CN102657794B - Traditional Chinese medicine for prevention and treatment of pullorum disease, preparation method thereof and feed - Google Patents
Traditional Chinese medicine for prevention and treatment of pullorum disease, preparation method thereof and feed Download PDFInfo
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Abstract
The invention provides traditional Chinese medicine for prevention and treatment of pullorum diseases, which comprises coptis chinensis, radix sophorae flavescentis, pulsatilla chinensis, rhizoma anemarrhenae, selfheal, honeysuckle, radix scrophulariae, codonopsis pilosula, rhizoma atractylodis macrocephalae, lotus seeds, dark plum, granatum and semen coicis. The traditional Chinese medicine has the advantages of high efficacy, fewer toxic and side effects, no residues, no resistance to drugs, no environmental pollution, capability of improving the body resistance, short treatment course, rapid effects and wide scope of promotion and application in prevention and treatment of chicken suffering from pullorum diseases.
Description
Technical field
The present invention relates to the herbal medicine technical field, relate in particular to a kind of Chinese medicine for prevention and treatment white diarrhea.
Background technology
White diarrhea is the large and multiple communicable disease of poultry husbandry harmfulness always, and generation is all arranged all over the world, the highest with the chick M & M in 10 monthly ages, therefore, once within quite long period, is considered to only have just infection morbidity of chick.In later stage 1980's, people have had new understanding to the occurrence regularity of white diarrhea, and this disease is the chick susceptible not only, and the young chicken of 50～120 ages in days also often has and breaks out.The harm of this disease can run through the whole growth course of chicken, and fatal rate, up to 50%～60%, is to endanger one of maximum infectious disease in aviculture.
The cause of disease of white diarrhea is white diarrhea salmonella (S. Pullorum) (being called for short the dysentery characterized by white mucous stool bacterium, lower same).Salmonella (Sallonella) pathogen, belong to enterobacteriaceae, and Salmonella, be large numbers of similar gram-Negative bacilluses of form, cultural character, reaction and antigenic structure in the humans and animals enteron aisle that parasitize.Salmonellosis is a kind of common important infecting both domestic animals and human intestines problem, is one of zoonosis significant on public hygienics, comprises and causes food poisoning, causes the bacterium of gastroenteritis, Typhoid and paratyphoid.White diarrhea salmonella form is the slightly elongated bacillus (0.3～0.5 μ m * 1～1.25 μ m) of circle of two ends, Gram-positive, do not move, without pod membrane, do not form gemma, amphimicrobian, cold-resistant thermo-labile in external environment, dead immediately in boiling water, but boil 5min in the egg domestic demand, can kill, general disinfectant can kill it at short notice.This bacterium is infected chicken and turkey only, and in liver, lung, intestines, yolk bag, the heart and the blood of sick chicken, bacteria containing amount is the highest.
The pathogenesis of white diarrhea disease is still not fully aware of at present.It is generally acknowledged that the dysentery characterized by white mucous stool bacterium enters body, by macrophage phagocytic, at the intestines wall, settle down, breed, the destroyed endotoxin that discharges of thalline in macrophage.When the animal body resistance is strong, the dysentery characterized by white mucous stool bacterium was eliminated through 1～5 day in intestines., Abwehrkraft des Koepers suitable once environment weakens, and the dysentery characterized by white mucous stool bacterium is distributed to each histoorgan with blood circulation, thereby forms corresponding pathological change and clinical symptoms.
The common method of prevention at present and treatment white diarrhea disease is to rely on the Western medicine controls such as antibiotic and sulfamido, although obtained certain curative effect, but extensive use and unreasonable use along with antibacterials, caused the Salmonella gallinarum drug resistance to increase year by year, not only cause that pathogen produces drug resistance, also can cause that conditionity pathogenic bacteria and parachorium bacterium produce drug resistance, and drug resistance can pass to the crowd by food chain, also endanger human health.Therefore, seek to prevent and treat good effect and the non-harmful medicament-resistant inhibitor of salmonellosis of chicken, obtain safe poultry prod and more and more come into one's own.
Chinese medicine is the distinctive natural resources of China, infect, reverse the aspect such as (or inhibition) tumor cell drug resistance in treatment and shown unique effect, this points out us can in Chinese medicine, find the medicine that existing good drug-resistant eradicating efficacy does not have again toxic and side effect or the lower prevention of toxic and side effect and treats white diarrhea disease.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of novel Chinese medicine for prevention and treatment white diarrhea and preparation method thereof, adopt this Chinese medicine to the white diarrhea prevention and treatment has efficiently, toxic and side effect is little, noresidue, do not develop immunity to drugs, free from environmental pollution, can increase Abwehrkraft des Koepers, short treating period, effect rapid, cheap, have and the advantage such as apply.
In order to solve above-mentioned technology, ask, the invention provides the Chinese medicine of a kind of prevention and treatment white diarrhea, it comprises: the coptis, kuh-seng, the Chinese bulbul, the wind-weed, selfheal, honeysuckle, radix scrophulariae, Radix Codonopsis, the bighead atractylodes rhizome, lotus seeds, dark plum, granatum, coix seed.
Wherein, the ratio of weight and number of each component in described Chinese medicine is, the coptis 33～39 weight portions, kuh-seng 13～19 weight portions, the Chinese bulbul 42～49 weight portions, the wind-weed 36～42 weight portions, selfheal 17～21 weight portions, honeysuckle 23～30 weight portions, radix scrophulariae 12～18 weight portions, Radix Codonopsis 25～32 weight portions, the bighead atractylodes rhizome 20～26 weight portions, lotus seeds 15～22 weight portions, dark plum 13～18 weight portions, granatum 10～16 weight portions, coix seed 9～14 weight portions.
Wherein, the ratio of weight and number of each component in described Chinese medicine is, the coptis 36～39 weight portions, kuh-seng 16～19 weight portions, the Chinese bulbul 46～49 weight portions, the wind-weed 39～42 weight portions, selfheal 19～21 weight portions, honeysuckle 26～30 weight portions, radix scrophulariae 15～18 weight portions, Radix Codonopsis 28～32 weight portions, the bighead atractylodes rhizome 23～26 weight portions, lotus seeds 19～22 weight portions, dark plum 15～18 weight portions, granatum 13～16 weight portions, coix seed 12～14 weight portions.
Wherein, described Chinese medicine can also comprise hawthorn and the membrane of a chicken's gizzard, and described hawthorn and the membrane of a chicken's gizzard ratio of weight and number in described Chinese medicine is, hawthorn 3～6 weight portions, the membrane of a chicken's gizzard 2～4 weight portions.
Wherein, described Chinese medicine can also comprise Nuzhen, an ancient nationality in China, ancestors of the Manchus, who founded the Jin Dynasty's and eclipta, and described Nuzhen, an ancient nationality in China, ancestors of the Manchus, who founded the Jin Dynasty and the ratio of weight and number of eclipta in described Chinese medicine be, Nuzhen, an ancient nationality in China, ancestors of the Manchus, who founded the Jin Dynasty's 6～10 weight portions, eclipta 7～12 weight portions.
Ask in order to solve above-mentioned technology, the invention provides the preparation method of above-mentioned Chinese medicine, when the formulation of described Chinese medicine is decoction, comprise,
The first step, mix described component in proportion, pulverizes;
Second step, add the water with respect to 2～4 times of described mixture qualities in the mixture after pulverizing, decoct 2～4 hours, filter, in filter residue, add the water with respect to 1～2 times, described mixture again to decoct 1～2 hour, filter, twice filtrate is mixed, being evaporated to crude drug concentration is 1g/ml～3g/ml.
Ask in order to solve above-mentioned technology, the invention provides the preparation method of above-mentioned Chinese medicine, when the formulation of described Chinese medicine is powder, comprise,
The first step, drop in proportion mixer by described component and stir 30～50 minutes, fully mixes, and pulverizes;
Second step, add the water with respect to 2～4 times of described mixture qualities in the mixture after pulverizing, decoct 2～4 hours, filter, in filter residue, add the water with respect to 1～2 times, described mixture again to decoct 1～2 hour, filter, twice filtrate is mixed, and reduced pressure concentration is removed moisture, obtains dry lotion, further and pulverizing dry with spray dryer, sieve and obtain 50～100 order traditional Chinese powder medicine fine powders.
In order to solve above-mentioned technology, ask, the invention provides a kind of feed, it comprises feed addictive and feed vector, and described feed addictive comprises that above-mentioned Chinese medicine is as additive.
Wherein, with respect to the feed addictive of 100 weight portions, the addition of described Chinese medicine additive can be 30～70 weight portions.
Wherein, can also comprise acidulant in described feed addictive, feed addictive with respect to 100 weight portions, the addition of described acidulant can be 10～30 weight portions, described acidulant comprises one or more mixing in Pfansteihl, fumaric acid, citric acid, and when described acidulant is the mixture of above-mentioned several materials, the weight fraction of each component is than being Pfansteihl 25～35 weight portions, fumaric acid 15～30 weight portions, citric acid 20～30 weight portions.
Beneficial effect of the present invention:
With respect to the medicine for prevention and treatment white diarrhea of the prior art, adopt this Chinese medicine composition to prevention and the treatment of the chicken that suffers from white diarrhea have efficiently, toxic and side effect is little, noresidue, do not develop immunity to drugs, free from environmental pollution, can increase Abwehrkraft des Koepers, short treating period, effect rapid, cheap, have and the advantage such as apply.
The specific embodiment
The white diarrhea infection sources is extensive, the circulation way complexity, but brief overview is vertical transmission and two kinds of modes of horizontal transmission.After the egg that carries disease germs enters to incubate, in egg, the dysentery characterized by white mucous stool bacterium breeds rapidly, causes the part embryonic death, and the chick after hatching becomes the young bird that carries disease germs, and the survival chicken is the chicken that carries disease germs.Its manure contamination environment and water, material, apparatus etc., scatter cause of disease, infects other healthy chicken, becomes the horizontal transmission source; On the other hand by the mating of carrying disease germs, then produce the egg that carries disease germs and be incorporated to and incubate.So move in circles, go round and begin again, pass on from generation to generation, form multipath and propagate chain.
The clinical symptoms of chick white diarrhea are mainly the weak young birds that stillborn foetus occurs in hatching process, can not go out shell, at brooder, see that weak young bird all belongs in egg and infecting.Sick young weak in appetite, die by visitation of God can occur.Sometimes after going out shell, 5～10 talentes see the dysentery characterized by white mucous stool case, in subsequently 7～10 days, day by day increase the weight of, and usually at the 2nd, the 3rd week, reach peak mortality, and its pathological change is mainly, and prominent dead chick hepatomegaly, have striped hyperemia.Also have other organs hyperemia at septic, yolk bag absorbs bad (content is yellowy butyrous or cheesy).The course of disease is grown, and the heart, liver, lung, caecum, large intestine and muscular stomach have Necrotic Nodule, and liver also has petechial hemorrhage.The nephremia or anaemia, ureter is expanded because being full of lithate.Caecum has cheesy thing, sometimes is mixed with blood.Young hemorrhagic pneumonia in 10 ages in days, more older have a liver pathological changes district.Nodosity in cardiac muscle.
Manifest symptom does not occur for propagating for a long time after infecting in the clinical symptoms of Adult Chicken white diarrhea, but laying rate, rate of fertilization, incubation rate descend.Middle chicken and incubation chicken performance cockscomb atrophy anaemia, wing descends, and neck is rolled up diarrhea, eats less or does not eat the course of disease 4～5 days, short person death in 1 day.The pathological change of Adult Chicken is mainly the ovum distortion, and variable color is cryptomere, peritonitis, acute or chronic pericarditis.The ovum of being injured contains grease or cheese thing and is attached on ovary at the coating of thick layer.The common pericarditis of male and female chicken, the lighter's pericardium is transparent poor, and pericardial fluid increases, has the folliculus bag of amber caseous substance, or is embedded in abdominal cavity fat, or invests on stomach or intestines wall.
Chinese veterinarian thinks, white diarrhea is that qi and blood does not fill because the chicken internal organs are tender and lovely, and spleen sun element is empty, wet by interior life; Positive unsaturated vapor, weakened defensive QI, susceptible cold-evil, empty, wet, cold three heresies mingle and cause a disease, therefore treat should take clearing heat and detoxicating, relieving diarrhea with astringents, replenish qi to invigorate the spleen as principle.
Based on mentioned above principle, Chinese medicine composition of the present invention comprises: the coptis, kuh-seng, the Chinese bulbul, the wind-weed, selfheal, honeysuckle, radix scrophulariae, Radix Codonopsis, the bighead atractylodes rhizome, lotus seeds, dark plum, granatum, coix seed.
The mechanism of Chinese herb prevention white diarrhea is: the specificity and the nospecific immunity that strengthen body comprise the generation that increases antibody and complement, increase the generation of cell factor; Suppress virus breeding (suppressing the expression of body inner virus mRNA); Remove harmful free radical; Antibiotic, elimination complication; Protect the liver and protect kidney, thereby guarantee normal physiological function and the resistance against diseases of eliminating paathogenic factor.
Each component pharmacology is as follows:
The coptis: bitter, cold in nature, enter the heart, lung, courage, stomach, large intestine channel, heat-clearing and damp-drying drug is arranged, purging intense heat and detonicating, the effect of cooling blood for improving eyesight, cure mainly damp and hot ruffian full, the vomiting acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head is told nosebleed, hot eyes, toothache, quench one's thirst, the carbuncle furunculosis that swells, eczema, wet sore, the duct card such as suppurate, the coptis is light broad spectrum antiviral drug thing, can effectively reduce the drug resistance of salmonella, to staphylococcus aureus, blood dissolubility streptococcus, streptococcus pneumonia, meningococcus, shigella dysenteriaes etc. have stronger bacteriostasis, amplification on Canon of Materia Medica: the multiplex dysentery of controlling of moderns, lid is held the justice dry with hardship.Lower valgar but see that intestines void is oozed and let out, micro-seemingly have a bloody stool, uses it, only more do not know.Ignore again fever and chills how many, but take most agent as degree, by being that to cause danger tired more.If gas is real just sick, hot many bloody flux, just stopping of clothes still needn't be use up agent also.Or empty and cold, must not take.Remaining as " warp ".
Kuh-seng: bitter, cold in nature, return liver, kidney, large intestine, small intestinl channel, bladder, the heart channel of Hang-Shaoyin, have the effect of heat-clearing and damp-drying drug, wind dispelling insecticide, while curing mainly, heat is gone mad, hot malicious accumulation of pathogens in chest, quench one's thirst, damp-heat dysentery, hematochezia, the lower pruritus vulvae of band, jaundice, hot urination, the rubella itch, mange, leprosy, the cards such as eczema of lower limb ulcer, kuh-seng all has obvious inhibitory action to shigella dysenteriae, Escherichia coli, proteus, beta streptococcus and staphylococcus aureus.
The Chinese bulbul: bitter, cold in nature, enter stomach, large intestine channel, have clearing heat and detoxicating, the effect of removing heat from the blood and relieve diarrhea, being mainly used in stomach and intestine has damp and hot stagnant heating stomachache, diarrhea purulence blood, tenesmus card such as grade; To blood better effects if under the hot dysentery of large intestine blood-head, shigella dysenteriae, typhoid bacillus, hay bacillus, Escherichia coli, gold look staphylococcus, Sharpe door bacterium are had to stronger inhibitory action.
The wind-weed: bitter, sweet, cold in nature, enter lung, stomach, kidney channel, the relieving restlessness of purging heat is arranged, the effect of nourshing Yin and drynsessmoistening prescription, removing heat from the lung to relieve cough, cure mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior heat symptom such as quench one's thirst; Its bitter cold matter profit, the property sedimentation, can heat-clearing, can promote the production of body fluid again, kindly controls warm disease and evil and enters gas and divide, and heat is contained and is hindered Tianjin; Also be used for the treatment of diabetes; Phlegm-heat obstructing lung and breathing heavily, the xeropulmonary cough, phlegm is few unfavorable; Fire excess from yin deficiency, the symptoms such as flaring up of deficient fire, the wind-weed has inhibitory action to various bacteria such as shigella dysenteriae, typhoid bacillus, Escherichia coli, proteus, staphylococcus, streptococcus.
Selfheal: cold in nature, bitter, suffering, return liver, gallbladder channel, have clear liver and improve vision, the effect of powder detoxifcation, for red eye, swell pain, order pearl nyctalgia, have a headache dizzy, scrofula, goiter and tumor, swell and ache; The thyroid gland enlargement, scrofula, the proliferation of mammary gland, the card such as hypertension, hyperglycaemia, high fat of blood and high blood are sticky, have obvious inhibitory action to shigella dysenteriae, cholera bacilli, typhoid bacillus, Escherichia coli, proteus, staphylococcus.
Honeysuckle: distinguish the flavor of sweet, cold in nature, enter the heart, lung, stomach, large intestine channel, clearing heat and detoxicating effect is arranged, double can removing heat from the blood and relieve diarrhea, be mainly used in affection of exogenous wind-heat, the hot poison of warm heat disease is contained, or warm disease is from the beginning of heat evil still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; The malicious diarrhea of heat, the lower blood of stool; Heat temperature card; The sore carbuncle that hot poison gathers is from the beginning of the ， inflammation heat person of swelling and ache, and other skin infections, and this thing has antipyretic effect preferably, and antiinflammatory action is arranged, and can promote leukocytic phagocytic function, and multiple pyococcus and pathogenic entero becteria are had to stronger bacteriostasis.
Radix scrophulariae: bitter, sweet, salty, cold nature, enter lung, stomach, kidney channel, has the effect of clearing heat and cooling blood, nourishing Yin and falling fire, detoxicating and resolving a mass, for warm heat disease heat enter ying blood, vigorous heat at qi-blood phase, send out the spot dermexanthesis; Constipation is hindered in consumption of YIN caused by febrile disease, Tianjin, hectic fever due to yin labor is coughed; Hot eyes is red and swollen, have sore throat, the treatment of the card such as too fat to move sore, and radix scrophulariae has obvious inhibitory action to staphylococcus aureus, corynebacterium diphtheriae, typhoid bacillus, Pseudomonas aeruginosa, beta streptococcus, Escherichia coli, shigella flexneri.
Radix Codonopsis: distinguish the flavor of sweet, property is flat, enters lung, the spleen channel, and tonifying Qi benefit spleen is arranged, the effect of nourishing blood to promote the production of body fluid, be mainly used in spleen-lung Qi deficiency or qi-blood deficiency lassitude hypodynamia, breathe hard, the symptoms such as cough spontaneous perspiration, and Radix Codonopsis is longer than the tonifying spleen nourishing the stomach, adjust regulating the function of middle-JIAO, have the effect of nourishing blood concurrently, its property is flat, invigorating the spleen fortune and not dry; Flavour is cloudy and not wet, can improve the immune state of body, improves resistance against diseases, promotion is digested and assimilated, improve metabolism, promote the absorption of enteron aisle to nutriment, Radix Codonopsis is inhibited to meningococcus, corynebacterium diphtheriae, catalin diplococcus, paracolon and Escherichia coli.
The bighead atractylodes rhizome: bitter, sweet, warm in nature, enter spleen, stomach warp, there is strengthening the spleen and replenishing qi, eliminating dampness Li Shui, strengthening exterior and reducing sweat, antiabortive effect, for weakness of the spleen and the stomach, the few turgor of food, lassitude hypodynamia, have loose bowels, water-damp retention, phlegm and retained fluid, oedema, the cards such as exterior deficiency spontaneous perspiration, the bighead atractylodes rhizome has to be adjusted gastrointestinal motility function, antiulcer, protects the liver, the enhanced machine body immunity function, anti-ly stress, strengthen the effect such as hematopoiesis function; Its eliminating dampness profit water effect is relevant with diuresis; And antiabortive effect is relevant with the effect of inhibition uterine contractile, that the bighead atractylodes rhizome has is anti-oxidant, delay senility, hypoglycemic, anticoagulation, the effect such as antitumor, can improve the immunologic function of body, increase quantity of leucocyte, inhibited to staphylococcus aureus, hemolytic streptococcus, diplococcus meningitidis, hay bacillus etc.
Lotus seeds: distinguish the flavor of sweet, puckery, property is flat, returns spleen, kidney, the heart channel of Hang-Shaoyin, has the effect of tonifying spleen antidiarrheal, supplementing the kidney to control the nocturnal, mental-tranquilization, and for weakness of the spleen and the stomach, food is few weak, and vomiting is had loose bowels, suffer from a deficiency of the kidney not solid, and emission and spermatorrhea, the nocturnal emission turbid urine, have no peace of mind, cardiac muscle, the cards such as insomnia.
Dark plum: bitter, acid, puckery, warm in nature, return liver, lung, spleen, large intestine channel, have and astringe the lung, puckery intestines, hemostasis, the effect of promoting the production of body fluid, be used for the treatment of protracted dysentery more than, damp-heat dysentery, have blood in stool, the card such as hematuria, snowslide, inhibited to multiple germs such as shigella dysenteriae, Escherichia coli, typhoid bacilluses.
Granatum: flavor acid, puckery, warm in nature, return large intestine, kidney channel, there is relieving diarrhea with astringents, hemostasis, the effect of desinsection, for rushing down protracted dysentery for a long time, hematochezia, under the uterine bleeding band, the cards such as abdominal pain due to enterositosis, granatum is inhibited to multiple germs such as staphylococcus aureus, shigella dysenteriae, Escherichia coli, typhoid bacilluses.
Coix seed: distinguish the flavor of sweet, light, cold nature, return lung, spleen, large intestine channel, and invigorating the spleen to arrest diarrhea is arranged, and Li Shui is except numbness, and the effect of row's sore purulence, be mainly used in having loose bowels of wet tired lung stomach; Damp evil is invaded the anasarca of stain skin, difficult urination; The damp and hot resistance in the numbness of qi and blood passes to and the scorchingly hot cards such as lung carbuncle in the lung intestines, acute appendicitis that pent up.
Further preferably, the described Chinese medicine composition that is used for the treatment of white diarrhea only consists of said components.
During Chinese medicine of the present invention has bacteriogenic endotoxin and exotoxin and destruction, can strengthen the defense function of body, strengthen the phagocytosis of cell, promote the effects such as lymphocytic conversion ratio, thereby improve the resistance infection of body, contribute to improve digestive function simultaneously, promote appetite, build up health.
In the described Chinese medicine composition that is used for the treatment of white diarrhea, the ratio of weight and number of various components can be preferably:
The coptis 33～39 weight portions, kuh-seng 13～19 weight portions, the Chinese bulbul 42～49 weight portions, the wind-weed 36～42 weight portions, selfheal 17～21 weight portions, honeysuckle 23～30 weight portions, radix scrophulariae 12～18 weight portions, Radix Codonopsis 25～32 weight portions, the bighead atractylodes rhizome 20～26 weight portions, lotus seeds 15～22 weight portions, dark plum 13～18 weight portions, granatum 10～16 weight portions, coix seed 9～14 weight portions.
In the described Chinese medicine composition that is used for the treatment of the animal white diarrhea, the ratio of weight and number of various components also can be more preferably: the coptis 36～39 weight portions, kuh-seng 16～19 weight portions, the Chinese bulbul 46～49 weight portions, the wind-weed 39～42 weight portions, selfheal 19～21 weight portions, honeysuckle 26～30 weight portions, radix scrophulariae 15～18 weight portions, Radix Codonopsis 28～32 weight portions, the bighead atractylodes rhizome 23～26 weight portions, lotus seeds 19～22 weight portions, dark plum 15～18 weight portions, granatum 13～16 weight portions, coix seed 12～14 weight portions.
Eliminate eating accumulation for promoting ill chicken, promotion is digested and assimilated, the described Chinese medicine composition for prevention and treatment white diarrhea can also comprise hawthorn and the membrane of a chicken's gizzard, described hawthorn and the membrane of a chicken's gizzard ratio of weight and number in described Chinese medicine composition is, hawthorn 3～6 weight portions, the membrane of a chicken's gizzard 2～4 weight portions.
Hawthorn: flavor acid, sweet, slightly warm in nature, enter spleen, stomach, Liver Channel, and for food digesting stomach fortifying, the promoting the circulation of qi stasis of blood of fall apart, be mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, have loose bowels, dysentery, hawthorn is the staple for the treatment of indigestion, hawthorn can increase the secretion of peptic digest enzyme, promotes to digest; Shigella dysenteriae, Pseudomonas aeruginosa, staphylococcus aureus etc. are had to obvious inhibitory action.
The membrane of a chicken's gizzard: distinguish the flavor of sweet, cold in nature, enter spleen, stomach, small intestine, urinary bladder channel, there are reinforcing spleen to promote digestion, puckery essence to stop excessive effect, are mainly used in the abdominal fullness and distention of dyspepsia stagnation, heating installation diarrhoea, the symptoms such as children's's infantile malnutrition due to digestive disturbances or intestinalparasites disease, the membrane of a chicken's gizzard can promote the effects such as gastric secretion, enhancing peristole, acceleration gastric emptying.
By adding these two kinds of auxiliary elements of upper hawthorn and Divine Comedy, can eliminate eating accumulation and advance digestion, increase enterogastric peristalsis, in case abdominal fullness and distention, food is few, dysentery, have and regulate the flow of vital energy, and stomach, the effect of invigorating the spleen, make ill chicken feed want to increase, improve resistance against diseases and immunologic function, reduce the incidence of disease, play a role in health care, thus prevention and treatment white diarrhea.
The described Chinese medicine composition for prevention and treatment white diarrhea can also comprise Nuzhen, an ancient nationality in China, ancestors of the Manchus, who founded the Jin Dynasty's and eclipta, and described Nuzhen, an ancient nationality in China, ancestors of the Manchus, who founded the Jin Dynasty and the ratio of weight and number of eclipta in described Chinese medicine composition be, Nuzhen, an ancient nationality in China, ancestors of the Manchus, who founded the Jin Dynasty's 6～10 weight portions, eclipta 7～12 weight portions.
The fruit of glossy privet: distinguish the flavor of sweet, bitter, be slightly cold, enter liver, kidney channel, strong liver kidney-nourishing is arranged, the effect of removing heat to brighten vision, be mainly used in treating liver-kidney Yin deficiency, and the head loses foster dizzy tinnitus, the symptoms such as yin asthenia generating intrinsic heat.The fruit of glossy privet can promote leucocyte, strengthens the effect of immunologic function, and staphylococcus aureus, shigella dysenteriae are had to stronger inhibitory action.
Eclipta: distinguish the flavor of sweet, sour, cold in nature, return liver, kidney channel, play not liver and kidney benefiting, the effect of cooling blood and hemostasis, for having a dizzy spell due to the deficiency of liver-yin and kidney-yin, blurring of vision, soreness and weakness of waist and knees; Be suitable for the deficiency of Yin hot person is arranged, be used for the treatment of the haematemesis of accumulated heat in stomach, the symptoms such as the hemoptysis of heat impairing pulmonary collateral, eclipta has inhibitory action to staphylococcus aureus, typhoid bacillus, Song's Shigella flexneri, Pseudomonas aeruginosa, can obviously strengthen nospecific immunity and cellular immune function.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition decoction, and it comprises:
The first step, mix described component in proportion, pulverizes;
Second step, add the water with respect to 2～4 times of described mixture qualities in the mixture after pulverizing, decoct 2～4 hours, filter, in filter residue, add the water with respect to 1～2 times, described mixture again to decoct 1～2 hour, filter, twice filtrate is mixed, being evaporated to crude drug concentration is 1g/ml～3g/ml.
The present invention also provides the preparation method of above-mentioned Chinese traditional medicine composition composition powders, and it comprises:
The first step, drop in proportion mixer by described component and stir 30～50 minutes, fully mixes, and pulverizes;
Second step, add the water with respect to 2～4 times of described mixture qualities in the mixture after pulverizing, decoct 2～4 hours, filter, in filter residue, add the water with respect to 1～2 times, described mixture again to decoct 1～2 hour, filter, twice filtrate is mixed, and reduced pressure concentration is removed moisture, obtains dry lotion, further and pulverizing dry with spray dryer, sieve and obtain 50～100 order Chinese traditional medicine composition composition powders fine powders.
The present invention also provides a kind of using method of above-mentioned Chinese medicine composition, and it comprises: by described Chinese traditional medicine composition composition powders and feed vector phase mix and blend, subsequently by the ill chicken of mixture feeding of this stirring.
The present invention also provides the another kind of using method of above-mentioned Chinese medicine composition, and it comprises: by the ill chicken of described decoction gavage, each 1 dose, 4～6 doses of every days.
The present invention also provides a kind of fodder compound, comprises feed addictive and feed vector in said composition, and described feed addictive comprises above-mentioned Chinese medicine composition additive.
Described feed vector is preferably one or more in corn, wheat, soybean, wheat bran, Chinese sorghum etc.
When described feed vector is mixture, described wheat bran 20 ~ 40 weight portions, described corn 5 ~ 10 weight portions, described wheat 5 ~ 10 weight portions, described soybean 10 ~ 20 weight portions, described Chinese sorghum 15 ~ 25 weight portions.
With respect to the feed vector of 100 weight portions, the addition of described feed addictive can be 8～12 weight portions.
With respect to the feed addictive of 100 weight portions, the addition of described Chinese medicine composition additive can be 30～70 weight portions, more preferably 50～60 weight portions.
Can also comprise acidulant in described feed addictive, by adding the acidulant can sterilization and anticorrosion, regulate and control GI colony balance, be conducive to the breeding growth of the beneficial bacteriums such as Bacillus acidi lactici, suppress the quantity of the harmful bacterias such as Escherichia coli, improve the animal anti-stress effect, improve animal immunizing power, and can participate in internal metabolism directly, release energy, promote the absorption of mineral matter, vitamin and nutriment.
With respect to the feed addictive of 100 weight portions, the addition of described acidulant can be 10～30 weight portions, more preferably 20～30 weight portions.
Described acidulant comprises one or more mixing in Pfansteihl, fumaric acid, citric acid.
When described acidulant is the mixture of above-mentioned several materials, the weight fraction of each component is than being Pfansteihl 25～35 weight portions, fumaric acid 15～30 weight portions, citric acid 20～30 weight portions.
Can also comprise the nutritional labeling supplemented by additives in described feed addictive, with respect to the feed addictive of 100 weight portions, the addition of described nutritional labeling supplemented by additives can be 10～30 weight portions, more preferably 20～30 weight portions.
Described nutritional labeling supplemented by additives can comprise one or more mixing in lysine, methionine, wood sugar alcoholase, hemicellulase, and the weight fraction of each component ratio is, lysine 10～20 weight portions, methionine 10～20 weight portions, wood sugar alcoholase 10～20 weight portions, hemicellulase 10～20 weight portions.
Also further add feed adhesive in described fodder compound, with respect to 100 weight portion feed vectors, the addition of described feed adhesive can be 10～20 weight portions.
Described feed adhesive may further include: one or more in Strong flour, starch, ammonium sulfate and sodium acid carbonate; Wherein, the weight fraction of various compositions ratio is, Strong flour is 60 ~ 80 parts, and starch is 30 ~ 50 parts; Ammonium sulfate and sodium acid carbonate add up to 3 ~ 8 parts; Described starch is preferably as cornstarch, and wherein farinose ratio of weight and number is 70 ~ 90 parts, and the ratio of weight and number of ripe starch is 10 ~ 20 parts; Described Strong flour is the flour that the protein wt degree is greater than 15%.
The present invention also provides the preparation method of above-mentioned fodder compound, and it comprises:
The first step, prepare the described Chinese traditional medicine composition composition powders as additive as stated above, dry rear standby;
Second step, mix Pfansteihl, fumaric acid, citric acid in described ratio, add the water mixing and stirring with respect to 1 ~ 2 times of mixture quality, and send into the spraying granulation tower and carry out spraying granulation, the particle drying made, and sieve, obtain 60 orders ~ 80 purpose acidulants;
The 3rd step, each component of getting in feed adhesive is mixed, and adds water to start modified, refining temperature is 62 ~ 68 ℃, the rear dry feed adhesive that obtains that stirs, with respect to the weight of each component in the feed adhesive of 100 weight portions and, the addition of described water is 15 ~ 30 weight portions;
The 4th step, by described corn, wheat, barley, soybean and wheat bran, one or more are pulverized after mixing, and grinding particle size is 300～550 mm, makes its fine powder amount reach more than 92% of total material, obtains feed vector;
The 5th step, the Chinese traditional medicine composition composition powders that the first step is obtained, the acidulant that second step obtains, the feed adhesive that the 3rd step obtains, the feed vector that the 4th step obtains mixes, putting into multiplex mixer stirs 120 minutes～150 minutes, put into the ring mode bulking machine after taking-up expanded, control the temperature of bulking machine between 80 ℃～90 ℃, the expanded time is 1～2 hour, the aridity of controlling material to be extruded is 90%～95%, proceed to after taking-up in ring mode grit machine and be produced into precipitation hard particles feed, then use 50 orders ~ 100 meshes to sieve, obtain described fodder compound.
In the preparation method of described fodder compound, the 4th step can also further add the nutritional labeling supplemented by additives.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how the application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
The toxicity test of embodiment 1 Chinese medicine composition of the present invention
The 39g coptis, 19g kuh-seng, the 49g Chinese bulbul, the 42g wind-weed, 21g selfheal, 30g honeysuckle, 18g radix scrophulariae, 32g Radix Codonopsis, the 26g bighead atractylodes rhizome, 22g lotus seeds, 18g dark plum, 16g granatum, 14g coix seed are mixed, pulverize; Water to adding 1000g in the mixture after pulverizing, decoct 3 hours, filters, and in filter residue, adds the water of 400g again to decoct 2 hours, filters, and twice filtrate is mixed, and is evaporated to the decoction that crude drug concentration is 3g/ml.
Get the ICR mouse, body weight, at 25～30 grams, is pressed the body weight random packet, and 10 every group, male and female half and half, the oral administration solution administration, dosage only is 5.8ml/.After administration, Continuous Observation is 20 days, and all mouse of result are strong deposits, and its activity, diet, hair, excreta are no abnormal, have no toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, there are no irritative response and other bad reaction.
Toxicity test proves, the not toxic effect of this medicine and bad reaction, and clinical practice is safe and reliable.
The preparation of embodiment 2 Chinese medicine composition decoctions
The 390g coptis, 190g kuh-seng, the 490g Chinese bulbul, the 420g wind-weed, 210g selfheal, 300g honeysuckle, 180g radix scrophulariae, 320g Radix Codonopsis, the 260g bighead atractylodes rhizome, 220g lotus seeds, 180g dark plum, 160g granatum, 140g coix seed are mixed, pulverize; Water to adding 1000g in the mixture after pulverizing, decoct 3 hours, filters, and in filter residue, adds the water of 400g again to decoct 2 hours, filters, and twice filtrate is mixed, and is evaporated to the decoction that crude drug concentration is 1.5g/ml.
The preparation of embodiment 3 Chinese traditional medicine composition composition powders 1
The 390g coptis, 190g kuh-seng, the 490g Chinese bulbul, the 420g wind-weed, 210g selfheal, 300g honeysuckle, 180g radix scrophulariae, 320g Radix Codonopsis, the 260g bighead atractylodes rhizome, 220g lotus seeds, 180g dark plum, 160g granatum, 140g coix seed mix, and pulverize; To the water that adds 10000g in the mixture after pulverizing, decoct 3 hours, filter, in filter residue, add the water of 4000g again to decoct 2 hours, filter, twice filtrate is mixed, reduced pressure concentration anhydrates minute, obtain dry lotion, further and pulverizing dry with spray dryer, sieve and obtain 70 order Chinese traditional medicine composition composition powders fine powders 1.
The preparation of embodiment 4 Chinese traditional medicine composition composition powders 2
The 360g coptis, 160g kuh-seng, the 460g Chinese bulbul, the 390g wind-weed, 190g selfheal, 260g honeysuckle, 150g radix scrophulariae, 280g Radix Codonopsis, the 230g bighead atractylodes rhizome, 190g lotus seeds, 150g dark plum, 130g granatum, 120g coix seed mix, and pulverize; To the water that adds 9000g in the mixture after pulverizing, decoct 3 hours, filter, in filter residue, add the water of 350g again to decoct 2 hours, filter, twice filtrate is mixed, reduced pressure concentration anhydrates minute, obtain dry lotion, further and pulverizing dry with spray dryer, sieve and obtain 50 order Chinese traditional medicine composition composition powders fine powders 2.
The preparation of embodiment 5 fodder compounds 1
Get the Chinese traditional medicine composition composition powders 1 of embodiment 3 preparations, dry rear standby; 300gL-lactic acid, 200g fumaric acid, 250g citric acid are mixed, add 1000g water mixing and stirring, send into the spraying granulation tower and carry out spraying granulation, the particle drying made, and sieve, obtain 70 purpose acidulants; Getting 700g Strong flour, 400g cornstarch, 20g ammonium sulfate and 40g sodium acid carbonate mixes, wherein farinose ratio of weight and number is 80 parts, the ratio of weight and number of ripe starch is 20 parts, Strong flour is the flour that the protein wt degree is 17%, add 300g water to start modified, refining temperature is 68 ℃, and the rear dry feed adhesive that obtains stirs; After 3000g wheat bran, 700g corn, 600g wheat, 1500g soybean, 200g Chinese sorghum are mixed, pulverize, grinding particle size is 300mm, makes its fine powder amount reach 95% of total material, obtains feed vector; By 350g Chinese traditional medicine composition composition powders 1,150g acidulant, 750g feed adhesive; the 5000g feed vector mixes; put between the multiplex mixer stirring; the expanded time is 2 hours; the aridity of controlling material to be extruded is 95%; proceed to after taking-up in ring mode grit machine and be produced into precipitation hard particles feed, then sieve by 50 meshes, obtain described fodder compound 1.
The preparation of embodiment 6 fodder compounds 2
Get the Chinese traditional medicine composition composition powders 2 of embodiment 4 preparations, dry rear standby; 300gL-lactic acid, 200g fumaric acid, 250g citric acid are mixed, add 1000g water mixing and stirring, send into the spraying granulation tower and carry out spraying granulation, the particle drying made, and sieve, obtain 70 purpose acidulants; Getting 700g Strong flour, 400g cornstarch, 20g ammonium sulfate and 40g sodium acid carbonate mixes, wherein farinose ratio of weight and number is 80 parts, the ratio of weight and number of ripe starch is 20 parts, Strong flour is the flour that the protein wt degree is 17%, add 300g water to start modified, refining temperature is 68 ℃, and the rear dry feed adhesive that obtains stirs; After 3000g wheat bran, 700g corn, 600g wheat, 1500g soybean, 200g Chinese sorghum are mixed, pulverize, grinding particle size is 300mm, makes its fine powder amount reach 95% of total material, obtains feed vector; By 350g Chinese traditional medicine composition composition powders 2,150g acidulant, 750g feed adhesive; the 5000g feed vector mixes; put between the multiplex mixer stirring; the expanded time is 2 hours; the aridity of controlling material to be extruded is 95%; proceed to after taking-up in ring mode grit machine and be produced into precipitation hard particles feed, then sieve by 50 meshes, obtain described fodder compound 2.
Embodiment 7 clinical trials
Experiment material
Bacterial strain: the chick that dies from the white scour of chicken from locality separates identifies the white diarrhea Salmonella, puts 37 ℃ of cultivation 24 ~ 48h with broth medium standby.
Medicine:
Western medicine: berberine 10mg/mL, furazolidone 20mg/mL;
Chinese medicine: the Chinese medicine composition decoction of the embodiment of the present invention 2 preparations.
The prevention experiment:
200 healthy parts in Beijing opera spoken in Beijing dialect chick (5 age in days) are divided into to 4 groups at random, and Chinese medicine of the present invention is attacked every of poison group 2mL decoction every day, and Western medicine is attacked poison group furazolidone group and fed to account for 0.02% of feed; The blank group is not fed any medicine, Chinese medicine is attacked malicious group, Western medicine and is attacked malicious group, not administration and attack malicious group, after medication 4d, with 5 times of dilutions of above-mentioned Salmonella broth culture (1,000,000,000 bacterium/mL), lumbar injection 0.3mL/ only, fall ill and dead chicken number by each group of observed and recorded.
The treatment experiment:
To be divided at random 3 groups with 300 (5 age in days) parts in Beijing opera spoken in Beijing dialect chick of Salmonella cultured solution of broth lumbar injection, and occur treating with different medicines after clinical symptom.The test chicken dose: every for the treatment of by Chinese herbs group of the present invention 3mL decocting liquid every day, furazolidone group medicine accounts for 0.04% of feed, and control group is not fed any medicine.
Result:
The preventive effect of Chinese herbs decoction of the present invention to white diarrhea, the results are shown in Table 1.
Table 1 white diarrhea preventive effect
Known by table 1, Chinese medicine composition decoction of the present invention will have good effect significantly better than the Western medicine group to the preventive effect of white diarrhea, and the Chinese medicine composition decoction is higher than Western medicine antibacterials to the preventive effect of white diarrhea salmonellosis.
The result for the treatment of of Chinese herbs decoction of the present invention to white diarrhea, the results are shown in Table 2.
Table 2 white diarrhea result for the treatment of
Known by table 2, Chinese medicine composition decoction of the present invention will be significantly better than the Western medicine group to the result for the treatment of of white diarrhea, and the Chinese medicine composition decoction is higher than Western medicine antibacterials to the result for the treatment of of white diarrhea salmonellosis.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (7)
- One kind the prevention and the treatment white diarrhea Chinese medicine, it is characterized in that: described Chinese medicine only consists of the coptis, kuh-seng, the Chinese bulbul, the wind-weed, selfheal, honeysuckle, radix scrophulariae, Radix Codonopsis, the bighead atractylodes rhizome, lotus seeds, dark plum, granatum and coix seed;The parts by weight of each component in described Chinese medicine are, the coptis 33～39 weight portions, kuh-seng 13～19 weight portions, the Chinese bulbul 42～49 weight portions, the wind-weed 36～42 weight portions, selfheal 17～21 weight portions, honeysuckle 23～30 weight portions, radix scrophulariae 12～18 weight portions, Radix Codonopsis 25～32 weight portions, the bighead atractylodes rhizome 20～26 weight portions, lotus seeds 15～22 weight portions, dark plum 13～18 weight portions, granatum 10～16 weight portions, coix seed 9～14 weight portions.
- 2. Chinese medicine as claimed in claim 1, it is characterized in that: the parts by weight of each component in described Chinese medicine are, the coptis 36～39 weight portions, kuh-seng 16～19 weight portions, the Chinese bulbul 46～49 weight portions, the wind-weed 39～42 weight portions, selfheal 19～21 weight portions, honeysuckle 26～30 weight portions, radix scrophulariae 15～18 weight portions, Radix Codonopsis 28～32 weight portions, the bighead atractylodes rhizome 23～26 weight portions, lotus seeds 19～22 weight portions, dark plum 15～18 weight portions, granatum 13～16 weight portions, coix seed 12～14 weight portions.
- 3. the preparation method of claim 1 or 2 described Chinese medicine is characterized in that:When the formulation of described Chinese medicine is decoction, comprise,The first step, mix described component in proportion, pulverizes;Second step, add the water with respect to 2～4 times of described mixture qualities in the mixture after pulverizing, decoct 2～4 hours, filter, in filter residue, add the water with respect to 1～2 times, described mixture again to decoct 1～2 hour, filter, twice filtrate is mixed, being evaporated to crude drug concentration is 1g/ml～3g/ml.
- 4. the preparation method of claim 1 or 2 described Chinese medicine is characterized in that:When the formulation of described Chinese medicine is powder, comprise,The first step, drop in proportion mixer by described component and stir 30～50 minutes, fully mixes, and pulverizes;Second step, add the water with respect to 2～4 times of described mixture qualities in the mixture after pulverizing, decoct 2～4 hours, filter, in filter residue, add the water with respect to 1～2 times, described mixture again to decoct 1～2 hour, filter, twice filtrate is mixed, and reduced pressure concentration is removed moisture, obtains dry lotion, further and pulverizing dry with spray dryer, sieve and obtain 50～100 order traditional Chinese powder medicine fine powders.
- 5. a feed, it is characterized in that: comprise feed addictive and feed vector, described feed addictive comprises that the described Chinese medicine of claim 1 or 2 is as additive.
- 6. feed as claimed in claim 5, it is characterized in that: with respect to the feed addictive of 100 weight portions, the addition of described Chinese medicine additive is 30～70 weight portions.
- 7. feed as claimed in claim 6, it is characterized in that: also comprise acidulant in described feed addictive, feed addictive with respect to 100 weight portions, the addition of described acidulant is 10～30 weight portions, described acidulant comprises one or more mixing in Pfansteihl, fumaric acid, citric acid, and when described acidulant is the mixture of above-mentioned several materials, the parts by weight of each component are Pfansteihl 25～35 weight portions, fumaric acid 15～30 weight portions, citric acid 20～30 weight portions.
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| CN103055108B (en) * | 2012-12-04 | 2014-07-09 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating dysentery of livestock and poultry and preparation method of compound propolis composition |
| CN103518995A (en) * | 2013-08-31 | 2014-01-22 | 安徽晨诺饲料油脂加工有限公司 | Traditional Chinese herbal feed for preventing and treating white diarrhea of chicks and preparation method for feed |
| CN103478508B (en) * | 2013-10-22 | 2015-04-15 | 山东新希望六和集团有限公司 | Chinese medicinal composition and feed for improving chicken immunity and preparation method of composition and feed |
| CN105230569A (en) * | 2015-11-11 | 2016-01-13 | 覃政强 | Broiler chicken breeding method |
| CN105284727A (en) * | 2015-11-11 | 2016-02-03 | 覃政强 | Broiler chicken breeding method |
| CN105494950A (en) * | 2015-12-23 | 2016-04-20 | 铜陵润生生态养殖有限公司 | Chicken feed additive for preventing avian staphylocosis and pullorum disease |
| CN106071090A (en) * | 2016-07-13 | 2016-11-09 | 王达文 | A kind of anti-diarrhea Chinese medicine compound feed additive and preparation method and application |
| CN106615912A (en) * | 2016-09-30 | 2017-05-10 | 安徽华澳生物技术有限公司 | Feed additive for preventing and treating pullorum disease of chicks of 1-30 days old |
| CN106982987A (en) * | 2017-03-29 | 2017-07-28 | 安徽省微科生物科技有限公司 | A kind of feed addictive for preventing and treating DISEASE IN FLOCKS |
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