CN106491937A - A kind of Chinese medicine for treating syndrome of dampness-heat in large intestine - Google Patents

A kind of Chinese medicine for treating syndrome of dampness-heat in large intestine Download PDF

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Publication number
CN106491937A
CN106491937A CN201611211756.6A CN201611211756A CN106491937A CN 106491937 A CN106491937 A CN 106491937A CN 201611211756 A CN201611211756 A CN 201611211756A CN 106491937 A CN106491937 A CN 106491937A
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radix
heat
intestine
dampness
chinese medicine
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CN201611211756.6A
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Chinese (zh)
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闫大伟
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闫大伟
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • A61K36/195Strobilanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/30Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/44Ebenaceae (Ebony family), e.g. persimmon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965Asparagus, e.g. garden asparagus or asparagus fern

Abstract

The invention discloses a kind of Chinese medicine for treating syndrome of dampness-heat in large intestine, is made up of Chinese herbal medicine semen momordicae, phoenix-tail fern, yncaria stem with hooks, bamboo honeybee, lucid asparagus, water chestnut, propolis, persimmon sugar, flying apsaras, indigo naturalis, bicolor, sweet wormwood, the seed of feather cockscomb, radix ampelopsis, Radix Rhapontici seu Radix Echinopsis, sheep hoof, Asian puccoon, Radix picrorrhizae.The present invention treats both principal and secondary aspect of disease with pure natural Chinese herbal medicine as raw material, determined curative effect, has no toxic side effect, and is difficult to recur.

Description

A kind of Chinese medicine for treating syndrome of dampness-heat in large intestine
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of Chinese medicine for treating syndrome of dampness-heat in large intestine.
Background technology
Syndrome of dampness-heat in large intestine refers to the syndrome showed by damp and hot invasion and attack large intestine.Many because eating and drinking without temperance unclean, damage stomach, damp and hot Heresy take advantage of a weak point in opponent's defence enemy intrusion or invasion caused by.Damp and hot invasion and attack large intestine, stops up air resister, therefore suffers from abdominal pain, tenesmus;Damp and hot smoked bright enteron aisle, train of thought are damaged, Blood corruption is into purulence, therefore the red white purulence blood of diarrhea;Damp invasion of lower energizer, water paddy conduction mistake department, is unable to distinguish between the clear and the muddy, therefore emergent diarrhea and tenesmus, color Huang and smelly;Wet Resistance large intestine, the hot vehement stagnation of the circulation of vital energy, large intestine functional activity of QI being not smooth, therefore it is not well to suffer from diarrhoea;The vehement enteron aisle of heat, then burning sensation of the anus aqueous are from big urinal from spilling out, therefore Scanty drak urine, heat are contained and hinder Tianjin therefore thirsty, and body heat, excrement matter are sticky stench.
Dysentery clinically, to have loose bowels be many with assertive evidence, and treatment is when with eliminating evil.Its new this card of sense category is outstanding more, treats with logical Because general for wanting, the product with inducing astrigency antidiarrheal are avoided.Dysentery patient should be noted that the utilization of regulating the qi flowing in the channels promoting circulation of blood, if lower blood is more should to reuse row The product of blood, many persons of purulence preferably reuse qi-regulating drug;The patient that has loose bowels damp and hot ought distinguish, and which rushes down and can stop.
Content of the invention
The technical problem to be solved is for the deficiencies in the prior art, there is provided a kind of new treatment large intestinal damp-heat The Chinese medicine of card, with pure natural Chinese herbal medicine as raw material, treats both principal and secondary aspect of disease, and determined curative effect, has no toxic side effect, and is difficult to recur.
The technical problem to be solved is realized by following technical scheme.One kind treats large intestinal damp-heat The Chinese medicine of card, is by Chinese herbal medicine semen momordicae, phoenix-tail fern, yncaria stem with hooks, bamboo honeybee, lucid asparagus, water chestnut, propolis, persimmon sugar, flying apsaras, green grass or young crops Black pigment used by women in ancient times to paint their eyebrows, bicolor, sweet wormwood, the seed of feather cockscomb, radix ampelopsis, Radix Rhapontici seu Radix Echinopsis, sheep hoof, Asian puccoon, Radix picrorrhizae composition.
Single dose dose be 12 g of semen momordicae, 8 g of phoenix-tail fern, 15 g of yncaria stem with hooks, 5 g of bamboo honeybee, 10 g of lucid asparagus, 15 g of water chestnut, 5 g of propolis, 3 g of persimmon sugar, 5 g of flying apsaras, 8 g of indigo naturalis, 15 g of bicolor, 8 g of sweet wormwood, 15 g of the seed of feather cockscomb, 12 g of radix ampelopsis, leakage 12 g of reed, 20 g of sheep hoof, 8 g of Asian puccoon, Radix picrorrhizae 10g.
Prepare and instructions of taking:It is decocted in water for oral dose, one daily, divide sooner or later one after each meal twice, be within 7 days a course for the treatment of.
The pharmacological action of each Chinese medicine
Semen momordicae:Dispersing swelling and dissipating binds, toxic removing, cure mainly carbuncle swells, furunculosis, scrofula, hemorrhoid, nameless sores or boils, tinea sore, arthralgia due to wind-dampness, tendon and vessel Contraction;Phoenix-tail fern:Clearing heat and promoting diuresis, cooling blood and hemostasis, subdhing swelling and detoxicating, cure mainly icteric hepatitis, enteritis, bacillary dysentery, stranguria with turbid discharge, under band, tell Blood, bleeding from five sense organs or subcutaneous tissue, have blood in stool, hematuria, tonsillitis, parotitis, carbuncle sore tumefacting virus, eczema;Yncaria stem with hooks:The flat liver of heat-clearing, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion, cures mainly little Youngster's frightened epilepsy, adult's slight Hypertension, dizziness, dizzy, married woman's eclampsia;Bamboo honeybee:Clearing heat and eliminating phlegm, arresting convulsion, cure mainly child convulsion, mouth Sore, pharyngalgia;Lucid asparagus:Enriching yin, moisturize, clearing lung-heat, fall fire, cure mainly fever due to yin deficiency, cough haematemesis, consumptive lung disease, lung carbuncle, abscess of throat, Quench one's thirst, constipation;Water chestnut:Heat-clearing, resolving sputum, disappear product, cure mainly angry disease quench one's thirst, jaundice, heat gonorrhea, mass in the abdomen, hot eyes, chew larynx swell and ache, wart; Propolis:Control corn, hydrazine Zhi, wart and verruca vulgaris, cure mainly malignant tumour and wound effectively, protection granulation tissue, heal beneficial to wound Close, to chap also effective in cure;Persimmon sugar:Heat-clearing, moisturize, resolving sputum, cure mainly lung-heat type cough, dry throat laryngalgia, aphthae, spit blood, cough up Blood, quench one's thirst;Flying apsaras:Clearing lung-heat stomach energy, dispelling wind and eliminating dampness, cure mainly influenza, lung heat cough and asthma, haematemesis, acute toothache, Fengshi Guanjie Bitterly, pain in the back;Consumer edema, cure mainly women red collapse, leukorrhea, malignant boil Huang, damage and synthetism;Indigo naturalis:Heat-clearing, cool blood, removing toxic substances, cure mainly warm disease Hot Sheng, macula, haematemesis, spitting of blood, pediatric epilepsy scared, sore swells, erysipelas, snake bite and insect sting;Bicolor:Clearing heat and detoxicating, blood stasis removing analgesic, cures mainly Upper sense, tonsillitis, acute angina, diphtheria, erysipelas, lymphnoditis, over-strained hemoptysis, heart peratodynia, treating rheumatic ostealgia, bruise are damaged Wound;Sweet wormwood:Heat-clearing, relieving summer-heat, except steam, cure mainly warm disease, hot summer weather, hectic fever due to yin labor heat, malaria, dysentery, jaundice, scabies, itch;Feather cockscomb Son:Wind-dispelling heat, clearing away the liver-fire, cure mainly red eye, swell pain, hide from view, hypertension, nosebleed epistaxis, skin wind-heat itch, scabies leprosy;Radix ampelopsis:Heat-clearing, solution Poison, dissipating bind, myogenic, pain relieving, cure mainly carbuncle swells, furunculosis, scrofula, scald, a kind of malaria, frightened epilepsy, bloody flux, intestines wind, anal fistula;Radix Rhapontici seu Radix Echinopsis:Heat-clearing Removing toxic substances, detumescence and apocenosis, lower breast, logical tendon and vessel, cure mainly ulcer carbuncle on the back, mastosis, alactation, scrofula evil sore, arthritis with fixed pain caused by dampness tendon and vessel and arrest Lead, arthralgia, toxic-heat and blood stasis, hemorrhoid hemorrhage;Sheep hoof:Heat-clearing, defaecation, Li Shui, hemostasis, desinsection, cure mainly dry feces, pouring Turbid, jaundice, haematemesis, intestines wind, functional uterine bleeding, the favus of the scalp, mange, carbuncle swells, traumatic injury, clearing heat and detoxicating, desinsection are antipruritic, logical Just;Asian puccoon:Cool blood, promoting blood circulation, removing toxic substances promoting eruption, be used for blood-heat and toxin exuberance, atropurpureus macula, measles without adequate eruption, sore, eczema, scald; Radix picrorrhizae:Heat-clearing, cool blood, eliminating dampness, cure mainly the hot hectic fever due to yin of infantile malnutrition due to digestive disturbances or intestinalparasites disease, frightened epilepsy, rush down dysentery, labor, spontaneous perspiration, night sweat, haematemesis, bleeding from five sense organs or subcutaneous tissue, pinkeye, hemorrhoid Fistula, sore.
Compared with prior art, the present invention treats both principal and secondary aspect of disease with pure natural Chinese herbal medicine as raw material, determined curative effect, nontoxic pair Effect, is difficult to recur.
Specific embodiment
Chinese herbal medicine proportioning:12 g of semen momordicae, 8 g of phoenix-tail fern, 15 g of yncaria stem with hooks, 5 g of bamboo honeybee, 10 g of lucid asparagus, 15 g of water chestnut, 5 g of propolis, 3 g of persimmon sugar, 5 g of flying apsaras, 8 g of indigo naturalis, 15 g of bicolor, 8 g of sweet wormwood, 15 g of the seed of feather cockscomb, 12 g of radix ampelopsis, leakage 12 g of reed, 20 g of sheep hoof, 8 g of Asian puccoon, Radix picrorrhizae 10g.
Prepare and instructions of taking:It is decocted in water for oral dose, one daily, divide sooner or later one after each meal twice, be within 7 days a course for the treatment of.

Claims (2)

1. a kind of Chinese medicine for treating syndrome of dampness-heat in large intestine, it is characterised in that:Chinese medicinal component is semen momordicae 5-15, phoenix-tail fern 5-15, hook Rattan 10-20, bamboo honeybee 1-10, lucid asparagus 5-15, water chestnut 10-20, propolis 1-10, persimmon sugar 1-5, flying apsaras 1-10, indigo naturalis 5-15, Bicolor 10-20, sweet wormwood 5-15, seed of feather cockscomb 10-20, radix ampelopsis 5-15, Radix Rhapontici seu Radix Echinopsis 5-15, sheep hoof 10-30, Asian puccoon 5-15, Radix picrorrhizae 5-15.
2. a kind of Chinese medicine for treating syndrome of dampness-heat in large intestine according to claim 1, it is characterised in that:The weight portion of each taste medicine is matched somebody with somebody Than for 12 g of semen momordicae, 8 g of phoenix-tail fern, 15 g of yncaria stem with hooks, 5 g of bamboo honeybee, 10 g of lucid asparagus, 15 g of water chestnut, 5 g of propolis, persimmon sugar 3 G, 5 g of flying apsaras, 8 g of indigo naturalis, 15 g of bicolor, 8 g of sweet wormwood, 15 g of the seed of feather cockscomb, 12 g of radix ampelopsis, 12 g of Radix Rhapontici seu Radix Echinopsis, sheep hoof 20 G, 8 g of Asian puccoon, Radix picrorrhizae 10g.
CN201611211756.6A 2016-12-25 2016-12-25 A kind of Chinese medicine for treating syndrome of dampness-heat in large intestine CN106491937A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1579455A (en) * 2003-08-01 2005-02-16 张坚力 Composition of traditional Chinese medicine for large intestine hygropyretic disease and its preparation method
CN101934025A (en) * 2010-08-18 2011-01-05 赵全会 Traditional Chinese medicine for clearing away heat and toxic material
CN102579776A (en) * 2012-03-13 2012-07-18 王建友 Large intestine channel Chinese medicinal oral liquid
CN104324291A (en) * 2014-11-17 2015-02-04 青岛恒波仪器有限公司 Traditional Chinese medicine preparation for treating large intestine damp-heat type hemafecia and preparation method of traditional Chinese medicine preparation
CN105582048A (en) * 2016-01-01 2016-05-18 成都倍加特生物科技有限公司 Medicine for treating diarrhea and haemorrhoid bleeding caused by large intestinal dampness-heat

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1579455A (en) * 2003-08-01 2005-02-16 张坚力 Composition of traditional Chinese medicine for large intestine hygropyretic disease and its preparation method
CN101934025A (en) * 2010-08-18 2011-01-05 赵全会 Traditional Chinese medicine for clearing away heat and toxic material
CN102579776A (en) * 2012-03-13 2012-07-18 王建友 Large intestine channel Chinese medicinal oral liquid
CN104324291A (en) * 2014-11-17 2015-02-04 青岛恒波仪器有限公司 Traditional Chinese medicine preparation for treating large intestine damp-heat type hemafecia and preparation method of traditional Chinese medicine preparation
CN105582048A (en) * 2016-01-01 2016-05-18 成都倍加特生物科技有限公司 Medicine for treating diarrhea and haemorrhoid bleeding caused by large intestinal dampness-heat

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Application publication date: 20170315