CN104256096A - Feed additive and feed for treating piglet diarrhea - Google Patents
Feed additive and feed for treating piglet diarrhea Download PDFInfo
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- CN104256096A CN104256096A CN201410524343.8A CN201410524343A CN104256096A CN 104256096 A CN104256096 A CN 104256096A CN 201410524343 A CN201410524343 A CN 201410524343A CN 104256096 A CN104256096 A CN 104256096A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention provides feed for treating the piglet diarrhea. Raw materials of the feed comprise maize, soybean meal, fish meal, calcium hydrophosphate, edible salts, a Chinese medicinal additive for treating the piglet diarrhea, a vitamin premix, serine, glutamic acid, glycine, copper sulfate and zinc sulfate. The feed has the advantages of good effect, quick response, strong stability, and no drug resistance, resisting drug or drug residue, and is a pollution-free product.
Description
Technical field
The present invention relates to field of feed, particularly relate to a kind of feed addictive and the feed that are used for the treatment of piglet diarrhea.
Background technology
Piglet yellow-white dysentery is the abbreviation of piglet yellow scour, dysentery characterized by white mucous stool, usually, within 3-10 days, be yellow dysentery after piglet birth, and be born more than 10 the dysentery characterized by white mucous stool that is called, and also can judge by observing stool colour, the two is all a kind of acute infectious disease being caused newborn piglet by enteropathogenic E. Coli, and being affects piglet to grow and one of main epidemic disease be bred as, and causes great economic loss to pig industry.
Piglet yellow scour, also known as birth colibacillosis of piglet or piglet Early onset colibacillosis, is the one acute height lethal enteric infectious disease of the birth sucking pig within one week age.With diarrhoea, discharge yellow loose stool, acute death is principal character.Common are the pathological change of enteritis and septicemia, M & M is high.The white scour of piglet, also known as delayed colibacillosis, is a kind of acute infectious disease of the piglet long hair of 10-30 age in days, and to drain milky or the canescence loose stool with bad smell for principal character, the incidence of disease is high, the death rate is low, but affects growing of piglet.
It is reported, in U.S.'s newborn piglet diarrhea, 48% by Escherichia coli.For many years, antibiotic and chemotherapeutic agent are that immuning failure rear defence effects a permanent cure the common drug of disease, and have got good effect.But, antibacterials use for a long time and widely, especially unreasonable abuse, lure that resistance phenomenon appears in pathogenic bacteria into, cause many antibacterials to the curative effect of coliform diarrhea in piglets in continuous reduction, how developing high-efficiency low-toxicity, the medicine of low-residual, low drug resistance has become prevents and treats coliform diarrhea in piglets problem in the urgent need to address.
Chinese herbal feed additive has multiple nutritional components and biologically active, have nutrition and medicament dual effect concurrently, not only can disease preventing and treating but also can production performance be improved, not only can directly antibacterial and sterilization, the immunologic function of body can also be regulated, there is nospecific immunity antibacterial action.Chinese herbal feed additive, not only containing sugar, the nutritional labeling needed for animal body such as fat, amino acid, vitamin, trace element, also contains the bioactivators such as alkaloids, glucoside, volatile oil, pigment.These bioactivators have enhancing immunity, resisting stress, adjustment metabolism, improve the effect such as meat and carcass trait.Some Chinese herbal medicine has the effect that the functional status (hyperfunction or suppression) to a certain internal organs of animal adjusts.
What traditional Chinese veterinary medicine thought piglet yellow-white dysentery is because of piglet congenital malformation, subalimentation, will cause the weakness of the spleen and the stomach and resistance of piglet to decline the day after tomorrow, and the hot poison of summer-heat and damp is taken advantage of a weak point stomach, cause the digestion and absorption function obstacle of taste, be unable to distinguish between the clear and the muddy, mix and under, form and have loose bowels, or in malicious stagnant intestines, enteron aisle qi and blood is blocked, turns to purulence white, therefore diarrhea look white or band purulence is white.Wherein the white scour of piglet can be divided into hygropyretic dysentery and cold of insufficiency type dysentery two class, and Chinese veterinarian thinks that the skin infections of newborn infants cross Sheng, and heat breast hindered, and sow overfeeding or feed sudden change, there was an abrupt change in weather, and fever and chills invasion and attack etc. also can cause the generation of this disease.
Chinese herbal feed additive, as " green " additive of a kind of pure natural, can avoid above-mentioned shortcoming, be one both without the resistance to the action of a drug and drug resistance, also, free of contamination class natural prodcuts residual without poisoning.Chinese herbal medicine can eliminate the negative effect such as medicament residue, drug resistance that antibiotic exists in use, and has that drug residue is low, toxic and side effect is little, not easily produces the advantages such as drug resistance.Lot of experiments research shows, application Chinese herbal and crude drugs preparations control piglet yellow-white dysentery is feasible, has achieved certain achievement in research, and have definite theoretical foundation with Chinese herbal and crude drugs preparations prevention and therapy piglet yellow-white dysentery.But, although Chinese herbal treatment scheme known at present has certain result for the treatment of, but still there is the defects such as drug effect is slow, unstable.The present invention based on Chinese veterinarian's therapy theory, follow replenish qi to invigorate the spleen, the principle that clearing heat and detoxicating, anti-inflammatory is degerming, a kind of medicine being used for the treatment of piglet diarrhea is provided, its good effect, instant effect, stability is strong, have no drug resistance and antiradiation drug, remaining without key, is free of contamination product.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of medicine and the feed that are used for the treatment of piglet diarrhea, and it is effective, instant effect, and stability is strong, has no drug resistance and antiradiation drug, and remaining without key, is free of contamination product.
For solving the problems of the technologies described above, the invention provides a kind of feed being used for the treatment of piglet diarrhea, its raw material comprises corn, dregs of beans, fish meal, calcium monohydrogen phosphate, salt, the Chinese herbal feed additive being used for the treatment of piglet diarrhea, vitamin premix, serine, glutamic acid, glycine, copper sulphate and zinc sulfate.
Wherein, in described feed, the weight portion of each raw material is respectively corn 65 weight portion ~ 70 weight portion, dregs of beans 25 weight portion ~ 30 weight portion, fish meal 8 weight portion ~ 12 weight portion, calcium monohydrogen phosphate 2 weight portion ~ 4 weight portion, salt 1 weight portion ~ 3 weight portion, be used for the treatment of Chinese herbal feed additive 0.5 weight portion ~ 1.5 weight portion of piglet diarrhea, vitamin premix 0.2 weight portion ~ 0.4 weight portion, serine 0.05 weight portion ~ 0.15 weight portion, glutamic acid 0.05 weight portion ~ 0.15 weight portion, glycine 0.05 weight portion ~ 0.15 weight portion, copper sulphate 0.05 weight portion ~ 0.15 weight portion and zinc sulfate 0.05 weight portion ~ 0.15 weight portion.
Wherein, in described feed, the weight portion of each raw material is respectively corn 68 weight portion, dregs of beans 28 weight portion, fish meal 10 weight portion, calcium monohydrogen phosphate 3 weight portion, salt 2 weight portion, Chinese herbal feed additive 1 weight portion being used for the treatment of piglet diarrhea, vitamin premix 0.3 weight portion, serine 0.1 weight portion, glutamic acid 0.1 weight portion, glycine 0.1 weight portion, copper sulphate 0.1 weight portion and zinc sulfate 0.1 weight portion.
Wherein, the bulk drug of described medicated feed additive comprises Swertia patens, wolf's milk, nutmeg, tarragon, the fruit of Chinese magnoliavine, Fructus Hordei Germinatus, purslane, wilsonii, the stem of noble dendrobium, felwort, the red sage root, oldenlandia diffusa, subprostrate sophora, the radix paeoniae rubrathe, ardisia japonica, schizonepeta, sweet wormwood, garden burnet, Chinese holly, eclipta, Radix Liriopes, Gorgon fruit, dwarf sheareria herb, rust-coloured crotalaria herb with root and japanese white birch bark.
Wherein, in described medicated feed additive, the weight of each bulk drug is respectively Swertia patens 25 weight portion ~ 35 weight portion, wolf's milk 15 weight portion ~ 25 weight portion, nutmeg 25 weight portion ~ 35 weight portion, tarragon 15 weight portion ~ 25 weight portion, the fruit of Chinese magnoliavine 35 weight portion ~ 45 weight portion, Fructus Hordei Germinatus 15 weight portion ~ 25 weight portion, purslane 25 weight portion ~ 35 weight portion, wilsonii 35 weight portion ~ 45 weight portion, the stem of noble dendrobium 20 weight portion ~ 30 weight portion, felwort 15 weight portion ~ 25 weight portion, the red sage root 20 weight portion ~ 30 weight portion, oldenlandia diffusa 20 weight portion ~ 30 weight portion, subprostrate sophora 25 weight portion ~ 35 weight portion, the radix paeoniae rubrathe 25 weight portion ~ 35 weight portion, ardisia japonica 20 weight portion ~ 30 weight portion, schizonepeta 15 weight portion ~ 25 weight portion, sweet wormwood 15 weight portion ~ 25 weight portion, garden burnet 20 weight portion ~ 30 weight portion, Chinese holly 25 weight portion ~ 35 weight portion, eclipta 30 weight portion ~ 40 weight portion, Radix Liriopes 25 weight portion ~ 35 weight portion, Gorgon fruit 25 weight portion ~ 35 weight portion, dwarf sheareria herb 15 weight portion ~ 25 weight portion, rust-coloured crotalaria herb with root 15 weight portion ~ 25 weight portion and japanese white birch bark 15 weight portion ~ 25 weight portion.
Wherein, in described medicine, the weight of each bulk drug is respectively Swertia patens 28 weight portion ~ 32 weight portion, wolf's milk 18 weight portion ~ 22 weight portion, nutmeg 28 weight portion ~ 32 weight portion, tarragon 18 weight portion ~ 22 weight portion, the fruit of Chinese magnoliavine 38 weight portion ~ 42 weight portion, Fructus Hordei Germinatus 18 weight portion ~ 22 weight portion, purslane 28 weight portion ~ 32 weight portion, wilsonii 38 weight portion ~ 42 weight portion, the stem of noble dendrobium 23 weight portion ~ 27 weight portion, felwort 18 weight portion ~ 22 weight portion, the red sage root 23 weight portion ~ 27 weight portion, oldenlandia diffusa 23 weight portion ~ 27 weight portion, subprostrate sophora 28 weight portion ~ 32 weight portion, the radix paeoniae rubrathe 28 weight portion ~ 32 weight portion, ardisia japonica 23 weight portion ~ 27 weight portion, schizonepeta 18 weight portion ~ 22 weight portion, sweet wormwood 18 weight portion ~ 22 weight portion, garden burnet 23 weight portion ~ 27 weight portion, Chinese holly 28 weight portion ~ 32 weight portion, eclipta 33 weight portion ~ 37 weight portion, Radix Liriopes 28 weight portion ~ 32 weight portion, Gorgon fruit 28 weight portion ~ 32 weight portion, dwarf sheareria herb 18 weight portion ~ 22 weight portion, rust-coloured crotalaria herb with root 18 weight portion ~ 22 weight portion and japanese white birch bark 18 weight portion ~ 22 weight portion.
Present invention also offers the preparation method of above-mentioned feed, be specially:
The first step, by wolf's milk, nutmeg, tarragon, the fruit of Chinese magnoliavine, purslane, wilsonii, the stem of noble dendrobium, oldenlandia diffusa, the radix paeoniae rubrathe, ardisia japonica, sweet wormwood, garden burnet, eclipta, Radix Liriopes, Gorgon fruit, dwarf sheareria herb and the mixing of rust-coloured crotalaria herb with root parts by weights, obtain mixture, add determining alcohol be 50% ~ 70% ethanolic solution carry out heating and refluxing extraction 2 times, each refluxing extraction 2h ~ 3h, the amount of the mixture interpolation ethanolic solution of every 1kg is 3L ~ 5L, the extract obtained merges filtration, leave standstill 24h, reclaim ethanol and concentrate, be condensed into thick paste, dry, be ground into the first powder, remaining components parts by weights is mixed, obtains mixture, add the water relative to mixture quality 2 ~ 4 times, carry out decoction process 1 ~ 3 hour, decoction liquor is filtered, obtain the first filtrate, filter residue adds the water relative to original mixture quality 1 ~ 3 times again, carry out decoction process 1 ~ 3 hour, decoction liquor is filtered again, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, reduced pressure concentration removes into thick paste, dry, pulverize into the second powder, by the first powder and the mixing of the second powder, obtain feed addictive,
Second step, pulverizes each interpolation raw material in feed, mixing and stirring, obtains feed.
Present invention also offers a kind of Chinese herbal feed additive being used for the treatment of piglet diarrhea, its bulk drug comprises Swertia patens, wolf's milk, nutmeg, tarragon, the fruit of Chinese magnoliavine, Fructus Hordei Germinatus, purslane, wilsonii, the stem of noble dendrobium, felwort, the red sage root, oldenlandia diffusa, subprostrate sophora, the radix paeoniae rubrathe, ardisia japonica, schizonepeta, sweet wormwood, garden burnet, Chinese holly, eclipta, Radix Liriopes, Gorgon fruit, dwarf sheareria herb, rust-coloured crotalaria herb with root and japanese white birch bark.
Wherein, in described medicated feed additive, the weight of each bulk drug is respectively Swertia patens 25 weight portion ~ 35 weight portion, wolf's milk 15 weight portion ~ 25 weight portion, nutmeg 25 weight portion ~ 35 weight portion, tarragon 15 weight portion ~ 25 weight portion, the fruit of Chinese magnoliavine 35 weight portion ~ 45 weight portion, Fructus Hordei Germinatus 15 weight portion ~ 25 weight portion, purslane 25 weight portion ~ 35 weight portion, wilsonii 35 weight portion ~ 45 weight portion, the stem of noble dendrobium 20 weight portion ~ 30 weight portion, felwort 15 weight portion ~ 25 weight portion, the red sage root 20 weight portion ~ 30 weight portion, oldenlandia diffusa 20 weight portion ~ 30 weight portion, subprostrate sophora 25 weight portion ~ 35 weight portion, the radix paeoniae rubrathe 25 weight portion ~ 35 weight portion, ardisia japonica 20 weight portion ~ 30 weight portion, schizonepeta 15 weight portion ~ 25 weight portion, sweet wormwood 15 weight portion ~ 25 weight portion, garden burnet 20 weight portion ~ 30 weight portion, Chinese holly 25 weight portion ~ 35 weight portion, eclipta 30 weight portion ~ 40 weight portion, Radix Liriopes 25 weight portion ~ 35 weight portion, Gorgon fruit 25 weight portion ~ 35 weight portion, dwarf sheareria herb 15 weight portion ~ 25 weight portion, rust-coloured crotalaria herb with root 15 weight portion ~ 25 weight portion and japanese white birch bark 15 weight portion ~ 25 weight portion.
Beneficial effect of the present invention:
Medicine and the feed being used for the treatment of piglet diarrhea provided by the invention, it is effective, instant effect, and stability is strong, has no drug resistance and antiradiation drug, and remaining without key, is free of contamination product.
Detailed description of the invention
The invention provides a kind of medicine being used for the treatment of piglet diarrhea, it comprises: Swertia patens, wolf's milk, nutmeg, tarragon, the fruit of Chinese magnoliavine, Fructus Hordei Germinatus, purslane, wilsonii, the stem of noble dendrobium, felwort, the red sage root, oldenlandia diffusa, subprostrate sophora, the radix paeoniae rubrathe, ardisia japonica, schizonepeta, sweet wormwood, garden burnet, Chinese holly, eclipta, Radix Liriopes, Gorgon fruit, dwarf sheareria herb, rust-coloured crotalaria herb with root and japanese white birch bark.
Further preferably, described medicine is only made up of above-mentioned raw materials medicine.
Described piglet diarrhea is specially piglet yellow-white dysentery.
In described medicine, the weight of each bulk drug is respectively Swertia patens 25 weight portion ~ 35 weight portion, wolf's milk 15 weight portion ~ 25 weight portion, nutmeg 25 weight portion ~ 35 weight portion, tarragon 15 weight portion ~ 25 weight portion, the fruit of Chinese magnoliavine 35 weight portion ~ 45 weight portion, Fructus Hordei Germinatus 15 weight portion ~ 25 weight portion, purslane 25 weight portion ~ 35 weight portion, wilsonii 35 weight portion ~ 45 weight portion, the stem of noble dendrobium 20 weight portion ~ 30 weight portion, felwort 15 weight portion ~ 25 weight portion, the red sage root 20 weight portion ~ 30 weight portion, oldenlandia diffusa 20 weight portion ~ 30 weight portion, subprostrate sophora 25 weight portion ~ 35 weight portion, the radix paeoniae rubrathe 25 weight portion ~ 35 weight portion, ardisia japonica 20 weight portion ~ 30 weight portion, schizonepeta 15 weight portion ~ 25 weight portion, sweet wormwood 15 weight portion ~ 25 weight portion, garden burnet 20 weight portion ~ 30 weight portion, Chinese holly 25 weight portion ~ 35 weight portion, eclipta 30 weight portion ~ 40 weight portion, Radix Liriopes 25 weight portion ~ 35 weight portion, Gorgon fruit 25 weight portion ~ 35 weight portion, dwarf sheareria herb 15 weight portion ~ 25 weight portion, rust-coloured crotalaria herb with root 15 weight portion ~ 25 weight portion and japanese white birch bark 15 weight portion ~ 25 weight portion.
Further preferably, in described medicine, the weight of each bulk drug is respectively Swertia patens 28 weight portion ~ 32 weight portion, wolf's milk 18 weight portion ~ 22 weight portion, nutmeg 28 weight portion ~ 32 weight portion, tarragon 18 weight portion ~ 22 weight portion, the fruit of Chinese magnoliavine 38 weight portion ~ 42 weight portion, Fructus Hordei Germinatus 18 weight portion ~ 22 weight portion, purslane 28 weight portion ~ 32 weight portion, wilsonii 38 weight portion ~ 42 weight portion, the stem of noble dendrobium 23 weight portion ~ 27 weight portion, felwort 18 weight portion ~ 22 weight portion, the red sage root 23 weight portion ~ 27 weight portion, oldenlandia diffusa 23 weight portion ~ 27 weight portion, subprostrate sophora 28 weight portion ~ 32 weight portion, the radix paeoniae rubrathe 28 weight portion ~ 32 weight portion, ardisia japonica 23 weight portion ~ 27 weight portion, schizonepeta 18 weight portion ~ 22 weight portion, sweet wormwood 18 weight portion ~ 22 weight portion, garden burnet 23 weight portion ~ 27 weight portion, Chinese holly 28 weight portion ~ 32 weight portion, eclipta 33 weight portion ~ 37 weight portion, Radix Liriopes 28 weight portion ~ 32 weight portion, Gorgon fruit 28 weight portion ~ 32 weight portion, dwarf sheareria herb 18 weight portion ~ 22 weight portion, rust-coloured crotalaria herb with root 18 weight portion ~ 22 weight portion and japanese white birch bark 18 weight portion ~ 22 weight portion.
Most preferably, in described medicine, the weight of each bulk drug is respectively Swertia patens 30 weight portion, wolf's milk 20 weight portion, nutmeg 30 weight portion, tarragon 20 weight portion, the fruit of Chinese magnoliavine 40 weight portion, Fructus Hordei Germinatus 20 weight portion, purslane 30 weight portion, wilsonii 40 weight portion, the stem of noble dendrobium 25 weight portion, felwort 20 weight portion, the red sage root 25 weight portion, oldenlandia diffusa 25 weight portion, subprostrate sophora 30 weight portion, the radix paeoniae rubrathe 30 weight portion, ardisia japonica 25 weight portion, schizonepeta 20 weight portion, sweet wormwood 20 weight portion, garden burnet 25 weight portion, Chinese holly 30 weight portion, eclipta 35 weight portion, Radix Liriopes 30 weight portion, Gorgon fruit 30 weight portion, dwarf sheareria herb 20 weight portion, rust-coloured crotalaria herb with root 20 weight portion and japanese white birch bark 20 weight portion.
Present invention also offers the preparation method of said medicine, be specially:
By bulk drug component each in described medicine by above-mentioned weight portion mixing, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, carry out decoction process 1 ~ 3 hour, decoction liquor is filtered, obtain the first filtrate, filter residue adds the water relative to original mixture quality 1 ~ 3 times again, carries out decoction process 1 ~ 3 hour, decoction liquor is filtered again, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, be condensed into the decoction liquor of 0.5g/ml.
Medicine provided by the present invention is also prepared into feed addictive, and its preparation method is specially:
The first step, by wolf's milk, nutmeg, tarragon, the fruit of Chinese magnoliavine, purslane, wilsonii, the stem of noble dendrobium, oldenlandia diffusa, the radix paeoniae rubrathe, ardisia japonica, sweet wormwood, garden burnet, eclipta, Radix Liriopes, Gorgon fruit, dwarf sheareria herb and the mixing of rust-coloured crotalaria herb with root parts by weights, obtain mixture, add determining alcohol be 50% ~ 70% ethanolic solution carry out heating and refluxing extraction 2 times, each refluxing extraction 2h ~ 3h, the amount of the mixture interpolation ethanolic solution of every 1kg is 3L ~ 5L, the extract obtained merges filtration, leave standstill 24h, reclaim ethanol and concentrate, be condensed into thick paste, dry, be ground into the first powder,
Second step, mixes remaining components parts by weights, obtains mixture, add the water relative to mixture quality 2 ~ 4 times, carry out decoction process 1 ~ 3 hour, decoction liquor is filtered, obtain the first filtrate, filter residue adds the water relative to original mixture quality 1 ~ 3 times again, carries out decoction process 1 ~ 3 hour, decoction liquor is filtered again, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, reduced pressure concentration removes into thick paste, dry, pulverize into the second powder;
3rd step, by the first powder and the mixing of the second powder, obtains feed addictive.
The pharmacology of each bulk drug is as follows:
Swertia patens: be the herb of gentianaceae plant knurl hair Swertia patens, bitter, cold in nature, have heat-clearing, stomach invigorating, effect of dampness removing, cures mainly indigestion, gastritis, jaundice, pinkeye, toothache, the cards such as aphtha.
Wolf's milk: taste is pungent, property is put down, return liver, large intestine channel, there is effect that is clearing heat and detoxicating, cooling blood and hemostasis, damp-heat dysentery, urine leaching pain, jaundice, various go out the treatment of blood trouble etc., wolf's milk has effect that is antibacterial or sterilization to staphylococcus aureus, hemolytic streptococcus, corynebacterium diphtheriae, Escherichia coli, shigella dysenteriae etc.
Nutmeg: latin name
myristicae Semen,taste is pungent, bitter, warm in nature, enters spleen, stomach, large intestine channel, cards such as having the effect of puckery intestines, promote qi circulation digestion promoting in temperature, rush down for void, cold dysentery, abdominal distention, food are vomitted less, place food does not disappear.
Tarragon: taste is pungent, bitter, warm in nature, returns liver,spleen,kidney warp, cures mainly haematemesis; Bleeding from five sense organs or subcutaneous tissue; Painstaking blood; Have blood in stool; Uterine bleeding; Gestation hemorrhage; Irregular menstruation; Dysmenorrhoea; Fetal irritability; Trusted subordinate's crymodynia; To have loose bowels protracted dysentery; Choleraic myospasm; Under band; Eczema; Mange; Hemorrhoid; The cards such as large carbuncle.
The fruit of Chinese magnoliavine: warm in nature, taste is sour, sweet, returns lung, the heart, kidney channel, has convergence astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, effect of kidney calming, breathe heavily for void of coughing for a long time, emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and feeble pulse of losing heart, interior heat is quenched one's thirst, the cards such as palpitation and insomnia.
Fructus Hordei Germinatus: taste is sweet, property is put down, and return spleen, stomach warp, have promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, move back effect of newborn dissipate-swelling, do not disappear for dyspepsia, abdominal distention, insufficiency of the spleen food is few, and newborn sweat smoulders, swollen breasts, and women weans, and the logical breast of Fructus Hordei Germinatus strengthening the spleen and stomach waits card.
Purslane: latin name
portulacae herba, taste acid, cold in nature, return large intestine, Liver Channel, have clearing heat and detoxicating, Li Shui dries, and loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, the effect of the cool blood that stops blooding, cures mainly dysentery, enteritis, ephritis, and postpartum, uterine hemorrhage, had blood in stool, the cards such as mastitis.
Wilsonii: be the root of studies on plants of Acanthopanax Miq. in Araliaceae wilsonii, rhizome or cauline leaf: latin name
acanthopanacis Senticosi Radix et Rhizoma seu Caulis, taste is pungent, bitter, micro-sweet, warm in nature, enter spleen, kidney, the heart channel of Hang-Shaoyin, have and replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain, the effect of dispelling rheumatism, soft for wind-cold-dampness arthralgia, lumbocrural pain, muscles and bones impotence, be slow in action, the card such as body void is thin and weak, traumatic injury, fracture, oedema, beriberi, uncontrolled urination are itched.
The stem of noble dendrobium: latin name
dendrobii Caulis, cold nature, taste is sweet, returns stomach, kidney channel, has reinforcing stomach reg fluid, and nourishing Yin and clearing heat effect cures mainly the moon and hinders body fluid deficiency, dry polydipsia, and food is few retches, abnormal heat after being ill, and order is secretly not clear waits card.
Felwort: bitter, cold in nature, enters liver, gallbladder channel, has heat-clearing and damp-drying drug, falls the effect of letting out irascibility and cholagogic, and the chest side of body being mainly used in dampness-heat of liver channel caused is had a pain, and bitter taste is deaf, red eye, swell pain; Jaundice with damp-heat pathogen; The dizzy order of liver-fire flaming swells; The high heat of irascibility wind transmission is through taking out; The card such as leukorrhea, difficult urination of damp invasion of lower energizer.
The red sage root: bitter, cold nature, enters the heart, Liver Channel, has promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, and cool blood disappears carbuncle, and clear away heart-fire relieving restlessness, the effect of nourishing blood and tranquilization, and for irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, hot numbness pain, and sore swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the cards such as angina pectoris.
Oldenlandia diffusa: bitter, sweet, cold in nature, enters the heart, liver, spleen, large intestine channel, has clearing heat and detoxicating, the effect of clearing damp and promoting diuresis, for dyspnea and cough due to lung-heat, abscess of throat, acute appendicitis, furuncle sore, venomous snake bite, heat drenches puckery pain, oedema, dysentery, enteritis, jaundice with damp-heat pathogen, the cards such as cancerous swelling.
Subprostrate sophora: bitter, cold in nature, enter the heart, lung, large intestine channel, there is removing toxic substances relieve sore throat, clearing heat and promoting diuresis, effect that desinsection is anticancer, the cards such as abscess of throat, gum swells dentalgia, cough with lung heat, dysentery, jaundice, the swollen favus of the scalp of heat.
The radix paeoniae rubrathe: bitter, micro-hardship, enter Liver Channel, have purge the green, clearing heat and cooling blood, the effect of stasis-dispelling and pain-killing is mainly used in the red eye, swell pain of high liver fire, has a dizzy spell, pain in chest and hypochondrium, and the hot tongue of body of warm heat disease heat invading xuefen is deep red, and macula is hemorrhage, and blood stasis is through closing; The haematemesis hematuria of the absurd row of burning hot flourishing urgent blood; The trip of women's blood-head is through too much; Various pain caused by blood retardance; The sore furuncle carbuncle of blood-head poison Sheng is swollen waits card.
Ardisia japonica: property is put down, pungent, the micro-hardship of taste.Return lung, Liver Channel, there is preventing phlegm from forming and stopping coughing, dampness removing, the effect of invigorating blood circulation, cure mainly the cards such as cough, blood-stained sputum, chronic bronchitis, jaundice with damp-heat pathogen, injury from falling down.
Schizonepeta: taste is pungent, slightly warm in nature, enters lung, Liver Channel, has and expel pathogenic wind from the body surface, and declares malicious promoting eruption, and regulating blood condition stops effect of convulsion, cures mainly flu fever and chills, headache, eye itching, pharyngalgia, cough, measles, rubella, carbuncle sore, brigadier, spit blood, clot blood, has blood in stool, uterine bleeding, the card such as affection by cold after delivery, bruise.
Sweet wormwood: latin name
artemisiae Annuae Herba, bitter, pungent, cold in nature, return liver, gallbladder channel, have abnormal heat clearly thoroughly, cool blood is except steaming, and except steaming, effect of preventing malaria, cures mainly summer-heat evil heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to yin labor heat, malaria fever and chills, the cards such as jaundice with damp-heat pathogen.
Garden burnet: bitter, acid, puckery, cold nature, enter large intestine, liver, stomach warp, have cooling blood and hemostasis, the effect of removing toxic substances sore, for caused by blood-head various go out blood trouble, especially be applicable to part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels heat contain, compel the bottom such as the having blood in stool of the absurd row of blood, bloody flux, metrorrhagia and go out blood trouble, garden burnet has good anastalsis, has stronger inhibitory action to staphylococcus aureus, beta hemolytic streptococcus, pneumococcus etc.
Chinese holly: latin name
ilicis Chinensis Folium, bitter, cold in nature, return lung, large intestine, urinary bladder channel, have clearing heat and detoxicating, effect of promoting blood circulation and hemostasis, for chronic bronchitis, pyelonephritis, bacillary dysentery; Burn and scald is controlled in external application, the ulcer of lower limb, leprelcosis, and extra earning is hemorrhage, frostbite, mastitis, the cards such as chapped skin.
Eclipta: taste is sweet, sour, cold in nature, returns liver, kidney channel, plays and tonify the liver and kidney, the effect of cooling blood and hemostasis, for having a dizzy spell caused by the deficiency of liver-yin and kidney-yin, blurring of vision, and soreness and weakness of waist and knees; Be suitable for the deficiency of Yin and have hot person, be used for the treatment of the haematemesis of accumulated heat in stomach, the cards such as the hemoptysis of heat impairing pulmonary collateral.
Radix Liriopes: latin name
liriopes radix, sweet, the micro-hardship of taste, cold nature, the thoughts of returning home, lung, stomach warp, have nourishing Yin and promoting production of body fluid, effect that moistening lung clears away heart-fire, and for dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, vexed insomnia, the cards such as the dry constipation of intestines.
Gorgon fruit: taste is sweet, puckery, property is put down.Return spleen, kidney channel.There is supplementing the kidney to control the nocturnal, tonifying spleen antidiarrheal, the function that clearing damp is only with, cure mainly emission, splenasthenic diarrhea, insufficiency of the spleen gonorrhoea, be with inferior card.
Dwarf sheareria herb: bitter, property is put down, and have clearing heat and detoxicating, inducing diuresis for removing edema, effect of dispelling wind, cures mainly oedema, nameless sores or boils, the card such as grade of headache due to pathogenic wind-heat.
Rust-coloured crotalaria herb with root: for the false ground of pulse family Crotalaria plant is blue or the root of bar leaf crotalaria mucronata or herb, bitter, micro-acid, property is put down, and returns lung, liver, kidney channel, have nourishing liver and kidney, cough-relieving is breathed heavily, and effect of dampness removing, cures mainly tinnitus, deafness, has a dizzy spell, seminal emission, menorrhalgia, leukorrhea, chronic cough phlegm blood, asthma, ephritis, difficult urination, tonsillitis, mumps, the cards such as furuncle swelling toxin.
Japanese white birch bark: be the bark of Betulaceae Betula plant white birch, bitter, property is put down, and returns lung, stomach, large intestine channel, has clearing heat and promoting diuresis, expelling phlegm and arresting coughing, effect of removing toxic substances, cures mainly abscess of throat, cough and asthma, jaundice, diarrhoea, dysentery, stranguria, difficult urination, acute mastitis, sore, pruigo, the cards such as scald.
Present invention also offers a kind of feed being used for the treatment of piglet diarrhea, its raw material comprises corn, dregs of beans, fish meal, calcium monohydrogen phosphate, salt, the Chinese herbal feed additive being used for the treatment of piglet diarrhea, vitamin premix, serine, glutamic acid, glycine, copper sulphate and zinc sulfate.
In described feed, the weight portion of each raw material is respectively corn 65 weight portion ~ 70 weight portion, dregs of beans 25 weight portion ~ 30 weight portion, fish meal 8 weight portion ~ 12 weight portion, calcium monohydrogen phosphate 2 weight portion ~ 4 weight portion, salt 1 weight portion ~ 3 weight portion, be used for the treatment of Chinese herbal feed additive 0.5 weight portion ~ 1.5 weight portion of piglet diarrhea, vitamin premix 0.2 weight portion ~ 0.4 weight portion, serine 0.05 weight portion ~ 0.15 weight portion, glutamic acid 0.05 weight portion ~ 0.15 weight portion, glycine 0.05 weight portion ~ 0.15 weight portion, copper sulphate 0.05 weight portion ~ 0.15 weight portion and zinc sulfate 0.05 weight portion ~ 0.15 weight portion.
Further preferably, in described feed, the weight portion of each raw material is respectively corn 68 weight portion, dregs of beans 28 weight portion, fish meal 10 weight portion, calcium monohydrogen phosphate 3 weight portion, salt 2 weight portion, Chinese herbal feed additive 1 weight portion being used for the treatment of piglet diarrhea, vitamin premix 0.3 weight portion, serine 0.1 weight portion, glutamic acid 0.1 weight portion, glycine 0.1 weight portion, copper sulphate 0.1 weight portion and zinc sulfate 0.1 weight portion.
Described vitamin premix is, every kg contains vitamin A 4,500 ten thousand IU, vitamin D
31600 ten thousand IU, vitamin e1 00000mg, vitamin K
310000mg, vitamin V B
18000mg, Cobastab
230000mg, Cobastab
12120mg, Cobastab
61100mg, biotin 500mg, calcium pantothenate 80000mg, folic acid 6000mg, niacinamide 150000mg are the diligent multidimensional-101 (Weifang Heng Mao animal health-care product Co., Ltd provides) of henry.
Present invention also offers the preparation method of above-mentioned feed, be specially and each interpolation raw material in feed is pulverized, mixing and stirring, obtain feed.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 drug decocting liquid 1
By Swertia patens 30g, wolf's milk 20g, nutmeg 30g, tarragon 20g, fruit of Chinese magnoliavine 40g, Fructus Hordei Germinatus 20g, purslane 30g, wilsonii 40g, stem of noble dendrobium 25g, felwort 20g, red sage root 25g, oldenlandia diffusa 25g, subprostrate sophora 30g, radix paeoniae rubrathe 30g, ardisia japonica 25g, schizonepeta 20g, sweet wormwood 20g, garden burnet 25g, Chinese holly 30g, eclipta 35g, Radix Liriopes 30g, Gorgon fruit 30g, dwarf sheareria herb 20g, rust-coloured crotalaria herb with root 20g and japanese white birch bark 20g mixes, obtain mixture, add the water of 2kg, carry out decoction process 2 hours, decoction liquor is filtered, obtain the first filtrate, filter residue adds the water of 1.2kg again, carry out decoction process 2 hours, decoction liquor is filtered again, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, be condensed into the decoction liquor 1 of 0.5g/ml.
Embodiment 2 drug decocting liquid 2
By Swertia patens 28g, wolf's milk 18g, nutmeg 28g, tarragon 18g, fruit of Chinese magnoliavine 38g, Fructus Hordei Germinatus 18g, purslane 28g, wilsonii 38g, stem of noble dendrobium 23g, felwort 18g, red sage root 23g, oldenlandia diffusa 23g, subprostrate sophora 28g, radix paeoniae rubrathe 28g, ardisia japonica 23g, schizonepeta 18g, sweet wormwood 18g, garden burnet 23g, Chinese holly 28g, eclipta 33g, Radix Liriopes 28g, Gorgon fruit 28g, dwarf sheareria herb 18g, rust-coloured crotalaria herb with root 18g and japanese white birch bark 18g mixes, obtain mixture, add the water of 2kg, carry out decoction process 2 hours, decoction liquor is filtered, obtain the first filtrate, filter residue adds the water of 1.2kg again, carry out decoction process 2 hours, decoction liquor is filtered again, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, be condensed into the decoction liquor 2 of 0.5g/ml.
Embodiment 3 drug decocting liquid 3
By Swertia patens 32g, wolf's milk 22g, nutmeg 32g, tarragon 22g, fruit of Chinese magnoliavine 42g, Fructus Hordei Germinatus 22g, purslane 32g, wilsonii 42g, stem of noble dendrobium 27g, felwort 22g, red sage root 27g, oldenlandia diffusa 27g, subprostrate sophora 32g, radix paeoniae rubrathe 32g, ardisia japonica 27g, schizonepeta 22g, sweet wormwood 22g, garden burnet 27g, Chinese holly 32g, eclipta 37g, Radix Liriopes 32g, Gorgon fruit 32g, dwarf sheareria herb 22g, rust-coloured crotalaria herb with root 22g and japanese white birch bark 22g mixes, obtain mixture, add the water of 2kg, carry out decoction process 2 hours, decoction liquor is filtered, obtain the first filtrate, filter residue adds the water of 1.2kg again, carry out decoction process 2 hours, decoction liquor is filtered again, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, be condensed into the decoction liquor 3 of 0.5g/ml.
Embodiment 4 feed addictive 1
By wolf's milk 20g, nutmeg 30g, tarragon 20g, fruit of Chinese magnoliavine 40g, purslane 30g, wilsonii 40g, stem of noble dendrobium 25g, oldenlandia diffusa 25g, radix paeoniae rubrathe 30g, ardisia japonica 25g, sweet wormwood 20g, garden burnet 25g, eclipta 35g, Radix Liriopes 30g, Gorgon fruit 30g, dwarf sheareria herb 20g, rust-coloured crotalaria herb with root 20g mixes, obtain mixture, add determining alcohol be 60% ethanolic solution carry out heating and refluxing extraction 2 times, each refluxing extraction 3h, the amount of the mixture interpolation ethanolic solution of every 1kg is 4L, the extract obtained merges filtration, leaves standstill 24h, and recovery ethanol is also concentrated, be condensed into thick paste, dry, pulverize into the first powder, by Swertia patens 30g, Fructus Hordei Germinatus 20g, felwort 20g, red sage root 25g, subprostrate sophora 30g, schizonepeta 20g, Chinese holly 30g and japanese white birch bark 20g mixes, and obtains mixture, adds the water of 500g, carry out decoction process 2 hours, decoction liquor is filtered, obtain the first filtrate, filter residue adds the water of 350g again, carries out decoction process 2 hours, decoction liquor is again filtered, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, reduced pressure concentration removes into thick paste, dry, be ground into the second powder, by the first powder and the mixing of the second powder, obtain feed addictive 1.
Embodiment 5 feed addictive 2
By wolf's milk 18g, nutmeg 28g, tarragon 18g, fruit of Chinese magnoliavine 38g, purslane 28g, wilsonii 38g, stem of noble dendrobium 23g, oldenlandia diffusa 23g, radix paeoniae rubrathe 28g, ardisia japonica 23g, sweet wormwood 18g, garden burnet 23g, eclipta 33g, Radix Liriopes 28g, Gorgon fruit 28g, dwarf sheareria herb 18g, rust-coloured crotalaria herb with root 18g mixes, obtain mixture, add determining alcohol be 60% ethanolic solution carry out heating and refluxing extraction 2 times, each refluxing extraction 3h, the amount of the mixture interpolation ethanolic solution of every 1kg is 4L, the extract obtained merges filtration, leaves standstill 24h, and recovery ethanol is also concentrated, be condensed into thick paste, dry, pulverize into the first powder, by Swertia patens 28g, Fructus Hordei Germinatus 18g, felwort 18g, red sage root 23g, subprostrate sophora 28g, schizonepeta 18g, Chinese holly 28g and japanese white birch bark 18g mixes, and obtains mixture, adds the water of 500g, carry out decoction process 2 hours, decoction liquor is filtered, obtain the first filtrate, filter residue adds the water of 350g again, carries out decoction process 2 hours, decoction liquor is again filtered, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, reduced pressure concentration removes into thick paste, dry, be ground into the second powder, by the first powder and the mixing of the second powder, obtain feed addictive 2.
Embodiment 6 feed addictive 3
By wolf's milk 22g, nutmeg 32g, tarragon 22g, fruit of Chinese magnoliavine 42g, purslane 32g, wilsonii 42g, stem of noble dendrobium 27g, oldenlandia diffusa 27g, radix paeoniae rubrathe 32g, ardisia japonica 27g, sweet wormwood 22g, garden burnet 27g, eclipta 37g, Radix Liriopes 32g, Gorgon fruit 32g, dwarf sheareria herb 22g, rust-coloured crotalaria herb with root 22g mixes, obtain mixture, add determining alcohol be 60% ethanolic solution carry out heating and refluxing extraction 2 times, each refluxing extraction 3h, the amount of the mixture interpolation ethanolic solution of every 1kg is 4L, the extract obtained merges filtration, leaves standstill 24h, and recovery ethanol is also concentrated, be condensed into thick paste, dry, pulverize into the first powder, by Swertia patens 32g, Fructus Hordei Germinatus 22g, felwort 22g, red sage root 27g, subprostrate sophora 32g, schizonepeta 22g, Chinese holly 32g and japanese white birch bark 22g mixes, and obtains mixture, adds the water of 500g, carry out decoction process 2 hours, decoction liquor is filtered, obtain the first filtrate, filter residue adds the water of 350g again, carries out decoction process 2 hours, decoction liquor is again filtered, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, reduced pressure concentration removes into thick paste, dry, be ground into the second powder, by the first powder and the mixing of the second powder, obtain feed addictive 3.
Embodiment 7 toxicological experiment
Acute toxicity test
Because cannot LD be measured
50, therefore carried out the mensuration of maximum dosage-feeding.The medicated feed additive 1 embodiment 4 prepared is dissolved in distilled water, mouse is divided into two groups, the feed addictive 1 gavage mouse that prepared by the decoction liquor 1 embodiment 1 prepared and embodiment 4 be dissolved in distilled water, result shows, with the maximum administration concentration 19.23g crude drug/ml of medicine, maximum administration volume 40ml/kg was administered twice to mouse stomach in 24 hours, and bad reaction and death do not appear in animal.The each internal organs no abnormality seen of anatomic observation.
Long term toxicity test
This test application SD rat 80, rat is divided into two groups, the decoction liquor 1 of gavage embodiment 1 preparation and the medicated feed additive 1 of embodiment 4 preparation respectively, the medicated feed additive 1 embodiment 4 prepared is dissolved in distilled water, be configured to solution gavage, if control group and 16g, 32g, 64g crude drug/kg dosage group, continuous gastric infusion 4 weeks, observes the impact of Chinese medicine composition of the present invention on animal indices.Result of the test shows, successive administration 4 weeks, and the body weight, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index etc. of Chinese medicine composition of the present invention to rat all have no significant effect; Blood biochemical ten binomial index determining result, administration 4 weeks low dose group BiLi values, may with wherein three serum sample haemolysis be relevant higher than control group (P < 0.05); Low dose group, middle dosage group TP value are higher than control group (P < 0.05), but all within normal physiologic range, other index compares no significant difference with control group.Convalescence each administration group indices measured value no significant difference more equal to control group.Each group of each internal organs gross examination of skeletal muscle no abnormality seen.
In sum, the acute toxicity test in mice of this medicine has no toxic reaction, and rat chronic toxicity test also has no overt toxicity reaction.
Embodiment 8 feed 1
By Chinese herbal feed additive 1 prepared by corn 68kg, dregs of beans 28kg, fish meal 10kg, calcium monohydrogen phosphate 3kg, salt 2kg, 1kg embodiment 4, prosperous diligent multidimensional-101 (Weifang Heng Mao animal health-care product Co., Ltd provides) 0.3kg of vitamin premix, serine 0.1 kg, glutamic acid 0.1 kg, glycine 0.1 kg, copper sulphate 0.1 kg and zinc sulfate 0.1 kg pulverize respectively, mixing and stirring, obtains feed 1.
Comparative example 1 feed 2
Corn 68kg, dregs of beans 28kg, fish meal 10kg, calcium monohydrogen phosphate 3kg, salt 2kg, prosperous diligent multidimensional-101 (Weifang Heng Mao animal health-care product Co., Ltd provides) 0.3kg of vitamin premix, serine 0.1 kg, glutamic acid 0.1 kg, glycine 0.1 kg, copper sulphate 0.1 kg and zinc sulfate 0.1 kg are pulverized respectively, mixing and stirring, obtains feed 2.
Embodiment 9 treats data
Case is originated
Certain two pig farm that case derives from piglet Huang, dysentery characterized by white mucous stool is in a bad way, the suckling pig on one of them pig farm (the first pig farm) was when birth about two weeks, broodly nearly all there is diarrhea, the yellowish-brown loose stool that initial discharge is more smelly, after 1 ~ 2d, namely white, stench loose stool is drained, suspected of dysentery characterized by white mucous stool; Another one pig farm (the second pig farm) then occurs that the symptom of acutely dropping nearly all occurs in one day brood piglet after birth, suspected of yellow dysentery.
For reagent thing
Control group 1: every piglet intramuscular injection terramycin 0.1 mg/kg, 1 time/d, the feed 2 of feeding comparative example 1 preparation simultaneously, the feed 2 of test group 1: every feeding comparative example 1 preparation, the decoction liquor 1 that every day is prepared by gavage embodiment 1, every day 200ml, test group 2: every feeding embodiment 8 preparation feed 1, every day, the Chinese medicine crude drug amount of feeding was 100g.
Experimental animal
In two pig farms of morbidity, select kind identical, the morbidity piglet that the sow that parity, Time to pregnancy, body condition are close produces is as experimental animal.
Making a definite diagnosis of case
Respectively in two pig farms, random inspection 60 parts of anal swabs from morbidity piglet, at 37 DEG C, cultivate 24h with maconkey agar culture medium, the colonies typical that two have Escherichia coli feature got by every part of pathological material of disease, and adopts fibrial antigen identification method to identify.Result shows: the first pig farm, and enteropathogenic E. Coli infection rate is 98 %, by clinicing symptom observation, is diagnosed as the white scour of piglet.Second pig farm, enteropathogenic E. Coli infection rate is 100 %, by clinicing symptom observation, is diagnosed as piglet yellow scour.
Grouping and process
According to the actual conditions on the first pig farm, according to being convenient to management, mutually isolated principle divides into groups.Choose the morbidity piglet 271 of test, be divided into 3 groups: control group 90, every piglet intramuscular injection terramycin 0.1 mg/kg, 1 time/d, the feed 2 of feeding comparative example 1 preparation simultaneously; Test group 1 totally 90, feed 2 prepared by every feeding comparative example 1, the decoction liquor 1 that every day is prepared by gavage embodiment 1, every day 200ml, test group 2 totally 91, feed 1 prepared by every feeding embodiment 8, every day, the Chinese medicine crude drug amount of feeding was 100g.
According to the actual conditions on the second pig farm, according to being convenient to management, mutually isolated principle divides into groups.Choose the morbidity piglet 297 of test, be divided into 3 groups: control group 97, every piglet intramuscular injection terramycin 0.1 mg/kg, 1 time/d, the feed 2 of feeding comparative example 1 preparation simultaneously; Test group 1 totally 100, feed 2 prepared by every feeding comparative example 1, the decoction liquor 1 that every day is prepared by gavage embodiment 1, every day 200ml, test group 2 totally 100, feed 1 prepared by every feeding embodiment 8, every day, the Chinese medicine crude drug amount of feeding was 100g.
Criterion
After treatment 3d, the state of mind, appetite situation etc. of observed and recorded piglet.Diarrhea stops, and appetite, ight soil proterties recover normal for curing, and diarrhea number of times is reduced to improvement, otherwise is invalid.
Data processing
Data SPASS software carries out statistical analysis, using P < 0.05 as significant difference criterion.
Result of the test
The result for the treatment of of the white scour of piglet, in table 1.
The result for the treatment of of table 1 white scour of piglet
| Group | Treatment head number | Cure number | Good revolution | Invalid number | Efficient (%) |
| Test group 1 | 90 | 81 | 6 | 3 | 96.7 |
| Test group 2 | 91 | 83 | 6 | 2 | 97.8 |
| Control group | 90 | 64 | 15 | 11 | 87.8 |
As can be seen from Table 1, the decoction liquor adopting medicine provided by the invention to prepare and medicated feed additive are evident in efficacy in the treatment white scour of piglet, P<0.05.
The result for the treatment of of piglet yellow scour, in table 2.
The result for the treatment of of table 1 white scour of piglet
| Group | Treatment head number | Cure number | Good revolution | Invalid number | Efficient (%) |
| Test group 1 | 100 | 87 | 11 | 2 | 98.0 |
| Test group 2 | 100 | 82 | 14 | 4 | 96.0 |
| Control group | 97 | 67 | 17 | 13 | 86.6 |
As can be seen from Table 2, the decoction liquor adopting medicine provided by the invention to prepare and medicated feed additive are evident in efficacy in treatment piglet yellow scour, P<0.05.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. be used for the treatment of a feed for piglet diarrhea, it is characterized in that: raw material comprises corn, dregs of beans, fish meal, calcium monohydrogen phosphate, salt, the Chinese herbal feed additive being used for the treatment of piglet diarrhea, vitamin premix, serine, glutamic acid, glycine, copper sulphate and zinc sulfate.
2. feed as claimed in claim 1, it is characterized in that: the weight portion of each raw material is respectively corn 65 weight portion ~ 70 weight portion, dregs of beans 25 weight portion ~ 30 weight portion, fish meal 8 weight portion ~ 12 weight portion, calcium monohydrogen phosphate 2 weight portion ~ 4 weight portion, salt 1 weight portion ~ 3 weight portion, be used for the treatment of Chinese herbal feed additive 0.5 weight portion ~ 1.5 weight portion of piglet diarrhea, vitamin premix 0.2 weight portion ~ 0.4 weight portion, serine 0.05 weight portion ~ 0.15 weight portion, glutamic acid 0.05 weight portion ~ 0.15 weight portion, glycine 0.05 weight portion ~ 0.15 weight portion, copper sulphate 0.05 weight portion ~ 0.15 weight portion and zinc sulfate 0.05 weight portion ~ 0.15 weight portion.
3. feed as claimed in claim 1 or 2, is characterized in that: the weight portion of each raw material is respectively corn 68 weight portion, dregs of beans 28 weight portion, fish meal 10 weight portion, calcium monohydrogen phosphate 3 weight portion, salt 2 weight portion, Chinese herbal feed additive 1 weight portion being used for the treatment of piglet diarrhea, vitamin premix 0.3 weight portion, serine 0.1 weight portion, glutamic acid 0.1 weight portion, glycine 0.1 weight portion, copper sulphate 0.1 weight portion and zinc sulfate 0.1 weight portion.
4. the feed as described in claims 1 to 3, is characterized in that: the bulk drug of described medicated feed additive comprises Swertia patens, wolf's milk, nutmeg, tarragon, the fruit of Chinese magnoliavine, Fructus Hordei Germinatus, purslane, wilsonii, the stem of noble dendrobium, felwort, the red sage root, oldenlandia diffusa, subprostrate sophora, the radix paeoniae rubrathe, ardisia japonica, schizonepeta, sweet wormwood, garden burnet, Chinese holly, eclipta, Radix Liriopes, Gorgon fruit, dwarf sheareria herb, rust-coloured crotalaria herb with root and japanese white birch bark.
5. the feed as described in Claims 1-4, is characterized in that: in described medicated feed additive, the weight of each bulk drug is respectively Swertia patens 25 weight portion ~ 35 weight portion, wolf's milk 15 weight portion ~ 25 weight portion, nutmeg 25 weight portion ~ 35 weight portion, tarragon 15 weight portion ~ 25 weight portion, the fruit of Chinese magnoliavine 35 weight portion ~ 45 weight portion, Fructus Hordei Germinatus 15 weight portion ~ 25 weight portion, purslane 25 weight portion ~ 35 weight portion, wilsonii 35 weight portion ~ 45 weight portion, the stem of noble dendrobium 20 weight portion ~ 30 weight portion, felwort 15 weight portion ~ 25 weight portion, the red sage root 20 weight portion ~ 30 weight portion, oldenlandia diffusa 20 weight portion ~ 30 weight portion, subprostrate sophora 25 weight portion ~ 35 weight portion, the radix paeoniae rubrathe 25 weight portion ~ 35 weight portion, ardisia japonica 20 weight portion ~ 30 weight portion, schizonepeta 15 weight portion ~ 25 weight portion, sweet wormwood 15 weight portion ~ 25 weight portion, garden burnet 20 weight portion ~ 30 weight portion, Chinese holly 25 weight portion ~ 35 weight portion, eclipta 30 weight portion ~ 40 weight portion, Radix Liriopes 25 weight portion ~ 35 weight portion, Gorgon fruit 25 weight portion ~ 35 weight portion, dwarf sheareria herb 15 weight portion ~ 25 weight portion, rust-coloured crotalaria herb with root 15 weight portion ~ 25 weight portion and japanese white birch bark 15 weight portion ~ 25 weight portion.
6. the feed as described in claim 1 to 5, is characterized in that: in described medicine, the weight of each bulk drug is respectively Swertia patens 28 weight portion ~ 32 weight portion, wolf's milk 18 weight portion ~ 22 weight portion, nutmeg 28 weight portion ~ 32 weight portion, tarragon 18 weight portion ~ 22 weight portion, the fruit of Chinese magnoliavine 38 weight portion ~ 42 weight portion, Fructus Hordei Germinatus 18 weight portion ~ 22 weight portion, purslane 28 weight portion ~ 32 weight portion, wilsonii 38 weight portion ~ 42 weight portion, the stem of noble dendrobium 23 weight portion ~ 27 weight portion, felwort 18 weight portion ~ 22 weight portion, the red sage root 23 weight portion ~ 27 weight portion, oldenlandia diffusa 23 weight portion ~ 27 weight portion, subprostrate sophora 28 weight portion ~ 32 weight portion, the radix paeoniae rubrathe 28 weight portion ~ 32 weight portion, ardisia japonica 23 weight portion ~ 27 weight portion, schizonepeta 18 weight portion ~ 22 weight portion, sweet wormwood 18 weight portion ~ 22 weight portion, garden burnet 23 weight portion ~ 27 weight portion, Chinese holly 28 weight portion ~ 32 weight portion, eclipta 33 weight portion ~ 37 weight portion, Radix Liriopes 28 weight portion ~ 32 weight portion, Gorgon fruit 28 weight portion ~ 32 weight portion, dwarf sheareria herb 18 weight portion ~ 22 weight portion, rust-coloured crotalaria herb with root 18 weight portion ~ 22 weight portion and japanese white birch bark 18 weight portion ~ 22 weight portion.
7. the preparation method of feed described in claim 1 to 6, is characterized in that, comprising:
The first step, by wolf's milk, nutmeg, tarragon, the fruit of Chinese magnoliavine, purslane, wilsonii, the stem of noble dendrobium, oldenlandia diffusa, the radix paeoniae rubrathe, ardisia japonica, sweet wormwood, garden burnet, eclipta, Radix Liriopes, Gorgon fruit, dwarf sheareria herb and the mixing of rust-coloured crotalaria herb with root parts by weights, obtain mixture, add determining alcohol be 50% ~ 70% ethanolic solution carry out heating and refluxing extraction 2 times, each refluxing extraction 2h ~ 3h, the amount of the mixture interpolation ethanolic solution of every 1kg is 3L ~ 5L, the extract obtained merges filtration, leave standstill 24h, reclaim ethanol and concentrate, be condensed into thick paste, dry, be ground into the first powder, remaining components parts by weights is mixed, obtains mixture, add the water relative to mixture quality 2 ~ 4 times, carry out decoction process 1 ~ 3 hour, decoction liquor is filtered, obtain the first filtrate, filter residue adds the water relative to original mixture quality 1 ~ 3 times again, carry out decoction process 1 ~ 3 hour, decoction liquor is filtered again, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, reduced pressure concentration removes into thick paste, dry, pulverize into the second powder, by the first powder and the mixing of the second powder, obtain feed addictive,
Second step, pulverizes each interpolation raw material in feed, mixing and stirring, obtains feed.
8. be used for the treatment of a medicated feed additive for piglet diarrhea, it is characterized in that: bulk drug comprises Swertia patens, wolf's milk, nutmeg, tarragon, the fruit of Chinese magnoliavine, Fructus Hordei Germinatus, purslane, wilsonii, the stem of noble dendrobium, felwort, the red sage root, oldenlandia diffusa, subprostrate sophora, the radix paeoniae rubrathe, ardisia japonica, schizonepeta, sweet wormwood, garden burnet, Chinese holly, eclipta, Radix Liriopes, Gorgon fruit, dwarf sheareria herb, rust-coloured crotalaria herb with root and japanese white birch bark.
9. medicated feed additive as claimed in claim 8, is characterized in that: the weight of each bulk drug is respectively Swertia patens 25 weight portion ~ 35 weight portion, wolf's milk 15 weight portion ~ 25 weight portion, nutmeg 25 weight portion ~ 35 weight portion, tarragon 15 weight portion ~ 25 weight portion, the fruit of Chinese magnoliavine 35 weight portion ~ 45 weight portion, Fructus Hordei Germinatus 15 weight portion ~ 25 weight portion, purslane 25 weight portion ~ 35 weight portion, wilsonii 35 weight portion ~ 45 weight portion, the stem of noble dendrobium 20 weight portion ~ 30 weight portion, felwort 15 weight portion ~ 25 weight portion, the red sage root 20 weight portion ~ 30 weight portion, oldenlandia diffusa 20 weight portion ~ 30 weight portion, subprostrate sophora 25 weight portion ~ 35 weight portion, the radix paeoniae rubrathe 25 weight portion ~ 35 weight portion, ardisia japonica 20 weight portion ~ 30 weight portion, schizonepeta 15 weight portion ~ 25 weight portion, sweet wormwood 15 weight portion ~ 25 weight portion, garden burnet 20 weight portion ~ 30 weight portion, Chinese holly 25 weight portion ~ 35 weight portion, eclipta 30 weight portion ~ 40 weight portion, Radix Liriopes 25 weight portion ~ 35 weight portion, Gorgon fruit 25 weight portion ~ 35 weight portion, dwarf sheareria herb 15 weight portion ~ 25 weight portion, rust-coloured crotalaria herb with root 15 weight portion ~ 25 weight portion and japanese white birch bark 15 weight portion ~ 25 weight portion.
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| CN105213483A (en) * | 2015-09-26 | 2016-01-06 | 梁佳灵 | The Chinese medicine preparation of control artificial breeding wild boar dysentery |
| CN105661066A (en) * | 2016-01-15 | 2016-06-15 | 广州暨南生物医药研究开发基地有限公司 | Feed additive capable of stimulating appetite of pigs and preparation method of feed additive |
| CN105767551A (en) * | 2016-03-24 | 2016-07-20 | 湖南农业大学 | Piglet intestinal physiology regulating feed additive and use method thereof |
| CN106721330A (en) * | 2017-03-28 | 2017-05-31 | 滁州朝昱农业科技有限公司 | A kind of pig feed additive and preparation method for piglet stop dysentery |
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| CN104872448A (en) * | 2015-06-11 | 2015-09-02 | 山东新希望六和集团有限公司 | Compound feed for 2-3-month-old piglets and preparing method thereof |
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| CN107095058A (en) * | 2017-05-17 | 2017-08-29 | 佛山市高明区生产力促进中心 | A kind of high-efficiency feed for being used to treat live pig escherichia coli dysentery |
| CN111264694A (en) * | 2018-12-05 | 2020-06-12 | 北京康为天生物科技有限公司 | Antibiotic eliminating agent and preparation method and application thereof |
| CN110771746A (en) * | 2019-10-28 | 2020-02-11 | 高安华达牧业有限公司 | Animal feed additive and feed containing same |
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