CN103721227B - Traditional Chinese medicinal composition for preventing spleen and stomach deficiency type diarrhea for weaned piglets - Google Patents

Traditional Chinese medicinal composition for preventing spleen and stomach deficiency type diarrhea for weaned piglets Download PDF

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CN103721227B
CN103721227B CN201310707878.4A CN201310707878A CN103721227B CN 103721227 B CN103721227 B CN 103721227B CN 201310707878 A CN201310707878 A CN 201310707878A CN 103721227 B CN103721227 B CN 103721227B
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parts
spleen
deficiency type
chinese medicine
diarrhea
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CN103721227A (en
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牛志勇
陈小秋
赵素娟
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HEBEI KEXING PHARMACEUTICAL Co.,Ltd.
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HEBEI KEXING DRUG INDUSTRY Co Ltd
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Abstract

The invention discloses a traditional Chinese medicinal composition for preventing spleen and stomach deficiency type diarrhea for weaned piglets. The composition is prepared by adopting easily available traditional Chinese medicinal materials with low price, the relationship between dosage and compatibility of the medicine is prepared according to the pathogenesis of spleen and stomach deficiency type diarrhea caused by insufficient digestion support and enzyme system of weaned piglets, and the medicinal materials are compatible to play the effects of tonifying middle-jiao and qi, strengthening spleen and regulating qi, clearing damp and promoting diuresis, astringing and relieving diarrhea. Compared with an existing treatment medicine, the traditional Chinese medicinal composition has the characteristics of simple use, good curative effect, safe administration, no residue, low treatment cost, acceptance and the like, and is suitable for preventing spleen and stomach deficiency type diarrhea for weaned piglets.

Description

Prevent the Chinese medicine composition of weanling pig spleen and stomach deficiency type diarrhea
Technical field
The invention belongs to Chinese medicine composition field, it is related to a kind of Chinese medicine composition of preventing post-weaning diarrhea, specifically relates to And a kind of Chinese medicine composition of prevention weanling pig spleen and stomach deficiency type diarrhea.
Background technology
Grice diarrhoea refers to that the piglet at 1-3 monthly ages wants the mass-sending of symptom sick based on diarrhea, after especially weaning in 10-15 days The incidence of disease is very high, and very big loss is brought to pig industry.
Because the alimentary canal of weanling pig is not yet physically well developed, the physiological function imperfection such as immune system and body heat regulation, Due to changing food after weaned piglet, small intestines structure can change, the reduction of intestinal villus length, and crypts is deepened, or even crypts Depth is more than villus length, greatly reduces the function of enteron aisle, reduces intestinal absorption, and secretion increases.Into gastral food Indigestion, only enteropahtogenic microganism does not provide nutrition, and enteric cavity osmotic pressure can be caused to raise, and causes permeability abdomen Rush down.The survival rate and the speed of growth of piglet are had a strong impact on, or even causes lifelong production performance poor, bring certain to raiser Economic loss, and development to aquaculture brings tremendous influence.
Chinese invention patent CN101905014 discloses a kind of " treatment diarrhea of weaned piglets Traditional Chinese medicine compound composition ", adopts Mixed with distilled water with Chinese medicine material, decoction, filtering and impurity removing, merging filtrate, concentrated under reduced pressure, dry prepared, Chinese medicine material composition For:50~70 grams of Radix Codonopsis, 50~70 grams of the Radix Astragali, 50~70 grams of Radix Glycyrrhizae (processing), 30~50 grams of the bighead atractylodes rhizome, 20~40 grams of Fu a kind of reed mentioned in ancient books, rhizoma zingiberis 20~40 grams, 30~60 grams of Chinese yam, 30~60 grams of dried orange peel, 30~60 grams of hawthorn.It according to the cause of disease of diarrhea of weaned piglets, to manage Spleen and stomach, tonifying Qi, the principle prescription of eliminating dampness, the compound have conditioning intestine of young pigs micro-ecological environment, strengthen immunity Effect, to prevention and treatment diarrhea of weaned piglets there is significant effect;Adding proportion is low in daily ration, safe noresidue.But It is that the large usage quantity such as rare medicinal herbs Radix Codonopsis, Radix Astragali is relatively costly, and its preparation process is also in the raw material used by technique The operating procedure such as decocted, concentrated, being dried, it is cumbersome.
The content of the invention
The technical problem to be solved in the present invention, is to provide a kind of Chinese traditional medicine composition of prevention weanling pig spleen and stomach deficiency type diarrhea Thing, for weanling pig because digestive function and enzyme system imperfection trigger this sick cause of disease, formulates between flavour of a drug dosage and compatibility Relation, all medicines share in side, the effect of tonifying middle-Jiao and Qi, invigorating the spleen qi-regulating, clearing damp and promoting diuresis, astringing to arrest diarrhea are played altogether.With Current therapeutic Medication compares, and the present invention has easy to use, good effect, and drug safety, noresidue, low in treatment cost are easily accepted by waiting special Point.
In order to solve the above technical problems, the technical solution used in the present invention is:
It is a kind of prevent weanling pig spleen and stomach deficiency type diarrhea Chinese medicine composition, including following parts by weight raw material:
Radix Codonopsis 5-20 parts, root of large-flowered skullcap 5-10 parts, Radix Angelicae Sinensis 5-10 parts, dried orange peel 5-15 parts,
Bark of official magnolia 5-20 parts, umbellate pore furgus 5-10 parts, hawthorn 5-10 parts, rhizoma atractylodis 5-20 parts,
Radix Glycyrrhizae 1-5 parts, rhizoma zingiberis 5-15 parts, bighead atractylodes rhizome 5-20 parts, wheat bran 20-40 parts,
Tannic acid 1-3 parts.
Used as a kind of restriction of the invention, described hawthorn is stir-baked FRUCTUS CRATAEGI;Described Radix Glycyrrhizae is honey-fried licorice root;Described wheat bran To fry wheat bran.
Used as another restriction of the invention, the preparation method of said composition is to crush raw material, cross 40 mesh sieves, and mixing is equal It is even to obtain final product.
Specifically, Radix Codonopsis is main ingredient;The root of large-flowered skullcap, umbellate pore furgus are ministerial drug;Rhizoma zingiberis, the bighead atractylodes rhizome, rhizoma atractylodis, tannic acid be adjutant, Radix Angelicae Sinensis, Dried orange peel, the bark of official magnolia, hawthorn, Radix Glycyrrhizae, wheat bran are to make medicine.
Radix Codonopsis has tonifying middle-Jiao and Qi, effect of strengthening spleen and tonifying lung.For spleen and lung weakness, shortness of breath palpitations, anorexia and loose stool, void is breathed with cough Cough, Heat Diabetes etc..
The root of large-flowered skullcap has effect of heat-clearing and damp-drying drug, purging intense heat and detonicating etc..For cough with lung heat, stomach and intestine are damp and hot, the disease such as rush down dysentery.
Radix Angelicae Sinensis has replenishing and activating blood, menstruction regulating and pain relieving, the effect for relaxing bowel.For blood deficiency chlorosis, dizziness palpitaition, menstruation not Tune, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, ulcer sores.
Dried orange peel has regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm effect.For chest gastral cavity turgor, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
During the bark of official magnolia has promoting the circulation of qi wide, lower gas dissipate-swelling improves Digestive function, effect of eliminating dampness dissolving phlegm.Place food is cured mainly not disappear, Stagnation of QI due to dyspepsia etc..
Umbellate pore furgus has functions that clearing damp and promoting diuresis.Treatment difficult urination, oedema, diarrhea, stranguria with turbid discharge, under band.
Hawthorn is used to treat disperse accumulations, and the row stasis of blood is changed stagnant.
The wet tired transporting for causing of rhizoma atractylodis treatment taste is lacked of proper care, and poor appetite, vomiting is unhappy, abdominal distention diarrhea, arthralgia.
Radix Glycyrrhizae treats vital organs of the human body fever and chills perverse trend, and hard muscles and bones, muscle long, times strength, removing toxic substances, long term usage is made light of one's life by commiting suicide macrobiosis.It is raw to use Purging intense heat heat, it is ripe to go pharyngalgia with exterior cold is dissipated, except heat symptoms caused by an exopathgen, delay healthy tendency, yin-nourishing blood, tonifying spleen and stomach, moistening lung.
Rhizoma zingiberis treats coldness and pain in the epigastrium;Vomiting;Diarrhea, yang depletion is fainted inverse;Cold drink is breathed with cough;Numbness and ache of cold dampness.
The bighead atractylodes rhizome has strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, antiabortive effect.For spleen eating less, abdominal distention diarrhea, phlegm and retained fluid Feel dizzy and heart palpitations, oedema, spontaneous perspiration, fetal irritability.
Wheat bran has the effects such as moistening lung, skin care, cancer-resisting, strengthening the spleen and stomach, black hair strengthen the hair, cleaning stomach.
Tannic acid can precipitating proteins, can form insoluble compound with alkaloid, glucoside and heavy metal etc..
More than all medicines share, mutually collaboration, the effect of tonifying middle-Jiao and Qi, invigorating the spleen qi-regulating, clearing damp and promoting diuresis, astringing to arrest diarrhea are played altogether, Reach the effect treated both principal and secondary aspect of disease.
As a result of above-mentioned technical scheme, compared with prior art, acquired technological progress is the present invention:
The present invention is with Chinese veterinarian's theory as starting point, it is believed that it is deficiency of spleen-QI that weanling pig suffers from this sick main cause, Transporting is lost strong, and water is wet not to be transported etc. causes indigestion, diarrhoea, slow-growing etc., and the factor for causing diarrhoea is Spleen-Qi Deficiency, and spleen is not good for Fortune, stomach food stagnation, cold-damp affecting spleen, damp-heat retention in spleen;After wean, piglet do not adapt to feed from the breast milk being of high nutritive value easy to digest to Transformation based on heavy plant feed, takes food for 2-3 days after wean because a large amount of, causes digestion sluggish, indigested nutrient Some pathogenic microorganisms amount reproduction in the gastrointestinal tract is caused, causes grice diarrhoea;Because food changes after wean, small intestines structure Change, reduce intestinal absorption, secretion increases, and causes diarrhoea.
In medicament composing prescription provided by the present invention, Radix Codonopsis tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung is main ingredient.Fu a kind of reed mentioned in ancient books, umbellate pore furgus excreting dampness profit Water, by trembling with fear, the moon is held back in root of herbaceous peony smooth liver and relieve pain, blood-nourishing to rhizoma zingiberis middle benefit gas;Rhizoma atractylodis are drying damp and strengthening spleen, dried orange peel regulating qi-flowing for strengthening spleen, the bark of official magnolia place food do not disappear, Stagnation of QI due to dyspepsia, Radix Glycyrrhizae is invigorated the spleen and benefited qi, and above-mentioned all medicines are altogether adjuvant.Plant extracts tannic acid has protein precipitation, and convergence stops Rush down, sterilized effect.The present invention, because digestive function and enzyme system imperfection trigger this sick cause of disease, formulates medicine for weanling pig Relation between taste dosage and compatibility, all medicines share in side, plays tonifying middle-Jiao and Qi altogether, invigorating the spleen qi-regulating, clearing damp and promoting diuresis, astringing to arrest diarrhea it Effect, reaches the effect treated both principal and secondary aspect of disease..Compared with Current therapeutic medication, easy to use, good effect of the invention, drug safety, Noresidue, low in treatment cost is easily accepted by.Prevention weanling pig spleen and stomach deficiency type diarrhea obtained by the present invention after use, energy Reduce incidence of disease 91.9%-92.8%.
The present invention is applied to prevention weanling pig spleen and stomach deficiency type diarrhea.
The present invention is described in further detail below in conjunction with specific embodiment.
Specific embodiment
A kind of Chinese medicine composition of prevention weanling pig spleen and stomach deficiency type diarrhea of embodiment 1
It is a kind of prevent weanling pig spleen and stomach deficiency type diarrhea Chinese medicine composition, including following parts by weight raw material:
Radix Codonopsis 10g, root of large-flowered skullcap 5g, Radix Angelicae Sinensis 7g, dried orange peel 12g, bark of official magnolia 13g,
Umbellate pore furgus 10g, stir-baked FRUCTUS CRATAEGI 6g, rhizoma atractylodis 8g, honey-fried licorice root 3g, rhizoma zingiberis 10g,
Bighead atractylodes rhizome 11g, fries wheat bran 30g, tannic acid 1g.
The preparation method of said composition is raw material to be combined according to parts by weight, is crushed, crossing 40 mesh sieves, is well mixed i.e. .
The reduction incidence of disease of the Chinese medicine composition of prevention weanling pig spleen and stomach deficiency type diarrhea is obtained in the above method 92.1%。
Embodiment 2-6 prevents the Chinese medicine composition of weanling pig spleen and stomach deficiency type diarrhea
Embodiment 2-6 is respectively a kind of Chinese medicine composition of prevention weanling pig spleen and stomach deficiency type diarrhea, and preparation method is identical, The parts by weight that the difference is that only raw material from embodiment 1 are different, shown in table specific as follows:
Hawthorn therein is alternatively stir-baked FRUCTUS CRATAEGI;Radix Glycyrrhizae is alternatively honey-fried licorice root;Wheat bran is alternatively stir-fry wheat bran.
The embodiment 1 of embodiment 7 carries out effect and compares with blank group
Embodiment 1 and blank group are compared, specific experiment condition and result are as follows:
1 blank group is without medicine group;Experimental group is the group that with the addition of obtained Chinese medicine composition in embodiment 1;
2 experiment feeds:Feed factory autogamy pig feed
The new U.S.A of 3 experimental subjects is Landrace
4 experiment places:Nan Gonghuarun livestock culturings company
5 experiment packets
Blank group and experimental group are randomly divided into 2 groups, daily ration of the feeding containing the Chinese medicine composition 0.1% obtained by embodiment 1 with Blank group carries out clinical trial by normal feeding, it is determined that Chinese medicine of the present invention is increased weight in raising, improves food conversion ratio, strengthens body The effect of the aspects such as immunity.
6 raising experiments
Swine rearing participate in the experiment in same pig house, daily management is identical, special messenger be responsible for, feed daily 3 times, free choice feeding with drink Water.Weigh and number by head when prerun starts, experiment starts and weighed by head again at the end of testing, and records feed consumption rate day by day, Finally calculate daily gain and feed conversion rate.
Result is as follows:
Wherein, feedstuff-meat ratio refers to consumption feed total amount(kg)/ weightening total amount(kg);Diarrhea rate refers to(Suffer from diarrhoea total head time/real Test total head number)×100%.
Since upper table experimental data, it is apparent that age in days carried out prophylactic treatment for 30 days in piglet for, add Chinese medicine group of the present invention increases average daily weight 15.46% compared with blank group, reduce Scours index and reduce feedstuff-meat ratio this several respect also has Apparent effect, and naked eyes above, performance be Application Example 1 pig skin it is ruddy, hair color is glossy, excrement There is no the smell that spy smells, fanning economics are brought to aquaculture.
The embodiment 1 of embodiment 8 compares with the effect of antibiotic
At present, the medicine for the treatment of piglet spleen and stomach deficiency type diarrhea is mainly Antibiotics medicine, especially florfenicol powder, phosphorus Sour tylosin pre-mixing agent etc., but with the enhancing of people's living standard and health perception, the use of antibiotic is reduced, so that People are reduced to the intake of antibiotic, is received by increasing consumer, therefore should tried one's best when Animal diseases are treated The use of antibiotics is avoided, a kind of noresidue that antibiotic therapy can be replaced to prevent piglet spleen and stomach deficiency type diarrhea is selected Chinese medicine composition be necessary.
Chinese medicine composition obtained by conventional florfenicol powder, Tylosin phosphate pre-mixing agent and embodiment 1 is carried out Compare, specific experiment condition and result are as follows:
11 group of control is florfenicol powder group;2 groups are compareed for Tylosin phosphate pre-mixing agent group;Experimental group is that with the addition of Obtained Chinese medicine composition in embodiment 1;
2 experiment feeds:Feed factory autogamy pig feed
The new U.S.A of 3 experimental subjects is Landrace
4 experiment places:Nan Gonghuarun livestock culturings company
5 experiment packets
Experimental group is randomly divided into 2 groups, daily ration of the feeding containing the Chinese medicine composition 0.1% obtained by embodiment 1.The fluorine of control group 1 Benzene Buddhist nun examines the daily ration of the powder usage amount body weight mixed feedings of the 20mg/kg in terms of Florfenicol, and the Tylosin phosphate pre-mixing agent of control group 2 is with Thailand Happy rhzomorph meter addition 68.4g mixed feedings per 100kg feeds, carry out clinical trial, it is determined that improve increase weight, improve food conversion ratio, The effect of the aspects such as enhancing immunity of organisms.
6 raising experiments
By swine rearing in same pig house, daily management is identical, special messenger be responsible for, feed daily 3 times, free choice feeding with drink Water.Weigh and number by head when prerun starts, experiment starts and weighed by head again at the end of testing, and records feed consumption rate day by day, Finally calculate daily gain and feed conversion rate.
Result is as follows:
As seen from the above table, for starting age in days for 30 days carry out prophylactic treatment in piglet, in feed consumption index, control 1,2 Group is not notable relative to experimental group difference(P>0.05), showing the medicine of addition does not influence the palatability of feed.In weightening index On, experimental group improves 13.03%, 12.11%, significant difference for 1,2 groups than control(P<0.05).In feedstuff-meat ratio index, experiment Group reduces 3.22%, 3.06% for 1,2 groups respectively than control, and difference is not notable(P>0.05), show prepared by addition embodiment 1 Chinese medicine composition can improve efficiency of feed utilization.In diarrhoea index, experimental group compares with compareing 1,2 groups, and difference is not notable(P> 0.05), show that the prevention of diarrhea in piglets of embodiment 1 is substantially suitable with effects of antibiotics, with embodiment 1 antibiotic prophylaxis can be replaced young Diarrhea of pigs.And the Chinese medicine composition obtained by embodiment 1 is compared with antibiotic control group, in animal body noresidue.
The embodiment 1 of embodiment 9 compares with CN101905014 effects
The preparation and preparation of control group, obtained Chinese medicine compound prescription combination are carried out according to prescription disclosed in CN101905014 Thing carries out compliance test result and compares with embodiment 1, and specific experiment condition and result are as follows:
1 control group is the Chinese medicine compound prescription combination of preparation and preparation that prescription disclosed in CN101905014 carries out control group Thing;Experimental group is that with the addition of obtained Chinese medicine composition in embodiment 1;
2 experiment feeds:Feed factory autogamy pig feed
The new U.S.A of 3 experimental subjects is Landrace
4 experiment places:Nan Gonghuarun livestock culturings company
5 experiment packets
Experimental group is randomly divided into 2 groups with control group, respectively day of the feeding containing the Chinese medicine composition 0.1% obtained by embodiment 1 Traditional Chinese medicine compound composition obtained by grain and control group carries out clinical trial, it is determined that increasing weight, improving food conversion ratio, increasing improving The effect of the aspects such as strong immunity of organisms.
6 raising experiments
Experimental group is randomly divided into 2 groups with control group, raises in same pig house, and daily management is identical, and special messenger is responsible for, daily Feed 3 times, free choice feeding with drinking-water.Weigh and number by head when prerun starts, experiment starts and claims by head again at the end of testing Weight, and feed consumption rate is recorded day by day, finally calculate daily gain and feed conversion rate.
Result is as shown in the table:
As seen from the above table, for starting age in days for 30 days carry out prophylactic treatment in piglet, can be with bright from upper table experimental data It is aobvious find out 1 group of Chinese medicine composition of embodiment to increasing daily gain, reduce diarrhea of pigs and reduce feedstuff-meat ratio this several respect and have clearly Effect, and pig in 1 group of Chinese medicine composition of Application Example there occurs great changes in appearance, be mainly shown as pig Skin is ruddy, hair color is glossy, excrement does not have the smell that spy smells, 1 group of Chinese medicine composition of embodiment be aquaculture realize efficiently, peace Entirely, the health care good medicine of high yield.
The embodiment 1 of embodiment 10 compares with the effect of the commercially available Chinese medicine with prevention of diarrhea in piglets
The commercially available Chinese medicine with prevention of diarrhea in piglets and the Chinese medicine composition obtained by embodiment 1 are carried out into effect to compare, Experiment condition and result are as follows:
1 control group is cure dysentery medicine group, and the lot number for being certain veterinary drug manufacturer production is 12050701 cure dysentery medicine Chinese medicine;Experiment Group is the Chinese medicine composition of embodiment 1.
2 experiment feeds:Feed factory autogamy pig feed
3 experimental subjects:Landrace, Large White and binary pig
4 usage and dosages:All it is by 0.1% spice application
5 experiment packets
2 groups are randomly divided into after immunity inoculation, expelling parasite by weanling pig, male and female half and half, uniform in size, body weight is well-balanced, it is real It is the Chinese medicine composition by 0.1% addition embodiment 1 to test group 1, and experimental group 2 is by the 0.1% commercially available Chinese medicine of addition, every group 150.
6 feedings and managements
Experimental group and control group are randomly divided into 2 groups, in same pig house, same poultry raiser's management, feeding are right before experiment Pigsty is thoroughly cleaned and sterilized, and checks pig house, apparatus, isolation house, the implementation of conditions of fecaluria treatment, and experiment piglet is certainly By drinking water, daily 8:00、12:00、16:00 feeding is once, early daily to feed preceding observation swinery health status.
Result is as shown in the table:
Since upper table experimental data, it is apparent that age in days carried out prophylactic treatment for 30 days in piglet for, add Chinese medicine of the present invention to increasing daily gain, reduce diarrhea of pigs and reduce feedstuff-meat ratio this several respect play the role of it is apparent, and should Great changes are there occurs in appearance with the pig of patent Chinese medicine of the present invention, are mainly shown as that pig skin is ruddy, hair color has light Pool, excrement do not have the smell that spy smells, with good effect.
The above, is only presently preferred embodiments of the present invention, is not the limitation for making other forms to the present invention, is appointed What those skilled in the art, as enlightenment, is changed or is modified as equivalent variations possibly also with above-mentioned technology contents Equivalent embodiments.But it is every without departing from technical solution of the present invention content, according to technical spirit of the invention to above example Done simple modification, equivalent variations and remodeling, still fall within the protection domain of the claims in the present invention.

Claims (3)

1. it is a kind of prevent weanling pig spleen and stomach deficiency type diarrhea Chinese medicine composition, it is characterised in that by the raw material of following parts by weight Composition:
Radix Codonopsis 5-20 parts, root of large-flowered skullcap 5-10 parts, Radix Angelicae Sinensis 5-10 parts, dried orange peel 5-15 parts,
Bark of official magnolia 5-20 parts, umbellate pore furgus 5-10 parts, hawthorn 5-10 parts, rhizoma atractylodis 5-20 parts,
Radix Glycyrrhizae 1-5 parts, rhizoma zingiberis 5-15 parts, bighead atractylodes rhizome 5-20 parts, wheat bran 20-40 parts,
Tannic acid 1-3 parts.
2. it is according to claim 1 prevention weanling pig spleen and stomach deficiency type diarrhea Chinese medicine composition, it is characterised in that:It is described Hawthorn be stir-baked FRUCTUS CRATAEGI;Described Radix Glycyrrhizae is honey-fried licorice root;Described wheat bran is stir-fry wheat bran.
3. it is according to claim 1 and 2 prevention weanling pig spleen and stomach deficiency type diarrhea Chinese medicine composition, it is characterised in that: The preparation method of said composition is to crush raw material, cross 40 mesh sieves, well mixed to obtain final product.
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Denomination of invention: Traditional Chinese medicine combination for preventing diarrhea caused by spleen and stomach deficiency in weaned piglets

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Denomination of invention: Traditional Chinese medicine combination for preventing diarrhea caused by spleen and stomach deficiency in weaned piglets

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