CN108969589A - A kind of Chinese medicine composition and preparation method thereof for preventing and treating chicken colibacillosis - Google Patents
A kind of Chinese medicine composition and preparation method thereof for preventing and treating chicken colibacillosis Download PDFInfo
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Abstract
The present invention provides a kind of Chinese medicine composition for preventing and treating chicken colibacillosis, is made of the raw material of following parts by weight: 3-6 parts of the Chinese bulbul, 2-5 parts of Cortex Phellodendri, 3-6 parts of sweet wormwood, 3-6 parts of the bark of ash, 2-5 parts of cape jasmine.Prescription of the present invention is made of this five kinds of medicinal materials of the Chinese bulbul, Cortex Phellodendri, sweet wormwood, the bark of ash and cape jasmine, the Chinese bulbul, Cortex Phellodendri and the bark of ash therein are three taste medicinal materials in the prescription " baitouweng decoction " of classic treatment diarrhea, sweet wormwood and cape jasmine are added again, sweet wormwood, it is bitter, cold, enter liver, gallbladder channel, there are heat-clearing and clearing heat and eliminating dampness, cape jasmine is bitter, cold, enters the heart, liver, lung, stomach meridian, can clear three coke fire and benefit liver and gallbladder damp-heat；The present invention is directed to reduce chicken house because of the incidence and the death rate of diarrhea caused by colibacillosis, prevention and treatment domestic animals and fowls reduce the economic loss of farm, improve the production performance of animal because of diarrhea caused by Escherichia coli.
Description
Technical field
The invention belongs to technical field of veterinary, and in particular to it is a kind of prevent and treat chicken colibacillosis Chinese medicine composition and
Preparation method.
Background technique
Chicken colibacillosis is the pathogenic escherichia coli by certain serotypes, biography caused by abbreviation Escherichia coli
It catches an illness.Chicken colibacillosis can fall ill in the chicken of each age in days, be occurred especially with chick and middle chicken in the majority.Clinical manifestation is a variety of diseases
Type, more typical has septicemia, enteritis, granuloma, pericarditis etc., clinically main to show yellow green watery stools of having loose bowels, most
Afterwards mostly with extreme dehydration, weak and dead, chicken colibacillosis disease incidence and lethality are relatively high, have become chicken growth by
One of the main reason for resistance and high mortality, the loss of tremendous economic is brought to poultry husbandry.Currently to animal large intestine bacillosis
There are also many problems demands to solve for prevention and treatment, is firstly because that enteropathogenic E. Coli serotype is numerous, and there is presently no good
Vaccine can prevention and control, and some chicken farms environmental construction and feeding and management level it is high not enough, this is very advantageous in large intestine bar
The generation and propagation of bacterium disease.
Some antibiotic and chemical antibacterials are mainly leaned on for the treatment of colibacillosis at present, but Escherichia coli are not
Drug resistance is only easily generated, and generates hazardous drugs residual and endangers food safety.Chinese medicine compound prescription is that tcm clinical practice is cured the disease use
The principal mode and means of medicine, embody the characteristic of Chinese medicine Overall View and dialectical treatmert, and compound Chinese herb is managed according to Chinese veterinarian
It is made by by scientific composition compatibility, there are good effect, and the originals such as medicament residue and toxic side effect are small, and environmental pollution is small
Because of the favor increasingly by vast herding worker.
Summary of the invention
The purpose of the present invention is to solve the above-mentioned problems of the prior art, provide a kind of prevention and treatment chicken colibacillosis
Chinese medicine composition.
To achieve the above object, the present invention adopts the following technical scheme: a kind of Chinese traditional medicine composition for preventing and treating chicken colibacillosis
Object is made of the raw material of following parts by weight: 3-6 parts of the Chinese bulbul, 2-5 parts of Cortex Phellodendri, 3-6 parts of sweet wormwood, 3-6 parts of the bark of ash, cape jasmine 2-5
Part.
The preparation method of the Chinese medicine composition of above-mentioned prevention and treatment chicken colibacillosis, comprising the following steps: claim by weight respectively
This five kinds of medicinal materials of the Chinese bulbul, Cortex Phellodendri, sweet wormwood, the bark of ash and cape jasmine are taken, the water that 10 times of medicinal material amounts are first added impregnates 20-40 min, so
60 min are extracted in heating and refluxing extraction 3 times afterwards after boiling every time, and extracting solution three times is merged；Combined extracting solution is concentrated,
It is finally concentrated to containing crude drug amount be 1.2-1.6 g/mL；Ethyl alcohol is added and carries out alcohol precipitation, 2-6 DEG C overnight, filters to obtain supernatant, on
Clear liquid is added auxiliary material and oral solution is made.
The ethyl alcohol volumetric concentration is 60-80%.
The dehydrated alcohol that the propylene glycol and volumetric concentration that the auxiliary material is volumetric concentration 3-6% are 1-4%.
Each effective component of the present invention has the advantage that be with beneficial effect:
The Chinese bulbul: bitter, it is cold in nature, return stomach, large intestine channel.First recorded in Shennong's Herbal.Clearing heat and cooling blood, removing toxic substances.Toxic-heat and blood stasis is controlled,
A kind of malaria fever and chills, nosebleed epistaxis, bleeding.Li Gao: Zhang Zhongjing controls under hot dysentery weight, with baitouweng decoction master it, lid kidney is intended to hard, and anxious food hardship is with heavily fortified point
It, dysentery is then lower burnt empty, therefore with the agent heavily fortified point of pure hardship.Man's yin hernia swelling and hanging down of either of the testes, the bald raw meat of having a strong smell of children, nosebleed epistaxis are not imitated without this, and fulminant dysentery has
This obtains function." book on Chinese herbal medicine is looked for the truth ": the Chinese bulbul, how with this to control a kind of malaria fever and chills, dentalgia, ostalgia, nosebleed epistaxis, the favus of the scalp, the diseases such as hernia lump in the abdomen；Also
Because evil inactivity of yang-qi is bright, it is clear to take this thermal detoxification, and then the not dry bone of disturbing of kidney is solid, stomach not by heresy and tooth is pacified, poison not on invade and be only defeated in battle, heat not in
Knot and hernia and lump in the abdomen all, total all power of removing summer-heat heat toxin.
Cortex Phellodendri: bitter, it is cold in nature, return kidney, bladder meridian.First recorded in Compendium of Material Medica.Heat-clearing and damp-drying drug；Purging fire for removing toxin.Master is damp and hot
Dysentery, diarrhea, jaundice；Nocturnal emission, stranguria with turbid discharge, leukorrhagia；Hectic fever due to yin labor heat；And aphthae；Red eye, swell pain；Skin sore；Skin is wet
Rash." this is through meeting original ": Cortex Phellodendri, raw drop excess fire, wine system control inflammation on yin fire, and salt system controls the inferior the fire of coke, and ginger system controls middle burnt convulsive seizure due to phlegm-fire, ginger
Juice stir-fry is black to control damp and hot, the salt black fire of deficiency type processed parched with wine, and deficiency of Yin fire contains flushing floating yang, monkshood juice system.
Sweet wormwood: acrid flavour, hardship, it is cold in nature, return gallbladder, Liver Channel.First recorded in Shennong's Herbal.Heat-clearing；Relieving summer-heat；Except steaming；Preventing malaria.It is main
Hot summer weather；Summer-heat and damp；Damp-warm syndrome；Fever due to yin deficiency；Malaria；Jaundice." Chongqing hall random notes ": sweet wormwood specially solves damp and hot, and gas is fragrant, therefore is wet
Warm plague key medicine.It clears liver again, the latent heat of gallbladder blood system, therefore drenches band, children's convulsion epilepsy infantile malnutrition due to digestive disturbances or intestinalparasites NI mind agent for woman, " book on Chinese herbal medicine " is not sayed, specially for
Send out it.
The bark of ash: bitter, it is cold in nature, return gallbladder, Liver Channel.First recorded in Shennong's Herbal.Heat-clearing and damp-drying drug, inducing astrigency, improving eyesight.For heat
Dysentery, diarrhea, leukorrhea with reddish discharge, red eye, swell pain, raw screen film of mesh." collected statements on the herbal foundation ": the bark of ash, bitter is puckery and hard, can restrain and wander away it
Vital essence.Therefore Zhong Jing baitouweng decoction, burnt abnormal heat is controled the inferior and benefit person with this, is taken bitter with puckery meaning.Stop man's essence in " Bie Lu " side
Void, married woman collapse band；The diseases such as small youngster shies Epilepsy body heat and the hot mesh of liver is dark, and screen hot eyes is swollen, and wind tear is more than are controlled again in the side Zhen Shi；All edge liver and gallbladder
The strongly fragrant gas of fire dissipates so that disease distinguishes foul smell, air-dispersing convergence with the object of this clear cold clear green decline.Therefore ophthalmology is controlled, screen film is moved back, tear is received
Out；Married woman section is controlled, fixed five collapse, tourniquet；Generous section is controlled, only empty dysentery, holds back spermatorrhea；Control paediatrics, An Jing Epilepsy, regression heat of evaporation.
Cape jasmine: bitter, cold in nature, Gui Sanjiao, the heart, lung channel.First recorded in " Bencao Tujing ".Heat-clearing, purging intense heat, cool blood.Control pyreticosis
Restlessness of asrhenia type and insomnia, jaundice, stranguria syndrome are quenched one's thirst, hot eyes, pharyngalgia, are spitted blood, bleeding from five sense organs or subcutaneous tissue, bloody flux, hematuria, and pathopyretic ulcer sprains swelling and pain." the legendary god of farming
Book on Chinese herbal medicine warp ": bitter is trembled with fear.Cure mainly perverse trend in five, pathogenic heat in the stomach gas, flushing rosacea, white leprosy, red leprosy, sore.
Prescription of the present invention is made of this five kinds of medicinal materials of the Chinese bulbul, Cortex Phellodendri, sweet wormwood, the bark of ash and cape jasmine, the Chinese bulbul therein, Huang
Cypress and the bark of ash are three taste medicinal materials in the prescription " baitouweng decoction " of classic treatment diarrhea, and add sweet wormwood and cape jasmine, sweet wormwood, bitter,
It is cold, enter liver, gallbladder channel, there is heat-clearing and clearing heat and eliminating dampness, cape jasmine is bitter, cold, enter the heart, liver, lung, stomach meridian, can clear three coke it is fiery simultaneous
Sharp liver and gallbladder damp-heat；The present invention is the pathological effects experimental study according to Chinese veterinarian's theory and drug, and combines production reality, is matched
The new Chinese medicine compound prescriptions of one kind of 5 compositions, it is intended to reduce chicken house because of the incidence and the death rate of diarrhea caused by colibacillosis,
Domestic animals and fowls are prevented and treated because of diarrhea caused by Escherichia coli, the economic loss of farm is reduced, improves the production performance of animal.
Specific embodiment
The present invention is further explained in the light of specific embodiments.
Embodiment 1
The Chinese medicine composition of the present embodiment prevention and treatment chicken colibacillosis is made of the raw material of following parts by weight: 60 g of the Chinese bulbul, Cortex Phellodendri
40 g, 60 g of sweet wormwood, 60 g of the bark of ash, 30 g of cape jasmine.
Preparation method: this five kinds of medicinal materials of the Chinese bulbul, Cortex Phellodendri, sweet wormwood, the bark of ash and cape jasmine are weighed by weight respectively, are first added
10 times of amount water of medicinal material impregnate 30 min, 60 min are extracted in then heating and refluxing extraction 3 times after boiling every time, will three times
Extracting solution merges；Combined extracting solution is concentrated, is finally concentrated to containing crude drug amount be 1.4 g/mL；Ethyl alcohol is added and carries out alcohol precipitation, second
Alcohol volumetric concentration is 75%, and 4 DEG C overnight, filters to obtain supernatant, and supernatant is added auxiliary material and oral solution is made, and auxiliary material is added are as follows: volume
The propylene glycol that concentration is 5%, the dehydrated alcohol that volumetric concentration is 3%.
Embodiment 2
The Chinese medicine composition of the present embodiment prevention and treatment chicken colibacillosis is made of the raw material of following parts by weight: 60 g of the Chinese bulbul, Cortex Phellodendri
30 g, 50 g of sweet wormwood, 50 g of the bark of ash, 50 g of cape jasmine.
Preparation method: this five kinds of medicinal materials of the Chinese bulbul, Cortex Phellodendri, sweet wormwood, the bark of ash and cape jasmine are weighed by weight respectively, are first added
10 times of amount water of medicinal material impregnate 20 min, 60 min are extracted in then heating and refluxing extraction 3 times after boiling every time, will three times
Extracting solution merges；Combined extracting solution is concentrated, is finally concentrated to containing crude drug amount be 1.3 g/mL；Ethyl alcohol is added and carries out alcohol precipitation, second
Alcohol volumetric concentration is 60%, and 2 DEG C overnight, filters to obtain supernatant, and supernatant is added auxiliary material and oral solution is made, and auxiliary material is added are as follows: volume
The propylene glycol that concentration is 3%, the dehydrated alcohol that volumetric concentration is 1%.
Embodiment 3
The Chinese medicine composition of the present embodiment prevention and treatment chicken colibacillosis is made of the raw material of following parts by weight: 50 g of the Chinese bulbul, Cortex Phellodendri
50 g, 40 g of sweet wormwood, 60 g of the bark of ash, 40 g of cape jasmine.
Preparation method: this five kinds of medicinal materials of the Chinese bulbul, Cortex Phellodendri, sweet wormwood, the bark of ash and cape jasmine are weighed by weight respectively, are first added
10 times of amount water of medicinal material impregnate 40 min, 60 min are extracted in then heating and refluxing extraction 3 times after boiling every time, will three times
Extracting solution merges；Combined extracting solution is concentrated, is finally concentrated to containing crude drug amount be 1.6 g/mL；Ethyl alcohol is added and carries out alcohol precipitation, second
Alcohol volumetric concentration is 80%, and 6 DEG C overnight, filters to obtain supernatant, and supernatant is added auxiliary material and oral solution is made, and auxiliary material is added are as follows: volume
The propylene glycol that concentration is 6%, the dehydrated alcohol that volumetric concentration is 4%.
Embodiment 4
The Chinese medicine composition of the present embodiment prevention and treatment chicken colibacillosis is made of the raw material of following parts by weight: 40 g of the Chinese bulbul, Cortex Phellodendri
20 g, 50 g of sweet wormwood, 40 g of the bark of ash, 30 g of cape jasmine.
Preparation method: this five kinds of medicinal materials of the Chinese bulbul, Cortex Phellodendri, sweet wormwood, the bark of ash and cape jasmine are weighed by weight respectively, are first added
10 times of amount water of medicinal material impregnate 25 min, 60 min are extracted in then heating and refluxing extraction 3 times after boiling every time, will three times
Extracting solution merges；Combined extracting solution is concentrated, is finally concentrated to containing crude drug amount be 1.2 g/mL；Ethyl alcohol is added and carries out alcohol precipitation, second
Alcohol volumetric concentration is 65%, and 5 DEG C overnight, filters to obtain supernatant, and supernatant is added auxiliary material and oral solution is made, and auxiliary material is added are as follows: volume
The propylene glycol that concentration is 4%, the dehydrated alcohol that volumetric concentration is 2%.
Embodiment 5
The Chinese medicine composition of the present embodiment prevention and treatment chicken colibacillosis is made of the raw material of following parts by weight: 30 g of the Chinese bulbul, Cortex Phellodendri
50 g, 30 g of sweet wormwood, 30 g of the bark of ash, 50 g of cape jasmine.
Preparation method: this five kinds of medicinal materials of the Chinese bulbul, Cortex Phellodendri, sweet wormwood, the bark of ash and cape jasmine are weighed by weight respectively, are first added
10 times of amount water of medicinal material impregnate 35 min, 60 min are extracted in then heating and refluxing extraction 3 times after boiling every time, will three times
Extracting solution merges；Combined extracting solution is concentrated, is finally concentrated to containing crude drug amount be 1.5 g/mL；Ethyl alcohol is added and carries out alcohol precipitation, second
Alcohol volumetric concentration is 70%, and 3 DEG C overnight, filters to obtain supernatant, and supernatant is added auxiliary material and oral solution is made, and auxiliary material is added are as follows: volume
The propylene glycol that concentration is 3%, the dehydrated alcohol that volumetric concentration is 3%.
Embodiment 6
The Chinese medicine composition of the present embodiment prevention and treatment chicken colibacillosis is made of the raw material of following parts by weight: 30 g of the Chinese bulbul, Cortex Phellodendri
30 g, 60 g of sweet wormwood, 50 g of the bark of ash, 20 g of cape jasmine.
Preparation method: this five kinds of medicinal materials of the Chinese bulbul, Cortex Phellodendri, sweet wormwood, the bark of ash and cape jasmine are weighed by weight respectively, are first added
10 times of amount water of medicinal material impregnate 30 min, 60 min are extracted in then heating and refluxing extraction 3 times after boiling every time, will three times
Extracting solution merges；Combined extracting solution is concentrated, is finally concentrated to containing crude drug amount be 1.4 g/mL；Ethyl alcohol is added and carries out alcohol precipitation, second
Alcohol volumetric concentration is 75%, and 4 DEG C overnight, filters to obtain supernatant, and supernatant is added auxiliary material and oral solution is made, and auxiliary material is added are as follows: volume
The propylene glycol that concentration is 5%, the dehydrated alcohol that volumetric concentration is 3%.
It extracts invention formula Chinese medicine effective component and is processed into oral solution, content specification: 1 mL final drug is equivalent to
1 g of crude drug.
Purposes: prevention and treatment chicken colibacillosis.
Administration route: (mixed feeding, gavages mixed drink) for oral administration.
It further proves below by way of experiment of the invention, plus-minus baitouweng decoction is named as to the present invention in following tests.
1, influence of the plus-minus baitouweng decoction to the death rate of the chicken of ehec infection disease
Health of the experimental animal selected for same henhouse, the uniform 30 age in days chicken of weight 160, half male and half female collocation are divided into
Four groups, every group 40, respectively blank control group, Escherichia coli group, prophylactic agent group and therapeutic agent group.Three groups of processing modes
As follows: blank control group normally feeds and is not processed；Escherichia coli group gives coli-infection, normal to feed；Prophylactic agent
Group is then mixed with Chinese medicinal formulae plus-minus baitouweng decoction before giving coli-infection in daily feeding daily ration, once a day,
1 mL/ only, feeding with medicine 7 days；Therapeutic agent group is mixed with this in daily feeding daily ration after then giving coli-infection
Chinese medicinal formulae adds and subtracts baitouweng decoction, once a day, 1 mL/ only, feeding with medicine 7 days.Four groups of chickens are observed in 30 days,
There is spiritual extremely depressed, feather pine in 16 ~ 20 h after observation discovery infection, the chicken of the Escherichia coli group of ehec infection
Disorderly, necking down is closed one's eyes, and is reluctant to walk about, and is peeled off slow-witted vertical or is kept down, phenomena such as laxativeness and successively death occur in some diseased chickens.System
Four groups of disease incidence and the death rate are counted, as a result such as following table one.
Table one adds and subtracts influence of the baitouweng decoction to the death rate of the chicken of ehec infection disease
2, inhibiting effect of the plus-minus baitouweng decoction to different serotypes Escherichia coli
80 plants of Escherichia coli are isolated from the chicken group of chicken house natural infection Escherichia coli, are belonging respectively to O1、O2、O45、O74、O78、
O111This six kinds of serotypes, plus-minus baitouweng decoction has bacteriostasis to these types of Escherichia coli, as a result such as following table two.
Table two adds and subtracts baitouweng decoction to the inhibiting effect of different serotypes Escherichia coli
The above be the preferred embodiment of the present invention, it is noted that for those skilled in the art, the present invention not by
The limitation of above-described embodiment can also make several changes and improvements under the premise of not departing from general idea of the present invention, these
Also it should be considered as protection scope of the present invention.
Claims (4)
1. a kind of Chinese medicine composition for preventing and treating chicken colibacillosis, it is characterised in that: be made of the raw material of following parts by weight: hoary hair
3-6 parts of father-in-law, 2-5 parts of Cortex Phellodendri, 3-6 parts of sweet wormwood, 3-6 parts of the bark of ash, 2-5 parts of cape jasmine.
2. a kind of method for the Chinese medicine composition for preparing prevention and treatment chicken colibacillosis as described in claim 1, it is characterised in that: packet
It includes following steps: weighing this five kinds of medicinal materials of the Chinese bulbul, Cortex Phellodendri, sweet wormwood, the bark of ash and cape jasmine by weight respectively, medicinal material 10 is first added
The water of amount impregnates 20-40 min again, and 60 min are extracted in then heating and refluxing extraction 3 times after boiling every time, by extraction three times
Liquid merges；Combined extracting solution is concentrated, is finally concentrated to containing crude drug amount be 1.2-1.6 g/mL；Ethyl alcohol is added and carries out alcohol precipitation, 2-6
DEG C overnight, supernatant is filtered to obtain, supernatant is added auxiliary material and oral solution is made.
3. the preparation method of the Chinese medicine composition of prevention and treatment chicken colibacillosis as claimed in claim 2, it is characterised in that: the second
Alcohol volumetric concentration is 60-80%.
4. the preparation method of the Chinese medicine composition of prevention and treatment chicken colibacillosis as claimed in claim 2, it is characterised in that: described auxiliary
Material is the propylene glycol that volumetric concentration is 3-6% and the dehydrated alcohol that volumetric concentration is 1-4%.
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| CN (1) | CN108969589A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396462A (en) * | 2007-09-30 | 2009-04-01 | 天津瑞普生物技术集团有限公司 | Traditional Chinese medicine oral liquid for treating livestock and poultry digestive canal disease |
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2018
- 2018-10-30 CN CN201811276832.0A patent/CN108969589A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396462A (en) * | 2007-09-30 | 2009-04-01 | 天津瑞普生物技术集团有限公司 | Traditional Chinese medicine oral liquid for treating livestock and poultry digestive canal disease |
Non-Patent Citations (1)
| Title |
|---|
| 周国梁等: "黄连解毒汤拆方体外抑菌试验研究", 《中兽医医药杂志》 * |
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Application publication date: 20181211 |
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