CN103947893A - Feed and traditional Chinese medicine composition for preventing and treating duck aspergillosis and preparation method of feed - Google Patents
Feed and traditional Chinese medicine composition for preventing and treating duck aspergillosis and preparation method of feed Download PDFInfo
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Abstract
The invention discloses a feed and a traditional Chinese medicine composition for preventing and treating duck aspergillosis and a preparation method of the feed. The feed comprises a basic feed, microelement additives, vitamin additives and traditional Chinese medicine additives, wherein the traditional Chinese medicine additives comprise fritillaria cirrhosa, bamboo juice, tabasheer, platycodon grandiflorum, fructus perillae, aristolochia debilis sieb, lepidium apetalum willd, herba ardisiae japonicae, flos daturae, scutellaria baicalensis, coptis chinensis, radix sophorae flavescentis, barberry roots, horsetail, white mulberry root-barks, indigo naturalis, large-leaved gentian, dried orange peels, fructus citri, folium rhododendri daurici, thorny elaeagnus leaves, codonopsis pilosula, yams, fructus psoraleae, white perilla leaves and artemisia capillaries. The feed contains the traditional Chinese medicine additives and has the beneficial effects that the course of treatment of the duck aspergillosis is short, the drug residue content is low, the toxicity is reduced, the healing rate is high, the pollution is avoided, the effects of removing dampness to resolve sputum, relieving asthma, regulating vital energy and improving immunity are achieved, the duck aspergillosis does not easily relapse after being healed, and the cost and the price are low.
Description
Technical field
The present invention relates to technical field of animal, particularly a kind of for preventing and treating feed, Chinese medicine composition and the preparation method of duck aspergillosis.
Background technology
Aspergillosis is a kind of common mycosis that multiple bird all can infect.In duck with the susceptible of duckling.Sick feature is respiratory tract generation Aspergillus pneumonia.Cause of disease is mainly aspergillus fumigatus, and in addition, aspergillus niger, aspergillus flavus etc. also has pathogenicity in various degree.The spore resistance of Aspergillus is very strong, boil and just can kill for latter 5 minutes, as must be through the deactivation of 1～3 hour ability in thimerosal.Pneumonia refers to the inflammation of last air flue, alveolar and interstitial lung eventually.Can be by pathogenic microorganisms such as bacterium, virus, fungi, parasites, and the chemical factors such as radioactive ray, imbedibility foreign matter causes.
Various birds all can infect, but comparatively common with duckling, and morbidity mostly is mass-sending property and acute process, go out after shell the susceptible of the duckling in 2 days, and during 5～7 age in days, the incidence of disease peaks, and the death rate can reach more than 50%.The duck infection morbidity of growing up is generally and distributes, and is chronic process, and the death rate is lower.
The how sleeping volt of acute case, food refusal, reacts indifferent to external world.The course of disease is slightly long, and expiratory dyspnea, stretches neck and dehisce to breathe as seen; Nasal cavity flows out more mucus; Some eyelids are bonding, and eyes are blind, and some eyelid drums are protruding, include cheesy thing; Often draw light green loose stool, the later stage is in palsy and death.Cuing open the visible lung of inspection has grain grain to the large yellow-white of mung bean or canescence tubercle, and cutting the visible center of tubercle is the caseous necrosis tissue of homogeneous, includes a large amount of mycelium; Air bag has canescence or light green mildew.
Western modern medicine treatment duck aspergillosis, disease is controlled rear easy recurrence, and resultant anti-stress, the physiological function such as anti-disease and food meat quality (quality) decline greatly, medicament residue is constantly rising.
Traditional Chinese medicine not only has the advantage of Western medicine, and cure rate is high, pollution-free, can strengthen duck immunity, after curing, is difficult for recurrence, and cost price is individual cheap.Therefore, Chinese herbal medicine is being of great practical significance aspect treatment duck aspergillosis disease.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of to comprise for preventing and treating the feed of the Chinese medicine composition of duck aspergillosis, the feed that employing contains this Chinese medicine composition can overcome the defect of prior art Chinese and Western medicine and Chinese medicine, treatment duck aspergillosis short treating period, medicament residue is few, reduces toxicity, and cure rate is high, pollution-free, can eliminating dampness and eliminating phlegmly relieving asthma, regulate the flow of vital energy, strengthen duck immunity, after curing, be difficult for recurrence, cost price is cheap.
In order to realize foregoing invention object, the invention provides a kind of for preventing and treating the feed of duck aspergillosis, comprise basal feed, trace mineral supplement, vitamin(e) supplement and Chinese medicine additive, Chinese medicine additive comprises Bulbus Fritillariae Cirrhosae, bamboo juice, Tabasheer, balloonflower root, perilla seed, birthwort, lepidium seed, ardisia japonica, datura flower, the root of large-flowered skullcap, the coptis, kuh-seng, barberry, manyleaf meadowure rhizome and root, the root bark of white mulberry, indigo naturalis, bark of ash, dried orange peel, citron, Rhododendron dauricum, thorny elaeagnus leaf, Radix Codonopsis, Chinese yam, Psoralea corylifolia, common perilla leaf and Artemisia capillaris.
In described Chinese medicine additive, the ratio of weight and number of each bulk drug is: Bulbus Fritillariae Cirrhosae 22-38 weight portion, bamboo juice 8-22 weight portion, Tabasheer 14-27 weight portion, balloonflower root 12-28 weight portion, perilla seed 24-39 weight portion, birthwort 15-32 weight portion, lepidium seed 7-22 weight portion, ardisia japonica 11-25 weight portion, datura flower 21-35 weight portion, root of large-flowered skullcap 25-40 weight portion, coptis 22-36 weight portion, kuh-seng 12-29 weight portion, barberry 18-31 weight portion, manyleaf meadowure rhizome and root 8-20 weight portion, root bark of white mulberry 25-36 weight portion, indigo naturalis 13-29 weight portion, bark of ash 25-40 weight portion, dried orange peel 15-30 weight portion, citron 12-26 weight portion, Rhododendron dauricum 10-25 weight portion, thorny elaeagnus leaf 26-37 weight portion, Radix Codonopsis 10-25 weight portion, Chinese yam 18-33 weight portion, Psoralea corylifolia 15-35 weight portion, common perilla leaf 10-26 weight portion and Artemisia capillaris 20-38 weight portion.
In described feed, the weight fraction of each composition ratio is: basal feed 100 weight portions, trace mineral supplement 0.001-0.01 weight portion, vitamin(e) supplement 0.0001-0.0007 weight portion and Chinese medicine additive 15-30 weight portion.
Described basal feed comprises one or more mixing in corn, dregs of beans, wheat bran.
In described basal feed, the ratio of weight and number of each component is: corn 50-70 part, dregs of beans 30-50 part, wheat bran 30-45 part.
Described trace mineral supplement comprises one or more mixing in iron, manganese, zinc, copper.
Described vitamin(e) supplement comprises one or more mixing in vitamin E, vitamin D, vitamin A.
In described Chinese medicine additive, the ratio of weight and number of each bulk drug is: Bulbus Fritillariae Cirrhosae 25-35 weight portion, bamboo juice 10-20 weight portion, Tabasheer 15-25 weight portion, balloonflower root 14-26 weight portion, perilla seed 26-36 weight portion, birthwort 17-30 weight portion, lepidium seed 7-18 weight portion, ardisia japonica 11-20 weight portion, datura flower 24-35 weight portion, root of large-flowered skullcap 27-37 weight portion, coptis 25-31 weight portion, kuh-seng 12-23 weight portion, barberry 20-30 weight portion, manyleaf meadowure rhizome and root 8-16 weight portion, root bark of white mulberry 27-34 weight portion, indigo naturalis 13-24 weight portion, bark of ash 27-36 weight portion, dried orange peel 18-26 weight portion, citron 14-23 weight portion, Rhododendron dauricum 10-21 weight portion, thorny elaeagnus leaf 28-35 weight portion, Radix Codonopsis 12-22 weight portion, Chinese yam 20-30 weight portion, Psoralea corylifolia 17-31 weight portion, common perilla leaf 12-23 weight portion and Artemisia capillaris 22-35 weight portion.
In described Chinese medicine additive, the ratio of weight and number of each bulk drug is: Bulbus Fritillariae Cirrhosae 27-32 weight portion, bamboo juice 12-18 weight portion, Tabasheer 17-22 weight portion, balloonflower root 16-23 weight portion, perilla seed 28-34 weight portion, birthwort 20-27 weight portion, lepidium seed 7-14 weight portion, ardisia japonica 11-16 weight portion, datura flower 25-32 weight portion, root of large-flowered skullcap 29-34 weight portion, coptis 27-29 weight portion, kuh-seng 12-20 weight portion, barberry 22-28 weight portion, manyleaf meadowure rhizome and root 8-14 weight portion, root bark of white mulberry 27-32 weight portion, indigo naturalis 13-21 weight portion, bark of ash 27-33 weight portion, dried orange peel 19-25 weight portion, citron 16-21 weight portion, Rhododendron dauricum 12-19 weight portion, thorny elaeagnus leaf 28-34 weight portion, Radix Codonopsis 14-20 weight portion, Chinese yam 22-28 weight portion, Psoralea corylifolia 19-27 weight portion, common perilla leaf 14-20 weight portion and Artemisia capillaris 25-33 weight portion.
It is a kind of for preventing and treating the preparation method of the feed of duck aspergillosis that the present invention also provides, and comprises the following steps:
The first step, is ground into 100-140 object powder by basal feed composition;
Second step, each bulk drug in described Chinese medicine additive is mixed in proportion, carry out charcoal and fry 60-90 minute, adding subsequently with respect to mixture quality 4-5 determining alcohol is doubly 71%-88% ethanolic solution, heating and refluxing extraction 1.5-3.0 hour, obtain the first extract, filter, obtain the first filtered fluid, it is 74%-82% ethanolic solution that filter residue adds with respect to its quality 3-5 determining alcohol doubly again, heating and refluxing extraction 1.5 hours, obtain the second extract, filter, obtain the second filtered fluid, filtered fluid is merged, reduced pressure concentration is removed ethanol, obtain dry lotion, adopt subsequently pulverizer to pulverize, grinding particle size 295-340 order, obtain pulverous described mixture of Chinese herbal medicines additive,
The 3rd step, the mixture of Chinese herbal medicines additive that the basal feed that the first step is obtained, second step obtain, trace element mixture additive, vitamin mixtures additive drop in mixer and mix, send in modem and pass into the steam modulation 5-12 minute of 94-103 ℃, then at the temperature of 106-113 ℃, enter extrusion granulator and granulate;
The 4th step, the pellet after granulating is cooling, obtain described duck feed.
It is a kind of for preventing and treating the Chinese medicine composition of duck aspergillosis that the present invention also provides, in Chinese medicine composition, the ratio of weight and number of each bulk drug is: Bulbus Fritillariae Cirrhosae 22-38 weight portion, bamboo juice 8-22 weight portion, Tabasheer 14-27 weight portion, balloonflower root 12-28 weight portion, perilla seed 24-39 weight portion, birthwort 15-32 weight portion, lepidium seed 7-22 weight portion, ardisia japonica 11-25 weight portion, datura flower 21-35 weight portion, root of large-flowered skullcap 25-40 weight portion, coptis 22-36 weight portion, kuh-seng 12-29 weight portion, barberry 18-31 weight portion, manyleaf meadowure rhizome and root 8-20 weight portion, root bark of white mulberry 25-36 weight portion, indigo naturalis 13-29 weight portion, bark of ash 25-40 weight portion, dried orange peel 15-30 weight portion, citron 12-26 weight portion, Rhododendron dauricum 10-25 weight portion, thorny elaeagnus leaf 26-37 weight portion, Radix Codonopsis 10-25 weight portion, Chinese yam 18-33 weight portion, Psoralea corylifolia 15-35 weight portion, common perilla leaf 10-26 weight portion and Artemisia capillaris 20-38 weight portion.
The preparation method of described Chinese traditional medicine composition composition powders comprises:
The first step, each component in described Chinese medicine composition is mixed in proportion, and input pulverizer is pulverized or directly chopping, packs into and decocts in container, add suitable quantity of water to make its submergence medicinal material, soak after 10-25 minute, be heated to seethe with excitement after 40-70 minute, separated fried liquid, the dregs of a decoction again add water and decoct 2-3 time, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filter residue;
Second step, after filtrate is cooling, adding with respect to liquid weight 1-2 determining alcohol doubly after concentrated is 80-90% ethanol, fully mix, placement is spent the night, and makes its precipitation, after getting its supernatant liquid filtering next day, obtain filtrate, the ethanol that sediment is 50-60% with determining alcohol is cleaned, and collects washing lotion and merges with filtrate, decompression is regained after ethanol, and dislocation lets cool place, standing 0.5-1 hour, make precipitation completely, filter, filtrate low-temperature evaporation, obtains paste;
The 3rd step: paste is put into spray dryer dry, guarantee that EAT is at 180 ℃-200 ℃, 70 ℃-90 ℃ of leaving air temps, are ground into 300 order-400 orders subsequently, obtain Powdered Chinese medicine composition.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is that duck feed of the present invention contains Chinese medicine additive, treatment duck aspergillosis short treating period, medicament residue is few, reduce toxicity, and cure rate is high, pollution-free, can eliminating dampness and eliminating phlegmly relieving asthma, regulate the flow of vital energy, strengthen duck immunity, after curing, be difficult for recurrence, cost price is cheap.
The specific embodiment
Chinese veterinarian thinks, duck aspergillosis is because Si Shi village gas is different, thereby the outer heresy of causing a disease that body is experienced is also had any different.Wind is first of the six external factors which cause diseases, and other are outer evil many with ailment said due to cold or exposure invasion and attack body, so diseases caused by external factors Chang Yifeng be guide, or holds under the arm coldly, or holds heat under the arm, or holds under the arm dryly, wherein especially with ailment said due to cold or exposure, holds the person that trembles with fear under the arm in the majority.Lung governing qi, its position is the highest, is the canopy of the five internal organs, and lung is had one's ideas straightened out again in nose, closes fur outward, and therefore lung is subject to the heresy of diseases caused by external factors, internal injury most, and lung is for tender dirty, and not resistance to heresy is invaded, and heresy invades that lung qi is unclear, loses in respectful and falls.Diseases caused by external factors are the outer evil lung of violating, and due to sluggishness of lung-QI is smooth, its pathological factor is wind, cold, heat, wet, dry, fiery, take chill as many, in pathological process, chill heat-transmission can occur, wind-heat dryness-transformation, or lung heat steaming liquid becomes the pathology such as phlegm to transform.Can influence each other as disease, disease for a long time the domination of pathogen transfer to weakened body resistance.Empty from real-turn for a long time, lungs are weak, deficiency of YIN leading to consumption of QI.
Therefore select Chinese herbal medicine: Bulbus Fritillariae Cirrhosae, bamboo juice, Tabasheer, balloonflower root, perilla seed, birthwort, lepidium seed, ardisia japonica, datura flower, the root of large-flowered skullcap, the coptis, kuh-seng, barberry, manyleaf meadowure rhizome and root, the root bark of white mulberry, indigo naturalis, bark of ash, dried orange peel, citron, Rhododendron dauricum, thorny elaeagnus leaf, Radix Codonopsis, Chinese yam, Psoralea corylifolia, common perilla leaf and Artemisia capillaris.
Wherein, Bulbus Fritillariae Cirrhosae taste bitter cold in nature, can reduce phlegm by eliminating heat from the lung, can sweet matter profit can moisten the lung and relieve the cough again; Bamboo juice, Tabasheer clear heat and eliminate phlegm, the sharp key of calming the frightened; Balloonflower root a surname lung, eliminate the phlegm, relieve sore throat, apocenosis; Perilla seed, birthwort lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma; Lepidium seed is specially let out water drink and convulsive seizure due to phlegm-fire in lung and is relievingd asthma and cough; Ardisia japonica is relieving cough and asthma, clearing heat and promoting diuresis; Datura flower antiasthmatic-antitussive, analgesia, convulsion only; The root of large-flowered skullcap, the coptis, barberry, manyleaf meadowure rhizome and root heat-clearing and damp-drying drug, purging intense heat and detonicating, compatibility indigo naturalis, the root bark of white mulberry; Kuh-seng heat-clearing and damp-drying drug, desinsection; Bark of ash is removed obstruction in channels to relieve pain, reducing the asthenic fever, clearing away damp-heat; Dried orange peel is eliminating dampness and eliminating phlegm, regulate the flow of vital energy; Citron regulating the flow of Qi and the middle Jiao, eliminating dampness and eliminating phlegm; Rhododendron dauricum expelling phlegm and arresting coughing is relievingd asthma; Thorny elaeagnus leaf antiasthmatic-antitussive, removing toxic substances; Radix Codonopsis, Chinese yam tonifying lung gas, lung-yin nourishing; Psoralea corylifolia warming kidney and enhancing yang, receives gas, antidiarrheal; Common perilla leaf dispelling wind a surname lung; Artemisia capillaris clearing heat and promoting diuresis.
The invention provides a kind of for preventing and treating feed, Chinese medicine composition and the preparation method of duck aspergillosis, comprise basal feed, trace mineral supplement, vitamin(e) supplement and Chinese medicine additive, Chinese medicine additive comprises Bulbus Fritillariae Cirrhosae, bamboo juice, Tabasheer, balloonflower root, perilla seed, birthwort, lepidium seed, ardisia japonica, datura flower, the root of large-flowered skullcap, the coptis, kuh-seng, barberry, manyleaf meadowure rhizome and root, the root bark of white mulberry, indigo naturalis, bark of ash, dried orange peel, citron, Rhododendron dauricum, thorny elaeagnus leaf, Radix Codonopsis, Chinese yam, Psoralea corylifolia, common perilla leaf and Artemisia capillaris.
In Chinese medicine additive, the ratio of weight and number of each bulk drug is: Bulbus Fritillariae Cirrhosae 22-38 weight portion, bamboo juice 8-22 weight portion, Tabasheer 14-27 weight portion, balloonflower root 12-28 weight portion, perilla seed 24-39 weight portion, birthwort 15-32 weight portion, lepidium seed 7-22 weight portion, ardisia japonica 11-25 weight portion, datura flower 21-35 weight portion, root of large-flowered skullcap 25-40 weight portion, coptis 22-36 weight portion, kuh-seng 12-29 weight portion, barberry 18-31 weight portion, manyleaf meadowure rhizome and root 8-20 weight portion, root bark of white mulberry 25-36 weight portion, indigo naturalis 13-29 weight portion, bark of ash 25-40 weight portion, dried orange peel 15-30 weight portion, citron 12-26 weight portion, Rhododendron dauricum 10-25 weight portion, thorny elaeagnus leaf 26-37 weight portion, Radix Codonopsis 10-25 weight portion, Chinese yam 18-33 weight portion, Psoralea corylifolia 15-35 weight portion, common perilla leaf 10-26 weight portion and Artemisia capillaris 20-38 weight portion.
The pharmacology of each bulk drug is as follows:
The coptis: hardship, cold, nontoxic.The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel.Function heat-clearing and damp-drying drug, purging intense heat and detonicating.Full for damp and hot ruffian, vomiting acid regurgitation, rushes down dysentery, jaundice, and unconsciousness due to high fever, is longer than the fire of removing the heart-fire stomach, has the disappear merit of ruffian of preventing or arresting vomiting concurrently, can be used for treating the dysphoria and insomnia of internal heat due to prosperous, and blood-head is told nosebleed, hot eyes, toothache, quenches one's thirst, the carbuncle furunculosis that swells; Control eczema outward, wet sore, duct is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of prepared RHIZOMA COPTIDIS with vino is burning hot.
Kuh-seng: bitter, cold in nature.Return liver, kidney, large intestine, small intestinl channel, bladder, the heart channel of Hang-Shaoyin, urinary bladder channel.Can heat-clearing and damp-drying drug, desinsection, diuresis.For hot dysentery, have blood in stool, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy; Control trichomonas vaginitis outward.
The root of large-flowered skullcap: property is bitter, cold.Return lung, courage, spleen, large intestine, small intestinl channel.Can heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive, hypotensive.For damp-warm syndrome, the heat temperature evil of vomitting uncomfortable in chest, damp and hot ruffian is full, rushes down dysentery, jaundice, and cough with lung heat, high hot polydipsia, blood-head is told nosebleed, carbuncle sore tumefacting virus, fetal irritability.
Perilla seed: pungent, temperature.Return lung, large intestine channel.Sending down abnormally ascending dissolving phlegm, relieving cough and asthma, relax bowel.
Balloonflower root: bitter, pungent, property is flat.Return lung channel.There is a surname's lung, eliminate the phlegm, relieve sore throat, apocenosis, sharp the five internal organs, the effect that fills blood, mend the exhaustion or lesion of the five internal organs, foster the spirit of nobility.Cure mainly coughing with a lot of sputum, abscess of throat, lung carbuncle pyemesis, fullness in the chest and hypochondriac pain, dysentery stomachache, aphthae, red eye, swell pain, uroschesis.
Dried orange peel: nature and flavor are bitter, pungent, temperature.Return lung, the spleen channel.There is regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm function.Can be used for chest gastral cavity turgor, food is few vomits and diarrhoea, coughing with a lot of sputum.
Manyleaf meadowure rhizome and root: cold in nature, bitter is nontoxic.The thoughts of returning home, liver, courage, large intestine four warps.Heat-clearing and damp-drying drug, removing toxic substances.Control dysentery, enteritis, catarrhal jaundice, flu, measles, the carbuncle sore furuncle that swells, conjunctivitis.
Bulbus Fritillariae Cirrhosae: the large hardship of taste, cold in nature.Return lung, the heart, stomach, Liver Channel.Great order lung carbuncle lung withers, and coughs and breathes heavily, and spits blood, and mental disorder, falls most in bleeding from five sense organs or subcutaneous tissue, kind relieving stagnation, and the pain that relieves the pain, dissipate-swelling is full, clearing away the liver-fire, improve visual and auditory acuity, gas dysphoria with smothery sensation while removing, jaundice is drenched and is closed, the excessive blood of having blood in stool; Relieving heat toxin, kills parasites and treats larynx numbness, scrofula, and acute mastitis carbuncle on the back, all large carbuncle pyogenic infections, damp and hot evil sore, anal fistula, metal-inflicted wound is hemorrhage, fiery sore pain, than Bulbus Fritillariae Cirrhosae, the merit of falling clearly, not less than several times.
Bamboo juice: sweetness and bitterness, cold.The thoughts of returning home, stomach warp.Fire falls in the wind that disappears, and moisturizes row phlegm, and the benefit that nourishes blood is cloudy, sharp key tomorrow.Control middle air port and keep silent, the large heat of phlegm fan, wind convulsion is demented, and unhappiness is quenched one's thirst, spontaneous sweating due to deficientcy of blood.Be mainly used in controlling apoplexy phlegm fan, lung heat phlegm is stopped up, infantile convulsion, epilepsy, high fever polydipsia, restlessness during pregnancy, lockjaw.
Tabasheer: sweet, cold.The thoughts of returning home, liver, lung channel.Control apoplexy phlegm and stop up, acute aphasia in silence, convulsive seizures induced by terror in children and epilepsy phlegm.Main child convulsion sky hangs, and all wind-heat are gone in relieving palpitation improving eyesight, treats metal-inflicted wound hemostasis, nourishes the five internal organs.Function clear heat and eliminate phlegm, cool heart arresting convulsion.Cure mainly pyreticosis coma delirium, apoplexy phlegm fan in silence, twitch, epilepsy by child convulsion.
Birthwort: bitter, cold nature.Return lung, large intestine channel.There is clearing lung-heat sending down abnormally ascending, relieving cough and asthma, the disappear effect of hemorrhoid of gut purge, for dyspnea and cough due to lung-heat, blood-stained sputum, the hot hemorrhoid blood of intestines, the cards such as hemorrhoid gall.
Ardisia japonica: property is flat, pungent, the micro-hardship of taste.Return lung, Liver Channel.Promoting blood circulation and stopping pain, diuresis, stomach invigorating, hemostasis.Control jaundice with damp-heat pathogen, hepatitis, acute nephritis, cystitis, pulmonary tuberculosis night sweat, spitting of blood, de-power internal lesion caused by overexertion, muscles and bones is ached, irregular menstruation, paranasal sinusitis.
Rhododendron dauricum: pungent, bitter, cold in nature.Return lung, the spleen channel.Cough-relieving; Eliminate the phlegm.Main acute and chronic bronchitis.
Radix Codonopsis: property is flat, sweet, the micro-acid of taste.Return spleen, lung channel.Tonifying middle-Jiao and Qi, invigorating the spleen benefit lung.For a little less than the spleen deficiency syndrome of the lung, the palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst.
Chinese yam: taste is sweet, property is flat.Return lung, spleen, kidney channel.Have strengthening the spleen and tonifying the lung, beneficial stomach kidney tonifying, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, the effect that helps the five internal organs, strengthening the bones and muscles, long will to calm the nerves, promote longevity, cure mainly that weakness of the spleen and the stomach, lassitude, poor appetite, chronic diarrhea and dysentery, Lung Qi deficiency are dry, asthma due to excessive phlegm cough, kidney qi loss, soreness and weakness of waist and knees, lower limb impotence are weak, the red card such as swollen, fat of gonorrhoea under the frequent micturition of quenching one's thirst, seminal emission premature ejaculation, band, skin.
Lepidium seed: pungent; Bitter; Cold.Gui Jing: lung channel; The heart channel of Hang-Shaoyin; Liver Channel; Stomach warp; Urinary bladder channel.Function: purging the lung of pathogenic fire sending down abnormally ascending; Eliminating phlegm and relieving asthma; Inducing diuresis for removing edema; Let out by heresy.Cure mainly: sputum is stopped up the dyspnea and cough with excessive sputum of lung; Lung carbuncle; Oedema; Chest abdomen ponding; Difficult urination; Chronic cor pulmonale; Breathing heavily of heart failure is swollen; Scrofula tuberculosis.
Datura flower: taste is pungent, warm in nature; Poisonous.The thoughts of returning home, lung, Liver Channel.Antiasthmatic-antitussive, analgesia, spasmolysis.For asthma and cough, coldness and pain in the epigastrium, arthralgia due to wind-dampness, children's is frightened slowly; Surgical anesthesia.
Indigo naturalis: nature and flavor: salty, cold.Gui Jing: enter Liver Channel, lung channel, stomach warp.Function: heat-clearing, blood cooling and ecchymoses removing, removing toxic substances, clearing liver-fire, arresting convulsion.Cure mainly: control warm disease heat and contain, macula, spits blood, spits blood, pediatric epilepsy scared, sore is swollen, erysipelas, snake bite and insect sting.
Bark of ash: pungent, bitter, flat.Return stomach, liver, gallbladder channel.Wines used as antirheumatic, clearing away damp-heat, stopping numbness pain.For arthralgia due to wind-dampness, the contraction of muscle arteries and veins, joint is ached, afternoon tidal fever, infantile malnutrition heating.
Citron: pungent; Bitter; Acid; Temperature.Return liver; Lung; The spleen channel.Cure mainly chest abdomen full vexed; The distending pain in hypochondrium; Coughing with a lot of sputum.
Thorny elaeagnus leaf: acid, flat, nontoxic.Return lung channel.Relieving cough and asthma; Hemostasis; Removing toxic substances.Main cough due to deficiency of the lung; Asthma; Hemoptysis; Spit blood; Traumatism and bleeding; Ulcer; Hemorrhoid gall.
Psoralea corylifolia: pungent, bitter, temperature.Return kidney, the spleen channel.Warming kidney and enhancing yang, receives gas, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, waist knee crymodynia, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External application curing vitiligo, alopecia areata.
Common perilla leaf: taste is pungent; Warm in nature.Return lung; The spleen channel.Dispelling wind a surname lung; Regulate the flow of vital energy and help digestion, solving toxin of fish and crab.Main cold; Cough and asthma; Gastral cavity abdominal distension is vexed; Accumulation of food in the stomach and intes tine due to indigestion; Vomit and diarrhoea; Cold dysentery; Middle fish crab poison; Man's swelling of vulva; Limb wind-puff poison; Snake bite and insect sting.
Artemisia capillaris: mildly bitter flavor; Micro-pungent; Cold nature.Return spleen; Stomach; Urinary bladder channel.Clearing heat and promoting diuresis; Removing jaundice.Main jaundice; Urine one profit; Wet sore itch.
In feed, the weight fraction of each composition ratio is: basal feed 100 weight portions, trace mineral supplement 0.001-0.01 weight portion, vitamin(e) supplement 0.0001-0.0007 weight portion and Chinese medicine additive 15-30 weight portion.
Basal feed comprises one or more mixing in corn, dregs of beans, wheat bran.
In basal feed, the ratio of weight and number of each component is: corn 50-70 part, dregs of beans 30-50 part, wheat bran 30-45 part.
Trace mineral supplement comprises one or more mixing in iron, manganese, zinc, copper.
Vitamin(e) supplement comprises one or more mixing in vitamin E, vitamin D, vitamin A.
In Chinese medicine additive, the ratio of weight and number of each bulk drug is: Bulbus Fritillariae Cirrhosae 25-35 weight portion, bamboo juice 10-20 weight portion, Tabasheer 15-25 weight portion, balloonflower root 14-26 weight portion, perilla seed 26-36 weight portion, birthwort 17-30 weight portion, lepidium seed 7-18 weight portion, ardisia japonica 11-20 weight portion, datura flower 24-35 weight portion, root of large-flowered skullcap 27-37 weight portion, coptis 25-31 weight portion, kuh-seng 12-23 weight portion, barberry 20-30 weight portion, manyleaf meadowure rhizome and root 8-16 weight portion, root bark of white mulberry 27-34 weight portion, indigo naturalis 13-24 weight portion, bark of ash 27-36 weight portion, dried orange peel 18-26 weight portion, citron 14-23 weight portion, Rhododendron dauricum 10-21 weight portion, thorny elaeagnus leaf 28-35 weight portion, Radix Codonopsis 12-22 weight portion, Chinese yam 20-30 weight portion, Psoralea corylifolia 17-31 weight portion, common perilla leaf 12-23 weight portion and Artemisia capillaris 22-35 weight portion.
In Chinese medicine additive, the ratio of weight and number of each bulk drug is: Bulbus Fritillariae Cirrhosae 27-32 weight portion, bamboo juice 12-18 weight portion, Tabasheer 17-22 weight portion, balloonflower root 16-23 weight portion, perilla seed 28-34 weight portion, birthwort 20-27 weight portion, lepidium seed 7-14 weight portion, ardisia japonica 11-16 weight portion, datura flower 25-32 weight portion, root of large-flowered skullcap 29-34 weight portion, coptis 27-29 weight portion, kuh-seng 12-20 weight portion, barberry 22-28 weight portion, manyleaf meadowure rhizome and root 8-14 weight portion, root bark of white mulberry 27-32 weight portion, indigo naturalis 13-21 weight portion, bark of ash 27-33 weight portion, dried orange peel 19-25 weight portion, citron 16-21 weight portion, Rhododendron dauricum 12-19 weight portion, thorny elaeagnus leaf 28-34 weight portion, Radix Codonopsis 14-20 weight portion, Chinese yam 22-28 weight portion, Psoralea corylifolia 19-27 weight portion, common perilla leaf 14-20 weight portion and Artemisia capillaris 25-33 weight portion.
It is a kind of for preventing and treating the preparation method of the feed of duck aspergillosis that the present invention also provides, and comprises the following steps:
The first step, is ground into 100-140 object powder by basal feed composition;
Second step, each bulk drug in described Chinese medicine additive is mixed in proportion, carry out charcoal and fry 60-90 minute, adding subsequently with respect to mixture quality 4-5 determining alcohol is doubly 71%-88% ethanolic solution, heating and refluxing extraction 1.5-3.0 hour, obtain the first extract, filter, obtain the first filtered fluid, it is 74%-82% ethanolic solution that filter residue adds with respect to its quality 3-5 determining alcohol doubly again, heating and refluxing extraction 1.5 hours, obtain the second extract, filter, obtain the second filtered fluid, filtered fluid is merged, reduced pressure concentration is removed ethanol, obtain dry lotion, adopt subsequently pulverizer to pulverize, grinding particle size 295-340 order, obtain pulverous described mixture of Chinese herbal medicines additive,
The 3rd step, the mixture of Chinese herbal medicines additive that the basal feed that the first step is obtained, second step obtain, trace element mixture additive, vitamin mixtures additive drop in mixer and mix, send in modem and pass into the steam modulation 5-12 minute of 94-103 ℃, then at the temperature of 106-113 ℃, enter extrusion granulator and granulate;
The 4th step, the pellet after granulating is cooling, obtain described duck feed.
It is a kind of for preventing and treating the Chinese medicine composition of duck aspergillosis that the present invention also provides, in Chinese medicine composition, the ratio of weight and number of each bulk drug is: Bulbus Fritillariae Cirrhosae 22-38 weight portion, bamboo juice 8-22 weight portion, Tabasheer 14-27 weight portion, balloonflower root 12-28 weight portion, perilla seed 24-39 weight portion, birthwort 15-32 weight portion, lepidium seed 7-22 weight portion, ardisia japonica 11-25 weight portion, datura flower 21-35 weight portion, root of large-flowered skullcap 25-40 weight portion, coptis 22-36 weight portion, kuh-seng 12-29 weight portion, barberry 18-31 weight portion, manyleaf meadowure rhizome and root 8-20 weight portion, root bark of white mulberry 25-36 weight portion, indigo naturalis 13-29 weight portion, bark of ash 25-40 weight portion, dried orange peel 15-30 weight portion, citron 12-26 weight portion, Rhododendron dauricum 10-25 weight portion, thorny elaeagnus leaf 26-37 weight portion, Radix Codonopsis 10-25 weight portion, Chinese yam 18-33 weight portion, Psoralea corylifolia 15-35 weight portion, common perilla leaf 10-26 weight portion and Artemisia capillaris 20-38 weight portion.
The preparation method of Chinese traditional medicine composition composition powders comprises:
The first step, each component in described Chinese medicine composition is mixed in proportion, and input pulverizer is pulverized or directly chopping, packs into and decocts in container, add suitable quantity of water to make its submergence medicinal material, soak after 10-25 minute, be heated to seethe with excitement after 40-70 minute, separated fried liquid, the dregs of a decoction again add water and decoct 2-3 time, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filter residue;
Second step, after filtrate is cooling, adding with respect to liquid weight 1-2 determining alcohol doubly after concentrated is 80-90% ethanol, fully mix, placement is spent the night, and makes its precipitation, after getting its supernatant liquid filtering next day, obtain filtrate, the ethanol that sediment is 50-60% with determining alcohol is cleaned, and collects washing lotion and merges with filtrate, decompression is regained after ethanol, and dislocation lets cool place, standing 0.5-1 hour, make precipitation completely, filter, filtrate low-temperature evaporation, obtains paste;
The 3rd step: paste is put into spray dryer dry, guarantee that EAT is at 180 ℃-200 ℃, 70 ℃-90 ℃ of leaving air temps, are ground into 300 order-400 orders subsequently, obtain Powdered Chinese medicine composition.
The toxicity test of embodiment 1 Chinese medicine composition of the present invention
Get Bulbus Fritillariae Cirrhosae 27g, bamboo juice 17g, Tabasheer 21g, balloonflower root 23g, perilla seed 29g, birthwort 25g, lepidium seed 7g, ardisia japonica 15g, datura flower 26g, root of large-flowered skullcap 29g, coptis 28g, kuh-seng 14g, barberry 22g, manyleaf meadowure rhizome and root 10g, root bark of white mulberry 31g, indigo naturalis 13g, bark of ash 27g, dried orange peel 23g, citron 21g, Rhododendron dauricum 15g, thorny elaeagnus leaf 29g, Radix Codonopsis 19g, Chinese yam 23g, Psoralea corylifolia 26g, common perilla leaf 14g and Artemisia capillaris 32g; After mixing, pulverize, the water to adding 1200g in the mixture after pulverizing, decocts 2.5 hours, filters, and adds the water of 500g again to decoct in filter residue 1.5 hours, filters, and by twice filtrate mixing, is evaporated to the decoction that crude drug concentration is 3g/ml.
Get ICR mouse, body weight is at 25-30 gram, by body weight random packet, and 10 every group, male and female half and half, oral administration solution administration, dosage is only 6.0ml/.After administration, Continuous Observation is 20 days, and all mouse of result are strong deposits, and its activity, diet, hair, excreta are no abnormal, have no toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, there are no irritative response and other bad reaction.
Toxicity test proves, the not toxic effect of this medicine and bad reaction, and clinical practice is safe and reliable.
Embodiment 2 Chinese medicine composition 1 of the present invention and preparation method
Get Bulbus Fritillariae Cirrhosae 32g, bamboo juice 12g, Tabasheer 19g, balloonflower root 16g, perilla seed 34g, birthwort 22g, lepidium seed 14g, ardisia japonica 16g, datura flower 30g, root of large-flowered skullcap 34g, coptis 27g, kuh-seng 19g, barberry 26g, manyleaf meadowure rhizome and root 14g, root bark of white mulberry 27g, indigo naturalis 19g, bark of ash 31g, dried orange peel 19g, citron 18g, Rhododendron dauricum 17g, thorny elaeagnus leaf 34g, Radix Codonopsis 18g, Chinese yam 22g, Psoralea corylifolia 27g, common perilla leaf 18g and Artemisia capillaris 33g; Dropping into pulverizer pulverizes, Chinese medicine composition after pulverizing is packed into and decocted in container, add suitable quantity of water to make its submergence medicinal material, soak after 10 minutes, be heated to seethe with excitement after 50 minutes, separated fried liquid, the dregs of a decoction again add water and decoct 3 times, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filter residue; After filtrate is cooling, adding the determining alcohol with respect to 1 times of liquid weight after concentrated is 80% ethanol, fully mixes, placement is spent the night, and makes its precipitation, obtains filtrate after getting its supernatant liquid filtering next day, the ethanol that sediment is 55% with determining alcohol is cleaned, and collects washing lotion and merges with filtrate, and decompression is regained after ethanol, dislocation lets cool place, standing 1 hour, make precipitation completely, filter, filtrate low-temperature evaporation, obtains paste; Paste is put into spray dryer dry, guarantee that EAT is at 180 ℃, 85 ℃ of leaving air temps, are ground into 300 orders subsequently, obtain Powdered Chinese medicine composition.
Embodiment 3 Chinese medicine composition 2 of the present invention and preparation method
Get Bulbus Fritillariae Cirrhosae 29g, bamboo juice 18g, Tabasheer 17g, balloonflower root 22g, perilla seed 28g, birthwort 27g, lepidium seed 8g, ardisia japonica 11g, datura flower 25g, root of large-flowered skullcap 33g, coptis 29g, kuh-seng 20g, barberry 28g, manyleaf meadowure rhizome and root 13g, root bark of white mulberry 29g, indigo naturalis 21g, bark of ash 29g, dried orange peel 25g, citron 20g, Rhododendron dauricum 12g, thorny elaeagnus leaf 28g, Radix Codonopsis 20g, Chinese yam 27g, Psoralea corylifolia 19g, common perilla leaf 16g and Artemisia capillaris 25g; Dropping into pulverizer pulverizes, Chinese medicine composition after pulverizing is packed into and decocted in container, add suitable quantity of water to make its submergence medicinal material, soak after 22 minutes, be heated to seethe with excitement after 70 minutes, separated fried liquid, the dregs of a decoction again add water and decoct 2 times, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filter residue; After filtrate is cooling, adding the determining alcohol with respect to 1 times of liquid weight after concentrated is 86% ethanol, fully mixes, placement is spent the night, and makes its precipitation, obtains filtrate after getting its supernatant liquid filtering next day, the ethanol that sediment is 60% with determining alcohol is cleaned, and collects washing lotion and merges with filtrate, and decompression is regained after ethanol, dislocation lets cool place, standing 0.8 hour, make precipitation completely, filter, filtrate low-temperature evaporation, obtains paste; Paste is put into spray dryer dry, guarantee that EAT is at 195 ℃, 80 ℃ of leaving air temps, are ground into 400 orders subsequently, obtain Powdered Chinese medicine composition.
Embodiment 4 Chinese medicine composition 3 of the present invention and preparation method
Get Bulbus Fritillariae Cirrhosae 30g, bamboo juice 14g, Tabasheer 22g, balloonflower root 18g, perilla seed 32g, birthwort 20g, lepidium seed 12g, ardisia japonica 13g, datura flower 32g, root of large-flowered skullcap 31g, coptis 27g, kuh-seng 12g, barberry 23g, manyleaf meadowure rhizome and root 8g, root bark of white mulberry 32g, indigo naturalis 15g, bark of ash 33g, dried orange peel 21g, citron 16g, Rhododendron dauricum 19g, thorny elaeagnus leaf 32g, Radix Codonopsis 14g, Chinese yam 28g, Psoralea corylifolia 21g, common perilla leaf 20g and Artemisia capillaris 28g; Dropping into pulverizer pulverizes, Chinese medicine composition after pulverizing is packed into and decocted in container, add suitable quantity of water to make its submergence medicinal material, soak after 10 minutes, be heated to seethe with excitement after 40 minutes, separated fried liquid, the dregs of a decoction again add water and decoct 3 times, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filter residue; After filtrate is cooling, adding the determining alcohol with respect to 1 times of liquid weight after concentrated is 83% ethanol, fully mixes, placement is spent the night, and makes its precipitation, obtains filtrate after getting its supernatant liquid filtering next day, the ethanol that sediment is 54% with determining alcohol is cleaned, and collects washing lotion and merges with filtrate, and decompression is regained after ethanol, dislocation lets cool place, standing 0.5 hour, make precipitation completely, filter, filtrate low-temperature evaporation, obtains paste; Paste is put into spray dryer dry, guarantee that EAT is at 200 ℃, 80 ℃ of leaving air temps, are ground into 400 orders subsequently, obtain Powdered Chinese medicine composition.
Embodiment 5 feed 1 of the present invention and preparation method
A kind of feed, comprise basal feed, trace mineral supplement, vitamin(e) supplement and Chinese medicine additive, its ratio of weight and number is 100 weight portions: 0.008 weight portion: 0.0005 weight portion: 25 weight portions, wherein in basal feed, each component agent weight is corn 7000g, dregs of beans 3500g, wheat bran 4000g, wherein, trace mineral supplement is the mixture of iron, manganese, zinc and copper, wherein in Chinese medicine additive, the parts by weight of each bulk drug are: Bulbus Fritillariae Cirrhosae 32 weight portions, bamboo juice 12 weight portions, Tabasheer 19 weight portions, balloonflower root 16 weight portions, perilla seed 34 weight portions, birthwort 22 weight portions, lepidium seed 14 weight portions, ardisia japonica 16 weight portions, datura flower 30 weight portions, the root of large-flowered skullcap 34 weight portions, the coptis 27 weight portions, kuh-seng 19 weight portions, barberry 26 weight portions, manyleaf meadowure rhizome and root 14 weight portions, the root bark of white mulberry 27 weight portions, indigo naturalis 19 weight portions, bark of ash 31 weight portions, dried orange peel 19 weight portions, citron 18 weight portions, Rhododendron dauricum 17 weight portions, thorny elaeagnus leaf 34 weight portions, Radix Codonopsis 18 weight portions, Chinese yam 22 weight portions, Psoralea corylifolia 27 weight portions, common perilla leaf 18 weight portions and Artemisia capillaris 33 weight portions.
The preparation method of feed is as follows:
The first step, is ground into 120 object powder by basal feed;
Second step, each bulk drug in described Chinese medicine additive is mixed in proportion, carrying out charcoal fries 70 minutes, adding subsequently the determining alcohol with respect to 4 times of mixture qualities is 80% ethanolic solution, heating and refluxing extraction 2 hours, obtain the first extract, filter, obtain the first filtered fluid, it is 78% ethanolic solution that filter residue adds the determining alcohol with respect to 3 times of its quality again, heating and refluxing extraction 1.5 hours, obtain the second extract, filter, obtain the second filtered fluid, filtered fluid is merged, reduced pressure concentration is removed ethanol, obtain dry lotion, adopt subsequently pulverizer to pulverize, grinding particle size 340 orders, obtain pulverous described Chinese medicine additive,
The 3rd step, the mixture of Chinese herbal medicines additive that the basal feed that the first step is obtained, second step obtain, trace element mixture additive, vitamin mixtures additive drop in mixer and mix, send into the steam modulation 8 minutes that passes into 100 ℃ in modem, then at the temperature of 108 ℃, enter extrusion granulator and granulate;
The 4th step, the pellet after granulating is cooling, obtain described duck feed.
Embodiment 6 feed 2 of the present invention and preparation method
A kind of feed, comprise basal feed, trace mineral supplement, vitamin(e) supplement and Chinese medicine additive, its ratio of weight and number is 100 weight portions: 0.08 weight portion: 0.0006 weight portion: 30 weight portions, wherein in basal feed, each component agent weight is corn 6000g, dregs of beans 5000g, wheat bran 3500g, wherein, trace mineral supplement is the mixture of magnesium, iron and potassium, wherein in Chinese medicine additive, the parts by weight of each bulk drug are: Bulbus Fritillariae Cirrhosae 29 weight portions, bamboo juice 18 weight portions, Tabasheer 17 weight portions, balloonflower root 22 weight portions, perilla seed 28 weight portions, birthwort 27 weight portions, lepidium seed 8 weight portions, ardisia japonica 11 weight portions, datura flower 25 weight portions, the root of large-flowered skullcap 33 weight portions, the coptis 29 weight portions, kuh-seng 20 weight portions, barberry 28 weight portions, manyleaf meadowure rhizome and root 13 weight portions, the root bark of white mulberry 29 weight portions, indigo naturalis 21 weight portions, bark of ash 29 weight portions, dried orange peel 25 weight portions, citron 20 weight portions, Rhododendron dauricum 12 weight portions, thorny elaeagnus leaf 28 weight portions, Radix Codonopsis 20 weight portions, Chinese yam 27 weight portions, Psoralea corylifolia 19 weight portions, common perilla leaf 16 weight portions and Artemisia capillaris 25 weight portions.
The preparation method of feed is as follows:
The first step, is ground into 140 object powder by basal feed composition;
Second step, each bulk drug in described Chinese medicine additive is mixed in proportion, carrying out charcoal fries 90 minutes, adding subsequently the determining alcohol with respect to 5 times of mixture qualities is 88% ethanolic solution, heating and refluxing extraction 3.0 hours, obtain the first extract, filter, obtain the first filtered fluid, it is 82% ethanolic solution that filter residue adds the determining alcohol with respect to 3 times of its quality again, heating and refluxing extraction 1.5 hours, obtain the second extract, filter, obtain the second filtered fluid, filtered fluid is merged, reduced pressure concentration is removed ethanol, obtain dry lotion, adopt subsequently pulverizer to pulverize, grinding particle size 295 orders, obtain pulverous described mixture of Chinese herbal medicines additive,
The 3rd step, the mixture of Chinese herbal medicines additive that the basal feed that the first step is obtained, second step obtain, trace element mixture additive, vitamin mixtures additive drop in mixer and mix, send into the steam modulation 5 minutes that passes into 103 ℃ in modem, then at the temperature of 106 ℃, enter extrusion granulator and granulate;
The 4th step, the pellet after granulating is cooling, obtain described duck feed.
Embodiment 7 clinical testings
(1) material is prepared
Kaiyuan City duckery, there is aspergillosis symptom in various degree in the duckling of three duck sheds wherein, 300 of the ill ducks that random choose 15 ages in days have been made a definite diagnosis, as treatment contrast test object; 300 of the ducklings of another random crawl 7 age in days health, as prevention contrast test object.
(2) bacterial strain extracts:
40 ducks that die of illness in Kaiyuan City duckery are cutd open to inspection, get lung tissue typical cytopathic and be inoculated on Sab plating medium, after 36 hours, standby through 37 ℃ of cultivations.In culture, occur that the visible center of naked eyes is green with cigarette, slightly projection, periphery are scattering cilium sample bacterium colony, the visible colonies typical structure of microscopy, conidium is the columnar arrangement that typical case is fine and close, and top capsule is handstand flask sample, and mycelia is separated.
(3) prevention contrast test
300 ducklings of random choose are divided into 3 groups (control group 1, control group 2 and embodiment groups) at random, wherein, control group 1 and control group 2 are used respectively traditional duck feed meat duck of feeding, embodiment group is used the duck of feeding of the feed 1 in embodiment 4, feed after 7 days, control group 1 and embodiment group are carried out to artificial challenge and with standby culture, with physiological saline, make the suspension that contains spore, every milliliter containing 2,000,000 spores, via intranasal application inoculation, give 2 of every healthy duck inoculations, observed and recorded is respectively organized the incidence of disease and the death rate of duck, and result is as shown in table 1.
The table 1 preventive effect table of comparisons
Data from table 1: the feed that the present invention contains Chinese medicine composition has obvious preventive effect to duck aspergillosis.
(4) treatment contrast test:
The duck of 300 15 ages in days choosing is at random divided into 3 groups (treatment by Chinese herbs group, western medicine group, blank groups) at random, with different medicines, treat, wherein, treatment by Chinese herbs group is selected the Chinese medicine composition 3 of embodiment 4, dose is weight portion every every day 0.5, is used in conjunction 5 days; Western medicine group is taken nystatin orally, 10,000 units/only, and 1 times/day, be used in conjunction 5 days, drink 1:3000CuSO simultaneously
4water; Blank group is not fed any medicine.Observed and recorded is respectively organized cure rate and the death rate of duck, and result is as shown in table 2.
The table 2 result for the treatment of table of comparisons
Data from table 2: Chinese medicine composition of the present invention is obviously better than western medicine group to the result for the treatment of of duck aspergillosis, reduce the death rate, improve cure rate.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. for preventing and treating a feed for duck aspergillosis, it is characterized in that, comprise basal feed, trace mineral supplement, vitamin(e) supplement and Chinese medicine additive, in described Chinese medicine additive, the ratio of weight and number of each bulk drug is: Bulbus Fritillariae Cirrhosae 22-38 weight portion, bamboo juice 8-22 weight portion, Tabasheer 14-27 weight portion, balloonflower root 12-28 weight portion, perilla seed 24-39 weight portion, birthwort 15-32 weight portion, lepidium seed 7-22 weight portion, ardisia japonica 11-25 weight portion, datura flower 21-35 weight portion, root of large-flowered skullcap 25-40 weight portion, coptis 22-36 weight portion, kuh-seng 12-29 weight portion, barberry 18-31 weight portion, manyleaf meadowure rhizome and root 8-20 weight portion, root bark of white mulberry 25-36 weight portion, indigo naturalis 13-29 weight portion, bark of ash 25-40 weight portion, dried orange peel 15-30 weight portion, citron 12-26 weight portion, Rhododendron dauricum 10-25 weight portion, thorny elaeagnus leaf 26-37 weight portion, Radix Codonopsis 10-25 weight portion, Chinese yam 18-33 weight portion, Psoralea corylifolia 15-35 weight portion, common perilla leaf 10-26 weight portion and Artemisia capillaris 20-38 weight portion.
2. according to claim 1 for preventing and treating the feed of duck aspergillosis, it is characterized in that, in described feed, the weight fraction of each composition ratio is: basal feed 100 weight portions, trace mineral supplement 0.001-0.01 weight portion, vitamin(e) supplement 0.0001-0.0007 weight portion and Chinese medicine additive 15-30 weight portion.
3. according to claim 1ly for preventing and treating the feed of duck aspergillosis, it is characterized in that, described basal feed comprises one or more mixing in corn, dregs of beans, wheat bran.
4. according to claim 1ly for preventing and treating the feed of duck aspergillosis, it is characterized in that, described trace mineral supplement comprises one or more mixing in iron, manganese, zinc, copper.
5. arbitrary described for preventing and treating the feed of duck aspergillosis according to claim 1-4, it is characterized in that, described vitamin(e) supplement comprises one or more mixing in vitamin E, vitamin D, vitamin A.
6. arbitrary described for preventing and treating the feed of duck aspergillosis according to claim 1-4, it is characterized in that, in described Chinese medicine additive, the ratio of weight and number of each bulk drug is: Bulbus Fritillariae Cirrhosae 25-35 weight portion, bamboo juice 10-20 weight portion, Tabasheer 15-25 weight portion, balloonflower root 14-26 weight portion, perilla seed 26-36 weight portion, birthwort 17-30 weight portion, lepidium seed 7-18 weight portion, ardisia japonica 11-20 weight portion, datura flower 24-35 weight portion, root of large-flowered skullcap 27-37 weight portion, coptis 25-31 weight portion, kuh-seng 12-23 weight portion, barberry 20-30 weight portion, manyleaf meadowure rhizome and root 8-16 weight portion, root bark of white mulberry 27-34 weight portion, indigo naturalis 13-24 weight portion, bark of ash 27-36 weight portion, dried orange peel 18-26 weight portion, citron 14-23 weight portion, Rhododendron dauricum 10-21 weight portion, thorny elaeagnus leaf 28-35 weight portion, Radix Codonopsis 12-22 weight portion, Chinese yam 20-30 weight portion, Psoralea corylifolia 17-31 weight portion, common perilla leaf 12-23 weight portion and Artemisia capillaris 22-35 weight portion.
7. arbitrary described for preventing and treating the feed of duck aspergillosis according to claim 1-4, it is characterized in that, in described Chinese medicine additive, the ratio of weight and number of each bulk drug is: Bulbus Fritillariae Cirrhosae 27-32 weight portion, bamboo juice 12-18 weight portion, Tabasheer 17-22 weight portion, balloonflower root 16-23 weight portion, perilla seed 28-34 weight portion, birthwort 20-27 weight portion, lepidium seed 7-14 weight portion, ardisia japonica 11-16 weight portion, datura flower 25-32 weight portion, root of large-flowered skullcap 29-34 weight portion, coptis 27-29 weight portion, kuh-seng 12-20 weight portion, barberry 22-28 weight portion, manyleaf meadowure rhizome and root 8-14 weight portion, root bark of white mulberry 27-32 weight portion, indigo naturalis 13-21 weight portion, bark of ash 27-33 weight portion, dried orange peel 19-25 weight portion, citron 16-21 weight portion, Rhododendron dauricum 12-19 weight portion, thorny elaeagnus leaf 28-34 weight portion, Radix Codonopsis 14-20 weight portion, Chinese yam 22-28 weight portion, Psoralea corylifolia 19-27 weight portion, common perilla leaf 14-20 weight portion and Artemisia capillaris 25-33 weight portion.
8. arbitrary described for preventing and treating the preparation method of the feed of duck aspergillosis according to claim 1-4, it is characterized in that, comprise the following steps:
The first step, is ground into 100-140 object powder by basal feed composition;
Second step, each bulk drug in described Chinese medicine additive is mixed in proportion, carry out charcoal and fry 60-90 minute, adding subsequently with respect to mixture quality 4-5 determining alcohol is doubly 71%-88% ethanolic solution, heating and refluxing extraction 1.5-3.0 hour, obtain the first extract, filter, obtain the first filtered fluid, it is 74%-82% ethanolic solution that filter residue adds with respect to its quality 3-5 determining alcohol doubly again, heating and refluxing extraction 1.5 hours, obtain the second extract, filter, obtain the second filtered fluid, filtered fluid is merged, reduced pressure concentration is removed ethanol, obtain dry lotion, adopt subsequently pulverizer to pulverize, grinding particle size 295-340 order, obtain pulverous described mixture of Chinese herbal medicines additive,
The 3rd step, the mixture of Chinese herbal medicines additive that the basal feed that the first step is obtained, second step obtain, trace element mixture additive, vitamin mixtures additive drop in mixer and mix, send in modem and pass into the steam modulation 5-12 minute of 94-103 ℃, then at the temperature of 106-113 ℃, enter extrusion granulator and granulate;
The 4th step, the pellet after granulating is cooling, obtain described duck feed.
9. one kind for preventing and treating the Chinese medicine composition of duck aspergillosis, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each bulk drug is: Bulbus Fritillariae Cirrhosae 22-38 weight portion, bamboo juice 8-22 weight portion, Tabasheer 14-27 weight portion, balloonflower root 12-28 weight portion, perilla seed 24-39 weight portion, birthwort 15-32 weight portion, lepidium seed 7-22 weight portion, ardisia japonica 11-25 weight portion, datura flower 21-35 weight portion, root of large-flowered skullcap 25-40 weight portion, coptis 22-36 weight portion, kuh-seng 12-29 weight portion, barberry 18-31 weight portion, manyleaf meadowure rhizome and root 8-20 weight portion, root bark of white mulberry 25-36 weight portion, indigo naturalis 13-29 weight portion, bark of ash 25-40 weight portion, dried orange peel 15-30 weight portion, citron 12-26 weight portion, Rhododendron dauricum 10-25 weight portion, thorny elaeagnus leaf 26-37 weight portion, Radix Codonopsis 10-25 weight portion, Chinese yam 18-33 weight portion, Psoralea corylifolia 15-35 weight portion, common perilla leaf 10-26 weight portion and Artemisia capillaris 20-38 weight portion.
10. according to claim 7ly for preventing and treating the Chinese medicine composition of duck aspergillosis, it is characterized in that, the preparation method of described Chinese traditional medicine composition composition powders comprises:
The first step: each component in described Chinese medicine composition is mixed in proportion, input pulverizer is pulverized or directly chopping, pack into and decoct in container, add suitable quantity of water to make its submergence medicinal material, soak after 10-25 minute, be heated to seethe with excitement after 40-70 minute, separated fried liquid, the dregs of a decoction again add water and decoct 2-3 time, the fried liquid that separated and collected is each, after filtering, get filtrate and abandon filter residue again;
Second step: after filtrate is cooling, adding with respect to liquid weight 1-2 determining alcohol doubly after concentrated is 80-90% ethanol, fully mixes, placement is spent the night, and makes its precipitation, obtains filtrate after getting its supernatant liquid filtering next day, the ethanol that sediment is 50-60% with determining alcohol is cleaned, and collects washing lotion and merges with filtrate, and decompression is regained after ethanol, dislocation lets cool place, standing 0.5-1 hour, makes precipitation completely, filters, filtrate low-temperature evaporation, obtains paste;
The 3rd step: paste is put into spray dryer dry, guarantee that EAT is at 180 ℃-200 ℃, 70 ℃-90 ℃ of leaving air temps, are ground into 300 order-400 orders subsequently, obtain Powdered Chinese medicine composition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410200627.1A CN103947893B (en) | 2014-05-14 | 2014-05-14 | A kind of feed, Chinese medicine composition and preparation method for preventing and treating duck aspergillosis |
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| CN201410200627.1A CN103947893B (en) | 2014-05-14 | 2014-05-14 | A kind of feed, Chinese medicine composition and preparation method for preventing and treating duck aspergillosis |
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| CN201410200627.1A Active CN103947893B (en) | 2014-05-14 | 2014-05-14 | A kind of feed, Chinese medicine composition and preparation method for preventing and treating duck aspergillosis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111838417A (en) * | 2020-07-31 | 2020-10-30 | 李志刚 | Traditional Chinese medicine feed additive and feed for preventing and treating respiratory system diseases of livestock and poultry and preparation method thereof |
| CN113068767A (en) * | 2021-03-30 | 2021-07-06 | 中国热带农业科学院热带生物技术研究所 | Application of sarmentosum bungei extract in preparation of additive for preventing and treating avian aspergillosis |
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| CN101342275A (en) * | 2008-08-25 | 2009-01-14 | 河北农业大学 | Medicament for preventing and controlling aspergillus disease of chicken |
| CN103006870A (en) * | 2011-09-26 | 2013-04-03 | 董根荣 | Oral liquid for controlling avian aspergillosis and preparation method thereof |
| CN103083524A (en) * | 2011-10-27 | 2013-05-08 | 天津生机集团股份有限公司 | Traditional Chinese medicine granules used for treating chicken aspergillosis, and preparation method thereof |
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| CN101342275A (en) * | 2008-08-25 | 2009-01-14 | 河北农业大学 | Medicament for preventing and controlling aspergillus disease of chicken |
| CN103006870A (en) * | 2011-09-26 | 2013-04-03 | 董根荣 | Oral liquid for controlling avian aspergillosis and preparation method thereof |
| CN103083524A (en) * | 2011-10-27 | 2013-05-08 | 天津生机集团股份有限公司 | Traditional Chinese medicine granules used for treating chicken aspergillosis, and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111838417A (en) * | 2020-07-31 | 2020-10-30 | 李志刚 | Traditional Chinese medicine feed additive and feed for preventing and treating respiratory system diseases of livestock and poultry and preparation method thereof |
| CN113068767A (en) * | 2021-03-30 | 2021-07-06 | 中国热带农业科学院热带生物技术研究所 | Application of sarmentosum bungei extract in preparation of additive for preventing and treating avian aspergillosis |
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| CN103947893B (en) | 2015-09-09 |
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Effective date of registration: 20171027 Address after: Nansha District Lanhe town Guangzhou city Guangdong province 511400 on ni cun Guang Zhu Lu No. 26 Patentee after: Guangzhou six Feed Co., Ltd. Address before: 266061 Shandong city of Qingdao province Chengyang Jihongtan Street Green Industrial Park Patentee before: Shandong New Hope Liuhe Group Co., Ltd. |
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Effective date of registration: 20190617 Address after: 266111 Airport Industrial Park, Shuangyuan Road, Liuting Street, Chengyang District, Qingdao City, Shandong Province, West Changjiang Road Patentee after: Shandong New Hope Liuhe Group Co., Ltd. Address before: 511400 Guangzhu Road, Nicun, Lanhe Town, Nansha District, Guangzhou City, Guangdong Province Patentee before: Guangzhou six Feed Co., Ltd. |
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