CN104435244A

CN104435244A - Traditional Chinese medicine composition for effectively treating mammary cancer

Info

Publication number: CN104435244A
Application number: CN201310418884.8A
Authority: CN
Inventors: 杨江
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-09-14
Filing date: 2013-09-14
Publication date: 2015-03-25

Abstract

The invention discloses a traditional Chinese medicine composition for effectively treating mammary cancer. The traditional Chinese medicine composition is obtained by clinical test repeated-verification based on the traditional Chinese medicine treatment principle according to modern pharmacological research results and traditional Chinese medicine theory. The traditional Chinese medicine composition for effectively treating mammary cancer has good treatment effects, is safe and reliable and has no side effect. The traditional Chinese medicine composition for effectively treating mammary cancer comprises, by weight, 0.1-0.9 parts of pangolin, 0.02-0.08 parts of spina gleditsiae, 1-5 parts of Chinese angelica, 0.1-0.9 parts of licorice root, 1-9 parts of honeysuckle flower, 1-9 parts of red peony root, 1-9 parts of frankincense, 1-9 parts of myrrh, 1-9 parts of dahurian angelica root, 1-9 parts of rheum officinale, 1-9 parts of dried orange peel, 1-9 parts of scorpion, 1-9 parts of divaricate saposhnikovia root, 0.1-0.9 parts of bee pollen and 1-9 parts of rhizoma bolbostemmae.

Description

A kind of Chinese medicine composition of effective treatment breast carcinoma

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine composition of effective treatment breast carcinoma.

Background technology

Breast carcinoma refers to the malignant tumor in breast portion.Be equivalent to the breast carcinoma of doctor trained in Western medicine.Be characterized in that painless, nothing heat, the constant and scleroid lump of color of the leather appear in breast portion, what push away does not move, rough, uneven, or nipple hemorrhage, and late period festers, recessed as general lotus.It is one of modal malignant tumor of women.Atoke history or the women without lactation history, menstruation rise too early or menopause more evening women and have the sickness rate of the women breast cancer of family history of breast cancer relatively high.The less generation of male breast carcinoma.

[etiology and pathogenesis]

The pathogeny of breast carcinoma has the following aspects:

(1) disorder of emotion feelings will is smooth, and it is unsuccessful that institute is willing to, liver mistake bar reaches, functional activity of QI being not smooth, and the stagnation of QI is the stasis of blood then; Stagnation of liver-QI gram violates spleen soil, the transformation failure of spleen then turbid interior life of expectorant, and liver spleen two is hindered, and meridians block, and phlegm and blood stasis is fallen ill in breast.

(2) intemperance of taking food processs Bo then stagnation of spleen and stomach damp-heat addicted to savoury for a long time, and change raw expectorant turbid, alter, tie in Ruzhong with air-flow, block meridians, QI and blood is not all right, with the passing of time diagenesis.

(3) disharmony of Chong and Conception Channels CHONG meridian being the blood pool, REN meridian connecting with the uterus and pregnancy, the arteries and veins that punching is appointed is under the jurisdiction of Liver and kidney.Chong and Ren channel disorder, then qi-blood disharmony, menstruation is not all right, stagnation of QI blood stasis, blocks meridians, ties and form breast carcinoma in Ruzhong.Before and after breast carcinoma is mainly in menopause, therefore there is substantial connection with Chong and Ren channel disorder.

In addition, when through the deficiency of vital energy is weak, the gas be affected by the cold, blocks meridians, qi depression to blood stasis, and with the passing of time the retention of phlegm knot stasis of blood, also can cause breast carcinoma.

In a word, the morbidity of breast carcinoma is disorder of emotion, intemperance of taking food, disharmony of Chong and Conception Channels, and the gas of affection of exogenous wind-cold or natural endowment deficiency cause body imbalance between YIN and YANG, and internal organs are become estranged and fall ill.

[clinical manifestation of breast carcinoma]

Age of onset is generally at 40 ~ 60 years old, and menopausal women sickness rate is relatively high.

Breast carcinoma can be divided into general type of mammary cancer and Special Types of Breast Cancer.

(1) general type of mammary cancer

Normal is Silent Neuritis lump in breast, obscure boundary, and quality is hard, rough, not easily promotes, and normal and skin adhesion, occurs lesion center dimple sign, can accompany nipple discharge individually.Later stage increases gradually along with cancerous protuberance, produces pain in various degree, and skin can be orange peel edema, variable color; Can be there is the little lump be dispersed in perilesional, shape is as heap chestnut; Retracted nipple or raise, medical education net arranges occasionally can see skin ulcer.Late period, lump in breast festered, and open sore part edge is irregular, and concavity like cave, turns up like cauliflower sometimes, time ooze purplish red blood and slime, stench is unpleasant.When cancerous protuberance is transferred on oxter and clavicle, can touch be dispersed in, number is few, matter is firmly painless swollen thing, later gradually large, mutual adhesion, merges agglomerating, then occurs emaciated physique, pale complexion, the cachexia looks such as wan and sallow.

(2) Special Types of Breast Cancer

1. inflammatory carcinoma: rare clinical, is mainly in young women, and half occurs in gestation or age of sucking.Onset is hurried, and breast increases rapidly, hydroderma, hyperemia, rubescent or aubergine, heating; But do not have obvious lump to lay one's hand on and.Transfer is very wide, and namely contralateral breast is often invaded soon, and occurs axillary region, supraclavicular lymph nodes enlargement very early.Primary disease grade malignancy is high, and the course of disease is very brief, often dead in 1 year.

2. eczematoid carcinoma: clinical more rare, its sickness rate accounts for 0.7% ~ 3%. clinical manifestation of women with breast cancer like chronic eczema, the skin rubefaction of nipple and mammary areola, slightly rotten to the corn, has serosity to ooze out, thus moist, is sometimes covered with filemot squamous crust.The skin of pathological changes is very hard, with around demarcate clear.Most of patients is felt very to itch, or has slight causalgia.Medical education net arranges pathological changes after the several years in mid-term and spreads to mammary areola with outer skin, and color is purple and hard, crater nipple.Later stage is easy to hemorrhage after bursting, and nipple erosion falls, and the open sore part caves in, and edge is hard, also can occur hard lump in breast.

[Differential Diagnosis]

(1) nodules of the breast is apt to occur in 30 ~ 45 years old women.Menstrual phase mastalgia, swells.Have the nodositas or the block lump of sheet that differ in size, obscure boundary, quality is pliable and tough, is often bilateral.Lump and skin adhesion.

(2) nodule in the breast is more common in the women of 20 ~ 30 years old, and lump is multiple is born in side, and shape is as ball ovum, and surface is solid smooth, and clear border, mobility is good, can pass.Course advancement is slow.

Current treatment breast carcinoma the best way is exactly traditional Chinese medical herbal treatment method.

Summary of the invention

The present invention is based on China traditional medicine Therapeutic Principle, with reference to modern pharmacological research, follow tcm theory, form a kind of Chinese medicine composition of effective treatment breast carcinoma through clinic tests and repeated verification configuration.

Object is to provide the Chinese medicine composition of a kind of effective treatment breast carcinoma that a kind of therapeutic effect is good, safe and reliable, be free from side effects.

The Chinese medicine composition of a kind of effective treatment breast carcinoma of the present invention, is made up of the raw material of following weight portion:

Squama Manis 0.1-0.9 part, Spina Gleditsiae 0.02-0.08 part, Radix Angelicae Sinensis 1-5 part, Radix Glycyrrhizae 0.1-0.9 part, Flos Lonicerae 1-9 part, Radix Paeoniae Rubra 1-9 part, Olibanum 1-9 part, Myrrha 1-9 part, Radix Angelicae Dahuricae 1-9 part, Radix Et Rhizoma Rhei 1-9 part, Pericarpium Citri Reticulatae 1-9 part, Scorpio 1-9 part, Radix Saposhnikoviae 1-9 part, bee pollen 0.1-0.9 part, Rhizoma Bolbostematis 1-9 part;

The dosage form of Chinese medicine composition is capsule, and its preparation process comprises:

A, extracting liquorice, Pericarpium Citri Reticulatae and Flos Lonicerae, add the water soaking 1-2 hour of 5-10 times amount, extracts the volatile oil of 2-5 hour, collects volatile oil, and medicinal liquid filters, for subsequent use;

B, medicinal residues and other crude drug add 60-90% ethanol, soak 0.5-1.5 hour, extract twice, each 1-2 hour, and first time adds 5-10 times amount, and second time adds 5-10 times amount, merge extractive liquid, filter; Above two filtered solutions merge and filter, and filtered solution are evaporated to 1.10-1.50 precipitate with ethanol twice when relative density is 80 DEG C, adjust concentration of alcohol 60-90%, 1.10-1.50 when to get supernatant concentration to relative density be 80 DEG C;

C, get above-mentioned extractum, add volatile oil and vegetable oil is appropriate, mixing, grinds 10 minutes with colloid mill, constantly stirs, be chilled to room temperature.

As preferably, described preparation method, is characterized in that, the extraction of volatile oil contained by Radix Glycyrrhizae, Pericarpium Citri Reticulatae and Flos Lonicerae in step a, is steam distillation or supercritical fluid extraction.

As preferably, described preparation method, is characterized in that, the method in step b adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.

The dosage form of Chinese medicine composition is the preparation process of enema:

A, get crude drug and add water extraction 2 times, becoming extractum shape, is component 1;

It is extractum shape that b, medicinal residues add ethanol thickening filtration, is component 2;

C, by concentrated for above-mentioned two kinds of extractum mixing.

As preferably, in described step b, medicinal residues add 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, filters, concentrated, 80-160 order filter, 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.35 extractum, heating and refluxing extraction 2 times, each 30 minutes ~ 45 minutes, extracts active ingredient, 2 extracting solution are merged and is settled into extractum shape, as component 2.

As preferably, get above-mentioned enema 100mL ~ 200mL during use, retention enema at every turn, pour into 30mL ~ 50mL, inject with No. 12 oxygen catheters and 50mL syringe, insertion depth is 15cm ~ 20cm at every turn, 2 ~ 3 times/d, 7d are 1 basic course for the treatment of, each 20min-40min.

A kind of Chinese medicine composition of effective treatment breast carcinoma, it is characterized in that, the dosage form of described Chinese medicine composition is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, injection, suppository, plaster, syrup, enema or patch.

Squama Manis 0.2-0.8 part, Spina Gleditsiae 0.03-0.07 part, Radix Angelicae Sinensis 2-4 part, Radix Glycyrrhizae 0.2-0.8 part, Flos Lonicerae 2-8 part, Radix Paeoniae Rubra 2-8 part, Olibanum 2-8 part, Myrrha 2-8 part, Radix Angelicae Dahuricae 2-8 part, Radix Et Rhizoma Rhei 2-8 part, Pericarpium Citri Reticulatae 2-8 part, Scorpio 2-8 part, Radix Saposhnikoviae 2-8 part, bee pollen 0.2-0.8 part, Rhizoma Bolbostematis 2-8 part.

Squama Manis 0.5 part, Spina Gleditsiae 0.05 part, Radix Angelicae Sinensis 3 parts, 0.5 part, Radix Glycyrrhizae, Flos Lonicerae 5 parts, Radix Paeoniae Rubra 5 parts, Olibanum 5 parts, Myrrha 5 parts, the Radix Angelicae Dahuricae 5 parts, Radix Et Rhizoma Rhei 5 parts, Pericarpium Citri Reticulatae 5 parts, Scorpio 5 parts, Radix Saposhnikoviae 5 parts, bee pollen 0.5 part, Rhizoma Bolbostematis 5 parts.

The property of medicine and the pharmacology of Chinese herbal medicine selected by the present invention are respectively:

Squama Manis:

[effect]: the routed carbuncle of detumescence, searches wind active, can blood circulation promoting and dispersing pathogen accumulation, stimulating milk secretion of stimulating the menstrual flow, the routed heavily fortified point of eliminating carbuncle.Main blood stasis amenorrhea, lump in the abdomen, rheumatic arthralgia, agalactia, carbuncle, scrofula etc.

[curing mainly]: control carbuncle skin ulcer and swell, anemofrigid-damp arthralgia, amenorrhea, galactostasis, has blood in stool.[meridian distribution of property and flavor]: salty in the mouth, cool in nature.1. " do not record": " be slightly cold." 2. " the property of medicineopinion ": " very toxic." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine": " cold, salty in the mouth." enter liver, stomach warp ^[3].1. " detailed outline": " enter to faint the bright warp of yin, yang." 2. " book on Chinese herbal medicine converges and says ": " enters lunar, the JUE YIN meridian of foot."

Spina Gleditsiae:

Spina Gleditsiae is pungent, temperature.Return liver, stomach warp, evacuation of pus of drawing out pus by applying a plaster to the affected part, promoting blood circulation and detumescence.For carbuncle, sore, pus becomes not burst, scabies.

Radix Angelicae Sinensis:

Another name: radix Angelicae Sinensistail, Radix Angelicae Sinensis, return and must, return lower limb, slightly return lower limb.

Profile:

Radix Angelicae Sinensis root is slightly cylindrical, and root upper end claims " returning head ", main rootclaim " return body" or " very little body ". supporting root claims " Radix Angelicae Sinensis " or " returning lower limb ", all titles " radix Angelicae Sinensis".

Entirely radix Angelicae Sinensisenrich blood and invigorate blood circulation, radix Angelicae Sinensis bodyenrich blood, Radix Angelicae Sinensis is invigorated blood circulation.

[meridian distribution of property and flavor]: pungent, sweet, warm.

[curing mainly]: promoting blood circulation and breaking stagnation, menstruction regulating and pain relieving.Control menoxenia, dysmenorrhea, stomachache, traumatic injury, skin infection.

[effect] Radix Angelicae Sinensis is controlled apoplexy syncope, is spat out white foams, puerperal paralysis.There is oxygen lack resistant function; Radix Angelicae Sinensis has conditioner body immunity function, has antitumaous effect; Radix Angelicae Sinensis has cosmetology effect; Radix Angelicae Sinensis is enriched blood the effect of invigorating blood circulation; Radix Angelicae Sinensis has antibacterial, arteriosclerosis effect.

Modern study finds, Radix Angelicae Sinensis contains multiple organic principle and the trace element such as a large amount of volatile oil, vitamin, organic acid, and experimentation shows, Radix Angelicae Sinensis can expand peripheral blood vessel, reduces vascular resistance, increases circulating liquid measure etc.Tryrosinase in human body can produce the melanin causing freckle, black speck, senile plaque, and its activity is higher, then the appearance of senile plaque more early, and quantity is also more.In recent years, physician to Tang Dynasty in China Sun Simiao work supplement to Thousand Golden Prescriptions in anti-ageing speckle removing, skin health-care " married woman face medicine " carried out scientific validation, therefrom filter out the highest medicine of frequency of utilization, result shows, the function of the aqueous solution restraint of tyrosinase activity of Radix Angelicae Sinensis is very strong, thus can the formation of check melanin, produces effects well to pigmented dermatosis such as treatment chloasma, freckle etc., there is defying age and beautification function, contribute to people's youth is resided.Radix Angelicae Sinensis is added in cosmetic cream, QUBAN SHUANG, and in the hope of skin nutrition in capsule snow phenanthrene, prevent pachylosis, prevent and treat the effects such as acne, chloasma, freckle, without any side effects through observing.Radix Angelicae Sinensis can also promote natural on-off cycles of hair growth, the hair conditioner made with Radix Angelicae Sinensis, hair cream, hair soft can be made shinny, be easy to combing.

Radix Angelicae Sinensis volatile oil and ferulic acid can suppress uterine myometrium, and its water alcohol dissolubility nonvolatile matter, then uterine smooth muscle can be made excited.The effect of Radix Angelicae Sinensis to uterus is depended on the functional status in uterus and is Biphasic Regulation.N-butene lactone can to antihistamine-caused guinea pig experimental asthma of acetylcholine spraying.Radix Angelicae Sinensis has anti-platelet aggregation and anti thrombotic action, and can promote hemoglobin and erythrocytic generation; Resist myocardial ischemia and blood vessel dilating effect, and prove that ferulic acid can improve peripheral circulation; Radix Angelicae Sinensis has protective effect to the hepatic injury that experimental carbon tetrachloride causes, and can promote the effect of liver cell regeneration and some function of recovery liver.In addition, also have calmness, analgesia, antiinflammatory, anti-hypoxia, Antiradiation injury and suppress the growth of some tumor line and vitro antibacterial activity etc.

Radix Glycyrrhizae:

[nature and flavor] sweet in the mouth is put down,

[effect] invigorating the spleen and replenishing QI, lung moistening are eliminated the phlegm, heat-clearing and toxic substances removing.

Flos Lonicerae:

[nature and flavor] property is sweet, cold;

[function] has heat clearing away, removing toxic substances, antiinflammatory, antibacterial effect.Compendium of Material Medica is carried " Flos Lonicerae, is good at removing toxic substances, therefore controls carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer, also for anemopyretic cold, and the diseases such as bronchitis.Modern pharmacological research shows, Flos Lonicerae has the effect such as antibacterial, antiviral, antiinflammatory, antipyretic, immunity moderation.

The loose poison of heat clearing away, Compendium of Material Medica is carried " Flos Lonicerae, is good at removing toxic substances, therefore controls carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer.Modern pharmacological research shows, Flos Lonicerae has the effect traditional Chinese medical science such as antibacterial, antiviral, antiinflammatory, antipyretic, immunity moderation and thinks, Flos Lonicerae is cold in nature, sweet in the mouth, gas flat, has effect of heat-clearing and toxic substances removing, can treat the disease such as pyretic toxicity abscess, carbuncle furuncle.And have the loose effect of a surname concurrently.Flos Lonicerae antipyretic and antidote functions is quite strong.Flos Lonicerae can delay the pathological changes effect of Respirovirus to cell, is the representative medicine of heat-clearing and toxic substances removing, and pyretic toxicity essence is except containing multiple pathogenic microorganism, and microbial toxin also accounts for critical positions.Caused by the endotoxin that Flos Lonicerae preparation lumbar injection obviously can reduce bacillus pyocyaneus, the leukocyte count of rabbit declines, and deviation to the left phenomenon etc. has obvious antagonism.Flos Lonicerae compatibility Radix Scutellariae is prepared into poisoning symptom and the death that preparation obviously can alleviate bacillus pyocyaneus endotoxin caused rabbit.

Radix Paeoniae Rubra:

Radix Paeoniae Rubra is parts of generic medicinal plants, originates in China's most area, is plant radix Paeoniaeor river Radix Paeoniae Rubraroot, its effective ingredient is mainly paeoniflorin (paeoniflorin).Radix Paeoniae Rubra sour in the mouth is bitter, cold nature, kindly divides the stasis of blood that is hot and suffocating and that can fall apart in blood except nutrient blood, has removing heat from blood to purge heat the effect of dissipating blood stasis, commonly uses the card controlling all heat in blood, blood stasis, therefore title " can rush down and can fall apart ".Its bitter cold cooling blood and dissolving stasis, the carbuncle that also can fall apart, removing fire from the liver, removing blood stasis with potent drugs blood, stimulates the menstrual flow and closes.Be applicable to pyretic toxicity carbuncle and the not all right amenorrhea of women's blood stasis, and the various pain caused because blood retardance.But the patient of deficient qi and blood should not use to puerperal.

[meridian distribution of property and flavor]: bitter, is slightly cold.Return Liver Channel.

[attending effectiveness]: clearing away heat and cooling blood; Blood circulation promoting and blood stasis dispelling.Main maculae caused by violent heat pathogen; Hematemesis and epistaxis; Discharging fresh blood stool; Conjunctival congestion and swelling pain; Carbuncle skin infection; Amenorrhea; Dysmenorrhea; Metrorrhagia and leukorrhagia stranguria with turbid discharge; The stagnant hypochondriac pain of the stasis of blood; Hernia abdominal mass is gathered; Injury from falling down.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.

Olibanum: regulating QI, invigorates blood circulation, and pain relieving chases after poison.Antibacterial, restrain, flatulence of dispelling, promote wound scab, promote cytoactive, profit digestion, diuresis, calmness, benefit body, sharp uterus, control wound.

Myrrha:

[nature and flavor] are bitter, pungent, flat.

[function] is antibacterial, antimicrobial, antiinflammatory, convergence, tool balosam speciality, deodorization, flatulence of dispelling, sterilization, diuresis, stimulate the menstrual flow, reduce phlegm, antifungal, excitation, sharp stomach, urge antiperspirant, mend body, sharp uterus, control wound, to ripe dry and cracked to take off coarse skin helpful.

The Radix Angelicae Dahuricae:

[nature and flavor] are pungent, and temperature enters lung, spleen, stomach warp;

[effect] controls headache, supraorbital bone pain, toothache, and cold-damp is suffered from abdominal pain, skin pruritus, scabies.Expelling wind and cold, understand things pain-stopping, evacuation of pus of invigorating blood circulation, granulation promoting pain relieving, dampness leukorrhagia stopping.For mastalgia, swell and ache, have a headache, have a toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.Modern pharmacological research proves that the Radix Angelicae Dahuricae also has antiinflammatory, antipyretic-antalgic, active eliminating stagnation, can be used for controlling the effects such as mammary gland caking with other Chinese Medicine and Clavicular.

Radix Et Rhizoma Rhei:

[meridian distribution of property and flavor] bitter in the mouth, cold; Return spleen, stomach, large intestine, liver, pericardium channel.

[function cures mainly] purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gums swells.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood hemorrhage is had for heat in blood.

Pericarpium Citri Reticulatae:

[meridian distribution of property and flavor] is bitter, pungent, temperature; Return lung, spleen channel.

[function cures mainly] regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

Scorpio:

[effect] medicine for calming liver and calming endopathic wind; Dispel-wind drug; Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain

[meridian distribution of property and flavor] is pungent, flat; Poisonous.Return liver Channel.

[substantially curing mainly] infantile convulsion; Tic spasm; Middle air port ; Hemiplegia; Tetanus; Rheumatoid arthritis stubborn; Migraine and general headache; Toothache; Deaf; Carbuncle sore; Scrofula sucutaneous nodule; venom; Burn; rubella; Stubborn dermatitis

Radix Saposhnikoviae:

[meridian distribution of property and flavor] acrid in the mouth, sweet, slightly warm in nature; Return bladder, liver, spleen channel.

[function] expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.Diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.

Bee pollen:

Bee pollen is the male sex-cell in flowering plant stamen, and it not only carries the hereditary information of life, and contains and breed the necessary complete nutrients matter of new life, be plant produce a male heir to continue the family line basic, the source of heat energy.Bee pollen is the concentrate that the nutritious material be worth with drug effect forms, and it contains protein, carbohydrate, mineral, vitamin and other active substance.Bee pollen is fabulous natural nutrient food, is also a kind of desirable tonic simultaneously, and has certain medical function.

The health-care effect of bee pollen

(1) strengthen human body comprehensive immunologic function: pollen polysaccharide energy activating macrophage engulf activity, improve human disease resistance.

(2) anti-aging, beautification function: bee pollen belongs to the cosmetics of trophism, the VE in pollen, superoxide dismutase(SOD), the composition such as selenium can moisten nutrition skin, recovers the elasticity of skin and bright and clean.In pollen inositolcan make poliosis blackening, alopecia is life gradually, keeps hair pitch-black beautiful.

(3) brain cardiovascular disease is prevented and treated: the flavone compound in pollen can effectively be removed in blood vessel wall fatdeposition, thus play vessel softening and blood fat reducing.

(4) lose weight: take bee pollen and can absorb enough nutrition, cause satietion.Meanwhile, the fat of the lecithin incendivity surplus in pollen, reaches the object of fat-reducing.

(5) regulate the intestines and stomachfunction: pollen has many sterilization components, can kill escherichia coli etc., and can prevent treating constipation.

(6) hepatoprotective: the flavone compound in pollen can prevent the deposition of fat on liver equally.

(7) nervous system regulation, hypnotic.

(8) auxiliary treatment other diseases: pollen to anemia, diabetes, Improving memory power, climacteric obstacle etc. have better effects.

(9) prostatosis is prevented and treated: pollen is prostatitic jinx, with Pollen Brassicae campestris, pollen of Semen Fagopyri Esculenti best results.Active drug-QIANLIEKANG that China controls prostatosis take pollen as raw material.

(10) gastrointestinal function is regulated: pollen has many sterilization components, can kill escherichia coli etc., and can prevent treating constipation.

(11) hepatoprotective: the flavone compound in pollen can prevent the deposition of fat on liver equally.

(12) regulate nervous system, hypnotic.

(13) auxiliary treatment other diseases: pollen to anemia, diabetes, Improving memory power, climacteric obstacle etc. have better effects.

To the effect of habitual constipation

Habitual constipation is common disease, and bring to patient and bear at heart, to middle-aged and elderly people, constipation misery is a kind of potential risk factor, the person that especially has Cardial or cerebral vascular diseases, often because of constipation, straining at stool and meeting accident.Therefore, treatment constipation, makes defecation smooth, and to the health of people, to prevent an accident be very important.Bee pollen treatment anti-constipation effect is significant, and effective percentage reaches 95%, and curative effect shows as infrequent defecation and shortens, and defecation time obviously shortens, and feces softens, and just measures increase.Treatment affects by age, sex, constipation history and treatment history hardly, does not occur the side effect such as diarrhoea during treatment.

To the effect of anti-ageing life-prolonging

Normal edible bee pollen person can be long-lived, and this is the fact of history identity.The accumulation of lipofuscin in the brain cell of human body, can affect the normal function of brain cell.Lipofuscin content increases, and can cause cellular atrophy and death.After edible bee pollen, each system enhancement of health, dispels brown pigmentfunction is strengthened, and body aging process slows down, and brain memory power significantly improves, and testosterone, estradiol level increase, and the body constitution of old people improves naturally, and senile plaque reduces gradually and disappears.

In bee pollen, contained selenium can reduce over the formation of oxide in addition, thus plays anti-aging effects.This is also take one of major reason that bee pollen can be long-lived.

Antitumaous effect

Bee pollen has the effect of obvious anti-cancer tumor suppressor.

In pollen saccharidetotal content is 25 ~ 40%, saccharide A wide selection of colours and designs.Comprise monosaccharide, oligosaccharide and polysaccharide etc.Wherein have most the pollen polysaccharide of DEVELOPMENT PROSPECT, it has very strong immunocompetence, has obvious anti-cancer efficacy.

Slight pollen not only contains the hereditary information of life, but also contains the complete nutrients matter breeding a new life.Therefore, many experts think in the world: pollen is the health food of unique complete nutrition found so far in the world!

Hemopoietic function

Bee pollen has specially good effect to treatment anemia, a large amount of this respect reports is just had abroad as far back as the sixties in 20th century, mainly be used as treatment iron deficiency (ferrum food), lack vitamin (vitamin food) property anemia disorder anemia, adult patients is bee pollen (bee pollen food) 15 ~ 20 grams daily, child's (infant foods) patient daily about 10 grams, check after two months, erythrocyte can increase by 25% ~ 30%, and hemoglobin increases by more than 15%.Patient's appetite strengthens, sleep (sleep food) improvements, free movement of the bowels, health are relaxed and comfortable, body weight increases, and headache, the disappearance of weak phenomenon, have rosy cheeks.Adhere to taking two courses for the treatment of, hemoglobin can be made to recover normal, and Anemia disappears completely.

Research report proves, bee pollen is conducive to impelling the bone marrow restore funcitons be as early as possible wound, and can accelerate the reparation of hemopoietic tissue and the new life of hemocyte, and running well to guarantee hemopoietic function plays positive effect.Wang Weiyi is had a mind to mice by radiation hemopoietic systemcause the damage of equal extent, rear section clothes with bee pollen, another part takes routine feedstuffin contrast.Carry out after 10 days observing and weighing, find that the growth of taking bee pollen is normal, most health ( health food) to exist and spirit is good, on average every body weight increases by 1.4 ~ 4.3 grams; Matched group is Mortality then, and surplus nonresident portion also lethargy, is off one's feed, and weight average declines 1.1 ~ 3 grams, demonstrates the peculiar effect of bee pollen to hemopoietic function.

To urinary system

Bee pollen is the jinx of prostatosis, right chronic prostatitis, prostatic hyperplasia, prostatic function be disorderly etc., and disease has significant therapeutic effect.Utilize the QIANLIEKANG PIAN of bee pollen (bee pollen food) development and production both at home and abroad, the medicine such as prostate ties up him, Xi Erni sheet, be all the ideal medicament for the treatment of prostate class disease.

Bee pollen all has good curative effect to male's (male's food) sexual impotence, sexual dysfunction and azoospermia, infertility etc., and comprehensively combine menoxenia, dysmenorrhea, menopause, nause gravidarum vomiting, climacteric (climacteric food) and infertility etc. also has obvious auxiliary curative effect.This

Outward, diabetics long-term taking bee pollen is evident in efficacy.It is reported, application bee pollen treatment non insulin dependent debates mellitus patient 30 example, has 29 examples evident in efficacy, invalid 1 example.Right insulin dependent diabetes mellitus (IDDM)(dieletic foodstuff), takes insulin and bee pollen and use, also has collaborative hypoglycemic effect.

Enhancing immunity

Modern medicine is thought, causes the reason of human diseases to have two, and one is that Human Physiology desired nutritional composition lacks or uneven, and two is that antibacterial and other microorganism are to the infection of human body.Natural spp. pollen (bee pollen food) (bee pollen product) comprehensive nutrition, can overcome the various disorders occurred in human metabolism, thus enhancing immunity (immunity product, immunity information), this is the secret that bee pollen can control various diseases.Food, medicine and the cosmetics such as " QIANLIEKANG PIAN " on market, " beautiful skin care king " are all that raw material is made with bee pollen.

Health care (health food) effect of bee pollen mainly contains:

1. strengthen human body comprehensive immunologic function: pollen polysaccharide energy activating macrophage engulf activity, improve human disease resistance.

2. anti-aging, beauty treatment (beauty food) effect: the compositions such as bee pollen belongs to the cosmetics of trophism, the VE in pollen, superoxide dismutase (COD) can moisten nutrition skin, recovers elasticity and the gloss of skin (skin products, skin information).Inositol in pollen can make poliosis blackening, and alopecia is life gradually, keeps hair pitch-black beautiful.

Rhizoma Bolbostematis: Bulbus Fritillariae Uninbracteatae is herbaceos perennial, its bulbhyoscine, has the merit of relieving cough and resolving phlegm, heat clearing away eliminating stagnation.

Cold in nature, bitter in the mouth, has stronger antiinflammatory, antiviral and resists tumoreffect, normal to use with other heat-clearing and toxic substances removing medicine compatibilities, treat breast disease, tuberculosis, skin swell the disease such as rotten.

[property of medicine]: be slightly cold

[flavour of a drug]: bitter

[return through]: return lung, spleen channel

[function]: eliminating stagnation, detumescence, removing toxic substances.

[curing mainly]: for acute mastitis, scrofula; Mastitis, lymphoid tuberculosis, chronic lymphadenitis, hypertrophic rhinitis.

Detailed description of the invention:

Embodiment 1, formula:

Squama Manis 0.1mg, Spina Gleditsiae 0.02mg, Radix Angelicae Sinensis 1mg, Radix Glycyrrhizae 0.1mg, Flos Lonicerae 1mg, Radix Paeoniae Rubra 1mg, Olibanum 1mg, Myrrha 1mg, Radix Angelicae Dahuricae 1mg, Radix Et Rhizoma Rhei 1mg, Pericarpium Citri Reticulatae 1mg, Scorpio 1mg, Radix Saposhnikoviae 1mg, bee pollen 0.1mg, Rhizoma Bolbostematis 1mg;

Each serving 4 grams, twice on the one.Warm water takes.

Points for attention: avoid pungent, oily raw meat, raw and cold food.

Embodiment 2, formula:

Squama Manis 0.2mg, Spina Gleditsiae 0.03mg, Radix Angelicae Sinensis 2mg, Radix Glycyrrhizae 0.2mg, Flos Lonicerae 2mg, Radix Paeoniae Rubra 2mg, Olibanum 2mg, Myrrha 2mg, Radix Angelicae Dahuricae 2mg, Radix Et Rhizoma Rhei 2mg, Pericarpium Citri Reticulatae 2mg, Scorpio 2mg, Radix Saposhnikoviae 2mg, bee pollen 0.2mg, Rhizoma Bolbostematis 2mg.

B, medicinal residues add 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, filters, concentrated, 80-160 order filter, 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.35 extractum, heating and refluxing extraction 2 times, each 30 minutes ~ 45 minutes, extracts active ingredient, 2 extracting solution are merged and is settled into extractum shape, as component 2.

C, by concentrated for above-mentioned two kinds of extractum mixing.

Get above-mentioned enema 100mL ~ 200mL during use, retention enema, pours into 30mL ~ 50mL at every turn at every turn, and inject with No. 12 oxygen catheters and 50mL syringe, insertion depth is 15cm ~ 20cm, 2 ~ 3 times/d, 7d are 1 basic course for the treatment of, each 20min-40min.

Embodiment 3, formula:

Squama Manis 0.5mg, Spina Gleditsiae 0.05mg, Radix Angelicae Sinensis 3mg, Radix Glycyrrhizae 0.5mg, Flos Lonicerae 5mg, Radix Paeoniae Rubra 5mg, Olibanum 5mg, Myrrha 5mg, Radix Angelicae Dahuricae 5mg, Radix Et Rhizoma Rhei 5mg, Pericarpium Citri Reticulatae 5mg, Scorpio 5mg, Radix Saposhnikoviae 5mg, bee pollen 0.5mg, Rhizoma Bolbostematis 5mg.

C, by concentrated for above-mentioned two kinds of extractum mixing.

Embodiment 4, formula:

Squama Manis 0.8mg, Spina Gleditsiae 0.07mg, Radix Angelicae Sinensis 4mg, Radix Glycyrrhizae 0.8mg, Flos Lonicerae 8mg, Radix Paeoniae Rubra 8mg, Olibanum 8mg, Myrrha 8mg, Radix Angelicae Dahuricae 8mg, Radix Et Rhizoma Rhei 8mg, Pericarpium Citri Reticulatae 8mg, Scorpio 8mg, Radix Saposhnikoviae 8mg, bee pollen 0.8mg, Rhizoma Bolbostematis 8mg.

Each serving 4 grams, twice on the one.Warm water takes.

Points for attention: avoid pungent, oily raw meat, raw and cold food.

Embodiment 5, formula:

Squama Manis 0.9mg, Spina Gleditsiae 0.08mg, Radix Angelicae Sinensis 5mg, Radix Glycyrrhizae 0.9mg, Flos Lonicerae 9mg, Radix Paeoniae Rubra 9mg, Olibanum 9mg, Myrrha 9mg, Radix Angelicae Dahuricae 9mg, Radix Et Rhizoma Rhei 9mg, Pericarpium Citri Reticulatae 9mg, Scorpio 9mg, Radix Saposhnikoviae 9mg, bee pollen 0.9mg, Rhizoma Bolbostematis 9mg;

Each serving 4 grams, twice on the one.Warm water takes.

Points for attention: avoid pungent, oily raw meat, raw and cold food.

The all medicines of the present invention share have invigorate blood circulation, detoxicating, softening the hard mass, change knot function;

Adapt to symptom: breast carcinoma, cyclomastopathy, acute mastitis, lump in breast, etc. other position carbuncle.

Pharmacology pharmacodynamic is tested:

1, cumulative toxicity test report

Test method: select 20 healthy mices, female, each 10 of hero, with capsule of the present invention, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, the LD50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.

2, acute toxicity test: give white mouse large enteral dispensing with 200 times of the clinical consumption per day of this product enema, observe 5.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse vagina and damaged skin, there are no irritative response and other untoward reaction.Toxicity test proves, the not toxic effect of this medicine and untoward reaction, clinical practice is safe and reliable

3, to the bacteriostasis of common bacterial strain

Solid process antibacterial action: line on blood ware or ordinary nutrient agar plate so that various test organisms is intensive, punch with 8mm card punch, every hole adds aseptic reagent and is about 0.2ml, cultivate 18 ~ 24 hours at 37 DEG C, observe the size of inhibition zone, for inventive gel agent, judge that its responsive result is as follows:

Bacterial strain	Strain number	100% gel	200% gel	300% gel
					Staphylococcus aureus	M122	--	+++	+++
Staphylococcus albus	M121	-	++++	++++
					Bacillus pyocyaneus	Ps207	-	++	+++
Bacillus proteus	E402	+	++	+++
					Escherichia coli	E100	-	++	++
Bacillus subtilis	63051	+	+++	++
					Diphtheria corynebacterium	C102	+	+++	++++
Diplococcus pneumoniae	M311	-	+++	+++
					Bacillus typhi	E686	++	+++	++++
Paratyphoid bacillus A	50073	++	+++	+
					Bacillus paratyphosus B	50094	+	++	++++
Beta hemolysis streptococcus	M220	++	++++	+++

Antibacterial circle diameter < 9mm., drug resistance-; Antibacterial circle diameter >=10 ~ 14mm, slight sensitive+; Antibacterial circle diameter >=15 ~ 19mm, medium sensitivity ++; Antibacterial circle diameter >=20 ~ 29mm, extremely sensitive +++; Antibacterial circle diameter >=30mm, special extremely sensitive ++++.

Above extracorporeal bacteria inhibitor test shows, this product truly has obvious inhibitory action to common antibacterial.

4. hypersensitive test:

Get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.Get enema 0.1g of the present invention and be applied to unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, at back, the same area smeared this product 0.1g, at once observes after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.

Pharmacological experiment

Get capsule of the present invention, drugs compared is some, mice, rabbit is provided by biology department of Shandong University.

1, medicine group mice charcoal end propelling rate of the present invention compares with Normal group and presents remarkable inhibitory action; Can the intestinal smooth muscle spasm that causes of antagonism neostigmine, resist the intestinal function caused by atropine and suppress, play the effect regulating intestinal function; Blood D-xylose concentration is apparently higher than Normal group; Of the present invention group of suppression ratio to rabbits infestines smooth muscle, antagonistic rate all have significant difference apparently higher than matched group; Mouse death rate in 3 hours all makes moderate progress;

Medicine group of the present invention can obviously antagonism intestinal function be hyperfunction, improves intestinal function and suppresses, play and regulate intestinal function effect, has spasmolytic and the effect promoting intestinal absorption; Rehabilitation effect is had to spleen-deficient mice; Mouse monokaryon macrophage phagocytic function, enhancing human body immunity can be promoted.

Table 1 medicine of the present invention is on the impact (X ± SD) of small intestine movement of mice propulsion functions

Group	n	Dosage (g/kg)	Intestinal propulsive rate (%)
				Normal group	10	0	72.56±9.74
Paddy ginseng intestinal peace group	10	0.70	67.72±11.45
				Medicine low dose group of the present invention	10	0.62	70.07±11.24
Dosage group in medicine of the present invention	10	1.24	65.92±9.57*
				Medicine high dose group of the present invention	10	1.86	61.72±6.31**

* P < 0.05**P < 0.01 compares with Normal group

Experimental result shows: in medicine of the present invention, dosage group has demonstrated the inhibitory action to intestinal propulsion, high dose group then has significant differences (P < 0.01) compared with Normal group, medicine of the present invention advances small intestine movement of mice as can be seen here obvious inhibitory action, and strengthens to some extent along with the increase inhibitory action of dosage.

Impact (X ± SD) n=12 that table 2 medicine of the present invention is hyperfunction on neostigmine induced mice intestinal propulsion

Group	Dosage (g/kg)	Intestinal propulsive rate (%)
			Normal group	0	69.18±8.53
Model control group	0	78.22±8.75△
			Paddy ginseng intestinal peace group	0.70	70.27±8.06
Medicine low dose group of the present invention	0.620	73.21±11.45
			Dosage group in medicine of the present invention	1.24	68.54±9.22*
Medicine high dose group of the present invention	1.86	66.68±6.67**

△ P < 0.05, compares * P < 0.05**P0.01 and compares with model control group with Normal group

Result shows: mice is after injection neostigmine, its Intestinal propulsive rate has obvious rising (p < 0.05), after drug administration of the present invention, each administration group mouse small intestine propelling rate all has certain decline, wherein, heavy dose of group compares with model control group significant difference (P < 0.05, p < 0.01), and medicine of the present invention has obvious antagonism to neostigmine induced mice intestinal propulsion is hyperfunction as can be seen here.

The impact (X ± SD, n=10) that table 3 medicine of the present invention suppresses atropine induced mice intestinal propulsion

△ P < 0.05, compares * * P < 0.01 and compares with model control group with Normal group

Atropine makes the intestinal propulsion of mice be suppressed (atropine group compares with Normal group significant difference p < 0.05), medication result shows medicine of the present invention can resist atropinic small intestinal inhibitory action, its Intestinal propulsive rate is apparently higher than atropine group (p < 0.01), and medicine of the present invention suppresses there is obvious antagonism to atropine induced mice intestinal propulsion as can be seen here.

Clinical data

Breast carcinoma refers to the malignant tumor in breast portion.Be equivalent to the breast carcinoma of doctor trained in Western medicine.Be characterized in that painless, nothing heat, the constant and scleroid lump of color of the leather appear in breast portion, what push away does not move, rough, uneven, or nipple hemorrhage, and late period festers, recessed as general lotus.It is one of modal malignant tumor of women.My institute uses treatment by Chinese herbs breast carcinoma enteritis to achieve certain curative effect in March, 2010 ~ 2013 year July, is now reported as follows.

1 data and method

1.1 physical data: breast carcinoma patient totally 200 examples selecting my institute's diagnosis and treatment of in March, 2010 ~ 2013 little period in year July, all meet the sick diagnostic criteria of Chinese breast carcinoma in 2000.

1.2 Therapeutic Method: select the present composition to take orally or coloclysis

1.3 efficacy determinations: according to the sick curative effect determinate standard of breast carcinoma of Chinese breast carcinoma sick diagnoses and treatment scheme revision

Effective: recover normal in treatment 100d, General Symptoms disappears;

Effective: be clearly better in treatment 100d, General Symptoms improves;

Invalid: in treatment 100d, General Symptoms is without improvement, even worsens.

2 results

Two groups of comparitive study: observation group's total effective rate 96.1%; Apparently higher than matched group total effective rate 76.3%, through statistical procedures, two groups of total effective rate comparing differences have statistical significance (P<0.01), in table 1.

A table 1 liang group therapeutic effect compares (example)

Group	Number of cases	Effective	Effectively	Invalid	Total effective rate (%)
						Treatment group	128	102	21	5	96.09
Matched group	72	37	18	17	76.39

Note: compare with matched group, P<0.01.

Claims

1. effectively treat a Chinese medicine composition for breast carcinoma, it is characterized in that, be made up of the raw material of following weight portion:

Squama Manis 0.1-0.9 part, Spina Gleditsiae 0.02-0.08 part, Radix Angelicae Sinensis 1-5 part, Radix Glycyrrhizae 0.1-0.9 part, Flos Lonicerae 1-9 part, Radix Paeoniae Rubra 1-9 part, Olibanum 1-9 part, Myrrha 1-9 part, Radix Angelicae Dahuricae 1-9 part, Radix Et Rhizoma Rhei 1-9 part, Pericarpium Citri Reticulatae 1-9 part, Scorpio 1-9 part, Radix Saposhnikoviae 1-9 part, bee pollen 0.1-0.9 part, Rhizoma Bolbostematis 1-9 part.

2. the Chinese medicine composition of a kind of effective treatment breast carcinoma according to claim 1, is characterized in that, be made up of the raw material of following weight portion:

3. the Chinese medicine composition of a kind of effective treatment breast carcinoma according to claim 1, is characterized in that, be made up of the raw material of following weight portion:

4. the Chinese medicine composition of a kind of effective treatment breast carcinoma according to claim 1-3 any one, is characterized in that, the dosage form of Chinese medicine composition is capsule, and its preparation process comprises:

5. the Chinese medicine composition of a kind of effective treatment breast carcinoma according to claim 4, is characterized in that, described preparation method, and the extraction of volatile oil contained by Radix Glycyrrhizae, Pericarpium Citri Reticulatae and Flos Lonicerae in step a is steam distillation or supercritical fluid extraction.

6. the Chinese medicine composition of a kind of effective treatment breast carcinoma according to claim 4, is characterized in that, described preparation method, and the method in step b adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.

7. the Chinese medicine composition of a kind of effective treatment breast carcinoma according to claim 1-3 any one, is characterized in that, to be the preparation process of enema be for the dosage form of Chinese medicine composition:

C, by concentrated for above-mentioned two kinds of extractum mixing.

8. the Chinese medicine composition of a kind of effective treatment breast carcinoma according to claim 7, it is characterized in that, in described step b, medicinal residues add 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, filter, concentrated, 80-160 order filters, 6000-10000 rev/min centrifugal after supernatant, through the ultrafiltration post ultrafiltration that the molecular weight that dams is 5000-10000, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.35 extractum, heating and refluxing extraction 2 times, each 30 minutes ~ 45 minutes, extract active ingredient, 2 extracting solution are merged and is settled into extractum shape, as component 2,

9. the Chinese medicine composition of a kind of effective treatment breast carcinoma according to claim 1-3 any one, it is characterized in that, the dosage form of described Chinese medicine composition is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, injection, suppository, plaster, syrup, enema or patch.