CN104082529B - For preventing and treating the feed of piglet yellow-white dysentery - Google Patents
For preventing and treating the feed of piglet yellow-white dysentery Download PDFInfo
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Abstract
The invention provides a kind ofly for preventing and treating the feed of piglet yellow-white dysentery, it is characterized in that: raw material comprises corn, dregs of beans, salt, fish meal, soya-bean oil, amino acid additive, vitamin(e) supplement, for preventing and treating the Chinese medicine composition additive of piglet yellow-white dysentery. During this Chinese medicine composition additive can have bacteriogenic endotoxin and exotoxin and destruction, strengthen the defense function of body, strengthen bacterium phagocytosis, promote lymphocytic conversion, improve the resistance infection of body, thereby control piglet yellow-white dysentery, meanwhile, improve digestive function, promote appetite, build up health, drug residue is low, toxic and side effect is little, be difficult for producing drug resistance.
Description
Technical field
The present invention relates to field of feed, relate in particular to a kind of for preventing and treating the feed of piglet yellow-white dysentery.
Background technology
Piglet yellow-white dysentery is one of modal disease of pig being caused by pathogenic Escherichia coli, is generally divided into2 kinds of piglet yellow scour and the white scours of piglet. Piglet yellow scour has another name called newborn piglet colibacillosis, multiple being born inSeveral hours piglets to 1 week age after birth, 1～3 age in days is the most common, is acutely to suffer from diarrhoea, discharge HuangLook or yellow-white watery stools, and dehydration death is the acute height lethal of the one enteron aisle of feature rapidlyInfectious disease. The white scour of piglet is the multiple a kind of acute infectious intestinal disease of the piglet of 10～30 ages in days, clinicalUpper taking diarrhea or discharge milky, yellowish white or canescence with the sticky ight soil of special fishy odor asFeature, the incidence of disease is high, and the death rate is low; But it is slow to survive dead piglet growth, price of deed rateReduce, cause larger economic loss.
For many years, antibiotic and chemotherapeutic agent are the effect a permanent cure common drugs of disease of immuning failure rear defence, andGet good effect. But antibacterials are used for a long time and widely, especially unreasonable abuse, lures intoThere is resistance phenomenon in pathogenic bacteria, causes many antibacterials to exist to the curative effect of coliform diarrhea in pigletsConstantly reduce, how to develop high-efficiency low-toxicity, it is large that the medicine of low-residual, low drug resistance has become control pigletThe enterobacteria property problem in the urgent need to address of suffering from diarrhoea.
Since the eighties in 20th century, because Chinese herbal medicine does not produce drug resistance, there is again certain resistingBacterium effect, also meets green cultivation theory, and people more and more pay attention to its application aspect swine disease. Medium-height grassThat medical instrument has is antibacterial, antiviral, improve many-sided functions such as immunity, and Chinese medicine be difficult for producing drug resistance andMedicament residue, toxic and side effect is also little, but also can eliminate medicament residue in use of antibiotic andThe negative effects such as drug resistance, also have neutralization and destruction, energy to bacteriogenic endotoxin, exotoxinSignificantly strengthen the defense function of body, improve digestive function, build up health.
The present invention, taking theory of traditional Chinese medical science as basis, proposes a kind of for preventing and treating the feed of piglet yellow-white dysentery, its bagContaining Chinese medicine additive component, during it has bacteriogenic endotoxin and exotoxin and destruction, can increaseThe defense function of strong body, strengthens bacterium phagocytosis, promotes lymphocytic conversion, raising bodyResistance infection, improves digestive function, promotes appetite, builds up health, and drug residue is low, toxic and side effectLittle, the difficult drug resistance that produces.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of for preventing and treating the Chinese traditional medicine composition of piglet yellow-white dysenteryThing additive and the feed that comprises this Chinese medicine composition additive, this Chinese medicine composition additive can be to carefullyDuring the endotoxin that bacterium produces and exotoxin have and destruction, strengthen the defense function of body, strengthen bacteriumPhagocytosis, promotes lymphocytic conversion, improves the resistance infection of body, thus control piglet yellow-whiteDysentery, meanwhile, improves digestive function, promotes appetite, builds up health, and drug residue is low, toxic and side effectLittle, the difficult drug resistance that produces.
For solving the problems of the technologies described above, the invention provides a kind of for preventing and treating the feed of piglet yellow-white dysentery, itsRaw material comprise corn, dregs of beans, salt, fish meal, soya-bean oil, amino acid additive, vitamin(e) supplement,For preventing and treating the Chinese medicine composition additive of piglet yellow-white dysentery.
Wherein, the weight portion of described each raw material is respectively corn 280 weight portion～320 weight portions, dregs of beans140 weight portion～160 weight portions, salt 3 weight portion～5 weight portions, fish meal 30 weight portion～40 weightsMeasure part, soya-bean oil 20 weight portion～30 weight portions, amino acid additive 1 weight portion～3 weight portion, support one's familyElement additive 1 weight portion～3 weight portion, Chinese medicine composition additive 40 weight portion～60 weight portions.
Wherein, the bulk drug of described Chinese medicine composition additive comprise faenum graecum, in one's early teens, dandelion,Cordate houttuynia, the coptis, Gorgon fruit, asparagus fern, Chinese ephedra, play both sides of the street, radix bupleuri, the dried immature fruit of citron orange, potentilla discolor, white wine grass,Bark of ash, Samson St Johswort, the root of herbaceous peony, parasitic loranthus, franzenbach rhubarb root and rhizome, galangal, Japanese cryptotaenia stem and leaf, caulis lonicerae, cortex acanthopanacis,Rabdosia amethystoides, kalimeris, reticulate millettia, Chinese yam and American Ginseng.
Wherein, described amino acid additive comprises serine, glutamic acid, glycine, isoleucine, brightThe various conventional amino acid such as propylhomoserin, alanine, proline, also can adopt amino acid premix.
Wherein, described vitamin(e) supplement comprise riboflavin, vitamin C, vitamin E, vitamin A,The various conventional vitamin such as Cobastab, also can adopt vitamin premix.
Wherein, in described Chinese medicine composition additive, the weight portion of each bulk drug is respectively faenum graecum 25 weightPart～35 weight portions, 15 weight portion～25 weight portions, dandelion 60 weight portion～70 weight in one's early teensPart, cordate houttuynia 30 weight portion～40 weight portions, the coptis 35 weight portion～45 weight portions, Gorgon fruit 25 weightsAmount part～35 weight portions, asparagus fern 30 weight portion～40 weight portions, Chinese ephedra 20 weight portion～30 weight portions,Play both sides of the street 15 weight portion～25 weight portions, radix bupleuri 15 weight portion～25 weight portions, the dried immature fruit of citron orange 20 weight portions～30 weight portions, potentilla discolor 15 weight portion～25 weight portions, white wine grass 25 weight portion～35 weight portions,Bark of ash 20 weight portion～30 weight portions, Samson St Johswort 25 weight portion～35 weight portions, the root of herbaceous peony 30 weight portions～40 weight portions, parasitic loranthus 25 weight portion～35 weight portions, franzenbach rhubarb root and rhizome 20 weight portion～30 weight portions,Galangal 20 weight portion～30 weight portions, Japanese cryptotaenia stem and leaf 20 weight portion～30 weight portions, caulis lonicerae 25 weightsAmount part～35 weight portions, cortex acanthopanacis 30 weight portion～40 weight portions, Rabdosia amethystoides 25 weight portion～35 weightsAmount part, kalimeris 15 weight portion～25 weight portions, reticulate millettia 35 weight portion～45 weight portions, Chinese yam 40Weight portion～50 weight portion and American Ginseng 35 weight portion～45 weight portions.
The present invention also provides the preparation method of above-mentioned feed, is specially:
The first step, mixes the each raw material components in Chinese medicine composition additive every 100g by weightMixture, adds the water of 500g～600g, boils 3～4 hours, filters, and obtains the first filtrate, filterSlag adds the water of 200g～300g again, again boils 1～2 hour, filters, and obtains the second filtrate,The first filtrate and the second filtrate are mixed, and the concentrated aqueous solvent of removing, pulverizes, dry, obtains Chinese traditional medicine compositionThing additive;
Second step, adds the described Chinese medicine composition of other raw material components in feedstuff and first step acquisitionAdd agent and put into together fodder mixing machine, continuous uniform stirred after 1～3 hour, put into pulverizer and carried outPulverize, obtain feed.
It is a kind of for preventing and treating the Chinese medicine composition additive of piglet yellow-white dysentery, its raw material that the present invention also providesCartridge bag draw together faenum graecum, in one's early teens, dandelion, cordate houttuynia, the coptis, Gorgon fruit, asparagus fern, Chinese ephedra, Lu LuLogical, radix bupleuri, the dried immature fruit of citron orange, potentilla discolor, white wine grass, bark of ash, Samson St Johswort, the root of herbaceous peony, parasitic loranthus, franzenbach rhubarb root and rhizome,Galangal, Japanese cryptotaenia stem and leaf, caulis lonicerae, cortex acanthopanacis, Rabdosia amethystoides, kalimeris, reticulate millettia, Chinese yam and American Ginseng.
Wherein, in described Chinese medicine composition additive, the weight portion of each bulk drug is respectively faenum graecum 25 weightPart～35 weight portions, 15 weight portion～25 weight portions, dandelion 60 weight portion～70 weight in one's early teensPart, cordate houttuynia 30 weight portion～40 weight portions, the coptis 35 weight portion～45 weight portions, Gorgon fruit 25 weightsAmount part～35 weight portions, asparagus fern 30 weight portion～40 weight portions, Chinese ephedra 20 weight portion～30 weight portions,Play both sides of the street 15 weight portion～25 weight portions, radix bupleuri 15 weight portion～25 weight portions, the dried immature fruit of citron orange 20 weight portions～30 weight portions, potentilla discolor 15 weight portion～25 weight portions, white wine grass 25 weight portion～35 weight portions,Bark of ash 20 weight portion～30 weight portions, Samson St Johswort 25 weight portion～35 weight portions, the root of herbaceous peony 30 weight portions～40 weight portions, parasitic loranthus 25 weight portion～35 weight portions, franzenbach rhubarb root and rhizome 20 weight portion～30 weight portions,Galangal 20 weight portion～30 weight portions, Japanese cryptotaenia stem and leaf 20 weight portion～30 weight portions, caulis lonicerae 25 weightsAmount part～35 weight portions, cortex acanthopanacis 30 weight portion～40 weight portions, Rabdosia amethystoides 25 weight portion～35 weightsAmount part, kalimeris 15 weight portion～25 weight portions, reticulate millettia 35 weight portion～45 weight portions, Chinese yam 40Weight portion～50 weight portion and American Ginseng 35 weight portion～45 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition additive, is specially:
Each raw material components is mixed by weight, and every 100g mixture, adds the water of 500g～600g,Boil 3～4 hours, filter, obtain the first filtrate, filter residue adds the water of 200g～300g again, thenInferior boiling 1～2 hour, filters, and obtains the second filtrate, and the first filtrate and the second filtrate are mixed, concentratedRemove aqueous solvent, pulverize, dry, obtain Chinese medicine composition additive.
Beneficial effect of the present invention:
The invention provides a kind of for preventing and treating the Chinese medicine composition additive of piglet yellow-white dysentery and comprising this Chinese medicineThe feed of composition additive, this Chinese medicine composition additive can be to bacteriogenic endotoxin and outer poisonIn have and destruction, strengthen the defense function of body, strengthen bacterium phagocytosis, promote that lymph is thinBorn of the same parents' conversion, improves the resistance infection of body, thereby prevents and treats piglet yellow-white dysentery, meanwhile, improves digestion machineCan, promote appetite, to build up health, drug residue is low, toxic and side effect is little, be difficult for producing drug resistance.
Detailed description of the invention
The invention provides a kind of for preventing and treating the Chinese medicine composition additive of piglet yellow-white dysentery, its bulk drugComprise faenum graecum, in one's early teens, dandelion, cordate houttuynia, the coptis, Gorgon fruit, asparagus fern, Chinese ephedra, play both sides of the street,Radix bupleuri, the dried immature fruit of citron orange, potentilla discolor, white wine grass, bark of ash, Samson St Johswort, the root of herbaceous peony, parasitic loranthus, franzenbach rhubarb root and rhizome, heightGalingal, Japanese cryptotaenia stem and leaf, caulis lonicerae, cortex acanthopanacis, Rabdosia amethystoides, kalimeris, reticulate millettia, Chinese yam and American Ginseng.
Further, described Chinese medicine composition additive is only made up of above-mentioned raw materials medicine.
The pharmacology of each bulk drug is as follows:
Faenum graecum: warm in nature, bitter, has kidney-replenishing, effect of dispellieg cold and dampness cures mainly cold hernia, and the abdomen side of body is swollenFull, the disturbance of lower legs due to pathogenic cold and dampness, the cards such as the soreness of waist, impotence of suffering from a deficiency of the kidney.
In one's early teens: taste is pungent, warm in nature, return spleen, stomach warp, there is effect of eliminating dampness promoting the circulation of qi, warming middle energizer to arrest vomiting,Cure mainly internal retention of cold wetness, abdominal fullness and distention crymodynia, the card such as belch is vomitted contrary, do not feel like eating.
Dandelion: latin name TaraxaciHerba, taste is sweet, bitter, cold in nature, enters liver, stomach warp, hasClearing heat and detoxicating, the carbuncle that disappears dissipating bind, clear liver and improve vision, the effect of inducing diuresis for treating strangurtia, be mainly used in controlling of sore swollen toxinTreat, especially remarkable to acute mastitis effect, also can be used for the treatment of the symptom such as red eye, swell pain of liver-fire flaming, thisAlso there is the effect of promoting urination and removing dampness outward.
Cordate houttuynia: latin name houttuyniaeherba, taste is pungent, and cold nature enters lung, urinary bladder channel, toolHave clearing heat and detoxicating, removing pus and relieving carbuncle, effect of inducing diuresis for treating strangurtia, for lung carbuncle pyemesis, phlegm heat is coughed and is breathed heavily, heat poisonBloody flux, damp-heat gonorrhoea, hot carbuncle carbuncle, snakeworm is wanted first-class card.
The coptis: bitter, cold in nature, enter the heart, lung, courage, stomach, large intestine channel, there is heat-clearing and damp-drying drug, purging intense heat solutionPoison, the effect of cooling blood for improving eyesight, cures mainly damp and hot ruffian full, and vomiting acid regurgitation, rushes down dysentery, jaundice, unconsciousness due to high fever,Heart-fire hyperactivity, dysphoria and insomnia, blood-head is told nosebleed, hot eyes, toothache, quenches one's thirst, the carbuncle furunculosis that swell, eczema, wetsSore, the duct card such as suppurate.
Gorgon fruit: taste is sweet, puckery, property is flat. Return spleen, kidney channel. There is supplementing the kidney to control the nocturnal, tonifying spleen antidiarrheal, clearing dampOnly the function of band, cures mainly emission, splenasthenic diarrhea, and insufficiency of the spleen gonorrhoea, is with inferior card.
Asparagus fern: taste is sweet, bitter, cold in nature, returns lung, kidney channel, has nourishing yin to moisten dryness, effect that clearing lung-heat is promoted the production of body fluid,Cure mainly cough caused by dryness-heat, deficiency of Yin labor is coughed, fire excess from yin deficiency, solid seminal emission, premature ejaculation and the flaring up of deficient fire of kidney essense itAbscess of throat, pyreticosis Tianjin wound is thirsty, the interior heat cards such as the dry constipation of intestines of quenching one's thirst.
Chinese ephedra: pungent, the micro-hardship of taste, warm in nature, enter lung, urinary bladder channel, have and send out cold inducing sweat, freeing lung and relieving asthma,The effect of inducing diuresis for removing edema, is mainly used in the superficies excess syndromes such as the fever without perspiration of catching cold; Rheumatic numbness pain; ColdEvil criminal's lung or accumulation of heat in the lung are to coughing the cards such as contrary, oedema, difficult urination of breathing.
Play both sides of the street: latin name LiquidambarisFructus, bitter, property is flat, returns liver, and kidney channel, hasDispelling, collateral-activating, effect that Li Shui stimulates the menstrual flow, for joint pain, numbness contracture, oedema turgor, the few warp of breastThe card such as close.
Radix bupleuri: latin name bupleuriradix is the dry root of umbelliferae bupleurum, bitter, property is micro-Cold, return liver, gallbladder channel, have to evacuate and bring down a fever, rise relax effect of liver of sun, cure mainly cold, fever, fever and chills are pastCome, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, the card such as uterus comes off, irregular menstruation.
The dried immature fruit of citron orange: bitter, pungent, cold nature, enters spleen, stomach warp, has relieving stagnant Qi to disappear long-pending, and dissolving phlegm removes the effect of ruffian,Be mainly used in stagnant stopping, the Yangming fu-viscera excess card of abdominal fullness and distention, constipation.
Potentilla discolor: sweet, the micro-hardship of taste, property is flat, has the effects such as clearing heat and detoxicating, cooling blood and hemostasis, cures mainlyEnteritis, bacillary dysentery, amoebic dysentery, spits blood, and bleeding from five sense organs or subcutaneous tissue, has blood in stool, leukorrhea, wound is controlled in external applicationWound, carbuncle furuncle poison waits card.
White wine grass: bitter, pungent, cold in nature, there is clearing away heat to and alleviating pain, effect of dispelling pathogenic wind and eliminating phlegm, cures mainly laryngitis,Pneumonia, abscess of throat, the cards such as tonsillitis.
Bark of ash: latin name GentianaeMacrophyllaeRadix, taste is pungent, bitter, and cold nature is returned stomachWarp, Liver Channel, gallbladder channel, have wines used as antirheumatic, relaxing muscles and tendons network, and effect of clearind deficient heat, cures mainly arthralgia due to wind-dampness,The contraction of muscle arteries and veins, joint is ached, afternoon tidal fever, the cards such as infantile malnutrition heating.
Samson St Johswort: bitter, pungent, cold in nature, return liver, the spleen channel, there is removing pattogenic heat from the blood and toxic material from the body, promoting blood circulation for regulating menstruation, dispelsEffect of wind and removing obstruction in channels, cure mainly various hemorrhage, enteritis and dysentery, acute mastitis, the carbuncle serious case of furuncle that swells, scalds, snake bite,Irregular menstruation, dysmenorrhoea, leukorrhea, traumatic injury, arthralgia due to wind-dampness, the cards such as aphtha.
The root of herbaceous peony: latin name PaeoniaeRadixAlba, bitter, acid, cool in nature, enter liver, the spleen channel, toolThere is nourishing blood and liver, slow middle pain relieving, astringe yin is received effect of sweat, cures mainly chest abdomen pain over the hypochondriac region, rushes down dysentery stomachache,Spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, is with inferior card.
Parasitic loranthus: bitter, sweet, property is flat, enters liver, kidney channel, have filling liver kidney, strengthening the bones and muscles, wines used as antirheumatic,The effect of antiabortive unit, for the soreness of waist pain due to kidney deficiency and liver, muscles and bones impotence is soft, the foot and knee being feeble, liver kidneyDeficiency, essence and blood is empty to be lost, the fetal irritability of liability to be abortion, the cards such as waist abdomen pain.
Franzenbach rhubarb root and rhizome: latin name RadixetRhizomeRheiFranzenbachii is polygonaceae plant ripple leafThe root and rhizome of rheum officinale, bitter; Cold in nature, return stomach; Large intestine channel, has the removing toxic substances of purging heat; Cool bloodEffect of the stasis of blood, cures mainly jaundice with damp-heat pathogen; Dysentery; Through closing stomachache; Hematemesis and epistaxis; Fall and beat stasis of blood pain; CarbuncleSwollen serious case of furuncle; The erosion of mucous membrane in the oral cavity; The cards such as burn and scald.
Galangal: taste is pungent, hot in nature, return spleen, stomach warp, there is warming stomach for dispelling cold, effect of the pain relieving that helps digestion.For coldness and pain in the epigastrium, gastrofrigid vomiting, the cards such as belch acid regurgitation.
Japanese cryptotaenia stem and leaf: taste is pungent, hardship; Property is put down, and has dispelling wind stopping cough; Eliminating damp, detoxifying; Effect of blood-activating analgetic,Cure mainly pneumonia, pulmonary abscess, gonorrhoea, hernia, acute toothache, ulcer malignant boil is swollen, herpes zoster, skin scabiesThe card such as itch.
Caulis lonicerae: taste is sweet, cold in nature, attach to the lung and stomach meridians, have clearing heat and detoxicating, effect of dispelling wind dredging collateral,Cure mainly warm disease heating, toxic-heat and blood stasis, the carbuncle sore that swell, rheumatic fever numbness, card such as redness and swelling of joints heat pain grade.
Cortex acanthopanacis: be the root skin of studies on plants of Acanthopanax Miq. in Araliaceae acanthopanax gracilistylus and Panax sessiliflorus, taste is pungent, bitter,Warm in nature, return liver, kidney, there is wines used as antirheumatic; Filling liver kidney; Strengthening the bones and muscles; Invigorate blood circulation effect of arteries and veins, cures mainlyWind-cold-dampness arthralgia; Lumbocrural pain; Muscles and bones impotence is soft; Children's's retardation of walking; Body void is frail; Traumatic injury; BoneFolding; Oedema; Beriberi; The uncontrolled urination card such as itch.
Rabdosia amethystoides: bitter, pungent, gas perfume (or spice), cool in nature, the thoughts of returning home, liver, the spleen channel, have clearing heat and promoting diuresis, livesEffect of blood removing toxic substances, cures mainly jaundice with damp-heat pathogen, stranguria, and oedema, abscess of throat, joint pain, amenorrhoea,Acute mastitis, hemorrhoid, traumatic injury, the cards such as venomous snake bite.
Kalimeris: taste is pungent, cool in nature, return lung, liver, stomach, large intestine channel, there is clearing heat and cooling blood, eliminating damp, detoxifyingEffect, cure mainly multiple hemorrhage, dysentery, jaundice, oedema stranguria with turbid discharge, cough, acute mastitis hemorrhoid, carbuncle is swollen redPoison, the cards such as snake bite.
Reticulate millettia: latin name spatholobicaulis, bitter, sweet, warm in nature, return liver, kidney channel, haveHemangiectasis, enriches blood and invigorates blood circulation, menstruation regulating, and the effect of stimulating the circulation of the blood and cause the muscles and joints to relax, curing mainly the deficiency of blood has the irregular menstruation of silt,Limbs pain is meciless, the cards such as soreness and weakness of waist and knees, pain.
Chinese yam: latin name dioscoreaerhizoma, taste is sweet, and property is flat, enters lung, spleen, kidney channel, hasStrengthening the spleen and tonifying the lung, beneficial stomach kidney tonifying, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, strengthening the bones and muscles, grow will calm the nerves,The effect of promoting longevity, cures mainly weakness of the spleen and the stomach, lassitude, poor appetite, chronic diarrhea and dysentery, Lung Qi deficiencyDry, asthma due to excessive phlegm cough, kidney qi loss, soreness and weakness of waist and knees, lower limb impotence are weak, the frequent micturition of quenching one's thirst, seminal emission premature ejaculation, bandThe red card such as swollen, fat of lower gonorrhoea, skin.
American Ginseng: sweet, the micro-hardship of taste, cool in nature, the thoughts of returning home, lung, kidney channel, have boosting qi and nourishing yin, and heat-clearing is rawThe effect in Tianjin, cures mainly the deficiency of vital energy thanks to cloudy, and interior heat, coughs and breathe heavily phlegm blood, and abnormal heat is tired tired, quench one's thirst, and dryness of the mouth and throat.
In described Chinese medicine composition additive the weight portion of each bulk drug be respectively faenum graecum 25 weight portions～35 weight portions, in one's early teens 15 weight portion～25 weight portions, dandelion 60 weight portion～70 weight portions,Cordate houttuynia 30 weight portion～40 weight portions, the coptis 35 weight portion～45 weight portions, Gorgon fruit 25 weight portions～35 weight portions, asparagus fern 30 weight portion～40 weight portions, Chinese ephedra 20 weight portion～30 weight portions, Lu LuLogical 15 weight portion～25 weight portions, radix bupleuri 15 weight portion～25 weight portions, the dried immature fruit of citron orange 20 weight portion～30Weight portion, potentilla discolor 15 weight portion～25 weight portions, white wine grass 25 weight portion～35 weight portions, bark of ash20 weight portion～30 weight portions, Samson St Johswort 25 weight portion～35 weight portions, the root of herbaceous peony 30 weight portion～40Weight portion, parasitic loranthus 25 weight portion～35 weight portions, franzenbach rhubarb root and rhizome 20 weight portion～30 weight portions, Gao LiangGinger 20 weight portion～30 weight portions, Japanese cryptotaenia stem and leaf 20 weight portion～30 weight portions, caulis lonicerae 25 weight portions～35 weight portions, cortex acanthopanacis 30 weight portion～40 weight portions, Rabdosia amethystoides 25 weight portion～35 weight portions,Kalimeris 15 weight portion～25 weight portions, reticulate millettia 35 weight portion～45 weight portions, Chinese yam 40 weight portions～50 weight portions and American Ginseng 35 weight portion～45 weight portions.
Further preferably, in described Chinese medicine composition additive, the weight portion of each bulk drug is respectively faenum graecum28 weight portion～32 weight portions, in one's early teens 18 weight portion～22 weight portions, dandelion 63 weight portions～67 weight portions, cordate houttuynia 33 weight portion～37 weight portions, the coptis 38 weight portion～42 weight portions, Gorgon euryaleReal 28 weight portion～32 weight portions, asparagus fern 33 weight portion～37 weight portions, Chinese ephedra 23 weight portion～27Weight portion, 18 weight portion～22 weight portions that play both sides of the street, radix bupleuri 18 weight portion～22 weight portions, the dried immature fruit of citron orange23 weight portion～27 weight portions, potentilla discolor 18 weight portion～22 weight portions, white wine grass 28 weight portions～32 weight portions, bark of ash 23 weight portion～27 weight portions, Samson St Johswort 28 weight portion～32 weight portions, whiteChinese herbaceous peony 33 weight portion～37 weight portions, parasitic loranthus 28 weight portion～32 weight portions, franzenbach rhubarb root and rhizome 23 weight portions～27 weight portions, galangal 23 weight portion～27 weight portions, Japanese cryptotaenia stem and leaf 23 weight portion～27 weight portions,Caulis lonicerae 28 weight portion～32 weight portions, cortex acanthopanacis 33 weight portion～37 weight portions, Rabdosia amethystoides 28 weightsAmount part～32 weight portions, kalimeris 18 weight portion～22 weight portions, reticulate millettia 38 weight portion～42 weightPart, Chinese yam 43 weight portion～47 weight portions and American Ginseng 38 weight portion～42 weight portions.
Have most choosing, in described Chinese medicine composition additive, the weight portion of each bulk drug is respectively faenum graecum 30Weight portion, 20 weight portions, dandelion 65 weight portions, cordate houttuynia 35 weight portions, the coptis 40 in one's early teensWeight portion, Gorgon fruit 30 weight portions, asparagus fern 35 weight portions, Chinese ephedra 25 weight portions, 20 weight play both sides of the streetPart, radix bupleuri 20 weight portions, the dried immature fruit of citron orange 25 weight portions, potentilla discolor 20 weight portions, white wine grass 30 weight portions,Bark of ash 25 weight portions, Samson St Johswort 30 weight portions, the root of herbaceous peony 35 weight portions, parasitic loranthus 30 weight portions, mountainRheum officinale 25 weight portions, galangal 25 weight portions, Japanese cryptotaenia stem and leaf 25 weight portions, caulis lonicerae 30 weight portions,Cortex acanthopanacis 35 weight portions, Rabdosia amethystoides 30 weight portions, kalimeris 20 weight portions, reticulate millettia 40 weight portions,Chinese yam 45 weight portions and American Ginseng 40 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition additive, is specially:
Each raw material components is mixed by weight, and every 100g mixture, adds the water of 500g～600g,Boil 3～4 hours, filter, obtain the first filtrate, filter residue adds the water of 200g～300g again, thenInferior boiling 1～2 hour, filters, and obtains the second filtrate, and the first filtrate and the second filtrate are mixed, concentratedRemove aqueous solvent, pulverize, dry, obtain Chinese medicine composition additive.
It is a kind of for preventing and treating the feed of yellow hundred dysentery of piglet that the present invention also provides, and its raw material comprises corn, beansThe dregs of rice, salt, fish meal, soya-bean oil, amino acid additive, vitamin(e) supplement, Chinese medicine composition additive.
Amino acid additive comprises serine, glutamic acid, glycine, isoleucine, leucine, the third ammoniaThe various conventional amino acid such as acid, proline, also can adopt amino acid premix, as above sea cowry energy chemical industryThe composite aminophenol powder that Co., Ltd produces.
Vitamin(e) supplement comprises riboflavin, vitamin C, vitamin E, vitamin A, CobastabEtc. various conventional vitamin, also can adopt vitamin premix, it is limited that profit as excellent in Beijing is protected biotechnologyThe excellent dimension element that company produces.
In described feed, the weight portion of each raw material is respectively corn 280 weight portion～320 weight portions, dregs of beans140 weight portion～160 weight portions, salt 3 weight portion～5 weight portions, fish meal 30 weight portion～40 weightsMeasure part, soya-bean oil 20 weight portion～30 weight portions, amino acid additive 1 weight portion～3 weight portion, support one's familyElement additive 1 weight portion～3 weight portion, Chinese medicine composition additive 40 weight portion～60 weight portions.
Further, in described feed, the weight portion of each raw material is respectively corn 300 weight portions, dregs of beans 150Weight portion, salt 4 weight portions, fish meal 35 weight portions, soya-bean oil 25 weight portions, amino acid additive 2Weight portion, vitamin(e) supplement 2 weight portions, Chinese medicine composition additive 50 weight portions.
The present invention also provides the preparation method of above-mentioned feed, is specially:
The first step, prepares Chinese medicine composition additive;
Second step, adds the described Chinese medicine composition of other raw material components in feedstuff and first step acquisitionAdd agent and put into together fodder mixing machine, continuous uniform stirred after 1～3 hour, put into pulverizer and carried outPulverize, obtain feed.
Below adopt embodiment to describe embodiments of the present invention in detail, whereby how the present invention is appliedTechnological means solves technical problem, and the implementation procedure of reaching technique effect can fully understand and real according to thisExecute.
Embodiment 1 Chinese medicine composition additive 1
By faenum graecum 30g, 20g, dandelion 65g, cordate houttuynia 35g, coptis 40g, Gorgon fruit in one's early teens30g, asparagus fern 35g, Chinese ephedra 25g, the 20g that plays both sides of the street, radix bupleuri 20g, dried immature fruit of citron orange 25g, potentilla discolor 20g,White wine grass 30g, bark of ash 25g, Samson St Johswort 30g, root of herbaceous peony 35g, parasitic loranthus 30g, franzenbach rhubarb root and rhizome 25g, heightGalingal 25g, Japanese cryptotaenia stem and leaf 25g, caulis lonicerae 30g, cortex acanthopanacis 35g, Rabdosia amethystoides 30g, kalimeris 20g, chickenBlood rattan 40g, Chinese yam 45g and American Ginseng 40g mix, and every 100g mixture adds the water of 500g,Boil 3 hours, filter, obtain the first filtrate, filter residue adds the water of 300g again, again boils 2Hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the concentrated aqueous solvent of removing,Pulverize, dry, obtain Chinese medicine composition additive.
Embodiment 2 Chinese medicine composition additives 2
By faenum graecum 28g, 18g, dandelion 63g, cordate houttuynia 33g, coptis 38g, Gorgon fruit in one's early teens28g, asparagus fern 33g, Chinese ephedra 23g, the 18g that plays both sides of the street, radix bupleuri 18g, dried immature fruit of citron orange 23g, potentilla discolor 18g,White wine grass 28g, bark of ash 23g, Samson St Johswort 28g, root of herbaceous peony 33g, parasitic loranthus 28g, franzenbach rhubarb root and rhizome 23g, heightGalingal 23g, Japanese cryptotaenia stem and leaf 23g, caulis lonicerae 28g, cortex acanthopanacis 33g, Rabdosia amethystoides 28g, kalimeris 18g, chickenBlood rattan 38g, Chinese yam 43g and American Ginseng 38g mix, and every 100g mixture adds the water of 500g,Boil 3 hours, filter, obtain the first filtrate, filter residue adds the water of 300g again, again boils 2Hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the concentrated aqueous solvent of removing,Pulverize, dry, obtain Chinese medicine composition additive.
Embodiment 3 Chinese medicine composition additives 3
By faenum graecum 33g, 22g, dandelion 67g, cordate houttuynia 37g, coptis 42g, Gorgon fruit in one's early teens32g, asparagus fern 37g, Chinese ephedra 27g, the 22g that plays both sides of the street, radix bupleuri 22g, dried immature fruit of citron orange 27g, potentilla discolor 22g,White wine grass 32g, bark of ash 27g, Samson St Johswort 32g, root of herbaceous peony 37g, parasitic loranthus 32g, franzenbach rhubarb root and rhizome 27g, heightGalingal 27g, Japanese cryptotaenia stem and leaf 27g, caulis lonicerae 32g, cortex acanthopanacis 37g, Rabdosia amethystoides 32g, kalimeris 22g, chickenBlood rattan 42g, Chinese yam 47g and American Ginseng 42g mix, and every 100g mixture adds the water of 500g,Boil 3 hours, filter, obtain the first filtrate, filter residue adds the water of 300g again, again boils 2Hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the concentrated aqueous solvent of removing,Pulverize, dry, obtain Chinese medicine composition additive.
Embodiment 4 toxicology tests
Acute toxicity testing
Select 20 of Kunming mouses, female half and half, body weight (20+2) g, in Qingdao City animal used as testThe heart provides, and Chinese medicine composition additive prepared by embodiment 1 is dissolved in distilled water, is prepared into 1g/mlSolution, gavage mouse, through preliminary experiment, fail to detect the LD of oral administration50Therefore, survey its maximumDosis tolerata, with the administration volume of 2.0ml/10g body weight, gavages 2 times/d, and interval 6h gives observation post administration7d, records animal dead and toxicity symptom, when experiment finishes, by all animals processing, dissects,Visually observe each main organs lesion tissue situation, gavage for 2 times after 140g crude drug/kg, animal activity,Feed water inlet does not show any abnormalities, and observes 7d animal dead, and gross necropsy has no the bright of main organs tissueAobvious abnormal.
Long term toxicity test
Select 40 male SD rats, weight (180 ± 20) g, is carried by Qingdao City's Experimental Animal CenterConfession, is divided into 2 groups at random, blank group and Chinese drug-treated group, and 20 every group, blank group is distilledWater, the Chinese medicine composition additive that Chinese drug-treated group is prepared embodiment 1 is dissolved in distilled water, is prepared intoThe solution of 1g/ml, gavages rat, and the amount of gavaging is 50g crude drug/kg, on every Mondays to the morning Saturday gavage giveMedicine 1 time, continuously 180d, administration volume is 2mL/100g body weight, see every day before administration and during administrationExamine rat general state, sign, food ration, drinking-water and ight soil situation. When administration 90d in last administrationAfter 24h, each group extracts 6, male and female half and half; When 180d, after last administration 24h, each group extracts 6,Male and female half and half; After drug withdrawal, 30d respectively organizes and extracts 6, and male and female half and half, with urethane anesthesia, from belly masterArterial blood extracting, each group is all killed and gets animal, checks hematology and blood parameters, gets after blood, amasses wealth by heavy taxation at onceCore, liver,kidney,spleen, lung, adrenal gland, thyroid gland, thymus gland, testis, ovary, uterus, brain,The internal organs such as prostate are weighed, according to weight calculator official weight coefficient and make pathological examination.
On inspection, during successive administration, the activity of animal, body weight, food ration, stool and hair lightPool degree no abnormality seen, it is dead that animal has no, and naked eyes have no obvious pathology, respectively organize the inspection of rat peripheral hemogramLook into all in normal range (NR), the raw tea index of blood is all in normal range (NR), and Chinese drug-treated group Rats Organs and Tissues coefficient is with blankControl group is compared does not have significant difference.
Show through toxicology test, Chinese medicine composition feed addictive provided by the invention is nontoxic.
The preparation of embodiment 5 feeds
By corn 30kg, dregs of beans 15kg, salt 0.4kg, fish meal 3.5kg, soya-bean oil 2.5kg, glutamic acid0.1kg, glycine 0.1kg, vitamin C 0.1kg, vitamin E 0.1kg, embodiment 1 prepare inDrug composition additive 5kg. Put into together fodder mixing machine, continuous uniform stirred after 3 hours, putEnter in pulverizer and pulverize, obtain feed.
Embodiment 6 therapeutic tests
Experimental animal
Test 200 of disease pigs, the kind of pig is DLY three way cross.
Test method
Drug sensitive test: take disease chitling road and ight soil to isolate enteropathogenic E．Coli, make with embodiment 1Standby Chinese medicine composition additive carries out drug sensitive test, is dissolved in distilled water, is configured to 0.2g (formerMaterial medicine)/ml solution simultaneously with Florfenicol, erythromycin, tetracycline, ampicillin, orfloxacin,The antibiotic such as amikacin, gentamicin contrasts.
The solution of Chinese medicine composition additive configuration adopts plate punch method, by autoclaved agar trainingSupport in base 15～20mL impouring sterilizing plate, after it solidifies, pour the bacterium that 0.2mL has proofreaied and correct intoSuspension (107CFU/mL), smoothens with sterile cotton swab. With sterilized Gelose punch (diameter 6mm)At dull and stereotyped equal intervals punching, back cover. Use 1mL sterilizing syringe, Chinese medicine composition additive is configuredSolution orifice in, full without flowing over being as the criterion, builds plate, be placed in 37 DEG C of insulating boxs and cultivate after 24h,Survey its susceptibility antibacterial circle diameter (mm) clearly, average. Criterion: antibacterial circle diameter < 10mmFor resistance; 10～14mm is low responsive; 14～19mm is medium sensitivity; > 19mm is for highly quickSense.
The Kirby-Bauer bacterium that the drug sensitive test of Florfenicol adopts the World Health Organization (WHO) to recommendLiquid rubbing method. On good plain agar flat board, pour the bacterial suspension that 0.2mL has proofreaied and correct into(107CFU/mL), smoothen with sterile cotton swab. Flat board is added a cover placement room temperature and is dried to few 3min, butMust not exceed 15min, with aseptic nipper, drug sensitive test paper is attached on the flat board that coats bacterium liquid to each scraps of paperCenter is at a distance of 24mm at least, and two scraps of paper centers are at a distance of 30mm at least, and plate is placed in 37 DEG C of insulating boxsAfter interior cultivation 24h, measure the diameter (mm comprises that the scraps of paper count) of antibacterial ring, average.The edge of antibacterial ring be can not see bacterium with naked eyes and is obviously grown and be limited. According to standard committee of clinical labororatory of the worldMember's meeting (NationalCommitteeforClinicalLabo-ratoryStandards, NCCLS) pushes awayThe scraps of paper diffusion standard of recommending is carried out the Monitoring of drug resistance of swine Escherichia coli to Florfenicol.
Therapeutic test
Grouping and processing:
200 of natural infection suckling pigs are fallen ill in birth 2～20 ages in days, body weight 2～3kg, essenceGod is depressed, draws yellow-white loose stool, and appetite is fallen, and the 20% sick pigskin colour of skin is light. By to morbidity pig clinicalSymptom Observation, pathology cut open inspection, in conjunction with laboratory diagnosis, are diagnosed as piglet yellow scour and son that Escherichia coli causePig dysentery characterized by white mucous stool.
Sick pig is divided into 2 groups at random, and 100 every group, what wherein prepared by treatment group feeding embodiment 5 raisesMaterial, control group Florfenicol oral administration adopts conventional corn feed feeding simultaneously; Each group all connectsContinuous medication 3d, every day 1 time, and in conjunction with compound physiological saline lumbar injection, to alleviate dehydration and to supplementElectrolyte.
Curative effect determinate standard: to each observation 1 time of sick pig every day at upper and lower noon, until after death or rehabilitation 2Week, observe each group of pig spirit, search for food, drink water, breathing, ight soil, death, Gain weight and medicationAfter variation etc. Curative effect judging standard is as follows: cure: after medication, the clinical symptoms such as sick diarrhea of pigs are completeDisappear, spirit, appetite etc. are recovered normally, recidivist not in 2 weeks after drug withdrawal. Effective: after medication, sick pigThe clinical symptoms such as diarrhoea alleviate to some extent, disappearance or the course of disease shorten. Invalid: after medication, sick diarrhea of pigs etc. faceBed symptom and spirit, appetite etc. are all unchanged, even increase the weight of, and occur the phenomena of mortality.
Statistical method
Measurement data adoptsRepresent, between group, relatively adopt χ2Inspection, all data all adoptThe processing of SPSS12.0 statistical software.
Results and analysis
To causing the Escherichia coli drug sensitive test of piglet yellow-white dysentery, the results are shown in Table 1.
Table 1 is to causing the Escherichia coli drug sensitive test result mm of piglet yellow-white dysentery
Table 1 shows, drug sensitive test result show enteropathogenic E．Coli to Multiple Classes of Antibiotics as Fourth RingElement, orfloxacin, amikacin, erythromycin, ampicillin etc. produce drug resistance, to gentamicin alsoMore responsive, Florfenicol sensitiveness is the highest, and this test uses Chinese medicine composition additive in highly quickSense.
The result for the treatment of of piglet yellow-white dysentery, the results are shown in Table 2.
The result for the treatment of of table 2 piglet yellow-white dysentery
| Group | Number | Cure | Effectively | Invalid | Total effective rate |
| Treatment group | 100 | 95 | 4 | 1 | 99％ |
| Control group | 100 | 79 | 13 | 8 | 92％ |
As can be seen from Table 2, adopt Chinese medicine composition additive provided by the invention at treatment piglet yellow-whiteDysentery aspect is evident in efficacy.
All above-mentioned these intellectual properties of primary enforcement, do not set the other forms of enforcement of restriction thisPlant new product and/or new method. Those skilled in the art will utilize this important information, foregoing amendment,To realize similar implementation status. But all modifications or transformation belong to reservation based on new product of the present inventionRight.
The above, be only preferred embodiment of the present invention, is not that the present invention is made to other formRestriction, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changedOr be modified as the equivalent embodiment of equivalent variations. But every technical solution of the present invention content that do not depart from, complies withAny simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention,Still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. for preventing and treating a feed for piglet yellow-white dysentery, it is characterized in that: raw material comprises corn, dregs of beans, salt, fish meal, soya-bean oil, amino acid additive, vitamin(e) supplement, for preventing and treating the Chinese medicine composition additive of piglet yellow-white dysentery;
The weight portion of each raw material is respectively corn 280 weight portion～320 weight portions, dregs of beans 140 weight portion～160 weight portions, salt 3 weight portion～5 weight portions, fish meal 30 weight portion～40 weight portions, soya-bean oil 20 weight portion～30 weight portions, amino acid additive 1 weight portion～3 weight portion, vitamin(e) supplement 1 weight portion～3 weight portion, Chinese medicine composition additive 40 weight portion～60 weight portions;
The bulk drug of described Chinese medicine composition additive by faenum graecum, in one's early teens, dandelion, cordate houttuynia, the coptis, Gorgon fruit, asparagus fern, Chinese ephedra, play both sides of the street, radix bupleuri, the dried immature fruit of citron orange, potentilla discolor, white wine grass, bark of ash, Samson St Johswort, the root of herbaceous peony, parasitic loranthus, franzenbach rhubarb root and rhizome, galangal, Japanese cryptotaenia stem and leaf, caulis lonicerae, cortex acanthopanacis, Rabdosia amethystoides, kalimeris, reticulate millettia, Chinese yam and American Ginseng form;
In described Chinese medicine composition additive, the weight portion of each bulk drug is respectively faenum graecum 25 weight portion～35 weight portions, 15 weight portion～25 weight portions in one's early teens, dandelion 60 weight portion～70 weight portions, cordate houttuynia 30 weight portion～40 weight portions, the coptis 35 weight portion～45 weight portions, Gorgon fruit 25 weight portion～35 weight portions, asparagus fern 30 weight portion～40 weight portions, Chinese ephedra 20 weight portion～30 weight portions, 15 weight portion～25 weight portions play both sides of the street, radix bupleuri 15 weight portion～25 weight portions, the dried immature fruit of citron orange 20 weight portion～30 weight portions, potentilla discolor 15 weight portion～25 weight portions, white wine grass 25 weight portion～35 weight portions, bark of ash 20 weight portion～30 weight portions, Samson St Johswort 25 weight portion～35 weight portions, the root of herbaceous peony 30 weight portion～40 weight portions, parasitic loranthus 25 weight portion～35 weight portions, franzenbach rhubarb root and rhizome 20 weight portion～30 weight portions, galangal 20 weight portion～30 weight portions, Japanese cryptotaenia stem and leaf 20 weight portion～30 weight portions, caulis lonicerae 25 weight portion～35 weight portions, cortex acanthopanacis 30 weight portion～40 weight portions, Rabdosia amethystoides 25 weight portion～35 weight portions, kalimeris 15 weight portion～25 weight portions, reticulate millettia 35 weight portion～45 weight portions, Chinese yam 40 weight portion～50 weight portions and American Ginseng 35 weight portion～45 weight portions.
2. feed as claimed in claim 1, is characterized in that: described amino acid additive comprises serine, glutamic acid, glycine, isoleucine, leucine, alanine, proline.
3. feed as claimed in claim 1, is characterized in that: described amino acid additive comprises amino acid premix.
4. the feed as described in claims 1 to 3 any one, is characterized in that: described vitamin(e) supplement comprises riboflavin, vitamin C, vitamin E, vitamin A, Cobastab.
5. the feed as described in claims 1 to 3 any one, is characterized in that: described vitamin(e) supplement comprises vitamin premix.
6. the preparation method of feed described in claim 1 or 2, is characterized in that, comprising:
The first step, mixes the each raw material components in Chinese medicine composition additive by weight, every 100g mixture, add the water of 500g～600g, boil 3 ~ 4 hours, filter, obtain the first filtrate, filter residue adds the water of 200g～300g again, again boils 1 ~ 2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the concentrated aqueous solvent of removing, pulverize, dry, obtain Chinese medicine composition additive;
Second step, puts into fodder mixing machine together with the described Chinese medicine composition additive that other raw material components in feedstuff and the first step are obtained, and continuous uniform stirred after 1～3 hour, put into pulverizer and pulverized, and obtained feed.
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| CN104799003A (en) * | 2015-05-18 | 2015-07-29 | 山东新希望六和集团有限公司 | Compound feed for 10-30-day-old piglets and preparing method thereof |
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| CN101049375A (en) * | 2007-05-14 | 2007-10-10 | 无锡正大畜禽有限公司 | Composition of Chinese traditional medicine for treating yellow / white flux of baby pig, and colibacillosis of birds |
| CN101238858A (en) * | 2008-01-28 | 2008-08-13 | 吴忠尚 | Chinese medicinal composition for preventing and controlling yellow and white scour of piglets |
| CN101259171A (en) * | 2008-04-11 | 2008-09-10 | 福建农林大学 | Chinese medicine preparation for preventing pigling's yellow-white dysentery and improving immunity |
| CN101536735A (en) * | 2009-04-24 | 2009-09-23 | 崇州市旺达饲料有限公司 | Compound feed for nutrient combo for milk pigs |
| CN102613413A (en) * | 2012-04-10 | 2012-08-01 | 胡海波 | Feed and traditional Chinese medicine for treating white scour of piglets and preparation method as well as applications |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049375A (en) * | 2007-05-14 | 2007-10-10 | 无锡正大畜禽有限公司 | Composition of Chinese traditional medicine for treating yellow / white flux of baby pig, and colibacillosis of birds |
| CN101238858A (en) * | 2008-01-28 | 2008-08-13 | 吴忠尚 | Chinese medicinal composition for preventing and controlling yellow and white scour of piglets |
| CN101259171A (en) * | 2008-04-11 | 2008-09-10 | 福建农林大学 | Chinese medicine preparation for preventing pigling's yellow-white dysentery and improving immunity |
| CN101536735A (en) * | 2009-04-24 | 2009-09-23 | 崇州市旺达饲料有限公司 | Compound feed for nutrient combo for milk pigs |
| CN102613413A (en) * | 2012-04-10 | 2012-08-01 | 胡海波 | Feed and traditional Chinese medicine for treating white scour of piglets and preparation method as well as applications |
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