CN103566312A - Traditional Chinese medicine combination for treating loss of appetite of pigs - Google Patents
Traditional Chinese medicine combination for treating loss of appetite of pigs Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine combination for treating the loss of appetite of pigs and belongs to the technical field of veterinary medicines. The traditional Chinese medicine combination is prepared from the following medicinal materials in parts by weight: 18-22 parts of costustoot, 18-22 parts of immature bitter orange, 18-22 parts of fructus aurantii, 27-33 parts of rhizoma curcumae, 27-33 parts of common burreed rhizome, 18-22 parts of endothelium corneum gigeriae galli, 4.5-5.5 parts of inula flower, 18-22 parts of fructus mume, 18-22 parts of akebia stem and 4.5-5.5 parts of fructus crotonis. The traditional Chinese medicine combination is a scientific composition which is obtained through careful screening and repeated verification according to basic theory of Chinese veterinary science and in combination with the yielded fruitful results of the modern pharmacology study. A large number of clinical trials prove that the traditional Chinese medicine combination has the technical advantages of good curative effect and fast effects on inability to eat or deficiency of food of pigs. In addition, the traditional Chinese medicine combination has the advantages of wide source of raw materials, low cost, simple preparation process and convenience in administration, and has a good marketing prospect. Meanwhile, the traditional Chinese medicine combination is a pure traditional Chinese medicine preparation, is highly safe for animal bodies, and is not likely to generate medicine residue.
Description
Technical field
The invention belongs to veterinary drug technical field, be specifically related to a kind of depressed Chinese medicine composition of pig appetite for the treatment of.
Background technology
Pig appetite is depressed take that digestive system is disorderly, loss of appetite is even useless absolutely, constipation is principal character clinically, is more common in sow due to farrow, puerperal sow and barren sow.Poor or the science of arranging in pairs or groups not of feeding quality, use that medicine is improper, febrile disease and gastroenteropathy, as digestive tract ulcer, chronic hepatitis, dyspepsia, prolonged constipation etc. all can cause that pig appetite is depressed.Pig feed intake reduces, and tends to cause sow difficult labour to be produced or produces weak piglet; Milking sow lactation power declines, so that piglet malnutrition, poor growth become cad pig, and resistance declines and Other diseases occurs and death; Sow recovered bad, became thin puerperal, occurred non-estrus after wean, though or can rutting, Repeat breeding, though indivedual sow can be mixed, litter size is not high, finally causes sow dead or be forced to eliminate; Barren sow occurs that resistance declines or causes the problems such as retardation of growth, and severe patient even causes death.Therefore, inappetence can not be ignored in pig industry.
Depressed for pig appetite, traditional therapy adopts Western medicine preparation more, Therapeutic Principle be take and promoted gastrointestinal peristalsis, anti-inflammation, logical intestinal convenient as main, medication is that penicillin coordinates dipyrone (or aminophenazone) dexamethasone to mix substantially, be aided with acetylcholine and gastrointestinal peristalsis medicine carries out intramuscular injection, therapeutic effect is often not good, and side effect is larger, fundamentally cure diseases.The depressed pharmaceutical composition effect of existing treatment pig appetite is imprecise, therefore, seeks green, safety, medicine is imperative efficiently.
Summary of the invention
The object of the invention is for a kind of depressed Chinese medicine composition of pig appetite for the treatment of is provided.
Based on above-mentioned purpose, the present invention has taked following technical scheme: a kind of depressed Chinese medicine composition of pig appetite for the treatment of, in weight portion, comprising: 18～22 parts of the Radix Aucklandiae, 18～22 parts of Fructus Aurantii Immaturuss, 18～22 parts of Fructus Aurantiis, 27～33 parts of Rhizoma Curcumae, 27～33 parts of Rhizoma Sparganii, 18～22 parts of Endothelium Corneum Gigeriae Galli, 4.5～5.5 parts of Flos Inulaes, 18～22 parts of Fructus Mumes, 18～22 parts of Caulis Akebiaes, 4.5～5.5 parts of Fructus Crotonis.
Described Chinese medicine composition also comprises Fructus Crataegi 18～22 weight portions, further to improve therapeutic effect.
Described Chinese medicine composition is powder, wherein Fructus Crotonis making drugs into frostlike powder, and the vinegar process of preparing Chinese medicine for Fructus Mume, enucleation, oven dry, together pulverize as end with Fructus Mume after all the other raw material stoving, crosses 60 mesh sieves, adds Semen Crotonis Pulveratum mix homogeneously and get final product.
Described bake out temperature is 60 ~ 65 ℃.
Chinese veterinarian thinks, pig appetite is depressed many because of the wet tired and gastrointestinal deficiency of body fluid of taste dyspepsia, weakness of the spleen and stomach, incoordination between the spleen and stomach, taste etc., should focus on function of spleen and stomach regulating, and transportation capabilities, the facilitating digestion functional rehabilitation that regulates taste is the depressed key for the treatment of pig appetite.
The present invention is according to Chinese veterinarian's rationale and in conjunction with the great achievement of modern pharmacology research, the scientific composition obtaining after meticulous screening, multiple authentication.Clinical trials prove in a large number, and Chinese medicine composition provided by the invention does not eat or lack the technical advantage of the effective in cure height of tableware, instant effect puerperal to sow.In addition, the raw material sources of this Chinese medicine composition are extensive, with low cost, preparation technology simple and dispensing is convenient, have good marketing prospect.Meanwhile, said composition is pure Chinese medicinal preparation, safe to animal body, and is not easy to produce drug residue.
Particularly, in the present invention, each crude drug has respectively following pharmacological action:
the Radix Aucklandiae:the Radix Aucklandiae is the root of the feverfew Radix Aucklandiae, originates in India, Pakistan, Burma person, is called Radix Aucklandiae (Radix Vladimiriae) ，Xian China and has cultivated successfully; Main product in Yunnan, Guangxi person, be called Saussurea lappa Clarke; Main product claims Radix Vladimiriae in ground persons such as Sichuan, Tibet.This product acrid in the mouth, hardship, warm in nature; Return spleen, stomach, liver, large intestine channel, the pain relieving of energy warming middle-JIAO to promote flow of QI, strengthening the spleen to promote digestion intestinal stasis relieving.The pungent temperature of these product is fragrant loose, can rise and can fall, and leads to the gas of managing three warmers, and the especially gas of benefaction gastrointestinal and pain relieving has the merit of strengthening the spleen to promote digestion concurrently, and all cards are conventional product due to all taste QI stagnation of the large intestine.The traditional Chinese medical science has emphasized that gastric qi person is raw, and extreme hypofunction of the stomach person is dead, and every patient who obtained intractable apositia just belongs in the traditional Chinese medical science and says: " extreme hypofunction of the stomach person is dead ".The Radix Aucklandiae can make body produce hunger sensation (hypothalamic physiological reaction) and have no side effect, and is principal agent in the present invention.
Modern study shows, contains volatile oil and saussurine etc. in the Radix Aucklandiae, has the effects such as two-ways regulation gastrointestinal tract, the secretion of facilitating digestion liquid, antiulcer, function of gallbladder promoting, lax tracheal smooth muscle, bacteriostasis antibiosis, diuresis, promotion fibrinolysis.
fructus Aurantii Immaturus:bitter in the mouth, pungent, sour, warm in nature.Return spleen, stomach warp.Kind dispelling the stagnated QI removing food stagnancy, the loose painful abdominal mass of reducing phlegm, stops in can be used for stagnating, and feeling of fullness distending pain is heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest, gastroptosis, proctoptosis, the cards such as uterine prolapse.
Fructus Aurantii Immaturus is the dry young fruit of rutaceae Citrus aurantium Linn. and variety or Fructus Citri sinensis, main product in Sichuan, the ground such as Jiangxi, Fujian, Jiangsu.Sour orange peel is containing volatile oil, flavonoid glycoside (being mainly Hesperidin, neohesperidin, naringin, Radix seu Folium Tosicodendri Delavayi glucoside and xylostein etc.), N-methyltyramine, oxedrine, norepinephrine, tryptamines promise woods etc.In addition, still fatty, protein, carbohydrate, carotene, riboflavin, calcium, phosphorus, ferrum etc.
Research shows, Fructus Aurantii Immaturus has following pharmacological action:
(1) the effect Furctus Aurantii Immaturus extract of cardiovascular system, Fructus Aurantii Immaturus injection and effective ingredient oxedrine (Xin Fulin) thereof and N-methyltyramine there are is heart tonifying, increase cardiac output, vasoconstrictive, raising total peripheral resistance, and the effect that makes left ventricular pressure and arteriotony increase.Fructus Aurantii Immaturus and Fructus Aurantii decoct, to Isolated Toad Heart, make it shrink and strengthen during low concentration; During high concentration, asystole .N-methyltyramine also can be strengthened in vitro and at the contractility of systemic heart.
(2) water decoction, tincture and the fluid extract of the effect Fructus Aurantii Immaturus of gastrointestinal, Fructus Aurantii are all had to inhibitory action to the intestine in vitro of mice, rabbit and rabbit at body intestinal tube.It is strong that decocting liquid makes the gastrointestinal of stomach, intestinal fistula Canis familiaris L. shrink the rhythm and pace of moving things, is excitation, but suppress Canis familiaris L. at body gastrointestinal motility.Furctus Aurantii Immaturus extract shrinks and has obvious antagonism intestinal tube due to acetylcholine and histamine.
(3) to the effect Fructus Aurantii Immaturus in uterus and Fructus Aurantii decoct to mice isolated uterine, no matter pregnant or unpregnancy are mainly inhibitory action; In vitro or in body uterus, no matter pregnant or unpregnancy are all excitation to rabbit; Fistula of uterus is also had to significant excitation, can make uterine contraction strong, tonicity is strengthened, and even occurs tetanic property contraction. and the Isolated Rat Uterus that Fructus Aurantii Immaturus hot water extract causes 5-hydroxy tryptamine shrinks and has antagonism.
(4) the effect Furctus Aurantii Immaturus extract of nervus centralis is had to obvious sedation, can make mice quiet few moving; Without syngignoscism, but there is synergism with pentobarbital hypnosis; Furctus Aurantii Immaturus extract can make mice alleviate because of the pain reaction that acetic acid causes; Can reduce the fervescence that rabbit is caused by Typhoid Vaccine; Also have report to point out, (R)-4-isopropenyl-1-methyl-1-cyclohexene has central inhibitory action.
(5) diuresis Fructus Aurantii Immaturus and N-methyltyramine are all significantly increased the effect of urine amount to dog intravenous injection, and blood pressure and renal vascular resistance obviously increase simultaneously.This diuresis may be to produce by suppressing other effects such as reabsorption, irrelevant with the variation of renal blood flow and kidney filtrable volume.Also have report to think, Fructus Aurantii Immaturus by heart tonifying, shrink kidney blood vessel, increase filtration pressure and bring into play natriuretic diuretic effect.
(6) other effect researchs show, neohesperidin, naringin in Fructus Aurantii Immaturus have anti-inflammatory effect, have with the paeoniflorin in Radix Paeoniae the effect multiplying each other.
fructus Aurantii:bitter, pungent, sour, temperature.Return spleen, stomach warp.Dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.
Various Fructus Aurantiis are all containing materials such as volatile oil and flavonoid glycoside. in the peel of Citrus aurantium L. var. amara Engl. immature fruit, contain neohesperidin; During fruit maturation, neohesperidin disappears and naringin increases. connect in maturescent Citrus aurantium Linn. fruit containing vitamin C.From perfume (or spice) circle and the separated same alkaloid sample material that obtains Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus).
rhizoma Curcumae:pungent, bitter, temperature, returns liver, spleen channel, can removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, note of the ancient Chinese abdominal mass that can be used for caused by energy stagnation and blood stasis is gathered and trusted subordinate's stasis of blood pain etc.; Or in food stagnation abdominal distention.
In Rhizoma Curcumae, contain a large amount of volatile oil compositions, wherein RADIX CURCUMAE contains australene, nopinene, Camphora, 1,8-eudesmol, Borneolum Syntheticum, curcumenol, isocurcumenol etc.Guangxi zedoary contains australene, nopinene, limonene, Borneolum Syntheticum, Camphora, eugenol, zingiberene, curcumenol, curzerenone, fragrant zingiberone, turmerone, anhydrocurcolone etc.Rhizoma Curcumae volatile oil preparation, to the existing direct destruction of multiple cancerous cell, can strengthen specific immunity by immune system again and obtain obvious immunoprotective effec, thereby have antitumaous effect.Temperature Rhizoma Curcumae volatile oil can suppress the growth of various pathogens; 1% Oleum Curcumae has inhibitory action to animal acetic acid peritonitis, and mice local edema, inflammation are had to inhibitory action.Oleum Curcumae has obvious anti-ulcer effect.Water extraction liquid can anticoagulant, promotes arteriole restoration of blood flow, stops arteriole to shrink completely, obviously promotes local microcirculation to recover; Rhizoma Curcumae water extracting alcohol liquid is formed with inhibitory action to thrombus in vivo.In addition Rhizoma Curcumae has direct deactivation to respiratory syncytial virus, and Oleum Curcumae has and significantly protects the liver and antiearly pregnancy effect.
rhizoma Sparganii:pungent, bitter, flat.Return liver, spleen channel.Kind removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, for diseases such as lump in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pains.
Rhizoma Sparganii contains volatile oil, and in oil, main component is phenethanol, hydroquinone, hexadecylic acid, removes stem constuslactone etc. and multiple organic acid.The pool time of Rhizoma Sparganii water extract energy significant prolongation thrombin to human fibrin; Water decoction is anticoagulant significantly, reduces whole blood viscosity; Can obviously extend thrombin time of blood plasma and kaolin part clotting time; The outer thrombosis of energy antibody, and make thrombosis time lengthening, thrombosis contraction in length, thrombus weight alleviates, and can make euglobulin time shorten.Water decoction has excitation to isolated rabbit uterus.
endothelium Corneum Gigeriae Galli:sweet, cold.Return spleen, stomach, small intestinal, urinary bladder channel, there is the effect of promoting digestion and invigorating the stomach, arresting seminal emission.
In Endothelium Corneum Gigeriae Galli, contain gastric hormone, keratin, micro-pepsin, amylase, multivitamin and trace element, and 18 seed amino acids etc.After oral Endothelium Corneum Gigeriae Galli powder, gastric secretion, acidity and eupepsy are all shown in raising, and gastric motor function obviously strengthens; Experiment in vitro can strengthen pepsin, pancreatic lipase activity.
flos Inulae:bitter in the mouth, pungent, salty, warm in nature.Enter lung, liver, stomach warp.Energy expectorant, Hang Shui, sending down the abnormal ascending QI, preventing or arresting vomiting, softening the hard mass, cure mainly expectorant in the heart and tie, coerce lower distension, cough with asthma, singultus, saliva as shellac varnish, epigastric oppression and rigidity, eructation unrelieved, extensive abdominal edema.
The aerial parts that inula Britannica is bloomed period contains the multiple sterols such as Quercetin (Quercetin), isoquercitin (Isoquercetin), caffeic acid (Caffeic acid), chlorogenic acid (Chlorogenic acid), inulin and taraxasterol (Taraxasterol) containing sesquiterpene lactones compound Brevicornin Britanin (Britanin) and inulin (Inulicin), flower.It has following pharmacological action:
(1) the guinea pig bronchial spasmodic asthma relieving asthma, antitussive effect inula flavonoid causing histamine has significant protective effect; The guinea-pig isolated trachea spasm that histamine is caused also has antagonism, but compared with the effect of aminophylline slow and a little less than.Mice ammonia spraying method and the experiment of phenol red excretion method show: inula flavonoid is without antitussive and phlegm-dispelling functions, and every mouse peritoneal is injected 150% Flos Inulae decoct 0.1ml, within latter 1 hour, have remarkable antitussive effect, but expectorant effect is not obvious in injection.
(2) the fat-soluble and ether dissolubility that the root of antibacterial action inula Britannica and overground part divide partly has antibacterial action.Caffeic acid in Flos Inulae and chlorogenic acid have bacteriostasis more widely, but in vivo can be by protein deactivation.Dull and stereotyped paper disk method or trench method test show: Flos Inulae decoct (1:1) has obvious inhibitory action to staphylococcus aureus, anthrax bacillus and shigella flexneri II a strain, but the weak or unrestraint effect to the effect of the various pathogens such as Hemolytic streptococcus, escherichia coli, Bacillus typhi, bacillus pyocyaneus, Bacillus proteus, diphtheria corynebacterium.
(3) to the effect chlorogenic acid of smooth muscle, can significantly increase the small intestinal peristalsis of rat, mice; Chlorogenic acid, caffeic acid, quininic acid all can increase the tension force in uterus, but this interaction energy cancelled by papaverine, and atropine has no significant effect this.
(4) to central nervous system's effect chlorogenic acid and caffeic acid to Oral Administration in Rats or lumbar injection, all can improve the nerve excitability of rat.
(5) oral to effect chlorogenic acid and the caffeic acid of digestive system, can increase the secretory volume of hydrochloric acid in people's stomach; Also there is the effect that increases rat bile secretion.
(6) other effect zooperies show: in isolated rabbit ileum specimen, chlorogenic acid can strengthen adrenergic effect; But epinephrine is risen to hyperglycemia, prevention rat Ovum Gallus domesticus album ankle edema without impact.
fructus Mume:sour in the mouth, property is flat nontoxic, returns liver, spleen, lung large intestine channel, tool astringe the lung promote the production of body fluid, the merit of astringing intestine to stop diarrhea relieving colic caused by ascaris.
Fructus Mume is containing citric acid 19%, malic acid 15%, succinic acid, carbohydrate, sitosterol, ceroidlike material and oleanolic acid sample material.At mature period, contain hydrocyanic acid.The Fructus Mume that processes from strand is dry containing citric acid 50%, malic acid 20%, also contains strong bactericidal properties and improves the composition picric acid of liver function and have the almond glycoside of hot analgesic activity.Still the superoxide dismutase (SOD) that contains greater activity in Fructus Mume sarcocarp.Fresh Fructus Mume fruit is containing pectin.Fructus Mume seed is containing amygdalin. and water decocted solution of fructus mume (1:1) all has inhibitory action to anthrax bacillus, diphtheria and diphtheroid, bacillus subtilis, staphylococcus (golden yellow, lemon yellow, white), streptococcus pneumoniae, also effective to enteral pathogenic bacterium such as escherichia coli, bacterium sonnei, Bacillus proteus, Typhoid and paratyphoid bacillus, bacillus pyocyaneus, vibrio cholera, and to first or second kind streptococcus without effect.Fructus Mume soup has and promote to shrink and choleretic effect gallbladder, be beneficial to drain biliary tract bile, reduce and prevent biliary tract infection.Fructus Mume has increase appetite, facilitating digestion, the effect of saliva stimulating gland, gastric gland secrete digestive juices; Also there is significant whole intestinal effect, promote enterokinesia, diminish inflammation; There is again the effect of shrinking intestinal wall, thereby can be used for the treatment of diarrhoea simultaneously.
caulis Akebiae:bitter in the mouth, cool in nature, GUIXIN, lung, small intestinal, urinary bladder channel, tool clearing away heat and promoting diuresis, the merit of the stimulating milk secretion of stimulating the menstrual flow.
Caulis Akebiae is containing akebin (Akebin), and akebin is hydrolyzed to obtain hederagenin, oleanolic acid, glucose and rhamnose; Still containing potassium salt 0.254%.Caulis Aristolochiae Manshuriensis is containing Aristolochic Acid (Aristolochic acid), hederagenin (Hederagenin), oleanolic acid (Oleanolic acid) etc.
The effect of Caulis Akebiae:
(1) effect to cardiovascular system: Caulis Aristolochiae Manshuriensis decoct (0.5～2g/kg) is given anesthetized rabbit and dog intravenous injection, can make its blood pressure increase immediately, then declines, and is long-term Secondary cases Blood pressure drop phenomenon.Indivedual rabbits only have Blood pressure drop.Caulis Aristolochiae Manshuriensis decoct has similar digitaloid effect to the heart of Isolated Toad, Cavia porcellus, studies have shown that this effect is caused by wherein contained calcium and tannic acid.
(2) effect to smooth muscle: Caulis Aristolochiae Manshuriensis decoct has excitation to isolated mouse small intestinal, has inhibitory action to isolated mouse unpregnancy and pregnant uterus.Aristolochic Acid has contraction to rabbit in the body uterus of body and intestine in vitro.
(3) diuresis: experiment showed, that Caulis Akebiae has obvious diuresis.Caulis Akebiae tincture is oral to rabbit, to rabbit, oral or intravenous injection has significant diuresis to Caulis Akebiae decoct.
fructus Crotonis:acrid in the mouth, hot in nature, very toxic.Enter stomach, large intestine, lung meridian.Can rush down cold long-pending, orifice opening, by expectorant, Hang Shui, parasite killing, cure mainly coldly long-pendingly stagnate, distension and fullness of the chest and abdomen shoot, abdominal mass due to blood stasis, accumulation of phlegm in the hypochondrium, dysentery, edema, external control acute throat trouble, sore throat, malignant boil scabies, nevus verrucosus etc.
In Fructus Crotonis seed, contain Oleum Tiglii, Fructus Crotonis-12,13-diester, crotonyl alcohol. three esters also claim crotin containing a kind of toxicity globulin simultaneously, contain stronger zest.Making drugs into frostlike powder process can reduce the oil content of Fructus Crotonis, and makes crotin inactivation, reduces zest.
fructus Crataegi: sour, sweet, tepor.Return spleen, stomach, Liver Channel.The effect with promoting digestion and removing stagnation, promoting blood circulation to remove blood stasis.In Fructus Crataegi, contain chlorogenic acid (chlorogenic acid), caffeic acid, Crataegolic acid (crataegolic acid), neat chrysanthemum fruit acid, Quercetin, ursolic acid, oleanolic acid, hyperin (hyperin), epicatechin (epicatechin) etc.
The main component of Fructus Crataegi is Flavonoid substances, and cardiovascular system is had to obvious pharmacological action.At present, from Fructus Crataegi, separated flavone component has more than 30 to plant, and mainly contains flavonoid glycoside, flavonol and glycoside thereof, dioxygen flavonoid glycoside, polymerization flavonoid containing carbon bond.The composition of another kind of outbalance is triterpene substance, has heart tonifying, increases coronary blood flow, improves the important function such as blood circulation.In addition, in Fructus Crataegi, contain organic acid as chlorogenic acid, caffeic acid and tannin, the acid anhydride of tanning, epicatechol, choline, acetylcholine, Sitosterolum, carotene and a large amount of Vit C etc.
The effect of Fructus Crataegi:
(1) anti-cancer, anticancer research in recent years are found, contain a kind of compound that is vitexin in Fructus Crataegi, have anticancer effect.Nitrosamine, flavacin all can bring out the generation of alimentary tract cancer or increase the weight of, and experimentation shows, what hawthorn extract can not only blocking nitrosamine formation is synthetic, also can suppress the carcinogenesis of flavacin.So the high-risk group of alimentary tract cancer is edible haw often, for the patient who suffers from cancer, if while there is dyspepsia also available Fructus Crataegi, rice cook congee together edible, so both can be aid digestion, can play again auxiliary anticancer effect.
(2) heart tonifying, blood fat reducing, blood pressure lowering clinical research confirmation, Fructus Crataegi can significantly reduce serum cholesterol and triglyceride, effectively prevents and treats atherosclerosis; Fructus Crataegi can also play heart tonifying and prevent anginal effect by strengthening myocardial contraction, increase cardiac output, coronary artery dilator blood vessel, increase coronary flow, reduction myocardial oxygen consumption etc.In addition, the total flavones in Fructus Crataegi has the effect of blood vessel dilating and lasting blood pressure lowering.Therefore, hyperlipidemia, hypertension and patients with coronary heart disease, every day, desirable Fructus Crataegi was 15～30 grams, and decocting is for tea-drinking.
(3) treatment dysmenorrhea, the menoxenia traditional Chinese medical science thinks that Fructus Crataegi has the effect of activating blood circulation to dissipate blood stasis, is blood stasis type dysmenorrhea patient's dietetic therapy good merchantable brand.Blood stasis type dysmenorrhea patient often shows as and passes through 1st～2 days or lower abdomen pain occurs for premenstrual 1～2 day, and when menses are discharged smoothness, pain alleviates gradually or disappears, and menses darker in color, with clot.1000 grams of the desirable complete band core fresh Fructus Crataegi of patient, add suitable quantity of water after cleaning, and slow fire infusion is thoroughly cooked to Fructus Crataegi, adds 250 grams, brown sugar, then infusion 10 minutes, treat that it becomes scattered paste shape.Premenstrual 3～5 days start to take, and sooner or later respectively eat 30 milliliters, Fructus Crataegi mud every day, until through after within 3 days, cut out, this is 1 course for the treatment of, serveing on 3 courses for the treatment of can take effect.This method is also applicable to menoxenia, Chinese medical discrimination is blood stasis person.
In prescription provided by the invention, the pain relieving of Radix Aucklandiae energy warming middle-JIAO to promote flow of QI, strengthening the spleen to promote digestion intestinal stasis relieving, be monarch drug.The merit of Fructus Aurantii Immaturus, the equal tool dispelling the stagnated QI of Fructus Aurantii removing food stagnancy, Fructus Aurantii Immaturus is apt to help digestion long-pending, and Fructus Aurantii is apt to cool down long-pending; Gas in the kind treating blood disorders of Rhizoma Curcumae, the blood that Rhizoma Sparganii is kind in regulating the flow of vital energy, this four taste is ministerial drug.Endothelium Corneum Gigeriae Galli, Fructus Crataegi all have the effect that promoting digestion and invigorating the stomach, dyspepsia are not changed, Flos Inulae stopping nausea and vomiting by lowering the adverse flow of QI, and Fructus Crotonis cures mainly distension and fullness of the chest and abdomen, is adjuvant drug.Vinegar can whet the appetite, promote the secretion of saliva and gastric juice, helps digest absorption, makes honey stomach, promoting digestion and removing stagnation; With vinegar, concoct Fructus Mume, can strengthen the effect of Fructus Mume, the stimulate the menstrual flow heat of stimulating milk secretion, the small intestinal that drops of Caulis Akebiae, plays the effect that makes medicine jointly.
The specific embodiment
Below in conjunction with specific embodiment, the present invention will be further described.
embodiment 1
A kind of depressed Chinese medicine composition of pig appetite for the treatment of, in weight portion, comprising: 20 parts of the Radix Aucklandiae, 20 parts of Fructus Aurantii Immaturuss, 22 parts of Fructus Aurantiis, 30 parts of Rhizoma Curcumae, 30 parts of Rhizoma Sparganii, 20 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Flos Inulaes, 20 parts of Fructus Crataegis, 20 parts of Fructus Mumes, 20 parts of Caulis Akebiaes, 4.5 parts of Fructus Crotonis.
In top, Fructus Crotonis making drugs into frostlike powder, the vinegar process of preparing Chinese medicine for Fructus Mume, enucleation, oven dry, together pulverize as end with Fructus Mume after all the other raw material stoving, crosses 60 mesh sieves, adds Semen Crotonis Pulveratum mix homogeneously and get final product.Bake out temperature is 60 ℃
embodiment 2
A kind of depressed Chinese medicine composition of pig appetite for the treatment of, in weight portion, comprising: 18 parts of the Radix Aucklandiae, 18 parts of Fructus Aurantii Immaturuss, 20 parts of Fructus Aurantiis, 33 parts of Rhizoma Curcumae, 27 parts of Rhizoma Sparganii, 18 parts of Endothelium Corneum Gigeriae Galli, 4.5 parts of Flos Inulaes, 22 parts of Fructus Crataegis, 18 parts of Fructus Mumes, 22 parts of Caulis Akebiaes, 5.5 parts of Fructus Crotonis.
In top, Fructus Crotonis making drugs into frostlike powder, the vinegar process of preparing Chinese medicine for Fructus Mume, enucleation, oven dry, together pulverize as end with Fructus Mume after all the other raw material stoving, crosses 60 mesh sieves, adds Semen Crotonis Pulveratum mix homogeneously and get final product.Bake out temperature is 65 ℃
embodiment 3
A kind of depressed Chinese medicine composition of pig appetite for the treatment of, in weight portion, comprising: 22 parts of the Radix Aucklandiae, 22 parts of Fructus Aurantii Immaturuss, 18 parts of Fructus Aurantiis, 27 parts of Rhizoma Curcumae, 33 parts of Rhizoma Sparganii, 22 parts of Endothelium Corneum Gigeriae Galli, 5.5 parts of Flos Inulaes, 18 parts of Fructus Crataegis, 18 parts of Fructus Mumes, 18 parts of Caulis Akebiaes, 5 parts of Fructus Crotonis.
In top, Fructus Crotonis making drugs into frostlike powder, the vinegar process of preparing Chinese medicine for Fructus Mume, enucleation, oven dry, together pulverize as end with Fructus Mume after all the other raw material stoving, crosses 60 mesh sieves, adds Semen Crotonis Pulveratum mix homogeneously and get final product.Bake out temperature is 62 ℃
embodiment 4
Treat the depressed Chinese medicine composition of pig appetite, in weight portion, comprising: 20 parts of the Radix Aucklandiae, 18 parts of Fructus Aurantii Immaturuss, 19 parts of Fructus Aurantiis, 28 parts of Rhizoma Curcumae, 30 parts of Rhizoma Sparganii, 20 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Flos Inulaes, 22 parts of Fructus Mumes, 21 parts of Caulis Akebiaes, 5 parts of Fructus Crotonis.
In top, Fructus Crotonis making drugs into frostlike powder, the vinegar process of preparing Chinese medicine for Fructus Mume, enucleation, oven dry, together pulverize as end with Fructus Mume after all the other raw material stoving, crosses 60 mesh sieves, adds Semen Crotonis Pulveratum mix homogeneously and get final product.Bake out temperature is 60 ℃
embodiment 5 effect tests
Apply Chinese medicine composition of the present invention and to amounting to 408 pigs, carry out clinical practice experiment on 15 pig farms, in these pigs, some is not eat at the inappetence or the low temperature that occur to occur after other diseases, have plenty of sow and occur inappetence, food even puerperal, another part is directly to have occurred that low temperature do not eat or eat less symptom, and weak effect after other drug treatment on probation, mortality rate are high.
(1) experimental program: morbidity pig farm is to the inactive other drug of the sick pig that inappetence occurs or do not eat, apply Chinese medicine composition of the present invention, use 6～10 days continuously, coordinate and improve feeding and management condition simultaneously, strengthen sterilization, and in drinking-water, add 0.5% glucose, 0.1% electrolysis multidimensional, 0.1% oresol, to strengthen resistivity.Observe during this time disease hog condition, Estimating curative effect.
(2) curative effect judgement:
Recovery from illness: use sick pig in Chinese medicine composition of the present invention 10 days to recover normal appetite and the mental status.
Effective: use Chinese medicine composition of the present invention 10 days, sick pig recovers appetite 70%, and spirit is normal.
Take a turn for the better: use Chinese medicine composition of the present invention 10 days, aphagia shape is alleviated to some extent, and spirit is slightly poor.
Invalid: use continuously this medicine 10 days, symptom loses improvement.
(3) experimental result: to the application of 408 ill pigs Chinese medicine composition of the present invention, that wherein cures completely has 133, significant 201 of effect, 36 of improvement, invalid 38.Hence one can see that, utilizes the low temperature aphagia of traditional Chinese medicine composition for treating pig of the present invention, and effective percentage reaches 91%, evident in efficacy.
The specific experiment situation on wherein several pig farms below:
experiment 1:zhongmou County large-scale pig farm, 10000 of live pig livestock on hands.Winter in 2011, temperature declines suddenly, and inappetence has appearred in part growing and fattening pigs, the symptom that even low temperature is not eaten, and application other drug therapeutic effect is poor, and sick pig consumes very fast, and mortality rate is high, has caused larger economic loss.After 21 isolated rearings of pig of falling ill, according to the Chinese medicine composition administration of embodiment 1, every 100kg body weight administration 30g, gavages or directly mixes a small amount of concentrate twice on the one and feed.The 3rd day, most sick pigs started to search for food, and spirit takes a turn for the better; Continue to feed said composition to the 6 days, it is normal that swinery recovers completely.
experiment 2:large-scale pig farm, Kaifeng, 35 age in days left and right piglets are suffered from diarrhoea, and after curing, approximately 50 piglets do not eat, then with the Chinese medicine composition of embodiment 4, treat, every piglet medication 5～10g, twice on the one water punching gavages.Strengthen feeding and management simultaneously, improve colony house temperature, and in drinking-water, add 0.5% glucose, 0.1% electrolysis multidimensional, 0.1% oresol, to strengthen resistivity.After the said composition of feeding the 2nd day, most of piglet started to search for food, and spirit takes a turn for the better to some extent, continues to feed 3 days, does not eat disease and is almost recovered, and it is normal that sick pig recovers.
experiment 3:linzhou City's large-scale pig farm, summer in 2012, heat, disease is not eaten in fattening house part growing and fattening pigs (about 80kg) appearance suddenly.By field investigation, finding afterwards, may be that temperature is higher, the disorderly institute of the digestive function of pig causes.Select 80 of inappetence, the disease of not eating food pigs, then with the Chinese medicine composition of embodiment 2, treat, every pig medication 40g, twice on the one water punching gavages or directly mixes a small amount of concentrate and feed.Strengthen feeding and management simultaneously, reduce colony house temperature.From the Chinese medicine composition of the present invention the 4th day of feeding, aphagia takes a turn for the better greatly, and it is normal that 50% pig appetite is recovered, the mental status is good, and the sick pig not recovering completely continues medication 4 days, swinery recovers normally substantially, eliminates the pig that part is seriously ill, therapeutic effect is bad, and pig farm returns to normal production.
experiment 4:in December, 2012,4 tire sows of port owned by the government town, Zhongmou County Lee's raising do not eat puerperal always.Clinical symptoms shows as lassitude, and sleeping drive and be reluctant to walk about on the ground, 38.6 ℃ of body temperature, defecation is dry is spherical, and mouthful color, conjunctiva color are light pure, and after three days, milk amount falls sharply, and is diagnosed as aphagia in puerperal.With the Chinese medicine composition of embodiment 4, treat immediately, every 100kg body weight administration 25～30g, one day twice, water punching gavaged or mixes a small amount of concentrate and feeds.The 3rd day, this pig started to search for food, and spirit takes a turn for the better to some extent, continued medication 3 days, and appetite, complete mental recover normal, breast is measured increases.
experiment 5:in July, 2013, there is not eating phenomenon in 2 sows that Xing Zhuan township, Weizhi County, Kaifeng department raises puerperal.Wherein a body weight is about 148kg, in 14 of farrowing on July 9; A body weight is about 220kg, in 16 of farrowing on July 5.Two sow occurred respectively not eating phenomenon about 3 days puerperal, and local veterinary has no improvement for 3 days with benzylpenicillin potassium, 30% dipyrone, dexamethasone in treatment, and still effect is not good enough, escalated dose constant in said medicine in the situation that.In laboratory diagnosis, get rid of under the prerequisite of highly pathogenic PRRS, treat immediately with the Chinese medicine composition of embodiment 3, every sow is according to the dose administration of every 100kg body weight 25～30g, and water punching gavages or mixes a small amount of concentrate and feeds.Treat symptom after 4 days and alleviate to some extent, appetite increases to some extent, and energy normal lactation, is used in conjunction again 4 days, and each sow appetite is recovered normally completely, and the mental status is good.By paying a return visit, do not have a rebound.
Claims (4)
1. treat the depressed Chinese medicine composition of pig appetite for one kind, in weight portion, comprising: 18～22 parts of the Radix Aucklandiae, 18～22 parts of Fructus Aurantii Immaturuss, 18～22 parts of Fructus Aurantiis, 27～33 parts of Rhizoma Curcumae, 27～33 parts of Rhizoma Sparganii, 18～22 parts of Endothelium Corneum Gigeriae Galli, 4.5～5.5 parts of Flos Inulaes, 18～22 parts of Fructus Mumes, 18～22 parts of Caulis Akebiaes, 4.5～5.5 parts of Fructus Crotonis.
2. the depressed Chinese medicine composition for the treatment of pig appetite as claimed in claim 1, is characterized in that, described Chinese medicine composition also comprises Fructus Crataegi 18～22 weight portions.
3. the depressed Chinese medicine composition for the treatment of pig appetite as claimed in claim 1 or 2, it is characterized in that, described Chinese medicine composition is powder, wherein Fructus Crotonis making drugs into frostlike powder, the vinegar process of preparing Chinese medicine for Fructus Mume, enucleation, oven dry, after all the other raw material stoving, together pulverize as end with Fructus Mume, cross 60 mesh sieves, add Semen Crotonis Pulveratum mix homogeneously and get final product.
4. the depressed Chinese medicine composition for the treatment of pig appetite as claimed in claim 3, is characterized in that, described bake out temperature is 60 ~ 65 ℃.
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| CN105168539A (en) * | 2015-09-16 | 2015-12-23 | 张霞 | Traditional Chinese medicine composition for treating aphagia of postpartum sows |
| CN106990182A (en) * | 2017-04-06 | 2017-07-28 | 广州市香雪制药股份有限公司 | The characteristic spectrum of Inula britannica chinensis granule is set up and detection method |
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| CN102526565A (en) * | 2012-01-12 | 2012-07-04 | 王玉琳 | Chinese medicament for treating gastrolithiasis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105168539A (en) * | 2015-09-16 | 2015-12-23 | 张霞 | Traditional Chinese medicine composition for treating aphagia of postpartum sows |
| CN106990182A (en) * | 2017-04-06 | 2017-07-28 | 广州市香雪制药股份有限公司 | The characteristic spectrum of Inula britannica chinensis granule is set up and detection method |
| CN106990182B (en) * | 2017-04-06 | 2019-11-05 | 广州市香雪制药股份有限公司 | The characteristic spectrum of Inula britannica chinensis granule is established and detection method |
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