CN106237131A

CN106237131A - The Herba Taraxaci oral liquor of lowering blood-fat and reducing weight and oral liquid thereof

Info

Publication number: CN106237131A
Application number: CN201610629192.1A
Authority: CN
Inventors: 马佳
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-08-02
Filing date: 2016-08-02
Publication date: 2016-12-21

Abstract

The invention discloses the preparation method of the Herba Taraxaci oral liquid of a kind of lowering blood-fat and reducing weight, in described step c, by 2-in-1 to component 1 and component and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.36, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 0.1g；Unguentum after concentration adds Mel or dextrin is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.The present invention is experimentally confirmed, and can promote lipid metabolism and decomposition, maintains normal physiological function, overcome for diet products destruction dietaries such as food type, excretion pattern, nerve suppressive, reduce function of human body, and induce the shortcoming of Other diseases, it is good lowering blood-fat and reducing weight product.

Description

The Herba Taraxaci oral liquor of lowering blood-fat and reducing weight and oral liquid thereof

Technical field

The present invention relates to containing the medical health product deriving from plant, animal or raw mineral materials, particularly to a kind of blood fat reducing Herba Taraxaci oral liquid of fat-reducing and preparation method thereof.

Background technology

Due to economical day by day flourishing, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, no Notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, keen competition Operating pressure, the physical and mental health of modern is caused serious threat, makes people more than half be in sub-health state, table Being now: dizzy, nervous, weak, inappetence, hypomnesis, insomnia, indifferent to etc. to thing, in addition, long-term diet does not conforms to Reason, it may be assumed that essence grain replaces coarse grain completely, substantial amounts of three-hypers (high heat, high protein, higher fatty acid), more than three (preservative is many, flavour enhancer is many, Hormone is many) pesticide of residual, chemical fertilizer stockpiling in vivo in the absorption of food and food, add air, pollution of waterhead and fortune Momentum is less than normal, goes down to make the what is called such as three-hypers disease (hypertension, hyperglycemia, hyperlipidemia), cardiovascular and cerebrovascular disease, cancer for a long time " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.

When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, internal lipase activity is to subtract Low, therefore easily blood fat increases.On the other hand diabetes itself the most also accompany in addition to carbohydrate metabolism disturbance fat, protein and Water, dielectric disorder.Often there is free fatty to mobilize out from fat depot, make triglyceride and free fatty in blood Concentration increases.Another further aspect type 2 diabetes mellitus people takes food too much, and motion is few, promotes the synthesis of internal lipid to increase, and this is also to cause blood The reason that fat increases.And obesity companion hyperlipidemia person, owing to Insulin receptor INSR number reduces relatively, thus produce insulin resistant, easily Induced Diabetic.Diabetes are due to insulin secretion, insulin action or both simultaneously carbon aquations caused by existing defects A kind of syndrome of compound, protein and fat metabolic disturbance.Basic feature is that blood glucose increases, and long-term damage is various organ Dysfunction and exhaustion, including the vascular conditions being constantly in progress, i.e. retinopathy, blind, nephropathy, renal failure, god Foot ulcers, amputation and autonomic nervous function is accompanied to change through pathological changes, the most ever-increasing cardiovascular, cerebrovascular and peripheral vessels The danger of pathological changes.

Dandelion herb, rich in vitamin A, vitamin C and potassium, also contains ferrum, calcium, vitamin B2, vitamin B1, magnesium, dimension life Element B6, folic acid and copper.Concrete constituent content is mainly moisture, every 60 grams of dandelion herb leaf moisture contents 86%, protein 1.6 Gram, carbohydrate 5.3 grams, heat there are about 108.8 kilojoules.Containing taraxol, taraxacin, gallbladder in Herba Taraxaci plant The multiple health-nutrition compositions such as alkali, organic acid, inulin.Nature and flavor are sweet, micro-hardship, cold.Return liver, stomach warp.Have diuresis, cathartic, jaundice eliminating subcutaneous ulcer, The effects such as function of gallbladder promoting.Control pyretic toxicity, carbuncle, skin infection, abscess of internal organ, conjunctival congestion and swelling pain, damp and hot, the puckery pain of jaundice, dribbling urination, furuncle swelling toxin, breast Carbuncle, scrofula, toothache, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Control acute mastitis, lymphadenitis, scrofula Scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urine Road feel dye etc..Herba Taraxaci is raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.

Herba Taraxaci lowering blood-fat and reducing weight, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctiva Inflammation, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Tang Materia Medica: housewife Human milk carbuncle." Bencao Tujing ": apply skin ulcer, controls again evil thorn and contact dermatitis." Amplification on Materia Medica addendum ": heat-transformation poison, the swollen tuberculosis of the evil that disappears, solve Food poison, dissipates stagnant gas." the southern regions of the Yunnan Province book on Chinese herbal medicine ": apply all pyogenic infections from tumour or sore, mange tinea skin ulcer；Dispeling the wind, disappear all sores, dissipates scrofula tuberculosis；Stop the least having blood in stool, Control the five types of stranguria difficulty in urination, profit bladder." detailed outline ": crow beard and hair, strengthening bone and muscle." Bencao Jingshu ": Herba Taraxaci is hidden sweet flat, and its property is nontoxic.When being Enter liver and enter stomach, the key medicine of antipyretic removing heat from blood.Acute mastitis belongs to Liver Channel, and married woman is after row, and Liver Channel is taken charge, therefore housewife's human milk carbuncle breast is malicious, and Preferably give birth to warm good." book on Chinese herbal medicine is stated ": Herba Taraxaci, bitter more than Gan Erwei, it is Gan Ping and has the person of being slightly cold concurrently also.Uncommon harmony has to be said: sweet flat agent The bright Liver and kidney of point.' hide this language, then know its enter stomach and double enter Liver and kidney, not so, how removing heat from blood, crow beard and hair, with the blood appointed together in punching Dirty？I.e. think of, then east wall what is called kidney channel must user, especially when in the same way, improper only before cured mainly use up also." book on Chinese herbal medicine Newly organized ": Herba Taraxaci, to the low-pricedest and have big merit, do not know to use it by means of common people.The fire that sun is bright, often to setting a prairie fire, with Baihu Tang with pathogenic fire purging, not Exempt to injure one's stomach very much gas.Fire in lid stomach is contained, owing to stomach sergeant declines also, pathogenic fire purging and soil more declines.Therefore to rush down stomach-fire, be one with tiger soup certainly Time extremely suitable, and can not rely on for prolonged also.Herba Taraxaci also rushes down the medicine of stomach-fire, but its gas is the most flat, can pathogenic fire purging, the most do not damage soil, Clothes clothes for a long time can be grown and do not hinder.Fire the person that all systems sun is bright, all agent greatly can take it, and fire moves back and gastric qi is spontaneous.But the power of its pathogenic fire purging Little, it is necessary to multiplex, one or two, few also five, six money, begin to dissipate evil auxiliary positive ear.Or ask, Herba Taraxaci pathogenic fire purging, the fire that antidiarrheal sun is bright, no Know the fire of each warp, also can disappear to the greatest extent？Saying, the strongest person of fire, nothing crosses the flame that sun is bright, the fire fall that sun is bright, and through ember the most invariably Disappear to the greatest extent.Though the medicine of the non-each warp of Herba Taraxaci, and the fire of each warp, see Herba Taraxaci and most volt, i.e. call Herba Taraxaci and can disappear the fire of each warp, also without Can not be also.Or ask, Herba Taraxaci and Flos Lonicerae, it is both the thing of eliminating carbuncle infections, two things who victory after all？Husband's Herba Taraxaci stops into sun bright, too Cloudy two warps, Flos Lonicerae is not then without through entering, and Herba Taraxaci can not be same as function also with Flos Lonicerae.So Flos Lonicerae obtains Herba Taraxaci and its merit Bigger.

Herba Taraxaci herb contains taraxasterol, choline, inulin, pectin etc..In root containing taraxol, taraxerol, ψ- Portugal's Herba Taraxaci sterol, taraxasterol, β-Amyrin, stigmasterol, cupreol, choline, organic acid, fructose, sucrose, Fructus Vitis viniferae Sugar, glycoside and resin, rubber etc..Leaf containing phylloxanthin, violaxanthin, phylloquinone, vitamin C (50～70 milligrams/ 100 grams) and vitamin D (5～9 milligrams/100 grams).

Containing arnica montana glycol, phylloxanthin and flavoxanthin in spending.In pollen containing cupreol, 5z-bean steroid-7-alkene-3 β- Alcohol, folic acid and vitamin C.Containing phylloquinone in green calyx.Containing cupreol and β-Amyrin in scape.These product are advanced in years containing examining again This torr alcohol, the micro-gram gram of riboflavin 1.43 and carotene 7.7～8.8 milligrams of %.

(1) antibacterial action: in this product injection test tube, staphylococcus aureus resistance bacterial strain, Hemolytic streptococcus are had Stronger bactericidal action.To Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, dysentery bacterium, Bacillus typhi etc. And micrococcus catarrhalis also has certain bactericidal action.This product alcohol extract 1:400 can suppress tulase, but decoct 1:100 is invalid.Its 1:80 Water decoction ECHO11 viral cytopathic, ethanol extract (31mg/kg) can be delayed leptospira to be killed, to some fungus also There is inhibitory action.Campylobacter pylori is had good killing action.

(2) lactogenesis: this product leaf has the obstruction of dredging breast vascular, promotes the effect of lactogenic.

(3) antitumor action: the polysaccharide (Tof mono-CFr) extracted in common dandelion, with 40,2,600mg/kg ip awards The C3H mouse of inoculation MM46 tumor cell, early stage is administered the effect that has no, but is administered the next day of the later stage of 11～20 days and 2～20 days The most effective.Tumor cell is delayed type anaphylaxis (T mono-DHR), at ddy mono-Ehrlich (same tumor) is and C3H mono- During MM46 (syngeneic tumor) is, the Tof mono-CFr later stage is administered its footpad reaction and the most substantially rises compared with matched group.In ADMC system In, Tof mono-CFr, compared with the glycogen being known to activated macrophage, has higher activation capability

(4) choleretic effect: foreign study, these product have choleretic effect, clinical treatment chronic gallbladder spasmolytic and calculosis to have Effect.The effects such as this product still has diuresis stomach invigorating in addition, hypocatharsis.

Being three points of poison of medicine, Chinese medicine health care product must control dosage well so that it is toxicity is preferably minimized.The present invention greatly improves Chinese medicine extraction technology so that the toxic component of Chinese medicine is preferably minimized, can make absorption of human body, is greatly improved its utilization rate.Control Dosage；Strengthen " dose-effect relationship " and " amount poison relation " research；Use modern technologies, inside and outside method combining assessment.

Summary of the invention

The technical problem to be solved is, the technical problem to be solved is, the most on the market The various health product sold, dragons and fishes jumbled together for medicine, the amusement of great majority simply false propagandas, and have does not only have health-care components, Also resulting in the huge injury of the person, therefore, search of health effective vessel softening method has the most real significance, peace Complete effective vessel softening active substance is always people and expects the key of solution problem.Chinese medicine hypoglycemic is lost weight, and has nothing Poison, the advantage that can be fully absorbed by organism, be our Main way of studying.The present invention greatly improves Chinese medicine extraction technology, The toxic component making Chinese medicine is preferably minimized, and can make absorption of human body, is greatly improved its utilization rate.

For solving above-mentioned technical problem, the present invention provides the Herba Taraxaci oral liquid of a kind of lowering blood-fat and reducing weight, its described oral liquid The crude drug of following parts by weight can be included: Herba Taraxaci 10～50 parts, Caulis Spatholobi 10～20 parts, Herba Rabdosiae Lophanthoidis 10～20 parts, summer Hay 10～20 parts, Fructus Mori 10～20 parts, the Radix Paeoniae Alba 10～20 parts, Radix Angelicae Sinensis 10～20 parts, Herba Euphrasiae Regelii 10～20 parts, Rhizoma Imperatae 10～ 20 parts, Fructus Ligustri Lucidi 10～20 parts, Calyx Hibisci Sabdariffae 10～20 parts, Flos Lonicerae 10～20 parts, Flos Albiziae 10～20 parts, Semen Cuscutae 10～20 Part, Herba Ecliptae 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Fructus Atriplicis Sibiricae 10～20 parts, Fructus Gardeniae 10～20 parts, the Radix Rehmanniae 10～20 parts.

The Herba Taraxaci oral liquid of described lowering blood-fat and reducing weight, in its described oral liquid, the parts by weight of various crude drug are all right For: Herba Taraxaci 10～30 parts, Caulis Spatholobi 10～15 parts, Herba Rabdosiae Lophanthoidis 10～15 parts, Spica Prunellae 10～15 parts, Fructus Mori 10～15 parts, The Radix Paeoniae Alba 10～15 parts, Radix Angelicae Sinensis 10～15 parts, Herba Euphrasiae Regelii 10～15 parts, Rhizoma Imperatae 10～15 parts, Fructus Ligustri Lucidi 10～15 parts, Calyx Hibisci Sabdariffae 10～15 parts, Flos Lonicerae 10～20 parts, Flos Albiziae 10～20 parts, Semen Cuscutae 10～20 parts, Herba Ecliptae 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Fructus Atriplicis Sibiricae 10～20 parts, Fructus Gardeniae 10～20 parts, the Radix Rehmanniae 10～20 parts.

The Herba Taraxaci oral liquid of described lowering blood-fat and reducing weight, in its described oral liquid, the parts by weight of various crude drug can also For: Herba Taraxaci 10～40 parts, Caulis Spatholobi 10～20 parts, Herba Rabdosiae Lophanthoidis 10～20 parts, Spica Prunellae 10～20 parts, Fructus Mori 10～20 parts, The Radix Paeoniae Alba 10～20 parts, Radix Angelicae Sinensis 10～20 parts, Herba Euphrasiae Regelii 10～20 parts, Rhizoma Imperatae 10～20 parts, Fructus Ligustri Lucidi 10～20 parts, Calyx Hibisci Sabdariffae 10～20 parts, Flos Lonicerae 10～15 parts, Flos Albiziae 10～15 parts, Semen Cuscutae 10～15 parts, Herba Ecliptae 10～15 parts, Radix Polygoni Multiflori Preparata 10 ～15 parts, Fructus Atriplicis Sibiricae 10～15 parts, Fructus Gardeniae 10～15 parts, the Radix Rehmanniae 10～15 parts.

For solving above-mentioned technical problem, the present invention also provides for the preparation method of the Herba Taraxaci oral liquid of a kind of lowering blood-fat and reducing weight, The preparation process of its described oral liquid includes:

A. the preparation of Herba Taraxaci, as component 1；

B. remaining crude drug described is put into heating and refluxing extraction 2 times in ethanol, as component 2；

C. by 2-in-1 also to above two extracting solution component 1 and component, add Mel after concentration or dextrin is in harmonious proportion, after disinfection It is prepared as oral liquid bottling.

In described step a, Herba Taraxaci can be plucked, after clean dry, be soaked in the ethanol accounting for its quality 10 times amount 1-2 hour, being then placed in extraction pot heating extraction 2 times, each 1-2 hour, take supernatant, united extraction liquid, 100-120 mesh is filtered Cross, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 Extractum, heating is concentrated into paste, stand for standby use, becomes component 1 standby.

In described step b, remaining raw material described can be steeped and account in its quality 10 times amount ethanol, heating extraction 2 times, often Secondary 1-2 hour, taking supernatant, united extraction liquid, 100-120 mesh filters, then the ultrafiltration that molecular weight is 5000-10000 through damming Post ultrafiltration, the extractum of 1.06 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heat and be concentrated into paste, stand for standby use, in groups Divide 2.

In described step c, can by 2-in-1 to component 1 and component and after, insert in economic benefits and social benefits vacuum concentrator, be concentrated into 90 DEG C Time relative density be the concentrated solution of 1.36, set to 0～5 DEG C of deepfreezes 24 hours；The filter aid diatom that cold preservation liquid is added 0.3% Soil, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 0.1g；Unguentum after concentration adds Mel Or dextrin is in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.

For solving above-mentioned technical problem, the present invention also provides for the preparation method of the Herba Taraxaci oral liquid of a kind of lowering blood-fat and reducing weight, Preparation process can also be:

A. by Herba Taraxaci extracting in water, as component 1；

B. after being extracted by Herba Taraxaci, residue is soaked together with remaining crude drug described, is extracted 2 times as component 2；

C. add Mel after component 1, component 2 being mixed concentration to be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.

In described step a, the Herba Taraxaci plucked can be cleaned, put into extraction pot heating extraction after dry in the sun 2 times, every time 1-2 hour, taking supernatant, united extraction liquid, 100-120 mesh filters, then the ultrafiltration post that molecular weight is 5000-10000 through damming Ultrafiltration, the extractum of 1.06 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 1；In described step b, can will carry The Herba Taraxaci dregs taken are put into together with remaining raw material described and are accounted in its quality 5-10 times amount water, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, taking supernatant, united extraction liquid, 100-120 mesh filters, and is merged by 2 extracting solution and stands, and decompression is also Being concentrated into liquor strength is 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08；It is decompressed to 0.03- 0.08MPa, temperature is maintained at 60-80 DEG C, and being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, as component 2。

In described step c, after component 1 can be mixed, put into concentrating under reduced pressure tank with component 2, decompression recycling ethanol is dense Being reduced to liquor strength is 0.1g crude drug/mL, when the relative density of sucking filtration to filtrate is 20 DEG C 1.06；Above-mentioned filtrate through volume is After the macroporous adsorptive resins absorption of 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then with 5 times of resins 95% ethanol elution of column volume, collects ethanol elution, removes solvent, then is in harmonious proportion Mel, bottles after ultraviolet ray sterilization bactericidal.

Medical verification, Herba Taraxaci can have an antiobesity action with blood fat reducing, clears up the intestines and stomach, eliminating toxin and beautifying the skin, liver nourishing lung moistening, this Bright pass through function assessment and toxicological experiment proves, lipid metabolism and decomposition can have been promoted, maintain normal physiological function, overcome For diet products destruction dietaries such as food type, excretion pattern, nerve suppressive, reduce function of human body, and induce Other diseases Shortcoming, therefore the present invention is favored by three-hypers crowd.The micro-bitter glycol of the present invention；Add some blood circulation promoting and blood stasis dispelling, to fat and Serum triglycerides all has the Chinese crude drug of obvious reduction effect, and can improve microcirculation, makes people be prone to accept, reaches daily health caring Function, more can preferably reach hypoglycemic fat-reducing effect.Present invention demonstrates that Herba Taraxaci lowering blood-fat and reducing weight, diuresis eliminating stagnation, use In hepatobiliary disease, truly have significant curative effect for low icterus index, the shortening course of disease, mitigation symptoms and recovery liver function.

Detailed description of the invention

Along with industrialized development, the change of dietary structure, the improvement of living condition, overweight and obese people quantity exists Increase rapidly in world wide, and in the trend of becoming younger, become the global epidemic diseases having a strong impact on health, therefore, find strong The effective method of weight-reducing of health has a most real significance, and safely and effectively anti-obesity activity material is always people and expects to solve The key of problem of obesity.Hypoglycemic method is a lot, has dietetic therapy, exercise therapy, pharmacotherapy and clinical treatment etc. these Method more or less has weak point, and have the most easily causes side effect, such as diarrhoea, anorexia etc..And health product fat-reducing has Easy to use, have no side effect, the features such as effect is notable, and the most popular with consumers.

Method of weight-reducing more than subtracting 10 January jin is innumerable.Maximally effective method of weight-reducing, is not that this moon, you deducted 10 jin, 20 jin, 30 jin of body weight, but current fat-reducing you are thin gets off, you do not rebound, and you subtract more healthy and more healthy, otherwise cut How much all deceive oneself as well as others.A fat-reducing simply process relatively having the time limit, and control body weight all one's life through people, then add On cause obesity reason be many, such as: the age of overweight people, sex, with chronic disease, health, life The many difference that exists many-sided with dietary habit, inherited genetic factors etc., so fat-reducing is not simple thing, not only a Yao You section The method learned, certain willpower, with greater need for the guidance and help of professional person, if paying no attention to anti-obesity mechanism, pay no attention to own situation, and one The blindness of taste is followed the wind, and is tantamount to body reagent, and trying right that by chance is fortune, and unfortunate fortune will not bring everyone, more Time, what the method for weight-reducing of mistake was brought can only be the result of mistake.So how we should subtract？Find out self fat Root, suits the remedy to the case.Having lipodystrophy, good, we are supplied to its sufficient nutrition, activate it, subtracting the most simply Few diet heat or eat appetrol, only can make this obstacle make the matter worse, your not oil supply of machine, and light is want to rotate it by external force, knot Fruit is well imagined, the cell of people is too.Of excessive eating and drinking, absorption heat is too high, good, and the diet that we must draw oneself up has Eating of restraining, selectively eats, has eating of time rather than suffering from hunger simply.

Herba Taraxaci lowering blood-fat and reducing weight, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctiva Inflammation, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Tang Materia Medica: housewife Human milk carbuncle." Bencao Tujing ": apply skin ulcer, controls again evil thorn and contact dermatitis." Amplification on Materia Medica addendum ": heat-transformation poison, the swollen tuberculosis of the evil that disappears, solve Food poison, dissipates stagnant gas." detailed outline ": crow beard and hair, strengthening bone and muscle." Bencao Jingshu ": Herba Taraxaci is hidden sweet flat, and its property is nontoxic.When being to enter into liver Stomach, the key medicine of antipyretic removing heat from blood.Acute mastitis belongs to Liver Channel, and married woman is after row, and Liver Channel is taken charge, therefore housewife's human milk carbuncle breast is malicious, and preferably gives birth to warm Good." book on Chinese herbal medicine is stated ": Herba Taraxaci, bitter more than Gan Erwei, it is Gan Ping and has the person of being slightly cold concurrently also.Uncommon harmony has to be said: the sweet flat agent bright liver of point Kidney.' hide this language, then know its enter stomach and double enter Liver and kidney, not so, how removing heat from blood, crow beard and hair, dirty with the blood appointed together in punching？ I.e. think of, then east wall what is called kidney channel must user, especially when in the same way, improper only before cured mainly use up also." book on Chinese herbal medicine is newly organized ": Herba Taraxaci, to the low-pricedest and have big merit, does not knows to use it by means of common people.The fire that sun is bright, often to setting a prairie fire, with Baihu Tang with pathogenic fire purging, hinders rather Gastric qi.Fire in lid stomach is contained, owing to stomach sergeant declines also, pathogenic fire purging and soil more declines.Therefore to rush down stomach-fire, be the pole in a period of time with tiger soup certainly Preferably, can not rely on for prolonged also.Herba Taraxaci also rushes down the medicine of stomach-fire, but its gas is the most flat, can pathogenic fire purging, the most do not damage soil, Ke Yichang Clothes take for a long time and do not hinder.Fire the person that all systems sun is bright, all agent greatly can take it, and fire moves back and gastric qi is spontaneous.But the power of its pathogenic fire purging is little, must Must be multiplex, one or two, few also five, six money, begin to dissipate evil auxiliary positive ear.Or ask, Herba Taraxaci pathogenic fire purging that each warp failed to see by the fire that antidiarrheal sun is bright Fire, also can disappear to the greatest extent？Saying, the strongest person of fire, nothing crosses the flame that sun is bright, the fire fall that sun is bright, and respectively through ember without disappearing not to the utmost.Pu Though the medicine of the non-each warp of Herba Taraxaci, and the fire of each warp, see Herba Taraxaci and most volt, i.e. call Herba Taraxaci and can disappear the fire of each warp, also without can not be also.

Spica Prunellae has the effect of improving eyesight of relieving inflammation or internal heat, and can control conjunctival congestion and swelling pain, headache etc..This product decoct, water-leach liquor, alcohol-water Leachate and alcohol leaching liquid all can obviously reduce laboratory animal blood pressure, and stem, leaf, fringe and herb all have a hypotensive effect, but fringe Act on more apparent；This product water decoction-alcohol sedimentation liquid mouse peritoneal is injected, and has obvious antiinflammatory action；This product decoct is in vitro to dysentery bar Bacterium, Bacillus typhi, vibrio cholera, escherichia coli, Bacillus proteus, staphylococcus and Bacillus tuberculosis all have certain suppression to make With.Spica Prunellae compatibility Radix Angelicae Sinensis, Radix Paeoniae Alba Spica Prunellae liver heat removing scattered silt；Radix Angelicae Sinensis, the Radix Paeoniae Alba nourish blood and enrich blood. and three 5 is with having solution stagnation of liver-QI, nourishing the liver Effect of blood is used for treating all diseases caused by hepatic depression and blood deficiency. Spica Prunellae compatibility Flos Chrysanthemi Spica Prunellae clearing away liver-fire, suppressing the hyperactive liver sun；Flos Chrysanthemi heat clearing away is cool Liver. Papillary have liver heat removing, cool liver, suppressing the hyperactive liver merit for treating flaming up of liver-fire, wind-heat of liver channel causes conjunctival congestion and swelling pain；Or on liver-yang High cause headache, dizziness.

The Radix Paeoniae Alba is bitter, is slightly cold.Return Liver Channel.Attending effectiveness: clearing away heat and cooling blood；Blood circulation promoting and blood stasis dispelling.Main maculae caused by violent heat pathogen；Hematemesis and epistaxis；Intestinal Wind hematochezia；Conjunctival congestion and swelling pain；Carbuncle skin infection；Amenorrhea；Dysmenorrhea；Metrorrhagia and leukorrhagia stranguria with turbid discharge；The stagnant hypochondriac pain of the stasis of blood；Hernia abdominal mass is gathered；Injury from falling down.For temperature Poison sends out speckle, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection." herbal classic ": Main pathogen is suffered from abdominal pain, and except arthralgia due to stagnation of blood, broken heavily fortified point is long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." not Lu ": clear and coherent blood vessels, slow in, dissipate and dislike Blood, expelling extravasated blood, go aqueous vapor, profit bladder intestine and small intestine, subduing inflammation, time row cold and heat, attacked by pestiferous factors suffers from abdominal pain, lumbago." property of medicine opinion ": control pathogen of the lung Gas, abdominal pain, vim and vigour are gathered, and lead to a surname's internal organs and gather around gas, control evil pain deteriorated blood, and time main, disease bone heat, strong the five internal organs, the kidney invigorating gas, control trusted subordinate Hard swollen, married woman's blood closes obstructed, repercussive blood, can lose pus.

Herba Ecliptae Compositae, annual herb plant.Uprightly, tool stolon；Leaf is to life, lanceolar；Head inflorescence, axil raw or Top is raw, floral white；Achene black.Whole nation dispersed species.It is common in field stalk, Gou Xi limit wetland.Herb is medicinal, can restrain, stops blooding, mend Effect of Liver and kidney.The diseases such as nourishing the liver and kidney, cooling blood for hemostasis, can control various haematemesis, enterorrhagia.Smash juice painting eyebrow to send out, can promote that hair is raw Long, for oral administration have black hair, hair color effect.Tang Materia Medica is said, Herba Ecliptae " main dysentery, acupuncture skin ulcer sends out, flood blood can not the person of stopping respect it " " day China's son book on Chinese herbal medicine " in also say, Herba Ecliptae can " evacuation of pus, hemostasis, logical small intestinal, apply all skin ulcers silkworm ".

Radix Angelicae Sinensis, its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, invigorating middle warmer has, has benefit, really in row Gas medicine in blood, the also panacea in blood.About then the mending to mend of assistant, therefore can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, Benefit mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, thus can dispel pain relieving constipation, relieving rigidity of muscles and joints, control contracture, paralysis, The card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant, with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, can dissipate greatly Biao Weire, and person do not held back by table, help with Radix Et Rhizoma Rhei Etc, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore it is intended to its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidates person when keeping away it.In all the moon Fire Sheng person, the active blood of Radix Angelicae Sinensis, the most non-preferably, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata point, direct slicing is used as medicine for Radix Polygoni Multiflori, after mixing steaming with Semen sojae atricolor liquor Dry and be used as medicine for Radix Polygoni Multiflori Preparata.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation, is usually used in treating scrofula Scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation；Radix Polygoni Multiflori Preparata function invigorating the liver and kidney, benefiting essence-blood, crow beard and hair, bone and muscle strengthening, for blood deficiency and yellow complexion, Vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body are empty.Radix Polygoni Multiflori Preparata of the present invention It it is the good merchantable brand of invigrating kidney.

The Radix Rehmanniae: the Radix Rehmanniae is also Radix Rehmanniae, Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch. fresh or dry tuber.Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, cool Blood, hemostasis；The effect of Radix Rehmanniae and Radix Rehmanniae is different.Radix Rehmanniae clearing away heat and promoting production of body fluid, can stop blooding and removing heat from blood, often For diseases such as consumption of YIN caused by febrile disease, haematemesis, laryngopharynx swelling and pain, crimson tongue excessive thirst, a speckle dermexanthesis and nosebleed heat.Relative to Radix Rehmanniae, the Radix Rehmanniae Huang is heat clearing and blood cooling, it is also possible to promote the production of body fluid, it is also possible to yin nourishing, is used for treating yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, crimson tongue excessive thirst, sending out speckle The problems such as dermexanthesis.The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.Not only promoting the production of body fluid to quench thirst and heat clearing and blood cooling, also to metrorrhagia, menoxenia, Frequent fetal movement, constipation etc. have effect, every blood system to have the people that thermal burn is cloudy, can often take.If it is intended to treatment epidemic febrile disease, Qingying decoction can be done with the Radix Rehmanniae；If the later stage for the treatment of epidemic febrile disease, do not disappear to the greatest extent due to waste heat, it should the Radix Rehmanniae is used for boiling Herba Artemisiae Annuae Turtle shell soup；It addition, contain for heat in blood poison, macule purple is black, and epidemic febrile disease seriously heat enters the symptom of nutrient blood, can take what the Radix Rehmanniae was made Sisheng Wan；Typically want YIN nourishing and the production of body fluid promoting to treat interior-heat to quench one's thirst and constipation, it should the once liquid soup that the edible Radix Rehmanniae boils.

Fructus Gardeniae bitter cold, can blood system and clear pathogen is warm, wide intestinal relieving constipation, anti-cancer, Flos Gardeniae contains cellulose, can prevent hemorrhoid Make and the generation of rectum carcinoma.Radix Gardeniae, leaf, fruit all can be used as medicine, and have pathogenic fire purging relieving restlessness, and antiinflammatory is dispelled heat, clearing away heat and promoting diuresis, external Effect of removing toxic substances.Flos Gardeniae, fruit, leaf and Gen Ke are used as medicine, and typically make tea or decoct soup clothes.Fructus Gardeniae containing gardenoside, geniposide, Herba Paederiae time glycoside methyl ester and a small amount of shanzhiside, have that clearing away heat and promoting diuresis, external removing toxic substances, jaundice, stranguria with blood pain be the most puckery, the red and swollen pain of mesh, fire-toxin skin ulcer, The effects such as blood pressure lowering.Wherein fruit of Fructus Gardeniae is used as medicine, and cures mainly calentura hyperpyrexia, dysphoria and insomnia, and excess-fire is had a toothache, aphtha of the mouth and tongue, and nose is advised, told Blood, eye conjunctivitis, sore swollen toxin, icteric infectious hepatitis, favism, hematuria；Traumatic hemorrhage, bruise are controlled in external.Root enters Medicine cures mainly infectious hepatitis, traumatic injury, acute toothache.Compendium of Material Medica claims it, and " improving healthy complexion, it is used by " a thousand pieces of gold wing " face cream.” " the southern regions of the Yunnan Province book on Chinese herbal medicine " claims its " purte the white, only cough due to lung-heat, only epistaxis blood, expectorant." meridian distribution of property and flavor: cold in nature, sweet-bitter flavor；Enter lung, liver Warp.Effect: clearing away lung-heat to relieve cough, external is stopped blooding.Cure mainly cough due to lung-heat, nose, cough up phlegm, the disease such as toxic swelling.Main component: Flos Gardeniae Containing Triterpenoid, Fructus Gardeniae flower acid A, B and son acid.Containing volatile oil, including benzyl acetate, linalyl acetate, another containing pigment glycoside, wood Honey alcohol etc..It addition, possibly together with carbohydrate, protein, crude fibre and multivitamin.

Fructus Mori Chinese medicine thinks Fructus Mori sour in the mouth, cold nature, has raising body immunity, YIN nourishing of enriching blood, promotes the production of body fluid Quench the thirst, the effect such as dry is dispelled in intestine moistening, cure mainly deficiency of YIN-blood and cause have a dizzy spell, tinnitus cardiopalmus, irritated insomnia, soreness of the waist and knees, palpus Send out early white, quench one's thirst only dry, constipation with dry stool, nourishing YIN and supplementing blood, improving eyesight calm the nerves, profit joint, curing rheumatism, the effect such as relieve the effect of alcohol.Anti-hemostatic tube Hardening: containing fatty acid in Fructus Mori, mainly by linoleic acid.Stearic acid and oleic acid composition, have and reduce fat, and reduces blood fat, anti- Hemostatic tube hardening etc. act on.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, numbness Paralysis, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation；Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot；Quadriplegia；Rheumatism numbness Bitterly；Women has through uncomfortable；Dysmenorrhea.External is gynecological's good medicine of activating blood circulation to dissipate blood stasis.

Fructus Ligustri Lucidi, is the Chinese medicine of replenishing kidney-YIN, nourishing the liver to improve visual acuity simply, can treating the liver kidney deficiency, dizzy ear toot, early whitening of hair and The disease meridian distribution of property and flavor such as two blurred vision pastes: sweet, bitter, cold.Return liver, kidney channel.Effect: liver and kidney tonifying, improving eyesight, clearind deficient heat.Cure mainly: dizzy Dizzy, early whitening of beard and hair, blurring of vision, fever due to yin deficiency.For the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, the soreness of waist Tinnitus and fever due to yin deficiency etc..This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly take effect.Control poor vision, often join Radix Rehmanniae Preparata, Tu SIZI, Fructus Lycii equivalent use, control early whitening of beard and hair, often join Herba Ecliptae, Fructus Mori equivalent use, control fever due to yin deficiency, often join Cortex Lycii, Radix Rehmanniae Equivalent is used.

Calyx Hibisci Sabdariffae refers generally to Hibiscus Sabdariffa Linn, Calyx Hibisci Sabdariffae, Chinese medicine name.Root, seed for Malvaceae plant Calyx Hibisci Sabdariffae.Acid, cool.Return Through returning kidney channel.Effect astringing lung-QI and relieving cough, blood pressure lowering, relieves the effect of alcohol." Xinhua's book on Chinese herbal medicine outline " root, seed have diuresis, strong function.

Flos Albiziae filigree pink, pod is inclined, is urban path tree, views and admires tree.Heartwood Huang taupe, sapwood yellow-white, Durable, it is used for furniture processed；Tender leaf is edible, and Lao Ye can do washing clothes；Bark hyoscine, has the effect of anthelmintic.It is also allayed excitement work With, mainly control the effects such as pent-up is uncomfortable in chest, insomnia forgetfulness, nourishing YIN and invigorating YANG, ophthalmic, neurasthenia.

Fructus Atriplicis Sibiricae is bitter, pungent, flat, enters Liver Channel.Function effect suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight.Have a headache for dizziness due to hyperactivity of liver-YANG, stagnation of liver-QI Hypochondriac pain, headache due to pathogenic wind-heat, conjunctival congestion and swelling pain, the disease such as skin pruritus.Containing volatile oil, Saponin, fatty oil, Nitrates, resin, flavonoid Compound and Alkaloid etc..

Semen Cuscutae Cuscuta chinensis is dicotyledon scammonia section plant Semen Cuscutae, Cuscuta australis, cuscuta japonica Choisy etc. Seed, can the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, effect of solid tire stopping leak.Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For Impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen kidney vaginal bleeding during pregnancy, fetal movement Uneasy, spleen is suffered from a deficiency of the kidney and is rushed down；Externally treating leucoderma.Former medicine sieve is removed spare, picks decontamination, dry.

Herba Euphrasiae Regelii Classification system Euphrasia pectinata Ten bitter in the mouth；Cold nature, returns bladder warp, and function cures mainly: clear Thermal detoxification；Diuresis.Main calentura is thirsty；Headache；Cough due to lung-heat；Laryngopharynx swelling and pain；Pyretic stranguria；Dysuria；Aphtha；Carbuncle.

Herba Rabdosiae Lophanthoidis, Classification system Rabdosia serra (Maxim.) Hara, Herba Rabdosiae Lophanthoidis is traditional herbal medicine, is commonly called as Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) Deng, there is clearing away heat-damp and promoting diuresis, jaundice eliminating damp eliminating, effect of cool the blood dissipate blood stasis, be used for treating acute icterohepatitis, acute cholecystitis, dysentery The diseases such as disease, enteritis, traumatic injury stasis of blood pain.Herba Rabdosiae Lophanthoidis has clearing away heat-damp and promoting diuresis, jaundice eliminating damp eliminating, effect of cool the blood dissipate blood stasis, is used for treating urgency Property icterohepatitis, acute cholecystitis, dysentery, enteritis, the difficulty in urination, the disease such as traumatic injury stasis of blood pain.Herba Rabdosiae Lophanthoidis is can not to treat slowly in fact Property hepatitis, if the icteric hepatitis B of samples can do acute treatment with Herba Rabdosiae Lophanthoidis, be that chronic viral hepatitis B is also intended to Do to regular hospital and treat targetedly, the most likely delay treatment, and then increase the difficulty cured.Chinese herbal medicine small stream is yellow Grass has certain effect to hepatitis, but, treatment small three positive effect is the most very limited.

Flos Lonicerae, has another name called Radix Ophiopogonis (formal name used at school: Lonicera japonica)." Flos Lonicerae " one comes from Compendium of Material Medica, by In opening as white at the beginning of Flos Lonicerae, after transfer yellow to, hence obtain one's name Flos Lonicerae.Medical material Flos Lonicerae is Caprifoliaceae woodbine Radix Ophiopogonis And the flower that congener dry flower or band are just opened.Flos Lonicerae is described as the good medicine of lowering blood-fat and reducing weight from ancient times.Its property sweet cold fragrance, Clearing away heat with drugs sweet in flavor and cold in nature and do not injure one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, be also apt to removing summer-heat blood poison, for various heat Sexually transmitted disease (STD), such as fever of the body, dermexanthesis, sends out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, and equal effect is notable.

The specific embodiment of the invention

Specific embodiment 1:

Plucking new fresh Herba Taraxaci, clean and soaked after dry in the sun in ethanol 1-2 hour, heating extraction 2 times, each 1-2 is little Time, taking supernatant, united extraction liquid, 100-120 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, The extractum of 1.06 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component 1.

By remaining crude drug Caulis Spatholobi, Herba Rabdosiae Lophanthoidis, Spica Prunellae, Fructus Mori, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Herba Euphrasiae Regelii, Rhizoma Imperatae, Fructus Ligustri Lucidi, Calyx Hibisci Sabdariffae, Flos Lonicerae, Flos Albiziae, Semen Cuscutae, Herba Ecliptae, Radix Polygoni Multiflori Preparata, Fructus Atriplicis Sibiricae, Fructus Gardeniae, the Radix Rehmanniae, put into weight 10 times amount ethanol In, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, united extraction liquid, after standing, take supernatant, be then placed in decompression In concentration tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, and the relative density of sucking filtration to filtrate is 80 DEG C Time 1.06 extractum, become component 2.

By 2-in-1 to component 1 and component and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is 1.36 Concentrated solution, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted double again In effect vacuum concentrator, it is concentrated into every 1ml crude drug amount Han 0.1g；Unguentum after concentration adds dextrin and is in harmonious proportion, ultraviolet ray sterilization bactericidal Rear bottling.

Specific embodiment 2:

Plucking new fresh Herba Taraxaci, clean dry in the sun, 5000g, Jiang Qipao enter in 10 times amount ethanol altogether, heating extraction 2 times, every time 1-2 hour, taking supernatant, united extraction liquid, 100-120 mesh filters, then the ultrafiltration post that molecular weight is 5000-10000 through damming Ultrafiltration, the extractum of 1.06 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component 1。

By Caulis Spatholobi 1500g, Herba Rabdosiae Lophanthoidis 1500g, Spica Prunellae 1500g, Fructus Mori 1500g, Radix Paeoniae Alba 1500g, Radix Angelicae Sinensis 1500g, Herba Euphrasiae Regelii 1500g, Rhizoma Imperatae 1500g, Fructus Ligustri Lucidi 1500g, Calyx Hibisci Sabdariffae 1500g, Flos Lonicerae 1500g, Flos Albiziae 1500g, Herba cuscutae Sub-1500g, Herba Ecliptae 1500g, Radix Polygoni Multiflori Preparata 1500g, Fructus Atriplicis Sibiricae 1500g, Fructus Gardeniae 1500g, Radix Rehmanniae 1500g, by remaining crude drug Medicine put in 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, united extraction liquid, take after standing Supernatant, is then placed in concentrating under reduced pressure tank, decompression recycling ethanol, and being concentrated into liquor strength is 0.6g crude drug/mL, and sucking filtration is to filter The extractum of 1.06 when the relative density of liquid is 20 DEG C, becomes component 2.

By 2-in-1 to component 1 and component and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is 1.35 Concentrated solution, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted double again In effect vacuum concentrator, it is concentrated into every 1ml crude drug amount Han 0.1g；Unguentum after concentration adds dextrin and is in harmonious proportion, ultraviolet ray sterilization bactericidal Rear bottling.

Specific embodiment 3: pluck new fresh Herba Taraxaci, cleans dry in the sun, altogether after 4500g, puts into extraction pot heating extraction 2 times, 1-2 hour every time, taking supernatant, united extraction liquid, 100-120 mesh filters, then through the molecular weight that dams be the super of 5000-10000 Filter post ultrafiltration, the extractum of 1.06 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 1, will by remaining raw material described Caulis Spatholobi 1200g, Herba Rabdosiae Lophanthoidis 1100g, Spica Prunellae 1100g, Fructus Mori 1200g, Radix Paeoniae Alba 1100g, Radix Angelicae Sinensis 1200g, Herba Euphrasiae Regelii 1100g, Rhizoma Imperatae 1200g, Fructus Ligustri Lucidi 1100g, Calyx Hibisci Sabdariffae 1200g, Flos Lonicerae 1200g, Flos Albiziae 1100g, Semen Cuscutae 1200g, Herba Ecliptae 1100g, Radix Polygoni Multiflori Preparata 1200g, Fructus Atriplicis Sibiricae 1100g, Fructus Gardeniae 1200g, Radix Rehmanniae 1100g, put into weight 5-10 times In amount water, soaking 1-2 hour, heating extraction 2 times, each 1-2 hour, take supernatant, united extraction liquid, 100-120 mesh filters, 2 extracting solution are merged and stands, decompression recycling ethanol, and to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, filtrate When relative density is about 20 DEG C 1.08；Being decompressed to 0.03-0.08MPa, temperature is maintained at 60-80 DEG C, is concentrated into relative density and is 1.20, the extractum of temperature to 60 DEG C-70 DEG C, as component 2.The mixing of component 1 component 2 is inserted in economic benefits and social benefits vacuum concentrator, dense Being reduced to relative density when 90 DEG C is the concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；The drainage that cold preservation liquid is added 0.3% Agent kieselguhr, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 0.1g；Unguentum after concentration Then the quintessence oil adding component 1 adds propolis mediation, bottles after ultraviolet ray sterilization bactericidal.

Specific embodiment 4: pluck new fresh Herba Taraxaci, cleans dry in the sun, altogether after 4500g, steeps in 10 times amount ethanol, and heating carries Taking 2 times, each 1-2 hour, take supernatant, united extraction liquid, 100-120 mesh filters, then through the molecular weight that dams be 5000- The ultrafiltration post ultrafiltration of 10000, the extractum of 1.06 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, quiet Purchase use, become component 1.By Caulis Spatholobi 1200g, Herba Rabdosiae Lophanthoidis 1100g, Spica Prunellae 1100g, Fructus Mori 1200g, Radix Paeoniae Alba 1100g, Radix Angelicae Sinensis 1200g, Herba Euphrasiae Regelii 1100g, Rhizoma Imperatae 1200g, Fructus Ligustri Lucidi 1100g, Calyx Hibisci Sabdariffae 1200g, Flos Lonicerae 1200g, Flos Albiziae 1100g, Semen Cuscutae 1200g, Herba Ecliptae 1100g, Radix Polygoni Multiflori Preparata 1200g, Fructus Atriplicis Sibiricae 1100g, Fructus Gardeniae 1200g, Radix Rehmanniae 1100g, will Described crude drug is put into after pulverizer pulverizes, and particulate matter puts into heating and refluxing extraction 2 times in ethanol, each 1～2 hour, by 2 Secondary extracting solution merges standing；The medicinal residues that above-mentioned ethanol extraction is crossed adding 10 times amount water heating and refluxing extraction 2 times, each 1～2 is little Time, 2 extracting solution are merged and stands, above two extracting solution is merged, as component 2；Merge component 1 component 2 concentrating under reduced pressure The filtrate of 1.36 when relative density is 80 DEG C, reclaims ethanol, calls in propolis, bottles after ultraviolet sterilization.

Pharmacological toxicity is tested

One, skin irritation test

1, experimental technique

Depilatory is uniformly coated with by guinea pig back spinal column both sides, makes unhairing scope about 20 square centimeters.Clean depilatory Returning cage to observe 24 hours, often group Cavia porcellus is coated with the present invention 4,8 and 12g respectively, 92mg, 184mg and 368mg Han crude drug respectively, another Group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment terminates, is put to death by Cavia porcellus, the heart, liver, and kidney and depilation skin do pathology Inspection.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, has no that local skin has edema, hyperemia, erythema, petechia and ulcer. Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity are movable, histopathologic examination, the administration group heart, Liver, kidney and depilation skin compare also no significant difference with compareing word.

Result is pointed out, and the present invention, without local irritant effect, also has no that general toxicity shows.Show that invention formulation uses peace Entirely.

Two, animal acute toxicity test research:

The present invention is through trial test, it is impossible to measures LD 50, therefore measures maximum dosage-feeding.Use rectal delivery, record little The maximum dosage-feeding on the one of Mus is 62.7g/kg (in terms of medicated powder), and about (people is with 60kg for 1567.5 times of the clinical people's consumption of plan Meter), the maximum dosage-feeding 62.7g/kg (in terms of medicated powder) on the one of rat, it is about intend clinical people's consumption 1567.5 times.Experiment is dynamic The equal Continuous Observation of thing one week, its outward appearance sign, the mental status, diet, drinking-water, feces etc. are showed no obvious abnormalities.Experiment terminates Time, all healthy survival of animal, body weight increases.

Three, long-term toxicity test for animals research:

This test sets medicine of the present invention high, medium and low dosage group and Matrix controls group, blank group, uses rectally Approach gives rat, and dosage is respectively 3.2,2.4 and 1.6g/kg (in terms of medicated powder), is equivalent to intend clinical patient consumption 80,60 and 40 times of [0.04g (medicated powder)/kg], successive administration 2 months, in administration process, each administration group and matrix group rat Body weight, dietary amount, outward appearance sign, behavioral activity, the mental status, hair color, feces character compare with blank group, without substantially Not notable (the P ＞ of difference (P ＞ 0.05), the weight of animals increasing value and Main Organ Coefficients and blank group comparing difference 0.05), hematology and blood parameters check notable (the P ＜ of the result indivedual index of administration group and blank group comparing difference 0.05), but convalescent period terminates rear discrepant hematology and blood parameters has recovered normal the most, and other indexs are right with blank Not notable (P ＞ 0.05) according to comparing difference, it is administered phase and convalescent period histological examination high dose group animal main organs with blank Matched group compares and has no notable difference, has no that slowness toxicity occurs.

Pharmacological experiment:

Along with industrialized development, the change of dietary structure, the improvement of living condition, overweight and obese people quantity exists Increase rapidly in world wide, and in the trend of becoming younger, become the global epidemic diseases having a strong impact on health, therefore, find strong The effective method of weight-reducing of health has a most real significance, and safely and effectively anti-obesity activity material is always people and expects to solve The key of problem of obesity.

1 materials and methods

1.1 materials and instrument

High lipid food standard formula full price Mus feedstuff 60% used by experimental rat nursing, Adeps Sus domestica 14%, sucrose 5%, milk Powder 5%, Semen arachidis hypogaeae 5%, egg 8%, Oleum Sesami 1%, Sal 2%, processed by Animal Science company limited of Shandong University；Other Agents useful for same is commercially available analytical pure；T-CHOL detection kit, triglyceride detection kit and high density lipoprotein detection The firelight or sunlight biological company limited of test kit wound；Just the male SD rat 100 of ablactation is only provided by Shandong University's Experimental Animal Center, raises In this school SPF level animal experimental center temperature (25 ± 2) DEG C, relative humidity is 50%.BP211D type electronic analytical balance Germany Satrorius company；202 type Constant Temp. Oven Shanghai Suo Pu Instrument Ltd.；1-15PK small desk frozen centrifugation Sigma company of machine Germany；TU-1800S ultraviolet-uisible spectrophotometer Beijing Puxi General Instrument Co., Ltd；PUZS- 300 full automatic biochemical apparatus Nanjing Pu Lang medical equipment company limiteies；Rustless steel rat metabolism cage Beijing good Asource industry science and technology is limited Company；SOX406 Milko-Tester Jinan Hanon Instruments Ltd..

1.2 present invention feed and high fat are fed the impact that rat body weight increases

1.2.1 laboratory animal and the packet growth male Wistar rat of 3 months, body weight (220 ± 10) g, sum 50 Only, Shandong University's Experimental Animal Center provide, raise in this school SPF level animal experimental center [temperature (25 ± 2) DEG C, relatively Humidity is 50%].It is randomly divided into 5 groups, often group 10 by body weight.Animal packet is as follows with administrations:

Blank group (Blank): the appearance normal saline such as gavage, continuous 9 weeks；Herb Gynostemmae Pentaphylli group (CH): 400mg/kg/d, fills continuously Stomach 9 weeks；Other raw material group (CU): 400mg/kg/d, continuous gavage 9 weeks；Low dose group of the present invention (CH+CU-low): 400mg/ Kg/d, continuous gavage 9 weeks；High dose group of the present invention (CH+CU-high): 800mg/kg/d, continuous gavage 9 weeks.

1.2.2 observation index and the original body mass of detection method precise rat, is distributed into cage, 1, every cage, it is ensured that water With being sufficiently fed of food, measure weekly the intake of food and water, measure increased weight weekly simultaneously.1st week and the 9th week fixed Time eye socket take blood 0.5mL, immediately in 2500r/min frozen centrifugation 2min, total solid in automatic clinical chemistry analyzer detection serum Alcohol, high-density protein and content of triglyceride.Experiment in 9th week terminates front 1d, and rat is put in metabolic cage, collects 24h animal Void excreta, measure feces gross weight, take quantitative dry sample feces, soxhlet extraction methods measures the excrement fat content in feces, with Time calculate excrement body weight when excrement fat weight ratio.

1.3 present invention feed the impact on obese rat fat-reducing

1.3.1 Diet-induced obesity rat molding method 10 is standard full price Mus forage feed, feeds with high lipid food for 90 Support.After feeding 3 months, with body weight exceed chow diet feed rat body weight meansigma methods 20% as obesity standard, modeling success 49, success rate is 54.4%.

1.3.2 packet and the successful obese rat of processing method modeling change to the nursing of standard complete feed subsequently, by body Heavily it is randomly divided into 5 groups, often group 9.Blank group (Blank): model comparison rat, gavage equal solvent normal saline, continuous 4 weeks； Herba Taraxaci group (CH): 400mg/kg/d, gavage is treated 4 weeks；Other raw material group (CU): 400mg/kg/d, gavage is treated 4 weeks；This Invention low dose group (CH+CU-low): 400mg/kg/d, gavage is treated 4 weeks；High dose group of the present invention (CH+CU-high): 800mg/kg/d, gavage is treated 4 weeks.

1.3.3 body weight before and after observation index and detection method weigh with electronic scale and treat, calculates body weight decrement before and after being administered, Account for using body weight decrement and be administered the percentage rate of front body weight as weight-loss ratio.Experiment terminates the previous day, and rat eye socket is taken blood 2mL, vertical I.e. in 2500r/min frozen centrifugation 2min, total sterin, high density lipoprotein level Pseudobulbus Bletillae (Rhizoma Bletillae) in automatic clinical chemistry analyzer detection serum are sweet Oil three ester contents.Experiment puts to death rat after terminating, and takes under omoplate fat (brown fat) after item and weighs；Take kidney week Abdominal Wall Fat and Epididymal adipose tissues (white adipose), represents visceral fat mass with both sums；Calculate fat after interior fat weight ratio and item simultaneously Weight ratio.

1.4 data statistic analysis

Carry out data statistic analysis with SPSS 100 software, use Homogeneity-of-variance to carry out variance neat Property inspection, if variance is neat, then carry out one factor analysis of variance, and use Dunnett-test to carry out experimental group and matched group mean Between compare two-by-two；If heterogeneity of variance, then make nonparametric statistics with Kruskal-Wallistest, enter with Mann-Whitneytest Compare two-by-two between row mean.

2 results and analysis

2.1 present invention feed and high fat are fed the impact that rat body weight increases: without rats death in whole experimentation, Subordinate act and figure observe each test group of animals without significantly taking untoward reaction.Specific experiment result is as shown in Table 1 to Table 3.

Table 1 animal subject food ration, amount of drinking water and increased weight change (n=10, X ± SD) weekly

Note: represent with column data acceptance of the bid note same letter and there was no significant difference (p > 0.05)；Difference then has significant difference (p<0.05)；Table 2～table 5 are same.

As shown in Table 1, each test group of animals amount of drinking water and food ration are substantially suitable, illustrate that gavage gives each active component not Affecting rat ingest and freely drink water, activity and the digestive system function of each group laboratory animal are normal.With this understanding, with blank Group is compared by rat, becomes slow to the rat body weight increase of Herb Gynostemmae Pentaphylli He other raw materials, but inconspicuous (p ＞ 0.05)；And give The compositions of high and low dose of the present invention can the most significantly suppress the body weight of rat to increase, and depression effect is respectively the 3rd, 4 (p ＜ 0.05) occur during week, and extend in time and strengthen, the weight of animals increase suppression giving high dose composition is brighter Aobvious.

The body weight increase of blank group rat is the feedstuff owing to intake of high fat height sugar, after superfluous nutritional labeling is taken in, Internal through being absorbed into, then through transhipment, metabolism and conversion, savings are in adipose cell, and are accumulated in different organs and group In knitting, cause fat.Though and give curcumin and chitosan does not reduce food ration, but other fat processes can be being formed Play a role.The effect of Herba Taraxaci is by adsorbing and combine substantial amounts of fat in animal gastrointestinal tract, forms feces and discharges body Outward, so that the relative absorbance amount of fat reduces, the generation that suppression is fat；It also has an effect to be to pass through after fat absorption Promote lipid metabolism, thus drop low-fat internal relative accumulation amount, thus suppress fat.

Blood lipid level change (n=10, X ± SD) of table 2 animal subject

As shown in Table 2, when testing 1 week, the level of each group T-CHOL of rat, triglyceride and high density lipoprotein without Notable difference (p ＞ 0.05)；After gavage 9 weeks, and give triglyceride and the high density lipoprotein level plain boiled water of the experimental rat of compositions Put down and have certain decline, but trend inconspicuous (p ＞ 0.05).Laboratory animal is during high fat is fed, although give various It is administered and intervenes, but the blood lipid level in phase (1 week) and later stage (9 weeks) still accordingly increases before treatment.Use with each treated animal The blood lipid level fed 9 weeks deducts the result of blood lipid level when feeding 1 week and represents blood lipid level increment, finds to give strand Indigo plant or other raw materials or a combination of both thing present invention all can reduce the blood lipid level increment of rat during high fat is fed, its Middle of the present invention group of blood lipid level increment is minimum, and effect is best, illustrates that giving the present invention can effectively suppress high fat to feed rat Blood lipid level increases.

The situation (n=10, X ± SD) of table 3 animal subject fat excretion

Table 3 result shows, high and low dose of the present invention all can promote the defecation of rat to a certain extent, but Fecal wastes without Significantly difference (p ＞ 0.05), but excrement fat amount and excrement fat weight ratio have and significantly increase (p ＜ 0.05), illustrates to give above-mentioned Material can play the effect of fat consumption, gives other raw material groups and then acts on without this.This is because Herba Taraxaci therein exists There is the function of stronger absorbing fats, it is possible to promote the consumption of fat, thus play preferable fat-reducing effect in organism.

2.2 curcumins and chitosan feed to each test group of animals in the whole experimentation of fat-reducing effect of obese rat without Substantially taking untoward reaction, specific experiment result is as shown in table 4～table 5.

The relevant body weight parameters (n=9, X ± SD) of tested obese rat respectively organized by table 4

As shown in Table 4, after modeling success, the body weight average of obese rat, more than 630g, gives active substance gavage 4 weeks After, Herba Taraxaci group, the body weight relatively matched group of present composition group obese rat have significance to alleviate (p ＜ 0.05), and other are former Material group also has certain phenomenon that loses weight, but compares inconspicuous (p ＞ 0.05) with blank group, and the effect of compositions is better than list Solely using Herba Taraxaci and other raw materials (p ＜ 0.05), and present a certain amount effect relationship, high dose effect is more preferable.

The different fat sites content (n=9, X ± SD) of tested obese rat respectively organized by table 5

As shown in Table 5, compared with blank group, alone Herba Taraxaci and other raw materials can reduce the interior fat of obese rat Content and internal organs fat body ratio (p ＜ 0.05), the present invention has effect (the p ＜ substantially reducing obese rat interior fat equally 0.05), its effect is even better than Herba Taraxaci or alone group of other raw materials, and present composition high dose effect is more notable, so that Also show and significantly reduce the effect (p ＜ 0.05) of fat body ratio after fat and item after the item of obese rat.

The present invention demonstrates Herba Taraxaci in whole animal level and has the preferably increase of suppression body weight and fat-reducing effect, and Herba Taraxaci and other raw materials of the present invention are with the use of rear, and both serve the effect of Synergistic.

Claims

1. the preparation method of the Herba Taraxaci oral liquid of a lowering blood-fat and reducing weight, it is characterised in that comprise the following steps:

A. the preparation of Herba Taraxaci, as component 1；

C. by 2-in-1 also to above two extracting solution component 1 and component, add Mel after concentration or dextrin is in harmonious proportion, prepare after disinfection Become oral liquid bottling.

The preparation method of the Herba Taraxaci oral liquid of lowering blood-fat and reducing weight the most according to claim 1, it is characterised in that described step a In, pluck Herba Taraxaci, after clean dry, soaked in the ethanol accounting for its quality 10 times amount 1-2 hour, be then placed in extraction pot Heating extraction 2 times, each 1-2 hour, takes supernatant, united extraction liquid, and 100-120 mesh filters, then through the molecular weight that dams is The ultrafiltration post ultrafiltration of 5000-10000, the extractum of 1.06 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into cream Shape, stand for standby use, become component 1 standby.

The preparation method of the Herba Taraxaci oral liquid of lowering blood-fat and reducing weight the most according to claim 1, it is characterised in that described step b In, remaining raw material described is steeped and accounts in its quality 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, take supernatant, close And extracting solution, 100-120 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, ultrafiltrate concentrating under reduced pressure The extractum of 1.06 when relative density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component 2.

The preparation method of the Herba Taraxaci oral liquid of lowering blood-fat and reducing weight the most according to claim 1, it is characterised in that described step c In, by 2-in-1 to component 1 and component and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentration of 1.36 Liquid, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and it is true that filtrate inserts economic benefits and social benefits again In empty concentrator, it is concentrated into every 1ml crude drug amount Han 0.1g；Unguentum after concentration adds Mel or dextrin is in harmonious proportion, and disinfection by ultraviolet light kills Bottle after bacterium.

5. the preparation method of the Herba Taraxaci oral liquid of a lowering blood-fat and reducing weight, it is characterised in that preparation process is:

A. by Herba Taraxaci extracting in water, as component 1；

The preparation method of the Herba Taraxaci oral liquid of lowering blood-fat and reducing weight the most according to claim 5, it is characterised in that described step a In, the Herba Taraxaci plucked is cleaned, puts into extraction pot heating extraction after dry in the sun 2 times, each 1-2 hour, take supernatant, merge Extracting solution, 100-120 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 5000-10000 through damming, ultrafiltrate concentrating under reduced pressure phase The extractum of 1.06 when being 80 DEG C to density, as component 1；In described step b, by the Herba Taraxaci dregs that extract with described remaining is former Material is put into together and is accounted in its quality 5-10 times amount water, soaks 1-2 hour, heating extraction 2 times, each 1-2 hour, takes supernatant, United extraction liquid, 100-120 mesh filters, and 2 extracting solution is merged and stands, reduce pressure and be concentrated into liquor strength be 0.6g crude drug/ ML, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08；Being decompressed to 0.03-0.08MPa, temperature is maintained at 60-80 DEG C, Being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, as component 2.

The preparation method of the Herba Taraxaci oral liquid of lowering blood-fat and reducing weight the most according to claim 5, it is characterised in that described step c In, put into concentrating under reduced pressure tank, decompression recycling ethanol with component 2 after component 1 being mixed, being concentrated into liquor strength is that 0.1g is raw Medicine/mL, when the relative density of sucking filtration to filtrate is 20 DEG C 1.06；Above-mentioned filtrate is inhaled through the macroporous adsorptive resins that volume is 10L Attached, with deionized water or the distilled water eluting of 10 times of resin column volumes, then with 95% ethanol elution of 5 times of resin column volumes, Collect ethanol elution, remove solvent, then be in harmonious proportion Mel, bottle after ultraviolet ray sterilization bactericidal.

8. the Herba Taraxaci oral liquid of a lowering blood-fat and reducing weight, it is characterised in that include the crude drug of following parts by weight: Herba Taraxaci 10 ～50 parts, Caulis Spatholobi 10～20 parts, Herba Rabdosiae Lophanthoidis 10～20 parts, Spica Prunellae 10～20 parts, Fructus Mori 10～20 parts, the Radix Paeoniae Alba 10～20 Part, Radix Angelicae Sinensis 10～20 parts, Herba Euphrasiae Regelii 10～20 parts, Rhizoma Imperatae 10～20 parts, Fructus Ligustri Lucidi 10～20 parts, Calyx Hibisci Sabdariffae 10～20 parts, Flos Lonicerae 10～20 parts, Flos Albiziae 10～20 parts, Semen Cuscutae 10～20 parts, Herba Ecliptae 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, in vain Fructus Tribuli 10～20 parts, Fructus Gardeniae 10～20 parts, the Radix Rehmanniae 10～20 parts.

The Herba Taraxaci oral liquid of lowering blood-fat and reducing weight the most according to claim 8, it is characterised in that include the former of following parts by weight Material medicine: Herba Taraxaci 10～30 parts, Caulis Spatholobi 10～15 parts, Herba Rabdosiae Lophanthoidis 10～15 parts, Spica Prunellae 10～15 parts, Fructus Mori 10～15 Part, the Radix Paeoniae Alba 10～15 parts, Radix Angelicae Sinensis 10～15 parts, Herba Euphrasiae Regelii 10～15 parts, Rhizoma Imperatae 10～15 parts, Fructus Ligustri Lucidi 10～15 parts, rose Rare eggplant 10～15 parts, Flos Lonicerae 10～20 parts, Flos Albiziae 10～20 parts, Semen Cuscutae 10～20 parts, Herba Ecliptae 10～20 parts, system head Crow 10～20 parts, Fructus Atriplicis Sibiricae 10～20 parts, Fructus Gardeniae 10～20 parts, the Radix Rehmanniae 10～20 parts.

The Herba Taraxaci oral liquid of lowering blood-fat and reducing weight the most according to claim 1, it is characterised in that various former in described oral liquid The parts by weight of material medicine are: Herba Taraxaci 10～40 parts, Caulis Spatholobi 10～20 parts, Herba Rabdosiae Lophanthoidis 10～20 parts, Spica Prunellae 10～20 parts, Fructus Mori 10～20 parts, the Radix Paeoniae Alba 10～20 parts, Radix Angelicae Sinensis 10～20 parts, Herba Euphrasiae Regelii 10～20 parts, Rhizoma Imperatae 10～20 parts, Fructus Ligustri Lucidi 10 ～20 parts, Calyx Hibisci Sabdariffae 10～20 parts, Flos Lonicerae 10～15 parts, Flos Albiziae 10～15 parts, Semen Cuscutae 10～15 parts, Herba Ecliptae 10～ 15 parts, Radix Polygoni Multiflori Preparata 10～15 parts, Fructus Atriplicis Sibiricae 10～15 parts, Fructus Gardeniae 10～15 parts, the Radix Rehmanniae 10～15 parts.