CN103652501A - Feed for treating cow mastitis and preparation method thereof - Google Patents
Feed for treating cow mastitis and preparation method thereof Download PDFInfo
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- CN103652501A CN103652501A CN201310722973.1A CN201310722973A CN103652501A CN 103652501 A CN103652501 A CN 103652501A CN 201310722973 A CN201310722973 A CN 201310722973A CN 103652501 A CN103652501 A CN 103652501A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention discloses a feed for treating cow mastitis and a preparation method thereof. The feed comprises the following raw materials: barley, oat, soybean, peanut meal, dry alfalfa powder, shaddock peel, needle mushroom dreg, kelp powder and traditional Chinese medicine additives. The feed for treating the cow mastitis has the following benefits: the feed contains the traditional Chinese medicine additives, and uses heat clearing, poison removal, blood activation, blood stasis removal, painful menstruation relieving and collaterals activation as main treatment principles; the traditional Chinese medicine additives are matched and coacted with other raw materials of the feed, so that the immunity and disease resistance of cows can be improved, and the treatment of the mastitis has the advantages of good treating effect, difficult relapse, low toxic and side effects and no residue; the feed is fitted with external ointment to achieve better treating effect.
Description
Technical field
The present invention relates to field of feed, particularly a kind of feed that is used for the treatment of mastitis for milk cows and preparation method thereof.
Background technology
Mastitis for milk cows is the inflammation of mammary glandular cell and mammary gland interstitial.Cause the pathogen of breast inflammation, approximately 85% is streptococcus, micrococcus scarlatinae etc., and 5% is staphylococcus.Other have tubercle bacillus, Brucella, corynebacterium pyogenes, Escherichia coli, mycoplasma and mould etc.The economic loss that mastitis for milk cows causes is very large, is first that the output of milk reduces, and is secondly that disease breast can not be drunk, and even gives people's communicate illness, and people ' s health is worked the mischief.If mammitis can not be treated in time, often make mastatrophy, milk can not be sold, and even completely loses galactogogue action.Therefore to perform the work that prevents and treats mammitis.
At present, adopt antibiotic therapy mastitis for milk cows, result for the treatment of is undesirable more, and drug tolerant bacteria also can be by milk-born infection to people, in milk cow, residual antibiotic also can bring out human body generation hypersensitivity in addition, and therefore, the non-antibiotic therapy of mastitis for milk cows causes people's concern gradually.
The traditional traditional Chinese medicine of China is conceived to integral body while applying, and emphasizes to regulate allomeric function, improves the premunition of body self.Chinese medicine belongs to natural drug, has antibacterial, anti-inflammatory, is difficult for making pathogenic bacteria to produce the effect that drug resistance and immunity strengthen, and has the feature of safety, efficient, low toxicity, low-residual, can overcome the drawback that a large amount of use antibiotic bring; Chinese herbal medicine has enhancing human body immune function, improve animal anti-stress, anti-disease ability, improve the multiple efficacies such as breeding performonce fo animals, and have no drug resistance, noresidue, toxic and side effect be little, demonstrates unique advantage aspect livestock and poultry cultivation.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of feed that is used for the treatment of mastitis for milk cows and preparation method thereof, adopts the feed contain Chinese medicine additive to have advantages of that curative effect is high, toxic and side effect is little, noresidue, do not develop immunity to drugs, non-environmental-pollution, and can increase Abwehrkraft des Koepers and short treating period the treatment of mastitis for milk cows.
In order to realize foregoing invention object, the invention provides a kind of feed that is used for the treatment of mastitis for milk cows, it is characterized in that, described feed comprises following raw material: barley, oat, soybean, peanut meal, clover dry powder, pomelo peel, golden mushroom slag, Kelp Powder and Chinese medicine additive.
Described feed is comprised of the raw material of following parts by weight: barley 50-70 weight portion, oat 40-60 weight portion, soybean 30-50 weight portion, peanut meal 20-30 weight portion, clover dry powder 20-30 weight portion, pomelo peel 10-15 weight portion, golden mushroom slag 10-15 weight portion, Kelp Powder 10-15 weight portion and Chinese medicine additive 5-17 weight portion.
Described feed is comprised of the raw material of following parts by weight: barley 55-65 weight portion, oat 45-55 weight portion, soybean 35-45 weight portion, peanut meal 23-25 weight portion, clover dry powder 22-25 weight portion, pomelo peel 10-15 weight portion, golden mushroom slag 10-15 weight portion, Kelp Powder 10-15 weight portion and Chinese medicine additive 9-17 weight portion.
Described Chinese medicine additive comprises following raw medicinal material: the Radix Astragali, Radix Codonopsis, finelydivided phtheirospermum root, Radix Angelicae Sinensis, bitter leaves, notopterygium root, Radix Isatidis, Ligusticum wallichii, meropodium pearl, Boston ivy, orange peel, bodhi perfume, Radix Glycyrrhizae, wilsonii, akebi, rhizoma cyperi, donkey-hide gelatin, cactus, crape myrtle, dried orange peel, Gorgon fruit, the membrane of a chicken's gizzard, Divine Comedy and hawthorn.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, finelydivided phtheirospermum root 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, bitter leaves 15-25 weight portion, notopterygium root 10-25 weight portion, Radix Isatidis 10-16 weight portion, Ligusticum wallichii 13-20 weight portion, meropodium pearl 10-15 weight portion, Boston ivy 10-15 weight portion, orange peel 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, wilsonii 10-20 weight portion, akebi 10-15 weight portion, rhizoma cyperi 10-15 weight portion, donkey-hide gelatin 10-15 weight portion, cactus 10-15 weight portion, crape myrtle 10-20 weight portion, dried orange peel 10-20 weight portion, Gorgon fruit 10-15 weight portion, the membrane of a chicken's gizzard 10-15 weight portion, Divine Comedy 15-20 weight portion and hawthorn 10-15 weight portion.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, finelydivided phtheirospermum root 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, bitter leaves 18-22 weight portion, notopterygium root 15-20 weight portion, Radix Isatidis 12-14 weight portion, Ligusticum wallichii 15-18 weight portion, meropodium pearl 12-14 weight portion, Boston ivy 12-14 weight portion, orange peel 13-18 weight portion, the fragrant 16-18 amount part of bodhi, Radix Glycyrrhizae 15-18 weight portion, wilsonii 13-18 weight portion, akebi 11-14 weight portion, rhizoma cyperi 12-14 weight portion, donkey-hide gelatin 11-14 weight portion, cactus 11-14 weight portion, crape myrtle 12-18 weight portion, dried orange peel 12-17 weight portion, Gorgon fruit 11-14 weight portion, the membrane of a chicken's gizzard 11-14 weight portion, Divine Comedy 17-19 weight portion and hawthorn 12-14 weight portion.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portions, Radix Codonopsis 15 weight portions, finelydivided phtheirospermum root 13 weight portions, Radix Angelicae Sinensis 15 weight portions, bitter leaves 20 weight portions, notopterygium root 17 weight portions, Radix Isatidis 13 weight portions, Ligusticum wallichii 17 weight portions, meropodium pearl 13 weight portions, Boston ivy 13 weight portions, orange peel 15 weight portions, fragrant 17 amounts part of bodhi, Radix Glycyrrhizae 16 weight portions, wilsonii 15 weight portions, akebi 12 weight portions, rhizoma cyperi 13 weight portions, donkey-hide gelatin 12 weight portions, cactus 13 weight portions, crape myrtle 15 weight portions, dried orange peel 14 weight portions, Gorgon fruit 13 weight portions, the membrane of a chicken's gizzard 13 weight portions, Divine Comedy 18 weight portions and hawthorn 13 weight portions.
Described Chinese medicine additive also comprises: ant, radix bupleuri, glossy ganoderma and rhodiola root.
Described feed is comprised of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, finelydivided phtheirospermum root 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, bitter leaves 15-25 weight portion, notopterygium root 10-25 weight portion, Radix Isatidis 10-16 weight portion, Ligusticum wallichii 13-20 weight portion, meropodium pearl 10-15 weight portion, Boston ivy 10-15 weight portion, orange peel 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, wilsonii 10-20 weight portion, akebi 10-15 weight portion, rhizoma cyperi 10-15 weight portion, donkey-hide gelatin 10-15 weight portion, cactus 10-15 weight portion, crape myrtle 10-20 weight portion, dried orange peel 10-20 weight portion, Gorgon fruit 10-15 weight portion, the membrane of a chicken's gizzard 10-15 weight portion, Divine Comedy 15-20 weight portion, hawthorn 10-15 weight portion, ant 10-16 weight portion, radix bupleuri 15-20 weight portion, glossy ganoderma 10-15 weight portion and rhodiola root 10-15 weight portion.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, finelydivided phtheirospermum root 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, bitter leaves 18-22 weight portion, notopterygium root 15-20 weight portion, Radix Isatidis 12-14 weight portion, Ligusticum wallichii 15-18 weight portion, meropodium pearl 12-14 weight portion, Boston ivy 12-14 weight portion, orange peel 13-18 weight portion, the fragrant 16-18 amount part of bodhi, Radix Glycyrrhizae 15-18 weight portion, wilsonii 13-18 weight portion, akebi 11-14 weight portion, rhizoma cyperi 12-14 weight portion, donkey-hide gelatin 11-14 weight portion, cactus 11-14 weight portion, crape myrtle 12-18 weight portion, dried orange peel 12-17 weight portion, Gorgon fruit 11-14 weight portion, the membrane of a chicken's gizzard 11-14 weight portion, Divine Comedy 17-19 weight portion, hawthorn 12-14 weight portion, ant 12-14 weight portion, radix bupleuri 16-19 weight portion, glossy ganoderma 11-13 weight portion and rhodiola root 11-14 weight portion.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portions, Radix Codonopsis 15 weight portions, finelydivided phtheirospermum root 13 weight portions, Radix Angelicae Sinensis 15 weight portions, bitter leaves 20 weight portions, notopterygium root 17 weight portions, Radix Isatidis 13 weight portions, Ligusticum wallichii 17 weight portions, meropodium pearl 13 weight portions, Boston ivy 13 weight portions, orange peel 15 weight portions, fragrant 17 amounts part of bodhi, Radix Glycyrrhizae 16 weight portions, wilsonii 15 weight portions, akebi 12 weight portions, rhizoma cyperi 13 weight portions, donkey-hide gelatin 12 weight portions, cactus 13 weight portions, crape myrtle 15 weight portions, dried orange peel 14 weight portions, Gorgon fruit 13 weight portions, the membrane of a chicken's gizzard 13 weight portions, Divine Comedy 18 weight portions, hawthorn 13 weight portions, ant 13 weight portions, radix bupleuri 17 weight portions, glossy ganoderma 12 weight portions and rhodiola root 13 weight portions.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, mixes all raw medicinal materials in proportion, is ground into 100 order～200 object powder, add the water with respect to 3～5 times of mixture qualities, at the temperature of 90 ℃～100 ℃, decoct 30 minutes～1 hour, decoction liquor is filtered, and obtains the first filtered fluid and filter residue;
Second step, the filter residue that the first step is obtained adds the water with respect to 1～3 times of first step mixture quality, at the temperature of 90 ℃～100 ℃, decocts 30 minutes～1 hour, and decoction liquor is filtered, and obtains the second filtered fluid;
The 3rd step, merges the first filtered fluid and the second filtered fluid, and reduced pressure concentration is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer dry, guarantee that EAT is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, are ground into 200 order～400 orders subsequently, obtain Chinese medicine additive powder.
In order better to realize foregoing invention object, the invention provides a kind of preparation method who is used for the treatment of the feed of mastitis for milk cows, described preparation method comprises the following steps:
(1) broken step: take by weight corn, wheat, millet, oat, alfalfa meal and honey skin of beancurd, drop into pulverizer and carry out Crushing of Ultrafine, cross 2.0mm sieve after pulverizing;
(2) batching step: take salt, vitamin D and Chinese medicine additive according to parts by weight, pulverize the fine powder obtaining mix with step (1), drop into mixer, mix, incorporation time is 30-60s;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 85 ℃, and its gelatinization degree is reached more than 90%.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: feed of the present invention contains Chinese medicine additive, take clearing heat and detoxicating, promoting blood circulation and removing blood stasis, dysmenorrhoea is active is primary treatment principle, cooperatively interact with other feedstuffs, acting in conjunction, not only can improve immunity and the resistance against diseases of milk cow, to the treatment of mammitis there is good effect, be difficult for recurrence, toxic and side effect is little, noresidue; Wherein, feed formulation medicinal external emulsifiable paste of the present invention is used, and result for the treatment of is more excellent.
The specific embodiment
Mastitis for milk cows symptom is the inflammation of breast essence, interstitial.The cause of disease is many by due to mechanical irritation, pathogenic microorganism immersion and the damage of chemicals rationality.1. environmental management factor: environmental condition is as muddy in cowshed, ox bed and sports ground can't bear, and around incrustation is too many for ox body and breast, and sanitary condition is too poor, temperature too high (more than 36 ℃) or too low (5 ℃ are following) etc.The condition of milking does not meet lactation physiological requirement, as too high in negative pressure of vacuum, too low, and unsuitable scouring breast and embarkation are milked.2. pathogenic infection: up to the present, people have isolated 150 kinds of pathogenic microorganisms from cow mammary gland tissue, and modal have 23 kinds, and wherein bacterium is 14 kinds, 2 kinds of mycoplasmas, 7 kinds, fungi and virus.What wherein the incidence of disease was the highest is staphylococcus aureus, Escherichia coli, streptococcus, and mycoplasma, the fungus-caused mammitis incidence of disease rise year by year in recent years.3. ox oneself factor: contain phase or the too high milk cow of milk production in lactation, body energy is in negative balance resistance, aged ox, polyembryony time ox relative incidence rate are high.4. Secondary cases factor: the author finds the babesiasis of milk cow in clinical treatment in recent years, also can become the paathogenic factor of mastitis for milk cows, and treatment is got up also very difficult.There is again PNI also can cause occurring mammitis.For this reason, after being made a definite diagnosis, Secondary cases mammitis first should control protopathy.
Mastitis for milk cows can be divided into serosity mammitis, fiber disposition catarrh mammitis, suppurative mammitis, hemorrhagic mammitis, gangrenous mastitis and recessive mastitis.Clinic mastitis: be the inflammation of breast interstitial, essence or interstitial parenchymal tissue.It is characterized in that milk sex change, breast tissue present swelling to some extent, warm and pain.Different with coincident with severity degree of condition according to course of disease length, can be divided into the most acute, acute, subacute and chronic mastitis.The most acute: suddenly, development is rapid, the multiple 1 Ge Ru district of being born in morbidity; Recessive mastitis: claim again Subclinical mammitis.For a kind of mammitis without clinical symptoms performance.It is characterized in that breast and milk are abnormal as seen without naked eyes, yet milk changes on physicochemical property, bacteriology.Concrete manifestation pH value more than 7.0, is meta-alkalescence; In breast, there are newborn piece, floccule, fiber; Sodium chloride content is more than 0.14%, somatic number 500,000/more than mL, bacterial population and electric conductivity value increase; Chronic case: because breast tissue is gradual inflammatory process, lactation acinus wrecks in a big way, breast tissue generation fibrillatable, often causes mastatrophy and induration of breast.
Chinese veterinarian's traditional theory thinks, mammitis is acute mastitis, is phlegm, wet, gas, blood stasis knot is loose and be scorching.Because feeding and management is not good at, sleeping damp and hot ground, steams on damp and hot poison gas for a long time, infringement breast; Or because of hyperpyrexia of stomach, stagnation of QI due to depression of the liver, newborn network loses smooth so that breast qi and blood stagnation, stasis and raw carbuncle is swollen; Or because calf inhales breast, milk being stagnated, breast turgors etc. are former thereby cause this disease.Therefore, that the present invention be take is clearing heat and detoxicating, dredging collateral is invigorated blood circulation, swelling and pain relieving, active logical breast are principle of reatment, a kind of feed that is used for the treatment of mastitis for milk cows that contains Chinese medicine additive is provided, and Chinese medicine additive comprises: the Radix Astragali, Radix Codonopsis, finelydivided phtheirospermum root, Radix Angelicae Sinensis, bitter leaves, notopterygium root, Radix Isatidis, Ligusticum wallichii, meropodium pearl, Boston ivy, orange peel, bodhi perfume, Radix Glycyrrhizae, wilsonii, akebi, rhizoma cyperi, donkey-hide gelatin, cactus, crape myrtle, dried orange peel, Gorgon fruit, the membrane of a chicken's gizzard, Divine Comedy and hawthorn.
Wherein, the pharmacological property of each raw medicinal material is as follows:
The Radix Astragali: take qi-restoratives as main, energy invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, expelling pus and promoting granulation.For insufficiency of vital energy and blood, sore cave in, purulence becomes not burst or burst and do not hold back person for a long time.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration, i.e. the abscess suppuration myogenic of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and can strengthen the immunologic function of body, therefore can also be for preventing the generation of some infectious disease.< < book on Chinese herbal medicine meets former > > to carry: " all void of Radix Astragali energy tonifying five zang organs, controls arteries and veins string spontaneous perspiration, rushes down yin fire, removes lung heat, losslessly sends out, and has sweat to stop." be the good medicine of promoting resistance and defence disease.
Radix Codonopsis: property is flat, sweet, the micro-acid of taste.Return spleen, lung channel.Tonifying middle-Jiao and Qi, invigorating the spleen benefit lung.For a little less than the spleen deficiency syndrome of the lung, the palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst.The just > > of < < book on Chinese herbal medicine carries: Radix Codonopsis power energy tonifying spleen nourishing the stomach, and moistening lung is promoted the production of body fluid, gas in tendon fortune, this is very mutually not far away with ginseng.Its outstanding valuable person, invigorating the spleen fortune and not dry, grows stomach-Yin and wet, and moistening lung and do not violate is cold and coolly nourished blood and is not partially grown greasyly, inspires clear sun, gas in vibration, and without just dry fraud.Radix Astragali tonifying Qi, can rise enriching spleen-QI, can admittedly show by beneficial lung again.Radix Codonopsis tonifying Qi, can only invigorating the spleen tonifying Qi, and without the power of solid table, but Radix Codonopsis can also nourishing generate fluid, and the Radix Astragali is without the effect of promoting the production of body fluid, the double energy of Radix Astragali Li Shui, and Radix Codonopsis is without Li Shui effect.This two tastes medicine share can tonifying middle-Jiao and Qi, improves resistance.
Finelydivided phtheirospermum root: property is flat, taste is arduous.Function cures mainly: mental-tranquilization, hemostasis.Control and have a weak heart, palpitaition, cough blood-stained sputum.Clearing heat and detoxicating, mental-tranquilization, pain relieving.Be used for having a weak heart, palpitaition, cough, blood-stained sputum, abscess of throat, fracture; Snake, dog bite are controlled in external application.
Radix Angelicae Sinensis: taste is sweet and weigh, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting circulation of blood, and bowl spares has, in row, has benefit, really the gas medicine in blood, the also panacea in blood.About mending to mend of assistant, thus can support nutrition blood, tonifying Qi production of sperm, five viscera settling, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack, therefore the pain defaecation of dispelling, relieving rigidity of muscles and joints, controls contraction, paralysis, the card such as dry, puckery.Seek void and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and table is not held back person, and assistant, with rheum officinale and so on, can be shown again admittedly.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Bitter leaves: bitter; Cold in nature, function cures mainly: clearing heat and detoxicating; Wines used as antirheumatic; Invigorate blood circulation.Main furunculosis carbuncle is swollen; Abscess of throat; Mange; Hemorrhoid; Snake bite; Arthralgia due to wind-dampness; Traumatic injury.
Notopterygium root: return bladder; Kidney channel.Nature and flavor: taste is pungent; Bitter; Warm in nature.Loose exterior cold; Wines used as antirheumatic; Profit joint; Pain relieving.Loose exterior cold, wines used as antirheumatic, sharp joint.The chill that cures cold, has a headache lossless, wind-cold-dampness arthralgia, a strong muscular contracture, joint ache, geomantic omen edema, skin sore.For impotence and seminal emission, enuresis frequent micturition, waist knee crymodynia, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External application curing vitiligo, alopecia areata.Induce sweat loose cold, expelling wind and eliminating dampness, pain relieving.Be used for catching cold, fever with aversion to cold, the cards such as headache bodily pain.This product has stronger expelling cold, eliminating and analgesic effect.Often be equal to use with windproof, the root of Dahurain angelica, the root of Chinese wild ginger, as Notoptreygium Decoction of Nine Ingredients.Podomere pain, aching pain in should and back due to attacking for wind-cold damp pathogen, especially more applicable with upper part of the body pain.This product can be dispeled the wind and be won temperature, eliminating cold to stop pain.Often with windproof, same use, as juanbi decoction.< < property of medicine opinion > >: " control harmful wind, aphonia in silence, the blood leprosy of itching, hands and feet caused by paralysis, the askew heresy of actinal surface, stupid numbness all over more." < < Japan hanako materia medica > >: " and control a wind cutting gas, muscles and bones fist contraction, four limbs are thin bad, head revolves the red pain of eyes and mass located in the upper or lower abdomen aqueous vapor, general debility, deficient cold air, joint ache, tonneau the five internal organs." < < pearl sac > >: " Taiyang channel headache, removes all arthralgias, also can warm courage." the smart > > that wants of < < product remittance: " main all joints being painful all over, flesh table Bafeng thief is evil, removes new and old rheumatism, arranges slough subcutaneous ulcer sore." < < Essentials of Materia Medica > >: " purging the liver of pathogenic fire gas, searches liver wind, controls evils of wind and weness blended to attack the body, herbal classic (sun) headache, governor vessel is disease, back rigidity and fainting, the soft convulsion of tonic convulsion, aphasia from apoplexy, head revolves hot eyes." < < can approximately cure mirror > >: " control heresy and close the loathing of cold, high fever is lossless.”
Radix Isatidis: resisting pathogenic microbes effect: Radix Isatidis has inhibitory action to various bacteria.Infusion has inhibitory action in various degree to hay bacillus, staphylococcus aureus, sarcine, Escherichia coli, typhoid bacillus, paratyphosum Bacterium, dysentery (will he, Fu Shi) bacillus, bacillus enteritidis etc.; Acetone leachate also has similar effect, and to hemolytic streptococcus effective (all using agar aperture flat band method).Similar to the bacteriostasis of A type meningococcus and garlic, honeysuckle.The 68-1 of the section strain of infected by influenza PR8Zhu He capital has obvious inhibitory action.In vitro Radix Isatidis is killed leptospiral effect.To cardiovascular effect: these product can make the in vitro rabbit ear and rat lower limb perfusion flow increase, and improve Rabbit Mesentery microcirculation, reduce the blood pressure of Anaesthetic Rabbits, reduce capillary permeability, and mouse cardiac muscle oxygen demand is declined.Suppress platelet aggregation Radix Isatidis the Platelet Aggregation in Rabbits of ADP induction is had to remarkable inhibitory action.From Radix Isatidis, get uridine, hypoxanthine, pyrimidine, salicylic acid etc. the Platelet Aggregation in Rabbits of ATP induction is also all showed to certain inhibition activity, when 0.21mg/kg concentration, its inhibiting rate is respectively 18.2%, 24.2%, 10.8% and 20%.Detoxication: for dog, Radix Isatidis, coptis powder and black false hellebore, with clothes (each 2.0g/kg), can be separated black false hellebore poison, reduces the death rate; If use again it after veratrum poisoning, invalid; The alone Radix Isatidis powder of difference or coptis powder, effect is also bad.< < book on Chinese herbal medicine is stated > >: hardship, and cold, nontoxic.< < book on Chinese herbal medicine is just read > >: enter liver, stomach blood system.The herbal > > of < < China: return liver; Stomach warp.There is heat-clearing, removing toxic substances, cool blood, relieve sore throat effect.Treatment febrile virulent maculae; High heat headache; Major part pestilence; Tongue is dark reddish purple dark, scarlet fever; Erysipelas; Mumps; Larynx numbness; Sore is swollen, carbuncle is swollen; Varicella; Measles; Hepatitis; Influenza, epidemic meningitis, encephalitis, pneumonia, coma is told nosebleed, and pharynx is swollen, pinkeye, sore rash; Can prevent and treat Japanese Type-B encephalitis, acute, chronic hepatitis, mumps, osteomyelitis.
Ligusticum wallichii: ligustrazine energy coronary artery dilator, increase coronary blood flow, improve myocardium blood oxygen supply, and reduce myocardium oxygen demand; The expansible cerebrovascular of ligustrazine, reduces vascular resistence, significantly increases brain and LBF amount, improves microcirculation; Can reduce surface activity of blood platelet, suppress platelet aggregation, the formation of pre-preventing thrombosis; The low dose of promotion of neutral compound of contained forulic acid, heavy dose of uterine smooth muscle that suppresses; Water decoction has sedation to animal central nervous system, and has obvious and lasting hypotensive effect; Can accelerate the to fracture absorption of local hematoma, promotes poroma to form; There is the effect of antivitamin E shortage; Can suppress multiple bacillus; There are antihistaminicum and choleretic effect.
Meropodium pearl: expelling wind and activating blood flow, blood stasis removing analgesic, anti-inflammatory.Cure mainly treating rheumatic ostealgia, traumatic injury, nephroptosis, ephritis etc.
Boston ivy: sweet, puckery, temperature.Function cures mainly: dispelling wind and removing obstruction in the meridians, promoting blood circulation and detoxication.For rheumatic arthritis; Traumatic injury is controlled in external application, carbuncle furuncle poison.
Orange peel: warm in nature, sweet-bitter flavor is nontoxic.Enter spleen, lung two warps.Function cures mainly: regulate the flow of vital energy, reduce phlegm, invigorating the spleen, leads stagnant.The cough that cures cold, poor appetite, chest and abdomen swelling and pain, borborygmus are just rushed down, acute mastitis.
Bodhi is fragrant: pungent, sweet, flat.Function cures mainly: enriching yin and nourishing kidney, flat liver improving eyesight, swelling and pain relieving.Cure cold, dizziness headache, hypertension, anaemia, chronic enterogastritis, irregular menstruation, mastitis, the diseases such as sore.
Radix Glycyrrhizae: property is flat, and taste is sweet, returns 12 warps.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, the anxious pain of four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolysis be so that the pharmacological action such as anticancer, Radix Glycyrrhizae has reducing blood lipid, oxidation resistant effect.
Wilsonii: pungent, the micro-hardship of taste, slightly warm in nature.Return spleen, kidney, the heart channel of Hang-Shaoyin.Modern medicine studies have shown that effect feature and the ginseng of wilsonii is basic identical, has the body of adjusting disorderly, makes it to be tending towards normal function.There is good antifatigue effect, remarkable compared with ginseng, and can significantly improve hypoxia-bearing capability.Bowl spares, benefit essence, strong will, wines used as antirheumatic, strengthen the bone, the function such as blood circulation and promoting silt, stomach invigorating diuresis.Take for a long time " make light of one's life by commiting suicide and endure hardships ".Wilsonii contains noticeable composition---eleutheroside, and it can stimulate mind & body vigor.Numerous scientific publications about wilsonii have proved its antifatigue effect, strengthen endurance and ability, increase alertness and learning ability.Numerous usages have all obtained confirmation in human experimentation.Wilsonii is rehabilitation after being ill, bears too much pressure or anxiety, works excessive, and chronic disease causes weakly crowd and those need to reach very welcome self-medication medicine in the people on physiology and psychological performance peak.At present there is equally the report of considerable quantity to point out that it has support immune system, recover improper low blood pressure, improve the circulatory system, make disorderly glycolipid metabolism normalization, liver, testis, the anabolic effect of bone density and other vitals.Siberian Ginseng P.E shows can irritation cell immunity.Research finds that it can stimulate T-cell to produce, particularly assistant's cell.Therefore wilsonii is used to panimmunity relevant disease.Radix Et Caulis Acanthopanacis Senticosi polysaccharide also has strong inhibitory action to the in-vitro multiplication of mouse S180, human leukaemia K562 cell, and siberian Ginseng P.E is containing multiple glucoside and Radix Et Caulis Acanthopanacis Senticosi polysaccharide, have improve immunity of organisms, increasing leukocyte, raising body to anoxic, radiation, stress, the adaptive capacity of the non-specific injury such as tired, poisoning.Tumour is had to obvious inhibitory action, also can promote marrow hemopoietic stem cells to the differentiation of grain-monocyte, leucocyte to be increased simultaneously.
Akebi: bitter, be slightly cold.Enter the heart channel of Hang-Shaoyin, small intestinl channel, urinary bladder channel.There is clearing away the heart-fire, diuresis, the effect of the lactogenesis of stimulating the menstrual flow.For irritable feverish sensation in chest, larynx numbness pharyngalgia, urinates redly, and five drench, oedema, whole body contraction pain is few through closing breast.Heat is drenched puckery pain, oedema.This product energy inducing diuresis for removing edema, lower dampness removing heat, makes that damp and hot heresy is descending discharges from urine.Treatment bladder damp-heat, scanty drak urine, drenches the puckery pain of drop, the adapteds such as normal and plantain seed, talcum; For oedema, be equipped with umbellate pore furgus, the root bark of white mulberry is equal to use.Aphthae, vexed urine is red.The fire of this product energy supernatant the heart channel of Hang-Shaoyin, under let out small intestine heat.Often control flaring up of heart fire, aphthae, or intestines and the disease such as the vexed urine that causes is red under heart-fire moving downward, the adapteds such as many and radix rehmanniae recen, Radix Glycyrrhizae, the leaf of bamboo.Few through closing breast.These product lactogenesis of stimulating the menstrual flow.With controlling blood stasis through closing, join safflower, peach kernel, the red sage root and be equal to use; If deficient or obstructed with controlling milk, can be equal to use with the seed of cowherb, pangolin; These product can also sharp blood vessels, get round by bribery, and join ramulus mori, coix seed is equal to use, treatment damp-heat arthralgia pain.
Rhizoma cyperi: pungent micro-hardship is sweet, flat, enter liver, tri-jiao channel.The distending pain in hypochondrium; Spargosis is educated; Hernia pain; Irregular menstruation; The full pain of gastral cavity abdomen ruffian; Belch acid regurgitation, the evil of vomitting; Dysmenorrhea; Under uterine bleeding band; Fetal irritability.
Donkey-hide gelatin: sweet, flat.Return lung, liver, kidney channel.Function cures mainly: the enriching yin of enriching blood, moisturize hemostasis.Sallow for the deficiency of blood, dizzy palpitaition, flesh impotence is unable, dysphoria and insomnia, endogenous deficient wind, xeropulmonary cough, the labor spitting of blood of coughing, haematemesis hematuria, the uterine bleeding of having blood in stool, vaginal bleeding during pregnancy.
Cactus: hardship, cool.Function cures mainly: clearing heat and detoxicating, and eliminating stasis to subdue swelling, benefiting stomach and stopping pain, antibechic.For Stomach duodenum ulcer, acute dysentery, cough; Mumps is controlled in external application, mastitis, carbuncle furuncle poison, snake bite, burn and scald.
Crape myrtle: micro-hardship, puckery, flat.Function cures mainly: invigorates blood circulation, and hemostasis, removing toxic substances, detumescence.For various hemorrhage, fracture, mastitis, eczema, hepatitis, cirrhotic ascites.
Dried orange peel: warm in nature, taste is pungent, bitter; Return spleen, lung channel, for diseases such as fullness and oppression of chest and abdomen.The pungent loose logical temperature of orange peel, fragrant odour, is longer than and regulates the flow of vital energy, can enter spleen lung, thus can go loose sluggishness of lung-QI, again can promoting the circulation of qi wide in, for lung qi, gather around the diseases such as the full and taste stagnation of the circulation of vital energy of stagnant, chest diaphragm ruffian, abdominal fullness and distention, for damp retention in middle-jiao, gastral cavity abdomen ruffian is swollen, have loose bowels in loose stool, and the phlegm disease such as cough more.Orange peel dispelling dampness with bitter and warm-natured drugs and can invigorating the spleen promoting the circulation of qi, therefore be usually used in the diseases such as damp retention in middle-jiao, gastral cavity abdominal distension is vexed, loose stool tongue is greasy, can compatibility rhizoma atractylodis, the bark of official magnolia is with using.Be good at again eliminating dampness and eliminating phlegmly, for controlling wet phlegm, stop up the conventional key medicines of lung, the many coughs of phlegm, for insufficiency of the spleen diet reduce, indigestion, and the disease such as n and V.This product eliminating dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and the stomach, diet minimizing, indigestion, stool diarrhea, the fit applications such as normal and ginseng, the bighead atractylodes rhizome, Poria cocos.Can invigorating the spleen because of it, can regulate the flow of vital energy again, therefore often make as the assistant of Qi-tonifying drug, can make tonify without causing stagnation, prevent from stopping up and hold back the swollen effect of doing, in addition, orange peel again can with in, can control stomach Qi rising, n and V.
Gorgon fruit: taste is sweet, puckery, property is flat.Cure mainly rheumatic arthritis, back goinyalgia.Tonifying middle-Jiao and Qi, the strong will of refreshing oneself, makes people's normal hearing and eyesight.It is not hungry that clothes of a specified duration are made light of one's life by commiting suicide people.Can also whet the appetite and help gas and kidney tonifying, control frequency of micturition, seminal emission, purulent leukorrhea.Make powder edible, beneficial people.But children's should not eat more, not beneficial taste, are difficult to digestion.
The membrane of a chicken's gizzard: sweet, cold, return spleen, stomach, small intestine, urinary bladder channel, for food digesting stomach fortifying, arresting seminal emission.The membrane of a chicken's gizzard is containing gastric hormone, keratin, amino acid and micro-pepsin, amylase etc.After oral the membrane of a chicken's gizzard powder, the secretory volume of gastric juice, acidity and eupepsy all increase, and stomach motion is strengthened, emptying quickening.Its acid extractants liquid or decoction can accelerate to get rid of radiostrontium from urine.
Divine Comedy: book on Chinese herbal medicine > > records according to < < the southern regions of the Yunnan Province, and Divine Comedy can " hold up taste to enter diet, the food disappearing in stomach is stopped in place ".Divine Comedy is containing volume saccharomycete, and B family vitamin, also contains multiple B family vitamin, therefore Divine Comedy has the effect of B family vitamin sample in cerevisin.As improve a poor appetite, maintain normal stool function etc.
Hawthorn: cut into slices and dry, put in pot and use force large burnt brown, the inner yellowish-brown of frying to outside for spending, spraying clear water, taking-up is dried, and is charred FRUCTUS CRATAEGI.There is appetite-stimulating indigestion-relieving, change the effect of stagnant long-pending, the promoting blood circulation to remove blood stasis of disappearing, the promoting the circulation of qi of reducing phlegm, meridian distribution of property and flavor, sour, sweet, slightly warm in nature.Main component is containing chlorogenic acid, caffeic acid, crataegolic acid, neat chrysanthemum tartaric acid, Quercetin, ursolic acid, oleanolic acid, hyperin, epicatechin etc.Oral hawthorn can increase digestive ferment, promotes fatty decomposition and digestion, to because of eat meat or greasy too much due to abdominal fullness and distention, belch, do not feel like eating, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines tests shows, hawthorn has the slow and lasting effect reducing blood pressure, and also can reduce cholesterol and triglycerides, atherosclerosis, but also can diastole coronary artery, increase myocardial contractive power, to anti-arrhythmia.Therefore, be conducive to prevent and treat hypertension, high fat of blood, artery sclerosis and coronary heart disease.
Chinese medicine additive of the present invention also comprises: ant, radix bupleuri, glossy ganoderma and rhodiola root.
Ant: taste is salty; Acid; Property is put down.Return liver; Kidney channel.Function cures mainly: tonifying kidney and benefiting sperm; Clearing and activating the channels and collaterals; Removing toxicity for detumescence.The main dizzy tinnitus of suffering from a deficiency of the kidney; Insomnia and dreamful sleep; Impotence and seminal emission; Arthralgia due to wind-dampness; Hemiplegia 6; Numb in every limb; Erythematosus lupus; Chorionitis; Dermatomyositis; The carbuncle furunculosis that swells; Venomous snake bite.
Radix bupleuri: clearind deficient heat Chinese medicine, for cold, fever, fevers and chills alternate, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, uterus come off, irregular menstruation.Radix bupleuri begins to be loaded in < < Sheng Nong's herbal classic > >, classifies as top grade.Promote immunity function, active ingredient: Bupleurum chinense polysaccharide.Effect: phagocytic function strengthens, Natural killer activity strengthens, and improves special viral antibody titre, improves lymphocyte and turns core rate, improves skin delayed hypersensitivity reaction.Anti-liver injury, Bupleurum injection (concentration 1: a 1) 1 ml/ hypodermic injection can significantly reduce the rat blood serum GPT rising that carbon tetrachloride causes for continuous 5 days, degeneration of liver cells and necrosis also obviously alleviate, and in liver cell, glycogen and rna content also approach normal.
Glossy ganoderma: property is sweet, flat.The thoughts of returning home, lung, liver, kidney channel.Cure mainly consumptive disease, cough, asthma, insomnia, indigestion, malignant tumour etc.Animal pharmacology shows experiment: glossy ganoderma has inhibitory action to nervous system, and the circulatory system has step-down and strengthens the effect of cardiac contractile force, and respiratory system is had to phlegm-dispelling functions, in addition, protects in addition liver, improves immunologic function, antibacterially waits effect.
Rhodiola root: sweet, puckery, cold.Function cures mainly: removing heat from the lung to relieve cough, hemostasis, only band.For cough with lung heat, spitting of blood, leukorrhea; Traumatic injury is controlled in external application, burn and scald.Tonifying Qi clearing lung-heat; Intelligence development is nourished heart; Controlling of bleeding with astringents; Eliminating stasis to subdue swelling.Main deficiency of vital energy and physically weak; Chilly after being ill; Shortness of breath and fatigue; Cough with lung heat; Spitting of blood; Leukorrhea diarrhoea; Traumatic injury; Burn and scald; Neurosis; Altitude sickness.
Embodiment 1 feed 1
The embodiment of the present invention 1 provides a kind of feed that is used for the treatment of mastitis for milk cows, and feed is comprised of the raw material of following parts by weight: barley 65 weight portions, oat 55 weight portions, soybean 35 weight portions, peanut meal 25 weight portions, clover dry powder 25 weight portions, pomelo peel 15 weight portions, golden mushroom slag 15 weight portions, Kelp Powder 15 weight portions and Chinese medicine additive 15 weight portions.
Wherein, Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portions, Radix Codonopsis 15 weight portions, finelydivided phtheirospermum root 13 weight portions, Radix Angelicae Sinensis 15 weight portions, bitter leaves 20 weight portions, notopterygium root 17 weight portions, Radix Isatidis 13 weight portions, Ligusticum wallichii 17 weight portions, meropodium pearl 13 weight portions, Boston ivy 13 weight portions, orange peel 15 weight portions, fragrant 17 amounts part of bodhi, Radix Glycyrrhizae 16 weight portions, wilsonii 15 weight portions, akebi 12 weight portions, rhizoma cyperi 13 weight portions, donkey-hide gelatin 12 weight portions, cactus 13 weight portions, crape myrtle 15 weight portions, dried orange peel 14 weight portions, Gorgon fruit 13 weight portions, the membrane of a chicken's gizzard 13 weight portions, Divine Comedy 18 weight portions and hawthorn 13 weight portions.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, mixes all raw medicinal materials in proportion, is ground into 100 object powder, adds the water with respect to 5 times of mixture qualities, at the temperature of 90 ℃, decocts 30 minutes, and decoction liquor is filtered, and obtains the first filtered fluid and filter residue;
Second step, the filter residue that the first step is obtained adds the water with respect to 3 times of first step mixture qualities, at the temperature of 90 ℃, decocts 1 hour, and decoction liquor is filtered, and obtains the second filtered fluid;
The 3rd step, merges the first filtered fluid and the second filtered fluid, and reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, guarantees that EAT is at 190 ℃, and 80 ℃ of leaving air temps, are ground into 200 orders subsequently, obtain Chinese medicine additive powder.
Embodiment 2 Chinese medicine additives 2
The embodiment of the present invention provides a kind of feed that is used for the treatment of mastitis for milk cows, and feed is comprised of the raw material of following parts by weight: barley 62 weight portions, oat 49 weight portions, soybean 39 weight portions, peanut meal 24 weight portions, clover dry powder 24 weight portions, pomelo peel 13 weight portions, golden mushroom slag 12 weight portions, Kelp Powder 13 weight portions and Chinese medicine additive 13 weight portions.
Wherein, Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portions, Radix Codonopsis 15 weight portions, finelydivided phtheirospermum root 13 weight portions, Radix Angelicae Sinensis 15 weight portions, bitter leaves 20 weight portions, notopterygium root 17 weight portions, Radix Isatidis 13 weight portions, Ligusticum wallichii 17 weight portions, meropodium pearl 13 weight portions, Boston ivy 13 weight portions, orange peel 15 weight portions, fragrant 17 amounts part of bodhi, Radix Glycyrrhizae 16 weight portions, wilsonii 15 weight portions, akebi 12 weight portions, rhizoma cyperi 13 weight portions, donkey-hide gelatin 12 weight portions, cactus 13 weight portions, crape myrtle 15 weight portions, dried orange peel 14 weight portions, Gorgon fruit 13 weight portions, the membrane of a chicken's gizzard 13 weight portions, Divine Comedy 18 weight portions, hawthorn 13 weight portions, ant 13 weight portions, radix bupleuri 17 weight portions, glossy ganoderma 12 weight portions and rhodiola root 13 weight portions.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, mixes all raw medicinal materials in proportion, is ground into 150 object powder, adds the water with respect to 4 times of mixture qualities, at the temperature of 95 ℃, decocts 45 minutes, and decoction liquor is filtered, and obtains the first filtered fluid and filter residue;
Second step, the filter residue that the first step is obtained adds the water with respect to 2 times of first step mixture qualities, at the temperature of 95 ℃, decocts 45 minutes, and decoction liquor is filtered, and obtains the second filtered fluid;
The 3rd step, merges the first filtered fluid and the second filtered fluid, and reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, guarantees that EAT is at 180 ℃, and 70 ℃ of leaving air temps, are ground into 300 orders subsequently, obtain Chinese medicine additive powder.
Embodiment 3 paste
The embodiment of the present invention provides a kind of medicine that is used for the treatment of mastitis for milk cows, raw medicinal material by following parts by weight forms: the Radix Astragali 23 weight portions, Radix Codonopsis 15 weight portions, finelydivided phtheirospermum root 13 weight portions, Radix Angelicae Sinensis 15 weight portions, bitter leaves 20 weight portions, notopterygium root 17 weight portions, Radix Isatidis 13 weight portions, Ligusticum wallichii 17 weight portions, meropodium pearl 13 weight portions, Boston ivy 13 weight portions, orange peel 15 weight portions, fragrant 17 amounts part of bodhi, Radix Glycyrrhizae 16 weight portions, wilsonii 15 weight portions, akebi 12 weight portions, rhizoma cyperi 13 weight portions, donkey-hide gelatin 12 weight portions, cactus 13 weight portions, crape myrtle 15 weight portions, dried orange peel 14 weight portions, Gorgon fruit 13 weight portions, the membrane of a chicken's gizzard 13 weight portions, Divine Comedy 18 weight portions, hawthorn 13 weight portions, ant 13 weight portions, radix bupleuri 17 weight portions, glossy ganoderma 12 weight portions and rhodiola root 13 weight portions.
The embodiment of the present invention also provides a kind of preparation method who is used for the treatment of the medicine of mastitis for milk cows, and medicine is paste, and preparation method comprises the following steps:
Take by weight all raw medicinal materials and soak 1.5 hours, be then placed in multi-function extractor, decoct for the first time amount of water and be 7 times of medicinal material, decoct, while being heated to 100 ℃, start timing, micro-boiling after 2 hours, filters and emits liquid from feed opening, puts in fluid reservoir; Decoct for the second time, amount of water is 7 times of amounts of medicinal material, is heated to 100 ℃, and micro-boiling after 2 hours extracted liquid out, merges with the liquid decocting for the first time; By merging in the decoction liquor suction reduced pressure concentration tank of latter 2 times, be decompressed to 0.05MPa, temperature remains on 70 ℃, and being concentrated into relative density is 1.20, and the medicinal extract of temperature to 65 ℃ is cooling; The pearl powder of getting medicinal extract weight 10% adds in medicinal extract, stirs, tinning after ultraviolet irradiation-sterilize sterilization.
Toxicity test
1, cumulative toxicity test report
Select 20 healthy mices, female, male each 10, the Chinese medicine additive of the embodiment of the present invention 1 of take is object, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.The Chinese medicine additive of embodiment 2 of take is object, carries out according to the method described above toxicity test, and result is as identical in embodiment 1.
2, acute toxicity test
40 of application NIH mouse, SPF level, male and female half and half, body weight 16～20g, carries out acute toxicity test.Mouse is divided into two groups at random, and 20 every group, control group and administration group, test front fasting 12 hours; The Chinese medicine additive of embodiments of the invention 1 preparation is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), control group gives equivalent physiological saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and records toxic reaction and the death toll of mouse.Experimental result shows: with control group comparison, after administration, mouse has no notable difference, experiment Continuous Observation 14 days, and mouse overall health of patients, diet, drinking-water, body weight gain are all normal.The powder 1LD50>32.9 crude drug/kg of the mouse oral administration gavage embodiment of the present invention 1, every day, maximum dosage-feeding was 65.8g crude drug/kg/ day.The clinical application amount of the Chinese medicine additive of the embodiment of the present invention 1 is 3g crude drug/day/head, and piglet body weight is in 6kg, and average dosage is 0.5g crude drug/kg/ day.By batheroom scale: the dosis tolerata of the Chinese medicine additive of mouse (average weight take 20g) the oral administration gavage embodiment of the present invention 1 is quantity 131 times.Therefore the acute toxicity of the Chinese medicine additive of the embodiment of the present invention 1 is low, clinical drug safety.The Chinese medicine additive of embodiment 2 of take is object, carries out according to the method described above toxicity test, and result is as identical in embodiment 1.
3, external application acute skin irritation test
These product are according to 6.3 joints in the < < of Ministry of Public Health cosmetics health standard > > (2002) second portion " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg～3kg, the paste of getting the 0.5g embodiment of the present invention 3 directly spreads upon on the skin of animal left side (opposite side in contrast), adopt blocking test, 4 hours application time, after off-test, use the residual tested material of warm water washing, 1h after removing tested material, 24h, 48h and 72h observe respectively the dermoreaction of the tested district of animal and check plot, top average is " 0 ", judge that these product are to animal skin nonirritant.
4, external application acute dermal toxicity test
These product are according to the < < of Ministry of Public Health cosmetics health standard > > (2002) second portion " acute dermal toxicity test " test method(s) of once limiting the quantity of, 20 of SD rats, male and female half and half, body weight 90g～180g, by the paste of the embodiment of the present invention 3, once through skin, smear 5000mg/kg body weight dosage, observe 15 days, do not find obvious poisoning symptom, nothing death, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.
Clinical testing
(1) animal used as test
160 milk cows that suffer from after diagnosing mammitis that animal used as test provides for certain cattle farm.Tested on May 21,6 days to 2012 May in 2012, duration of test carries out daily feeding and management by cattle farm Routine Management way.
(2) test method
160 ill milk cows are divided into four experimental group at random, every group 40, four experimental group are used respectively the feed (embodiment group 1) of the embodiment of the present invention 1, feed (embodiment group 2), the feed of embodiment 2 and the paste of embodiment 3 of embodiment 2 are used (embodiment group 3) and conventional medicament (control group) to treat jointly.In embodiment group 3, paste coordinates the feed of embodiment 2 to use, and every day smeared twice by paste, uses continuously 8-15 days.
(3) criterion of therapeutical effect
Clinical testing of the present invention adopts California mammitis detection method (CMT) determination methods to provide curative effect determinate standard, and as shown in table 1, wherein efficient is the summation of " recovery from illness " and " improvement "; California mammitis detection method (CMT) determination methods and standard are as shown in table 2.
Table 1 clinical testing curative effect determinate standard of the present invention
Table 2 California mammitis detection method (CMT) determination methods and standard
(4) result for the treatment of
Result is as shown in table 1, and from result for the treatment of, adopting feed of the present invention is more than 90% to the treated effect of mastitis for milk cows.
From the data of table 1, compare with control group, use the feed treatment mastitis for milk cows of the embodiment of the present invention 1 and embodiment 2 have advantages of evident in efficacy, cure rate is high, externally used paste of the present invention and feed the two to be used in conjunction with effect especially obvious; In long-term observation subsequently, find, the milk cow of embodiment group 1, embodiment group 2 and 3 recoveries from illness of the embodiment group again incidence of disease is starkly lower than the milk cow of control group.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the feed that is used for the treatment of mastitis for milk cows, is characterized in that, described feed comprises following raw material: barley, oat, soybean, peanut meal, clover dry powder, pomelo peel, golden mushroom slag, Kelp Powder and Chinese medicine additive.
2. the feed that is used for the treatment of mastitis for milk cows according to claim 1, it is characterized in that, described feed is comprised of the raw material of following parts by weight: barley 50-70 weight portion, oat 40-60 weight portion, soybean 30-50 weight portion, peanut meal 20-30 weight portion, clover dry powder 20-30 weight portion, pomelo peel 10-15 weight portion, golden mushroom slag 10-15 weight portion, Kelp Powder 10-15 weight portion and Chinese medicine additive 5-17 weight portion.
3. the feed that is used for the treatment of mastitis for milk cows according to claim 1 and 2, it is characterized in that, described feed is comprised of the raw material of following parts by weight: barley 55-65 weight portion, oat 45-55 weight portion, soybean 35-45 weight portion, peanut meal 23-25 weight portion, clover dry powder 22-25 weight portion, pomelo peel 10-15 weight portion, golden mushroom slag 10-15 weight portion, Kelp Powder 10-15 weight portion and Chinese medicine additive 9-17 weight portion.
4. according to the feed that is used for the treatment of mastitis for milk cows described in claim 1-3 any one, it is characterized in that, described Chinese medicine additive comprises following raw medicinal material: the Radix Astragali, Radix Codonopsis, finelydivided phtheirospermum root, Radix Angelicae Sinensis, bitter leaves, notopterygium root, Radix Isatidis, Ligusticum wallichii, meropodium pearl, Boston ivy, orange peel, bodhi perfume, Radix Glycyrrhizae, wilsonii, akebi, rhizoma cyperi, donkey-hide gelatin, cactus, crape myrtle, dried orange peel, Gorgon fruit, the membrane of a chicken's gizzard, Divine Comedy and hawthorn.
5. according to the feed that is used for the treatment of mastitis for milk cows described in claim 1-4 any one, it is characterized in that, described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, finelydivided phtheirospermum root 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, bitter leaves 15-25 weight portion, notopterygium root 10-25 weight portion, Radix Isatidis 10-16 weight portion, Ligusticum wallichii 13-20 weight portion, meropodium pearl 10-15 weight portion, Boston ivy 10-15 weight portion, orange peel 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, wilsonii 10-20 weight portion, akebi 10-15 weight portion, rhizoma cyperi 10-15 weight portion, donkey-hide gelatin 10-15 weight portion, cactus 10-15 weight portion, crape myrtle 10-20 weight portion, dried orange peel 10-20 weight portion, Gorgon fruit 10-15 weight portion, the membrane of a chicken's gizzard 10-15 weight portion, Divine Comedy 15-20 weight portion and hawthorn 10-15 weight portion.
6. according to the feed that is used for the treatment of mastitis for milk cows described in claim 1-5 any one, it is characterized in that, described Chinese medicine additive also comprises: ant, radix bupleuri, glossy ganoderma and rhodiola root.
7. according to the feed that is used for the treatment of mastitis for milk cows described in claim 1-6 any one, it is characterized in that, described feed is comprised of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, finelydivided phtheirospermum root 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, bitter leaves 15-25 weight portion, notopterygium root 10-25 weight portion, Radix Isatidis 10-16 weight portion, Ligusticum wallichii 13-20 weight portion, meropodium pearl 10-15 weight portion, Boston ivy 10-15 weight portion, orange peel 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, wilsonii 10-20 weight portion, akebi 10-15 weight portion, rhizoma cyperi 10-15 weight portion, donkey-hide gelatin 10-15 weight portion, cactus 10-15 weight portion, crape myrtle 10-20 weight portion, dried orange peel 10-20 weight portion, Gorgon fruit 10-15 weight portion, the membrane of a chicken's gizzard 10-15 weight portion, Divine Comedy 15-20 weight portion, hawthorn 10-15 weight portion, ant 10-16 weight portion, radix bupleuri 15-20 weight portion, glossy ganoderma 10-15 weight portion and rhodiola root 10-15 weight portion.
8. according to the feed that is used for the treatment of mastitis for milk cows described in claim 1-7 any one, it is characterized in that, described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, finelydivided phtheirospermum root 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, bitter leaves 18-22 weight portion, notopterygium root 15-20 weight portion, Radix Isatidis 12-14 weight portion, Ligusticum wallichii 15-18 weight portion, meropodium pearl 12-14 weight portion, Boston ivy 12-14 weight portion, orange peel 13-18 weight portion, the fragrant 16-18 amount part of bodhi, Radix Glycyrrhizae 15-18 weight portion, wilsonii 13-18 weight portion, akebi 11-14 weight portion, rhizoma cyperi 12-14 weight portion, donkey-hide gelatin 11-14 weight portion, cactus 11-14 weight portion, crape myrtle 12-18 weight portion, dried orange peel 12-17 weight portion, Gorgon fruit 11-14 weight portion, the membrane of a chicken's gizzard 11-14 weight portion, Divine Comedy 17-19 weight portion, hawthorn 12-14 weight portion, ant 12-14 weight portion, radix bupleuri 16-19 weight portion, glossy ganoderma 11-13 weight portion and rhodiola root 11-14 weight portion.
9. according to the feed that is used for the treatment of mastitis for milk cows described in claim 1-8 any one, it is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
The first step, mixes all raw medicinal materials in proportion, is ground into 100 order～200 object powder, add the water with respect to 3～5 times of mixture qualities, at the temperature of 90 ℃～100 ℃, decoct 30 minutes～1 hour, decoction liquor is filtered, and obtains the first filtered fluid and filter residue;
Second step, the filter residue that the first step is obtained adds the water with respect to 1～3 times of first step mixture quality, at the temperature of 90 ℃～100 ℃, decocts 30 minutes～1 hour, and decoction liquor is filtered, and obtains the second filtered fluid;
The 3rd step, merges the first filtered fluid and the second filtered fluid, and reduced pressure concentration is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer dry, guarantee that EAT is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, are ground into 200 order～400 orders subsequently, obtain Chinese medicine additive powder.
10. a preparation method for the feed that is used for the treatment of mastitis for milk cows as described in claim 1-9 any one, is characterized in that, described preparation method comprises the following steps:
(1) broken step: take by weight corn, wheat, millet, oat, alfalfa meal and honey skin of beancurd, drop into pulverizer and carry out Crushing of Ultrafine, cross 2.0mm sieve after pulverizing;
(2) batching step: take salt, vitamin D and Chinese medicine additive according to parts by weight, pulverize the fine powder obtaining mix with step (1), drop into mixer, mix, incorporation time is 30-60s;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 85 ℃, and its gelatinization degree is reached more than 90%.
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| CN104855735A (en) * | 2015-06-11 | 2015-08-26 | 山东新希望六和集团有限公司 | Feed used for cows postpartum and preparation method thereof |
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| CN105707463A (en) * | 2016-04-28 | 2016-06-29 | 青岛海之星生物科技有限公司 | Enteromorpha feed for dairy cattle and preparation method thereof |
| CN105998618A (en) * | 2016-06-29 | 2016-10-12 | 河北省畜牧兽医研究所 | Method for preparing traditional Chinese medicine preparation for improving dairy cow immunity and preventing dairy cow mastitis |
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| CN106879828A (en) * | 2017-03-27 | 2017-06-23 | 上海华扩达生化科技有限公司 | A kind of feed formula and processing method for improving animal immune performance |
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