CN104474530A - Compound thousand-mesh superfine powder traditional Chinese veterinary preparation for promoting growth of animals and preparation method thereof - Google Patents
Compound thousand-mesh superfine powder traditional Chinese veterinary preparation for promoting growth of animals and preparation method thereof Download PDFInfo
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Abstract
A compound thousand-mesh superfine powder traditional Chinese veterinary preparation for promoting growth of animals and a preparation method thereof are disclosed. The veterinary preparation is prepared by proportionally mixing the following multiple thousand-mesh superfine powder traditional Chinese medicines and antimicrobial peptide, by weight, 6-12 parts of Radix Codonopsis, 6-12 parts of Radix Astragali, 4-8 parts of Poria cocos, 4-8 parts of Amomum globosum, 3-6 parts of bighead atractylodes rhizome, 2-4 parts of medicated leaven, 2-4 parts of malt, 2-4 parts of licorice and 15-30 parts of antibacterial peptide. The invention has characteristics as follows: the medicine provided by the invention is composed of thousand-mesh superfine powder traditional Chinese medicines and a biological agent antimicrobial peptide; the formula is reasonable, and quality is stable; and principle of compatibility is ''replenishing qi to invigorate the spleen, removing food retention and helping digestion and raising body health level''. Through compatibility of traditional Chinese medicines and antibacterial peptide for synergy, body yin-yang balance can be adjusted comprehensively, growth of animals can be promoted, price of feed can be raised, diseases can be prevented and controlled, and quality of animal products can be improved. Meanwhile, the above preparation has remarkable effects of treating inappetence, leanness, parched body hair, growth retardation and the like of animals, and has better drug effects than a single traditional Chinese medicinal preparation or antibacterial peptide. The preparation provided by the invention has advantages of wide sources of traditional Chinese medicinal raw materials and antibacterial peptide, good drug effect, no residue and no toxic or side effect, and meets current green cultivation requirements.
Description
Technical field
The present invention relates to a kind of for compound recipe thousand order superfine powder Chinese veterinary drug preparation promoting growth of animal and preparation method thereof.
Background technology
World population is in continuous growth, and people are to animal foodstuff demand in steady-state growth, and simultaneously more and more high to its prescription, therefore breeding performonce fo animals raising and animal product quality improving become the target of aquaculture unremitting pursue.Along with the propelling of intensive farm mode, animal cultivation density is large, and animal feeding density is large, easily causes animal epidemic to occur, and affects the fertility performance of animal, all cause huge loss to aquaculture every year, have impact on the sound development of aquaculture.
There are many chemical classes medicines can improve the growth performance of animal at present, as olaquindox, dihydro butanoic acid, dihydropyridine etc., it has good facilitation to the fertility performance of animal, but this quasi drugs uses many minor face factors, as drug residue affects Animal Food Security and quality, medicine production process and use procedure to the destruction of environment, bacterial drug resistance generation etc.Along with people are to the attention of food safety, current many chemical classes medicines forbid maybe can only having ready conditions use, and as olaquindox forbids the fattening stage for pig, chloromycetin, nitrofurans prohibit the use.
Chinese medicine is that China's medical soul is for thousands of years precious, many proved recipe pure Chinese medicinal preparations can significantly improve growth of animal performance or animal epidemic be played to the effect for the treatment of both the principal and secondary aspects of a disease, thousand order ultramicro powder Chinese medicines compare meal preparation can improve curative effect 3-5 doubly, the 1/5-1/3 of use amount only coarse powder.Antibacterial peptide is recently for clinical biological preparation, and it is the antibiotic substance of self secretion in animal body, and obtain by fermentation at present, it has anti-inflammation, improves the effects such as immunity of organisms.Utilize thousand order ultrafine powder traditional Chinese medicines and antibacterial peptide to make compound recipe growth promotion preparation according to a certain percentage, it can not only promote breeding performonce fo animals, and can improve the premunition of animal, improves animal product quality, and it will have wide market prospect.
Summary of the invention
The object of the invention is to provide a kind of for compound recipe thousand order superfine powder Chinese veterinary drug preparation promoting growth of animal and preparation method thereof, invention formulation can across-the-board regulation body negative and positive, promote growth of animal, enhancing immunity, disease preventing and treating, the raising price of deed and improve animal product quality, the tool such as the burnt and growth retardation of the thin hair of, body depressed to animal appetite has significant therapeutic effect simultaneously.
The present invention is achieved like this, for promoting a compound recipe thousand order ultramicro powder Chinese medicine for growth of animal, it is press row part by weight mixed preparing by multi-flavor thousand order superfine powder herbal medicine and antibacterial peptide to form: Radix Codonopsis 6-12 part, Radix Astragali 6-12 part, Poria 4-8 part, Semen Alpiniae Katsumadai 4-8 part, Rhizoma Atractylodis Macrocephalae 3-6 part, Massa Medicata Fermentata 2-4 part, Fructus Hordei Germinatus 2-4 part, Radix Glycyrrhizae 2-4 part; Antibacterial peptide 15-30 part.
For compound recipe thousand order ultramicro powder Chinese medicine promoting growth of animal and preparation method thereof, its method is: every taste Chinese medicine is first crossed 200-500 order, further drying, again low-temperature submicron powder be broken to 1000 orders by 20-40 object coarse powder, rear low temperature rapid draing, Crushing of Ultrafine, for subsequent use; Take according to each taste Chinese medicine number in prescription is enough, and take the antibacterial peptide of recipe quantity, add in blender together and stir 20-30 minute, mixing, packaging, to obtain final product.
Quality index is as follows:
1. each taste Chinese medicine fineness reaches 1000 orders (medium particle diameter d50 is no more than 12.5um);
2. antibacterial peptide is small-molecular peptides, and molecular weight is 4000-7000;
3. drug effect is comparatively used alone Chinese medicine or antibacterial peptide is effective, Chinese medicine and the potentiation of antibacterial peptide conbined usage tool;
4. preparation moisture content is less than 5%.
The tools such as its scope of application is: across-the-board regulation body negative and positive, promote growth of animal, enhancing immunity, disease preventing and treating, the raising price of deed and improve animal product quality, the burnt and growth retardation of the inappetence simultaneously caused animal Different types of etiopathogenises, the thin hair of body have significant therapeutic effect.
Composition principle:
Radix Codonopsis: property is sweet is flat; Return spleen, lung meridian.Tool invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.Be mainly used in deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
The Radix Astragali: property is sweet, tepor; Return lung, spleen, liver, kidney channel.Effect of tool invigorating QI to consolidate the body surface resistance, hidroschesis detoxification, granulation promoting, diuresis, detumescent.Be mainly used to the treatment deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst.
Poria: property is sweet, light, flat; GUIXIN, lung, spleen, kidney channel.Tool promoting diuresis to eliminate damp pathogen, spleen invigorating, effect of mind calming.Main in dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, has loose bowels.
Semen Alpiniae Katsumadai: acrid in the mouth, warm in nature; Return spleen, stomach warp.Tool warming middle-JIAO dampness, effect of circulation of qi promoting spleen invigorating.Be mainly used in the coldness and pain in the epigastrium of the cloudy stagnant taste of cold-damp, feeling of fullness is done swollen, and vomiting, has loose bowels, and food indigested food, expectorant Yu, explains malaria.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature; Return spleen, stomach warp.Tool invigorating the spleen and benefiting QI, effect of dampness diuretic.Be mainly used in deficiency-weakness of spleen-QI, spiritlessness and weakness, lack of appetite abdominal distention, large loose stool is thin, fluid-retention stagnating in the interior, dysuria etc.
Massa Medicata Fermentata: warm in nature, sweet in the mouth, pungent, nontoxic; Return spleen, stomach warp.Tool invigorating the spleen and regulating the stomach, the effect helped digestion in adjusting.Be mainly used in weakness of the spleen and stomach, retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, young stock food stagnation.
Fructus Hordei Germinatus: sweet in the mouth, property is put down; Return spleen, stomach warp.Effect of tool promoting digestion and removing stagnation.Be mainly used in food stagnation not disappear, abdominal distention is had loose bowels, and feel sick and tell, inappetence, milk smoulders.
Radix Glycyrrhizae: sweet in the mouth, property is put down; Return spleen, stomach, the heart, lung meridian.The invigorating middle warmer of tool QI invigorating, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, effect of coordinating the actions of various ingredients in a prescription.Be mainly used in asthenia lack of appetite, leanness yellowish complexion, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, carbuncle skin ulcer swells and ache.
Antibacterial peptide: antibacterial peptide is that the one produced through induction in organism has bioactive micromolecule polypeptide, and belong to biological product class, molecular weight is about 2000 ~ 7000, is made up of 20 ~ 60 amino acid residues.The polypeptide much with antibacterial action has been found at present in different animals tissue.Experiment proves that it has nonspecific lethal effect to antibacterial, fungus, protozoon and virus.
In prescription, Chinese medicine is with Radix Codonopsis, Radix Astragali principal agent, and Poria, Semen Alpiniae Katsumadai, the Rhizoma Atractylodis Macrocephalae are ministerial drug, and Massa Medicata Fermentata, Fructus Hordei Germinatus are adjuvant drug, and Radix Glycyrrhizae is for making medicine, and all medicines match, and jointly reaches effect of replenishing QI to invigorate the spleen, removing food stagnancy relieving dyspepsia.In prescription, antibacterial peptide conbined usage, not only expands indication, and improves the drug effect of Chinese medicine.The tools such as the present invention can be used for across-the-board regulation animal body negative and positive, promotes growth of animal, enhancing immunity, disease preventing and treating, the raising price of deed and improve animal product quality, the burnt and growth retardation of the inappetence simultaneously caused the various cause of disease of animal, the thin hair of body have significant therapeutic effect.
During use, this medicated powder stirred in feedstuff in 0.5 – 5.0 % ratio or dissolves in drinking-water, appoint poultry free choice feeding or drink; Also can feed by every kg body weight poultry 0.1-1g, one day 1-2 time; Invention formulation can add for a long time, has no adverse reaction.
Feature of the present invention is: medicine of the present invention is that pure Chinese medicine and biological preparation antibacterial peptide form, and formula is reasonable.Its combination principle is Chinese medicine " replenishing QI to invigorate the spleen, removing food stagnancy relieving dyspepsia ", and antibacterial peptide improves the immune level of animal body comprehensively.Above-mentioned Chinese medicine and antibacterial peptide compatibility, can across-the-board regulation animal body negative and positive, promote growth of animal, enhancing immunity, disease preventing and treating, the raising price of deed and improve animal product quality, the tool such as the burnt and growth retardation of the thin hair of, body depressed to animal appetite has significant therapeutic effect simultaneously.Curative effect is higher than simple Chinese medicine preparation or antimicrobial peptide preparation.Preparation adopts raw material Chinese medicine wide material sources, good drug efficacy, and medicine noresidue, has no side effect; Preparation is applied widely, and market prospect is good.
Detailed description of the invention
Below in conjunction with preferred embodiments, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
Prescription proportioning: Radix Codonopsis 12g, Radix Astragali 12g, Poria 8g, Semen Alpiniae Katsumadai 8g, Rhizoma Atractylodis Macrocephalae 6g, Massa Medicata Fermentata 4g, Fructus Hordei Germinatus 4g, Radix Glycyrrhizae 4g; Antibacterial peptide 30g.Above-mentioned each component is pressed quality of medicinal material standard test, after qualified, Chinese medicine powder is broken into ultra-micro powder, measure through laser particle automatic analyzer and reach 1000 orders, qualified for subsequent use; Weigh each taste micronizing Chinese medicine and antibacterial peptide mix homogeneously in proportion, subpackage, can obtain.
Embodiment 2
Prescription proportioning: Radix Codonopsis 12g, Radix Astragali 12g, Poria 4g, Semen Alpiniae Katsumadai 4g, Rhizoma Atractylodis Macrocephalae 3g, Massa Medicata Fermentata 4g, Fructus Hordei Germinatus 4g, Radix Glycyrrhizae 4g; Antibacterial peptide 25g.Above-mentioned each component is pressed quality of medicinal material standard test, after qualified, Chinese medicine powder is broken into ultra-micro powder, measure through laser particle automatic analyzer and reach 1000 orders, qualified for subsequent use; Weigh each taste micronizing Chinese medicine and antibacterial peptide mix homogeneously in proportion, subpackage, can obtain.
Embodiment 3
Prescription proportioning: Radix Codonopsis 12g, Radix Astragali 12g, Poria 8g, Semen Alpiniae Katsumadai 8g, Rhizoma Atractylodis Macrocephalae 6g, Massa Medicata Fermentata 2g, Fructus Hordei Germinatus 2g, Radix Glycyrrhizae 2g; Antibacterial peptide 27g.Above-mentioned each component is pressed quality of medicinal material standard test, after qualified, Chinese medicine powder is broken into ultra-micro powder, measure through laser particle automatic analyzer and reach 1000 orders, qualified for subsequent use; Weigh each taste micronizing Chinese medicine and antibacterial peptide mix homogeneously in proportion, subpackage, can obtain.
Embodiment 4
Prescription proportioning: Radix Codonopsis 12g, Radix Astragali 6g, Poria 5g, Semen Alpiniae Katsumadai 5g, Rhizoma Atractylodis Macrocephalae 6g, Massa Medicata Fermentata 4g, Fructus Hordei Germinatus 4g, Radix Glycyrrhizae 4g; Antibacterial peptide 24g.Above-mentioned each component is pressed quality of medicinal material standard test, after qualified, Chinese medicine powder is broken into ultra-micro powder, measure through laser particle automatic analyzer and reach 1000 orders, qualified for subsequent use; Weigh each taste micronizing Chinese medicine and antibacterial peptide mix homogeneously in proportion, subpackage, can obtain.
Embodiment 5
Prescription proportioning: Radix Codonopsis 6g, Radix Astragali 12g, Poria 4g, Semen Alpiniae Katsumadai 5g, Rhizoma Atractylodis Macrocephalae 6g, Massa Medicata Fermentata 4g, Fructus Hordei Germinatus 4g, Radix Glycyrrhizae 4g; Antibacterial peptide 23g.Above-mentioned each component is pressed quality of medicinal material standard test, after qualified, Chinese medicine powder is broken into ultra-micro powder, measure through laser particle automatic analyzer and reach 1000 orders, qualified for subsequent use; Weigh each taste micronizing Chinese medicine and antibacterial peptide mix homogeneously in proportion, subpackage, can obtain.
Embodiment 6
Prescription proportioning: Radix Codonopsis 12g, Radix Astragali 12g, Poria 8g, Semen Alpiniae Katsumadai 8g, Rhizoma Atractylodis Macrocephalae 6g, Massa Medicata Fermentata 4g, Fructus Hordei Germinatus 4g, Radix Glycyrrhizae 4g; Antibacterial peptide 15g.Above-mentioned each component is pressed quality of medicinal material standard test, after qualified, Chinese medicine powder is broken into ultra-micro powder, measure through laser particle automatic analyzer and reach 1000 orders, qualified for subsequent use; Weigh each taste micronizing Chinese medicine and antibacterial peptide mix homogeneously in proportion, subpackage, can obtain.
Embodiment 7
Prescription proportioning: Radix Codonopsis 12g, Radix Astragali 12g, Poria 8g, Semen Alpiniae Katsumadai 8g, Rhizoma Atractylodis Macrocephalae 6g, Massa Medicata Fermentata 4g, Fructus Hordei Germinatus 4g, Radix Glycyrrhizae 4g; Antibacterial peptide 20g.Above-mentioned each component is pressed quality of medicinal material standard test, after qualified, Chinese medicine powder is broken into ultra-micro powder, measure through laser particle automatic analyzer and reach 1000 orders, qualified for subsequent use; Weigh each taste micronizing Chinese medicine and antibacterial peptide mix homogeneously in proportion, subpackage, can obtain.
Embodiment 8
Radix Codonopsis 12g, Radix Astragali 12g, Poria 6g, Semen Alpiniae Katsumadai 6g, Rhizoma Atractylodis Macrocephalae 4g, Massa Medicata Fermentata 3g, Fructus Hordei Germinatus 3g, Radix Glycyrrhizae 3g; Antibacterial peptide 25g.Above-mentioned each component is pressed quality of medicinal material standard test, after qualified, Chinese medicine powder is broken into ultra-micro powder, measure through laser particle automatic analyzer and reach 1000 orders, qualified for subsequent use; Weigh each taste micronizing Chinese medicine and antibacterial peptide mix homogeneously in proportion, subpackage, can obtain.
apply effect of drugs of the present invention citing
Application example 1
This article draws from author: Liu Liheng
1, Suzhou
2, Qiu Guangzhong
2the article that (1. Agricultural University Of Jiangxi, 2. Ganzhou City Xumu Research Institute) delivers, content is as follows:
Title: thousand order ultra micro Chinese medicines urge long agent and compound preparation thereof to the pre-test of chicken growth-promoting effect
For a long time, people use antibiotic and chemical synthetic drug to make feed additive in a large number, improve animal and fowl fodder transformation efficiency, appetite stimulator, growth promoting effects to reach, and improve the object of Animal product quality and control livestock and poultry.As everyone knows, long-term a large amount of antibiotic and the chemical drugs of using easily causes pathogen to produce drug resistance, easily cause toxic and side effects and residual.Like this, not only reduce livestock products quality, infringement is produced to human health, causes environmental pollution simultaneously.So develop natural animal and plant active ingredient or other biological preparation substitute antibiotics and chemical drugs, to make feed additive for promoting growth imperative.This research utilizes natural plants active ingredient to make " long agent urged by Chinese medicine ", fermenting organism preparation " antibacterial peptide " and conbined usage thereof just and does feedstuff interpolation, urge long agent-olaquindox with traditional chemical dysentery relieving to contrast, improve the effect in chicken fertility performance, disease preventing and treating and routine blood indexes etc. to explore it.For this reason, we carry out this preliminary test in March, 2014 to May at Agricultural University Of Jiangxi's Animal Science And Technology Animal House.
materials and methods
1.1 test material
1.1.1 for examination animal
Test the blue egg-type cockerel in the sea selecting certain chicken house of Nanchang City to provide, after prerun, choose 150 plumages.Disconnected beak before test chicken test, and carry out prophylactic vaccination by normal procedure.Test is divided into 8 groups, often organizes 3 samples, the repetition of 10, each sample.
1.1.2 test instrument and medicine is supplied
Instrument: semi-automatic cellanalyzer, model: HF-3000; Electronic scale etc.
Medicine: " long agent urged by Chinese medicine " and " antibacterial peptide ", by Jiangxi nuclear industry Jin Pin Bioceuticals Inc. pilot production product, lot number is respectively: 20140202 and 2013101; " olaquindox ", Hubei manufacturer production, product batch number: 130801.All medicines are through checking the requirement that all conforms with the regulations.
1.1.3 daily ration is tested
In test point two stages, the first stage adopts autogamy chicken perfect compound feed (preliminary trial period and test first 20 days), and second stage is chicken perfect compound feed in autogamy (testing latter 20 days), and feedstuff does not add any medicine beyond any trial drug.Product analysis of components guarantee value is as follows in table 1.
Daily ration analysis of components guarantee value (%) tested by table 1
Table 1 Test dietary component analysisto ensurevalue(%)
Energy unit: kcal/kg
1.1.4 grouping is tested
This test adopts between single-factor group compares design, by prerun 10d(0-10d) after chickling weigh, be divided into 8 groups at random, often organize 3 samples, the repetition of 10, each sample.1 blank group (not medication) is established in test; 4 test group (medication).Test grouping and medication design are shown in as following table 2
Table 2 tests grouping and medication table
Unit: ppm
1.2 test method
1.2.1 the preparation of test group feedstuff
On the basis that each group of Diet Formula is identical, test group is added respectively by upper medicine administered to bring out the cold thing addition by relative medicine perfect compound feed, and matched group does not add any medicine.
1.2.2 feeding and management
Test chicken is taked to raise in cages, omnidistance free choice feeding, and before test, follow procedure carries out vaccination work, and column home, apparatus carry out strict sterilization, clear up feces in time, keeps column home sanitation and hygiene and peace and quiet.Disease occurs will not treat, dead chicken is weighed in time and Ti removes feed consumption, and records mortality rate.
pilot project
1.3.1 weightening finish
The formal test of test chicken 11 age in days takes each group of chicken individual weight when starting, and claims individual weight 1 time every 20d later, and to nominal individual weight at the end of the 40d of interval 3 times, com-parison and analysis respectively organizes rate of body weight gain difference.
1.3.2 feed consumption
Accurately take every day and record each group of feed intake, during off-test, respectively organizing feedstuff-meat ratio difference.
1.3.3 health status
Every day observes and record, does not take Drug therapy to morbidity chicken, occur death then Ti except its feed consumption, and the survival rate difference that com-parison and analysis is respectively organized.
1.3.4 shape and appearance situation of change
Main detection respectively organizes chicken feather color development, mental status and feces situation, its diversity of com-parison and analysis.
1.3.5 routine blood indexes measures
During off-test, Mei Zu Sui machine extract 10 adopt whole blood do routine blood test measure, 20 items index, the routine blood indexes diversity between each group of com-parison and analysis.
statistical analysis
Diversity between each group compares employing statistical software-DAEMON Tools Lite and carries out analytic statistics, more each group difference significance.
results and analysis
2.1 daily gain results
table 3 is group daily gain and diversity comparison sheet respectively
unit: g/ plumage
Note: in table, data mark different alphabet and are shown with remarkable star difference (P<0.05).
As seen from Table 3, just each group difference of starting weight is not remarkable in test.From the net gain of 40d average individual, all test group are all apparently higher than matched group, and difference all significantly (P<0.05).Drug combination group (test 4) is better than 3 folk prescription medication groups, but difference is not significantly (P≤0.05).
feedstuff-meat ratio and survival results are shown in as following table 4
Table 4 test chicken survival rate and feedstuff-meat ratio information slip
unit: kg
As seen from Table 4, the feedstuff-meat ratio of all test group comparatively matched group have reduce in various degree, to test 4(drug combination group) best, reduce material consumption 48.9 %, test 1 group (olaquindox group) minimum, reduce by 18.6 %.Dead 2 plumages of death condition matched group, survival rate 93.3%; Test each group and all do not occur death, illustrate that various medicine all can have preventive and therapeutic effect to Animal diseases.
visual inspection result
Test group chicken feather light, figure is solid and plentiful.The relative low in glossiness of matched group chicken feather, figure is loose.
disease observed result
All test chickens dysentery phenomenon of all significantly not having loose bowels in process of the test occurs, and does not have to have during the matched group chicken of medication dysentery of having loose bowels to produce, and has influence on the growth of chicken, but also causes 2 plumages dead due to disease.
routine blood test testing result is shown in as following table 5
Measurement result shows, the many indicator differences of routine blood test are not obvious, do not reach significant difference (P≤0.05), comprise: total white blood cells (WBC), lymphocyte ratios (LYM%), lymphocyte (LYM#), Erythrocytes (RBC), hemoglobin (HGB), packed cell volume (HCT), mean corpuscular volume (MCV), content of hemoglobin (MCH), hemoglobin concentration (MCHC), Erythrocyte hemoglobin distribution width (RDW-SD), total number of blood platelet (PLT), mean platelet volume (MPV), MPW (PDW), thrombocytocrit (PCT) and platelet maxicell ratio (P-LCR), all do not list in following table.There is significant difference index and see the following form 5:
table 5 test chicken routine blood test testing result table
Note: in table, data mark different alphabet and are shown with remarkable star difference (P<0.05).
Result shows, intermediate cell (MID#), granulocyte (GRAN#), between intermediate cell ratio (MID) and granulocyte ratio (GRAN) group, deposit significant difference, each test group is apparently higher than matched group (P<0.05), to test 4 groups (drug combination groups) for the highest between test group, there were significant differences (P<0.05) for part index number and other test group, illustrates that Chinese medicine and antibacterial peptide drug combination can improve body health level better.
discuss
3.1 from test weightening finish result, and all test group exceed matched group all to some extent, all reach significant difference (P<0.05), illustrates that all trial drugs have facilitation to chicken growth.Compare between test group, test 4 groups of (drug combination group) effects best, improve 25% than matched group, test 2 groups (long agent urged by Chinese medicine) to take second place, improve 18.3%, test 1 group (olaquindox) and improve 16.8%, but difference remarkable (P >=0.05) between three folk prescription medication groups.The result shows, long agent urged by antibacterial peptide, Chinese medicine, olaquindox has good facilitation to chicken growth, but long agent urged by Chinese medicine and antibacterial peptide drug combination has obvious potentiation.
3.2 from the comparative analysis of test feed consumption, four test group can significantly reduce test chicken feedstuff-meat ratio to some extent, and be up to test 4 groups (drug combination group), feedstuff-meat ratio reduction rate is up to 48.9%, minimum is test 1 group (olaquindox group), reduces by 18.6 %.This result also illustrates, long agent urged by interpolation antibacterial peptide, Chinese medicine, olaquindox significantly can reduce chicken growth feedstuff-meat ratio, but long agent urged by Chinese medicine and antibacterial peptide polypharmacy has obvious potentiation.
3.3 from routine analysis of blood, although most blood ceremetres does not have notable difference, found that, each test group chicken intermediate cell (MID#) and granulocyte (GRAN#) and account for ratio of blood and be all significantly higher than matched group.Intermediate cell and granulocyte are as the important indicator of the nonspecific immunity of animal, antibacterial peptide is described, long agent urged by Chinese medicine and olaquindox to a certain degree can improve the innate immune activity of chicken, strengthen chicken to the resistance of disease, but part index number polypharmacy and folk prescription medication have notable difference, its value is higher, illustrates that Chinese medicine and antibacterial peptide conbined usage can improve chicken health level.
3.4 from experimental observation result, and each test group mental status is good, and seldom have dysentery phenomenon of having loose bowels to occur, duration of test does not have chicken dead, not medication matched group then poor stability, and mortality rate is high simultaneously, and survival rate is 93.3%.The result shows, antibacterial peptide, urge long dysentery relieving to fall apart and olaquindox can prevent and treat the generation of chicken disease, improve incubation rate.
brief summary
Today of stricter restriction use is subject at olaquindox class chemical drugs, long agent urged by the pure natural medical Chinese medicine of this test and antibacterial peptide has good growth-promoting effect and disease preventing and treating effect, good succedaneum can be become, but long agent urged by Chinese medicine and antibacterial peptide coupling has better growth-promoting effect, its Application and Development will have wide market prospect.
Application example 2
This article draws from author: Suzhou
1, Qiu Guangzhong
1, leaf bright cloud
2, Li Jingyao
1, Qiu Yunguang
1, Japanese plum put down
1, Zhong Yunping
1, Guo Lirong
1the article that (1. Ganzhou City Xumu Research Institute, 2. Ganzhou City's agricultural use Foreign Investment Office) delivers, content is as follows:
Title: feedstuff adds " herbal mixture urgees long agent " and to feed the pre-test of fattening pig effect
For a long time, people use antibiotic and chemical synthetic drug to make feed additive in a large number, improve animal and fowl fodder transformation efficiency, appetite stimulator, growth promoting effects to reach, and improve the object of Animal product quality and control livestock and poultry.As everyone knows, antibiotic and chemical medicine is used easily to cause pathogen produce drug resistance, easily generation toxic and side effects and remain for a long time in a large number.Like this, not only reduce livestock products quality, infringement is produced to human health, meanwhile, easily causes environmental pollution.So developing natural animal and plant active ingredient substitute antibiotics and chemical medicine, to make feed additive imperative.This research utilizes superfine powder natural Chinese medicine and biological preparation " antibacterial peptide " to make compound recipe feed additive for promoting growth just, is improving the effect in Performance of Finishing Pigs and disease preventing and treating etc. to explore it.For this reason, we carried out " herbal mixture urgees long agent " and to have fed fattening pig preliminary test on kind pig farm, Ganzhou City Xumu Research Institute 2013 on March 17, to May 17.
1 materials and methods
1.1 test material
1.1.1 for examination animal
Health Du × length × Dasanyuan hybridization the piglet 32 of kind pig farm, Ganzhou City Xumu Research Institute average individual heavily about 15kg is selected in test.
1.1.2 " herbal mixture urgees long agent "
By Jiangxi, nuclear industry Rui Feng Bioceuticals Inc. provides trial target, is by thousand order ultrafine powder traditional Chinese medicines and antibacterial peptide formulated compounding powder by a certain percentage, lot number 12102101.
1.1.3 daily ration is tested
The little pig feed (suitable 15 ~ 30kg) adopting Ganzhou Jin Gan animal husbandry Institute of Development Studies to produce, middle pig feed (suitable 30 ~ 60kg).Product analysis of components guarantee value is in table 1.
Daily ration analysis of components guarantee value (%) tested by table 1
1.1.4 EXPERIMENTAL DESIGN
This test adopts between single-factor group compares design, and weighed by the piglet after prerun 7d, be divided into four groups at random, often organize 8, wherein test group is I, II, III group, and the IVth group is matched group, and each group male and female ratio is the same, and body weight is close with age in days.
1.2 test method
1.2.1 the preparation of " herbal mixture urgees long agent "
On the basis that each group of Diet Formula is identical, test I, II, III group and add " herbal mixture urgees long agent " 0.3%, 0.6%, 0.9% respectively in perfect compound feed, matched group does not add any medicine.
1.2.2 feeding and management
Stable breeding, omnidistance free choice feeding, drinking-water.Vaccination work is carried out by immune programme for children before test.Column home, apparatus carry out strict sterilization, clear up feces in time, keep column home sanitation and hygiene and peace and quiet.Disease occurs treat in time, experimental period, does not eliminate pig.
1.3 observation projects
1.3.1 weightening finish
Take each group of 1d individual weight when formal test starts, later every 30d claims individual weight 1 time, to nominal individual weight at the end of 60d 3 times.
1.3.2 feed consumption
Accurately take every day and record each group of feed intake.
1.3.3 health status
Every day observes and record, takes Drug therapy to morbidity pig.
1.3.4 shape and appearance situation of change
Main detection respectively organizes the skin of pig and the situation of hair.
2 results and analysis
2.1 weighing results
table 2 takes the heavy unit of average individual at every turn: kg/ head
As seen from Table 2, just each group difference of starting weight is not remarkable in test.From the net gain of 60d average individual, I, II group apparently higher than III, IV group.
2.2 feed consumptions and consumption " herbal mixture urgees long agent " result
table 3 tests 60 days feed consumptions, feed-weight ratio situation unit: kg
As seen from Table 3, test the feed-weight ratio comparatively matched group reduction by 10.3% of I group, the feed-weight ratio testing II, III group is close with matched group.
2.3 fur observed results
Test group swinery color of the leather is ruddy, gloss, and figure is solid and plentiful.Matched group swinery color of the leather is paler, and hair is longer, and matt, figure is loose.
2.4 disease observed results
Because test 7d in early stage adopts restriction to feed, change free choice feeding into after 7d, all there is dyspepsia, have loose bowels in matched group, and a dyspepsia, phenomenon of having loose bowels do not appear in three test group, and this illustrates that " herbal mixture urgees long agent " has stronger anti-diarrhea effect.
3 discuss
3.1 from result of the test, tests I group of effect best.Meanwhile, it is minimum to test I group of consumption " herbal mixture urgees long agent ", and cost is minimum, therefore tests I group of Effectiveness and benefit best.
3.2 antidiarrheal effects to " herbal mixture urgees long agent ", await studying further from now on.
3.3 these tests just PRELIMINARY RESULTS, awaits pilot scale to the representativeness of result and repeatability and verifies further, also await research to its mechanism of action.
application example 3
Address: Jiangxi high peace Liu Youli plant
In November, 2012, Jiangxi high peace Liu Youli plant outsourcing nursery pig 412, average weight is 12kg, and it is always steady to enter behind hurdle piglet in 5 days, after reseed pig blue-ear disease vaccine.There are several to occur symptom of diarrhea in swinery after inoculation, within 3 days, involve rapidly full group afterwards, be diagnosed as porcine epizootic diarrhea through test in laboratory.Adopt antibiotics medicine to treat after morbidity, swinery loses and is clearly better, and occurs that dewatering symptom pig is dead rapidly.Invention formulation taken by rear drinking-water, the average about 5g of day dosing powder 2kg(every), take medicine one week, result shows, violent " watery diarrhea " that adopt invention formulation control porcine epizootic diarrhea to cause has obvious curative effects, and morbidity diarrhea of pigs symptom is eliminated, dewatering symptom improves, and appetite is recovered, and the mental status is clearly better, feed intake increases, and feces takes a turn for the better, and skin is ruddy, breathe steadily, symptom disappears substantially, and cure rate reaches 98%, without secondary disease or complication.After use a course for the treatment of (15 days) every other month, swinery is until deliver all quite stables for sale, and swinery growth performance recovers normal.
application example 4
Address: Jiangxi is in Dou Yang state dragon chicken farm
1900 plumage 25 age in days laying chickling are raised, on December 3rd, 2012 in Dou Yang state dragon chicken farm in Jiangxi, start have part to draw white or yellow green loose stool in chicken group, stick with paste in anus, god is slow-witted for hair pine, and wing is sagging, the high heat of sick chicken performance, appetite reduces, thirsty, accelerated breathing, sagging, slow-witted vertical, drowsiness, fine hair is fluffy and disorderly.Sometimes see that purulent conjunctivitis causes a face adhesion, head swelling.Chronic person's dysentery, blood stool, arthroncus.Pathological change is whole body pulmonary congestion edema, lymph node edema, and whole hepatomegaly has the downright bad point of lark, and heart hat fat is hemorrhage; Intestinal particularly duodenum has hemorrhagic inflammation, and there is petechia etc. on the surface of intracardiac, adventitia and kidney, is the chicken paratyphoid fever caused by Salmonella gallinarum after testing.After morbidity, invention formulation taken by full group's drinking-water, and day dosing powder 10kg(average every plumage about 0.5 g), does not take other medicines, after taking medicine one week, except the 16 ptilosis fowl death that performance clinical severity is serious, other equal temperature recovery is normal, appetite is recovered, and the mental status is clearly better, and feed intake increases, feces is all normal, symptom disappears substantially, and cure rate reaches 99%, without secondary disease or complication, after always half amount use invention formulation, chicken grows fine.
application example 5
Address: Jiangxi week Xiajiang Ma Bu Yang Chang
On August 10th, 2013, Ma Bu sheep place, the Xiajiang, Jiangxi is raised has 150 remainders to vary in size lamb, wherein has 30 bellwether lamb phase secondary diseases, and successively dead 6, sick sheep performance draws dysentery, Excreta in yellow or yellow-white; Depressed, the sleeping ground of loss of appetite, spirit does not rise; Part sheep stream nose liquid, performance dewatering symptom; Through cuing open inspection, pathological change is lymph nodes of body as a whole edema, has intestinal to have catarrhal inflammation, and intestinal villus film shortens or disappears.Be the lamb dysentery that escherichia coli cause through Laboratory Diagnosed.Dissolve in a small amount of water with invention formulation after morbidity and feed, the average every bellwether 20g of day dosing, a point secondary carries out.After taking medicine 5 days, result shows, invention formulation treatment is adopted to have obvious curative effects, after medication, the 2nd day morbidity sheep appetite is recovered, the mental status is clearly better, within 4th day, symptom of diarrhea all disappears, and feces is normal, does not occur death after medication, cure rate reaches 100%, and without secondary disease or complication.Within 5 days, continue afterwards partly to measure medication for a long time, by the observation of 30 days by a definite date, the not morbidity of test sheep health, grew fine.
application example 6
The pure Chinese medicine of one of Jiangxi nuclear industry Rui Feng Bioceuticals Inc. of herbal mixture growth promoter system of the present invention trial production and antibacterial peptide is composite forms preparation, it can improve laying rate, significantly improves Egg Quality, and its major advantage is as follows:
1 natural Chinese medicines and biological product antibacterial peptide is composite forms, without violated composition, without drug resistance, no drug residue, without three-induced effect, safe and reliable.
2 raising laying hen 30 days institutes lay eggs and the results are shown in following table:
3
4 significantly can change egg quality, particularly yelk bepaint.
4.1 eggshell strengths improve 15.021% than matched group, significant difference (P<0.05).
4.2 yolk colors are higher than matched group by 5.128, and difference extremely significantly (P<0.01).
4.3 egg yolk weights improve 11.705%.
4.4 other indicator differences are not obvious.
4 improve laying rate, and laying rate improves more than 5%.
Claims (4)
1. one kind for compound recipe thousand order ultramicro powder Chinese medicine promoting growth of animal and preparation method thereof, it is characterized in that pressing row part by weight mixed preparing by multi-flavor thousand order ultrafine powder traditional Chinese medicine and antibacterial peptide forms: Radix Codonopsis 6-12 part, Radix Astragali 6-12 part, Poria 4-8 part, Semen Alpiniae Katsumadai 4-8 part, Rhizoma Atractylodis Macrocephalae 3-6 part, Massa Medicata Fermentata 2-4 part, Fructus Hordei Germinatus 2-4 part, Radix Glycyrrhizae 2-4 part; Antibacterial peptide 15-30 part.
2. one kind according to claim 1 for compound recipe thousand order ultramicro powder Chinese medicine promoting growth of animal and preparation method thereof, it is characterized in that its method is: every taste Chinese medicine is first crossed 200-500 order, further drying, again low-temperature submicron powder be broken to 1000 orders by 20-40 object coarse powder, rear low temperature rapid draing, Crushing of Ultrafine, for subsequent use; Take according to each taste Chinese medicine number in prescription is enough, and take the antibacterial peptide of recipe quantity, add in blender together and stir 20-30 minute, mixing, packaging, to obtain final product.
3. according to claim 1 or 2 for promoting a compound recipe thousand order ultramicro powder Chinese medicine for growth of animal, it is characterized in that its quality index is as follows:
1. each taste Chinese medicine fineness reaches 1000 orders (medium particle diameter d50 is no more than 12.5um);
2. antibacterial peptide is small-molecular peptides, and molecular weight is 4000-7000;
3. drug effect is comparatively used alone Chinese medicine or antibacterial peptide is effective, Chinese medicine and the potentiation of antibacterial peptide conbined usage tool;
4. preparation moisture content is less than 5%.
4. one kind according to claim 1 and 2 for promoting the compound recipe thousand order ultramicro powder Chinese medicine of growth of animal, it is characterized in that the scope of application is as follows: across-the-board regulation body negative and positive, promote growth of animal, enhancing immunity, disease preventing and treating, the raising price of deed and improve animal product quality, the tools such as the burnt and growth retardation of the inappetence simultaneously caused animal Different types of etiopathogenises, the thin hair of body have significant therapeutic effect.
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| CN107929610A (en) * | 2017-12-19 | 2018-04-20 | 四川农业大学 | A kind of Chinese medicine preparation and preparation method for being used to accelerate growth of animal and strengthen its constitution |
| CN110720630A (en) * | 2018-12-29 | 2020-01-24 | 瑞普（天津）生物药业有限公司 | Nutritional composition for relieving adenofibromyositis and gastritis symptoms |
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