CN103478508B - Chinese medicinal composition and feed for improving chicken immunity and preparation method of composition and feed - Google Patents

Abstract

The invention discloses a feed for improving chicken immunity. The feed is characterized by comprising the following raw materials: corns, soybean meal, wheat, rice bran meal, a vitamin premix, a microelement premix, common salt, calcium bicarbonate, an antioxidant and a Chinese medicinal additive. The feed disclosed by the invention has the beneficial effects that the feed containing a Chinese medicinal composition can overcome various defects of Chinese medicines and Western medicine in the prior art, the immunity and productivity of chickens are improved, and the feed has the advantages of no toxic or side effect, less possibility of relapse, no medicinal hazards and the like.

Description

For improving the Chinese medicine composition, feed and preparation method thereof of chicken immunity

Technical field

The present invention relates to the mixed feed of chicken, particularly a kind of Chinese medicine composition, feed and preparation method thereof for improving chicken immunity.

Background technology

Immunity is self defense mechanism, is any foreign matter (virus, bacterium etc.) identifying and eliminate external intrusion; Process is old and feeble, damage, the ability of mutant cell and virus infected cell in the own cells of dead, sex change and identification and handling body.Immunology Today is thought, immunity is the physiological reaction identifying and get rid of " dissident ".

All the fashion in various bird flu today that China's poultry husbandry is flourish.The first-selection for preventing and treating infectious disease and parasitic disease is remained at chemicalses such as the various antibiotic of application.This not only causes the appearance of a large amount of drug-fast bacteria, worm strain, and residual in causing chemicals in various chicken and products thereof, bring very big infringement to public health and food security, more do not meet the food consumption trend of people's " high-quality, low medicine residual, green non-pollution ".The consumption that livestock products will meet people requires just to find a kind of safe production model, and to raise be first be vital link.As can be seen here, find one not only safe and effective but also alternative antibiotic medicine seem particularly important.

Animal immune system is that animal occurs in germline and evolves gradually in ontogenetic process and improve, and being the organization that body performs immunologic function, is the material base producing immune response.Animal immune system is made up of immune organ, immunocyte and immune molecule.All participation immune responses or the cell relevant to immune response are referred to as immunocyte.According to they function and effect mechanism in immune response, immunocompetent cell and the large class of immune accessory cell two can be divided into.In addition also have some other cells, such as K cell, NK cell, granulocyte, red blood cell etc., also take part in certain some the specific link in immune response.

In recent years, in fowl produces, ubiquity vaccine immunization preventive effect is bad, and dosage strengthens gradually and does not still reach desirable treatment and preventive effect, this causes livestock and poultry body's immunity to decline due to drug abuse a large amount of for a long time and irrational vaccine inoculation, particularly at a low ebb the or holddown of the immunocyte such as lymphocyte, macrophage; The fast development of aquaculture, the food of let us is abundanter, but due to the deterioration of breeding environment and antibiotic abuse, causes cultivated animals anti-adversity ability, immunocompetence, anti-stress ability to reduce.And the decline of the production efficiency brought by animal inferior health, dead, disability rate raises, and causes aquaculture cost to strengthen; Autoimmunity low, to the antibiotic abuse that disease-susceptible humans causes out, bacterial resistance bacterium property is caused to strengthen, us are made to have to again pay close attention to animal health, adopt an effective measure to the harm of human health etc. these problems, do health-care feed, strengthen animal daily health caring, improve animal autoimmunity ability and make China's feed industry and aquaculture go on the road of Sustainable Healthy Development.The effect that animal health plays, impels animal body to be transformed by the direction of sub-health state to health exactly, stops it to transform to the direction of disease, does not make animal occur clinical symptoms or reduces the probability of animal morbidity.The process of physical health is a kind of process prevented trouble before it happens, and is a kind of gradual conditioning.When the every function of body is all in animated period, when body is in the pink of condition, health products effect is also not obvious, but when body is in sub-health state or physiological function decline, autoimmunity declines, and during to disease-susceptible humans, health-care effect will display.Chemicals immunopotentiator also existing all in various degree reduces body production performance, causes toxic and side effect and medicament residue, and the drawback such as be detrimental to health.

Chinese medicine is the rarity of China, existing long history, has again unique curative effect.Chinese medicine is natural animals and plants or mineral matter, and itself, containing abundant vitamin, mineral matter and protein, can supplement the nutrients, the effect having again growth promotion, strengthen domestic animal physique, improve body resistance against diseases.Motherland's traditional medicine just proposed famous " strengthening vital QI to eliminate pathogenic factors " principle of reatment before over thousands of year." just " just refer to Abwehrkraft des Koepers, " heresy " refers to paathogenic factor.With modern medicine language, strengthen human body immune function exactly, the invasion and attack of paathogenic factor can be resisted.Half a century, the veterinarian of China has opened up the new application of Chinese medicine, implements new study route, defines new production technology.As the development of colony's medication of herbal medicine and feed addictive, herbal medicine regulate animal immune function as health products, herbal medicine and on the new technology of the herbal medicine such as impact, ultramicro grinding of animal microecological and the application etc. of biotechnology in Producing medicinal herbs.

Chinese herbal medicine has drawn from nature, and the herbal medicine with severe toxicity is few, and uses clinically and compare specification, therefore Chinese herbal medicine can than Chinese patent drug and Western medicine safer, respond well for improving chicken immunity.Because Chinese herbal medicine has the dual-use function of nutrition and health care, Chinese medicine under different conditions, for different objects, the effect promoting or suppress body's immunity can be shown, this is that the unique and complex property of medicine of Chinese medicine determines, also be the imbody of differentiation of tcm viewpoint, in livestock and poultry cultivation, use Chinese medicine immunity enhancer improve the immune level of body and be anti-parasitic-infectiously subject to common concern.

Summary of the invention

Technical problem to be solved by this invention is, a kind of feed improving chicken immunity is provided, according to the physilogical characteristics of chicken, in the daily ration of chicken, the appropriate Chinese medicine additive adding scientific formula, is effectively improving immunity, the generation of keeping off infection property disease, strengthen invasive organism and parasitic resistance, improve survival rate, while growth promoting effects, good palatability, bioavilability is high.

In order to realize foregoing invention object, the invention provides a kind of feed for improving chicken immunity, described feed comprises following raw material: corn, dregs of beans, wheat, rice bran meal, vitamin premix, microelement pre-mix material, salt, calcium bicarbonate, antioxidant and Chinese medicine additive.

Described feed can be made up of the raw material of following ratio of weight and number: corn 200-400 part, dregs of beans 250-433 part, wheat 50-140 part, rice bran meal 50-170 part, vitamin premix 5-9 part, microelement pre-mix material 5-8 part, salt 2-6 part, calcium bicarbonate 5-9 part, antioxidant 2-7 part and Chinese medicine additive 5-15 part.

Described Chinese medicine additive is made up of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 10-34 part, Chinese cassia tree 10-30 part, Ligusticum wallichii 10-36 part, Amomum cardamomum 10-28 part, common spiderflower root 10-45 part, flexuose bittercress herb and seed 13-32 part, oiltea camellia seed 13-29 part, Huang 16-28 part over sixty years of age, the blue 8-45 part of thumb, mile swertia herb 13-40 part, root of herbaceous peony 13-45 part, flos caryophylli 17-40 part, fore-telling mustard 10-24 part, testis et penis canitis 14-23 part, faenum graecum 8-38 part and HERBA EPIMEDII 17-34 part.

Described Chinese medicine additive can be made up of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 15-30 part, Chinese cassia tree 13-25 part, Ligusticum wallichii 16-31 part, Amomum cardamomum 14-22 part, common spiderflower root 19-35 part, flexuose bittercress herb and seed 18-27 part, oiltea camellia seed 18-21 part, Huang 19-25 part over sixty years of age, the blue 17-32 part of thumb, mile swertia herb 19-26 part, root of herbaceous peony 21-34 part, flos caryophylli 20-38 part, fore-telling mustard 13-21 part, testis et penis canitis 17-21 part, faenum graecum 17-31 part and HERBA EPIMEDII 19-31 part.

Described Chinese medicine additive can also be made up of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 21 parts, Chinese cassia tree 18 parts, Ligusticum wallichii 23 parts, Amomum cardamomum 18 parts, common spiderflower root 25 parts, flexuose bittercress herb and seed 23 parts, oiltea camellia seed 19 parts, yellow over sixty years of age 21 parts, blue 25 parts of thumb, mile swertia herb 23 parts, the root of herbaceous peony 27 parts, flos caryophylli 29 parts, fore-telling 17 parts, mustard, testis et penis canitis 19 parts, faenum graecum 24 parts and HERBA EPIMEDII 25 parts.

The preparation method of described Chinese medicine additive comprises the following steps:

The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;

Second step, the first step obtained powder and add in cold water and soak 24 hours ~ 36 hours, with slow fire boiling, decocting time is 2 hours ~ 3 hours, decoction liquor is filtered, obtain the first filtrate, the quality of the water added is 3 ~ 5 times of the powder quality that the first step obtains;

3rd step, second step is filtered the filter residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each to decoct 1 hour ~ 2 hours, filter and merge filtered fluid, obtaining the second filtrate, the quality of the water added and identical in second step;

4th step, the first filtrate and the second filtrate merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, ensure that EAT is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, be ground into 200 order ~ 400 orders subsequently, obtain Chinese medicine composition powder.

In order to better realize foregoing invention object, present invention also offers a kind of preparation method of the feed for improving chicken immunity, described preparation method comprises the following steps:

The first step, the preparation of described Chinese medicine composition additive;

Second step, feed vector is ground into 100 order ~ 200 object powder, the Chinese medicine composition powder obtained with the 3rd step mixes, pour into and be placed in the granulating disc of heeling condition, opening granulating disc makes it rotate, evenly spray the starch solution of vaporific 20% concentration to the mixture in granulating disc simultaneously, the weight of described starch solution is 1/5 ~ 1/10 of described mixture quality, the rotating speed of granulating disc is 50 revs/min, preparation time is 15 minutes, is prepared into the spherical particle feed that diameter is 0.8 millimeter;

3rd step, by the spherical particle feed that second step obtains, spread on the mesh-belt drier with the portable stainless steel guipure of multilayer, heat drying 10 minutes, import air temperature of heating is 150 degree, and outlet air temperature is 80 degree, obtains dry feed granules.

The described first step comprises: according to ratio of weight and number weighting raw materials material, be ground into powder after mixing; Above-mentioned steps is obtained powder to add in cold water and soak 24 hours ~ 36 hours, with slow fire boiling, decocting time is 2 hours ~ 3 hours, and decoction liquor filtered, obtain the first filtrate, the dregs of a decoction are for subsequent use, and the quality of the water added is 3 ~ 5 times of the powder quality obtained; Above-mentioned steps is filtered the filter residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each decoction 1 hour ~ 2 hours, filter and merge filtered fluid, obtaining the second filtrate, quality and the above-mentioned steps of the water added add the identical of the quality of water; First filtrate and the second filtrate are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, ensure that EAT is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, be ground into 200 order ~ 400 orders subsequently, obtain Chinese medicine composition powder.

Present invention also offers a kind of Chinese medicine composition for improving chicken immunity, described Chinese medicine composition is made up of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 10-34 part, Chinese cassia tree 10-30 part, Ligusticum wallichii 10-36 part, Amomum cardamomum 10-28 part, common spiderflower root 10-45 part, flexuose bittercress herb and seed 13-32 part, oiltea camellia seed 13-29 part, Huang 16-28 part over sixty years of age, the blue 8-45 part of thumb, mile swertia herb 13-40 part, root of herbaceous peony 13-45 part, flos caryophylli 17-40 part, fore-telling mustard 10-24 part, testis et penis canitis 14-23 part, faenum graecum 8-38 part and HERBA EPIMEDII 17-34 part.

The preparation method of described Chinese medicine composition is as follows:

The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;

Second step, the first step obtained powder and add in cold water and soak 24 hours ~ 36 hours, with slow fire boiling, decocting time is 2 hours ~ 3 hours, decoction liquor is filtered, obtain the first filtrate, the quality of the water added is 3 ~ 5 times of the powder quality that the first step obtains;

3rd step, second step is filtered the filter residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each to decoct 1 hour ~ 2 hours, filter and merge filtered fluid, obtaining the second filtrate, the quality of the water added and identical in second step;

4th step, the first filtrate and the second filtrate merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, ensure that EAT is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, be ground into 200 order ~ 400 orders subsequently, obtain Chinese medicine composition powder.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: the present invention adopts the Feed Energy containing Chinese medicine composition to overcome the various defects of Chinese medicine of the prior art and Western medicine, improve immunity and the production performance of chicken, have and have no side effect, not easily recur, without poisoning, low cost and other advantages.

Detailed description of the invention

Embodiment 1 Chinese traditional medicine composition composition powders

Embodiments provide a kind of Chinese medicine composition for improving chicken immunity, Chinese medicine additive is made up of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 21 parts, Chinese cassia tree 18 parts, Ligusticum wallichii 23 parts, Amomum cardamomum 18 parts, common spiderflower root 25 parts, flexuose bittercress herb and seed 23 parts, oiltea camellia seed 19 parts, yellow over sixty years of age 21 parts, blue 25 parts of thumb, mile swertia herb 23 parts, the root of herbaceous peony 27 parts, flos caryophylli 29 parts, fore-telling 17 parts, mustard, testis et penis canitis 19 parts, faenum graecum 24 parts and HERBA EPIMEDII 25 parts.

The preparation method of Chinese medicine additive comprises the following steps:

The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;

Second step, the first step obtained powder and add in cold water and soak 24 hours, with slow fire boiling, decocting time is 2 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 4 times of the powder quality that the first step obtains;

3rd step, second step is filtered the filter residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each to decoct 1.5 hours, filter and merge filtered fluid, obtaining the second filtrate, the quality of the water added and identical in second step;

4th step, the first filtrate and the second filtrate merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, and ensure that EAT is at 180 DEG C, leaving air temp 70 DEG C, is ground into 300 orders subsequently, obtains Chinese medicine composition powder.

Long term toxicity test

Get Adult Chicken 10, body weight is at 2.5 ~ 3kg, male and female half and half, children chicken 10, male and female half and half, body weight is at 0.5kg ~ 1kg, within 10 months, give the powder of embodiment 1 for a long time, carry out long term toxicity test, result shows all chicken general status, grows, the index such as routine blood test, Liver and kidney function is showed no abnormal change, Histopathology and gross necropsy also have no pathological change.Toxicity test proves, the not toxic effect of this medicine and bad reaction, clinical practice is safe and reliable.

Wherein, the pharmacological property of each raw medicinal material is as follows:

Radix Codonopsis: there is tonifying middle-Jiao and Qi, effect of invigorating the spleen benefit lung.Weak for the spleen deficiency syndrome of the lung, palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst.Modern study, Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, saponin and Alkaloid, has develop immunitypty, hemangiectasis, step-down, improves microcirculation, strengthens the effects such as hematopoiesis function.In addition the leucocyte caused chemotherapy radiotherapy declines and has castering action." new compilation of materia medica " is recorded: " tonifying middle-Jiao and Qi and taste, relieving thirst and restlessness.Middle gas is faint, mends in order to adjust, very smooth and proper.”

Chinese cassia tree: pungent, temperature, cure mainly: for impotence, Gong Leng, trusted subordinate's crymodynia, the cold of insufficiency type vomit and diarrhoea, through closing, dysmenorrhoea, warming meridians and promoting circulation of qi.Function cures mainly: mend fire supporing yang, let the fire back to its origin, eliminating cold to stop pain, activating blood to promote menstruation.Warming spleen and stomach, removing internal cold, promoting blood circulation.Control the Yang-function insufficiency of kidneyzang, the cold weak pulse of limb, yang depletion is collapsed, and stomachache is had loose bowels, and cold hernia is run quickly globefish, waist knee crymodynia, through closing abdominal mass, and cloudy subcutaneous ulcer, streamer, and empty sun is more floating, heat in the upper and cold in the lower.

Ligusticum wallichii: ligustrazine energy coronary artery dilator, increases coronary blood flow, improves the blood oxygen supply of cardiac muscle, and reduces the oxygen demand of cardiac muscle; The expansible cerebrovascular of ligustrazine, reduces vascular resistence, significantly increases brain and LBF amount, improves microcirculation; Can surface activity of blood platelet be reduced, suppress platelet aggregation, the formation of pre-preventing thrombosis; The neutral compound low dose of contained forulic acid promotes, heavy dose of suppression uterine smooth muscle; Water decoction has sedation to animal central nervous systems, and has obvious and lasting hypotensive effect; The absorption of fracture local hematoma can be accelerated, promote that poroma is formed; There is the effect of antivitamin E shortage; Multiple bacillus can be suppressed; There are antihistaminicum and choleretic effect.

Amomum cardamomum: taste is pungent, warm in nature, returns lung, spleen, stomach warp, effect dampness elimination, promoting the circulation of qi, Wen Zhong, preventing or arresting vomiting.Dampness elimination promoting the circulation of qi, warming middle energizer to arrest vomiting.Promoting the circulation of qi, warm stomach, helps digestion, in wide.Control the stagnation of the circulation of vital energy, eat stagnant, uncomfortable in chest, abdominal distension, gas, dysphagic, tell inverse, gastric disorder causing nausea, malaria." Kaibao Bencao ": " main long-pending cold air, antiemetic is inverse, gastric disorder causing nausea, and disappear Gu Xiaqi." bacteriostasis: the dull and stereotyped trench method of this product 100% shell decoction, has inhibitory action to shigella dysenteriae.4-terpinol contained by this product has bacteriostasis to Bacillcus thurin giensis is external.Antiasthmatic effect: the α-terpineol contained by this product, antiasthmatic effect is comparatively strong, and during to GPTSM 0.05ml/kg dosage, effect is better than Blumea oil.4-terpinol also has the antiasthmatic effect shown.The stomach invigorating of tool fragrance, wind dispelling effect, cardamom oil is very unstable, even if storage very well, is also often easily lost its peculiar fragrance, generally can be made fragrant tincture or spirit.Seed should can grind before use, has good fragrant digestion promoting function, can promote gastric secretion, excited intestinal motility, drives away pneumatosis in intestines, and suppresses abnormal fermentation in intestines.Amomum cardamomum decoction is excited to guinea pig in vitro intestinal tube low concentration; Higher than 1% and volatile oil saturated aqueous solution all in inhibitory action.Other effects: its volatile oil, to guinea pig experimental tuberculosis, can strengthen the effect of low dose of streptomysin.

Common spiderflower root: bitter; Pungent; Flat.Kidney; Urinary bladder channel.Function cures mainly: wind-expelling pain-stopping; Dampness removing is treating stranguria.Main injury and bone fracture; Urine leaching pain.

Flexuose bittercress herb and seed: sweet; Light; Cool.Function cures mainly: clearing heat and promoting diuresis; Calm the nerves; Hemostasis.Main damp-heat dysentery; Heat is drenched; Leukorrhea; Palpitaition; Insomnia; Toothache caused by fire of deficiency type; Infantile malnutrition; Spit blood; Have blood in stool; Furunculosis.

Oiltea camellia seed: bitter is flat." Luchuan book on Chinese herbal medicine ": " promoting the circulation of qi is dredged stagnant.Control qi-stagnating abdominalgia to have loose bowels." Guangzhou air force " conventional Chinese herbal medicine handbook ": " control stomachache, pruitus, burn." camellianin has antitumaous effect, the next day to Mouse oral, after local uses the carcinogen several months simultaneously, the papilloma of skin and the decreased number of cutaneum carcinoma can be made.It is invalid that camellianin local uses, and has antitumaous effect in blood containing during camellianin, and as its effect stops, then the number of cutaneum carcinoma is increased to the level similar to control group very soon.

The Radix Astragali: based on qi-restoratives, energy invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, expelling pus and promoting granulation.For insufficiency of vital energy and blood, sore caves in, purulence one-tenth is not burst or of a specified duration bursting does not hold back person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration, i.e. the abscess suppuration myogenic of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and can strengthen the immunologic function of body, therefore can also be used for the generation preventing some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five zang organs, controls arteries and veins string spontaneous perspiration, rush down yin fire, remove lung heat, lossless, sends out, has sweat then to stop." be the good medicine promoting resistance and defence disease.

Thumb is blue: Gan Xin, micro-hardship, temperature.Function cures mainly: inducing diuresis for removing edema, hot malicious wind swollen, insufficiency of the spleen fire Shengs, urine stranguria with turbid discharge, the lower blood of stool, quenches the thirst and reduces phlegm, brain leaks, nasal eczema, and aphasia from apoplexy, dyspepsia, phlegm are long-pending, evil sore.

Mile swertia herb: cold in nature, bitter.Function cures mainly: clearing heat and detoxicating, relaxing liver and strengthening stomach, anti-inflammation and sterilization.Control acute icteric hepatitis, sphagitis, tonsillitis, cystitis, urethritis, influenza, flu, malaria.

The root of herbaceous peony: the root of herbaceous peony enters liver, the spleen channel, nourishing blood and liver, pain relieving in slow, astringe yin receives sweat.Control chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, under band, married woman's blood closes obstructed, and disappear hemostasis, can lose purulence, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, brings down a fever, relieving restlessness, beneficial gas, the capable hot disease in sky, pest miasma, frightened mad, and married woman's blood is transported, and intestines wind, rushes down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, sore scabies, headache, improving eyesight, hot eyes exerts meat.The many tonifying Qi of redness of the skin or complexion person, white person controls blood.

Flos caryophylli: property is pungent, taste temperature.Enter lung, spleen, stomach, kidney four warp.Effect: Wen Zhong, warm kidney, fall inverse.Cure mainly: control hiccup, vomiting, gastric disorder causing nausea, dysentery, trusted subordinate's crymodynia, Xuan addiction, hernia, ringworm.Cloves is aromatic stomachic, can alleviate abdominal bloating, increases gastric secretion, and strengthen digestion power, alleviate n and V, water decoction has inhibitory action to staphylococcus, streptococcus, Escherichia coli, typhoid bacillus, Pseudomonas aeruginosa etc.

Foretell mustard: taste is pungent; Micro-hardship; Cold in nature.1. " the practical Chinese herbal medicine in Guangxi newly selects ": " removing toxic substances is brought down a fever, Repercusion analgesia.Control hyperpyrexia, venomous snake bite, pulmonary tuberculosis, influenza, ileotyphus, cellulitis, nameless sores or boils, malicious bee sting." 2. " Chinese herbal medicine is commonly used in Sichuan ": " detoxifies, dissipating bind.Control scrofula, furuncle sore, all carbuncles from the beginning of." 3. " register planted by Guangxi medicine ": " root-like stock: control chronic osteomyelitis, leptospirosis, burn; Leaf: control carbuncle."

Testis et penis canitis: salty temperature, enters kidney channel.Function: warming kidney to invigorate yang.Weak for kidney yang, positive certain herbaceous plants with big flowers seminal emission, woman is sombre, the diseases such as soreness of waist frequent micturition.

Faenum graecum: bitter, temperature, returns kidney channel.Function cures mainly kidney-replenishing, dispellieg cold and dampness.Control cold hernia, abdomen side of body turgor, the disturbance of lower legs due to pathogenic cold and dampness, the soreness of waist of suffering from a deficiency of the kidney, impotence.

HERBA EPIMEDII: taste is pungent; Sweet; Warm in nature.Return liver; Kidney channel.Effect: tonifying kidney and strengthening yang; Dispel rheumatism; Strong muscle key bone.Impotence and seminal emission; Empty cold sterile; Frequent micturition incontinence; Dyspnea and cough due to deficiency of the kidney; Soreness and weakness of waist and knees; Arthralgia due to wind-dampness; Hemiplegia; Four limbs are meciless.

Embodiment 2 Chinese medicine composition decoction

Embodiments provide a kind of Chinese medicine composition for improving chicken immunity, Chinese medicine additive is made up of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 17 parts, Chinese cassia tree 27 parts, Ligusticum wallichii 12 parts, Amomum cardamomum 25 parts, common spiderflower root 37 parts, flexuose bittercress herb and seed 18 parts, oiltea camellia seed 13 parts, the Radix Astragali 28 parts, blue 8 parts of thumb, mile swertia herb 36 parts, the root of herbaceous peony 42 parts, flos caryophylli 17 parts, fore-telling 24 parts, mustard, testis et penis canitis 14 parts, faenum graecum 8 parts and HERBA EPIMEDII 17 parts.

The preparation method of Chinese medicine additive comprises the following steps:

Take all raw medicinal materials according to ratio of weight and number, mixing, is ground into 150 object powder, add the water of powder 5 times of weight, at the temperature of 100 DEG C, decoct 40 minutes, decoction liquor is filtered, and obtains the first filtered fluid and filter residue, the filter residue of acquisition is added the water of 1500g, at the temperature of 100 DEG C, decoct 40 minutes, decoction liquor is filtered, and obtains the second filtered fluid, first filtered fluid and the second filtered fluid are merged, obtains decoction liquor.

Acute toxicity test

(1) experimental animal: the healthy KM mouse of SPF level, 40, male and female half and half, body weight 20-25g.

(2) reagent is detected: serum AST, ALT detection kit are purchased from Yadong, Laiyang biological products Co., Ltd.

(3) checkout equipment: Micro-200 semiautomatic biochemistry detector, assay balance, disscting instrument, syringe, test tube etc.

(4) test method:

After the adaptability of one week is raised, be divided at random 4 groups (male and female half and half), often organize each 10; Control group, 3 various dose experimental group (are respectively 76mg (crude drug)/only, 219.9mg (crude drug)/only, 357.6mg (crude drug)/only), each experimental group gavages decoction liquor prepared by embodiment 2, mouse free choice feeding, drinking-water, in feeding process, every day changes water, the next day change bedding and padding.Whole experimental period is 7 days.

(5) testing index and method

A, clinicing symptom observation: every day viewing test mouse the state of mind, diet situation, every day entry morbidity death condition.

B, pathological observation: dead mouse is carried out cuing open inspection and observes internal organ change.

C, growth indexes are observed: carry out routine weighing to test mouse; Off-test, slaughters that mouse weighs in, the heavy organ index of internal organs measures: cut open inspection kunming mice, core dirty, spleen, liver, kidney, testis, ovary, weigh, calculate organ index according to the following formula: organ index=internal organs weight/body weight × 100.

The change of d, liver function is observed: after off-test, slaughter mouse, take blood separation of serum, measures AST, ALT.

(6) data processing: above data acquisition SPSS11.0 carries out analytic statistics.

(7) clinicing symptom observation

Control group and test group mouse, the state of mind and diet wish, to external world respond have no obvious exception.The morbidity of each group of mouse and death condition as shown in table 1.

The morbidity of table 1 mouse and the death condition table of comparisons

Group	Sum	Morbidity (only)	Dead (only)	The death rate (%)
					Experimental group one	10	0	0	0
Experimental group two	10	0	0	0
					Experimental group three	10	0	0	0
Control group	10	0	0	0

Pathological observation: control group and test group, mouse carries out cuing open inspection and observes to have no and observe the obvious pathological change of internal organs after slaughtering.

Growth indexes is observed: off-test, slaughters that mouse weighs in, internal organs weight analysis is as shown in table 2.

Table 2 body weight, the internal organs weight analysis table of comparisons

Group	Liver index	Cardiac index	Renal index	Lungs index	Index and spleen index
						Experimental group one	5.45+0.12	0.71+0.06	1.34+0.05	0.69+0.04	0.43+0.02
Experimental group two	5.53+0.15	0.66+0.11	1.33+0.14	0.73+0.07	0.46+0.08
						Experimental group three	5.75+0.26	0.72+0.02	1.37+0.22	0.72+0.09	0.49+0.01
Control group	5.17+0.15	0.75+0.03	1.40+0.14	0.67+0.11	0.51+0.07

Liver function change is observed: after off-test, slaughter mouse, take blood separation of serum, measures AST, ALT as shown in table 3.

The table 3 liver function change table of comparisons

Group	Sum	ALT	AST
				Experimental group one	10	39.86+3.23	135.99+10.19
Experimental group two	10	39.76+3.13	134.67+15.41
				Experimental group three	10	39.57+1.51	136.27+16.32
Control group	10	40.12+5.23	136.29+16.52

It is not remarkable that the above results all shows each group of data difference compared with normal healthy controls group, is all in normal range (NR).

Embodiment 3 feed

Embodiments providing a kind of feed for improving chicken immunity, being made up of the raw material of following ratio of weight and number: corn 312 parts, dregs of beans 343 parts, wheat 85 parts, rice bran meal 110 parts, vitamin premix 7 parts, microelement pre-mix material 6 parts, salt 4 parts, calcium bicarbonate 7 parts, antioxidant 5 parts and Chinese medicine additive 9 parts.

Wherein, Chinese medicine additive is made up of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 21 parts, Chinese cassia tree 18 parts, Ligusticum wallichii 23 parts, Amomum cardamomum 18 parts, common spiderflower root 25 parts, flexuose bittercress herb and seed 23 parts, oiltea camellia seed 19 parts, the Radix Astragali 21 parts, blue 25 parts of thumb, mile swertia herb 23 parts, the root of herbaceous peony 27 parts, flos caryophylli 29 parts, fore-telling 17 parts, mustard, testis et penis canitis 19 parts, faenum graecum 24 parts and HERBA EPIMEDII 25 parts.

Vitamin premix is vitamin A 27900 IU/kg, vitamine D3 1880IU/kg, vitamin E 730IU/kg, Vitamin K3 5600IU/kg, vitamin B2 2400IU/kg, pantothenic acid 3600 mg/kg; Microelement pre-mix material is copper 6500mg/kg, iron 9360mg/kg, manganese 1650mg/kg, zinc 8900mg/kg, iodine 2640mg/kg, selenium 1280mg/kg, cobalt 1130mg/kg.

The embodiment of the present invention additionally provides a kind of preparation method of the feed for improving chicken immunity, comprises the following steps:

The first step, the preparation of described Chinese medicine composition additive;

Second step, feed vector is ground into 100 order ~ 200 object powder, the Chinese medicine composition powder obtained with the 3rd step mixes, pour into and be placed in the granulating disc of heeling condition, opening granulating disc makes it rotate, evenly spray the starch solution of vaporific 20% concentration to the mixture in granulating disc simultaneously, the weight of described starch solution is 1/5 ~ 1/10 of described mixture quality, the rotating speed of granulating disc is 50 revs/min, preparation time is 15 minutes, is prepared into the spherical particle feed that diameter is 0.8 millimeter;

3rd step, by the spherical particle feed that second step obtains, spread on the mesh-belt drier with the portable stainless steel guipure of multilayer, heat drying 10 minutes, import air temperature of heating is 150 degree, and outlet air temperature is 80 degree, obtains dry feed granules.

Wherein, the first step comprises: according to ratio of weight and number weighting raw materials material, be ground into powder after mixing; Above-mentioned steps is obtained powder to add in cold water and soak 24 hours ~ 36 hours, with slow fire boiling, decocting time is 2 hours ~ 3 hours, and decoction liquor filtered, obtain the first filtrate, the dregs of a decoction are for subsequent use, and the quality of the water added is 3 ~ 5 times of the powder quality obtained; Above-mentioned steps is filtered the filter residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each decoction 1 hour ~ 2 hours, filter and merge filtered fluid, obtaining the second filtrate, quality and the above-mentioned steps of the water added add the identical of the quality of water; First filtrate and the second filtrate are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, ensure that EAT is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, be ground into 200 order ~ 400 orders subsequently, obtain Chinese medicine composition powder.

Contrast test

Choose the healthy Broiler chicks 2400 of 1 age in days, be divided into three experimental group immediately, often organize 800, the feed (embodiment group 1) of the embodiment of the present invention 3, the conventional feed (embodiment group 1) being added with embodiment 2 Chinese medicine composition and the conventional feed (control group) of not adding Chinese medicine composition of the present invention is used to feed Broiler chicks respectively respectively, 1 age in days starts feeding, and experiment periods is 21 days, sub-cage rearing, free choice feeding, freely drinks water.

The mensuration of growth performance index:

Test start time and experiment terminate to weigh in units of cage respectively the empty stomach weight of experimental chicken, record total feed consumption rate, and the average daily ingestion amount of experiment with computing chicken (ADFI), average daily gain (ADG) and feed-weight ratio (F/G), and the death rate, result is as shown in Table 1 and Table 2.

The mensuration of Immune Organs Index: during 21 age in days, choose five chickens immediately from each experimental group to slaughter, complete excision spleen, thymus gland and the bursa of farbricius, remove surperficial connective tissue, to weigh the weight in wet base of thymus gland, spleen and the bursa of farbricius, calculate bursal index, index and spleen index and thymus index, be calculated as follows (result is as shown in table 3):

Bursal index=(bursa of farbricius weight/body weight) × 100%;

Index and spleen index=(spleen weight/body weight) × 100%;

Thymus index=(chest gland weight/body weight) × 100%.

Data processing: data are expressed as " average+standard deviation ", adopts SPSS17.0 statistical software to carry out one-way analysis of variance.

Results and analysis:

Table 1 is the group broiler growth performance table of comparisons respectively

Group	ADFI/g	ADG/g	F/G
				Embodiment group one	25.65+0.15	17.97+2.17	1.43+0.35
Embodiment group two	25.33+0.27	17.39+1.05	1.46+0.18
				Control group	23.36+0.25	14.22+0.92	1.64+0.07

From the data of table 1, use the chicken of the forage feed of embodiment group one and embodiment group two, its average daily ingestion amount is higher than the chicken of control group, and its average daily gain exceeds control group 3.75g and 3.17g respectively, and its feed-weight ratio is significantly lower than control group.

The average daily grazing rate of experimental group is compared with the second control group with the first control group, significantly reduces, and average daily gain is significantly higher than the first control group and the second control group, and the feed-weight ratio of experimental group and the second control group is significantly lower than the first control group.

The table 2 death condition table of comparisons

Group	Sum	Death toll	The death rate
				Embodiment group one	800	0	0
Embodiment group two	800	2	0.25%
				Control group	800	24	3%

As can be seen from Table 2, the feed adopting feed of the present invention or use to be added with Chinese medicine composition of the present invention obviously can reduce the death rate of chicken.

The table 3 Broiler chicks Immune Organs Index table of comparisons

Group	Index and spleen index	Thymus index	Bursal index
				Embodiment group 1	0.12±0.02	0.34±0.11	0.09±0.01
Embodiment group 2	0.12±0.03	0.32±0.04	0.08±0.02
				Control group	0.10±0.01	0.28±0.02	0.06±0.05

Data from table 3: compared with the broiler chicken of feeding with conventional feed, the chicken of the feed using the embodiment of the present invention 3 and the forage feed being added with the embodiment of the present invention 1 Chinese medicine composition, its index and spleen index, thymus index and bursal index slightly improve.

Known by contrast experiment, the Chinese medicine composition of the embodiment of the present invention 1 and 2 adds the feed of conventional feed and embodiment 3 as Chinese medicine additive, all can improve production performance and the survival rate of broiler chicken, improve broiler chicken index and spleen index, thymus index and bursal index, improve resistance against diseases and the immunity of broiler chicken.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (5)

1. for improving the feed of chicken immunity, it is characterized in that, described feed is made up of the raw material of following ratio of weight and number: corn 200-400 part, dregs of beans 250-433 part, wheat 50-140 part, rice bran meal 50-170 part, vitamin premix 5-9 part, microelement pre-mix material 5-8 part, salt 2-6 part, calcium bicarbonate 5-9 part, antioxidant 2-7 part and Chinese medicine additive 5-15 part;

Described Chinese medicine additive is made up of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 10-34 part, Chinese cassia tree 10-30 part, Ligusticum wallichii 10-36 part, Amomum cardamomum 10-28 part, common spiderflower root 10-45 part, wandering jew 13-32 part, oiltea camellia seed 13-29 part, Radix Astragali 16-28 part, the blue 8-45 part of thumb, mile swertia herb 13-40 part, root of herbaceous peony 13-45 part, cloves 17-40 part, fore-telling mustard 10-24 part, dog whip 14-23 part, faenum graecum 8-38 part and barrenwort 17-34 part;

The preparation method of described Chinese medicine additive comprises the following steps:

The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;

Second step, the first step obtained powder and add in cold water and soak 24 hours ~ 36 hours, with slow fire boiling, decocting time is 2 hours ~ 3 hours, decoction liquor is filtered, obtain the first filtrate, the quality of the water added is 3 ~ 5 times of the powder quality that the first step obtains;

3rd step, second step is filtered the filter residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each to decoct 1 hour ~ 2 hours, filter and merge filtered fluid, obtaining the second filtrate, the quality of the water added and identical in second step;

4th step, the first filtrate and the second filtrate merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, ensure that EAT is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, be ground into 200 order ~ 400 orders subsequently, obtain Chinese medicine composition powder;

The preparation method of described feed comprises the following steps:

The first step, the preparation of described Chinese medicine additive;

Second step, feed vector is ground into 100 order ~ 200 object powder, the Chinese medicine composition additive obtained with the first step mixes, pour into and be placed in the granulating disc of heeling condition, opening granulating disc makes it rotate, evenly spray the starch solution of vaporific 20% concentration to the mixture in granulating disc simultaneously, the weight of described starch solution is 1/5 ~ 1/10 of described mixture quality, the rotating speed of granulating disc is 50 revs/min, preparation time is 15 minutes, is prepared into the spherical particle feed that diameter is 0.8 millimeter;

3rd step, by the spherical particle feed that second step obtains, spread on the mesh-belt drier with the portable stainless steel guipure of multilayer, heat drying 10 minutes, import air temperature of heating is 150 degree, and outlet air temperature is 80 degree, obtains dry feed granules;

The described first step comprises: according to ratio of weight and number weighting raw materials material, be ground into powder after mixing; Above-mentioned steps is obtained powder to add in cold water and soak 24 hours ~ 36 hours, with slow fire boiling, decocting time is 2 hours ~ 3 hours, and decoction liquor filtered, obtain the first filtrate, the dregs of a decoction are for subsequent use, and the quality of the water added is 3 ~ 5 times of the powder quality obtained; Above-mentioned steps is filtered the filter residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each decoction 1 hour ~ 2 hours, filter and merge filtered fluid, obtaining the second filtrate, quality and the above-mentioned steps of the water added add the identical of the quality of water; First filtrate and the second filtrate are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, ensure that EAT is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, be ground into 200 order ~ 400 orders subsequently, obtain Chinese medicine additive powder.

2. the feed for improving chicken immunity according to claim 1, it is characterized in that, described Chinese medicine additive is made up of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 15-30 part, Chinese cassia tree 13-25 part, Ligusticum wallichii 16-31 part, Amomum cardamomum 14-22 part, common spiderflower root 19-35 part, wandering jew 18-27 part, oiltea camellia seed 18-21 part, Radix Astragali 19-25 part, the blue 17-32 part of thumb, mile swertia herb 19-26 part, root of herbaceous peony 21-34 part, cloves 20-38 part, fore-telling mustard 13-21 part, dog whip 17-21 part, faenum graecum 17-31 part and barrenwort 19-31 part.

3. the feed for improving chicken immunity according to claim 1 and 2, it is characterized in that, described Chinese medicine additive is made up of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 21 parts, Chinese cassia tree 18 parts, Ligusticum wallichii 23 parts, Amomum cardamomum 18 parts, common spiderflower root 25 parts, wandering jew 23 parts, oiltea camellia seed 19 parts, the Radix Astragali 21 parts, blue 25 parts of thumb, mile swertia herb 23 parts, the root of herbaceous peony 27 parts, cloves 29 parts, fore-telling 17 parts, mustard, dog whip 19 parts, faenum graecum 24 parts and barrenwort 25 parts.

4. one kind for improving the Chinese medicine composition of chicken immunity, it is characterized in that, described Chinese medicine composition is made up of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 10-34 part, Chinese cassia tree 10-30 part, Ligusticum wallichii 10-36 part, Amomum cardamomum 10-28 part, common spiderflower root 10-45 part, wandering jew 13-32 part, oiltea camellia seed 13-29 part, Radix Astragali 16-28 part, the blue 8-45 part of thumb, mile swertia herb 13-40 part, root of herbaceous peony 13-45 part, cloves 17-40 part, fore-telling mustard 10-24 part, dog whip 14-23 part, faenum graecum 8-38 part and barrenwort 17-34 part.

5. the Chinese medicine composition for improving chicken immunity according to claim 4, is characterized in that, the preparation method of described Chinese medicine composition is as follows:

The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;

Second step, the first step obtained powder and add in cold water and soak 24 hours ~ 36 hours, with slow fire boiling, decocting time is 2 hours ~ 3 hours, decoction liquor is filtered, obtain the first filtrate, the quality of the water added is 3 ~ 5 times of the powder quality that the first step obtains;

3rd step, second step is filtered the filter residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each to decoct 1 hour ~ 2 hours, filter and merge filtered fluid, obtaining the second filtrate, the quality of the water added and identical in second step;

4th step, the first filtrate and the second filtrate merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, ensure that EAT is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, be ground into 200 order ~ 400 orders subsequently, obtain Chinese medicine composition powder.