CN103566312B - Traditional Chinese medicine combination for treating loss of appetite of pigs - Google Patents
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Abstract
The invention relates to a traditional Chinese medicine combination for treating the loss of appetite of pigs and belongs to the technical field of veterinary medicines. The traditional Chinese medicine combination is prepared from the following medicinal materials in parts by weight: 18-22 parts of costustoot, 18-22 parts of immature bitter orange, 18-22 parts of fructus aurantii, 27-33 parts of rhizoma curcumae, 27-33 parts of common burreed rhizome, 18-22 parts of endothelium corneum gigeriae galli, 4.5-5.5 parts of inula flower, 18-22 parts of fructus mume, 18-22 parts of akebia stem and 4.5-5.5 parts of fructus crotonis. The traditional Chinese medicine combination is a scientific composition which is obtained through careful screening and repeated verification according to basic theory of Chinese veterinary science and in combination with the yielded fruitful results of the modern pharmacology study. A large number of clinical trials prove that the traditional Chinese medicine combination has the technical advantages of good curative effect and fast effects on inability to eat or deficiency of food of pigs. In addition, the traditional Chinese medicine combination has the advantages of wide source of raw materials, low cost, simple preparation process and convenience in administration, and has a good marketing prospect. Meanwhile, the traditional Chinese medicine combination is a pure traditional Chinese medicine preparation, is highly safe for animal bodies, and is not likely to generate medicine residue.
Description
Technical field
The invention belongs to veterinary drug technical field, be specifically related to a kind ofly treat the depressed Chinese medicine composition of pig appetite.
Background technology
Depressed, the loss of appetite disorderly with digestive system clinically of pig appetite is even useless absolutely, constipation for principal character, be more common in sow due to farrow, puerperal sow and barren sow.Feeding quality difference or arrange in pairs or groups not science, use improper, the febrile disease of medicine and gastroenteropathy, as digestive tract ulcer, chronic hepatitis, dyspepsia, prolonged constipation etc. all can cause pig appetite depressed.Pig feed intake reduces, and often causes waiting produce sow difficult labour or produce weak piglet; Milking sow lactation power declines, so that piglet nutrition is bad, poor growth becomes cad pig, and resistance declines and Other diseases and dead occurs; Sow recovered bad, became thin puerperal, occurred non-estrus after wean, though or can rutting, Repeat breeding, though indivedual sow can be mixed, litter size is not high, finally causes sow dead or be forced to eliminate; Barren sow occurs that resistance declines or causes the problems such as retardation of growth, and severe patient even causes death.Therefore, inappetence can not be ignored in pig industry.
Depressed for pig appetite, traditional therapy many employings Western medicine preparation, Therapeutic Principle is to promote gastrointestinal peristalsis, anti-inflammation, logical intestinal convenient, medication is that penicillin coordinates the mixing of dipyrone (or aminophenazone) dexamethasone substantially, be aided with acetylcholine and gastrointestinal peristalsis medicine carries out intramuscular injection, therapeutic effect is often not good, and side effect is comparatively large, can not fundamentally cure diseases.The depressed pharmaceutical composition effect of existing treatment pig appetite is imprecise, therefore, seeks green, safety, medicine is imperative efficiently.
Summary of the invention
The object of the invention is to treat the depressed Chinese medicine composition of pig appetite to provide a kind of.
Based on above-mentioned purpose, this invention takes following technical scheme: a kind ofly treat the depressed Chinese medicine composition of pig appetite, with parts by weight, comprising: the Radix Aucklandiae 18 ~ 22 parts, Fructus Aurantii Immaturus 18 ~ 22 parts, Fructus Aurantii 18 ~ 22 parts, Rhizoma Curcumae 27 ~ 33 parts, Rhizoma Sparganii 27 ~ 33 parts, Endothelium Corneum Gigeriae Galli 18 ~ 22 parts, Flos Inulae 4.5 ~ 5.5 parts, Fructus Mume 18 ~ 22 parts, Caulis Akebiae 18 ~ 22 parts, Fructus Crotonis 4.5 ~ 5.5 parts.
Described Chinese medicine composition also comprises Fructus Crataegi 18 ~ 22 weight portion, to improve therapeutic effect further.
Described Chinese medicine composition is powder, wherein Fructus Crotonis making drugs into frostlike powder, and the Fructus Mume vinegar process of preparing Chinese medicine, enucleation, oven dry, together pulverize as end with Fructus Mume after all the other raw material stoving, crosses 60 mesh sieves, adds Semen Crotonis Pulveratum mix homogeneously and get final product.
Described bake out temperature is 60 ~ 65 DEG C.
Chinese veterinarian thinks, pig appetite is depressed many because of the wet tired and gastrointestinal deficiency of body fluid of taste dyspepsia, weakness of the spleen and stomach, incoordination between the spleen and stomach, taste etc., should focus on function of spleen and stomach regulating, regulate the transportation capabilities of taste, facilitating digestion functional rehabilitation is the depressed key for the treatment of pig appetite.
The present invention according to Chinese veterinarian's rationale and in conjunction with the great achievement of modern pharmacology research, through the scientific composition of meticulously screening, obtain after multiple authentication.A large amount of clinical trial proves, Chinese medicine composition provided by the invention is not eaten sow or lacks the technical advantage of the effective in cure height of tableware, instant effect puerperal.In addition, the raw material sources of this Chinese medicine composition are extensive, with low cost, preparation technology simple and dispensing is convenient, have good marketing prospect.Meanwhile, said composition is pure Chinese medicinal preparation, high to animal body safety, and is not easy to produce drug residue.
Specifically, in the present invention, each crude drug has following pharmacological action respectively:
the Radix Aucklandiae:the Radix Aucklandiae is the root of the feverfew Radix Aucklandiae, originates in India, Pakistan, Burma person, is called Radix Aucklandiae (Radix Vladimiriae), and existing China has cultivated successfully; Main product in Yunnan, Guangxi person, be called Saussurea lappa Clarke; Main product claims Radix Vladimiriae in the ground such as Sichuan, Tibet person.This product acrid in the mouth, hardship, warm in nature; Return spleen, stomach, liver, large intestine channel, the pain relieving of energy warming middle-JIAO to promote flow of QI, strengthening the spleen to promote digestion intestinal stasis relieving.These product pungent temperature perfume is loose, can rise and can fall, and leads to the gas of reason three Jiao, especially the gas of benefaction gastrointestinal and pain relieving, and have the merit of strengthening the spleen to promote digestion concurrently, caused by all taste QI stagnation of the large intestine, all cards are conventional product.The traditional Chinese medical science has emphasized that gastric qi person is raw, and extreme hypofunction of the stomach person is dead, and every patient obtaining intractable apositia just belongs in the traditional Chinese medical science and says: " extreme hypofunction of the stomach person is dead ".The Radix Aucklandiae can make body produce hunger sensation (hypothalamic physiological reaction) and have no side effect, and is principal agent in the present invention.
Modern study shows, containing volatile oil and saussurine etc. in the Radix Aucklandiae, has the effect such as two-ways regulation gastrointestinal tract, the secretion of facilitating digestion liquid, antiulcer, function of gallbladder promoting, lax tracheal smooth muscle, bacteriostasis antibiosis, diuresis, promotion fibrinolysis.
fructus Aurantii Immaturus:bitter in the mouth, pungent, sour, warm in nature.Return spleen, stomach warp.Kind dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm, can be used for stagnant in stop, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest, gastroptosis, proctoptosis, the cards such as uterine prolapse.
Fructus Aurantii Immaturus is the dry young fruit of rutaceae Citrus aurantium Linn. and variety or Fructus Citri sinensis, main product in Sichuan, Jiangxi, Fujian, the ground such as Jiangsu.Sour orange peel is containing volatile oil, flavonoid glycoside (being mainly Hesperidin, neohesperidin, naringin, Radix seu Folium Tosicodendri Delavayi glucoside and xylostein etc.), N-methyltyramine, oxedrine, norepinephrine, tryptamines promise woods etc.In addition, still fatty, protein, carbohydrate, carotene, riboflavin, calcium, phosphorus, ferrum etc.
Research shows, Fructus Aurantii Immaturus has following pharmacological action:
(1) the effect Furctus Aurantii Immaturus extract of cardiovascular system, Fructus Aurantii Immaturus injection and effective ingredient oxedrine (Xin Fulin) thereof and N-methyltyramine are had to heart tonifying, increase cardiac output, vasoconstrictive, raising total peripheral resistance, and make the effect that left ventricular pressure and arteriotony rise.Fructus Aurantii Immaturus and Fructus Aurantii decoct, to Isolated Toad Heart, make it shrink enhancing during low concentration; During high concentration, asystole .N-methyltyramine also can strengthen contractility that is in vitro and heart in vivo.
(2) all inhibitory action is had to the intestine in vitro of mice, rabbit and rabbit at body intestinal tube to the water decoction of the effect Fructus Aurantii Immaturus of gastrointestinal, Fructus Aurantii, tincture and fluid extract.It is strong that decocting liquid makes stomach, the gastrointestinal of intestinal fistula Canis familiaris L. shrinks the rhythm and pace of moving things, in excitation, but suppresses Canis familiaris L. at body gastrointestinal motility.Furctus Aurantii Immaturus extract has obvious antagonism to intestinal contraction caused by acetylcholine and histamine.
(3) to the effect Fructus Aurantii Immaturus in uterus and Fructus Aurantii decoct to mice isolated uterine, no matter pregnant or unpregnancy, mainly in inhibitory action; In vitro or the Uterus in vivo to rabbit, no matter pregnant or unpregnancy, all in excitation; Also have significant excitation to fistula of uterus, uterine contraction can be made strong, and tonicity is strengthened, and even occurs tetanic contraction. and Fructus Aurantii Immaturus hot water extract shrinks the Isolated Rat Uterus that 5-hydroxy tryptamine causes and has antagonism.
(4) there is obvious sedation to the effect Furctus Aurantii Immaturus extract of nervus centralis, mice peace and quiet can be made few dynamic; Without syngignoscism, but there is synergism with pentobarbital hypnosis; The pain reaction that Furctus Aurantii Immaturus extract can make mice cause because of acetic acid alleviates; The body temperature rising that rabbit is caused by Typhoid Vaccine can be reduced; Also have report to point out, (R)-4-isopropenyl-1-methyl-1-cyclohexene has central inhibitory action.
(5) diuresis Fructus Aurantii Immaturus and N-methyltyramine are all significantly increased the effect of urine volume to dog intravenous injection, and blood pressure and renal vascular resistance obviously increase simultaneously.This diuresis may be produce by suppressing other effects such as reabsorption, has nothing to do with the change of renal blood flow and kidney filtrable volume.Also have report to think, Fructus Aurantii Immaturus by heart tonifying, shrink Renal vascular, increase filtration pressure and play natriuretic diuretic effect.
(6) other Effect study show, the neohesperidin in Fructus Aurantii Immaturus, naringin have anti-inflammatory effect, have with the paeoniflorin in Radix Paeoniae the effect be multiplied.
fructus Aurantii:bitter, pungent, sour, temperature.Return spleen, stomach warp.Dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.
Various Fructus Aurantii is all containing the material such as volatile oil and flavonoid glycoside. containing neohesperidin in the peel of Citrus aurantium L. var. amara Engl. immature fruit; During fruit maturation, neohesperidin disappears and naringin increases. connect in maturescent Citrus aurantium Linn. fruit containing vitamin C.From perfume (or spice) circle with Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) be separated to obtain same alkaloid sample material.
rhizoma Curcumae:pungent, bitter, temperature, returns liver, spleen channel, can removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, and note of the ancient Chinese abdominal mass that can be used for caused by energy stagnation and blood stasis is gathered and trusted subordinate's stasis of blood pain etc.; Or in food stagnation abdominal distention.
Containing a large amount of volatile oil composition in Rhizoma Curcumae, wherein RADIX CURCUMAE contains australene, nopinene, Camphora, 1,8-eudesmol, Borneolum Syntheticum, curcumenol, isocurcumenol etc.Guangxi zedoary contains australene, nopinene, limonene, Borneolum Syntheticum, Camphora, eugenol, zingiberene, curcumenol, curzerenone, fragrant zingiberone, turmerone, anhydrocurcolone etc.Rhizoma Curcumae volatile oil preparation, to the existing direct destruction of multiple cancerous cell, makes specific immunity strengthen by immune system again and obtains obvious immunoprotective effec, thus having antitumaous effect.Curcuma wenyujin volatile oil can suppress the growth of various pathogens; 1% Oleum Curcumae has inhibitory action to animal acetic acid peritonitis, has inhibitory action to mice local edema, inflammation.Oleum Curcumae has obvious anti-ulcer effect.Aqueous extracts can anticoagulant, promotes arteriole restoration of blood flow, stops arteriole to shrink completely, obviously promotes that local microcirculation is recovered; Rhizoma Curcumae water extracting alcohol liquid is formed with inhibitory action to thrombus in vivo.In addition Rhizoma Curcumae has direct deactivation to respiratory syncytial virus, and Oleum Curcumae has and significantly protects the liver and antiearly pregnancy effect.
rhizoma Sparganii:pungent, bitter, flat.Return liver, spleen channel.Kind removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, for diseases such as lump in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pains.
Rhizoma Sparganii contains volatile oil, and in oil, main component is phenethanol, hydroquinone, hexadecylic acid, removes stem constuslactone etc. and multiple organic acid.Rhizoma Sparganii water extract energy significant prolongation thrombin is to the pool time of human fibrin; Water decoction energy significantly anticoagulant, reduces whole blood viscosity; Obviously can extend thrombin time of blood plasma and kaolin part clotting time; The anti-ex vivo thrombosis of energy, and make thrombosis time lengthening, thrombosis contraction in length, thrombus weight alleviates, and can make euglobulin time shorten.Water decoction has excitation to isolated rabbit uterus.
endothelium Corneum Gigeriae Galli:sweet, cold.Return spleen, stomach, small intestinal, urinary bladder channel, there is effect of promoting digestion and invigorating the stomach, arresting seminal emission.
Containing gastric hormone, keratin, micro-pepsin, amylase, multivitamin and trace element in Endothelium Corneum Gigeriae Galli, and 18 seed amino acids etc.After oral Endothelium Corneum Gigeriae Galli powder, gastric secretion, acidity and eupepsy are all shown in raising, and gastric motor function obviously strengthens; Experiment in vitro can strengthen pepsin, pancreatic lipase activity.
flos Inulae:bitter in the mouth, pungent, salty, warm in nature.Enter lung, liver, stomach warp.Energy expectorant, Hang Shui, sending down the abnormal ascending QI, preventing or arresting vomiting, softening the hard mass, cure mainly expectorant in the heart and tie, coerce lower distension, cough with asthma, singultus, saliva as shellac varnish, epigastric oppression and rigidity, eructation unrelieved, extensive abdominal edema.
The aerial parts of inula Britannica flowering period contains the multiple sterols such as Quercetin (Quercetin), isoquercitin (Isoquercetin), caffeic acid (Caffeic acid), chlorogenic acid (Chlorogenic acid), inulin and taraxasterol (Taraxasterol) containing sesquiterpene lactones compound Brevicornin Britanin (Britanin) and inulin (Inulicin), flower.It has following pharmacological action:
(1) relieving asthma, antitussive effect inula flavonoid has significant protective effect to the guinea pig bronchial spasmodic asthma that histamine causes; Also antagonism is had to the guinea-pig isolated trachea spasm that histamine causes, but slow and weak compared with the effect of aminophylline.Mice ammonia spraying method and the experiment of PSP method show: inula flavonoid is without antitussive and phlegm-dispelling functions, and every mouse peritoneal injects 150% Flos Inulae decoct 0.1ml, within latter 1 hour, have remarkable antitussive effect, but expectorant effect is not obvious in injection.
(2) the fat-soluble and ether insoluble portion that the root of antibacterial action inula Britannica and overground part divide has antibacterial action.Caffeic acid in Flos Inulae and chlorogenic acid have bacteriostasis more widely, but in vivo can by protein deactivation.Dull and stereotyped paper disk method or trench method test show: Flos Inulae decoct (1:1) has obvious inhibitory action to staphylococcus aureus, anthrax bacillus and shigella flexneri II a strain, but the more weak or unrestraint effect to the effect of the various pathogens such as Hemolytic streptococcus, escherichia coli, Bacillus typhi, bacillus pyocyaneus, Bacillus proteus, diphtheria corynebacterium.
(3) small intestinal peristalsis of rat, mice significantly can be increased to the effect chlorogenic acid of smooth muscle; Chlorogenic acid, caffeic acid, quininic acid all can increase the tension force in uterus, but this effect can cancel by papaverine, atropine then has no significant effect this.
(4) to the effect chlorogenic acid of central nervous system and caffeic acid to Oral Administration in Rats or lumbar injection, all can improve the nerve excitability of rat.
(5) to the effect chlorogenic acid of digestive system and caffeic acid oral, the secretory volume of hydrochloric acid in people's stomach can be increased; Also the effect increasing rat bile secretion is had.
(6) other effect zooperies show: in isolated rabbit ileum specimen, chlorogenic acid can strengthen adrenergic effect; But on the effect of epinephrine raise blood sugar, prevention rat Ovum Gallus domesticus album ankle edema then without impact.
fructus Mume:sour in the mouth, property is put down nontoxic, returns liver, spleen, lung large intestine channel, tool astringe the lung promote the production of body fluid, the merit of astringing intestine to stop diarrhea relieving colic caused by ascaris.
Fructus Mume is containing citric acid 19%, malic acid 15%, succinic acid, carbohydrate, sitosterol, ceroidlike material and oleanolic acid sample material.At mature period containing hydrocyanic acid.The Fructus Mume processed from strand is dry containing citric acid 50%, malic acid 20%, also contains strong bactericidal properties and improves the composition picric acid of liver function and have the almond glycoside of hot analgesic activity.Superoxide dismutase (SOD) still containing greater activity in Fructus Mume sarcocarp.Fresh Fructus Mume fruit is containing pectin.Fructus Mume seed is containing amygdalin. and water decocted solution of fructus mume (1:1) all has inhibitory action to anthrax bacillus, diphtheria and diphtheroid, bacillus subtilis, staphylococcus (golden yellow, lemon yellow, white), streptococcus pneumoniae, also effective to enteral pathogenic bacterium such as escherichia coli, bacterium sonnei, Bacillus proteus, Typhoid and paratyphoid bacillus, bacillus pyocyaneus, vibrio cholera, and to first or second kind streptococcus without effect.Fructus Mume soup has promotion to shrink and choleretic effect to gallbladder, is beneficial to the bile of drain biliary tract, reduces and prevents biliary tract infection.Fructus Mume has increase appetite, facilitating digestion, the effect of saliva stimulating gland, gastric gland secrete digestive juices; Also there is significant whole intestinal effect, promote enterokinesia, diminish inflammation; There is again the effect of shrinking intestinal wall simultaneously, thus may be used for treatment diarrhoea.
caulis Akebiae:bitter in the mouth, cool in nature, GUIXIN, lung, small intestinal, urinary bladder channel, tool clearing away heat and promoting diuresis, the merit of stimulating milk secretion of stimulating the menstrual flow.
Caulis Akebiae is containing akebin (Akebin), and akebin is hydrolyzed to obtain hederagenin, oleanolic acid, glucose and rhamnose; Still containing potassium salt 0.254%.Caulis Aristolochiae Manshuriensis is containing Aristolochic Acid (Aristolochic acid), hederagenin (Hederagenin), oleanolic acid (Oleanolic acid) etc.
The effect of Caulis Akebiae:
(1) to the effect of cardiovascular system: Caulis Aristolochiae Manshuriensis decoct (0.5 ~ 2g/kg), to anesthetized rabbit and dog intravenous injection, can make its blood pressure rise immediately, then decline, phenomenon is reduced in long-term Secondary cases blood pressure.Indivedual rabbit then only has blood pressure to reduce.The heart of Caulis Aristolochiae Manshuriensis decoct to Isolated Toad, Cavia porcellus has similar digitaloid effect, and research proves that this effect is caused by wherein contained calcium and tannic acid.
(2) to the effect of smooth muscle: Caulis Aristolochiae Manshuriensis decoct has excitation to isolated mouse small intestinal, inhibitory action is had to isolated mouse unpregnancy and pregnant uterus.Aristolochic Acid has contraction to rabbit in the body uterus of body and intestine in vitro.
(3) diuresis: experiment proves, Caulis Akebiae has obvious diuresis.Caulis Akebiae tincture is oral to rabbit, to rabbit, oral or intravenous injection has significant diuresis to Caulis Akebiae decoct.
fructus Crotonis:acrid in the mouth, hot in nature, very toxic.Enter stomach, large intestine, lung meridian.Cold long-pending, orifice opening can be rushed down, by expectorant, Hang Shui, parasite killing, cure mainly coldly long-pendingly to stagnate, distension and fullness of the chest and abdomen shoot, abdominal mass due to blood stasis, accumulation of phlegm in the hypochondrium, dysentery, edema, external control acute throat trouble, sore throat, malignant boil scabies, nevus verrucosus etc.
Containing Oleum Tiglii, Fructus Crotonis-12,13-diester, crotonyl alcohol. three ester in Fructus Crotonis seed, also claim crotin containing a kind of toxicity globulin, containing stronger zest simultaneously.Making drugs into frostlike powder process can reduce the oil content of Fructus Crotonis, and makes crotin inactivation, reduces zest.
fructus Crataegi: sour, sweet, tepor.Return spleen, stomach, Liver Channel.There is effect of promoting digestion and removing stagnation, promoting blood circulation to remove blood stasis.Containing chlorogenic acid (chlorogenic acid), caffeic acid, Crataegolic acid (crataegolic acid), neat chrysanthemum fruit acid, Quercetin, ursolic acid, oleanolic acid, hyperin (hyperin), epicatechin (epicatechin) etc. in Fructus Crataegi.
The main component of Fructus Crataegi is Flavonoid substances, has obvious pharmacological action to cardiovascular system.At present, the flavone component be separated from Fructus Crataegi has more than 30 to plant, and mainly contains containing the flavonoid glycoside of carbon bond, flavonol and glycoside thereof, dioxygen flavonoid glycoside, polymerization flavonoid.The composition of another kind of outbalance is triterpene substance, has heart tonifying, increases coronary blood flow, improves the important function such as blood circulation.In addition, organic acid is contained in Fructus Crataegi as chlorogenic acid, caffeic acid and tannin, acid anhydride of tanning, epicatechol, choline, acetylcholine, Sitosterolum, carotene and a large amount of Vit C etc.
The effect of Fructus Crataegi:
(1) anti-cancer, anticancer research in recent years find, containing a kind of compound being vitexin in Fructus Crataegi, to have anticancer effect.Nitrosamine, flavacin all can be brought out the generation of alimentary tract cancer or be increased the weight of, and experimentation shows, hawthorn extract can not only the synthesis of blocking nitrosamine formation, also can suppress the carcinogenesis of flavacin.So the high-risk group of alimentary tract cancer should frequent edible haw, for the patient suffering from cancer, if also can cook congee edible together with Fructus Crataegi, rice when there is dyspepsia, so both can be aid digestion, the effect of anticancer adjuvant can be played again.
(2) heart tonifying, blood fat reducing, blood pressure lowering clinical research confirmation, Fructus Crataegi can significantly reduce serum cholesterol and triglyceride, effectively prevents and treats atherosclerosis; Fructus Crataegi also plays heart tonifying by strengthening myocardial contraction, increase cardiac output, coronary artery dilator blood vessel, increase coronary flow, reduction myocardial oxygen consumption etc. and prevents anginal effect.In addition, the total flavones in Fructus Crataegi has the effect of blood vessel dilating and lasting blood pressure lowering.Therefore, hyperlipidemia, hypertension and patients with coronary heart disease, every day desirable Fructus Crataegi 15 ~ 30 grams, decocting is for tea-drinking.
(3) treat dysmenorrhea, the menoxenia traditional Chinese medical science thinks that Fructus Crataegi has the effect of activating blood circulation to dissipate blood stasis, is the dietetic therapy good merchantable brand of blood stasis type dysmenorrhea patient.Blood stasis type dysmenorrhea patient often shows as to pass through and lower abdomen pain occurred in 1st ~ 2 days or premenstrual 1 ~ 2 day, and when menses are discharged smooth, pain alleviates gradually or disappears, and menses darker in color, with clot.The desirable complete band core fresh Fructus Crataegi 1000 grams of patient, adds suitable quantity of water after cleaning, and slow fire infusion is known something thoroughly to Fructus Crataegi, adds 250 grams, brown sugar, then infusion 10 minutes, treats that it becomes scattered paste shape.Premenstrual 3 ~ 5 days start to take, and every day is each food hawthorn 30 milliliters sooner or later, until through after within 3 days, cut out, this is 1 course for the treatment of, and serveing on 3 courses for the treatment of can take effect.This method is also applicable to menoxenia, Chinese medical discrimination is blood stasis person.
In prescription provided by the invention, the pain relieving of Radix Aucklandiae energy warming middle-JIAO to promote flow of QI, strengthening the spleen to promote digestion intestinal stasis relieving are monarch drug.The merit of Fructus Aurantii Immaturus, Fructus Aurantii equal tool dispelling the stagnated QI removing food stagnancy, Fructus Aurantii Immaturus is kind help digestion long-pending, Fructus Aurantii is kind cool down long-pending; Rhizoma Curcumae is apt to the gas in treating blood disorders, Rhizoma Sparganii is kind regulate the flow of vital energy in blood, this four taste is ministerial drug.Endothelium Corneum Gigeriae Galli, Fructus Crataegi all have effect that promoting digestion and invigorating the stomach, dyspepsia are not changed, Flos Inulae stopping nausea and vomiting by lowering the adverse flow of QI, and Fructus Crotonis cures mainly distension and fullness of the chest and abdomen, are adjuvant drug.Vinegar can whet the appetite, promote to help digest the secretion of saliva and gastric juice absorption, make honey stomach, promoting digestion and removing stagnation; Concoct Fructus Mume with vinegar, can strengthen effect of Fructus Mume, Caulis Akebiae is stimulated the menstrual flow the heat of stimulating milk secretion, the small intestinal that drops, and jointly plays the effect making medicine.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be further described.
embodiment 1
A kind ofly treat the depressed Chinese medicine composition of pig appetite, with parts by weight, comprising: the Radix Aucklandiae 20 parts, Fructus Aurantii Immaturus 20 parts, Fructus Aurantii 22 parts, Rhizoma Curcumae 30 parts, Rhizoma Sparganii 30 parts, Endothelium Corneum Gigeriae Galli 20 parts, Flos Inulae 5 parts, Fructus Crataegi 20 parts, Fructus Mume 20 parts, Caulis Akebiae 20 parts, Fructus Crotonis 4.5 parts.
In top, Fructus Crotonis making drugs into frostlike powder, the Fructus Mume vinegar process of preparing Chinese medicine, enucleation, oven dry, together pulverize as end with Fructus Mume after all the other raw material stoving, crosses 60 mesh sieves, add Semen Crotonis Pulveratum mix homogeneously and get final product.Bake out temperature is 60 DEG C
embodiment 2
A kind ofly treat the depressed Chinese medicine composition of pig appetite, with parts by weight, comprising: the Radix Aucklandiae 18 parts, Fructus Aurantii Immaturus 18 parts, Fructus Aurantii 20 parts, Rhizoma Curcumae 33 parts, Rhizoma Sparganii 27 parts, Endothelium Corneum Gigeriae Galli 18 parts, Flos Inulae 4.5 parts, Fructus Crataegi 22 parts, Fructus Mume 18 parts, Caulis Akebiae 22 parts, Fructus Crotonis 5.5 parts.
In top, Fructus Crotonis making drugs into frostlike powder, the Fructus Mume vinegar process of preparing Chinese medicine, enucleation, oven dry, together pulverize as end with Fructus Mume after all the other raw material stoving, crosses 60 mesh sieves, add Semen Crotonis Pulveratum mix homogeneously and get final product.Bake out temperature is 65 DEG C
embodiment 3
A kind ofly treat the depressed Chinese medicine composition of pig appetite, with parts by weight, comprising: the Radix Aucklandiae 22 parts, Fructus Aurantii Immaturus 22 parts, Fructus Aurantii 18 parts, Rhizoma Curcumae 27 parts, Rhizoma Sparganii 33 parts, Endothelium Corneum Gigeriae Galli 22 parts, Flos Inulae 5.5 parts, Fructus Crataegi 18 parts, Fructus Mume 18 parts, Caulis Akebiae 18 parts, Fructus Crotonis 5 parts.
In top, Fructus Crotonis making drugs into frostlike powder, the Fructus Mume vinegar process of preparing Chinese medicine, enucleation, oven dry, together pulverize as end with Fructus Mume after all the other raw material stoving, crosses 60 mesh sieves, add Semen Crotonis Pulveratum mix homogeneously and get final product.Bake out temperature is 62 DEG C
embodiment 4
Treat the Chinese medicine composition that pig appetite is depressed, with parts by weight, comprising: the Radix Aucklandiae 20 parts, Fructus Aurantii Immaturus 18 parts, Fructus Aurantii 19 parts, Rhizoma Curcumae 28 parts, Rhizoma Sparganii 30 parts, Endothelium Corneum Gigeriae Galli 20 parts, Flos Inulae 5 parts, Fructus Mume 22 parts, Caulis Akebiae 21 parts, Fructus Crotonis 5 parts.
In top, Fructus Crotonis making drugs into frostlike powder, the Fructus Mume vinegar process of preparing Chinese medicine, enucleation, oven dry, together pulverize as end with Fructus Mume after all the other raw material stoving, crosses 60 mesh sieves, add Semen Crotonis Pulveratum mix homogeneously and get final product.Bake out temperature is 60 DEG C
embodiment 5 effect test
Apply Chinese medicine composition of the present invention and carry out clinical practice experiment on 15 pig farms to amounting to 408 pigs, in these pigs, some is not eaten at the inappetence occurring to occur after other diseases or low temperature, have plenty of sow to occur inappetence puerperal, even do not eat, another part is then directly occurred that low temperature is not eaten or eats symptom less, and the rear weak effect of other drug treatment on probation, mortality rate are high.
(1) experimental program: to stop using other drug to there is inappetence or the sick pig that do not eat in morbidity pig farm, apply Chinese medicine composition of the present invention, continuous use 6 ~ 10 days, coordinate simultaneously and improve feeding and management condition, strengthen sterilization, and in drinking-water, add 0.5% glucose, 0.1% electrolysis multidimensional, 0.1% oresol, to strengthen resistivity.Period observes disease hog condition, Estimating curative effect.
(2) Outcome measure:
Recovery from illness: use sick pig in Chinese medicine composition of the present invention 10 days to recover dysregulated appetite and the mental status.
Effective: to use Chinese medicine composition of the present invention 10 days, sick pig recovers appetite 70%, and spirit is normal.
Take a turn for the better: use Chinese medicine composition of the present invention 10 days, aphagia shape is alleviated to some extent, and spirit is slightly poor.
Invalid: use this medicine 10 days continuously, symptom loses improvement.
(3) experimental result: to the application of 408 ill pigs Chinese medicine composition of the present invention, that wherein cures completely has 133,201 of Be very effective, 36 of improvement, invalid 38.It can thus be appreciated that utilize the low temperature aphagia of traditional Chinese medicine composition for treating pig of the present invention, effective percentage reaches 91%, evident in efficacy.
Here is the specific experiment situation on wherein several pig farm:
experiment 1:zhongmou County large-scale pig farm, live pig livestock on hand 10000.Winter in 2011, temperature declines suddenly, and inappetence has appearred in part growing and fattening pigs, even the low temperature symptom of not eating, and application other drug therapeutic effect is poor, and sick pig consumes very fast, and mortality rate is high, causes larger economic loss.After will to fall ill pig 21 isolated rearings, according to the Chinese medicine composition administration of embodiment 1, every 100kg body weight administration 30g, gavages or directly mixes a small amount of concentrate twice on the one and feed.3rd day, most sick pig started to search for food, and spirit takes a turn for the better; Continue to feed said composition to the 6th day, swinery recovers normal completely.
experiment 2:kaifeng large―scale hoggery, 35 age in days left and right piglets are suffered from diarrhoea, and after healing, about 50 piglets do not eat, and then treat with the Chinese medicine composition of embodiment 4, every piglet medication 5 ~ 10g, and twice on the one water punching gavages.Strengthen feeding and management simultaneously, improve colony house temperature, and in drinking-water, add 0.5% glucose, 0.1% electrolysis multidimensional, 0.1% oresol, to strengthen resistivity.After said composition of feeding the 2nd day, most of piglet started to search for food, and spirit takes a turn for the better to some extent, continues to feed 3 days, does not eat disease and is almost recovered, and sick pig recovers normal.
experiment 3:linzhou City's large-scale pig farm, summer in 2012, heat, fattening house part growing and fattening pigs (about 80kg) appearance does not suddenly eat disease.Being found by field investigation afterwards, may be that temperature is higher, the disorder of the digestive function of pig caused.Select inappetence, disease of not eating food pig 80, then treat with the Chinese medicine composition of embodiment 2, every pig medication 40g, twice on the one water punching gavages or directly mixes a small amount of concentrate and feed.Strengthen feeding and management simultaneously, reduce colony house temperature.From feeding Chinese medicine composition of the present invention 4th day, aphagia takes a turn for the better greatly, and the pig appetite of 50% recovers normal, the mental status is good, the sick pig do not recovered completely, continues medication 4 days, swinery recovers normal substantially, and eliminate the pig that part is seriously ill, therapeutic effect is bad, pig farm returns to normal production.
experiment 4:in December, 2012, the 4 tire sows that Zhongmou County port owned by the government town Lee raises do not eat puerperal always.Clinical symptoms shows as lassitude, crouches on the ground, drives and be reluctant to walk about, body temperature 38.6 DEG C, and defecation is dry in spherical, and mouth color, conjunctiva color are light pure, and after three days, milk amount falls sharply, and are diagnosed as aphagia in puerperal.Treat with the Chinese medicine composition of embodiment 4 immediately, every 100kg body weight administration 25 ~ 30g, one day twice, water punching gavages or mixes a small amount of concentrate and feeds.3rd day, this pig started to search for food, and spirit takes a turn for the better to some extent, continuation medication 3 days, and appetite, spirit are recovered normally completely, breast amount increases.
experiment 5:in July, 2013,2 sows that department of Xing Zhuan township, Weizhi County, Kaifeng raises occur that puerperal does not eat phenomenon.Wherein a body weight is about 148kg, in farrowing on July 9 14; A body weight is about 220kg, in farrowing on July 5 16.Two sow occurred not eating phenomenon about 3 days puerperal respectively, and local veterinary has no improvement in 3 days with benzylpenicillin potassium, 30% dipyrone, dexamethasone in treatment, and still less effective when, escalated dose constant in said medicine.Get rid of the prerequisite of highly pathogenic PRRS in laboratory diagnosis under, treat immediately with the Chinese medicine composition of embodiment 3, every sow is according to the dose administration of every 100kg body weight 25 ~ 30g, and water rushes and gavages or mix a small amount of concentrate and feed.Treat symptom after 4 days to alleviate to some extent, appetite increases to some extent, and energy normal lactation, be used in conjunction again 4 days, each head sow appetite recovers normal completely, and the mental status is good.Do not have a rebound by return visit.
Claims (4)
1. treat the depressed Chinese medicine composition of pig appetite for one kind, with parts by weight, comprising: the Radix Aucklandiae 18 ~ 22 parts, Fructus Aurantii Immaturus 18 ~ 22 parts, Fructus Aurantii 18 ~ 22 parts, Rhizoma Curcumae 27 ~ 33 parts, Rhizoma Sparganii 27 ~ 33 parts, Endothelium Corneum Gigeriae Galli 18 ~ 22 parts, Flos Inulae 4.5 ~ 5.5 parts, Fructus Mume 18 ~ 22 parts, Caulis Akebiae 18 ~ 22 parts, Fructus Crotonis 4.5 ~ 5.5 parts.
2. the Chinese medicine composition that treatment pig appetite as claimed in claim 1 is depressed, it is characterized in that, described Chinese medicine composition also comprises Fructus Crataegi 18 ~ 22 weight portion.
3. the Chinese medicine composition that treatment pig appetite as claimed in claim 1 or 2 is depressed, it is characterized in that, described Chinese medicine composition is powder, wherein Fructus Crotonis making drugs into frostlike powder, the Fructus Mume vinegar process of preparing Chinese medicine, enucleation, oven dry, together pulverize as end with Fructus Mume after all the other raw material stoving, cross 60 mesh sieves, add Semen Crotonis Pulveratum mix homogeneously and get final product.
4. the Chinese medicine composition that treatment pig appetite as claimed in claim 3 is depressed, it is characterized in that, described bake out temperature is 60 ~ 65 DEG C.
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