CN103829092B - Traditional Chinese medicinal composition and feed for treating escherichia coli diarrhea of piglets - Google Patents
Traditional Chinese medicinal composition and feed for treating escherichia coli diarrhea of piglets Download PDFInfo
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- CN103829092B CN103829092B CN201410078747.9A CN201410078747A CN103829092B CN 103829092 B CN103829092 B CN 103829092B CN 201410078747 A CN201410078747 A CN 201410078747A CN 103829092 B CN103829092 B CN 103829092B
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
The invention provides a traditional Chinese medicinal composition for treating escherichia coli diarrhea of piglets. The traditional Chinese medicinal composition comprises liquorice, herba houttuyniae, sophora flavescens, acanthopanax, puerarin, semen coicis, coriolus versicolor, jasmines, endothelium corneum gigeriae galli, cortex phellodendri, dandelion, selaginella tamariscina, polygonatum kingianum, eclipta, companumoea root, bauhinia championii, astragalus complanatus, fructus psoraleae, rosa laevigata michx, pericarpium granati, honeysuckle, pipewort, sedum verticallatum, leonurus and morinda officinalis. The traditional Chinese medicinal composition additive is low in cost and does not have residue and drug resistance; compared with the antibiotic and other chemical synthesized medicines, the traditional Chinese medicinal composition contains multiple effective components and can achieve a comprehensive prevention and treatment effect; meanwhile, the whole function of an animal organism can be improved; the traditional Chinese medicinal composition realizes a giant function in modern breeding production.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of Chinese medicine composition and the feed that are used for the treatment of coliform diarrhea in piglets.
Background technology
Coliform diarrhea in piglets is a kind of acute, infectious disease that the death rate is high caused by enteropathogenic E. Coli, all generally occur all over the world, especially in the China that breeding environment is not too perfect, often cause large quantities of piglet depauperation or death, cause huge economic loss to pig industry.
In order to control this disease, mostly adopting antibiosis usually to treat coliform diarrhea in piglets, strengthening feeding and management simultaneously, environment is entered
Row strict sterilization also can reduce its incidence of disease.But along with antibiotic unreasonable use, cause the generation of a large amount of antibody-resistant bacterium, make original
There is the antibiotic active force of good result to decline to this disease of control, weaken at some pig farm successful or there is no effect at all.The generation of bacterial drug resistance and transfer, people, after a large amount of livestock products of searching for food, when corresponding bacteriological infection, makes people reduce some antibiotic sensitiveness, difficulty is caused, the concern that the food-safety problem caused thus also causes people enough to the control of human diseases.In addition, medicine residual in livestock products, can cause allergy and allergic reaction, and the three-induced effect such as carcinogenic, teratogenesis, mutagenesis, brings very large potential hazard to human body health.Due to long-term abuse of antibiotics in breeding process unreasonably, adverse effect is brought to the health of pig industry, sustainable development, make the livestock products drug residue amount severe overweight produced, the cost of cultivation is increased, the prevention and control difficulty of disease strengthens, and both result in the pollution aggravation of environment, and has compromised the health of mankind itself, also have impact on outlet, cause far-reaching political fallout and serious economic loss to the Chinese government.
The antibacterials being commonly used to treat coliform diarrhea in piglets clinically depend on their bacteriostasis, antimicrobial has in use not only killed pathogenic bacteria, also the original normal flora of body can be destroyed, cause the destruction of microecological balance in body, and then add the sensitiveness that body infects external source, simultaneously due to Long-Time Service antimicrobial, pathogen can be made to produce drug resistance, produce little effect, the therapeutic action of Chinese herbal medicine is then many-sided, and its mechanism of action is very complicated.
In China, have the history of several thousand by the disease of Chinese herbal medicine prevention and therapy animal.Chinese herbal medicine resource enriches, and has cost low, noresidue, has no drug resistance, and for antibiotic and other chemical synthetic drug, the active ingredient that Chinese herbal medicine contains is more, can play comprehensive preventive and therapeutic effect.The toxicity of Chinese herbal medicine is lower, can play comprehensive effect, and can improve the allomeric function of animal body, play huge effect in modern breeding production in the process of prevention, disease therapy.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition additive being used for the treatment of coliform diarrhea in piglets, cost is low, noresidue, have no drug resistance, for antibiotic and other chemical synthetic drug, the active ingredient that Chinese herbal medicine contains is more, comprehensive preventive and therapeutic effect can be played, meanwhile, it can improve the allomeric function of animal body, plays huge effect in modern breeding production.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition being used for the treatment of coliform diarrhea in piglets, its bulk drug comprises: Radix Glycyrrhizae, cordate houttuynia, kuh-seng, wilsonii, the root of kudzu vine, coix seed, rainbow conk, cape jasmine, the membrane of a chicken's gizzard, golden cypress, dandelion, Selaginella tamariscina, sealwort, eclipta, Companumoea root, champion bauhinia stem, semen astragali complanati, Psoralea corylifolia, the fruit of Cherokee rose, granatum, honeysuckle, pipewort, stringy stonecrop, motherwort and Morinda officinalis.Chinese medicine composition provided by the invention can strengthening vital QI to eliminate pathogenic factors, clearing heat and detoxicating, and sterilization is antibacterial, improve Abwehrkraft des Koepers, strengthen immunologic function, well treats coliform diarrhea in piglets.
Wherein, in described Chinese medicine composition, the weight of each bulk drug is respectively Radix Glycyrrhizae 10g ~ 20g, cordate houttuynia 20g ~ 30g, kuh-seng 25g ~ 35g, wilsonii 35g ~ 45g, root of kudzu vine 20g ~ 30g, coix seed 35g ~ 45g, rainbow conk 10g ~ 20g, cape jasmine 35g ~ 45g, the membrane of a chicken's gizzard 25g ~ 35g, golden cypress 55g ~ 65g, dandelion 45g ~ 55g, Selaginella tamariscina 15g ~ 25g, sealwort 20g ~ 30g, eclipta 25g ~ 35g, Companumoea root 20g ~ 30g, champion bauhinia stem 15g ~ 25g, semen astragali complanati 20g ~ 30g, Psoralea corylifolia 25g ~ 35g, fruit of Cherokee rose 20g ~ 30g, granatum 20g ~ 30g, honeysuckle 30g ~ 40g, pipewort 15g ~ 25g, stringy stonecrop 10g ~ 20g, motherwort 20g ~ 30g and Morinda officinalis 15g ~ 25g.
Wherein, in described Chinese medicine composition, the weight of each bulk drug is respectively Radix Glycyrrhizae 15g, cordate houttuynia 25g, kuh-seng 30g, wilsonii 40g, root of kudzu vine 25g, coix seed 40g, rainbow conk 15g, cape jasmine 40g, the membrane of a chicken's gizzard 30g, golden cypress 60g, dandelion 50g, Selaginella tamariscina 20g, sealwort 25g, eclipta 30g, Companumoea root 25g, champion bauhinia stem 20g, semen astragali complanati 25g, Psoralea corylifolia 30g, fruit of Cherokee rose 25g, granatum 25g, honeysuckle 35g, pipewort 20g, stringy stonecrop 15g, motherwort 25g and Morinda officinalis 20g.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, be specially:
The first step, cordate houttuynia, kuh-seng, coix seed, Companumoea root, champion bauhinia stem, Psoralea corylifolia, the fruit of Cherokee rose, granatum and honeysuckle are mixed by weight, obtain mixture, add determining alcohol be 50% ~ 70% ethanolic solution carry out heating and refluxing extraction 2 times, each refluxing extraction 2h ~ 3h, the amount of the mixture interpolation ethanolic solution of every 1kg is 3L ~ 5L, and the extract of acquisition merges and filters;
Second step, remaining bulk drug component is mixed by weight, obtain mixture, add water and decoct, decoct 3 times, each decoction 2h ~ 3h, the amount of the mixture interpolation water of every 1kg is 2L ~ 4L, and decoction liquor merges, and filters, relative density when filtrate is concentrated into 70 ~ 90 DEG C is 1.25 ~ 1.30, obtains concentrate;
3rd step, joins the extract of first step gained in the concentrate of second step acquisition, stirs, and leaves standstill 24h, reclaims ethanol and concentrates, being condensed into thick paste, dry, pulverize into fine powder, acquisition Chinese medicine composition.
The present invention also provides a kind of feed being used for the treatment of coliform diarrhea in piglets, and its raw material comprises wheat, rice bran, the dish dregs of rice, fish meal, calcium monohydrogen phosphate, salt, B B-complex, composite trace element and Chinese medicine composition additive.
Wherein, in described feed, the weight of each raw material is respectively wheat 6kg ~ 8kg, rice bran 1kg ~ 2kg, dish dregs of rice 1.0kg ~ 1.2kg, fish meal 0.6kg ~ 0.8kg, calcium monohydrogen phosphate 0.05kg ~ 0.15kg, salt 0.05kg ~ 0.15kg, B B-complex 0.2kg ~ 0.4kg, composite trace element 0.1kg ~ 0.2kg, Chinese medicine composition additive 0.8kg ~ 1.2kg.
Wherein, in described feed, the weight of each raw material is respectively wheat 7kg, rice bran 1.5kg, dish dregs of rice 1.2kg, fish meal 0.7kg, calcium monohydrogen phosphate 0.1kg, salt 0.1kg, B B-complex 0.3kg, composite trace element 0.15kg, Chinese medicine composition additive 1.0kg.
Present invention also offers the preparation method of above-mentioned feed, be specially:
The first step, prepares Chinese medicine composition additive according to the method described above;
Second step, each raw material got except described Chinese medicine composition additive in described feed is first pulverized, and then the raw material after pulverizing is put into mixer and mixes, add Chinese medicine composition additive prepared by the first step again to mix further, mixed material enters modulator, and refining temperature is 70 DEG C, modulating time 10 seconds, after modulation, send into slaking tank and carry out slaking, the curing time is 5 minutes, curing temperature 70 DEG C, finally enter pellet fabrication device to granulate, obtain finished product feedstuff.
Beneficial effect of the present invention:
Chinese medicine composition additive provided by the invention, its cost is low, noresidue, have no drug resistance, for antibiotic and other chemical synthetic drug, the active ingredient that Chinese herbal medicine contains is more, comprehensive preventive and therapeutic effect can be played, meanwhile, it can improve the allomeric function of animal body, plays huge effect in modern breeding production.
Detailed description of the invention
The invention provides a kind of Chinese medicine composition being used for the treatment of coliform diarrhea in piglets, its bulk drug comprises: Radix Glycyrrhizae, cordate houttuynia, kuh-seng, wilsonii, the root of kudzu vine, coix seed, rainbow conk, cape jasmine, the membrane of a chicken's gizzard, golden cypress, dandelion, Selaginella tamariscina, sealwort, eclipta, Companumoea root, champion bauhinia stem, semen astragali complanati, Psoralea corylifolia, the fruit of Cherokee rose, granatum, honeysuckle, pipewort, stringy stonecrop, motherwort and Morinda officinalis.Chinese medicine composition provided by the invention can strengthening vital QI to eliminate pathogenic factors, clearing heat and detoxicating, and sterilization is antibacterial, improve Abwehrkraft des Koepers, strengthen immunologic function, well treats coliform diarrhea in piglets.
Wherein, in described Chinese medicine composition, the weight of each bulk drug is respectively Radix Glycyrrhizae 10g ~ 20g, cordate houttuynia 20g ~ 30g, kuh-seng 25g ~ 35g, wilsonii 35g ~ 45g, root of kudzu vine 20g ~ 30g, coix seed 35g ~ 45g, rainbow conk 10g ~ 20g, cape jasmine 35g ~ 45g, the membrane of a chicken's gizzard 25g ~ 35g, golden cypress 55g ~ 65g, dandelion 45g ~ 55g, Selaginella tamariscina 15g ~ 25g, sealwort 20g ~ 30g, eclipta 25g ~ 35g, Companumoea root 20g ~ 30g, champion bauhinia stem 15g ~ 25g, semen astragali complanati 20g ~ 30g, Psoralea corylifolia 25g ~ 35g, fruit of Cherokee rose 20g ~ 30g, granatum 20g ~ 30g, honeysuckle 30g ~ 40g, pipewort 15g ~ 25g, stringy stonecrop 10g ~ 20g, motherwort 20g ~ 30g and Morinda officinalis 15g ~ 25g.
Wherein, in described Chinese medicine composition, the weight of each bulk drug is respectively Radix Glycyrrhizae 15g, cordate houttuynia 25g, kuh-seng 30g, wilsonii 40g, root of kudzu vine 25g, coix seed 40g, rainbow conk 15g, cape jasmine 40g, the membrane of a chicken's gizzard 30g, golden cypress 60g, dandelion 50g, Selaginella tamariscina 20g, sealwort 25g, eclipta 30g, Companumoea root 25g, champion bauhinia stem 20g, semen astragali complanati 25g, Psoralea corylifolia 30g, fruit of Cherokee rose 25g, granatum 25g, honeysuckle 35g, pipewort 20g, stringy stonecrop 15g, motherwort 25g and Morinda officinalis 20g.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, be specially:
The first step, cordate houttuynia, kuh-seng, coix seed, Companumoea root, champion bauhinia stem, Psoralea corylifolia, the fruit of Cherokee rose, granatum and honeysuckle are mixed by weight, obtain mixture, add determining alcohol be 50% ~ 70% ethanolic solution carry out heating and refluxing extraction 2 times, each refluxing extraction 2h ~ 3h, the amount of the mixture interpolation ethanolic solution of every 1kg is 3L ~ 5L, and the extract of acquisition merges and filters;
Second step, remaining bulk drug component is mixed by weight, obtain mixture, add water and decoct, decoct 3 times, each decoction 2h ~ 3h, the amount of the mixture interpolation water of every 1kg is 2L ~ 4L, and decoction liquor merges, and filters, relative density when filtrate is concentrated into 70 ~ 90 DEG C is 1.25 ~ 1.30, obtains concentrate;
3rd step, joins the extract of first step gained in the concentrate of second step acquisition, stirs, and leaves standstill 24h, reclaims ethanol and concentrates, being condensed into thick paste, dry, pulverize into fine powder, acquisition Chinese medicine composition.
The present invention also provides a kind of feed being used for the treatment of coliform diarrhea in piglets, and its raw material comprises wheat, rice bran, the dish dregs of rice, fish meal, calcium monohydrogen phosphate, salt, B B-complex, composite trace element and Chinese medicine composition additive.
Wherein, in described feed, the weight of each raw material is respectively wheat 6kg ~ 8kg, rice bran 1kg ~ 2kg, dish dregs of rice 1.0kg ~ 1.2kg, fish meal 0.6kg ~ 0.8kg, calcium monohydrogen phosphate 0.05kg ~ 0.15kg, salt 0.05kg ~ 0.15kg, B B-complex 0.2kg ~ 0.4kg, composite trace element 0.1kg ~ 0.2kg, Chinese medicine composition additive 0.8kg ~ 1.2kg.
Wherein, in described feed, the weight of each raw material is respectively wheat 7kg, rice bran 1.5kg, dish dregs of rice 1.2kg, fish meal 0.7kg, calcium monohydrogen phosphate 0.1kg, salt 0.1kg, B B-complex 0.3kg, composite trace element 0.15kg, Chinese medicine composition additive 1.0kg.
Described B B-complex is combined by one or more in vitamin A, vitamine D3, Vitamin K3, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, pantothenic acid, folic acid, biotin, pig is provided to grow necessary vitamin, also can be vitamin premix, as excellent dimension element (Beijing You Libao biotechnology Co., Ltd provides); Described composite trace element is ferric sulfate, one or more in manganese sulfate, zinc sulfate, sodium selenite, cobalt chloride, calcium iodate combine, pig is provided to grow required trace element, as excellent profit protects (Beijing You Libao biotechnology Co., Ltd provides).
Present invention also offers the preparation method of above-mentioned feed, be specially:
The first step, prepares Chinese medicine composition additive according to the method described above;
Second step, each raw material got except described Chinese medicine composition additive in described feed is first pulverized, and then the raw material after pulverizing is put into mixer and mixes, add Chinese medicine composition additive prepared by the first step again to mix further, mixed material enters modulator, and refining temperature is 70 DEG C, modulating time 10 seconds, after modulation, send into slaking tank and carry out slaking, the curing time is 5 minutes, curing temperature 70 DEG C, finally enter pellet fabrication device to granulate, obtain finished product feedstuff.
In described Chinese medicine composition, the pharmacology of each bulk drug is as follows:
Radix Glycyrrhizae: taste is sweet, property put down, enter 12 warps, have clearing heat and detoxicating, be in harmonious proportion the property of medicine, the effect of expelling phlegm and arresting coughing, and can invigorating the spleen and in, relieving spasm to stop pain, is mainly used in weakness of the spleen and the stomach abdominal distension and anorexia, weak; Contraction pain in abdomen being alleviated, relax the strong and toxicity of some drugs, alleviate medicine to the toxic and side effect of body or to GI stimulation, tonifying Qi neutralization can be played by adding Radix Glycyrrhizae, be in harmonious proportion the work of each component.
Cordate houttuynia: taste is pungent, cold nature, enters lung, urinary bladder channel, has clearing heat and detoxicating, removing pus and relieving carbuncle, effect of inducing diuresis for treating strangurtia, and for lung carbuncle pyemesis, phlegm heat is coughed and breathed heavily, toxic-heat and blood stasis, damp-heat gonorrhoea, hot carbuncle carbuncle, and snakeworm wants first-class card.
Kuh-seng: bitter, cold in nature, enter the heart, stomach, large intestine, urinary bladder channel, there is the effect of heat-clearing and damp-drying drug, wind dispelling insecticide, be mainly used in damp-heat dysentery, jaundice, stranguria, kuh-seng has obvious inhibitory action to shigella dysenteriae, Escherichia coli, proteus, beta streptococcus and staphylococcus aureus.
Wilsonii: taste is pungent, bitter, micro-sweet, warm in nature, enters spleen, kidney, the heart channel of Hang-Shaoyin, have and replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain, the effect of dispelling rheumatism, soft for wind-cold-dampness arthralgia, lumbocrural pain, muscles and bones impotence, be slow in action, the card such as body void is thin and weak, traumatic injury, fracture, oedema, beriberi, uncontrolled urination are itched.
The root of kudzu vine: taste is sweet, pungent, cool in nature, enter spleen, stomach warp, have inspiration stomach Qi, clearing heat and promoting fluid, expelling pathogenic factors from muscles and skin is delivered, and raw sun, oozes the effect of rash, be mainly used in fever caused by exogenous pathogens, headache, stiff nape and back, and pyreticosis is thirsty, quenches one's thirst; Splenasthenic diarrhea, the cards such as lucid yang failing to raise.
Coix seed: taste is sweet, light, cold nature, enters lung, spleen, large intestine channel, has invigorating the spleen to arrest diarrhea, and Li Shui is except numbness, and the effect of row's sore purulence, is mainly used in having loose bowels of wet tired lung stomach; Damp evil invades the anasarca of stain skin, difficult urination; The damp and hot numbness hindered in qi and blood passes to and the scorchingly hot card such as lung carbuncle, acute appendicitis pented up in lung intestines.
Rainbow conk: taste is sweet, light, cold nature, returns liver; Spleen; Lung channel, has invigorating spleen to remove dampness; Relieving cough and asthma; Clearing heat and detoxicating; Antineoplastic effect, cures mainly CAH; Cirrhosis; Chronic bronchitis; Infantile spasm bronchitis; Abscess of throat; Kinds of tumors; Rheumatoid arthritis; The cards such as leukaemia.
Cape jasmine: bitter, cold in nature, enter the heart, lung, three burnt, have the effect of relieving restlessness purging intense heat, soothing liver-qi stagnation, clearing heat and promoting diuresis, cooling blood and hemostasis, be mainly used in the vexed uneasiness of the strongly fragrant chest gastral cavity of warm heat disease heat, bother not peaceful; Hot and suffocating in stomach, the lips are dry and the mouth is parched, aphtha halitosis; Liver depression is not relaxed or Liver Channel has having a dizzy spell of heat, pain in chest and hypochondrium, hot eyes dry throat; Jaundice with damp-heat pathogen; The cards such as the abdominal distention of qi depression to blood stasis.
The membrane of a chicken's gizzard: taste is sweet, cold in nature, enter spleen, stomach, small intestine, urinary bladder channel, the effect having reinforcing spleen to promote digestion, puckery essence only to drown, is mainly used in the abdominal fullness and distention of dyspepsia stagnation, and heating installation is suffered from diarrhoea, the symptoms such as infant malnutrition, the membrane of a chicken's gizzard can promote gastric secretion, strengthens peristole, accelerate the effects such as gastric emptying.
Golden cypress: bitter, cold in nature, enter kidney, bladder, large intestine channel, heat-clearing and damp-drying drug, purging intense heat and detonicating, except hectic fever due to yin clearind deficient heat.For damp-heat dysentery, jaundice, under band, heat is drenched, beriberi, and impotence is warded off, hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema itch.Stir-baked CORTEX PHELLODENDRI with salt solution is nourishing Yin and falling fire.For fire excess from yin deficiency, the cards such as night sweat hectic fever due to yin.
Dandelion: taste is sweet, bitter, cold in nature, enter liver, stomach warp, have clearing heat and detoxicating, the carbuncle that disappears dissipating bind, clear liver and improve vision, the effect of inducing diuresis for treating strangurtia, be mainly used in the treatment of sore swollen toxin, especially remarkable to acute mastitis effect, also can be used for the treatment of the symptoms such as the red eye, swell pain of liver-fire flaming, in addition, also there is the effect of promoting urination and removing dampness, for controlling jaundice with damp-heat pathogen, difficult urination, the treatment of the illnesss such as urinary system infection contamination, common reply Gold production staphylococcus, Escherichia coli, Pseudomonas aeruginosa, shigella flexneri, paratyphoid A, Candida albicans Niu Jun, ox type Brucella has certain bacteriostasis, to Trichophyton concentricum, haze achorion, the little Bacillus of rust, gypsum sample little gemma tinea bacterium etc. all have bacteriostasis perhaps.
Selaginella tamariscina: taste is pungent, property is put down, and returns liver, the heart channel of Hang-Shaoyin, has effect of activating blood to promote menstruation.For through closing dysmenorrhoea.Wei lump in the abdomen lump in the abdomen, injury from falling down, spit blood, uterine bleeding, has blood in stool, the cards such as prolapse of the anus.
Sealwort: taste is sweet, property is put down, and enters lung, spleen, kidney channel, has enriching qi and yin, invigorating the spleen moistening lung, effect of enriching kidney essence, for taste deficiency of qi and yin, food is few unable, the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.
Eclipta: taste is sweet, sour, cold in nature, returns liver, kidney channel, plays not liver and kidney benefiting, the effect of cooling blood and hemostasis, for having a dizzy spell caused by the deficiency of liver-yin and kidney-yin, blurring of vision, and soreness and weakness of waist and knees; Be suitable for the deficiency of Yin and have hot person, be used for the treatment of the haematemesis of accumulated heat in stomach, the symptoms such as the hemoptysis of heat impairing pulmonary collateral, eclipta has inhibitory action to staphylococcus aureus, typhoid bacillus, S. sonnei, Pseudomonas aeruginosa, can obviously strengthen nospecific immunity and cellular immune function.
Companumoea root: taste is sweet, property is put down, and returns lung, the spleen channel, has strengthening the spleen and replenishing qi, tonifies the lung to relieve cough, effect of lactogenesis, and cure mainly the empty internal injury of labor, the deficiency of vital energy is weak, palpitaition, hidrosis, splenasthenic diarrhea, leukorrhea, and milk is rare, the cards such as insufficiency of the spleen cough.
Champion bauhinia stem: bitter, pungent, property is put down, and have and dispel rheumatism, effect of the promoting flow of qi and blood circulation, cures mainly arthralgia due to wind-dampness, traumatic injury, hemiplegia, epigastric pain, infantile malnutrition due to digestive disturbances or intestinalparasites, the cards such as dysentery.
Semen astragali complanati: warm in nature, taste is sweet, has warm filling liver kidney, controlling nocturnal emission with astringent drugs, contracting urine, the effect of improving eyesight, for impotence due to deficiency of the kidney, seminal emission premature ejaculation, frequent micturition, or leukorrhea, soreness and weakness of waist and knees, pain in the back; Kidney deficiency and liver, blurred vision order is dark, the cards such as hypopsia.
Psoralea corylifolia: taste is pungent, bitter, warm in nature, enters kidney, the spleen channel, has tonifying kidney and strengthening yang, and warming spleen and stopping diarrha effect, is mainly used in the Yang-function insufficiency of kidneyzang, the waist knee crymodynia of below element deficiency and cold, frequent urination and enuresis, impotence lingering diarrhea; The stomachache limb that the insufficiency of the kidney yang, spleen soil loses temperature is trembled with fear, and Diarrhoea, Psoralea corylifolia also has the effect of antidiarrheal.
The fruit of Cherokee rose: taste is sour, sweet, property is puckery, flat, returns kidney, bladder, large intestine channel, and have controlling nocturnal emission with astringent drugs contracting urine, curing metrorrhagia and leukorrhagia, effect of relieving diarrhea with astringents, cures mainly emission and spermatorrhea, enuresis frequent micturition, under uterine bleeding band, rushes down the cards such as protracted dysentery for a long time.
Granatum: taste acid, puckery, warm in nature, enter large intestine, kidney channel, there is relieving diarrhea with astringents, effect of hemostasis desinsection, for rushing down protracted dysentery for a long time, hematochezia, under uterine bleeding band, the cards such as abdominal pain due to enterositosis.
Honeysuckle: taste is sweet, cold in nature, enters the heart, lung, stomach, large intestine channel, has clearing heat and detoxicating effect, doublely can remove heat from the blood and relieve diarrhea.Be mainly used in affection of exogenous wind-heat, the hot poison of warm heat disease is comparatively contained, or when warm disease is still not descending at the part of the body cavity above the diaphragm housing the heart and lungs from the beginning of heat evil; The malicious diarrhea of heat, the lower blood of stool; Heat temperature is demonstrate,proved; The sore carbuncle that hot poison gathers is from the beginning of the, inflammation heat person of swelling and ache etc., honeysuckle has good antipyretic effect, energy anti-inflammatory, what control inflammation oozes out and inflammatory hyperplasia, leukocytic phagocytic function can be promoted, there is stronger bacteriostasis to multiple pyococcus and pathogenic entero becteria, comprise staphylococcus, hemolytic streptococcus, diplococcus meningitidis, shigella dysenteriae, typhoid bacillus, ewcastle disease, Pseudomonas aeruginosa, tubercle bacillus etc.
Pipewort: taste is pungent, sweet, property is put down, return liver, stomach warp, there is the effect of wind-dispelling heat-dissipating, removing nebula, for cards such as red eye, swell pain, the many tear of photophobia, headache due to pathogenic wind-heat, toothache, there is stronger inhibitory action to staphylococcus aureus, bacterium flexneri, typhoid bacillus, Escherichia coli, Pseudomonas aeruginosa etc.
Stringy stonecrop: taste is sweet, light, cool in nature, returns liver, courage, small intestinl channel, has eliminating dampness and heat, and effect of removing toxic substances, cures mainly jaundice with damp-heat pathogen, difficult urination, and carbuncle swells the cards such as sore, acute hepatitis, chronic hepatitis, and stringy stonecrop has the effect protecting liver and immunity.
Motherwort: bitter, pungent, cold nature, enters liver, pericardium channel, has promoting blood circulation for regulating menstruation, and effect of inducing diuresis to reduce edema, cures mainly irregular menstruation, dysmenorrhoea, through closing, lochiorrhagia, oedema oliguria, the cards such as acute nephritis edema.
Morinda officinalis: taste is pungent, sweet, slightly warm in nature, enters liver, kidney channel, has the effect of kidney-replenishing, strengthening the bones and muscles, wines used as antirheumatic, and for impotence due to deficiency of the kidney, seminal emission premature ejaculation, few abdomen crymodynia, palace is cold infertile, the cards such as the muscles and bones impotence caused by kidney deficiency and liver is soft, waist knee crymodynia.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition 1
By cordate houttuynia 25g, kuh-seng 30g, coix seed 40g, Companumoea root 25g, champion bauhinia stem 20g, Psoralea corylifolia 30g, fruit of Cherokee rose 25g, granatum 25g, honeysuckle 35g mixes, and obtains mixture, add determining alcohol be 60% ethanolic solution carry out heating and refluxing extraction 2 times, each refluxing extraction 3h, the amount that the mixture of every 1kg adds ethanolic solution is 4L, and the extract of acquisition merges and filters, by Radix Glycyrrhizae 15g, wilsonii 40g, root of kudzu vine 25g, rainbow conk 15g, cape jasmine 40g, the membrane of a chicken's gizzard 30g, golden cypress 60g, dandelion 50g, Selaginella tamariscina 20g, sealwort 25g, eclipta 30g, semen astragali complanati 25g, pipewort 20g, stringy stonecrop 15g, motherwort 25g and Morinda officinalis 20g mixes, and obtains mixture, adds water and decoct, decoct 3 times, decoct 3h at every turn, the amount of the mixture interpolation water of every 1kg is 3L, decoction liquor merges, and filters, and relative density when filtrate is concentrated into 80 DEG C is 1.30, obtain concentrate, the extract after the filtration obtained above is joined in the concentrate of acquisition, stirs, leave standstill 24h, reclaim ethanol and concentrate, being condensed into thick paste, dry, pulverize into fine powder, obtain Chinese medicine composition 1.
Embodiment 2 Chinese medicine composition 2
By cordate houttuynia 20g, kuh-seng 25g, coix seed 35g, Companumoea root 20g, champion bauhinia stem 15g, Psoralea corylifolia 25g, fruit of Cherokee rose 20g, granatum 20g, honeysuckle 30g mixes, and obtains mixture, add determining alcohol be 60% ethanolic solution carry out heating and refluxing extraction 2 times, each refluxing extraction 3h, the amount that the mixture of every 1kg adds ethanolic solution is 4L, and the extract of acquisition merges and filters, by Radix Glycyrrhizae 10g, wilsonii 35g, root of kudzu vine 20g, rainbow conk 10g, cape jasmine 35g, the membrane of a chicken's gizzard 25g, golden cypress 55g, dandelion 45g, Selaginella tamariscina 15g, sealwort 20g, eclipta 25g, semen astragali complanati 20g, pipewort 15g, stringy stonecrop 10g, motherwort 20g and Morinda officinalis 15g mixes, and obtains mixture, adds water and decoct, decoct 3 times, decoct 3h at every turn, the amount of the mixture interpolation water of every 1kg is 3L, decoction liquor merges, and filters, and relative density when filtrate is concentrated into 80 DEG C is 1.30, obtain concentrate, the extract after the filtration obtained above is joined in the concentrate of acquisition, stirs, leave standstill 24h, reclaim ethanol and concentrate, being condensed into thick paste, dry, pulverize into fine powder, obtain Chinese medicine composition 2.
Embodiment 3 Chinese medicine composition 3
By cordate houttuynia 30g, kuh-seng 35g, coix seed 45g, Companumoea root 30g, champion bauhinia stem 25g, Psoralea corylifolia 35g, fruit of Cherokee rose 30g, granatum 30g, honeysuckle 40g mixes, and obtains mixture, add determining alcohol be 60% ethanolic solution carry out heating and refluxing extraction 2 times, each refluxing extraction 3h, the amount that the mixture of every 1kg adds ethanolic solution is 4L, and the extract of acquisition merges and filters, by Radix Glycyrrhizae 20g, wilsonii 45g, root of kudzu vine 30g, rainbow conk 20g, cape jasmine 45g, the membrane of a chicken's gizzard 35g, golden cypress 65g, dandelion 55g, Selaginella tamariscina 25g, sealwort 30g, eclipta 35g, semen astragali complanati 30g, pipewort 25g, stringy stonecrop 20g, motherwort 30g and Morinda officinalis 25g mixes, and obtains mixture, adds water and decoct, decoct 3 times, decoct 3h at every turn, the amount of the mixture interpolation water of every 1kg is 3L, decoction liquor merges, and filters, and relative density when filtrate is concentrated into 80 DEG C is 1.30, obtain concentrate, the extract after the filtration obtained above is joined in the concentrate of acquisition, stirs, leave standstill 24h, reclaim ethanol and concentrate, being condensed into thick paste, dry, pulverize into fine powder, obtain Chinese medicine composition 3.
Embodiment 4 toxicology test
Embodiment 4 toxicology test
Acute toxicity test
Property experimental observation, because measuring LD
50, therefore carried out the mensuration of maximum dosage-feeding.Chinese medicine composition prepared by embodiment 1 is dissolved in distilled water, be configured to solution gavage mouse, result shows, with the maximum administration concentration 11.11g crude drug/ml of medicine, maximum administration volume 40ml/kg was administered twice to mouse stomach in 24 hours, mouse maximum dosage-feeding is 888.8g crude drug/kg, and bad reaction and death do not appear in animal.The each internal organs no abnormality seen of anatomic observation.
Long term toxicity test
This test application SD rat 80, Chinese medicine composition prepared by embodiment 1 is dissolved in distilled water, is configured to solution gavage, if control group and 14.5g, 29g, 58g crude drug/kg dosage group, continuous gastric infusion 4 weeks, observes the impact of Chinese medicine composition of the present invention on animal indices.Result of the test shows, successive administration 4 weeks, and the body weight, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index etc. of Chinese medicine composition of the present invention to rat all have no significant effect; Blood biochemical ten binomial index determining result, administration 4 weeks low dose group BiLi values, may with wherein three serum sample haemolysis be relevant higher than control group (P < 0.05); Low dose group, middle dosage group TP value are higher than control group (P < 0.05), but all within normal physiologic range, other index compares no significant difference with control group.Convalescence each administration group indices measured value no significant difference more equal to control group.Each group of each internal organs gross examination of skeletal muscle no abnormality seen.
Embodiment 5 feed
Get wheat 7kg, rice bran 1.5kg, dish dregs of rice 1.2kg, fish meal 0.7kg, calcium monohydrogen phosphate 0.1kg, salt 0.1kg, B B-complex 0.3kg, composite trace element 0.15kg pulverizes, then the raw material after pulverizing is put into mixer to mix, the Chinese medicine composition additive 1.0kg adding embodiment 1 preparation subsequently mixes further, mixed material enters modulator, refining temperature is 70 DEG C, modulating time 10 seconds, after modulation, send into slaking tank and carry out slaking, curing time is 5 minutes, curing temperature 70 DEG C, finally enter pellet fabrication device to granulate, obtain finished product feedstuff.
Embodiment 6 result for the treatment of is tested
Main agents and culture medium
Gram stain, maconkey agar culture medium, Yihong-methylene blue agar medium, nutrient agar, triple sugar iron agar cultivation, SS agar medium (purchased from Beijing extensive and profound in meaning star biotechnology Co., Ltd), broth medium (purchased from Qingdao GaoKeYuan Hai Bo Bioisystech Co., Ltd), sheep blood flat board (purchased from by Hangzhou microorganism reagent Co., Ltd).
Medicine
Feed prepared by embodiment 4
Enrofloxacin injection, specification: 100mL:10g, Pulaike Biological Engineering Co., Ltd.'s fabricated material medicine also provides (content is 99.1% of labelled amount after testing).
Clinical manifestation
Choose the piglet in newborn piglet ~ 30 age in days generation diarrhoea 1 ~ 3 day, sick pig faces that to examine performance as follows: with the row of diarrhoea yellow, white or canescence pasty state loose stool for main clinical characteristics.
The yellow ight soil of draining sample, smell is smelt as of rotten fish, and anus is seriously loose, and defecation incontinence, stains afterbody, perineum and rear leg, and anus becomes red with private parts, lassitude, anorexia, becomes thin, and by symptoms such as Mao Songluan, suffers from diarrhoea suspected of Escherichia coli characteristic of disease.
Sample collection
The aseptic fresh excreta taking diarrhoea piglet, loads sterilizing test tubes, preserves, adopt its liver, spleen, lymphonodi mesenterici, heart, send laboratory back to be checked in 3h for sick dead pig is then aseptic in ice bath.
Laboratory diagnosis
Bacteriology checking
Sample smear, Gram's staining, basis of microscopic observation, be dispersed in as seen or paired, without the straight-bar bacterium of gemma, the blunt circle in two ends, painted feminine gender.
The separation of bacterium is cultivated
By sample distilled water diluting, getting 0.1mL supernatant coats on blood agar plate and ordinary culture medium, after 37 DEG C of constant temperature culture 24h, ordinary flat is selected the typical bacterium colony of form, be inoculated in maconkey agar, triple sugariron, SS agar and eosin methylene blue agar respectively, after 37 DEG C of constant temperature culture 24h, observe cultural character.
Tentative contrast therapy
By face diagnosis and laboratory diagnosis be diagnosed as coliform diarrhea, to 170 diarrhoea piglets of clinical discovery, be divided into different treatment groups to treat at random by the priority of morbidity, the piglet for the treatment of group 1 is 90, feed prepared by the feeding embodiment of the present invention 4, feeding 7 days, treatment group 2 feeding common wheat feed, neck intramuscular injection Pu Laike enrofloxacin injection after ear, 3 times on the 1st, injection volume is 5mg/kg, injects 7 days.
Observation index and curative effect judging standard
Observation index: mental status and the diarrhoea situation of observing piglet after medication.
Curative effect judging standard: point effective, cure and invalid 3 grades.
Effective: after medication 1 ~ 2, ight soil turns thick, and number of times of having loose bowels reduces, and continues medication to the 3rd day, has loose bowels and do not stop.
Cure: medication is after 1 ~ 2 day, and ight soil turns thick, continue medication to the 3rd day, stopping of having loose bowels, ight soil recovers normal.
Invalid: medication is after 3 days, and diarrhoea is still without the person of being clearly better.
Cure rate=healing piglet number/this pig medication piglet number × 100%;
Efficient=effective piglet number/this pig medication piglet number × 100%.
Laboratory diagnosis
Liver contact basis of microscopic observation, sees the brevibacterium of the Gram-negative be dispersed in; Growing state on differential medium is in table 1.
Table 1 is for the growing state of examination bacterium on various culture medium
| Culture medium | Cultural character |
| Sheep blood agar | There is β zone of hemolysis |
| Maconkey agar | Circle, flat, the red colonies that center is deeply pink |
| Triple sugariron | Produce acid gas bottom triple sugariron, inclined-plane turns yellow, H 2S is negative |
| SS agar | Red colonies |
| Yihong-methylene blue agar | The circular colonies of atropurpureus band metallic luster |
Escherichia coli are defined as in conjunction with Gram's staining result and the growing state on differential medium.
Efficacy result compares, and the results are shown in Table 2.
Table 2 efficacy result compares
| Group | Treatment head number | Cure number | Cure rate (%) | Significant figure (%) |
| Treatment group 1 | 90 | 82 | 91.1 | 100 |
| Treatment group 2 | 80 | 61 | 76.3 | 95.3 |
As can be seen from Table 2, Chinese medicine composition provided by the invention is adopted to have significant curative effect in treatment coliform diarrhea in piglets.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (5)
1. be used for the treatment of a feed for coliform diarrhea in piglets, it is characterized in that: its raw material comprises wheat, rice bran, the dish dregs of rice, fish meal, calcium monohydrogen phosphate, salt, B B-complex, composite trace element and is used for the treatment of the Chinese medicine composition additive of coliform diarrhea in piglets;
In described feed, the weight of each raw material is respectively wheat 6kg ~ 8kg, rice bran 1kg ~ 2kg, dish dregs of rice 1.0kg ~ 1.2kg, fish meal 0.6kg ~ 0.8kg, calcium monohydrogen phosphate 0.05kg ~ 0.15kg, salt 0.05kg ~ 0.15kg, B B-complex 0.2kg ~ 0.4kg, composite trace element 0.1kg ~ 0.2kg, described Chinese medicine composition additive 0.8kg ~ 1.2kg;
The bulk drug of described Chinese medicine composition additive comprises Radix Glycyrrhizae, cordate houttuynia, kuh-seng, wilsonii, the root of kudzu vine, coix seed, rainbow conk, cape jasmine, the membrane of a chicken's gizzard, golden cypress, dandelion, Selaginella tamariscina, sealwort, eclipta, Companumoea root, champion bauhinia stem, semen astragali complanati, Psoralea corylifolia, the fruit of Cherokee rose, granatum, honeysuckle, pipewort, stringy stonecrop, motherwort and Morinda officinalis;
In described Chinese medicine composition, the weight of each bulk drug is respectively Radix Glycyrrhizae 10g ~ 20g, cordate houttuynia 20g ~ 30g, kuh-seng 25g ~ 35g, wilsonii 35g ~ 45g, root of kudzu vine 20g ~ 30g, coix seed 35g ~ 45g, rainbow conk 10g ~ 20g, cape jasmine 35g ~ 45g, the membrane of a chicken's gizzard 25g ~ 35g, golden cypress 55g ~ 65g, dandelion 45g ~ 55g, Selaginella tamariscina 15g ~ 25g, sealwort 20g ~ 30g, eclipta 25g ~ 35g, Companumoea root 20g ~ 30g, champion bauhinia stem 15g ~ 25g, semen astragali complanati 20g ~ 30g, Psoralea corylifolia 25g ~ 35g, fruit of Cherokee rose 20g ~ 30g, granatum 20g ~ 30g, honeysuckle 30g ~ 40g, pipewort 15g ~ 25g, stringy stonecrop 10g ~ 20g, motherwort 20g ~ 30g and Morinda officinalis 15g ~ 25g.
2. feed as claimed in claim 1, is characterized in that: in described feed, the weight of each raw material is respectively wheat 7kg, rice bran 1.5kg, dish dregs of rice 1.2kg, fish meal 0.7kg, calcium monohydrogen phosphate 0.1kg, salt 0.1kg, B B-complex 0.3kg, composite trace element 0.15kg, described Chinese medicine composition additive 1.0kg.
3. be used for the treatment of a Chinese medicine composition for coliform diarrhea in piglets, it is characterized in that: bulk drug is made up of Radix Glycyrrhizae, cordate houttuynia, kuh-seng, wilsonii, the root of kudzu vine, coix seed, rainbow conk, cape jasmine, the membrane of a chicken's gizzard, golden cypress, dandelion, Selaginella tamariscina, sealwort, eclipta, Companumoea root, champion bauhinia stem, semen astragali complanati, Psoralea corylifolia, the fruit of Cherokee rose, granatum, honeysuckle, pipewort, stringy stonecrop, motherwort and Morinda officinalis;
In described Chinese medicine composition, the weight of each bulk drug is respectively Radix Glycyrrhizae 10g ~ 20g, cordate houttuynia 20g ~ 30g, kuh-seng 25g ~ 35g, wilsonii 35g ~ 45g, root of kudzu vine 20g ~ 30g, coix seed 35g ~ 45g, rainbow conk 10g ~ 20g, cape jasmine 35g ~ 45g, the membrane of a chicken's gizzard 25g ~ 35g, golden cypress 55g ~ 65g, dandelion 45g ~ 55g, Selaginella tamariscina 15g ~ 25g, sealwort 20g ~ 30g, eclipta 25g ~ 35g, Companumoea root 20g ~ 30g, champion bauhinia stem 15g ~ 25g, semen astragali complanati 20g ~ 30g, Psoralea corylifolia 25g ~ 35g, fruit of Cherokee rose 20g ~ 30g, granatum 20g ~ 30g, honeysuckle 30g ~ 40g, pipewort 15g ~ 25g, stringy stonecrop 10g ~ 20g, motherwort 20g ~ 30g and Morinda officinalis 15g ~ 25g.
4. the preparation method of Chinese medicine composition described in claim 3, is characterized in that:
The first step, cordate houttuynia, kuh-seng, coix seed, Companumoea root, champion bauhinia stem, Psoralea corylifolia, the fruit of Cherokee rose, granatum and honeysuckle are mixed by weight, obtain mixture, add determining alcohol be 50% ~ 70% ethanolic solution carry out heating and refluxing extraction 2 times, each refluxing extraction 2h ~ 3h, the amount of the mixture interpolation ethanolic solution of every 1kg is 3L ~ 5L, and the extract of acquisition merges and filters;
Second step, remaining bulk drug component is mixed by weight, obtain mixture, add water and decoct, decoct 3 times, each decoction 2h ~ 3h, the amount of the mixture interpolation water of every 1kg is 2L ~ 4L, and decoction liquor merges, and filters, relative density when filtrate is concentrated into 70 ~ 90 DEG C is 1.25 ~ 1.30, obtains concentrate;
3rd step, joins the extract of first step gained in the concentrate of second step acquisition, stirs, and leaves standstill 24h, reclaims ethanol and concentrates, being condensed into thick paste, dry, pulverize into fine powder, acquisition Chinese medicine composition.
5. the preparation method of feed described in claim 1, is characterized in that:
The first step, prepares described Chinese medicine composition additive according to preparation method according to claim 4;
Second step, each raw material got except described Chinese medicine composition additive in described feed is first pulverized, and then the raw material after pulverizing is put into mixer and mixes, add Chinese medicine composition additive prepared by the first step again to mix further, mixed material enters modulator, and refining temperature is 70 DEG C, modulating time 10 seconds, after modulation, send into slaking tank and carry out slaking, the curing time is 5 minutes, curing temperature 70 DEG C, finally enter pellet fabrication device to granulate, obtain finished product feedstuff.
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| CN104171377A (en) * | 2014-07-10 | 2014-12-03 | 南宁荣港生物科技有限公司 | Traditional Chinese medicine synbiotic feed additive capable of preventing and treating diarrhea of piglest and preparation method of traditional Chinese medicine synbiotic feed additive capable of preventing and treating diarrhea of piglets |
| CN104256096A (en) * | 2014-10-08 | 2015-01-07 | 青岛农业大学 | Feed additive and feed for treating piglet diarrhea |
| CN104839091B (en) * | 2015-05-28 | 2017-03-01 | 安顺市西秀区春实绿化苗木有限公司 | The cultural method of one boar |
| CN106036219A (en) * | 2016-06-16 | 2016-10-26 | 刘华武 | Feed additive for silver carp |
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| CN106721044A (en) * | 2017-03-06 | 2017-05-31 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention colibacillosis of pigs |
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| CN108743693A (en) * | 2018-08-28 | 2018-11-06 | 江苏农牧科技职业学院 | A kind of piglet health care growth promotion Chinese medicine composition, preparation method and applications |
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| CN102669476A (en) * | 2012-06-05 | 2012-09-19 | 湖南海大生物饲料有限公司 | Wholewheat feed for medium and large pigs |
| CN102870985A (en) * | 2012-09-16 | 2013-01-16 | 湖南恒农生态农业发展有限公司 | Feed for breast-fed sows and preparation method thereof |
| CN103405536A (en) * | 2013-08-14 | 2013-11-27 | 北京元亨神农科技发展有限公司 | Chinese herbal veterinary drug used for treating diarrhoea and preparation method thereof |
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