CN103099885A - Soft capsules having acne removing function and preparation method thereof - Google Patents

Abstract

The invention mainly relates to soft capsules having an acne removing function. The soft capsules are characterized by comprising the following raw materials according to parts by weight: 300-520 parts of linseed oil, 10-30 parts of scutellaria baicalensis extract, 10-30 parts of salviae miltiorrhizae extract, 10-30 parts of prepared rehmannia root extract, 10-30 parts of poria extract, 10-30 parts of barbados aloe extract, 10-30 parts of honeysuckle extract, 10-30 parts of radix angelicae extract, 10-30 parts of jasmine extract and 10-30 parts of dandelion extract. Guided by the traditional Chinese medicine theory and based on the modern research result of the traditional Chinese medicine, the soft capsules have the characteristics of elaborate material selection, rigorous composition and reasonable combination. In the formula, the scutellaria baicalensis functions in purging fire for removing toxin; the barbados aloe functions in cleaning intestinal canal and eliminating dampness; the prepared rehmannia root functions in nourishing yin and supplementing blood, and strengthening and nourishing marrow and essence; the salviae miltiorrhizae functions in promoting blood circulation for regulating menstruation, and dispelling stasis and stanching bleeding; the honeysuckle functions in resisting inflammation and dissipating heat; the jasmine functions in stopping bleeding and diminishing swelling; the dandelion functions in clearing away heat and toxic materials, and resolving carbuncle and expulsing boil; the poria cocos functions in eliminating dampness and diuresis; the radix angelicae functions in relieving swelling and pain; and the linseed oil functions in softening blood-fat blood vessels and protecting the heart. The formula improves the body condition on the whole and removes acnes.

Description

Has acne-dispelling function soft capsule and preparation method thereof

Technical field:

The present invention relates generally to soft capsule that has acne-dispelling function and preparation method thereof.

Background technology:

At present, has the formula of acne-dispelling function, existing relevant report.The weak point of existing Therapeutic Method:

1, patients with acne is many at present, and the cause of disease is complicated, and Therapeutic Method is varied clinically, does not have unified Therapeutic Method effect relatively poor;

2, clinically mainly with the western medical treatment acne, adopt respectively the adjusting androgen secretion according to its pathogenesis, reduce smegma, reduce sebaceous gland duct and block, bactericidal antiphlogistic etc. carry out part and whole body therapeutic.Because of to the pathogenetic judgement of concrete disease misalignment sometimes, cause treatment not suit the remedy to the case, often get half the result with twice the effort.

3, in treatment, the traditional Chinese medical science is main mainly with heat and toxic materials clearing away medicine, or single or compound recipe, receive certain effect, but the course for the treatment of is longer, and onset is slower.

4, some is treated with simple medicine for external use, and effect is poorer.

But the present invention be directed to the weak point of existing therapeutic scheme or product, formulate comparatively comprehensively therapeutic scheme.The traditional Chinese medical science thinks that different acnes have different mechanism, generally has due to lung, spleen, stomach, intestinal dysphoria with smothery sensation.Therefore the traditional Chinese medical science thinks that Pathogenesis of Acne is as follows: lung stomach heat in blood, and the intestines and stomach intrinsic heat, expectorant stagnant heat knot, the spleen channel intrinsic heat is due to the reasons such as deficiency of kidney yin.

The present invention is directed to the methods such as pathogenesis integrated use clearing away heat and eliminating dampness, eliminating fire and detoxication, removing heat from blood and promoting blood circulation, enriching yin and nourishing kidney of acne, comprehensively conditioning; Remarkable through clinical trial result.Make up the weak point of existing Therapeutic Method, demonstrated fully the advantage of the whole conditioning of Chinese medicine.

Summary of the invention:

The object of the invention is to avoid the deficiencies in the prior art part and a kind of soft capsule with acne-dispelling function and preparation method thereof is provided, the problem that exists to solve prior art.

Purpose of the present invention can be by realizing by the following technical solutions: a kind of soft capsule with acne-dispelling function, its main feature are the raw materials that includes following weight portion: siritch 300-520 weight portion, Radix Scutellariae extract 10-30 weight portion, Radix Salviae Miltiorrhizae extract 10-30 weight portion, Radix Rehmanniae Preparata extract 10-30 weight portion, Poria extract 10-30 weight portion;

Described soft capsule with acne-dispelling function also includes the raw material of following weight portion: Aloe extract 10-30 weight portion, Flos Lonicerae extract 10-30 weight portion, Radix Angelicae Dahuricae extract 10-30 weight portion;

Described soft capsule with acne-dispelling function also includes the raw material of following weight portion: Fructus Gardeniae extract 10-30 weight portion, Herba Taraxaci extract 10-30 weight portion;

A kind of preparation method with soft capsule of acne-dispelling function, its main feature is, comprises the steps:

(1) raw material preparation

Radix Scutellariae, Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Poria, Flos Lonicerae, Aloe, Fructus Gardeniae, the Radix Angelicae Dahuricae, Herba Taraxaci are carried out respectively selected, rinsing twice is drenched and to be anhydrated minute; Be 60～80 ℃ of oven dry 1.5-2 hour in temperature, making its moisture is 5-6%, after coarse pulverization granularity be 5-50mm to add water be 8 times of material, lixiviate 2-8 hour, extract 2 times; Twice filtrate merged, concentrated, be 60-80 ℃ of oven dry 1.5-2 hour in temperature, make its moisture 5-6% of being divided into; Pulverize, sieve, granularity is 0.1-0.5mm, is the Chinese medicine extract fine powder.

The selected slag of removing of flaxseed; Adopt pressafiner that selected flaxseed is squeezed; Again siritch is removed slag, add water and regulate pH value 5.5-6.5, at water temperature 55-65 ℃, fully stir, remove moisture after then precipitating two hours namely to get the refine siritch;

(2) with siritch, the extracts such as Radix Scutellariae, Aloe, Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Flos Lonicerae, Fructus Gardeniae, Herba Taraxaci, Poria, the Radix Angelicae Dahuricae mix in proportion;

(3) press 0.6g/ grain dress soft capsule after mix homogeneously;

(4) sterilization bottling, vanning.

1, the invention has the beneficial effects as follows: the method screening raw material that our section of use emulates the advanced, rigorous prescription, the check of the various raw materials of process and chemical analysis thereof, function, the total analysis result of the present invention of cash is as follows:

(1) Radix Scutellariae:

For labiate Radix Scutellariae (Scutellaria baicalensis Georgi), be used as medicine with root.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are used in the fungal culture miscellaneous bacteria and infect special severity by the strong characteristics of broad-spectrum antibacterial action, and are fine with Radix Scutellariae extracting solution effect, and it is the optimal Herba indigoferae Pseudotinctoriae of agricultural disease control.

Baicalin has the antibacterial activity [1 of wide spectrum, 2], as the thalline such as staphylococcus aureus, Hemolytic streptococcus, streptococcus pneumoniae, meningococcus, vibrio cholera and diphtheria, anthrax, dysentery, green pus, typhoid fever and Bu Shi there being inhibitory action in various degree.Isolated experiment shows, baicalin suppresses propionibacterium acnes under same concentrations effect is 2 times of metronidazole, is 1.5 times of red syphilis.The phagocytic function of macrophage can be promoted due to baicalin, therefore the dead cell in cyst type acne, dead thalline and other residues can be effectively removed, the recovery from illness of accelerates acne, and be difficult for staying spot more.

The Radix Scutellariae clearing away heat and eliminating dampness, interior external all can.Contain testosterone 5a-reductase inhibitor in Radix Scutellariae, can suppress the generation of dihydrotestosterone in sebaceous gland, and Propiobacterium is had good killing action.

The effect of Radix Scutellariae:

1, be used for hygropyrexia heating, uncomfortable in chest, feeling thirst but no desire to drink, and the diseases such as damp-heat dysentery, jaundice.To the hygropyrexia heating, with fit applications such as Talcum, roud cardamon seed, Poria; To damp-heat dysentery, stomachache, be equal to use with the Radix Paeoniae Alba, Radix Puerariae, Radix Glycyrrhizae; Jaundice for due to damp-heat accumulation can be equal to use with Herba Artemisiae Scopariae, Fructus Gardeniae, Herba Lophatheri.

2, be used for the high hot excessive thirst of calentura, or the cough due to lung-heat, or the intenseness of heat forcing blood is excessive and pathopyretic ulcer etc.Control the high heat of calentura, the compatibilities such as normal and Rhizoma Coptidis, Fructus Gardeniae; Control the cough due to lung-heat, can be equal to use with the Rhizoma Anemarrhenae, Cortex Mori; Control bleeding due to blood-heat, can be equal to use with the Radix Rehmanniae, Cortex Moutan, Cacumen Platycladi; To pathopyretic ulcer, can be with medicines such as Flos Lonicerae, Fructus Forsythiaes with using.

The pharmacological action of Radix Scutellariae:

1, the pharmacological action relevant to effect: 1. antibiotic, antiviral; 2. antiinflammatory; 3. on the impact of immunologic function; 4. analgesic; 5. protect the liver, function of gallbladder promoting (liver heat removing gallbladder), protect the liver, relevant with antioxidant radical damage; 6. calm, maincenter suppresses; 7. blood system is affected.

2, other pharmacological actions: 1. blood fat reducing, atherosclerosis; 2. antioxidant radical damage: suppress the generation of lipid peroxide (LPO), remove free radical.3. blood pressure lowering: directly expand peripheral blood vessel; Suppress vasomotor center.

(2) Aloe:

For only tail grass section herbaceos perennial, according to wild aloe kind kind more than 300 of textual criticism, mainly be distributed in the ground such as Africa.This kind of plant is liked by masses quite, mainly because it is easy to plantation, and the ornamental plant that has both for floral leaf.Edible kind only has six kinds, and in the middle of have the valuable Aloe kind of medicine and mainly contain: foreign Aloe (having another name called barbados aloe or Aloe Barbadensis Miller Aloe Barbadensis/Aloe Vera) Aloe vulgaris (be distributed in Africa is northern, the West Indies), Aloe ferox Miller (being distributed in the south, Africa), Yuanjiang River Aloe etc.

Aloe bowel relieving dampness removing, interior external all can.Anthraquinones emodin in Aloe suppresses the anaerobe effect and slightly is better than metronidazole, experimental results show that emodin all can suppress detesting property medium leukotriene B under condition in vivo and in vitro ₁Biosynthesis, be the inhibitor of arachidonic acid lipoxygenase, can effectively reduce the inflammatory reaction of acne, thereby reduce the skin lesion of acne, cicatrix is glutinous to be connected.

The Aloe effect:

1, comprehensive adjusting immunity of human body (being resistance), recover without treatment some chronic diseases;

2, promote cell regeneration, tissue injured and sclerosis is got well;

3, blood circulation promoting is got rid of vivotoxin;

4, Aloe is called as the treasure-house of vitamin, aminoacid and mineral, can replenish these materials of needed by human body.

The effect of Aloe: the composition that all contains Aloe in many cosmetics.Rare is, directly Fresh leaf of aloe is coated on the face way.This one time of face-beautifying method that is called as genuineness buds out into popularity, and removing to buy Folium Aloe to the market also becomes new fashion behavior.Here, we introduce the general knowledge of some aloe beauties, perhaps can help everybody correctly to use aloe beauty.

Aloe Barbadensis Miller is the directly Fresh leaf of aloe of beauty treatment of optimum, i.e. Aloe vulgaris, and it has the performance of the skin contraction of making, softization, moisturizing, antiinflammatory, bleaching.Remove in addition sclerosis, keratinization, improve the effect of scar, little wrinkle, eye pouch, cutis laxa can not only be prevented, skin wetness, tender and lovely can also be kept, simultaneously, can also treat scytitis, acne, freckle, acne and scald, knife injury, insect bite etc. are also had good curative effect.Effective too to hair, can make hair keep moistening smooth, pre-Anti-hair loss.

The pharmacological action of Aloe:

1, rush down under: in all Radix Et Rhizoma Rhei glycoside cathartics, the zest of Aloe is the strongest, rush down lower in significant stomachache and pelvic congestion, can cause nephritis when serious.The Main Function position of Aloe is at large intestine, to small intestinal without promoting creeping effect.

2, promote healing: artificial wound Mus back of the body Aloe is had the healing of promotion effect; Rabbit Aloe to the artificial conjunctiva edema can shorten curative day.Aloe juice preparation all has protective effect to skin trauma, burn and the local irradiation of x line.

3, other: (1) is anticancer: Aloe extract has inhibitory action to sarcoma S180 and ehrlich carcinoma.(2) antifungal: the aloe water preserved material in vitro has in various degree inhibitory action to the various skin fungus.

Aloe has good treatment wound, once uses Aloe soaking object (10% solution) in the rabbit of artificial conjunctiva edema, can shorten curative day; The Mus back of the body to artificial wound also has the effect of slight promotion healing.In recent years, make with the Folium Aloe juice and contain polysaccharide (poly-gel preparation is used for skin or other tissue injury and burn, and even someone thinks and may be used for anti Bacillus pyocyaneu Flugge.Prove with tissue culture method, the toxicity of this Aloe gel is lower.Aloe extract makes ointment, and mice local irradiation x-ray is had slight protective effect.

(3) Radix Rehmanniae Preparata:

Radix Rehmanniae Preparata Shudihuang is the tuber of scrophulariaceae rehmannia glutinosa plant R ehmannia glutinosa (Gdertn) Iibosch., concocts through processing to form.Usually through repeatedly steaming solarization, glossy to inside and outside darkish complexion, the quality softness is sticky as adjuvant take wine, Fructus Amomi, Pericarpium Citri Reticulatae; Meridian distribution of property and flavor: sweet, tepor.Return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, beneficial essence is filled out marrow.Be used for the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.

contain Herba Leonuri glycoside (leonuride), aucubin (aucubin), catalpol (catalpol), rehmannioside (rehmannioside) A, B, C, D, U.S. profit appropriate pair of glycoside (melittoside), rehmanin (rehma-glutin) A, D, the smelly formaldehyde glycoside of Radix Rehmanniae chlorination (glutinoside), burnt rehmanin (jioglutin) A, B, C, burnt Radix Rehmanniae lactone (jioglutolide), burnt jiofuran (jiofuran), , the bitter glycoside unit of Radix Rehmanniae (rehmapicrogenin), separately contain trihydroxy-alpha, beta-lonone (trihydroxy-β-lonone), dihydroxy-alpha, beta-lonone (dihydroxy-p-lonone), aeginetic acid (aegineticacid), 5-hydroxyl aeginetic acid (sec-hydroxyaeginetic acid), succinic acid (succinic acid), 5-pidolic acid (5-oxoproline), 5-HMFA (5-hydroxymethylfuroic acid), uracil (uracil), uridine (uridine) etc.separate from ligroin extraction again and obtain: linoleic acid (linoleic acid), Palmic acid (palmitic acid), stearic acid (stearic acid), arachidic acid (arachidic acid), behenic acid (be-henic acid), pentadecanoic acid (pentadecanoic acid), palmitoleic acid (palmitoleic acid), myristic acid (myristic acid), 19 carbonic acid (nonadecanOic acid), 20-carbonic acid (heneicosanoic acid), 17 carbonic acid (margaric acid).

Dietary function: sweet in the mouth, slightly warm in nature.The YIN nourishing of enriching blood, strengthening and nourishing marrow and essence.Be used for blood deficiency, shallow complexion, dizzy cardiopalmus; Blood deficiency, menoxenia, metrorrhagia is lost blood; Yin asthenia generating intrinsic heat, osteopyrexia and fever, night sweat; Deficiency of the kidney yin, the xerostomia of quenching one's thirst; Liver and kidney two void, asthenia of essence and blood, soreness of the waist and knees, vertigo and tinnitus, early whitening of beard and hair.Alone, or with Radix Angelicae Sinensis compatibility stewed chicken, be used for syndrome of deficiency of blood or menoxenia; Join the Radix Astragali, Rhizoma Dioscoreae, Radix Asparagi, fry in shallow oil the soup drink, be used for quenching one's thirst (diabetes); Join Fructus Lycii, Semen Cuscutae, Fructus Rubi infusing drugs in wine, anti-ageing in order to tonify deficiency.Available 15～30g on the one.

Tcm clinical practice confirms, hyperactivity of fire caused by deficiency of YIN be acne morbidity this, deficiency of kidney yin, the liver failing to maintain the normal flow of QI make woman's disharmony of Chong and Conception Channels, and cause acne and send out with menstrual synchrony.The Rehmannia glutinosa Libosch Water decoct can obviously reduce the excretion of mouse retention albumen, improves the case variations such as glomerular epithelium cell podocytic process fusion.Thereby kidney tonifying YIN nourishing.The Rehmannia glutinosa Libosch Water decoct all has inhibitory action to funguses such as palpus skin ulcer Xian bacterium, the little sporeformer of Gypsum Fibrosum sample, the little sporeformer of hair shape, can effectively suppress the anaerobe in acne, coryneform breeding.

Modern study:

1. chemical composition: this product contains catalpol, rehmanin, mannitol, retinoid material, saccharide and aminoacid etc.

2. pharmacological action: Radix Rehmanniae can be resisted the decline of taking continuously plasma corticosterone concentration after dexamethasone, and can prevent Adrenal cortex atrophy.Radix Rehmanniae decoct gavage can significantly reduce the ascorbic content of Rat Adrenal.As seen Radix Rehmanniae has the antagonism dexamethasone to the inhibitory action of Pituitary Adrenal cortex system, and can promote the synthetic of adrenocortical hormone.LIUWEI DIHUANG TANG has obvious blood pressure lowering, improves renal function, reduces the effect of sick mortality rate to the rat experiment renal hypertension.LIUWEI DIHUANG TANG is obviously resisted the effect that N-nitroso-group propylhomoserin second fat brings out the mice model of forestomach squamous cell cancer.

3. clinical research: Radix Rehmanniae Preparata decoct treatment hypertension, blood pressure, serum cholesterol and triglyceride all have decline, and rheoencephalogram and electrocardiogram also make moderate progress (Radix Rehmanniae Preparata is concocted with wine scientific research achievements identification book whether, 1980.6).Be 84% with the sub-rehmannia-root oral liquid treatment of compound recipe five male infertility total effective rate.

(4) Radix Salviae Miltiorrhizae:

Bitter in the mouth, little suffering, cold nature; The medicine of the heart, spleen, liver, kidney blood system; The Radix Salviae Miltiorrhizae bitter in the mouth is slightly cold, and GUIXIN, pericardium, Liver Channel have promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness effect such as calm the nerves, and can improve skin microcirculation, promote skin metabolism.Cure mainly blood stasis head, breast, the side of body, abdomen pain, gather, menoxenia, the dysmenorrhea amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, arthralgia, the traumatic injury congestive edema, epidemic febrile disease is vexed, palpitation due to deficiency of blood, sore swollen toxin, red rash scabies.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, the lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect, normal and the application of Rhizoma Chuanxiong compatibility.Belong to aspect qi depression to blood stasis in treatment breast abdomen pain, often coordinate the medicines such as Fructus Amomi, Lignum Santali Albi with using.

The effect of Radix Salviae Miltiorrhizae mainly contains:

1 〉. the effect of cardiovascular system: 1. heart tonifying is strengthened myocardial contraction, is improved cardiac function, does not increase myocardial oxygen consumption; 2. to the blood vessel function coronary artery dilating, increase myocardial flow; 3. antithrombotic forms, and improves plasmin activity, extends, clotting time, and anticoagulant (improve in platelet cAMP level suppress TXA2 synthetic) improves hemorheological properties (blood viscosity reduces, erythrocyte electrophoretic time shorten); 4. improve microcirculation.

2 〉. promote reparation and the regeneration of tissue: 1. promote the reparation and the treatment of regeneration red sage formulation of tissue: necrotic myocardium is removed fast; Fibroblast differentiation, collagen fiber form more obvious; Granulation forms comparative maturity.Local congestion alleviates, blood circulation improves, and healing time shortens.2. suppress hyperplasia the fibroblast of hyperplasia is had inhibitory action.

3 〉. protect the liver, improve microcirculation: viral hepatitis is common infectious disease of the digestive tract, and its sickness rate is high, develops into chronic rear treatment difficulty, and prognosis is relatively poor.The pathogeny that causes liver injury due to hepatitis virus is not yet fully aware of so far, therefore bring very large difficulty for the work for the treatment of hepatitis drug research.Someone estimate medicine that present countries in the world are used for treating hepatitis have more than 500 plant more than, be real radical cure but in fact also there is no so far a kind of medicine.For the medicine of seeking of ideal, in the recent decade, China has carried out a large amount of clinical experimental research work to Chinese herbal treatment hepatitis, and has obtained certain achievement.Radix Salviae Miltiorrhizae is exactly wherein to represent one of medicine.Radix Salviae Miltiorrhizae is the dried roots of Labiatae salvia (Salviamitiorrhiza Bge).Bitter in the mouth, cold nature, people's conscience two warps.Rise the seventies and begin to be used for the treatment of viral hepatitis, find it to acute, chronic active, chronic persistent, even some are with multiple Chinese and western medicine hepatitis.

4 〉. antibiotic: as to contain cryptotanshinone, dihydrotanshinone in red sage formulation, external staphylococcus, escherichia coli, degeneration bacillus are had inhibitory action.

Radix Salviae Miltiorrhizae is the Chinese medicine that is most commonly used to Acne treatment.Its main effective ingredient TANSHINONES has been made into capsule, extensive use clinically.

The main effective ingredient of tanshinone capsule is cryptotanshinone, and it has broad-spectrum antibacterial action, and propionibacterium acnes is had stronger antibacterial activity, and the gentle effect of estrogen-like antiandrogen and anti-smegma effect are still arranged.TANSHINONES treatment is comprehensive take inflammatory, abscess as main acne treatment effect, good effect, and toxic and side effects is few and light, therefore TANSHINONES be treatment take inflammatory, abscess as main acne medicine preferably, clinic is promoted.Acne intrinsic factor (as uneven in the hormone in vivo level, this moment, androgen increased relatively, caused the sebaceous gland hyperfunctioning) are arranged; Extrinsic factor is also arranged, skin nursing improper (as unsuitable cosmetics and poor environment etc.).Therefore acne standard, desirable treatment should be interior accent external controls, treating both the principal and secondary aspects of a disease.

We adopt the therapeutic scheme of 1+1+1 in the Acne treatment process, use modern biotechnology and traditional Chinese medicine to combine, reach the purpose of interior accent external control, treating both the principal and secondary aspects of a disease. as: oral skin Caring health sheet+gentle skin of clean Cuo skin Caring biotin spot printing+balance conditioning reveals full-face and embrocates, obtained good effect, safety coefficient is high, relapse rate is low, reached the treatment and the beauty treatment double effects.Concrete grammar is:

Adopt skin Caring health sheet (acne type) [Ministry of Health of the People's Republic of China's approval, authentication code: No. the 374th, hygienic food and health number [1998]] oral, this product uses modern high technology, from extraction active ingredients such as Radix Salviae Miltiorrhizae, Radix Notoginseng, Fructus Lycii, Poria, Bulbus Lilii, Radix Glycyrrhizaes, the refining Special-shaped sheet that forms, the film coating agent of employing international popular environmental protection.Have the inhibition corynebacterium acnes, balance androgen and correct the hyperkeratotic comprehensive function of follicular orifice, clinical practice more than ten years, its curative effect is sure, safety, convenience, have no side effect; Oral, one day twice, each three, after taking for two weeks, skin Caring health anti-acne root did not recur, and has the positive effect of interior accent, kept treatment about 1-3 month.

(5) Flos Lonicerae:

Flos Lonicerae has another name called Flos Lonicerae, JINHUA, Flos Lonicerae, golden rattan etc.Arrive whenever summer and autumn, mountain area, the hills of China all provinces in north and south have this climing rattan to climb plant, open the flower of HUANGBAI(sic) dichromatism, and A sweety scent assails the nostrils, and Here it is " Flos Lonicerae ".Be pure white at the beginning of when the flowers are in blossom, flavescence then, very good-looking.Gather this flower and quite be worthy of careful study, must win when fine day dew in early morning is just done, and in time dry in the sun or dry in the shade, drug effect ability is good like this.

The effect of Flos Lonicerae:

1 〉. the resisting pathogenic microbes effect: experiment in vitro shows, flower and rattan all have certain inhibitory action to various pathogens such as staphylococcus aureus, Hemolytic streptococcus, escherichia coli, dysentery bacterium, vibrio cholera, Bacillus typhi, Salmonella paratyphi etc., to streptococcus pneumoniae, meningococcus, bacillus pyocyaneus, tubercule bacillus is also effective.The water logging agent is stronger than decoct effect, and the leaf decoct is stronger than colored decoct effect.If share with Fructus Forsythiae, antibacterial range also can be complementary; Share with penicillin, can strengthen penicillin to the antibacterial action of resistant Staphylococcus aureus, this may be on anti-bacteria body internal protein is synthetic, collaborative effect to be arranged.Someone thinks that chlorogenic acid and isochlorogenic acid are the main antibiotic effective ingredients of Flos Lonicerae.

2 〉. antiinflammatory and refrigeration function: lumbar injection Flos Lonicerae extractive solution 0.25g/kg, can suppress the rat carrageenan swelling of the feet.Separately there is report honeysuckle flower injection 30-40g/kg can alleviate Ovum Gallus domesticus album swelling of the feet degree.Lumbar injection Flos Lonicerae extractive solution 8g/kg, continuous 6 days, to rat Fructus Crotonis oiliness granulation capsule, also has obvious exudation and antiproliferative effect by 2 times/days.The reporting Flos Lonicerae has obvious refrigeration function, but give family's rabbit ear vein injection with cholera vaccine, bacillus mesentericus, hay infusion etc., pyrogenicity, do not confirm that Flos Lonicerae decoct 5g/kg gavage has antipyretic effect, think that this may be different relevant with the toleration of Flos Lonicerae preparation, dosage or the rabbit of using.

3 〉. the function that strengthens the defense effect: the Flos Lonicerae decoct is diluted to the concentration of 1: 1280, still can promote leukocytic phagocytic function.Mouse peritoneal injection honeysuckle flower injection also has the effect of obvious promotion inflammatory cell phagocytic function.

4 〉. the central excitation effect: after the oral chlorogenic acid of the kinds of experiments methods such as galvanic shock, rotating cage proof, can cause that the animal central nervous system such as rat, mice are excited, its action intensity is 1/6 of caffeine, and Papillary is without addition and potentiation.

5 〉. effect for reducing blood fat: rat oral gavage Flos Lonicerae 2.5g/kg can reduce the enteral cholesterol absorption, reduces cholesterol level in blood plasma.Experiment in vitro finds that also Flos Lonicerae can combine with cholesterol, but SIMIAOYONGAN TANG (Flos Lonicerae, Radix Scrophulariae, Radix Angelicae Sinensis, Radix Glycyrrhizae) treatment Experimental Atherosclerosis in Rabbit.Do not observe the effect of blood fat reducing and Cholesterol concentration in aortic tissue content.

6 〉. antiendotoxin: measure endotoxin content with limulus test, 300% Flos Lonicerae (Radix Ophiopogonis) injection is with 1: 2-1: 64 dilutions, no matter in vitro tests uses recessed method or test tube method, all obviously reduce the endotoxin content in test solution, wherein 1: 2-1: 8 dilution tube is the same with the negative control pipe to be in a liquid state, and positive control is gel.Flos Lonicerae (Radix Ophiopogonis) distillate 6g/kg intravenous injection; the rabbit temperature decline that mutual 2.8mg/kg intravenous injection causes to the bacillus pyocyaneus endogenous toxin and leukocyte count descend antagonism; Flos Lonicerae (Radix Ophiopogonis) distillate 7.5g/kg or injection 2.5g/kg lumbar injection; mice to bacillus pyocyaneus endotoxin 65mg/kg lumbar injection has protective effect, reduces mouse death rate.

7 〉. other effect: once had the water of in-vitro screening laboratory report Flos Lonicerae and steeping in wine liquid to sarcoma 180 and ehrlich carcinoma, obvious cytotoxicity to be arranged.Flos Lonicerae extract is oral has slight preventive effect to Experimental Gastric Ulcer in Rats.The n of high dose oral chlorogenic acid can increase gastrointestinal peristalsis, promotes gastric juice and bile secretion.Chlorogenic acid and catabolite thereof have excitation to Isolated Rat Uterus.In addition, chlorogenic acid can also slightly strengthen epinephrine and norepinephrine thereof to the boosting of cat and rat, but on the nictitating membrane response of cat without impact.

(6) Fructus Gardeniae:

Another name Yellow Fructus Gardeniae, Fructus Gardeniae, white toad are the fruits of Maguireothamnus speciosus Fructus Gardeniae.At present, the fruit of Fructus Gardeniae is Chinese medicine, belong to the 1st batch of medicine-food two-purpose resource that Ministry of Public Health is promulgated, have the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, be usually used in treating the diseases such as icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice.Contain multiple iridoid glycoside constituents, be mainly gardenoside, be genipin 1-glycoside, content is up to 6%, and contains geniposide, genipin-1-β-gentiobiose glycoside, fevervine time glycoside methyl ester, gardoside, Fructus Gardeniae ketone glycoside, deacetylasperulosidic acid methyl ester etc.; Separately contain crocin, bayer acid, ursolic acid etc.

Pharmacological action:

1 〉. Fructus Gardeniae extract can increase the vigor of liver diphosphonic acid urea glycosides glucose dehydrogenase to normal rat, alleviates the hepatic injury that carbon tetrachloride causes;

2 〉. genipin, crocin and bayer acid all can make the choleresis of rat and rabbit increase; Administration in the anesthetized dog intestinal tube,, there is increase the bile output;

3 〉. mouse peritoneal injection Fructus Gardeniae alcohol extract, can reduce spontaneous activity, and with cyclobarbital, synergism be arranged;

4 〉. the flat board method that burrows proves that Fructus Gardeniae has inhibitory action to staphylococcus aureus, meningococcus, micrococcus catarrhalis etc. infusion has inhibitory action external to the various skin fungus, and kills leptospira and imago of blood fluke effect.

The effect of Fructus Gardeniae has:

1 〉. choleretic effect:

It is oral that Fructus Gardeniae aqueous extract and alcohol extract give rabbit, and the Amount of Bile that biliary pore is derived and solid composition be without impact, but have the same preparation of human to be injected in rabbit, and 15～30 minutes bile secretion begin to increase, and continue more than 1 hour.After intravenous rabbit injection crocin and crocetin sodium, choleresis increases.Fructus Gardeniae water decoction or granule or powder preparation to be taken after being infused in boiling water are done the gallbladder film making after to human oral, proves to take medicine afterwards that 20 and 40 minutes gallbladders have obvious contraction.After the total biliary pore ligation of rabbit, oral Fructus Gardeniae aqueous extract blood mesobilirubin reduces, medication the more, reduce significantly (as after ligation every 24 hours oral 1 time, result is very obvious), take especially continuously appropriate amount of drug ligation later on, income effect is best, alcohol extract also has identical effect, but than a little less than aqueous extract effect slightly.The Fructus Gardeniae alcohol extract is injected in rabbit, and blood mesobilirubin slightly increased than matched group in 2 hours, and is low than matched group after 6 hours, obviously reduces after 24～48 hours, and crocin and crocetin sodium also have same purpose.The rabbit of ductus choledochus ligation, the injection alcohol extract, tip lymph fluid mesobilirubin reduced in 24 hours, and crocin and crocetin sodium also have same purpose.Fructus Gardeniae can be used for the jaundice that biliary tract inflammation causes.

The hepatoprotective effect of the choleretic effect of laboratory observation Fructus Gardeniae extract and acute hepatic injury model mice that D-galactosamine (D-GlaN) is induced.Method: 1. cholagogic experiment: 50 rats are divided into normal group, positive group (compound dantong tablets), a large amount of group (Fructus Gardeniae extract is heavy dose of), middle amount group (dosage in Fructus Gardeniae extract), group (Fructus Gardeniae extract is low dose of) in a small amount, 10 every group.Except normal group, every day, gastric infusion, be total to 7d.Rat is row common bile duct intubation after gastric infusion 7d in advance, draws bile with conduit, in 4h every 0.5h metering bile flow.The bile of collecting detects the content of total bilirubin (TBIL), bilirubin direct (DBIL), cholesterol (TC).2. protect the liver experiment: 60 mices are divided into normal group (waiting the capacity distilled water), model group (waiting the capacity distilled water), positive group (liver-protecting tablet), a large amount of group (Fructus Gardeniae extract is heavy dose of), middle amount group (dosage in Fructus Gardeniae extract), a small amount of group (Fructus Gardeniae extract is low dose of), 10 every group.Every day is to mouse stomach 1 time, continuously 7d.1h after the last medicine, except the 1st group of quiet normal saline, other each group is all by literature method lumbar injection D-GlaN650mg/kg1 time.After 24h, the eyeground vein clump is got hematometry serum glutamic pyruvic transminase (ALT) and TBIL, gets simultaneously liver and fixes with 4% formaldehyde, does HE dyeing, carries out histopathologic examination.Result: 1. Fructus Gardeniae extract promotes the rat bile flow, and TBIL and TC excretion is increased; 2. make the active decline of model mice AIT, hepatic necrosis, hepatocellular degeneration etc. obviously changes general.Conclusion: Fructus Gardeniae extract has obvious choleretic effect and hepatoprotective effect.

2 〉. calm, hypotensive effect: white mice subcutaneous injection Fructus Gardeniae fluid extract, spontaneous activity reduced closes order, bow, of flaccid muscles, and can resist the convulsions of pentetrazole, and can not resist the convulsions of strychnine, but can reduce its mortality rate, compare with the fluid extract ash and have no above effect.Also have in order to eliminate insomnia and overtired person.Fructus Gardeniae decoct and alcohol extract are to anesthesia or not anesthetized cat, rat and rabbit, no matter oral or lumbar injection all has the persistency hypotensive effect, the intravenous injection blood pressure lowering is held time rapidly short, and its blood pressure lowering position is like at medulla oblongata parasympathetic maincenter.

3 〉. anti-microbial effect: the Fructus Gardeniae infusion the examination arm in to oidium schoenleinii, the multiple fungus such as epidermophyton inguinale, epidermophyton rubrum has inhibitory action, its water decoction 15 mg/ml can be killed leptospira, external, the Fructus Gardeniae decoct can make schistosomicide stop action, and decoct is to bacterial growth unrestraint effect.

4 〉. other effects: the Fructus Gardeniae alcohol extract is to rabbit and rat intestine in vitro smooth muscle, and low concentration is excited, and high concentration suppresses.Geniposide has discharge function to mice, and its extract is made ointment, can accelerate the healing of soft tissue.

(7) Herba Taraxaci:

Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.

The effect of Herba Taraxaci:

1, heat-clearing and toxic substances removing: can be used for pyretic toxicity card, especially kind removing heat from the liver, treatment liver-heat conjunctival congestion and swelling pain, and multi-infection, purulent disease.

2, eliminating carbuncle eliminating stagnation: the treatment pyretic toxicity is stopped up the carbuncle sore tumefacting virus tie due to the muscle, hyperpyrexia.Acute mastitis there is good effect, energy detoxicating and resolving stagnation of pathogens lactogenesis, oral administration or external application are often joined Flos Lonicerae and are equal to use.Also can join in addition Radix Et Rhizoma Rhei, Cortex Moutan treatment acute appendicitis.

The effect of Herba Taraxaci:

1, antibiotic: the 50% dull and stereotyped trench method of bright grass juice factor has inhibitory action to staphylococcus aureus, Bacillus typhi; The 50% dull and stereotyped trench method of herb decoct has inhibitory action to staphylococcus aureus and bacillus pyocyaneus.

2, antifungal: the infusion tube dilution method, 1: 4 pair of microsporon audouini is permitted blue achorion, and trichophyton etc. have inhibitory action.

3, antitumor: Herba Taraxaci hot water extract 30～40mg/kg lumbar injection, administration in 11～20 days after the subcutaneous vaccination of mice ehrlich carcinoma there is tumor-inhibiting action, invalid to administration in postvaccinal 1～10 day, the similar lentinan of its antitumor action is realized by immunologic mechanism.In addition, this product also has anti-gastric-ulcer, function of gallbladder promoting, the effect such as protects the liver.

The Herba Taraxaci purposes: 1. heat-clearing and toxic substances removing, dispersing swelling and dissipating binds cures mainly the pyretic toxicity carbuncle sore: attack conjunctival congestion pharyngeal swelling, aphtha of the mouth and tongue on a. excess-fire pyretic toxicity; B. pathopyretic ulcer, acute mastitis swells and ache, the furunculosis inside fire attack; C. lung abscess is coughed vomiting bloody pus, the abdominalgia with intestinal abscess heating.2. dampness removing: can control the puckery pain of pyretic stranguria, and jaundice caused by damp-heat.

(8) Poria:

The Poria slightly sweet flavor is flat, enters the heart, lung, spleen channel.Has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can control dysuria, the edema distension, the phlegm retention cough with dyspnea, vomiting, malignant histocytosis is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria reaches by strong activating the spleen pulmonary function, and is different from the Chinese medicine of other direct diuretic.Linggui zhugan decoction, decoction of four noble drugs, four Siberian cocklebur soup etc. are all prescriptions commonly used that the Poria compatibility is arranged; Can promote lactogenic with Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Herba Leonuri compatibility, this function is relevant with Poria tonneau water channel.

All Poria of using, its purpose are to mend not lie in and let out, and the effect of Poria is to let out and does not lie in benefit.Cover the institute of gas extremely, water also penetrates everywhere, and the institute of gas stops, and water is also more than without institute, so its water of profit is gone its gas also.Poria can mind calming the strengthening the spleen the kidney invigorating, with the tangible water of its row, the invisible gas of cloth is also; The diuretic circulation of qi promoting rises cloudyly with from sun, and the cloth sun to be changing the moon, gives birth to turbid falling in order to do clear, reaches descendingly outward, is able to tonification also and heart spleen kidney three is dirty.Poria is light and can ooze, and Gan Erneng mends, can rush down and can mend, two must its should medicine also.

Diuretic is wet with the swollen dysuria of harnessing the river, and the drink that reduces phlegm enters the disease of network to control cough, phlegm-damp, strengthening the spleen and stomach and can the antidiarrheal leukorrhagia stopping, and mind calming god controls palpitation with fear and has a sleepless night.The property of medicine is gentle, without hindering the fraud of healthy energy, can righting with it, and again can be eliminating evil, therefore insufficiency of the spleen leading to overabundance of dampness, the disease of vital QI being weakened and pathogen being violent is particularly suitable.

Generation is mended the vegetarian medical book cloud: " Poria is simply for controlling the expectorant principal agent.Expectorant this, water also, Poria can diuretic; Expectorant is moving, wets also, and Poria has feasible wet." think that its merit of reducing phlegm concerns with promoting diuresis to eliminate damp pathogen in fact, reasonable.Then the product of promoting diuresis to eliminate damp pathogen are not equal can reducing phlegm, the use of Poria, also special to some extent person.

Its chemical composition: sclerotium contains β-pachyman and accounts for dry weight 93% and triterpenoid compound Pachymic acid, pachymic acid, 3 beta-hydroxy Pilus Caprae seu Ovis steroid trienic acids; In addition, still gummy, chitin, protein, fat, sterol, lecithin, glucose, adenine, histidine, choline, β-pachyman catabolic enzyme, lipase, protease etc.

Pharmacological action:

1. diuresis Poria decoct 3 grams or clinical usual amounts there is no diuresis to Healthy People: dog intravenous injection decoct 0.048 gram/kilogram does not also make the urine amount increase, also invalid or very weak to rat, the oral decoct of rabbit (near clinical people's consumption) does not also increase the urine amount.But useful its alcohol extract is injected in the rabbit abdominal cavity, or with water extract in the rabbit chronic experiment, meaning has a diuresis, and decoct is alone or share with desoxycortone and can promote sodium excretion to the adrenalectomize rat, so the diuresis of Poria also is worth further research.Poria contains 97.5 milligrams of % of potassium, calculate with 30% water decoction, contain sodium 0.186 mg/ml, potassium 11.2 mg/ml, thus Poria promote sodium excretion with wherein contain the sodium amount irrelevant (because of sodium content too low), increase the potassium excretion relevant with its contained a large amount of potassium salt.

WULING SAN is at chronic ureteral fistula dog (intravenous injection), Healthy People and rabbit (oral decoct), Oral Administration in Rats alcohol extraction solution all shows obvious diuresis, can make sodium, potassium, chlorine discharge increase in the experiment of dog, but in WULING SAN, main diuretic is Ramulus Cinnamomi, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae.Report is also arranged, and the WULING SAN decoct is to Oral Administration in Rats, and dosage increases to 1 gram/100 grams and also fails to prove that diuresis is arranged.

2. antibacterial action does not find that in vitro Poria has bacteriostasis: ethanol extraction is external can kill leptospira, and water decoction is invalid.

3. the Poria that affects of digestive system there is direct relexation to family's rabbits infestines: the formed ulcer of rat pylorus ligation is had preventive effect, and can reduce gastric acid.

4. other effects: Poria can reduce blood glucose, and tincture, preserved material can suppress the Bufo siccus isolated heart, and ether or ethanol extraction can make the heart shrink reinforcement.

(9) Radix Angelicae Dahuricae:

Dispel the wind, dampness, detumescence, pain relieving.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.

The effect of the Radix Angelicae Dahuricae:

1, the Radix Angelicae Dahuricae has excitation to the central nervous system: angelicotoxin all has excitation to animal oblongata vasomotor center, respiratory center, vagus nerve and spinal cord in a small amount, can make increased blood pressure,

Pulse is slack-off, exaggerated respiration, and can cause the sialorrhea vomiting; Extensive application can cause tetanic intermittent cramp, general paralysis then.

2, the Radix Angelicae Dahuricae has antipyretic effect.

3, the Radix Angelicae Dahuricae has antiinflammatory, antibacterial action: the angelica anomala water decoction all has certain inhibitory action to various, and L-type tuberculosis is had significant inhibitory action.The Radix Angelicae Dahuricae has inhibitory action to funguses such as acrothesium floccosum, Gypsum Fibrosum appearance spore tinea bacterium in vitro, and water logging agent (1: 3) also has certain inhibitory action to the sub-spore tinea of Austria Du Ang Shi bacterium.

4, the Radix Angelicae Dahuricae has hypotensive activity: its contained isoimperatorin and baelfruit have hypotensive activity to cat, keep action time 1.5 hours.

5, the Radix Angelicae Dahuricae has photosensitization: the furocoumarin compounds such as its contained bergapten, xanthotoxin, isoimperatorin are " optical active substance ", can be used for treating vitiligo.

6, the Radix Angelicae Dahuricae has the effect of activation sympathetic system hormone, inhibition lipogenesis.

7, the Radix Angelicae Dahuricae has anastalsis.

8, the Radix Angelicae Dahuricae has certain effect to skin: the external of Radix Angelicae Dahuricae tincture adds low dose of UVA Radiation, and Cavia porcellus dinitrochlorobenzene contact dermatitis is had obvious inhibitory action.

9, the Radix Angelicae Dahuricae can suppress the hepatic drug metabolizing enzyme system, and the Yunnan Radix Angelicae Dahuricae has antiasthmatic effect.

(10) siritch:

1 〉. contain the unsaturated fatty acid useful to human body in siritch, and the ratio that forms is suitable, is not easy oxidation;

2 〉. especially be rich in and can enhance metabolism, improve the blood capillary circulation, bring the γ type vitamin e of skin cell nutrition, γ type vitamin is that excellent polyphenoils mass-energy prevents cell senescence effectively;

3 〉. the oleic acid composition that contains in siritch is also confirmed that the diseases such as the gastric ulcer of inhibition, asthma are arranged, prevents that skin quality from worsening, and improves the effect of immunity by medical science;

Alpha-linolenic acid in siritch again can blood fat reducing, anticoagulant, vessel softening, tonification brain, cancer, coronary heart disease, diabetes, carcinoma of prostate etc. there is the effect of prevention and treatment, so as long as we are long-term edible siritch, take precautions against fully resource just can for health, could promote the immunologic function of health, so siritch is the best health care condiment in edible oil.

Siritch sweet in the mouth, property are flat, nontoxic, and the effect of moistening dryness for relaxing bowels, nourishing blood to expel wind is arranged.Can cure the disease rear weakness, dizzy, constipation, old man's xerosis cutis, Scaling, allergic dermatitis, pruritus, skin infection eczema and hypertension, sclerosis of blood vessels, cholesterol such as increases at the disease.

The shortage of finding alpha-linolenic acid is the thing of the seventies in last century, the founder Xi Mo Prose doctor at American Genetic nutrient health center, from the omega-fatty acid that begins one's study in 1984 problem of having the balanced diet, China just began one's study in the nineties, provided the more diet style of science from nutrition and healthy angle for the mankind.The formation of omega-fatty acid theory comes from the large essential fatty acid of human body two: alpha-linolenic acid (omega-fatty acid) and linoleic acid (ω-6 fatty acid).Research finds, in the fat that human body is taken in, if the ratio of these two groups of essential fatty acid less than 1: 4, the function of human body will the most efficient, the risk that the various diseases such as cardiovascular, cancer, diabetes, obesity, arthritis, asthma are brought out in reduction.

In recent years, along with the progress of science and technology, the nutritive value of linum and health care have caused many field scientists' such as medical treatment, food, agricultural concern.A large amount of results of study show, siritch is a kind of high-quality edible oil, is rich in α one linolenic acid and various unsaturated fatty acid, can directly change into DHA and EPA in human body.Contain 55% linolenic acid in siritch, this is the highest in vegetable oil, is a kind of economical and practical " bathypelagic fish oil ".As everyone knows, " fish oil " refers to EPA and DHA, is to be become in the body of fish by alpha-linolenic acid (mainly being contained in Sargassum) in the sea.The people takes alpha-linolenic acid (mainly being contained in siritch), also can synthesize EPA and DHA in vivo.So eat the siritch that is rich in alpha-linolenic acid, just can play the effect of similar eating " fish oil "; The unsaturated fatty acid chain of restoration updating cranial nerve cell film plays brain-strengthening, nootropics, blood fat reducing, antiplatelet aggregation, expansion small artery and antithrombotic etc.

Above-mentioned formula after the science screening is compared with other formula, and is strong through taking effect property of animals and human beings body clinical experiment, successful.

Through zoopery, experiment conclusion: mice through acute toxicity LD50 greater than 21.0g/KgBW, genetoxic experiment (Ams experiment, micronucleus test, the sperm deformity experiment) result is negative, fed experiment in 30 days and find no the overt toxicity effect, according to the criterion in health food check and assessment technique standard (version in 2003) toxicological evaluation program, the food test agent improves the soft capsule of memory without overt toxicity.

Through human experimentation, experiment conclusion: the experimenter that 30 examples suffer from acne requires to take the soft capsule 30 days with acne-dispelling function, acne be improved significantly, reach clearing away heat and eliminating dampness, eliminating fire and detoxication, cooling blood for hemostasis again, enriching yin and nourishing kidney, stomach function regulating activating the spleen, also improve simultaneously the blood oxygen circulation, illustrate that the soft capsule with acne-dispelling function has the effect of the acne of dispelling.After having the soft capsule test-meal use of acne-dispelling function, routine blood test, routine urinalysis and blood biochemistry index illustrate that all in normal range this product has no adverse effects for the experimenter is healthy.

Soft capsule dose every day with acne-dispelling function is every day three times, each two.Main edible crowd is patients with acne.

The present invention compares the outstanding feature of following aspect with existing formula with acne-dispelling function: the present invention adopts the compound recipe form, meticulously select materials, rigorous prescription, pursue integral body and improve the human body situation, from the acne of dispelling, eliminating dampness and diuresis, clearing away heat-fire, cooling blood for hemostasis, the aspect across-the-board regulation healths such as balanced nutrients make the human qi and blood running unobstructed.The Radix Scutellariae eliminating fire and detoxication, arresting bleeding and miscarriage prevention; Aloe bowel relieving dampness removing; The Radix Rehmanniae Preparata nourishing YIN and supplementing blood, beneficial essence is filled out marrow; The Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, the removing heat from blood eliminating carbuncle, relieving restlessness is calmed the nerves; Flos Lonicerae has antiinflammatory and refrigeration function; Fructus Gardeniae hepatoprotective function of gallbladder promoting, hemostasia and detumescence; The Herba Taraxaci heat-clearing and toxic substances removing, the eliminating carbuncle eliminating stagnation; The Poria eliminating dampness and diuresis, invigorating the spleen and regulating the stomach; Radix Angelicae Dahuricae dispeiling pathogenic wind and removing dampness, reducing swelling and alleviating pain; The siritch vessel softening, cardioprotection; Prescription improves health, removing acne on the whole.

2, technique of the present invention is advanced, the high-grade fashion of dosage form.

The related raw material of this formula is allotment after extracting, and has dwindled volume, is convenient to produce, and is comparatively advanced.Select siritch to make solvent, strengthened the effect of this formula.Siritch contains very high unsaturated fatty acid, and linolenic acid content at 55%-60%, is natural health care, and cardiovascular system is had protective effect, also has health-care effect very widely.Can reconcile blood glucose, blood fat, blood pressure, supplementing the brain, vision protection etc.

Adopt soft capsule dosage form, can protect to greatest extent active ingredient, can be convenient to again take and digest and assimilate, the high-grade fashion of dosage form.

The most of single components such as Radix Scutellariae, Radix Rehmanniae Preparata, Herba Taraxaci, linolenic acid that adopt of the formula of the existing improvement memory relevant to the invention of this class, and the problem that this type of formula exists is that potentiation is relatively poor, and the present invention is more comprehensive, formula has increased Aloe, Radix Salviae Miltiorrhizae, Flos Lonicerae, Fructus Gardeniae, Poria, the Radix Angelicae Dahuricae, with strong complementarity, potentiation is strong.

The specific embodiment:

Most preferred embodiment shown below is described in further detail:

Feed intake and produce 1000 of 0.6g/ grain soft capsules, formed by following weight portion:

Embodiment 1, a kind of soft capsule with acne-dispelling function comprises: siritch 400 weight portions, Radix Scutellariae extract 30 weight portions, Radix Salviae Miltiorrhizae extract 10 weight portions, Radix Rehmanniae Preparata extract 20 weight portions, Poria extract 20 weight portions, Aloe extract 20 weight portions, Flos Lonicerae extract 30 weight portions, Radix Angelicae Dahuricae extract 25 weight portions, Fructus Gardeniae extract 15 weight portions, Herba Taraxaci extract 20 weight portions;

Embodiment 2, a kind of soft capsule with acne-dispelling function comprises: siritch 440 weight portions, Radix Scutellariae extract 10 weight portions, Radix Salviae Miltiorrhizae extract 10 weight portions, Radix Rehmanniae Preparata extract 10 weight portions, Poria extract 30 weight portions, Aloe extract 30 weight portions, Flos Lonicerae extract 10 weight portions, Radix Angelicae Dahuricae extract 10 weight portions, Fructus Gardeniae extract 20 weight portions, Herba Taraxaci extract 30 weight portions;

Embodiment 3, a kind of soft capsule with acne-dispelling function comprises: siritch 370 weight portions, Radix Scutellariae extract 20 weight portions, Radix Salviae Miltiorrhizae extract 30 weight portions, Radix Rehmanniae Preparata extract 30 weight portions, Poria extract 30 weight portions, Aloe extract 30 weight portions, Flos Lonicerae extract 30 weight portions, Radix Angelicae Dahuricae extract 20 weight portions, Fructus Gardeniae extract 20 weight portions, Herba Taraxaci extract 30 weight portions;

Embodiment 4, a kind of soft capsule with acne-dispelling function comprises: siritch 330 weight portions, Radix Scutellariae extract 30 weight portions, Radix Salviae Miltiorrhizae extract 30 weight portions, Radix Rehmanniae Preparata extract 30 weight portions, Poria extract 30 weight portions, Aloe extract 30 weight portions, Flos Lonicerae extract 30 weight portions, Radix Angelicae Dahuricae extract 30 weight portions, Fructus Gardeniae extract 30 weight portions, Herba Taraxaci extract 30 weight portions;

Embodiment 5, a kind of soft capsule with acne-dispelling function comprises: siritch 510 weight portions, Radix Scutellariae extract 10 weight portions, Radix Salviae Miltiorrhizae extract 10 weight portions, Radix Rehmanniae Preparata extract 10 weight portions, Poria extract 10 weight portions, Aloe extract 10 weight portions, Flos Lonicerae extract 10 weight portions, Radix Angelicae Dahuricae extract 10 weight portions, Fructus Gardeniae extract 10 weight portions, Herba Taraxaci extract 10 weight portions;

Embodiment 6, a kind of soft capsule with acne-dispelling function comprises: siritch 405 weight portions, Radix Scutellariae extract 20 weight portions, Radix Salviae Miltiorrhizae extract 15 weight portions, Radix Rehmanniae Preparata extract 30 weight portions, Poria extract 20 weight portions, Aloe extract 30 weight portions, Flos Lonicerae extract 10 weight portions, Radix Angelicae Dahuricae extract 20 weight portions, Fructus Gardeniae extract 20 weight portions, Herba Taraxaci extract 30 weight portions;

Embodiment 7, a kind of preparation method with soft capsule of acne-dispelling function.Comprise the steps:

(1) raw material preparation

Radix Scutellariae, Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Poria, Flos Lonicerae, Aloe, Fructus Gardeniae, the Radix Angelicae Dahuricae, Herba Taraxaci are carried out respectively selected, rinsing twice is drenched and to be anhydrated minute; Be 60～80 ℃ of oven dry 1.5-2 hour in temperature, making its moisture is 5-6%, after coarse pulverization granularity be 5-50mm to add water be 8 times of material, lixiviate 2-8 hour, extract 2 times; Twice filtrate merged, concentrated, be 60-80 ℃ of oven dry 1.5-2 hour in temperature, make its moisture 5-6% of being divided into; Pulverize, sieve, granularity is 0.1-0.5mm, is the Chinese medicine extract fine powder.

The selected slag of removing of flaxseed; Adopt pressafiner that selected flaxseed is squeezed; Again siritch is removed slag, add water and regulate pH value 5.5-6.5, at water temperature 55-65 ℃, fully stir, remove moisture after then precipitating two hours namely to get the refine siritch;

(2) with siritch, the extracts such as Radix Scutellariae, Aloe, Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Flos Lonicerae, Fructus Gardeniae, Herba Taraxaci, Poria, the Radix Angelicae Dahuricae mix in proportion;

(3) press 0.6g/ grain dress soft capsule after mix homogeneously;

(4) sterilization bottling, vanning;

(5) vanning warehouse-in, sale after the assay was approved.

Claims (4)

1. soft capsule with acne-dispelling function is characterized in that including the raw material of following weight portion: siritch 300-520 weight portion, Radix Scutellariae extract 10-30 weight portion, Radix Salviae Miltiorrhizae extract 10-30 weight portion, Radix Rehmanniae Preparata extract 10-30 weight portion, Poria extract 10-30 weight portion.

2. the soft capsule with acne-dispelling function as claimed in claim 1 characterized by further comprising the raw material of following weight portion: Aloe extract 10-30 weight portion, Flos Lonicerae extract 10-30 weight portion, Radix Angelicae Dahuricae extract 10-30 weight portion.

3. as claim 1 and 2 described soft capsules with acne-dispelling function, characterized by further comprising the raw material of following weight portion: Fructus Gardeniae extract 10-30 weight portion, Herba Taraxaci extract 10-30 weight portion.

4. the preparation method with soft capsule of acne-dispelling function as described in claims 1 to 3, is characterized in that, also comprises the steps:

(1) raw material preparation

Radix Scutellariae, Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Poria, Flos Lonicerae, Aloe, Fructus Gardeniae, the Radix Angelicae Dahuricae, Herba Taraxaci are carried out respectively selected, rinsing twice is drenched and to be anhydrated minute; Be 60～80 ℃ of oven dry 1.5-2 hour in temperature, making its moisture is 5-6%, after coarse pulverization granularity be 5-50mm to add water be 8 times of material, lixiviate 2-8 hour, extract 2 times; Twice filtrate merged, concentrated, be 60-80 ℃ of oven dry 1.5-2 hour in temperature, make its moisture 5-6% of being divided into; Pulverize, sieve, granularity is 0.1-0.5mm, is the Chinese medicine extract fine powder.

The selected slag of removing of flaxseed; Adopt pressafiner that selected flaxseed is squeezed; Again siritch is removed slag, add water and regulate pH value 5.5-6.5, at water temperature 55-65 ℃, fully stir, remove moisture after then precipitating two hours namely to get the refine siritch;

(2) with siritch, the extracts such as Radix Scutellariae, Aloe, Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Flos Lonicerae, Fructus Gardeniae, Herba Taraxaci, Poria, the Radix Angelicae Dahuricae mix in proportion;

(3) press 0.6g/ grain dress soft capsule after mix homogeneously.