CN102239972B - Traditional Chinese medicine feed additive used to improve immunity and resist parasitic infection of weaned piglets and preparation and use method thereof - Google Patents
Traditional Chinese medicine feed additive used to improve immunity and resist parasitic infection of weaned piglets and preparation and use method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine feed additive used to improve immunity and resist parasitic infection of weaned piglets. The traditional Chinese medicine feed additive is composed of the following traditional Chinese medicine raw materials: Codonopsis, Atractylodes, Poria cocos, yam, Astragalus, lotus seed, fried lentils, fried barley, Atractylis, dried tangerine peel, Polygonum, Ligustrum lucidum, Eclipta, Epimedium, Medicated Leaven, melanoidin malt, Rhizoma Dryoteris Crassirhizmae, fried betelnut, pumpkin seed, dandelion, purslane, Isatidis and licorice. The traditional Chinese medicine feed additive provided by the invention has the advantages of simple preparation process, low price and no any toxic and side effects, and can improve the immunity, prevent infectious diseases and enhance the resistance to pathogenic microorganisms and parasites of the weaned piglets, and improve the quality and yield of pig products.
Description
Technical field
The present invention relates to a kind of Chinese herbal feed additive, be used to strengthen the physique of weanling pig, improve immunity and anti-parasitic-infectious, belong to medical technical field.
Background technology
In China's pig industry flourish today, the popular ten minutes of swine disease is serious.Chemicalses such as antibiotic remain the first-selection that is used to prevent and treat infectious disease and parasitic disease.This not only causes the appearance of a large amount of drug-fast bacterias, worm strain; And cause chemicals residual in pork and products thereof; Bring very big infringement for public health and food security, more do not meet the food consumption trend of people's " high-quality, low residual, green non-pollution of medicine ".The consumption that livestock products will satisfy people requires just must seek a kind of safe production model, is first to be vital link and raise.This shows, seek a kind of not only safe and effective but also alternative antibiotic medicine seems particularly important.The immunity function of animal body is the important force that microorganism and parasitic infection, maintenance and recovery body normal physiological function were resisted and removed to body.In present intensive pig production process, the prevention of eqpidemic disease is still through the method for vaccinate, anti-parasitic-infectiously then mainly still relies on chemical anthelmintic.The anti parasitic effect of the immunity of vaccine and medicine is directly connected to the pig farm eqpidemic disease and takes place and economic benefit; In the life process of pig, the eqpidemic disease pressure that weanling piglet faces is very big, and in order to keep function of immune system, to guarantee to improve immunity, nutrition is decisive factor.Because Chinese herbal medicine has the dual-use function of nutrition and health care, the immune level and anti-parasitic-infectious that uses the Chinese herbal medicine immunopotentiator to improve body in the livestock and poultry cultivation receives common concern.
Chinese medicine because of its have aboundresources, effect extensively, treat both principal and secondary aspect of disease, safety and low toxicity, cheap, be difficult for producing extremely people's favor of advantage such as drug resistance.Do not see as yet at present with Chinese medicine as feed addictive and to improve the public reported of immunity and medicine for antiparasitic infection in order to strengthen piglet physique.
Summary of the invention
The objective of the invention is to weanling pig pathogenic factor and existing antibiotic therapy disadvantage; A kind of be used to improve weanling pig immunity and anti-parasitic-infectious Chinese herbal feed additive are provided; Improve weanling pig immunity; The generation of keeping off infection property disease strengthens invasive organism and parasitic resistance.
For realizing this purpose, technical solution of the present invention is following:
A kind ofly be used to improve weanling pig immunity and anti-parasitic-infectious Chinese herbal feed additive, form: Radix Codonopsis 30-90G, bighead atractylodes rhizome 10-30G, Fu a kind of reed mentioned in ancient books 30-90G, Chinese yam 30-90G, Radix Astragali 30-90G, lotus seeds 10-30G, stir-fried kidney beans 10-30G, fry heart of a lotus seed benevolence 10-30G, rhizoma atractylodis 10-30G, dried orange peel 10-30G, fleece-flower root 30-90G, fruit of glossy privet 10-30G, Eclipta prostrata 10-30G, barrenwort 30-90G, stir-baked MASSA FERMENTATA MEDICI-NALIS 30-90G, melanoidin malt 30-90G, rhizome of cyrtomium 15-45G, Semen Arecae (parched) 10-30G, pumpkin seeds 20-60G, dandelion 30-90G, purslane 30-90G, isatis root 20-60G and Radix Glycyrrhizae 6-18G by the following weight Chinese medicinal raw materials.
As preferred version of the present invention, form: Radix Codonopsis 60G, bighead atractylodes rhizome 20G, Fu a kind of reed mentioned in ancient books 60G, Chinese yam 60G, Radix Astragali 60G, lotus seeds 20G, stir-fried kidney beans 20G, stir-fry heart of a lotus seed benevolence 20G, rhizoma atractylodis 20G, dried orange peel 20G, fleece-flower root 60G, fruit of glossy privet 20G, Eclipta prostrata 20G, barrenwort 60G, stir-baked MASSA FERMENTATA MEDICI-NALIS 60G, melanoidin malt 60G, rhizome of cyrtomium 20G, Semen Arecae (parched) 20G, pumpkin seeds 40G, dandelion 60G, purslane 60G, isatis root 40G and Radix Glycyrrhizae 12G by the following weight Chinese medicinal raw materials.
A kind of preparation method who is used to improve weanling pig immunity and anti-parasitic-infectious Chinese herbal feed additive comprises the steps:
1. prepare burden: take by weighing Chinese medicine material by proportioning;
2. screening: remove the impurity in the Chinese medicine material;
3. drying and crushing: with the Chinese medicine material drying and crushing, cross 80 mesh sieves, mix, powder;
4. packing.
A kind of method for using that is used to improve weanling pig immunity and anti-parasitic-infectious Chinese herbal feed additive is characterized in described Chinese herbal feed additive is made an addition in the feed by 2wt%, and 1 month is a course of treatment, serve on 2 courses of treatment.
The present invention mainly sets upright the theory of getting rid of evils according to the traditional Chinese medical science, and theory of traditional Chinese medical science thinks that positive unsaturated vapor is the internal cause that disease takes place, and perverse trend is the external cause that disease takes place.Piglet itself is weakness of the spleen and the stomach, insufficiency of primordial QI, and the wean back is owing to flip-floies such as environment and diet, and the body transporting and transforming function of the spleen and stomach is dull, and liver kidney yin YANG deficiency causes disease and evil to be taken advantage of a weak point, and is prone to send out communicable disease, disease of digestive tract and a parasitic disease.To the cause of disease, drug prescription is followed and is replenished qi to invigorate the spleen, nourishing liver and kidney, eliminating stagnated food to destroy intestinal worms fundamentum, strengthens piglet physique; Characteristics according to the piglet growth stage of development are aided with Chinese medicine clearing heat and detoxicating, regulating QI to expel dampness.
Principle is following:
Radix Codonopsis tonifying middle-Jiao and Qi in the medicament, promote the production of body fluid and nourish blood, modern pharmacological research confirms: Radix Codonopsis has excitation to nervous system, but the enhancing body resistance; Can bring high blood pressure down, increase hemochrome; Enhancing body immunity, the activity of raising superoxide dismutase; Strengthen the ability of eliminating free radical; Has the effect of regulating gastrointestinal motility, antiulcer, gastric acid inhibitory secretion, reducing pepsin activity.The bighead atractylodes rhizome is invigorated the spleen and benefited qi, eliminating dampness Li Shui, and modern pharmacological research confirms: the bighead atractylodes rhizome has adjustment gastrointestinal motility function; The enhancing body immunologic function significantly strengthens the ability of leukocytes phagocytic staphylococcus aureus; Anti-stress, have antifatigue and the effect that strengthens adrenal cortex function; Strengthen hematopoiesis function, promote the mouse red blood cell hemoposieis.The Poria cocos clearing damp and promoting diuresis, invigorating the spleen, modern pharmacological research confirms: antitumor action, pachymaran has inhibitory action to murine sarcoma S180, pachymaran F1 and H11, the obvious antitumor activity of tool; Immunological enhancement, pachyman has humidification to the immunologic function of normal and tumor-bearing mice, can strengthen macrophage phagocytosis of mice.The Chinese yam invigorating spleen and reinforcing stomach, nourishing kidney and replenishing pneuma, beneficial lung cough-relieving, modern pharmacological research confirms: Chinese yam contains materials such as amylase, polyphenol oxidase, helps the taste digestion and absorption function; Chinese yam contains various nutrients, and strong body is arranged, the effect of nourishing kidney and replenishing pneuma; Chinese yam contains saponin, lymphatic temperament, has lubricatedly, and the effect of moistening can beneficial lung qi, supports lung yin, the treatment deficiency syndrome of the lung phlegm disease of chronic cough of coughing.Radix Astragali tonifying Qi and lifting yang. benefit is defended solid table. and modern medicine study shows that the enhancing non-specific immune function is arranged, and the Radix Astragali can significantly increase the total white blood cells in the blood, promotes the phagocytic function and the sterilizing ability of neutrophil leucocyte and macrophage; Strengthen specific immune function, the Radix Astragali can obviously strengthen cellular immunity, promotes the lymphocyte transformation that PHA, COnA, PWM (dyers' grapes) cause; The erythrocytic specific volume that raises increases RBC number, and the astragalus polyose erythrocytic specific volume of normal rat that can raise increases RBC number.Five medicines share to monarch drug in a prescription and play the gas that strengthens the spleen and stomach altogether.Being equipped with the stir-fried kidney beans invigorating the spleen for eliminating dampness relieves summer heat; Fry the invigorating the spleen of heart of a lotus seed benevolence clearing damp and promoting diuresis, have antitumor and enhance immunity power and antiinflammatory action, the immunity of coix seed oil pair cell, humoral immunity have facilitation; The lotus seeds reinforcing spleen and kidney nourishes heart; Rhizoma atractylodis are drying damp and strengthening spleen, and expelling wind and clearing away cold can be adjusted the gastrointestinal motility function, and antiulcer protects the liver, antibacterial; Eliminating dampness during dried orange peel is regulated the flow of vital energy and transferred, five medicines share auxiliary monarch drug in a prescription, but both invigorating the spleen, again can excreting dampness and antidiarrheal.Be equipped with the strengthening the bones and muscles of fleece-flower root filling liver kidney benefiting essence-blood, its effect of modern pharmacological research has the promotion hematopoiesis function, improves body's immunity, reducing blood lipid, and antiatherosclerosis protects the liver etc.; The fruit of glossy privet has tonified the liver and kidney, and its pharmacological action of modern study has raise immunity, and the rising peripheral leukocytes strengthens reticuloendothelial system phagocytic activity, strengthens the effect of cellular immunity and humoral immunity; The hepatic injury that Eclipta prostrata liver-nourishing kidney-boosting, modern pharmacological research effect have pair carbon tetrachloride to cause all has protective effect, can obviously strengthen nospecific immunity and cellular immune function and significantly promote T, bone-marrow-derived lymphocyte increment; The strengthening the bones and muscles of barrenwort kidney-replenishing, modern study is found the effect of its antibody horizontal that is significantly improved, and can strengthen the phagocytic activity of reticuloendothelial system, four medicines share and play nourishing liver and kidney effect altogether.Be equipped with stir-baked MASSA FERMENTATA MEDICI-NALIS, melanoidin malt and play invigorating the spleen, food digesting action altogether, wherein stir-baked MASSA FERMENTATA MEDICI-NALIS, melanoidin malt its contain multiple digestive ferment, also contain saccharomycete, B family vitamin, improve a poor appetite, promote digestion.Assistant is clearing heat and detoxicating with rhizome of cyrtomium, end dysentery, desinsection, and pharmacological research has the effect of resisting pathogenic microbes; The Semen Arecae (parched) long-pending anthelmintic action that disappears, arecaline is effective anthelmintic ingredient, and pork tapeworm is had stronger paralysis effect, and each one of full worm is all paralysed; Pumpkin seeds and betel nut have been used synergy.Assistant is clearing heat and detoxicating with dandelion, and modern study finds that it has the resisting pathogenic microbes effect, can significantly improve human peripheral lymphocyte blast transformation rate; Purslane clearing heat and promoting diuresis, removing toxicity for detumescence, anti-inflammatory; Antibacterial action; The inhibitory action that Escherichia coli, proteus, shigella dysenteriae, typhoid fever, paratyphosum Bacterium is had height; Staphylococcus aureus, fungi, tubercle bacillus also there are inhibitory action in various degree, Pseudomonas aeruginosa is had slight inhibitory action; Isatis root is clearing heat and detoxicating, and three medicines share, and communicable disease takes place the prevention piglet.Radix Glycyrrhizae coordinating the drug actions of a prescription, relieving spasm to stop pain and detoxify are for making medicine.
Compared with prior art; The present invention has following beneficial effect: the present invention is based on the traditional Chinese medical science to pathogenetic understanding of weanling pig and principle of reatment; Follow the research to the Chinese medicine function of drug matching principle and modern pharmacology, in conjunction with residing environment of intensive pig production field weanling pig and growth characteristic thereof, the medicament that natural Chinese medicinal herb is formed is as the feed addictive weanling pig of feeding; Physique to strengthening piglet improves immunity of organisms; Strengthen anti-parasitic-infectious and, improve the live pig marketing time and the rate of animals delivered to the slaughter-house, reduce the generation of parasitic disease and improve meat quality measuring good effect the resistance of invasive organism.Used Chinese herbal medicine in its prescription, to dull behind the weaned piglet owing to transporting and transforming function of the spleen and stomach, liver kidney yin YANG deficiency; Add flip-floies such as environment and diet again; Immunity degradation causes the generation of pathogenic microorganism invasion and attack and parasitic disease, plays strengthening the spleen and replenishing qi; Build up health, improve immunity and kill parasitic effect.Used Chinese herbal medicine is cheap common drug among the present invention; Being made into additive for feed for piglets takes; Substituting antibiotic and chemical synthesis anthelmintic uses; Without any side effects, obtain high economic benefit with lower input, and for reducing the residual some effective that provides of antibiotic and chemicals in the animality goods.
The specific embodiment
Below through concrete embodiment technical scheme of the present invention is further described, but do not limit protection scope of the present invention with this.
Embodiment 1
A kind ofly be used to improve weanling pig immunity and anti-parasitic-infectious Chinese herbal feed additive, form: Radix Codonopsis 60G, bighead atractylodes rhizome 20G, Fu a kind of reed mentioned in ancient books 60G, Chinese yam 60G, Radix Astragali 60G, lotus seeds 20G, stir-fried kidney beans 20G, fry heart of a lotus seed benevolence 20G, rhizoma atractylodis 20G, dried orange peel 20G, fleece-flower root 60G, fruit of glossy privet 20G, Eclipta prostrata 20G, barrenwort 60G, stir-baked MASSA FERMENTATA MEDICI-NALIS 60G, melanoidin malt 60G, rhizome of cyrtomium 20G, Semen Arecae (parched) 20G, pumpkin seeds 40G, dandelion 60G, purslane 60G, isatis root 40G and Radix Glycyrrhizae 12G by the following weight Chinese medicinal raw materials.
A kind of preparation method who is used to improve weanling pig immunity and anti-parasitic-infectious Chinese herbal feed additive comprises the steps: 1. to prepare burden: take by weighing Chinese medicine material by said ratio; 2. screening: remove the impurity in the Chinese medicine material; 3. drying and crushing: with the Chinese medicine material drying and crushing, cross 80 mesh sieves, be mixed into powder; 4. medicament is processed in packing.
Embodiment 2
A kind ofly be used to improve weanling pig immunity and anti-parasitic-infectious Chinese herbal feed additive, form: Radix Codonopsis 30G, bighead atractylodes rhizome 10G, Fu a kind of reed mentioned in ancient books 30G, Chinese yam 30G, Radix Astragali 30G, lotus seeds 10G, stir-fried kidney beans 10G, fry heart of a lotus seed benevolence 10G, rhizoma atractylodis 10G, dried orange peel 10G, fleece-flower root 30G, fruit of glossy privet 10G, Eclipta prostrata 10G, barrenwort 30G, stir-baked MASSA FERMENTATA MEDICI-NALIS 30G, melanoidin malt 30G, rhizome of cyrtomium 15G, Semen Arecae (parched) 10G, pumpkin seeds 20G, dandelion 30G, purslane 30G, isatis root 20G and Radix Glycyrrhizae 6G by the following weight Chinese medicinal raw materials.
Embodiment 3
A kind ofly be used to improve weanling pig immunity and anti-parasitic-infectious Chinese herbal feed additive, form: Radix Codonopsis 90G, bighead atractylodes rhizome 30G, Fu a kind of reed mentioned in ancient books 90G, Chinese yam 90G, Radix Astragali 90G, lotus seeds 30G, stir-fried kidney beans 30G, fry heart of a lotus seed benevolence 30G, rhizoma atractylodis 30G, dried orange peel 30G, fleece-flower root 90G, fruit of glossy privet 30G, Eclipta prostrata 30G, barrenwort 90G, stir-baked MASSA FERMENTATA MEDICI-NALIS 90G, melanoidin malt 90G, rhizome of cyrtomium 45G, Semen Arecae (parched) 30G, pumpkin seeds 60G, dandelion 90G, purslane 90G, isatis root 60G and Radix Glycyrrhizae 18G by the following weight Chinese medicinal raw materials.
The medicament preparation of embodiment 2, embodiment 3 is with embodiment 1.
The present invention selects 60 of the interior weanling pigs of same child care house for use, is divided into 2 groups at random, and the I group is a control group; The basal diet of feeding, the II group is a Chinese drug-treated group, in basal diet, presses 2wt% and adds the Chinese herbal medicine medicament; One month is 1 course of treatment, carries out feeding experiment totally 2 courses of treatment.The present invention considers; Lymphocyte transformation rate is an important indicator estimating the body cell immunologic function; The level of the antibody behind the vaccine immunity then reflects the humoral immunity ability of body, so behind the Chinese herb feed additive of feeding, measured the weanling pig lymphocyte transformation rate; Selected hog cholera antibody and pig blue-ear disease antibody to detect simultaneously, with of the influence of checking Chinese herb feed additive to body's immunity as the index of reflection humoral immunity of organism.Table 1 is the influence of Chinese medicine additive to piglet lymphocyte transformation rate, hog cholera antibody level, pig blue-ear disease antibody horizontal.
Table 1
Visible by table 1, after 2 courses of treatment, Chinese drug-treated group significantly improves (P＜0.05) than the lymphocyte transformation rate of control group, explains that Chinese herb feed additive can significantly improve the lymphocyte transformation rate of weanling pig, can significantly improve cell immune function of human body; The hog cholera antibody qualification rate indifference (P＞0.05) of control group and two groups of pigs of Chinese drug-treated group before the test, the antibody horizontal basically identical; After the course of treatment (2 week of medication back), the qualified rate of Chinese drug-treated group has improved 4% than control group, and difference is remarkable (P＞0.05) not; After 2 courses of treatment (4 week of medication back), the qualified rate of Chinese drug-treated group has improved 19% than control group, significant difference (P＜0.05); Control group and two groups of pig blue-ear disease antibody of Chinese drug-treated group qualification rate indifference (P＞0.05) before the test, the antibody horizontal basically identical; After the course of treatment (2 week of medication back), the qualified rate of Chinese drug-treated group has improved 3% than control group, and difference is remarkable (P＞0.05) not; After 2 courses of treatment (4 week of medication back), the qualified rate of Chinese drug-treated group has improved 19% than control group, significant difference (P＜0.05).
Be the anti-parasitic-infectious effect of checking Chinese herb feed additive, intestine of young pigs parasite egg situation after medication of the present invention 1 course of treatment, after 2 courses of treatment.Table 2 is that Chinese herbal feed additive suppresses effect to the intestine of young pigs parasite egg.
Table 2
Can find out that from table 2 egg reduction rate of medication group is 46% to carry out variance analysis, significant difference with the control group result after 1 course of treatment; After 2 courses of treatment, the egg reduction rate of medication group be 57% with the control group result carry out variance analysis, significant difference.
The use result who experiment showed, Chinese herbal feed additive of the present invention has following characteristics:
1, strengthens weanling pig physique, improve immunity;
2, the raising piglet is anti-parasitic-infectious;
3, other communicable diseases such as prevention swine fever pig blue-ear disease;
4, strengthen nutrition, reduce the generation of dystrophic disease;
5, improve the quality of meat article.
Claims (4)
1. one kind is used to improve weanling pig immunity and anti-parasitic-infectious Chinese herbal feed additive, it is characterized in that being made up of the following weight Chinese medicinal raw materials: Radix Codonopsis 30-90G, bighead atractylodes rhizome 10-30G, Fu a kind of reed mentioned in ancient books 30-90G, Chinese yam 30-90G, Radix Astragali 30-90G, lotus seeds 10-30G, stir-fried kidney beans 10-30G, stir-fry heart of a lotus seed benevolence 10-30G, rhizoma atractylodis 10-30G, dried orange peel 10-30G, fleece-flower root 30-90G, fruit of glossy privet 10-30G, Eclipta prostrata 10-30G, barrenwort 30-90G, stir-baked MASSA FERMENTATA MEDICI-NALIS 30-90G, melanoidin malt 30-90G, rhizome of cyrtomium 15-45G, Semen Arecae (parched) 10-30G, pumpkin seeds 20-60G, dandelion 30-90G, purslane 30-90G, isatis root 20-60G and Radix Glycyrrhizae 6-18G.
2. Chinese herbal feed additive according to claim 1 is characterized in that being made up of the following weight Chinese medicinal raw materials: Radix Codonopsis 60G, bighead atractylodes rhizome 20G, Fu a kind of reed mentioned in ancient books 60G, Chinese yam 60G, Radix Astragali 60G, lotus seeds 20G, stir-fried kidney beans 20G, stir-fry heart of a lotus seed benevolence 20G, rhizoma atractylodis 20G, dried orange peel 20G, fleece-flower root 60G, fruit of glossy privet 20G, Eclipta prostrata 20G, barrenwort 60G, stir-baked MASSA FERMENTATA MEDICI-NALIS 60G, melanoidin malt 60G, rhizome of cyrtomium 20G, Semen Arecae (parched) 20G, pumpkin seeds 40G, dandelion 60G, purslane 60G, isatis root 40G and Radix Glycyrrhizae 12G.
3. the preparation method of a Chinese herbal feed additive according to claim 1, this method comprises the steps:
1. prepare burden: take by weighing Chinese medicine material by proportioning;
2. screening: remove the impurity in the Chinese medicine material;
3. drying and crushing: with the Chinese medicine material drying and crushing, cross 80 mesh sieves, mix, powder;
4. packing.
4. the method for using of a Chinese herbal feed additive according to claim 1 is characterized in that described Chinese herbal feed additive is made an addition in the feed by 2wt%.
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| CN1327783C (en) * | 2005-12-22 | 2007-07-25 | 中国科学院亚热带农业生态研究所 | Pigling immunopotentiated feed stuff and preparation method thereof |
| CN101731488B (en) * | 2010-01-07 | 2012-05-23 | 上海交通大学 | Chinese medicinal herb additive for preventing post-weaning diarrhea and pig feed thereof |
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| Title |
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| 王彬.中药复方饲料添加剂对断奶仔猪生长性能的影响.《饲料工业》.2010,第31卷(第5期),10－11. * |
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