 Compound preparation for dental ulcer, and preparation method of compound preparation Pending CN106563095A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113456602A (en) * 2021-07-01 2021-10-01 李霞 Plant buccal mucosa fibrosis buccal tablet and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102119979A (en) * 2011-03-01 2011-07-13 徐州工业职业技术学院 Oral ulcer compound preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102119979A (en) * 2011-03-01 2011-07-13 徐州工业职业技术学院 Oral ulcer compound preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113456602A (en) * 2021-07-01 2021-10-01 李霞 Plant buccal mucosa fibrosis buccal tablet and preparation method thereof

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Application publication date: 20170419