CN104082537B - For promoting ablactational baby pig growth and improving the medicated feed additive of immune function - Google Patents
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- CN104082537B CN104082537B CN201410230973.4A CN201410230973A CN104082537B CN 104082537 B CN104082537 B CN 104082537B CN 201410230973 A CN201410230973 A CN 201410230973A CN 104082537 B CN104082537 B CN 104082537B
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Abstract
The invention provides a kind of for promoting ablactational baby pig growth and improving the medicated feed additive of immune function, its crude drug includes Radix Campanumoeae, Semen Euryales, Bulbus Allii, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi, Fructus Corni, assorted Chinese medicine tea, Herba Siegesbeckiae, Radix Urenae Lobatae, achillea millefolium, Concretio Silicea Bambusae, Herba Asteris Ageratoidis, Ootheca Mantidis, Fructus Broussonetiae, Dioscorea septemloba Thunb. moss, Herba Dendrobii, Fructus Citri Sarcodactylis, Radix Panacis Quinquefolii, Fructus Litseae, Radix Curcumae, Fructus Hippophae, Radix Scutellariae, Coriolous Dersicolor (Fr.) Quel, Herba stachydis oblongifoliae, Rhizoma Saururi (Herba Saururi) and Herba balanophorae involucratae. This medicated feed additive can promote piglet metabolism, promotes growth and development, improves and produces performance, improving the immunity of piglet body, disease preventing and treating, relative to antibiotic, hormone, chemical synthetic drug, it is prevented from remaining at piglet drug disposition, has no side effect.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of for promoting ablactational baby pig growth and improving the medicated feed additive of immune function.
Background technology
Ablactational baby pig is also referred to as nursery pig, and after referring to birth, 3-5 week old weans to the piglet in 10 week old stages. Under natural conditions, weaned piglet is progressive process, it usually needs 17 weeks. Under modern yard feeding pattern, for improving sow utilization rate, weaned piglet age in days shifts to an earlier date therewith, causes piglet that a series of physiological change occurs: diarrhea rate and mortality rate raise, premunition declines, poor growth is stagnated.
Widely used early weaned technology in modern intensive Swine Production, after piglet leaves sow, suddenly change at feeding environment and nutrition, again gregarious, set up under the effect of the undesirable elements such as new order of grade, it is easy to occurring stress syndrome with poor growth and the early weaning piglet that diarrhoea is principal character. There is due to this disease higher incidence rate and mortality rate, carried out heavy losses to industrial belt of raising pigs.
At present, commonly used interpolation antibiotic in feedstuff in Animal husbandry production, hormone, chemical synthetic drugs etc. prevent and treat livestock and poultry diarrhea, these materials of life-time service, pathogenic microorganism is not only easily caused to produce drug resistance, the problems such as animal immunizing power decline and deterioration in quality, these materials are in livestock meat, milk, the food safety question that residual in egg and edibility internal organs causes, and in the animal body that causes of antibiotic bacterial drug resistance to the transfer of human disease bacterium, all cause the great attention of national governments, and make laws restriction is made in the use of these materials, therefore the exploitation of natural resources become and enjoy popular confidence.
Chinese herbal medicine is to be taken at nature and maintain its natural structure and bioactive natural drug, its abundance, with low cost, effect is extensively, both contained nutrient substance, there is again calmness of calming the nerves, stomach invigorating digestion promoting, vital energy regualting and blood circulation-promoting, the tonification of foster essence, anthelmintic health care and the effect of preventing and curing diseases. In feed industry, exploitation application Chinese herbal medicine additive replaces antibiotic and chemical synthetic drug, is extremely important.
Chinese herbal medicine has medicine and nutrition dual function, both preventable disease concurrently as feed additive, can improve again production performance.Theory analysis from modern pharmacology and threpsology, Chinese herbal medicine is containing bioactive substances such as anti-(pressing down) bacterium composition, alkaloid, polysaccharide, two classes, volatile oil, boots matter and organic acid, simultaneously possibly together with a number of aminoacid, mineral, vitamin, unknown growth regulator and pigment, it is thus able to the effect by antibiotic substance and immunologic active material, improves the premunition of body. Improve the utilization rate of nutrient substance, promote the performance of breeding performonce fo animals.
Summary of the invention
The technical problem to be solved is to provide a kind of for promoting ablactational baby pig growth and improving the medicated feed additive of immune function and the feedstuff comprising this feed additive, adopt this medicated feed additive can promote piglet metabolism, promote growth and development, improve and produce performance, improving the immunity of piglet body, disease preventing and treating, relative to antibiotic, hormone, chemical synthetic drug, it is prevented from remaining at piglet drug disposition, has no side effect.
For solving above-mentioned technical problem, the invention provides a kind of for promoting ablactational baby pig growth and improving the medicated feed additive of immune function, its crude drug includes Radix Campanumoeae, Semen Euryales, Bulbus Allii, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi, Fructus Corni, assorted Chinese medicine tea, Herba Siegesbeckiae, Radix Urenae Lobatae, achillea millefolium, Concretio Silicea Bambusae, Herba Asteris Ageratoidis, Ootheca Mantidis, Fructus Broussonetiae, Dioscorea septemloba Thunb. moss, Herba Dendrobii, Fructus Citri Sarcodactylis, Radix Panacis Quinquefolii, Fructus Litseae, Radix Curcumae, Fructus Hippophae, Radix Scutellariae, Coriolous Dersicolor (Fr.) Quel, Herba stachydis oblongifoliae, Rhizoma Saururi (Herba Saururi) and Herba balanophorae involucratae.
Wherein, the weight of each crude drug respectively Radix Campanumoeae 30g��40g in described medicated feed additive, Semen Euryales 25g��35g, Bulbus Allii 20g��30g, Fructus Crataegi 20g��30g, Radix Et Caulis Acanthopanacis Senticosi 30g��40g, Fructus Corni 35g��45g, assorted Chinese medicine tea 15g��25g, Herba Siegesbeckiae 10g��20g, Radix Urenae Lobatae 20g��30g, achillea millefolium 20g��30g, Concretio Silicea Bambusae 25g��35g, Herba Asteris Ageratoidis 15g��25g, Ootheca Mantidis 20g��30g, Fructus Broussonetiae 20g��30g, Dioscorea septemloba Thunb. moss 10g��20g, Herba Dendrobii 15g��25g, Fructus Citri Sarcodactylis 10g��20g, Radix Panacis Quinquefolii 55g��65g, Fructus Litseae 15g��25g, Radix Curcumae 20g��30g, Fructus Hippophae 20g��30g, Radix Scutellariae 35g��45g, Coriolous Dersicolor (Fr.) Quel 15g��25g, Herba stachydis oblongifoliae 20g��30g, Rhizoma Saururi (Herba Saururi) 15g��25g and Herba balanophorae involucratae 10g��20g.
Wherein, the weight of each crude drug respectively Radix Campanumoeae 33g��37g in described medicated feed additive, Semen Euryales 28g��32g, Bulbus Allii 23g��27g, Fructus Crataegi 23g��27g, Radix Et Caulis Acanthopanacis Senticosi 33g��37g, Fructus Corni 38g��42g, assorted Chinese medicine tea 18g��22g, Herba Siegesbeckiae 13g��17g, Radix Urenae Lobatae 23g��27g, achillea millefolium 23g��27g, Concretio Silicea Bambusae 28g��32g, Herba Asteris Ageratoidis 18g��22g, Ootheca Mantidis 23g��27g, Fructus Broussonetiae 23g��27g, Dioscorea septemloba Thunb. moss 13g��17g, Herba Dendrobii 18g��22g, Fructus Citri Sarcodactylis 13g��17g, Radix Panacis Quinquefolii 58g��62g, Fructus Litseae 18g��22g, Radix Curcumae 23g��27g, Fructus Hippophae 23g��27g, Radix Scutellariae 38g��42g, Coriolous Dersicolor (Fr.) Quel 18g��22g, Herba stachydis oblongifoliae 23g��27g, Rhizoma Saururi (Herba Saururi) 18g��22g and Herba balanophorae involucratae 13g��17g.
Wherein, the weight of each crude drug respectively Radix Campanumoeae 35g, Semen Euryales 30g, Bulbus Allii 25g, Fructus Crataegi 25g, Radix Et Caulis Acanthopanacis Senticosi 35g, Fructus Corni 40g, assorted Chinese medicine tea 20g, Herba Siegesbeckiae 15g, Radix Urenae Lobatae 25g, achillea millefolium 25g, Concretio Silicea Bambusae 30g, Herba Asteris Ageratoidis 20g, Ootheca Mantidis 25g, Fructus Broussonetiae 25g, Dioscorea septemloba Thunb. moss 15g, Herba Dendrobii 20g, Fructus Citri Sarcodactylis 15g, Radix Panacis Quinquefolii 60g, Fructus Litseae 20g, Radix Curcumae 25g, Fructus Hippophae 25g, Radix Scutellariae 40g, Coriolous Dersicolor (Fr.) Quel 20g, Herba stachydis oblongifoliae 25g, Rhizoma Saururi (Herba Saururi) 20g and Herba balanophorae involucratae 15g in described medicated feed additive.
The preparation method that present invention also offers said medicine feed additive, particularly as follows:
Each crude drug is respectively crushed into powder, sends into stirrer for mixing, it is thus achieved that mixture, every 100g mixture, adds the water of 500g��600g, boils 3��4 hours, filtering, it is thus achieved that the first filtrate, filtering residue adds the water of 200g��300g again, again boil 1��2 hour, filter, it is thus achieved that the second filtrate, first filtrate and the second filtrate being mixed, concentration removes aqueous solvent, pulverizes, dry, it is thus achieved that dry powder, it is medicated feed additive.
Present invention also offers a kind of for promote ablactational baby pig growth and improve immune function feedstuff, its raw material include Semen Maydis, bean cake, Sal, fish flour, Oleum Glycines, methionine, lysine, tryptophan, VitAVitE, vitamin C and above-mentioned for promote ablactational baby pig growth and improve immune function medicated feed additive.
Wherein, the weight portion of each raw material respectively Semen Maydis 280 weight portion��320 weight portion, bean cake 140 weight portion��160 weight portion, Sal 3 weight portion��5 weight portion, fish flour 30 weight portion��40 weight portion, Oleum Glycines 20 weight portion��30 weight portion, methionine 1 weight portion��3 weight portion, lysine 1 weight portion��3 weight portion, tryptophan 1 weight portion��3 weight portion, dehydroretinol weight portion��4 weight portion, vitamin E2 weight portion��4 weight portion, Catergen weight portion��4 weight portion, Chinese medicine feed additive 55 weight portion��65 weight portion in described feedstuff.
Wherein, the weight portion of each raw material respectively Semen Maydis 300 weight portion, bean cake 150 weight portion, Sal 4 weight portion, fish flour 35 weight portion, Oleum Glycines 25 weight portion, methionine 2 weight portion, lysine 2 weight portion, tryptophan 2 weight portion, 3-Hydroxyretinol weight portion, vitamin E 3 weight portion, vitamin C 3 weight portion, medicated feed additive 60 weight portion in described feedstuff.
The preparation method that present invention also offers above-mentioned feedstuff, including:
The first step, prepares described medicated feed additive;
Second step, put in fodder mixing machine together with the described medicated feed additive obtained with the first step by other raw material components in feedstuff, and continuous uniform is put in pulverizer and pulverized, it is thus achieved that feedstuff after stirring 1��3 hour.
Beneficial effects of the present invention:
The medicated feed additive that the present invention adopts can promote piglet metabolism, promotes growth and development, improves and produces performance, improving the immunity of piglet body, disease preventing and treating, relative to antibiotic, hormone, chemical synthetic drug, it is prevented from remaining at piglet drug disposition, has no side effect.
Detailed description of the invention
The invention provides a kind of for promoting ablactational baby pig growth and improving the medicated feed additive of immune function, its crude drug includes Radix Campanumoeae, Semen Euryales, Bulbus Allii, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi, Fructus Corni, assorted Chinese medicine tea, Herba Siegesbeckiae, Radix Urenae Lobatae, achillea millefolium, Concretio Silicea Bambusae, Herba Asteris Ageratoidis, Ootheca Mantidis, Fructus Broussonetiae, Dioscorea septemloba Thunb. moss, Herba Dendrobii, Fructus Citri Sarcodactylis, Radix Panacis Quinquefolii, Fructus Litseae, Radix Curcumae, Fructus Hippophae, Radix Scutellariae, Coriolous Dersicolor (Fr.) Quel, Herba stachydis oblongifoliae, Rhizoma Saururi (Herba Saururi) and Herba balanophorae involucratae.
Described medicated feed additive is it is preferred that be only made up of above-mentioned raw materials medicine.
The weight of each crude drug respectively Radix Campanumoeae 30g��40g in described medicated feed additive, Semen Euryales 25g��35g, Bulbus Allii 20g��30g, Fructus Crataegi 20g��30g, Radix Et Caulis Acanthopanacis Senticosi 30g��40g, Fructus Corni 35g��45g, assorted Chinese medicine tea 15g��25g, Herba Siegesbeckiae 10g��20g, Radix Urenae Lobatae 20g��30g, achillea millefolium 20g��30g, Concretio Silicea Bambusae 25g��35g, Herba Asteris Ageratoidis 15g��25g, Ootheca Mantidis 20g��30g, Fructus Broussonetiae 20g��30g, Dioscorea septemloba Thunb. moss 10g��20g, Herba Dendrobii 15g��25g, Fructus Citri Sarcodactylis 10g��20g, Radix Panacis Quinquefolii 55g��65g, Fructus Litseae 15g��25g, Radix Curcumae 20g��30g, Fructus Hippophae 20g��30g, Radix Scutellariae 35g��45g, Coriolous Dersicolor (Fr.) Quel 15g��25g, Herba stachydis oblongifoliae 20g��30g, Rhizoma Saururi (Herba Saururi) 15g��25g and Herba balanophorae involucratae 10g��20g.
It is preferred that, the weight of each crude drug respectively Radix Campanumoeae 33g��37g in described medicated feed additive, Semen Euryales 28g��32g, Bulbus Allii 23g��27g, Fructus Crataegi 23g��27g, Radix Et Caulis Acanthopanacis Senticosi 33g��37g, Fructus Corni 38g��42g, assorted Chinese medicine tea 18g��22g, Herba Siegesbeckiae 13g��17g, Radix Urenae Lobatae 23g��27g, achillea millefolium 23g��27g, Concretio Silicea Bambusae 28g��32g, Herba Asteris Ageratoidis 18g��22g, Ootheca Mantidis 23g��27g, Fructus Broussonetiae 23g��27g, Dioscorea septemloba Thunb. moss 13g��17g, Herba Dendrobii 18g��22g, Fructus Citri Sarcodactylis 13g��17g, Radix Panacis Quinquefolii 58g��62g, Fructus Litseae 18g��22g, Radix Curcumae 23g��27g, Fructus Hippophae 23g��27g, Radix Scutellariae 38g��42g, Coriolous Dersicolor (Fr.) Quel 18g��22g, Herba stachydis oblongifoliae 23g��27g, Rhizoma Saururi (Herba Saururi) 18g��22g and Herba balanophorae involucratae 13g��17g.
There is most choosing, the weight of each crude drug respectively Radix Campanumoeae 35g, Semen Euryales 30g, Bulbus Allii 25g, Fructus Crataegi 25g, Radix Et Caulis Acanthopanacis Senticosi 35g, Fructus Corni 40g, assorted Chinese medicine tea 20g, Herba Siegesbeckiae 15g, Radix Urenae Lobatae 25g, achillea millefolium 25g, Concretio Silicea Bambusae 30g, Herba Asteris Ageratoidis 20g, Ootheca Mantidis 25g, Fructus Broussonetiae 25g, Dioscorea septemloba Thunb. moss 15g, Herba Dendrobii 20g, Fructus Citri Sarcodactylis 15g, Radix Panacis Quinquefolii 60g, Fructus Litseae 20g, Radix Curcumae 25g, Fructus Hippophae 25g, Radix Scutellariae 40g, Coriolous Dersicolor (Fr.) Quel 20g, Herba stachydis oblongifoliae 25g, Rhizoma Saururi (Herba Saururi) 20g and Herba balanophorae involucratae 15g in described medicated feed additive.
Each crude drug pharmacology is as follows:
Radix Campanumoeae: latin name radixcampanumoeajavanicae, for the root of campanulaceae leopard platymiscium Campanumoea javanica Yu leopard, sweet in the mouth, property is put down, and returns lung, spleen channel, has invigorating the spleen and benefiting QI, tonifying the lung and stopping cough, effect of stimulating milk secretion, cures mainly labor void internal injury, and the deficiency of vital energy is weak, cardiopalmus, hyperhidrosis, diarrhea due to hypofunction of the spleen, leucorrhea, the cards such as milk is rare, insufficiency of the spleen cough. Semen Euryales:
Bulbus Allii: warm in nature, acrid in the mouth is put down; Enter spleen, stomach, lung meridian, have warming middle-JIAO help digestion, the stagnant gas of row, warming the spleen and stomach, removing food stagnancy, removing toxic substances, parasite killing effect, cure mainly eating accumulation, coldness and pain in the epigastrium, edema distension, have loose bowels, dysentery, malaria, pertussis, swollen ulcer drug, white bald tinea skin ulcer, snake bite and insect sting and the card such as ancylostome, pinworm.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature, return spleen, stomach, Liver Channel, for promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, be mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, have loose bowels, dysentery, Fructus Crataegi is the regular supplies for the treatment of dyspepsia, and Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; Dysentery bacterium, escherichia coli, bacillus pyocyaneus, staphylococcus aureus etc. had obvious inhibitory action.
Radix Et Caulis Acanthopanacis Senticosi: for the root of studies on plants of Acanthopanax Miq. in Araliaceae Radix Et Caulis Acanthopanacis Senticosi, rhizome or stem and leaf, latin name AcanthopanacisSenticosiRadixetRhizomaseuCaulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, demonstrate,proves for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity is soft, be slow in action, body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched etc.
Fructus Corni: latin name cornifructus, sour in the mouth, puckery, slightly warm in nature, enter liver, kidney channel, the effect having liver and kidney tonifying, arresting seminal emission, arresting sweating admittedly to take off, it is mainly used in the hepatic and renal YIN deficiency, the soreness of the waist and knees of excessive rising of liver-YANG, dizziness and tinnitus, sexual impotence, essence closes the cards such as not solid seminal emission, spermatorrhea, metrostaxis.
Assorted Chinese medicine tea: bitter in the mouth, pungent, cold nature, there is blood stasis dispelling regulating menstruation, effect of removing obstruction in the collateral to relieve pain, cure mainly the cards such as menoxenia, puerperal abdonimal pain, treating swelling and pain by traumatic injury, hemiplegia.
Herba Siegesbeckiae: latin name SiegesbeckiaeHerba, taste is cold, pungent, bitter, returns Liver Channel, kidney channel, has wind-damp dispelling, profit joint, effect of removing toxic substances, cures mainly the card such as rheumatic arthralgia, muscles and bones unable, soreness of the waist and knees, quadriplegia, hemiplegia, rubella eczema.
Radix Urenae Lobatae: sweet in the mouth, light, property is put down, and enters the heart, lung meridian, has expelling wind and removing dampness, and effect of heat-clearing and toxic substances removing cures mainly cold, fever, rheumatic arthralgia, dysentery, edema, leucorrhea, spit blood, carbuncle, traumatic hemorrhage, venom, acute infantile convulsion, tetanus, asthma, stomachache puerperal exposure to wind etc. is demonstrate,proved.
Achillea millefolium: acrid in the mouth; Bitter; Property flat temperature, there is wind-expelling pain-stopping; Effect of promoting blood circulation and detoxication, cures mainly cold, fever; Wind syndrome of head pain; Toothache; Rheumatic arthralgia; Blood stasis amenorrhea; Abdominal part mass in the abdomen; Traumatic injury; Venom; Carbuncle sore tumefacting virus etc. are demonstrate,proved.
Concretio Silicea Bambusae: sweet in the mouth, cold in nature, there is clear heat and eliminate phlegm, effect of cool heart arresting convulsion, cure mainly calentura coma delirium, middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion. Phlegm-heat coughs etc. are demonstrate,proved.
Herba Asteris Ageratoidis: bitter in the mouth, pungent, cool in nature, there is heat-clearing and toxic substances removing, the effect of the removing heat from blood that eliminates the phlegm, cure mainly cold, fever, tonsillitis, bronchitis, hepatitis, enteritis, pyretic stranguria, carbuncle furunculosis, the card such as snake bite and insect sting.
Ootheca Mantidis: latin name OothecaMantidis, becomes sweet, flat, returns liver, kidney, bladder warp, there is the kidney invigorating, astringent or styptic treatment for spontaneous sweating, only effect of something lost, curing mainly the cards such as the bed-wetting of insufficiency of kidney-YANG, frequent urination at night, seminal emission premature ejaculation, sexual impotence, not only tonification but also astringent therapy, for the good medicine of reinforcing the kidney and supporting YANG, controlling nocturnal emission with astringent drugs reducing urination. The solid caused emission and spermatorrhea of all kidney yang deficiencies, vital essence mistake, the enuresis, frequent micturition, sexual impotence are sterile, all can be selected for, especially should the enuresis, frequent micturition.
Fructus Broussonetiae: sweet in the mouth, cold in nature, return liver, kidney channel, there is the kidney invigorating liver heat removing, effect of improving eyesight diuresis, cure mainly deficiency of the liver and kindey, soreness of the waist and knees, asthenia hectic fever due to YIN-deficiency, have a dizzy spell, the card such as edema distension.
Dioscorea septemloba Thunb. moss: latin name DioscoreaeSpongiosaeRhizoma, property is put down, and bitter in the mouth is returned kidney, stomach warp, had dampness removing and go turbid, the effect of the blood stasis dispelling that dispels the wind, and demonstrate,proves for gonorrhea nebulousurine, leukorrhagia, damp and hot sore, waist knee joint arthralgia pain etc.
Herba Dendrobii: latin name DendrobiiCaulis, cold nature, sweet in the mouth, returns stomach, kidney channel, has reinforcing stomach reg fluid, effect of nourishing YIN and clearing away heat, cures mainly cloudy impairment of body fluid and loses, xerostomia excessive thirst, the cards such as lack of appetite is retched, deficiency-heat after being ill, poor vision.
Fructus Citri Sarcodactylis: acrid in the mouth, hardship, warm in nature, return liver, stomach, lung meridian, there is soothing the liver circulation of qi promoting, and in effect of reducing phlegm, for cards such as the distending pain in the chest and hypochondrium of stagnation of QI due to depression of the liver, incoordination between the liver and stomach, stagnation of QI in spleen and stomach, vomiting and nausea lack of appetite.
Radix Panacis Quinquefolii: sweet in the mouth, micro-hardship, cool in nature, GUIXIN, lung, kidney channel, there is boosting qi and nourishing yin, effect of clearing away heat and promoting production of body fluid, cure mainly deficiency of vital energy yin deficiency, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat.
Fructus Litseae: warm in nature, acrid in the mouth, to return spleen, stomach, kidney, bladder warp, there is warming spleen and stomach for dispelling cold, effect of promoting the circulation of QI to relieve pain, for cold syndrome of the stomach vomiting, coldness and pain in the epigastrium, the cards such as colic of cold type is suffered from abdominal pain, stagnancy of cold-damp.
Radix Curcumae: acrid in the mouth, hardship, cold in nature, return liver, the heart, lung meridian, there is regulating qi to disperse stagnation, heart fire-clearing upset-relieving, effect of promoting the function of the gallbladder to alleviate jaundice, cure mainly amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, the cards such as epilepsy is gone mad, jaundice dark coloured urine.
Fructus Hippophae: latin name HippophaeFructus, sour in the mouth; Puckery; Warm in nature, there is relieving cough and resolving phlegm; Invigorating the stomach and promoting digestion; Effect of promoting blood circulation to remove blood stasis. Cure mainly cough with copious phlegm; Pulmonary abscess; Dyspepsia; Abdominal pain due to retention of food; Stomachache; Intestinal is scorching; Amenorrhea; Traumatic injury congestive edema etc. are demonstrate,proved.
Radix Scutellariae: latin name ScutellariaeRadix, bitter in the mouth, cold in nature, enter the heart, lung, stomach, gallbladder, large intestine channel, have a heat clearing and damp drying, eliminating fire and detoxication, antiabortive, the effect of hemostasis, it is mainly used in damp and hot caused diarrhoea, dysentery, jaundice, pyretic stranguria; Cough due to lung-heat, thirsty pharyngalgia, it may also be used for excessive fetal movement due to heat in pregnancy, pyretic toxicity pathogenic fire invades the card that the carbuncle sore poison of excessive skin swells.
Coriolous Dersicolor (Fr.) Quel: latin name Coriolus, sweet in the mouth, light, cold nature, return liver;Spleen; Lung meridian, has invigorating spleen to remove dampness; Relieving cough and asthma; Heat-clearing and toxic substances removing; Antineoplastic effect, cures mainly chronic active hepatitis; Hepatitis interstitialis chronica; Chronic bronchitis; Infantile spasm bronchitis; Laryngopharynx swelling and pain; Kinds of tumors; Rheumatoid arthritis; Leukemia etc. are demonstrate,proved.
Herba stachydis oblongifoliae: for herb or the root of the oval leaf Herba Stachydis Japonicae of Labiatae betony, acrid in the mouth, micro-sweet, warm in nature, there is QI invigorating, effect of hemostasis, cure mainly weak after being ill, the cards such as the deficiency of vital energy is weak, chronic dysentery, traumatic hemorrhage.
Rhizoma Saururi (Herba Saururi): latin name SaururiHerba, sweet in the mouth, pungent, cold in nature, return lung, bladder warp, there is clearing away heat and promoting diuresis; Effect of removing toxic substances and promoting subsidence of swelling, cures mainly pyretic stranguria; Stranguria with blood; Edema; Foot gas; Jaundice; Dysentery; Leukorrhagia; Carbuncle sore tumefacting virus; Eczema; Venom etc. are demonstrate,proved.
Herba balanophorae involucratae: bitter in the mouth, puckery, cold in nature, return lung, stomach, Liver Channel, there is nourishing the lung to arrest cough, circulation of qi promoting stomach invigorating, clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, effect of the kidney invigorating arresting seminal emission, address cough due to lung-heat, wrist abdomen pain, jaundice, traumatic injury, spitting of blood, menoxenia, metrorrhagia, traumatic hemorrhage, dizzy, seminal emission etc. is demonstrate,proved.
The preparation method that present invention also offers said medicine feed additive, particularly as follows:
Each crude drug is respectively crushed into powder, sends into stirrer for mixing, it is thus achieved that mixture, every 100g mixture, adds the water of 500g��600g, boils 3��4 hours, filtering, it is thus achieved that the first filtrate, filtering residue adds the water of 200g��300g again, again boil 1��2 hour, filter, it is thus achieved that the second filtrate, first filtrate and the second filtrate being mixed, concentration removes aqueous solvent, pulverizes, dry, it is thus achieved that dry powder, it is medicated feed additive.
Present invention also offers a kind of for promote ablactational baby pig growth and improve immune function feedstuff, its raw material include Semen Maydis, bean cake, Sal, fish flour, Oleum Glycines, methionine, lysine, tryptophan, VitAVitE, vitamin C and above-mentioned for promote ablactational baby pig growth and improve immune function medicated feed additive.
Further, described feedstuff is only made up of above-mentioned raw materials.
Further, the weight portion of each raw material respectively Semen Maydis 280 weight portion��320 weight portion, bean cake 140 weight portion��160 weight portion, Sal 3 weight portion��5 weight portion, fish flour 30 weight portion��40 weight portion, Oleum Glycines 20 weight portion��30 weight portion, methionine 1 weight portion��3 weight portion, lysine 1 weight portion��3 weight portion, tryptophan 1 weight portion��3 weight portion, dehydroretinol weight portion��4 weight portion, vitamin E2 weight portion��4 weight portion, Catergen weight portion��4 weight portion, Chinese medicine feed additive 55 weight portion��65 weight portion in described feedstuff.
Further, the weight portion of each raw material respectively Semen Maydis 300 weight portion, bean cake 150 weight portion, Sal 4 weight portion, fish flour 35 weight portion, Oleum Glycines 25 weight portion, methionine 2 weight portion, lysine 2 weight portion, tryptophan 2 weight portion, 3-Hydroxyretinol weight portion, vitamin E 3 weight portion, vitamin C 3 weight portion, medicated feed additive 60 weight portion in described feedstuff.
The preparation method that present invention also offers above-mentioned feedstuff, including:
The first step, prepares described medicated feed additive;
Second step, put in fodder mixing machine together with the described medicated feed additive obtained with the first step by other raw material components in feedstuff, and continuous uniform is put in pulverizer and pulverized, it is thus achieved that feedstuff after stirring 1��3 hour.
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 medicated feed additive 1
By Radix Campanumoeae 35g, Semen Euryales 30g, Bulbus Allii 25g, Fructus Crataegi 25g, Radix Et Caulis Acanthopanacis Senticosi 35g, Fructus Corni 40g, assorted Chinese medicine tea 20g, Herba Siegesbeckiae 15g, Radix Urenae Lobatae 25g, achillea millefolium 25g, Concretio Silicea Bambusae 30g, Herba Asteris Ageratoidis 20g, Ootheca Mantidis 25g, Fructus Broussonetiae 25g, Dioscorea septemloba Thunb. moss 15g, Herba Dendrobii 20g, Fructus Citri Sarcodactylis 15g, Radix Panacis Quinquefolii 60g, Fructus Litseae 20g, Radix Curcumae 25g, Fructus Hippophae 25g, Radix Scutellariae 40g, Coriolous Dersicolor (Fr.) Quel 20g, Herba stachydis oblongifoliae 25g, Rhizoma Saururi (Herba Saururi) 20g and Herba balanophorae involucratae 15g is respectively crushed into powder, send into stirrer for mixing, obtain mixture, every 100g mixture, add the water of 600g, boil 4 hours, filter, obtain the first filtrate, filtering residue adds the water of 300g again, again boil 2 hours, filter, obtain the second filtrate, first filtrate and the second filtrate are mixed, concentration removes aqueous solvent, pulverize, dry, obtain dry powder, it is medicated feed additive 1.
Embodiment 2 medicated feed additive 2
By Radix Campanumoeae 33g, Semen Euryales 28g, Bulbus Allii 23g, Fructus Crataegi 23g, Radix Et Caulis Acanthopanacis Senticosi 33g, Fructus Corni 38g, assorted Chinese medicine tea 18g, Herba Siegesbeckiae 13g, Radix Urenae Lobatae 23g, achillea millefolium 23g, Concretio Silicea Bambusae 28g, Herba Asteris Ageratoidis 18g, Ootheca Mantidis 23g, Fructus Broussonetiae 23g, Dioscorea septemloba Thunb. moss 13g, Herba Dendrobii 18g, Fructus Citri Sarcodactylis 13g, Radix Panacis Quinquefolii 58g, Fructus Litseae 18g, Radix Curcumae 23g, Fructus Hippophae 23g, Radix Scutellariae 38g, Coriolous Dersicolor (Fr.) Quel 18g, Herba stachydis oblongifoliae 23g, Rhizoma Saururi (Herba Saururi) 18g and Herba balanophorae involucratae 13g is respectively crushed into powder, send into stirrer for mixing, obtain mixture, every 100g mixture, add the water of 600g, boil 4 hours, filter, obtain the first filtrate, filtering residue adds the water of 300g again, again boil 2 hours, filter, obtain the second filtrate, first filtrate and the second filtrate are mixed, concentration removes aqueous solvent, pulverize, dry, obtain dry powder, it is medicated feed additive 2.
Embodiment 3 medicated feed additive 3
By Radix Campanumoeae 37g, Semen Euryales 32g, Bulbus Allii 27g, Fructus Crataegi 27g, Radix Et Caulis Acanthopanacis Senticosi 37g, Fructus Corni 42g, assorted Chinese medicine tea 22g, Herba Siegesbeckiae 17g, Radix Urenae Lobatae 27g, achillea millefolium 27g, Concretio Silicea Bambusae 32g, Herba Asteris Ageratoidis 22g, Ootheca Mantidis 27g, Fructus Broussonetiae 27g, Dioscorea septemloba Thunb. moss 13g, Herba Dendrobii 22g, Fructus Citri Sarcodactylis 17g, Radix Panacis Quinquefolii 62g, Fructus Litseae 22g, Radix Curcumae 27g, Fructus Hippophae 27g, Radix Scutellariae 42g, Coriolous Dersicolor (Fr.) Quel 22g, Herba stachydis oblongifoliae 27g, Rhizoma Saururi (Herba Saururi) 22g and Herba balanophorae involucratae 17g is respectively crushed into powder, send into stirrer for mixing, obtain mixture, every 100g mixture, add the water of 600g, boil 4 hours, filter, obtain the first filtrate, filtering residue adds the water of 300g again, again boil 2 hours, filter, obtain the second filtrate, first filtrate and the second filtrate are mixed, concentration removes aqueous solvent, pulverize, dry, obtain dry powder, it is medicated feed additive 3.
Embodiment 4 toxicology test
Acute toxicity testing
Select Kunming mouse 20, female half and half, body weight (20+2) g, being thered is provided by Qingdao City's Experimental Animal Center, the medicated feed additive 1 embodiment 1 prepared is dissolved in distilled water, prepares into the solution of 1g/ml, gavage mice, through preliminary experiment, fail to detect the LD of oral administration50, therefore survey its maximum tolerated dose, with the administration volume of 2.0ml/10g body weight, gavage 2 times/d, interval 6h, to observation post administration 7d, record animal dead and toxicity symptom, when experiment terminates, process all animals, dissecting, each main organs lesion tissue situation of perusal, after gavaging 140g crude drug/kg for 2 times, animal activity, feed water inlet does not show any abnormalities, and observes 7d animal dead, and gross necropsy has no the obvious abnormal of main organs tissue.
Long term toxicity test
Select 40 male SD rats, weight (180 �� 20) g, thered is provided by Qingdao City's Experimental Animal Center, it is randomly divided into 2 groups, blank group and Chinese drug-treated group, often group 20, blank group gives distilled water, the medicated feed additive 1 that embodiment 1 is prepared by Chinese drug-treated group is dissolved in distilled water, prepare into the solution of 1g/ml, gavage rat, the amount of gavaging is 50g crude drug/kg, on every Mondays to gastric infusion 1 time in morning Saturday, continuous 180d, administration volume is 2mL/100g body weight, during being administered front and administration, every day observes rat general state, sign, food ration, drinking-water and feces situation. during administration 90d after last is administered 24h, each group extracts 6, male and female half and half, during 180d after last administration 24h, each group extracts 6, male and female half and half, after drug withdrawal, 30d respectively organizes extraction 6, male and female half and half, anaesthetize with urethane, blood is taken from abdominal aortic, each group is all killed and takes animal, checks hematology and blood parameters, after taking blood, amass wealth by heavy taxation at once core, liver,kidney,spleen, lung, adrenal gland, thyroid, thymus, testis, ovary, uterus, brain, the internal organs such as prostate are weighed, according to weight calculator official's weight coefficient and make pathological examination.
On inspection, during successive administration, the activity of animal, body weight, food ration, stool and hair luster degree no abnormality seen, animal has no dead, naked eyes have no obvious pathological changes, each group rat peripheral hemogram checking is all in normal range, and the raw tea index of blood is all in normal range, and Chinese drug-treated group Rats Organs and Tissues coefficient is not significantly different from compared with blank group.
Showing through toxicology test, Chinese medicine composition feed additive provided by the invention is nontoxic.
The preparation of embodiment 5 feedstuff
Medicated feed additive 6kg prepared by Semen Maydis 30kg, bean cake 15kg, Sal 0.4kg, fish flour 3.5kg, Oleum Glycines 2.5kg, methionine 0.2kg, lysine 0.2kg, tryptophan 0.2kg, vitamin A 0.3kg, vitamin E 0.3kg, vitamin C 0.3kg, embodiment 1 is put in fodder mixing machine together, after continuous uniform stirs 2 hours, put in pulverizer and pulverize, it is thus achieved that feedstuff 1.
Embodiment 6
Test feed
The feedstuff 1 of effect group feeding embodiment 5 preparation; The feedstuff of matched group feeding is similar to feedstuff 1, is distinctive in that the medicated feed additive 1 not adding embodiment 1 preparation, but adds chlortetracycline 200g and olaquindox 150g on the basis of feedstuff 1.
Test pig: selecting parity close, average weight is about 10kg, the DLY two towering hybridization ablactational baby pig 210 that kind is identical is as test pig. Being randomly divided into two groups, matched group feeds the Basic drawing of above-mentioned interpolation chlortetracycline and olaquindox, the feedstuff 1 of effect group feeding embodiment 5 preparation. Preliminary trial period 7, is big, and experimental period 53, code insurance educates I-stage (23 days) and child care II stage (30 days).
Testing index
Produce performance: record the situations such as test pig appetite, spirit, feces, morbidity every day, weigh and record each group of every daily material consumption. In on-test, when child care I-stage, child care II stage terminate, weigh on an empty stomach by head, add up daily gain, feed-weight ratio.
Immune indexes: the collection of blood sample and process: when each process group each stage terminates, adopt 6 at random, took a blood sample the concrete time for the same day 7: 00��10: 00 of taking a blood sample, every time from vena cava anterior blood sampling 5ml, places to precipitation serum for every, 3000rpm, centrifugal 15min, Aspirate supernatant, it is distributed into fractional pack,-20 DEG C of preservations, Serum Indexes to be made measures.
Measure immune indexes and method: immunoglobulin (IgG, IgM, IgA) and complement (C3��C4) adopting end-point method, determining instrument is XD811 semi-automatic biochemical analyzer (upper Hisoon reaches medical apparatus corporation, Ltd and produces), and reagent is provided by Zhejiang Province Yilikang Bioisystech Co., Ltd.
Serum interleukin-8 adopts ELISA method, and pig IL-2 test kit is by Altru Biomedicines, Inc. of the U.S. and Fulda Biomedicines, Inc. of Canada Joint Production, and Beijing bonding Biomedicines, Inc. provides.
Data process
Data process
Measurement data adoptsRepresent, between group, compare employing x2Inspection, all data all adopt SPSS12.0 statistical software to process.
Result and discussion
The medicated feed additive impact on piglet growth performance, result is in Table 1.
The impact on piglet growth performance of table 1 medicated feed additive
As it can be seen from table 1 adopt the pig of the effect group of Chinese medicine feed additive to show good production performance, can replacing antibiotic, chemical synthetic drug to a certain extent, its price of deed rate is higher.
The medicated feed additive impact on piglet immunological globulin, result is in Table 2.
The impact on piglet immunological globulin of table 2 medicated feed additive
| Project | Group | Child care I-stage | The child care II stage |
| IgG(g/L) | Effect group | 4.292��0.315 | 4.976��0.261 |
| Matched group | 3.133��0.296 | 3.952��0.179 | |
| IgM(g/L) | Effect group | 0.586��0.049 | 0.661��0.053 |
| Matched group | 0.492��0.038 | 0.530��0.041 | |
| IgA(g/L) | Effect group | 0.736��0.029 | 0.781��0.035 |
| Matched group | 0.701��0.025 | 0.722��0.034 |
Immunoglobulin is the class globulin that can interact with antigenic specificity of internal generation after animal is subject to antigenic stimulus. Wherein, IgG has antibacterial a, antivirus action, and can neutralize a toxin and make it lose toxicity, and conditioning, coagulation and Precipitation Antigen are mostly important in humoral immunization; IgM combines with complement after body is by pathogen infection, dissolves pathogen; IgA is except playing antibiosis and antiviral functions, the local mucosal immunity such as body respiratory tract, digestive tract are also played important " barrier " effect, by table 2, it will be seen that IgG, IgM and the IgA raising amount of the piglet serum of effect group will apparently higher than matched group.
Medicated premix is to piglet SC C3��C4Impact, result is in Table 3.
Table 3 medicated premix is to piglet SC C3��C4Impact
| Project | Group | Child care I-stage | The child care II stage |
| C3(g/L) | Effect group | 0.437��0.029 | 0.551��0.039 |
| Matched group | 0.368��0.021 | 0.423��0.031 |
| C34(g/L) | Effect group | 0.069��0.012 | 0.093��0.013 |
| Matched group | 0.041��0.016 | 0.058��0.009 |
Complement is the key component of body specific immunity, participates in immunne response and the homeostatic function of body protective, assists antibody and phagocyte pathogenic microbe killing; improve the non-specific anti-infectious function of body; by table 3, it will be seen that the C of the piglet serum of effect group3��C4Content raising amount will apparently higher than matched group.
The medicated premix impact on interleukin II, result is in Table 4
Interleukin II is affected unit by table 4 medicated premix: pg/ml
| Group | Child care I-stage | The child care II stage |
| Effect group | 35.367��0.813 | 38.267��0.730 |
| Matched group | 32.173��0.639 | 33.517��0.706 |
Interleukin II is to be produced by the T lymphocyte activated and promote the factor of T lymphocyte growth, and it is the key link ensureing body normal immunological function, it is possible to by promoting the clonal expansion of a certain specific T cell colony, pass through THThe raising of cell number and function strengthens the function of entirety. Mammal research shows, interleukin II promotes that thymus is bred in a large number and secretes, promote B cell proliferation and express the performance with function, activity of interleukin-2 detection is utilized to reflect lymphocytic function, the particularly function of T cell, increasingly for the research of immunologic function, by table 4, it will be seen that the IL-2 Content raising amount of the piglet serum of effect group will apparently higher than matched group.
All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement and/or the new method that limit other forms. Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status. But, all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, and any those skilled in the art are changed or be modified as the Equivalent embodiments of equivalent variations possibly also with the technology contents of the disclosure above. But every without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and remodeling that above example is made by the technical spirit of the present invention, still fall within the protection domain of technical solution of the present invention.
Claims (4)
1. one kind is used for promoting ablactational baby pig growth and improving the medicated feed additive of immune function, it is characterised in that: crude drug is made up of Radix Campanumoeae, Semen Euryales, Bulbus Allii, Fructus Crataegi, Radix Et Caulis Acanthopanacis Senticosi, Fructus Corni, assorted Chinese medicine tea, Herba Siegesbeckiae, Radix Urenae Lobatae, achillea millefolium, Concretio Silicea Bambusae, Herba Asteris Ageratoidis, Ootheca Mantidis, Fructus Broussonetiae, Dioscorea septemloba Thunb., Herba Dendrobii, Fructus Citri Sarcodactylis, Radix Panacis Quinquefolii, Fructus Litseae, Radix Curcumae, Fructus Hippophae, Radix Scutellariae, Coriolous Dersicolor (Fr.) Quel, Herba stachydis oblongifoliae, Rhizoma Saururi (Herba Saururi) and Herba balanophorae involucratae;
The weight of each crude drug respectively Radix Campanumoeae 30g��40g in described medicated feed additive, Semen Euryales 25g��35g, Bulbus Allii 20g��30g, Fructus Crataegi 20g��30g, Radix Et Caulis Acanthopanacis Senticosi 30g��40g, Fructus Corni 35g��45g, assorted Chinese medicine tea 15g��25g, Herba Siegesbeckiae 10g��20g, Radix Urenae Lobatae 20g��30g, achillea millefolium 20g��30g, Concretio Silicea Bambusae 25g��35g, Herba Asteris Ageratoidis 15g��25g, Ootheca Mantidis 20g��30g, Fructus Broussonetiae 20g��30g, Dioscorea septemloba Thunb. 10g��20g, Herba Dendrobii 15g��25g, Fructus Citri Sarcodactylis 10g��20g, Radix Panacis Quinquefolii 55g��65g, Fructus Litseae 15g��25g, Radix Curcumae 20g��30g, Fructus Hippophae 20g��30g, Radix Scutellariae 35g��45g, Coriolous Dersicolor (Fr.) Quel 15g��25g, Herba stachydis oblongifoliae 20g��30g, Rhizoma Saururi (Herba Saururi) 15g��25g and Herba balanophorae involucratae 10g��20g.
2. medicated feed additive as claimed in claim 1, it is characterized in that: the weight of each crude drug respectively Radix Campanumoeae 33g��37g in described medicated feed additive, Semen Euryales 28g��32g, Bulbus Allii 23g��27g, Fructus Crataegi 23g��27g, Radix Et Caulis Acanthopanacis Senticosi 33g��37g, Fructus Corni 38g��42g, assorted Chinese medicine tea 18g��22g, Herba Siegesbeckiae 13g��17g, Radix Urenae Lobatae 23g��27g, achillea millefolium 23g��27g, Concretio Silicea Bambusae 28g��32g, Herba Asteris Ageratoidis 18g��22g, Ootheca Mantidis 23g��27g, Fructus Broussonetiae 23g��27g, Dioscorea septemloba Thunb. 13g��17g, Herba Dendrobii 18g��22g, Fructus Citri Sarcodactylis 13g��17g, Radix Panacis Quinquefolii 58g��62g, Fructus Litseae 18g��22g, Radix Curcumae 23g��27g, Fructus Hippophae 23g��27g, Radix Scutellariae 38g��42g, Coriolous Dersicolor (Fr.) Quel 18g��22g, Herba stachydis oblongifoliae 23g��27g, Rhizoma Saururi (Herba Saururi) 18g��22g and Herba balanophorae involucratae 13g��17g.
3. medicated feed additive as claimed in claim 1 or 2, it is characterized in that: the weight of each crude drug respectively Radix Campanumoeae 35g in described medicated feed additive, Semen Euryales 30g, Bulbus Allii 25g, Fructus Crataegi 25g, Radix Et Caulis Acanthopanacis Senticosi 35g, Fructus Corni 40g, assorted Chinese medicine tea 20g, Herba Siegesbeckiae 15g, Radix Urenae Lobatae 25g, achillea millefolium 25g, Concretio Silicea Bambusae 30g, Herba Asteris Ageratoidis 20g, Ootheca Mantidis 25g, Fructus Broussonetiae 25g, Dioscorea septemloba Thunb. 15g, Herba Dendrobii 20g, Fructus Citri Sarcodactylis 15g, Radix Panacis Quinquefolii 60g, Fructus Litseae 20g, Radix Curcumae 25g, Fructus Hippophae 25g, Radix Scutellariae 40g, Coriolous Dersicolor (Fr.) Quel 20g, Herba stachydis oblongifoliae 25g, Rhizoma Saururi (Herba Saururi) 20g and Herba balanophorae involucratae 15g.
4. the preparation method of medicated feed additive described in claim 1 or 2, it is characterised in that:
Each crude drug is respectively crushed into powder, sends into stirrer for mixing, it is thus achieved that mixture, every 100g mixture, adds the water of 500g��600g, boils 3��4 hours, filtering, it is thus achieved that the first filtrate, filtering residue adds the water of 200g��300g again, again boil 1��2 hour, filter, it is thus achieved that the second filtrate, first filtrate and the second filtrate being mixed, concentration removes aqueous solvent, pulverizes, dry, it is thus achieved that dry powder, it is medicated feed additive.
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