CN105998618A - Method for preparing traditional Chinese medicine preparation for improving dairy cow immunity and preventing dairy cow mastitis - Google Patents

Abstract

The invention provides a method for preparing a traditional Chinese medicine preparation for improving dairy cow immunity and preventing dairy cow mastitis, and belongs to the technical field of traditional Chinese medicine preparations. The method comprises the following steps: respectively processing radix rehmanniae preparata, haws, semen raphani, rheum officinale and pig nails, then mixing the processed materials with astragalus membranaceus, codonopsis pilosula, angelica sinensis, rhizoma atractylodis macrocephalae, pericarpium citri reticulatae, licorice root, ligusticum wallichii, cistanche salsa, radix ophiopogonis, radix paeoniae alba, cacumen biotae, cape jasmine and capillary artemisia, and grinding to obtain ground material; then, adding the ground material into corn flour, glucose and water, and uniformly mixing; adding zymophyte, performing aerobic fermentation for 48-72 hours, and performing anaerobic fermentation for more than 1 week; drying in a shadow place, and adding a carrier to obtain the traditional Chinese medicine preparation for improving dairy cow immunity and preventing dairy cow mastitis. The traditional Chinese medicine preparation can be used for improving body immunity and effectively reducing the incidence rate of subclinical mastitis and clinical mastitis of dairy cows, so that health and high output of dairy cow can be realized and the healthy level of dairy cow can be improved.

Description

Improve the preparation method of the Chinese medicine preparation of milch cow immunity, prevention mammitis of cow

Technical field

The invention belongs to the technical field of Chinese medicine preparation, relate to a kind of raising milch cow immunity, prevention milk The preparation method of the Chinese medicine preparation of Mammitis of cattle, is specifically related to improve milch cow immunity, prevention milk Lac Bovis seu Bubali The preparation method of the Chinese medicine preparation that room is scorching.Chinese medicine preparation of the present invention based on spleen, stomach, with soothing liver and strengthening spleen, Based on vital base and primordial QI consolidating, regulation taste are received and transportation capabilities have effect greatly to body health.Logical Cross Chinese medicine and contain multiple natural nutrient component and various bioactivators, body saccharide generation can be promoted Thank, protein synthesis, again can enhancing immunity, improve production performance.

Background technology

Chinese herbal feed additive applies that China tradition Chinese veterinarian is theoretical, the physical property of Chinese herbal medicine (negative and positive, Cold and cool, warm), relation between thing taste (sour, bitter, sweet, pungent, salty) and thing, animal is played health care, Increase feed intake, promote absorption of nutrient ingredients, raising production performance and reduce the effect of food consumption. At present, animal food is increasingly paid attention to by drug contamination and the impact on human health.Along with The understanding of the common drug toxic and side effects such as antimicrobial drug and hormone is constantly deepened by people, and people are to food The extensive concern of product safety, Chinese herbal feed additive is unrivaled because having normal diet additive Advantage and by the common concern of domestic and international feedstuff industry.And the Chinese herbal feed for cow in milk adds Agent product is commercially little, and its commercial application in cow in milk produces reality also rarely has report.

The test such as Sun Fengjun shows, using Chinese herbal medicine additive feeding cow, test group every averagely increases day by day Anharmonic ratio matched group improves 20.93%, increases milk yield 4.5kg/ (head d)；Fan Zhenhua etc. are in cow in milk day Adding Chinese herbal medicine additive in grain, the feeding experiment through 60d makes milch cow daily yielding averagely improve 4.3kg, butterfat percnetage improves 0.171 percentage point；Fiber crops peak, the court of a feudal ruler etc. adds certain in the daily ration of milch cow The Chinese herbal medicine additive of amount, can significantly improve milk production of cow, and effectively reduce mammitis of cow Sickness rate.But these researchs are most under test, and mechanism of action is the clearest and the most definite；And current city Sell preparation and often have that processing technology is backward, addition is bigger than normal, palatability is poor, using effect is unstable Etc. problem, become the bottleneck restricting its industrialization.

Summary of the invention

The present invention solves that processing technology is backward, addition is bigger than normal present in prior art, agreeable to the taste Property poor, the problem such as using effect is unstable, it is provided that a kind of improve milch cow immunity, prevention cow breast The preparation method of scorching Chinese medicine preparation.

The present invention the technical scheme is that for realizing its purpose

The preparation method of a kind of Chinese medicine preparation improving milch cow immunity, prevention mammitis of cow, by ripe Ground, Fructus Crataegi, Semen Raphani, Radix Et Rhizoma Rhei, Unguis Sus domestica are concocted respectively, these things after then concocting Material with the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Rhizoma Chuanxiong, Herba Cistanches, Radix Ophiopogonis, the Radix Paeoniae Alba, Pulverize after Cacumen Platycladi, Fructus Gardeniae, Herba Artemisiae Scopariae mixing, obtain comminuting matter, then add in comminuting matter Semen Maydis powder, glucose, water mix homogeneously, addition zymocyte, first oxygen consumption fermentation 48-72h, the most again Anaerobic fermentation more than 1 week, dries in the shade, adds carrier, is improved milch cow immunity, prevention cow breast Scorching Chinese medicine preparation.

Each raw material of Chinese medicine is prepared by following parts by weight: Radix Astragali 150-200 part, Radix Codonopsis 40-80 part, when Return 40-80 part, Radix Rehmanniae Preparata 40-80 part, Rhizoma Atractylodis Macrocephalae 30-60 part, Pericarpium Citri Reticulatae 40-80 part, Radix Glycyrrhizae 15-45 part, Rhizoma Chuanxiong 15-45 part, Herba Cistanches 30-50 part, Radix Ophiopogonis 30-50 part, Radix Paeoniae Alba 30-50 part, Fructus Crataegi 60-150 Part, Semen Raphani 40-80 part, Cacumen Platycladi 60-100 part, Radix Et Rhizoma Rhei 5-15 part, Fructus Gardeniae 10-30 part, mattress Old 40-80 part, Unguis Sus domestica 40-80 part.

Radix Rehmanniae Preparata is concocted and is included: be placed in marmite by Radix Rehmanniae Preparata, adds sand, fries under the conditions of 100-150 DEG C 20-40min, sieve removes sand, cools.The process of preparing Chinese medicine to Radix Rehmanniae Preparata, is the problem viscous in order to solve its property, Remove moisture removal so that it is quality becomes fragile, it is possible to smoothly complete disintegrating process.

The process of preparing Chinese medicine of Fructus Crataegi includes: Fructus Crataegi is placed in marmite, and slow fire is fried to burned black, cools.Fructus Crataegi The property of medicine in, life major function is dyspepsia and intestinal stasis relieving, blood circulation promoting and blood stasis dispelling；After parching to brown, add treatment companion Have dysentery effect of food stagnation, and the slight food stagnation of milch cow and the loose and watery stool that thus causes half congealed be produce in Common problem；And fry to surface blackening, adding effect for the treatment of accumulation of blood, this is to lactogenic and breeding System problem (stagnation of QI and blood) has good opsonic action.

The process of preparing Chinese medicine of Semen Raphani includes: Semen Raphani is placed in marmite, fries to Raphanus sativus L under the conditions of 100-150 DEG C Sub-seed surplus color is turned black, and savory spilling cools.Semen Raphani processing action, Semen Raphani (parched) Change the property of medicine, turn and be upgraded to fall；Heaving explosion, qualitative change is crisp, is beneficial to pulverize and fried effective ingredient. It is longer than the de-swelling that helps digestion, lowering the adverse-rising QI to resolve phlegm.The merit that the present invention helps digestion with its sending down the abnormal ascending QI, for improving cud and digestion The Chinese medicine ancillary drug of function, therefore fry and use.

The process of preparing Chinese medicine of Radix Et Rhizoma Rhei includes: by Radix Et Rhizoma Rhei, squirts with 35-45 degree wine, then slow fire fried dry, cools ?.Radix Et Rhizoma Rhei life is exerted oneself violent with rushing down, and cooks to rush down and exerts oneself to relax, and it is burning hot that processed with wine is apt to clear top, and parch to black can Removing stasis to stop bleeding.Radix et Rhizoma Rhei (stir-fried with wine) has purging heat to relax the bowels effect, constipation, abdomen stagnant for Gastrointestinal excess heat Portion's distension, pain with tenderness, even hyperpyrexia, unconsciousness and delirium, such as DACHENGQI TANG；Or spleen YANG deficiency Cold accumulation and constipation, such as wenpi decoction.Radix Et Rhizoma Rhei (processed) fried by present invention wine, mainly with the removing toxic substances of its eliminating carbuncle, blood stasis expelling Stimulate the menstrual flow, effect of removing damp-heat.Equal to Radix Et Rhizoma Rhei anthraquinone analog derivative contained by it after ecliptic longitude steeping in wine parch greatly Having an impact, it rushes down lower composition Sennosides and the obvious decrement of chrysophanic acid, heats tannin impact less, because of This discharge function weakens and astriction strengthens relatively.

The process of preparing Chinese medicine of Unguis Sus domestica includes: first soaking 20-40min with 35-45 degree wine, pull out, it is unnecessary to drain Moisture, puts in frying pan, with fine sand same stir-fry under the conditions of 120-180 DEG C, fries to the most brown and crisp, takes out, and sieve goes Fine sand, soaks 5-7min with vinegar while hot, then pulls out, dry.The purpose that Unguis Sus domestica is concocted has Two aspects, one is by processing stir-fry generation effect expanded, brittle, it is easy to grinding and processing；After two are the process of preparing Chinese medicine Each utilization rate of active components improves；Three is to be concocted by wine and vinegar, enhances stimulating milk secretion of stimulating the menstrual flow, and eliminating carbuncle is arranged Pus, blood circulation promoting and blood stasis dispelling and put a body into a coffin liver yin nourishing, strengthen body immunity effect.Unguis Sus domestica is first used when concocting Ethanol soaks, and it is expanded then to process stir-fry, can strengthen its lactogenesis invigorate blood circulation, blood stasis dispelling evacuation of pus, eliminating carbuncle etc. Effect function.Its high temperature processed with vinegar is taken advantage of so that vinegar performance immerses in fluffy Unguis Sus domestica, and shadow after stir-fry Ring its property of medicine, strengthen its hold back liver yin nourishing (smell of vinegar acid, specially enter Liver Channel, the soothing the liver work that relieves the pain of medicine can be strengthened With, and energy blood circulation promoting and blood stasis dispelling, dispersing the stagnated live-QI to relieve the stagnation of QI), strengthen body immunity effect.The most above-mentioned process of preparing Chinese medicine energy Improve the bioavailability of Unguis Sus domestica.

Comminuting matter, Semen Maydis powder, glucose, the ratio of weight and number of water are 100:(4-6): (0.8-1.2): (28-32)。

Described zymocyte be mass ratio be saccharomyces cerevisiae and the bacillus subtilis of 10:1, described wine The addition of brewer yeast bacterium is the 1-1.2% of comminuting matter.

Described carrier is yeast product, and carrier is (6-8) with the weight ratio of comminuting matter: (2-4), Described yeast product is by the Semen Maydis powder yeast by the soybean meal of 55-65% Yu 35-45% Bacterium by fermentation, dry, and obtains yeast product by product.

The invention has the beneficial effects as follows:

(1) improve immunity of organisms, effectively reduce milk cow recessive mastitis and clinical mastitis morbidity；

(2) improve function of rumen, protect gastrointestinal mucosal, reduce digestive tract disease, improve efficiency of feed utilization；

(3) milch cow limb hoof disease and alcohol positive milk incidence rate are reduced；

(4) anti-hot and cold various stress, reduce production loss；

(5) improve milk yield 5%-15%, improve butterfat percnetage and each 0.1-0.2 percentage point of protein ratio, real Existing milk cow health high yield；

(6) improve blood pH and liver function index of correlation, improve milk cow health level.

The Chinese medicine preparation of the present invention, by the feeding experiment to cow in milk so that healthy interpolation group and disease The average daily per unit area yield of cattle interpolation group is respectively increased 0.80kg and 2.08kg；Latent mammitis cattle gets well, and Protein ratio averagely improves 0.4 percentage point；Butterfat percnetage and the protein ratio of healthy interpolation group carry respectively High 0.42 percentage point and 0.19 percentage point.Significantly improving breast index, strengthening and summer heat is answered In the case of the tolerance swashed, every increases economic benefit 3.2-11.2 unit cattle day.

Radix Rehmanniae Preparata, Fructus Crataegi, Semen Raphani, Radix Et Rhizoma Rhei, Unguis Sus domestica are more conducive to collaborative of whole preparation after concocting Wave righting dispel tiltedly, spleen invigorating nourishing the liver, the effect such as eliminating carbuncle toxin expelling, by improving digestive function, improving body Immunity reaches to prevent bovine subclinical mastitis, reduce somatic effect.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further illustrated.

In the present invention, the mechanism of action of each raw material is as follows:

The Radix Astragali: its have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, fall The clinical efficacy such as pressure；Its property is sweet, tepor, enter, lung, spleen, liver, kidney channel, there is invigorating QI to consolidate the body surface resistance, And big spleen reinforcing sun function, all void can be controlled；We with its consolidating superficial resistance spleen reinforcing, improve immunity and protect the liver anti- Stress thinks principal agent, therefore consumption is big and monarch drug in the side of being.

Radix Codonopsis: Radix Codonopsis has enhancing immunity, expansion blood vessel, blood pressure lowering, improves microcirculation, enhancing hemopoietic Functions etc. act on；Radix Codonopsis sweet in the mouth is put down.Invigorating the spleen and replenishing QI, stomach function regulating is had to promote the production of body fluid, the effect such as expelling phlegm for arresting cough, For weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, the disease such as proctoptosis.This Invention assists the Radix Astragali, QI invigorating stomach function regulating, improves immunity of organisms, be for accessory drugs.

Radix Angelicae Sinensis: have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation, anti-old, raising anticancer, anti-ageing Effect of immunity.Radix Angelicae Sinensis sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, mend In have, row in have benefit, for the key medicine in blood.Thus, it can be enriched blood, and can invigorate blood circulation again, both may be used Stimulate the menstrual flow, again can be active；And the dredge the meridian passage of Radix Angelicae Sinensis is with better function.Side uses Radix Angelicae Sinensis, enriches blood with it Blood circulation-promoting functions is assisted principal agent benefiting vital QI and blood, is improved immunity, again with its dredge the meridian passage function, improves micro- Circulation, strengthens the mammary glandular cell repair ability to damage.

Radix Rehmanniae Preparata: have YIN nourishing effect of enriching blood, can be used for blood deficiency and yellow complexion, dizziness, palpitation and insomnia, menstruation Uncomfortable, the disease such as metrorrhagia, also can be used for deficiency of kidney yin hectic fever hectic fever due to YIN-deficiency, night sweat, pass out semen, the disease such as quench one's thirst, It it is one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.The present invention is by its yin nourishing merit of enriching blood Effect, assists principal agent qi and blood tonifying, improves immunity, strengthens hepatic and renal function.

The Rhizoma Atractylodis Macrocephalae: there is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, for insufficiency of the spleen lack of appetite, Abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Dehumidifying benefit is dry, and middle QI invigorating, temperature In, go in taste wet, except gastric heat, strong taste, enter diet, antiabortive.Meridian distribution of property and flavor bitter in the mouth, sweet, Warm in nature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, Abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive. For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.Our with its invigorating the spleen and benefiting QI dampness stomach strengthening, enhancement Effect of diet, assists Radix Astragali benefiting QI for strengthening the superficies, improves immunity of organisms, is for ministerial drug.

Pericarpium Citri Reticulatae: bitter in the mouth, pungent, warm in nature, return lung, spleen channel, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, regulate the flow of vital energy strong Spleen, drying dampness to eliminate phlegm, for distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.In the present invention, mainly use Its spleen invigorating is regulated the flow of vital energy effect, on the one hand function of spleen and stomach regulating function, whetting appetite, on the other hand, releases QI invigorating The taste of all medicines of enriching blood is greasy, assists its effect of bringing into normal play.

Radix Glycyrrhizae: sweet in the mouth, property are flat, its effect replenishing QI to invigorate the spleen, nourishing the lung to arrest cough, relieving spasm to stop pain, heat clearing away solution Poison, coordinating the actions of various ingredients in a prescription etc.；The present invention mainly with in its replenishing QI to invigorate the spleen, sweet mitigation, solve sore swollen toxin and The characteristic of coordinating the actions of various ingredients in a prescription, is that (, as high yield animal, its taste burden is heavy, often has contraction for milch cow in order to make medicine Pain is uncomfortable, and mammary gland problem belongs to the disease of skin infection).

Rhizoma Chuanxiong: for blood-activating and qi-promoting, wind-expelling pain-stopping.The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keeps, Ji Nenghang Dissipate, up up to top, mountain peak；Enter again blood system, descending up to the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, suitably The various disease of stagnation of blood stasis；Wind-expelling pain-stopping, effectiveness is favourable, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia. It is the gas medicine in blood that former times people calls Rhizoma Chuanxiong, the function such as its residence of dangerous speech is pungent to be dissipated, resolving depression, sensible, pain relieving.This Invention leads all medicines with it, amounts to mammary gland, is for envoy in medicine.

Herba Cistanches: sweet in the mouth；Salty；Warm in nature, return kidney；Large intestine channel, kidney-replenishing；Benefiting essence-blood；Intestine moistening road. Main kidney yang deficiency；The sexual impotence of asthenia of essence and blood；Seminal emission；Nebulousurine；The frequent micturition heeltap；Lumbago flaccidity of the lower limbs；Tinnitus Mesh flower；Menstruation is spread out the phase；Infertility；Dryness of the intestine constipation；Herba Cistanches, the key medicine of nourishing kidney replenishing vital essence and blood.Sweet Energy heat extraction invigorating middle warmer, acid can enter liver, the nourishing kidney of salty energy, and kidney liver is cloudy, and cloudy gas is grown, then the consumptive fever of the five internal organs From moving back.Kidney liver foot, then essence and blood day contains, and essence and blood is contained the most sub.Gynecological mass in abdomen, the disease appearing in blood system, blood is contained Then going, capable then lump in the abdomen disappears certainly.Bladder is empty, then evil visitor, must mend then that pathogen is from dissipating, and lumbago is from stopping. Clothes then fertilizer is good for and is made light of one's life by commiting suicide for a long time, and the effect of kidney tonifying liver replenishing vital essence and blood also, controls dysentery if saying, and slides the meaning with intestinal stasis relieving, This also can not say also.Main five kinds of strain and seven kinds of impairment, invigorating middle warmer, except stem invasion by pathogenic cold burning pain, foster the five internal organs, reinforcing YIN-essence, Benefit vital essence, gynecological mass in abdomen.The present invention, with its reinforcing YIN-essence tonifying YANG, five kinds of strain and seven kinds of impairment processed, intestine moistening road, controls waist Flaccidity of the lower limbs effect bitterly, vigorate qi and replenish the blood is invigorated blood circulation, is improved milch cow nonspecific immunity power, the tonification gas such as the Radix Astragali that are in harmonious proportion The taste of blood medicine is greasy, improves gastrointestinal function, is important ancillary drug.

Radix Ophiopogonis: hardship sweet, micro-, is slightly cold.Return lung, the heart, stomach warp.YIN nourishing and the production of body fluid promoting, nourishing the lung to arrest cough: use Few thirsty, dry cough spitting of blood in Tianjin of lung-stomach yin deficiency；The palpitation and being susceptible to fright of insufficiency of heart-YIN and calentura later stage thermal burn Body fluid etc. are demonstrate,proved.Join Radix Adenophorae (Radix Glehniae), Bulbus Fritillariae Cirrhosae can control deficiency of lung-YIN dry cough.With Fructus Mume, Fructus Schisandrae Chinensis, etc. compatibility treatment Gastric juice is lost, xerostomia gastric heat disease.Clearing away heat and nourishing YIN: for thermal burn stomach-Yin, thirsty and dry pharynx, constipation due to dry stool Deng.Clear away heart-fire relieving restlessness: disturbs and the heart-nutriment for epidemic febrile disease pathogenic heat, insufficiency of heart-YIN, dysphoria and insomnia, cardiopalmus, the heart Flurried etc., moistening lung and nourishing throat: hindering for lung-heat the moon, pharyngodynia with dryness, hoarseness and aphonia, dryness of the tongue are thirsty.This Invention Radix Ophiopogonis mainly by its YIN nourishing and the production of body fluid promoting, heat clearing away effect, function of spleen and stomach regulating function, strengthens cow rumen and moves Power, clearing stomach intestinal deficiency-heat, alleviate the heat stress injury to milch cow simultaneously；Improve immunity, strengthen disease-resistant Ability.

The Radix Paeoniae Alba: sweet in the mouth, acid, cold nature, has the effect nourished blood；Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, hold back Cloudy hidroschesis.For dizziness of having a headache, hypochondriac pain, suffer from abdominal pain, limb pain twin, blood deficiency and yellow complexion, menoxenia, Spontaneous perspiration, night sweat.For hepatitis: the Radix Paeoniae Alba has protecting the liver, drops the effect of enzyme, often and Radix Bupleuri, Radix Angelicae Sinensis, The compatibilities such as Radix Rehmanniae, it is believed that the Radix Paeoniae Alba can promote albuminous synthesis.Can be with depressed liver-energy dispersing and QI regulating, easing the affected liver Nourish blood, delay middle pain relieving, suppressing the hyperactive liver yin fluid astringing, be usually used in the distending pain in the chest and hypochondrium caused by incoordination between the liver and stomach, epigastric pain, Menoxenia, abdominal pain during menstruation, metrorrhagia, and spontaneous perspiration, night sweat, the disease such as headache, dizziness.

The Radix Paeoniae Alba also regulate immunity, antiinflammatory etc. effect, clinical treatment chronic gastritis, peptic ulcer, Chronic enteritis, irritable colon syndrome, acute icterohepatitis, chronic hepatitis B, hepatic fibrosis Have necessarily with liver cirrhosis, treatment sciatica, headache, epilepsy, coronary heart disease, rheumatoid arthritis Effect.Effect of the Radix Paeoniae Alba and effect mainly antibacterial pain relieving.The Radix Paeoniae Alba of the present invention is mainly by its two aspects merit Can: 1. blood-enriching and blood-promoting circulation together with the medicine such as Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Radix Glycyrrhizae, assist the Radix Astragali, qi and blood tonifying, Improve the immunologic function of milch cow, strengthening vital QI to eliminate pathogenic factors；2. with its easing the affected liver yin fluid astringing, depressed liver-energy dispersing and QI regulating and slow middle pain relieving Effect, solves the poison of liver and gall altogether and discharges metabolic toxicities and exogenous have with Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei etc. Poison harmful substance, meanwhile, the Radix Paeoniae Alba can alleviate the various discomfort of abdominal part, improves the comfort of milch cow, has It is beneficial to lactogenic and repair tissue damage.

Fructus Crataegi: acid is sweet, tepor.Enter spleen, stomach, Liver Channel.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.It it is spleen invigorating Appetizing, relieving dyspepsia, the good medicine of phlegm reduction of blood circulation promoting, the disease such as, hernia, blood stasis full to chest and diaphragm spleen, amenorrhea There is good curative effect, there is the effects such as blood fat reducing, blood pressure, heart tonifying, arrhythmia simultaneously.Modern doctor Learn research: Fructus Crataegi all has facilitation to non-specific and specific immune function.Fructus Crataegi can significantly increase Add mouse thymus and spleen weight, serum lysozyme content, improve serum coagulation antibody titre, T lymph Cell transformation rate and periphery blood T lymphocyte percentage rate.Fructus Crataegi is to mouse red blood cell immunoadhering functions Also there is facilitation.The present invention mainly with its promoting digestion and invigorating the stomach, circulation of qi promoting scattered silt and improve efficacy of immunity, All medicines are assisted to play functions of prevention and health care.Fry to burned black in processing, decrease and digestive tract is stimulated, increase Having added prevention digestive tract hemorrhage, repaired effect of damage, that sends out the grainsick of milch cow and mixing rushes down Dysentery has good therapeutical effect, has well effect to protection cud technical ability with digestion to mucosa.

Semen Raphani: acrid in the mouth, sweet, property is put down.Return lung, spleen, stomach warp.Function helps digestion de-swelling, sending down the abnormal ascending QI Expectorant.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.Semen Raphani Merit, be longer than promoting the circulation of QI.Life can rise, ripe energy fall, rises and then tells wind-phlegm, and dispersing wind and cold sends out skin ulcer rash；Fall is then Determining phlegm dyspnea cough, adjust weight after dysentery, interior pain, is all the effect of promoting the circulation of QI.

Fang Zhongyong Semen Raphani (parched), with its de-swelling that helps digestion, lowering the adverse-rising QI to resolve phlegm, gastrointestinal upset of releiving, logical tune stomach Intestinal.With the medicine such as Fructus Crataegi, Pericarpium Citri Reticulatae, jointly assist a ruler in governing a country in principal agent spleen invigorating reason (gastrointestinal to lead to for), righting Eliminating evil.

Cacumen Platycladi: bitter in the mouth, puckery, cold in nature.Return lung, liver, spleen channel.Function cooling blood for hemostasis, preventing phlegm from forming and stopping coughing, Growing and blacking hair.For spitting blood, epistaxis, spitting of blood, to have blood in stool, metrostaxis, cough due to lung-heat, heat in blood takes off Send out, early whitening of beard and hair.The present invention repairs cud and injury to alimentary tract in order to cooling blood for hemostasis, safeguards digestion machine Can be normal.

Radix Et Rhizoma Rhei: bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Heat and toxic materials clearing away, clearing away heat-fire, Removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dampness removing jaundice eliminating.Stagnating constipation for excess-heat, heat in blood tells nosebleed, and conjunctival congestion is swallowed Swollen, carbuncle furuncle, abdominalgia with intestinal abscess, blood stasis amenorrhea, postpartum stagnation, traumatic injury, hygropyretic dysentery, Jaundice dark coloured urine, stranguria, edema；Its removing pathogenic heat from blood and toxic substance from the body of the present invention, eliminating blood stasis and inducing menstruation, the merit such as dampness removing jaundice eliminating Effectiveness is in prevention mastopathy, and coordinates the clear dampness-heat in the liver and gallbladder of Herba Artemisiae Scopariae, Fructus Gardeniae, and detoxication and toxicant eliminating function improves machine Body immunity.

Fructus Gardeniae: heat clearing away, pathogenic fire purging, removing heat from blood.Control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, mesh Red, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprain and swell and ache.In side Fructus Gardeniae with Radix Et Rhizoma Rhei, Herba Artemisiae Scopariae clear dampness-heat in the liver and gallbladder jointly, removing pathogenic heat from blood and toxic substance from the body, auxiliary principal agent, on the basis of strengthening the body resistance, is dispelled Pathogenic heat, improves immunity of organisms.

Herba Artemisiae Scopariae: meridian distribution of property and flavor: bitter, pungent, is slightly cold.Return spleen, stomach, liver, gallbladder meridian.Function heat clearing away profit Wet；Jaundice eliminating.Cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis etc..Medicine Pharmacological research has function of gallbladder promoting, liver function protecting, and antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, coronary dilating etc. acts on. In the present invention, by its clearing away heat-damp and promoting diuresis, hepatic cholagogic effect, and Fructus Gardeniae, the common hepatoprotective of Radix Et Rhizoma Rhei, Dispelling toxicity, detoxicating, releases the noxious substance infringement to liver in metabolic toxicities and feedstuff, and all medicines is the completeest Become strengthening the body resistance, dispelling toxicity, detoxicating, improve immunity of organisms, prevent disease, improve the work of production performance With.

Unguis Sus domestica: salty in the mouth, cold nature.Return stomach, large intestine channel.Eliminating phlegm to relieve asthma, removing toxic substances and promoting granulation.For Cough is panted, acute appendicitis, anal fistula, the hernia swelling and hanging down of either of the testes, tinea capitis, chilblain.Its salty in the mouth, property is put down, nontoxic, Start with Foot yangming Channel, can clearing away heat and cooling blood, circulation of qi promoting is by silt, enriching yin and nourishing kidney.Unguis Sus domestica has preferably promotion Galactopoiesis function, contrast difference is the most notable with Squama Manis.Squama Manis and Unguis Sus domestica high dose all can not With degree make abscess average diameter reduce, weight in wet base alleviates, prompting high dose Unguis Sus domestica equal with Squama Manis Can limit to, to reduce vermiform appendix lump, i.e. eliminating carbuncle evacuation of pus effect similar；Squama Manis and Unguis Sus domestica all can make greatly Mus abscess of appendix pathological process develops to recovery from illness direction, and Unguis Sus domestica high dose group is similar with Squama Manis effect Seemingly, in, low dose group effect more weak；Each medication group all can improve abscess of appendix rat to some extent Phagocytic activity of leukocytes, each medication group leukocytes phagocytic percentage rate is above model control group.This Result explanation is used at removing pus and relieving carbuncle, and Unguis Sus domestica is like alternative Squama Manis, its antiinflammatory action and enhancing The immunologic function of body is relevant.More research all proves, Unguis Sus domestica is to lactogenesis and acute mastitis treatment side The treatment and prevention effect in face is similar with Squama Manis, and the present invention is by its lactogenesis function, as drawing of full side The medicine of warp, makes the property of medicine move towards mammary system, plays the reparation to injury of mammary gland and facilitation；Meanwhile, Process stir-fry with after steeping in wine, enhance its lactogenesis blood circulation promoting and blood stasis dispelling removing pus and relieving carbuncle function and (also improve its biological utilisation Degree), soak with vinegar, strengthen it and hold back liver yin nourishing, strengthen body immunity effect.

In the present invention, the Radix Astragali, with invigorating QI to consolidate the body surface resistance, carries all medicine strengthening vital QI to eliminate pathogenic factors, by improving immunity of organisms, Reach to prevent mammitis of cow morbidity effect, therefore consumption is monarch drug greatly；Rhizoma Atractylodis Macrocephalae invigorating spleen to remove dampness, Radix Codonopsis Replenishing QI to invigorate the spleen, Chinese angelica blood supplementing and blood, Radix Rehmanniae Preparata are enriched blood yin nourishing, Radix Ophiopogonis replenishing YIN and removing heat, and Herba Cistanches reinforcing YIN-essence is strengthened Sun, vigorate qi and replenish the blood is invigorated blood circulation, is improved milch cow nonspecific immunity power, jointly assists principal agent qi and blood tonifying, is good for Spleen stomach function regulating, raising body health level, be ministerial drug altogether；Semen Raphani, Pericarpium Citri Reticulatae, Herba Artemisiae Scopariae, Fructus Crataegi, side Cacumen Platycladi (Cacumen Biotae), Radix Et Rhizoma Rhei, Fructus Gardeniae, the Radix Paeoniae Alba etc., respectively regulating qi-flowing for strengthening spleen, clearing away heat-fire, improve digestive system merit Energy, clear dampness-heat in the liver and gallbladder, dispelling toxicity, detoxicating, jointly assist a ruler in governing a country principal agent and complete to improve immunity of organisms, diseases prevention etc. Function, is adjuvant drug altogether；In Radix Glycyrrhizae replenishing QI to invigorate the spleen, sweet mitigation, solve sore swollen toxin and coordinating the actions of various ingredients in a prescription, Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping, and all medicines can be led to amount to disease institute；Unguis Sus domestica is to lactogenesis and breast Treatment and prevention effect in terms of carbuncle treatment is similar with Squama Manis, and the bootable property of medicine moves towards mammary system, Playing the medicine of tying-in in the reparation to injury of mammary gland and facilitation, the side of being, three medicines complete to be in harmonious proportion jointly All medicine property of medicine also guides its function moving towards mammary system, altogether for making medicine in side.All medicines share, QI invigorating Nourish blood, invigorate blood circulation, regulate the flow of vital energy, soothing liver and strengthening spleen and middle heat clearing away.By vital base and primordial QI consolidating, harmonizing yingfen and weifen, carry High immunity of organisms, reach to improve milk cow health, prevention mastitis morbidity, reduce somatic number, Anti-stress, the purpose of raising production performance.

One, the preparation of Chinese medicine preparation of the present invention

Embodiment 1

According to mass parts weighing following components: the Radix Astragali 180 parts, Radix Codonopsis 60 parts, Radix Angelicae Sinensis 60 parts is ripe 60 parts of ground, the Rhizoma Atractylodis Macrocephalae 50 parts, Pericarpium Citri Reticulatae 60 parts, 30 parts of Radix Glycyrrhizae, Rhizoma Chuanxiong 30 parts, Herba Cistanches 40 parts, Radix Ophiopogonis 30 parts, the Radix Paeoniae Alba 30 parts, Fructus Crataegi 100 parts, Semen Raphani 60 parts, Cacumen Platycladi 80 parts, Radix Et Rhizoma Rhei 10 parts, Fructus Gardeniae 20 parts, Herba Artemisiae Scopariae 60 parts, Unguis Sus domestica 60 parts.Load weighted Radix Rehmanniae Preparata is put into frying pan, Gaza, fries 20-40min with atomic fire, treats that quality is more crisp, and sieve removes sand, cools standby；By weighing well Fructus Crataegi enter frying pan, slow fire is fried to the most burned black as degree, take out cool standby；By load weighted Semen Raphani, Entering frying pan, low baking temperature is fried to light yellow complexion, has peat-reek degree of being, taking-up to cool standby；By load weighted Radix Et Rhizoma Rhei, squirts with 40 degree of wine, then slow fire fried dry, and taking-up cools standby；By load weighted Unguis Sus domestica, First soak 30 minutes with 40 degree of wine, pull out, drain excessive moisture, put in frying pan, with fine sand slow fire With frying, frying to brown and crisp, take out, sieve removes fine sand, soaks with vinegar while hot, then pulls out, dry standby； The medicine cooked is mixed with weighing other components obtained, pulverizes standby with 80 mesh pulverizers；Take The comminuting matter crushed 100 parts, adds Semen Maydis powder 5 parts, glucose 1 part, and add water 30% mixing, Add conventional strain, first oxygen consumption to ferment 60 hours, then, load hermetic container, anaerobic fermentation one More than week, then, dry in the shade, add carrier, pack standby.Wherein, carrier is mainly every gram containing 2,000,000,000 The yeast product of cfu, is 7:3 with the Chinese medicine ratio made.

Embodiment 2

According to mass parts weighing following components: the Radix Astragali 150 parts, Radix Codonopsis 80 parts, Radix Angelicae Sinensis 40 parts is ripe 80 parts of ground, the Rhizoma Atractylodis Macrocephalae 30 parts, Pericarpium Citri Reticulatae 80 parts, 15 parts of Radix Glycyrrhizae, Rhizoma Chuanxiong 45 parts, Herba Cistanches 30 parts, Radix Ophiopogonis 50 parts, the Radix Paeoniae Alba 30 parts, Fructus Crataegi 150 parts, Semen Raphani 40 parts, Cacumen Platycladi 100 parts, Radix Et Rhizoma Rhei 5 parts, Fructus Gardeniae 30 parts, Herba Artemisiae Scopariae 40 parts, Unguis Sus domestica 80 parts；Load weighted Radix Rehmanniae Preparata is put into frying pan, Gaza, fries 20min with atomic fire, treats that quality is more crisp, and sieve removes sandy soil, cools standby；By weighing well Fructus Crataegi enter frying pan, slow fire is fried to the most burned black as degree, take out cool standby；By load weighted Semen Raphani, Entering frying pan, low baking temperature is fried to light yellow complexion, has peat-reek degree of being, taking-up to cool standby；By load weighted Radix Et Rhizoma Rhei, squirts with 35 degree of wine, then slow fire fried dry, and taking-up cools standby；By load weighted Unguis Sus domestica, First soak 40 minutes with 35 degree of wine, pull out, drain excessive moisture, put in frying pan, with fine sand slow fire With frying, frying to brown and crisp, take out, sieve removes fine sand, soaks with vinegar while hot, then pulls out, dry standby； The medicine cooked is mixed with weighing other components obtained, pulverizes standby with 80 mesh pulverizers；Take The comminuting matter crushed 100 parts, adds Semen Maydis powder 5 parts, glucose 1 part, and add water 30% mixing, Add conventional strain, first oxygen consumption to ferment 48 hours, then, load hermetic container, anaerobic fermentation one More than week, then, dry in the shade, add carrier, pack standby.Wherein, carrier is mainly every gram containing 2,000,000,000 The yeast product of cfu, is 7:3 with the Chinese medicine ratio made.

Embodiment 3

According to mass parts weighing following components: the Radix Astragali 200 parts, Radix Codonopsis 40 parts, Radix Angelicae Sinensis 80 parts is ripe 40 parts of ground, the Rhizoma Atractylodis Macrocephalae 60 parts, Pericarpium Citri Reticulatae 40 parts, 45 parts of Radix Glycyrrhizae, Rhizoma Chuanxiong 15 parts, Herba Cistanches 50 parts, Radix Ophiopogonis 30 parts, the Radix Paeoniae Alba 50 parts, Fructus Crataegi 60 parts, Semen Raphani 80 parts, Cacumen Platycladi 60 parts, Radix Et Rhizoma Rhei 15 Part, Fructus Gardeniae 10 parts, Herba Artemisiae Scopariae 80 parts, Unguis Sus domestica 40 parts；Load weighted Radix Rehmanniae Preparata is put into frying pan, adds Sand, fries 40min with atomic fire, treats that quality is more crisp, and sieve removes sandy soil, cools standby；By load weighted Fructus Crataegi enters frying pan, and slow fire is fried to burned black as spending, and taking-up cools standby；By load weighted Semen Raphani, enter Frying pan, low baking temperature is fried to light yellow complexion, has peat-reek degree of being, taking-up to cool standby；By load weighted greatly Huang, squirts with 45 degree of wine, then slow fire fried dry, and taking-up cools standby；By load weighted Unguis Sus domestica, First soak 20 minutes with 45 degree of wine, pull out, drain excessive moisture, put in frying pan, with fine sand slow fire With frying, frying to brown and crisp, take out, sieve removes fine sand, soaks with vinegar while hot, then pulls out, dry standby； The medicine cooked is mixed with weighing other components obtained, pulverizes standby with 80 mesh pulverizers；Take The comminuting matter crushed 100 parts, adds Semen Maydis powder 5 parts, glucose 1 part, and add water 30% mixing, Add conventional strain, first oxygen consumption to ferment 72 hours, then, load hermetic container, anaerobic fermentation one More than week, then, dry in the shade, add carrier, pack standby.Wherein, carrier is mainly every gram containing 2,000,000,000 The yeast product of cfu, is 7:3 with the Chinese medicine ratio made.

Embodiment 4

According to mass parts weighing following components: the Radix Astragali 160 parts, Radix Codonopsis 50 parts, Radix Angelicae Sinensis 70 parts is ripe 50 parts of ground, the Rhizoma Atractylodis Macrocephalae 40 parts, Pericarpium Citri Reticulatae 45 parts, 20 parts of Radix Glycyrrhizae, Rhizoma Chuanxiong 25 parts, Herba Cistanches 35 parts, Radix Ophiopogonis 40 parts, the Radix Paeoniae Alba 40 parts, Fructus Crataegi 70 parts, Semen Raphani 50 parts, Cacumen Platycladi 70 parts, Radix Et Rhizoma Rhei 6 Part, Fructus Gardeniae 15 parts, Herba Artemisiae Scopariae 50 parts, Unguis Sus domestica 70 parts；Load weighted Radix Rehmanniae Preparata is put into frying pan, adds Sand, fries 25min with atomic fire, treats that quality is more crisp, and sieve removes sandy soil, cools standby；By load weighted Fructus Crataegi enters frying pan, and slow fire is fried to burned black as spending, and taking-up cools standby；By load weighted Semen Raphani, enter Frying pan, low baking temperature is fried to light yellow complexion, has peat-reek degree of being, taking-up to cool standby；By load weighted greatly Huang, squirts with 36 degree of wine, then slow fire fried dry, and taking-up cools standby；By load weighted Unguis Sus domestica, First soak 25 minutes with 36 degree of wine, pull out, drain excessive moisture, put in frying pan, with fine sand slow fire With frying, frying to brown and crisp, take out, sieve removes fine sand, soaks with vinegar while hot, then pulls out, dry standby； The medicine cooked is mixed with weighing other components obtained, pulverizes standby with 80 mesh pulverizers；Take The comminuting matter crushed 100 parts, adds Semen Maydis powder 4 parts, glucose 0.8 part, and add water 30% mixing, Add conventional strain, first oxygen consumption to ferment 50 hours, then, load hermetic container, anaerobic fermentation one More than week, then, dry in the shade, add carrier, pack standby.Wherein, carrier is mainly every gram containing 2,000,000,000 The yeast product of cfu, is 6:3 with the Chinese medicine ratio made.

Embodiment 5

According to mass parts weighing following components: the Radix Astragali 170 parts, Radix Codonopsis 70 parts, Radix Angelicae Sinensis 55 parts is ripe 70 parts of ground, the Rhizoma Atractylodis Macrocephalae 35 parts, Pericarpium Citri Reticulatae 65 parts, 25 parts of Radix Glycyrrhizae, Rhizoma Chuanxiong 35 parts, Herba Cistanches 45 parts, Radix Ophiopogonis 35 parts, the Radix Paeoniae Alba 35 parts, Fructus Crataegi 80 parts, Semen Raphani 45 parts, Cacumen Platycladi 90 parts, Radix Et Rhizoma Rhei 7 Part, Fructus Gardeniae 25 parts, Herba Artemisiae Scopariae 70 parts, Unguis Sus domestica 50 parts；Load weighted Radix Rehmanniae Preparata is put into frying pan, adds Sand, fries 30min with atomic fire, treats that quality is more crisp, and sieve removes sandy soil, cools standby；By load weighted Fructus Crataegi enters frying pan, and slow fire is fried to burned black as spending, and taking-up cools standby；By load weighted Semen Raphani, enter Frying pan, low baking temperature is fried to light yellow complexion, has peat-reek degree of being, taking-up to cool standby；By load weighted greatly Huang, squirts with 37 degree of wine, then slow fire fried dry, and taking-up cools standby；By load weighted Unguis Sus domestica, First soak 35 minutes with 37 degree of wine, pull out, drain excessive moisture, put in frying pan, with fine sand slow fire With frying, frying to brown and crisp, take out, sieve removes fine sand, soaks with vinegar while hot, then pulls out, dry standby； The medicine cooked is mixed with weighing other components obtained, pulverizes standby with 80 mesh pulverizers；Take The comminuting matter crushed 100 parts, adds Semen Maydis powder 6 parts, glucose 1.2 parts, and add water 30% mixing, Add conventional strain, first oxygen consumption to ferment 52 hours, then, load hermetic container, anaerobic fermentation one More than week, then, dry in the shade, add carrier, pack standby.Wherein, carrier is mainly every gram containing 2,000,000,000 The yeast product of cfu, is 6:2 with the Chinese medicine ratio made.

Embodiment 6

According to mass parts weighing following components: the Radix Astragali 190 parts, Radix Codonopsis 45 parts, Radix Angelicae Sinensis 50 parts is ripe 55 parts of ground, the Rhizoma Atractylodis Macrocephalae 45 parts, Pericarpium Citri Reticulatae 50 parts, 35 parts of Radix Glycyrrhizae, Rhizoma Chuanxiong 18 parts, Herba Cistanches 33 parts, Radix Ophiopogonis 45 parts, the Radix Paeoniae Alba 33 parts, Fructus Crataegi 90 parts, Semen Raphani 55 parts, Cacumen Platycladi 65 parts, Radix Et Rhizoma Rhei 8 Part, Fructus Gardeniae 13 parts, Herba Artemisiae Scopariae 75 parts, Unguis Sus domestica 55 parts；Load weighted Radix Rehmanniae Preparata is put into frying pan, adds Sand, fries 35min with atomic fire, treats that quality is more crisp, and sieve removes sandy soil, cools standby；By load weighted Fructus Crataegi enters frying pan, and slow fire is fried to burned black as spending, and taking-up cools standby；By load weighted Semen Raphani, enter Frying pan, low baking temperature is fried to light yellow complexion, has peat-reek degree of being, taking-up to cool standby；By load weighted greatly Huang, squirts with 38 degree of wine, then slow fire fried dry, and taking-up cools standby；By load weighted Unguis Sus domestica, First soak 23 minutes with 38 degree of wine, pull out, drain excessive moisture, put in frying pan, with fine sand slow fire With frying, frying to brown and crisp, take out, sieve removes fine sand, soaks with vinegar while hot, then pulls out, dry standby； The medicine cooked is mixed with weighing other components obtained, pulverizes standby with 80 mesh pulverizers；Take The comminuting matter crushed 100 parts, adds Semen Maydis powder 4.5 parts, glucose 0.9 part, and add water 30% mixing, Add conventional strain, first oxygen consumption to ferment 54 hours, then, load hermetic container, anaerobic fermentation one More than week, then, dry in the shade, add carrier, pack standby.Wherein, carrier is mainly every gram containing 2,000,000,000 The yeast product of cfu, is 6:4 with the Chinese medicine ratio made.

Embodiment 7

According to mass parts weighing following components: the Radix Astragali 155 parts, Radix Codonopsis 55 parts, Radix Angelicae Sinensis 65 parts is ripe 75 parts of ground, the Rhizoma Atractylodis Macrocephalae 55 parts, Pericarpium Citri Reticulatae 75 parts, 40 parts of Radix Glycyrrhizae, Rhizoma Chuanxiong 38 parts, Herba Cistanches 37 parts, Radix Ophiopogonis 33 parts, the Radix Paeoniae Alba 37 parts, Fructus Crataegi 110 parts, Semen Raphani 65 parts, Cacumen Platycladi 75 parts, Radix Et Rhizoma Rhei 9 Part, Fructus Gardeniae 17 parts, Herba Artemisiae Scopariae 55 parts, Unguis Sus domestica 45 parts；Load weighted Radix Rehmanniae Preparata is put into frying pan, adds Sand, fries 23min with atomic fire, treats that quality is more crisp, and sieve removes sandy soil, cools standby；By load weighted Fructus Crataegi enters frying pan, and slow fire is fried to burned black as spending, and taking-up cools standby；By load weighted Semen Raphani, enter Frying pan, low baking temperature is fried to light yellow complexion, has peat-reek degree of being, taking-up to cool standby；By load weighted greatly Huang, squirts with 39 degree of wine, then slow fire fried dry, and taking-up cools standby；By load weighted Unguis Sus domestica, First soak 27 minutes with 39 degree of wine, pull out, drain excessive moisture, put in frying pan, with fine sand slow fire With frying, frying to brown and crisp, take out, sieve removes fine sand, soaks with vinegar while hot, then pulls out, dry standby； The medicine cooked is mixed with weighing other components obtained, pulverizes standby with 80 mesh pulverizers；Take The comminuting matter crushed 100 parts, adds Semen Maydis powder 5.5 parts, glucose 1.1 parts, and add water 30% mixing, Add conventional strain, first oxygen consumption to ferment 58 hours, then, load hermetic container, anaerobic fermentation one More than week, then, dry in the shade, add carrier, pack standby.Wherein, carrier is mainly every gram containing 2,000,000,000 The yeast product of cfu, is 8:3 with the Chinese medicine ratio made.

Embodiment 8

According to mass parts weighing following components: the Radix Astragali 165 parts, Radix Codonopsis 65 parts, Radix Angelicae Sinensis 45 parts is ripe 65 parts of ground, the Rhizoma Atractylodis Macrocephalae 30 parts, Pericarpium Citri Reticulatae 70 parts, 18 parts of Radix Glycyrrhizae, Rhizoma Chuanxiong 40 parts, Herba Cistanches 43 parts, Radix Ophiopogonis 37 parts, the Radix Paeoniae Alba 45 parts, Fructus Crataegi 120 parts, Semen Raphani 75 parts, Cacumen Platycladi 85 parts, Radix Et Rhizoma Rhei 11 parts, Fructus Gardeniae 23 parts, Herba Artemisiae Scopariae 45 parts, Unguis Sus domestica 75 parts；Load weighted Radix Rehmanniae Preparata is put into frying pan, Gaza, fries 27min with atomic fire, treats that quality is more crisp, and sieve removes sandy soil, cools standby；By weighing well Fructus Crataegi enter frying pan, slow fire is fried to the most burned black as degree, take out cool standby；By load weighted Semen Raphani, Entering frying pan, low baking temperature is fried to light yellow complexion, has peat-reek degree of being, taking-up to cool standby；By load weighted Radix Et Rhizoma Rhei, squirts with 41 degree of wine, then slow fire fried dry, and taking-up cools standby；By load weighted Unguis Sus domestica, First soak 33 minutes with 41 degree of wine, pull out, drain excessive moisture, put in frying pan, with fine sand slow fire With frying, frying to brown and crisp, take out, sieve removes fine sand, soaks with vinegar while hot, then pulls out, dry standby； The medicine cooked is mixed with weighing other components obtained, pulverizes standby with 80 mesh pulverizers；Take The comminuting matter crushed 100 parts, adds Semen Maydis powder 4.3 parts, glucose 0.9 part, and add water 30% mixing, Add conventional strain, first oxygen consumption to ferment 70 hours, then, load hermetic container, anaerobic fermentation one More than week, then, dry in the shade, add carrier, pack standby.Wherein, carrier is mainly every gram containing 2,000,000,000 The yeast product of cfu, is 8:2 with the Chinese medicine ratio made.

Embodiment 9

According to mass parts weighing following components: the Radix Astragali 175 parts, Radix Codonopsis 75 parts, Radix Angelicae Sinensis 60 parts is ripe 45 parts of ground, the Rhizoma Atractylodis Macrocephalae 50 parts, Pericarpium Citri Reticulatae 55 parts, 28 parts of Radix Glycyrrhizae, Rhizoma Chuanxiong 20 parts, Herba Cistanches 47 parts, Radix Ophiopogonis 43 parts, the Radix Paeoniae Alba 47 parts, Fructus Crataegi 130 parts, Semen Raphani 60 parts, Cacumen Platycladi 95 parts, Radix Et Rhizoma Rhei 12 parts, Fructus Gardeniae 27 parts, Herba Artemisiae Scopariae 65 parts, Unguis Sus domestica 80 parts；Load weighted Radix Rehmanniae Preparata is put into frying pan, Gaza, fries 33min with atomic fire, treats that quality is more crisp, and sieve removes sandy soil, cools standby；By weighing well Fructus Crataegi enter frying pan, slow fire is fried to the most burned black as degree, take out cool standby；By load weighted Semen Raphani, Entering frying pan, low baking temperature is fried to light yellow complexion, has peat-reek degree of being, taking-up to cool standby；By load weighted Radix Et Rhizoma Rhei, squirts with 42 degree of wine, then slow fire fried dry, and taking-up cools standby；By load weighted Unguis Sus domestica, First soak 37 minutes with 42 degree of wine, pull out, drain excessive moisture, put in frying pan, with fine sand slow fire With frying, frying to brown and crisp, take out, sieve removes fine sand, soaks with vinegar while hot, then pulls out, dry standby； The medicine cooked is mixed with weighing other components obtained, pulverizes standby with 80 mesh pulverizers；Take The comminuting matter crushed 100 parts, adds Semen Maydis powder 4.7 parts, glucose 1.1 parts, and add water 30% mixing, Add conventional strain, first oxygen consumption to ferment 55 hours, then, load hermetic container, anaerobic fermentation one More than week, then, dry in the shade, add carrier, pack standby.Wherein, carrier is mainly every gram containing 2,000,000,000 The yeast product of cfu, is 7:2 with the Chinese medicine ratio made.

Embodiment 10

According to mass parts weighing following components: the Radix Astragali 185 parts, Radix Codonopsis 60 parts, Radix Angelicae Sinensis 75 parts is ripe 60 parts of ground, the Rhizoma Atractylodis Macrocephalae 60 parts, Pericarpium Citri Reticulatae 60 parts, 38 parts of Radix Glycyrrhizae, Rhizoma Chuanxiong 28 parts, Herba Cistanches 40 parts, Radix Ophiopogonis 47 parts, the Radix Paeoniae Alba 43 parts, Fructus Crataegi 140 parts, Semen Raphani 80 parts, Cacumen Platycladi 80 parts, Radix Et Rhizoma Rhei 13 parts, Fructus Gardeniae 20 parts, Herba Artemisiae Scopariae 80 parts, Unguis Sus domestica 65 parts；Load weighted Radix Rehmanniae Preparata is put into frying pan, Gaza, fries 37min with atomic fire, treats that quality is more crisp, and sieve removes sandy soil, cools standby；By weighing well Fructus Crataegi enter frying pan, slow fire is fried to the most burned black as degree, take out cool standby；By load weighted Semen Raphani, Entering frying pan, low baking temperature is fried to light yellow complexion, has peat-reek degree of being, taking-up to cool standby；By load weighted Radix Et Rhizoma Rhei, squirts with 43 degree of wine, then slow fire fried dry, and taking-up cools standby；By load weighted Unguis Sus domestica, First soak 30 minutes with 43 degree of wine, pull out, drain excessive moisture, put in frying pan, with fine sand slow fire With frying, frying to brown and crisp, take out, sieve removes fine sand, soaks with vinegar while hot, then pulls out, dry standby； The medicine cooked is mixed with weighing other components obtained, pulverizes standby with 80 mesh pulverizers；Take The comminuting matter crushed 100 parts, adds Semen Maydis powder 5.3 parts, glucose 1 part, and add water 30% mixing, Add conventional strain, first oxygen consumption to ferment 56 hours, then, load hermetic container, anaerobic fermentation one More than week, then, dry in the shade, add carrier, pack standby.Wherein, carrier is mainly every gram containing 2,000,000,000 The yeast product of cfu, is 7:4 with the Chinese medicine ratio made.

Two, clinical trial of the present invention and effect

1.1 experimental animals and feeding and management

Tested on October 1,1 day to 2014 August in 2014 Ningjin County of Hebei province refined milch cow of collection Plant is carried out.Age, parity, lactogenic milk that lactogenic natural law is close is chosen in 250 cows in milk Cattle 28, wherein latent mammitis positive cattle and healthy each 14 of cattle.It is divided into 4 according to test objective Group, often group 7: positive controls and normal healthy controls group feed conventional daily ration, positive interpolation group and strong Kang Tianjia group feeds the daily ration containing 100g Chinese medicine preparation of the present invention.Cattle feeds according to packet situation in test In different cowshed, feed every day 2 times, free choice feeding and drinking-water, same poultry raiser feed.In examination Test the beginning later moon (the 31st day), the time of two months (the 61st day), raise front sky respectively at early Abdomen is taken a blood sample stand-by in heparin sodium vacuum tube labelling；Gathering Spot detection milk sample send DHI center, Hebei province to examine Survey.

1.2 EXPERIMENTAL DESIGN

Test preliminary trial period is 1 month；From formal test on July 15 in 2014,61 days formal phases. To cow in milk packet numbering, point colony house during prerun；Milch cow is made to adapt to environment and daily ration.Different tests Group daily ration, in addition to whether containing Chinese medicine additive, uses same Diet Formula.

1.3 measure project and method

1.3.1 blood sampling and sample determination method

At the time point of regulation, jugular vein blood collection two parts on an empty stomach, every part of 4ml.A for centrifugal On machine 2000r/min be centrifuged 12min separate serum, automatic clinical chemistry analyzer detection glutamate pyruvate transaminase, Glutamic oxaloacetic transaminase, GOT, lactic acid dehydrogenase, albumin equal size；For blood pH's after a centrifugal treating Detection.

1.3.2 milk sample acquisition method and detection:

After predetermined time point, the milk sample mixing of every test cattle collection, take 40ml be placed in sampling bottle In, it is sent to Hebei DHI Spot detection.Milk yield according to testing result statistical test cattle, somatic cell, Butterfat percnetage, protein ratio.

1.4 data statistic analysis

Test data uses SPSS19.0 to carry out statistical analysis.P < 0.05 represents significant difference.

2 results and analysis

The impact on cow blood index of 2.1 Chinese medicine preparation of the present invention

By the content of enzyme relevant with mastitis in detection examination Ox blood serum, indirect reaction Chinese medicine of the present invention System adds the effect of agent.In different disposal group examination Ox blood serum, enzyme, albumin and pH change are as shown in table 1.

In table 1 different disposal group examination Ox blood serum, enzyme, albumin and pH change table

Note: the different letter representation significant difference (p < 0.05) of same column shoulder mark

As can be seen from Table 1, after the sick feeding Chinese medicine preparation feedstuff of the present invention of cattle interpolation group after January, The content of SA, GTP begins to decline, to content and the positive controls of 2nd month its SA, GPT There is significant difference (p < 0.05).With normal healthy controls group, healthy interpolation group contrast, basic recovery is normal. And SA, GPT content of normal healthy controls group gradually rose within experimental period, may be drawn with sweltering heat in summer The mastitis morbidity risen or heat stress are relevant.SA, GPT content of healthy interpolation group is relatively stable, table Bright Chinese medicine preparation of the present invention can improve the body toleration to heat stress.During whole test, The variable quantity of GOT, LDH is little, does not has significant difference between different groups.

Table 1 shows, normal healthy controls group, the blood pH of positive control are not changed in during testing substantially, Respectively 6.75, about 6.5；The blood pH of sick cattle interpolation group and healthy interpolation group is the most in rising trend, The blood pH of test sick cattle interpolation group after two months is close to normal healthy controls group.Chinese medicine preparation of the present invention is described Organismic internal environment can be effectively improved, improve pH value of body, be effectively increased body to heat stress and disease Sick resistivity.

The impact on milk cow production performance of 2.2 Chinese medicine preparation of the present invention

As can be seen from Table 2, healthy interpolation group and sick cattle interpolation group are after edible Chinese medicine preparation of the present invention Milking cow presents the trend gradually risen, and feeds average daily per unit area yield after two months and is respectively increased 0.80,2.08 Kilogram.It addition, the butterfat percnetage change of sick cattle interpolation group is little, protein ratio is brought up to by average 2.9% 3.3%, averagely improve 0.4 percentage point.The butterfat percnetage of healthy interpolation group is brought up to 3.72% by 3.3%, Averagely improve 0.42 percentage point；Protein ratio is brought up to 3.19 by 2.9, averagely improves 0.29 Percentage point.The somatic number of positive cattle interpolation group is in being decreased obviously trend (declining 36.5 ten thousand), and right According to group change inconspicuous (declining 4.3), healthy interpolation group and matched group somatic cell change are the most inconspicuous； Positive controls, the milk yield of normal healthy controls group all present downward trend；Between each group, butterfat percnetage does not has There is notable difference, and positive interpolation group and healthy interpolation group protein ratio after feeding Chinese medicine preparation are the most aobvious Write and improve.

Table 2 Chinese medicine preparation of the present invention affects table to different disposal group production performance

Note: the different letter representation significant difference (p < 0.05) of same column shoulder mark

3, conclusion

Result of the test shows, Chinese medicine preparation of the present invention can improve the average daily per unit area yield of cow in milk, significantly improves Breast index, controls the generation of mastitis, improves organismic internal environment, reduce acidosic generation；Improve Milch cow immunity of organisms, reduces somatic number, reduces heat stress in summer, improves milk cow production performance. Theory and practice basis is provided for opening up new efficient breeding technology.

Three, Chinese medicine preparation using effect of the present invention

Pasture, Huhehaote City on the 9th in 1:2010 November, 54 cattle, somatic cell weighted mean 540000/ml, latent mammitis cattle 67%, clinical mastitis cattle 14.8%.After medication, December prison on the 6th Survey result: somatic number weighted value 330,000/ml, latent mammitis 40%, clinical mastitis 0；Butterfat Before rate medication 3.35%, after medication 3.54%；Before protein ratio medication 3.01%, after medication 3.17%, Milk yield increases 0.8kg than matched group.

2: pasture, Beijing: 2012 March, 110 cattle were when being cooked DHI detection, found that cows are put down All somatic numbers are up to 880,000/ml.Outside eliminating wherein 11 subclinical mastitis cattle, remaining 99 The somatic cell of cattle is all at 720,000/more than ml.Then application treatment by Chinese herbs scheme: (1) at holocriny dairy herd Middle every day every throws in Chinese medicine preparation of the present invention 30 grams, is disposably dropped in TMR feedstuff, as Health care prevention.(2) somatic cell is the cattle of 60-200 ten thousand/more than ml, and every day every, dosage 50 grams, made For prophylactic treatment.After offeing medicine 20 days, 113, cattle farm cattle has participated in the detection of DHI at the beginning of 4 months, detection Result: cows average body cell number is 260,000/ml.Get rid of and leave over last month and 5 newborn somatic cells Outside the cattle of 100-200/ml ten thousand/ml, remaining 108 cattle average body cell is 17.5 ten thousand.June is examined Survey result: only 3 examples of 60-80 ten thousand/ml, in cows somatic cell about 100,000 account for 50%, 200,000 Left and right account for 30%, average body cell number 160,000, cows body condition is good, and mastitis sickness rate is 0. To by the end of December, the average 29kg/d of cows per unit area yield, improves 3kg than March.

Claims (10)

1. improve a preparation method for the Chinese medicine preparation of milch cow immunity, prevention mammitis of cow, its It is characterised by, Radix Rehmanniae Preparata, Fructus Crataegi, Semen Raphani, Radix Et Rhizoma Rhei, Unguis Sus domestica are concocted respectively, then will These materials after the process of preparing Chinese medicine and the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Rhizoma Chuanxiong, meat desert Pulverize after Rong, Radix Ophiopogonis, the Radix Paeoniae Alba, Cacumen Platycladi, Fructus Gardeniae, Herba Artemisiae Scopariae mixing, obtain comminuting matter, then Adding Semen Maydis powder, glucose, water mix homogeneously in comminuting matter, add zymocyte, first oxygen consumption is sent out Ferment 48-72h, the most again anaerobic fermentation more than 1 week, dry in the shade, add carrier, is improved milch cow immunity Power, the Chinese medicine preparation of prevention mammitis of cow.

The most according to claim 1 a kind of improve milch cow immunity, prevention mammitis of cow in The preparation method of medicine preparation, it is characterised in that each raw material of Chinese medicine is prepared by following parts by weight: the Radix Astragali 150-200 part, Radix Codonopsis 40-80 part, Radix Angelicae Sinensis 40-80 part, Radix Rehmanniae Preparata 40-80 part, Rhizoma Atractylodis Macrocephalae 30-60 part, Pericarpium Citri Reticulatae 40-80 part, Radix Glycyrrhizae 15-45 part, Rhizoma Chuanxiong 15-45 part, Herba Cistanches 30-50 part, Radix Ophiopogonis 30-50 Part, Radix Paeoniae Alba 30-50 part, Fructus Crataegi 60-150 part, Semen Raphani 40-80 part, Cacumen Platycladi 60-100 part, Radix Et Rhizoma Rhei 5-15 part, Fructus Gardeniae 10-30 part, Herba Artemisiae Scopariae 40-80 part, Unguis Sus domestica 40-80 part.

The most according to claim 1 a kind of improve milch cow immunity, prevention mammitis of cow in The preparation method of medicine preparation, it is characterised in that Radix Rehmanniae Preparata is concocted and included: is placed in marmite by Radix Rehmanniae Preparata, adds Entering sand, fry 20-40min under the conditions of 100-150 DEG C, sieve removes sand, cools.

The most according to claim 1 a kind of improve milch cow immunity, prevention mammitis of cow in The preparation method of medicine preparation, it is characterised in that the process of preparing Chinese medicine of Fructus Crataegi includes: Fructus Crataegi is placed in marmite, slowly Fire is fried to burned black, cools.

The most according to claim 1 a kind of improve milch cow immunity, prevention mammitis of cow in The preparation method of medicine preparation, it is characterised in that the process of preparing Chinese medicine of Semen Raphani includes: Semen Raphani is placed in marmite, Fry under the conditions of 100-150 DEG C to Semen Raphani seed surplus color blackout, savory spilling, cool.

The most according to claim 1 a kind of improve milch cow immunity, prevention mammitis of cow in The preparation method of medicine preparation, it is characterised in that the process of preparing Chinese medicine of Radix Et Rhizoma Rhei includes: by Radix Et Rhizoma Rhei, uses 35-45 degree Wine squirts, then slow fire fried dry, cools.

The most according to claim 1 a kind of improve milch cow immunity, prevention mammitis of cow in The preparation method of medicine preparation, it is characterised in that the process of preparing Chinese medicine of Unguis Sus domestica includes: first with 35-45 degree steeping in wine Bubble 20-40min, pulls out, drains excessive moisture, put in frying pan, with fine sand under the conditions of 120-180 DEG C With frying, frying to brown and crisp, take out, sieve removes fine sand, soaks 5-7min with vinegar while hot, then pulls out, dries in the air Dry.

The most according to claim 1 a kind of improve milch cow immunity, prevention mammitis of cow in The preparation method of medicine preparation, it is characterised in that comminuting matter, Semen Maydis powder, glucose, the weight of water Portion rate is 100:(4-6): (0.8-1.2): (28-32).

The most according to claim 1 a kind of improve milch cow immunity, prevention mammitis of cow in The preparation method of medicine preparation, it is characterised in that described zymocyte be mass ratio be the wine brewing ferment of 10:1 Female bacterium and bacillus subtilis, the addition of described saccharomyces cerevisiae is the 1-1.2% of comminuting matter.

The most according to claim 1 a kind of improve milch cow immunity, prevention mammitis of cow The preparation method of Chinese medicine preparation, it is characterised in that described carrier is yeast product, carrier and pulverizing The weight ratio of material is (6-8): (2-4), and described yeast product is by by the Semen sojae atricolor of 55-65% The Semen Maydis powder of bean cake and 35-45% with yeast by fermentation, dry, and obtains yeast product by product.