CN103250878B - Traditional Chinese medicine feed for treating swine plague, as well as preparation method and appliction thereof - Google Patents
Traditional Chinese medicine feed for treating swine plague, as well as preparation method and appliction thereof Download PDFInfo
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Abstract
The invention provides traditional Chinese medicine feed for treating swine plague. The traditional Chinese medicine feed for treating swine plague comprises white atractylodes rhizome, root of kudzu vine, Chinese angelica, radix bupleuri, lithospermum, safflower, honeysuckle, scutellaria baicalensis, pinellia ternate, brucea javanica, sculellaria barbata, rhizoma bletillae, codonopsis pilosula, fructus forsythiae, houttuynia cordata, milkvetch, schisandra chinensis, radix scrophulariae, gastrodia elata, glossy privet fruit, polygonum cuspidatum and liquorice. The Chinese medicine composition is reasonable in composition, can achieve synergistic interaction, has a stronger antiviral effect and has the advantages of obvious curative effect, treatment on both symptoms and root causes, strengthening of the body resistance for eliminating evil, high curative ratio, no toxic or side effect, difficult recurrence, no phytotoxicity, no drug resistance, low cost and improvement on immunity of an organism.
Description
Technical field
The present invention relates to field of feed, relate in particular to a kind of Chinese medicine fodder that is used for the treatment of swine plague.
Background technology
Swine plague is by the caused a kind of acute infectious disease of multiple lethal Pasteurella (swine plague), is commonly called as " lockjawed laryngitis ", " swollen neck pest ".Acute or chronic process, the acute septicemia that is changes, bottleneck throat swelling, highly expiratory dyspnea.Swine plague is a kind of acute infectious disease of live pig, acute taking septicemia, inflammatory hemorrhage and pleuropneumonia as feature, therefore have another name called schweineseuche (be called for short and to lose).This disease distributes very wide, all there is generation all over the world, and usually with concurrent or this disease of scabies secondary infection of some breathing problems (as contagious infection pleuropneumonia etc.), although significantly not seasonal, to cold and heat succeed each other, easily to infect in climate variability season.Generally be sporadic or endemicity, because the part pig upper respiratory tract carries disease germs, so long-distance transport, feeding and management is improper, sanitary condition is poor, environmental catastrophe and utilize the reasons such as restaurant's leftover bits and pieces be morbidity key factor.
Through laboratory examination results, pasteurella multocida belongs to Pasteurella section Pasteurella, is Gram-negative, the blunt circle in two ends, the coccobacillus of central dimpling or brevibacterium.Do not form brood cell, atrichia, can not move, and the virulent strain separating has pod membrane, and Chang Dan exists.With pathological material of disease tissue or body fluid smear, during with Rui Shi, Ji's nurse Sa or methylene blue, thalline is oval more, and the two poles of the earth color depth, like two coccuses arranged side by side.This bacterium is aerobic and facultative anaerobe.The bacterium colony of growing on serum agar, is bluish-green colour band golden light, and there is narrow reddish yellow light belt at edge, is called Fg type, and bacterium colony is Exocarpium Citri Rubrum colour band golden light, and edge or have milky white colour band is called F0 type; The bacterium colony with fluorescence is not Nf type.This bacterium is all not strong to direct sunlight, resistance dry, hot and conventional disinfectant, but in corrupt corpse, can survive 1～3 month.。This bacterium is present in the each tissue of disease pig whole body, body fluid, secretion and excreta, only have the chronic case of minority to exist only in the small lesion of lungs, health pig also can be with this bacterium sometimes, according to report, account for 31% health pig and be separated to Pasteurella in nasal cavity, larynx, tonsillotome, under some stress factor effect, when the resistance of pig weakens, also can cause autogenous infection.
Pasteurella multocida can infect many animals, and pig is wherein a kind of, and the pig at various ages all can infection morbidity, and the incidence of disease of piggy and middle pig is higher.Sick pig and the health pig that carries disease germs is the infection sources, and pathogen is mainly present in lungs focus and the each organ of disease pig, exists in the respiratory tract and intestinal tube of health pig, excretes with secretion and excreta, infects through the skin of respiratory tract, alimentary canal and damage.The pig that carries disease germs catches cold, catches a cold, overwork, feeding and management are improper, when resistance is reduced, autologous endogenous can occur and infect.Swine plague is normal for distributing, it is generally acknowledged that this bacterium is a kind of conditionity pathogen, when pig is in bad external environment, as cold, sultry, weather drastic change, humidity, crowded, improper ventilation, nutritional deficiency, fatigue, long-distance transport etc., cause the resistance of pig to decline, at this moment pathogen breeds and causes morbidity in a large number.Sick pig, through the discharge of bacteria such as secretion, excreta, pollutes drinking-water, feed, apparatus and external environment in addition, is transmitted to health pig through alimentary canal, is also the important routes of infection.Also can by cough, sneeze discharge cause of disease, by the spittle through respiratory tract infection.In addition, hematophagus bites skin and mucous membrane wound all can infect.This disease is general without significantly seasonal, but colding and heat succeed each other, climate variability, high temperature season be multiple, is generally sporadic or endemicity.
Be divided into the most acute, acute and chronic type according to course of disease length and clinical manifestation.Acute: there is not any symptom, sudden onset, dead rapidly.The course of disease slightly elder shows hyperthermia to 41～42 DEG C, and appetite is useless absolutely, expiratory dyspnea, heartbeat rapidly, visual mucous membrane cyanosis, there is purplish-red macula in skin.Bottleneck throat and neck heating, red and swollen, hard, severe patient is extended down to the basal part of the ear, front.Sick pig breathes and is the devil, and is often sitting position of dog gesture, extends neck, sometimes can send the sound of stridulating, and mouth and nose flow out white foam, sometimes with color.Once there is serious expiratory dyspnea, the state of an illness often worsens rapidly, very fast dead.Death rate Chang Gaoda 100%, spontaneous remission person is rare.Acute: this type is the most common.Hyperthermia to 40～41 DEG C, the initial stage is spastic dry cough, expiratory dyspnea, mouth and nose flow out foam, be sometimes mixed with blood, after become wet cough.With disease, breathe more difficultly, often make sitting position of dog gesture, chest palpation has pain.Lassitude, poor appetite or absolutely useless, there is erythema in skin, later stage languishment does not rise sleepingly, how because of death by suffocation.The course of disease 5～8 days, the dead does not transfer to chronic.Chronic type: main manifestations is pneumonia and chronic gastroenteritis., there is continuation cough in time and has difficulty in breathing, and has a little hydrodynamic or purulence nose liquid.Arthroncus, often has diarrhoea, poor appetite, and malnutrition, has scab sample eczema, and growth stops, skeletonize, the course of disease is more than 2 weeks, and most generations are dead.
In modernization cultivation, feed addictive is almost applied to (comprising trophism and non-nutritive additive) overall process of growth of animals or poultry.And most feed addictives all contain the compositions such as chemical drug, antibiotic and hormone, the lasting application of these compositions will cause increasing of canceration, sudden change, aberration rate.Modern medicine and pharmacology achievement in research shows, much Chinese medicine contains abundant polysaccharide, alkaloids, organic acid, glucoside, volatile oil and resinae etc.The Chinese medicine preparation made from these materials is for animal, have antiviral, antibacterium, anti-stress effect.Chinese medicine is with entirety adjustment, and Yin Yang balancing is feature, is comparatively ideal immunomodulator.Can improve the histiocytic activity of immune system, increase the growth of immune cell and synthesizing of antibody, regulate the immunologic function of body, improve the premunition of body, especially resist virus infections and pathogenic ability.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of novel Chinese medicine fodder of swine plague and preparation method thereof that is used for the treatment of, and treatment has evident in efficacyly to swine plague to adopt this Chinese medicine fodder, and cure rate is high, is difficult for the advantages such as recurrence.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine fodder that is used for the treatment of swine plague, it comprises feed vector and Chinese medicine composition additive, it is characterized in that Chinese medicine composition additive comprises: the bighead atractylodes rhizome, the root of kudzu vine, Radix Angelicae Sinensis, radix bupleuri, Asian puccoon, safflower, honeysuckle, the root of large-flowered skullcap, the tuber of pinellia, Java brucea, Sculellaria barbata, bletilla, Radix Codonopsis, the capsule of weeping forsythia, cordate houttuynia, the Radix Astragali:, the fruit of Chinese magnoliavine, radix scrophulariae, rhizoma Gastrodiae, the fruit of glossy privet, giant knotweed, Radix Glycyrrhizae.
Wherein, the ratio of weight and number of the each component in described Chinese medicine composition additive is, bighead atractylodes rhizome 20-40 weight portion, root of kudzu vine 20-35 weight portion, Radix Angelicae Sinensis 30-40 weight portion, radix bupleuri 10-20 weight portion, Asian puccoon 5-15 weight portion, safflower 20-30 weight portion, honeysuckle 20-30 weight portion, root of large-flowered skullcap 10-25 weight portion, tuber of pinellia 10-25 weight portion, Java brucea 10-20 weight portion, Sculellaria barbata 10-15 weight portion, bletilla 10-20 weight portion, Radix Codonopsis 20-30 weight portion, capsule of weeping forsythia 10-15 weight portion, cordate houttuynia 20-25 weight portion, Radix Astragali 20-40 weight portion, fruit of Chinese magnoliavine 10-15 weight portion, radix scrophulariae 10-15 weight portion, rhizoma Gastrodiae 10-20 weight portion, fruit of glossy privet 10-15 weight portion, giant knotweed 10-15 weight portion, Radix Glycyrrhizae 10-40 weight portion.
Wherein, described Chinese medicine composition additive can will be above-mentioned Chinese medicine composition directly mix with feed after pulverizing, mix with feed vector again after also can making particular dosage form, formulation can be the regular dosage forms such as decoction, pulvis, granule, injection.
Feed vector can be one or more mixing in corn, dregs of beans, wheat bran, paddy.
For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned feed, it comprises: the first step, each component in described Chinese medicine composition additive is mixed in proportion, obtain mixture, add the water with respect to 2 ~ 4 times of mixture qualities, decoct and process 1～3 hour, decoction liquor is filtered, concentration, obtain the lotion of removing moisture, by the ethanol that to add with respect to the determining alcohol of 3～5 times of first step mixture qualities in the lotion of acquisition be 65% ~ 75%, stir 20 minutes ~ 40 minutes, at 0～4 DEG C, refrigerate 1 ~ 2 hour, filter, decompression recycling ethanol, obtain and get dry extract, dry, be ground into 20 order ~ 200 object powder, obtain Chinese medicine composition additive, second step, puts into pulverizer by feed vector and is ground into 20 ~ 30 object powder, the 3rd step, the feed vector powder that the Chinese medicine composition additive that the first step is obtained, second step obtain is put into mixer and is stirred, and pours into subsequently in spraying machine, in spraying machine, water temperature is modulated at 60 ~ 70 DEG C, open sprayer, stir 1 ~ 2 minute, continue to be warming up to 90 DEG C and complete expanded, the 4th step, adds the water with respect to 0.1 ~ 0.3 times of its quality by the product after expanded, puts into granulator and granulates, and granulator electric current is 175A, the 5th step, dry after granulating, baking temperature is 105 DEG C, drying time 15 ~ 25min, then put into blower fan cooling, cool time, 20 ~ 40min, obtained described feed.
For solving the problems of the technologies described above, the present invention also provides the preparation method of the above-mentioned Chinese medicine composition additive of different dosage form:
The preparation method of powder: after taking raw material, bulk drug and pulverizing, sieve, fully mix and make powder.
The preparation method of granule: the first step, each component in described Chinese medicine composition additive is mixed in proportion, obtain mixture, add the water with respect to 2 ~ 4 times of mixture qualities, decoct and process 1～3 hour, decoction liquor is filtered, concentration, obtain the lotion of removing moisture, by the ethanol that to add with respect to the determining alcohol of 3～5 times of first step mixture qualities in the lotion of acquisition be 65% ~ 75%, stir 20 minutes ~ 40 minutes, at 0～4 DEG C, refrigerate 1 ~ 2 hour, filter, decompression recycling ethanol, obtain and get dry extract, dry, be ground into 20 order ~ 200 object powder, obtain Chinese medicine composition additive, second step, puts into pulverizer by feed vector and is ground into 20 ~ 30 object powder.
The preparation method of pulvis: each component in described Chinese medicine composition additive is mixed in proportion, obtain mixture, after crude drug mixture is pulverized, first with ethanol, medicinal material was soaked after 2 hours, alcohol reflux extracts 2 times, and each 2 hours, merging filtrate was also condensed into thick paste shape; Filter residue again water extracts 2 times, extracts for the first time 2.5 hours, extracts for the second time 1.5 hours, filters, and merging filtrate is also condensed into thick paste shape; Merge medicinal extract, finally add appropriate amount of starch and dextrin (or other auxiliary material), mix, dry, pulverize, be prepared into pulvis.
Decoction preparation method: each component in described Chinese medicine composition additive is mixed in proportion, obtain mixture, after crude drug mixture is pulverized, water soaks medicinal material after 1-2 hour, then decoct to boiling with high heat, then use slow fire boiling 30 minutes, filter, filter residue adds water with slow fire boiling twice, each 1 hour.Merging filtrate, adding ethanol to ethanol content in filtrate after filtrate is concentrated is 70%, filter, filtrate recycling ethanol, concentrated, filtration, embedding, sterilizing, be prepared into oral liquid.
Injection preparation method: each component in described Chinese medicine composition additive is mixed in proportion, obtain mixture, after crude drug mixture is pulverized, water soaks medicinal material after 1-2 hour, then decoct to boiling with fiery, then with little fire decoction 30 minutes, filter, filter residue decocts twice, each 1 hour with little fire.Merging filtrate, adding ethanol to ethanol content in filtrate after filtrate is concentrated is 70%, filter, filtrate recycling ethanol, concentrated, refrigeration, filtration, smart filter, embedding, sterilizing, be prepared into injection.
For solving the problems of the technologies described above, the present invention also provides a kind of Chinese medicine composition that is used for the treatment of animal swine plague, comprising: the bighead atractylodes rhizome, the root of kudzu vine, Radix Angelicae Sinensis, radix bupleuri, Asian puccoon, safflower, honeysuckle, the root of large-flowered skullcap, the tuber of pinellia, Java brucea, Sculellaria barbata, bletilla, Radix Codonopsis, the capsule of weeping forsythia, cordate houttuynia, the Radix Astragali, the fruit of Chinese magnoliavine, radix scrophulariae, rhizoma Gastrodiae, the fruit of glossy privet, giant knotweed, Radix Glycyrrhizae.
For solving the problems of the technologies described above, the present invention also provides a kind of Chinese medicine composition that is used for the treatment of animal swine plague, described Chinese medicine composition is prepared from by the following method: each component in described Chinese medicine composition additive is mixed in proportion, obtain mixture, add the water with respect to 2 ~ 4 times of mixture qualities, decoct and process 1～3 hour, decoction liquor is filtered, concentration, obtain the lotion of removing moisture, by the ethanol that to add with respect to the determining alcohol of 3～5 times of first step mixture qualities in the lotion of acquisition be 65% ~ 75%, stir 20 minutes ~ 40 minutes, at 0～4 DEG C, refrigerate 1 ~ 2 hour, filter, decompression recycling ethanol, obtain and get dry extract, dry, be ground into 20 order ~ 200 object powder.
For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned Chinese medicine composition, and it comprises:
Each component in described Chinese medicine composition additive is mixed in proportion, obtain mixture, add the water with respect to 2 ~ 4 times of mixture qualities, decoct and process 1～3 hour, decoction liquor is filtered, concentration, obtain the lotion of removing moisture, by the ethanol that to add with respect to the determining alcohol of 3～5 times of first step mixture qualities in the lotion of acquisition be 65% ~ 75%, stir 20 minutes ~ 40 minutes, at 0～4 DEG C, refrigerate 1 ~ 2 hour, filter, decompression recycling ethanol, obtains and gets dry extract, and dries, is ground into 20 order ~ 200 object powder.
For solving the problems of the technologies described above, the present invention also provides above-mentioned Chinese medicine fodder and the application of Chinese medicine composition in the medicine for the preparation for the treatment of swine plague.
Beneficial effect of the present invention:
With respect to the medicine that is used for the treatment of swine plague of the prior art, adopt this Chinese medicine composition to have swine plague treatment evident in efficacy, cure rate is high, and the advantage such as have no side effect.
Detailed description of the invention
The invention provides a kind of like this Chinese medicine fodder that is used for the treatment of swine plague, it comprises: the bighead atractylodes rhizome, the root of kudzu vine, Radix Angelicae Sinensis, radix bupleuri, Asian puccoon, safflower, honeysuckle, the root of large-flowered skullcap, the tuber of pinellia, Java brucea, Sculellaria barbata, bletilla, Radix Codonopsis, the capsule of weeping forsythia, cordate houttuynia, the Radix Astragali:, the fruit of Chinese magnoliavine, radix scrophulariae, rhizoma Gastrodiae, the fruit of glossy privet, giant knotweed, Radix Glycyrrhizae.
Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability." property of medicine opinion " carries it: monarch, taste is sweet, pungent, nontoxic.The large wandering arthritis of energy master, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, removes fever and chills, under stopping, lets out.Interarea light is happy, preserves youthful looks, and de-black.The swelling of harnessing the river is full, tells to vomit contraryly, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.Pseudo-ginseng: sweet, the micro-hardship of taste, warm in nature, enter liver, stomach warp, there is hemostasia and dissipation blood stasis, the effect of swelling and pain relieving, be mainly used in hemoptysis, uterine bleeding etc. various go out blood trouble, hemangiectasis, reduce blood pressure, improve microcirculation, increase CBF, prevention and treatment heart and brain tissues ischemic, air hunger; Promote protein, ribonucleic acid (RNA), DNA (DNA) to synthesize, improve the health; Promote blood cell metabolism, balance adjustment blood cell; Bidirectional modulation nervous centralis, improves mentally, strengthens learning and memory ability; Hemostasis, promoting blood circulation and removing blood stasis; Protect the liver, anti-inflammatory.
The root of kudzu vine: taste is sweet, pungent, cool in nature, enters spleen, stomach warp, has inspiration stomach Qi, clearing heat and promoting fluid, and expelling pathogenic factors from muscles and skin is delivered, raw positive, oozes the effect of rash, is mainly used in fever caused by exogenous pathogens, headache, stiff nape and back, pyreticosis is thirsty, quenches one's thirst; Splenasthenic diarrhea, the cards such as lucid yang failing to raise, the root of kudzu vine is gently let out wet middle intrinsic heat clearly thoroughly.
Radix Angelicae Sinensis: its taste is sweet and weigh, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting circulation of blood, and bowl spares has, in row, has benefit, the really gas medicine in blood, the also panacea in blood.Approximately mending to mend of assistant, thus can support nutrition blood, tonifying Qi production of sperm, five viscera settling, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant logical to attack, therefore the pain defaecation of dispelling, relieving rigidity of muscles and joints, controls contraction, paralysis, the card such as dry, puckery.Seek void and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and table is not held back person, and assistant, with rheum officinale and so on, can be shown again admittedly.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Radix bupleuri: meridian distribution of property and flavor: cold nature, bitter, pungent, return Liver Channel, gallbladder channel, table expels the heat-evil thoroughly, soothing liver-qi stagnation, elevate a turnable ladder yang-energy, is mainly used in cold, fever, fevers and chills alternate, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, uterus comes off, irregular menstruation.
Asian puccoon: nature and flavor: cold in nature, taste is sweet, salty, the thoughts of returning home, Liver Channel, be mainly used in that blood-head poison is contained, macula purple is black, measles without adequate eruption, sore, eczema, scald etc.
Safflower is warm in nature, and taste is pungent.Cure mainly the latus rectum of invigorating blood circulation, blood stasis removing analgesic.For through closing, dysmenorrhoea, lochia, abdominal mass lump in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": safflower, the medicine of broken blood, promoting circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, navel eilema; Or drop slurry is difficult raw; Or afterbirth do not fall, in the dead abdomen of son, be all just before giving birth all cards, non-safflower can not be controlled.If keeping silent, postpartum anemic fainting, mouth refer to hold in the hand; Or heresy enters blood chamber, delirious speech is gone mad; Or blood is vexed interior swollen, sudden syncope is as extremely, be all postpartum all cards, non-safflower can not be determined.All as hand over and do through closing obstructed and fever and chills, or expired stomachache and purple black dripping, or injury from falling down and the qi and blood stasis of blood is long-pending, or sore sufferings and swollenly burst uneasyly, be cards of qi and blood discord all, non-safflower can not be adjusted." medicine justice ": safflower, kind tonneau passages through which vital energy circulates, is gas medicine in blood, can rush down and can mend, and respectively has wonderful justice.If multiplex three, four money, too pungent temperature, wanders away blood., close Chinese cassia tree and stimulate the menstrual flow and close by hemostasis with bush, assistant is returned, Chinese herbaceous peony is controlled all over or chest abdomen pricking caused by the stagnation of QI and blood, and this its row is led and invigorates blood circulation also.
Honeysuckle: taste is sweet, cold in nature, enters the heart, lung, stomach, large intestine channel, has clearing heat and detoxicating effect, double can removing heat from the blood and relieve diarrhea.Be mainly used in affection of exogenous wind-heat, the hot poison of warm heat disease is contained, or warm disease is from the beginning of heat evil still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; The malicious diarrhea of heat, the lower blood of stool; Heat temperature card; The sore carbuncle that hot poison gathers is from the beginning of, inflammation heat person of swelling and ache etc., honeysuckle has good antipyretic effect, energy anti-inflammatory, what control inflammation oozes out and inflammatory hyperplasia, can promote leukocytic phagocytic function, multiple pyococcus and pathogenic entero becteria are had to stronger bacteriostasis, comprise staphylococcus, hemolytic streptococcus, diplococcus meningitidis, shigella dysenteriae, typhoid bacillus, ewcastle disease, Pseudomonas aeruginosa, tubercle bacillus etc.
The root of large-flowered skullcap: bitter, cold in nature, enter the heart, lung, stomach, courage, large intestine channel, there is heat-clearing and damp-drying drug, purging intense heat and detonicating, antiabortive, the effect of hemostasis, the diarrhoea, dysentery, jaundice, the heat that are mainly used in due to damp and hot are drenched; Cough with lung heat, thirsty pharyngalgia, also can be used for fetal movement with fever, and hot malicious fire-evil is invaded the swollen card of sore carbuncle poison of excessive skin.That the root of large-flowered skullcap has is antipyretic, calm, hypotensive, diuresis, reduction capillary permeability, suppress the effects such as intestinal tube wriggling, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumopniae, typhoid bacillus, dysentery coccus, ewcastle disease, Pseudomonas aeruginosa are had to certain inhibitory action, the infection of the upper respiratory tract, chronic bronchitis, bacillary dysentery etc. are had to good curative effect.
The tuber of pinellia: function is eliminating dampness and eliminating phlegm, and stomach preventing or arresting vomiting, cure mainly the wet water drink of phlegm, and vomiting is coughed and the disease such as breathed heavily.
Java brucea: bitter, cold.Slightly poisonous, tool is clearing heat and detoxicating, only dysentery, preventing malaria, the function of corrosion wart.Cure mainly dysentery, malaria; Control wart, corn outward.
The micro-hardship of Sculellaria barbata, cool.Cure mainly heat-clearing, removing toxic substances, the loose stasis of blood, hemostasis, analgesic therapy, controls haematemesis, nosebleed, blood drenches, dysentery characterized by blood in the stool, jaundice, has sore throat, lung carbuncle, furunculosis, scrofula, sore, cancerous swelling, falls the wound of forging a knife, snake bite.Modern pharmacology research shows that Sculellaria barbata has effect clearing heat and detoxicating, promoting blood circulation and removing blood stasis, antitoxin snake bite.Formula is often made Sculellaria barbata and other Chinese herbal medicines by China, and treatment hepatitis and various cancer are as cancer of the stomach, the carcinoma of the rectum, lung cancer, lymph cancer and gynecological tumor etc.
Bletilla: property hardship, sweet, puckery, cold nature, enters lung, stomach, Liver Channel, has the effect of astringing to arrest bleeding, detumescence life, is mainly used in the hemoptysis of the deficiency syndrome of the lung, tuberculosis, yin asthenia generating intrinsic heat, the haematemesis of thermal burn stomach network; The cards such as traumatism and bleeding, bletilla has erythrocyte aggregation and local hemostatic the renting of promotion, has an anastalsis to gastric duodenal ulcer is hemorrhage.
Radix Codonopsis: taste is sweet, property is flat, enters lung, the spleen channel, has tonifying Qi benefit spleen, the symptoms such as the effect of nourishing blood to promote the production of body fluid, is mainly used in spleen-lung Qi deficiency or qi-blood deficiency lassitude hypodynamia, breathes hard, cough spontaneous perspiration, Radix Codonopsis is longer than tonifying spleen nourishing the stomach, adjust regulating the function of middle-JIAO, have the effect of nourishing blood concurrently, its property is flat, invigorating the spleen fortune and not dry; Flavour is cloudy and not wet, can improve the immune state of body, improves resistance against diseases, promotes to digest and assimilate, and improves metabolism, promotes the absorption of enteron aisle to nutriment.
Capsule of weeping forsythia hardship, is slightly cold.Return lung, the heart, small intestinl channel.Function is clearing heat and detoxicating, dispersing swelling and dissipating binds.For ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease is from the beginning of, warm joining the army, high hot polydipsia, coma is sent out spot, and heat is drenched renal shutdown.The medicinal part of the capsule of weeping forsythia is mainly fruit.Its shell, i.e. " sticking up " in " a kind of reed mentioned in ancient books sticks up detoxifying pills ".Contain forsythol, coumarin, oleanolic acid, saponin, citrin etc.There is the effects such as heat-clearing, removing toxic substances, dissipating bind apocenosis.Cure mainly warm, sore, scrofula, erysipelas, class's rash, influenza, be decocted in water for oral dose with fruit, or add in prescription.Be usually used in anemopyretic cold.Nature,taste and action: Chinese medicine bitter, cold nature.Clearing heat and detoxicating, mass dissipating and swelling eliminating.Anaesthetic bitter, cool in nature." association day " clearly, antidiarrheal.Cure mainly: Chinese medicine is controlled pyreticosis from the beginning of, anemopyretic cold, heating is vexed, abscess of throat, and macula, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, heat is drenched.The anaesthetic subcutaneous ulcer of harnessing the Yellow River, intestines shouting pain, " association day " disease, intestines heat.Sheng Nong's herbal classic ": main fever and chills, mouse impotence, scrofula, carbuncle is swollen, dislikes sore, goiter and tumor, knot heat, disease due to noxious agents produced by various parasites.
Cordate houttuynia: cold nature, bitter, returns lung channel, bladder, large intestine channel, has clearing heat and detoxicating; Removing pus and relieving carbuncle; The effect of inducing diuresis for treating strangurtia, is mainly used in lung carbuncle pyemesis; Phlegm heat panting is coughed; Throat; Hot dysentery; Carbuncle sore tumefacting virus; Heat is drenched.
The Radix Astragali: taste is sweet, warm in nature, enter spleen, lung channel, there is help spleen soil, elevate a turnable ladder yang-energy, strengthening exterior and reducing sweat, the effects such as holder sore myogenic, are mainly used in the weak anorexia and loose stool due to spleen-lung Qi deficiency, palpitation, the visceral organ ptosis of the sinking of qi of middle-jiao, Qi dysfunction in blood control uterine bleeding is had blood in stool, and rushes down for a long time prolapse of the anus; The spontaneous sweating of exterior deficiency, the cards such as insufficiency of vital energy and blood.The Radix Astragali strengthens heart contraction ability, can improve the blood circulation of whole body, can coronary artery dilator, kidney blood vessel and adder-wort peripheral vessel, make skin blood overactive circulation; Can improve the nonspecific immunity power of body, protect the liver and fall hypoglycemic effect, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumopniae, shigella dysenteriae etc. are had to inhibitory action.The Radix Astragali can significantly affect SPL Information Conduction, realizes immunoregulation effect.
Fruit of Chinese magnoliavine temperature; Sour, sweet; Return lung, the heart, kidney channel; Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming.Breathe heavily for the void of coughing for a long time, emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the feeble pulse of losing heart, interior heat is quenched one's thirst, palpitation and insomnia." Bencao Jingshu " carries: the main beneficial gas person of the fruit of Chinese magnoliavine, and all gas of lung master, acid can be received, and is just entering lung tonifying lung, therefore beneficial gas is also.Its main cough with dyspnea person, the deficiency of vital energy is above stopped up and is not returned unit, and sour flavor having the property of astringing, takes the photograph gas and returns unit, and cough with dyspnea is from removing.Internal lesion caused by overexertion is won thin, tonifying for the deficiency, reinforcing yin essence, beneficial man's essence." not Lu " supports the five internal organs, heat extraction, and flesh person in raw the moon, the special kidney tonifying of the fruit of Chinese magnoliavine, the tonifying five zang organs of holding concurrently, kidney storing essence, essence is contained cloudy strong, receive to take the photograph vital qi and return unit, and public region is warm, and digesting food, steams waste matter and changes precise and tinyly, smart spontaneous, and essence is raw cloudy long, therefore main as above all diseases are also.
Radix scrophulariae: taste is sweet, bitter, salty; Cold nature.Return lung, stomach, kidney channel, has clearing heat and cooling blood, purging intense heat and detonicating, the effect of enriching yin, is mainly used in warm heresy and joins the army, the pericardium that caves in, febrile virulent maculae, consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, Tianjin hinder that constipation, hectic fever due to yin labor are coughed, hot eyes, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
Rhizoma Gastrodiae: taste is sweet, property is flat, enters Liver Channel, have calming the liver to stop the wind, spasmolysis, the effect of removing obstruction in channels to relieve pain, is mainly used in the dizziness and headache of liver-fire flaming; Convulsion due to liver-yang hyperactivity, liver wind agitation or wind phlegm are jammed, the cards such as epilepsy, also for arthralgia due to wind-dampness, articular instability, the meciless card that waits of extremity numbness, rhizoma Gastrodiae has the effect that strengthens body non-specific immune function and cellular immunity, humoral immunity.
Fruit of glossy privet taste is sweet, bitter, cool in nature.Can mend nourishing liver and kidney, improving eyesight.Containing oleanolic acid, sweet mellow wine, glucose, palmitic acid, glyceric acid.Have enhancing immunologic function, rising peripheral leukocytes, strengthens reticuloendothelial system phagocytic activity, strengthens the effect of cellular immunity and humoral immunity; Have cardiac stimulant, diuresis and protect the liver, cough-relieving, laxative, the effect such as antibacterial, anticancer.Purposes: for the deficiency of liver-yin and kidney-yin, soreness of waist tinnitus, poliosis; Unseeing, poor vision; Fever due to yin deficiency.The fruit of glossy privet, sweet-bitter flavor, cool in nature, returns liver kidney channel, has the merit that nourishing liver and kidney, beneficial the moon nourishes blood.Modern medicine study proves, the fruit of glossy privet includes ursolic acid, sweet mellow wine, glucose, fatty wet goods, has cardiac stimulant, diuresis and hepatoprotective effect, can make the leucocyte decline quantity causing because of chemotherapy raise, and staphylococcus aureus, Escherichia coli are had to inhibitory action.
Giant knotweed: mildly bitter flavor, cold nature, return liver, courage, lung channel, there is the effect of expelling wind and removing dampness, loose stasis of blood analgesic therapy, preventing phlegm from forming and stopping coughing, for joint pain, jaundice with damp-heat pathogen, through Bi ， wei lump in the abdomen, coughing with a lot of sputum, scald, injury from falling down, carbuncle sore tumefacting virus.Giant knotweed has and suppresses and killing action staphylococcus aureus, staphylococcus albus, hemolytic streptococcus, micrococcus catarrhalis, ewcastle disease, proteus, Pseudomonas aeruginosa etc.
Radix Glycyrrhizae: taste is sweet, property is flat, enters 12 warps, has clearing heat and detoxicatingly, is in harmonious proportion the property of medicine, the effect of expelling phlegm and arresting coughing, and can invigorating the spleen and in, relieving spasm to stop pain, is mainly used in weakness of the spleen and the stomach abdominal distension and anorexia, weak; Can alleviate contraction pain in abdomen, relax the strong and toxicity of some drugs, alleviate the toxic and side effect of medicine to body or to GI stimulation, by adding Radix Glycyrrhizae can play tonifying Qi neutralization, be in harmonious proportion the effect of each component.
The present invention also provides a kind of fodder compound, comprises above-mentioned Chinese medicine composition additive and feed vector in said composition.
Described feed vector is preferably one or more in corn, wheat, barley, dregs of beans.
The ratio of weight and number of described feed vector and described Chinese medicine composition additive can be 100 weight portions: 0.5～1.5 weight portion, more preferably 100 weight portions: 1～1.5 weight portion.
The present invention also provides a kind of Chinese medicine composition, comprising: the bighead atractylodes rhizome, the root of kudzu vine, Radix Angelicae Sinensis, radix bupleuri, Asian puccoon, safflower, honeysuckle, the root of large-flowered skullcap, the tuber of pinellia, Java brucea, Sculellaria barbata, bletilla, Radix Codonopsis, the capsule of weeping forsythia, cordate houttuynia, the Radix Astragali:, the fruit of Chinese magnoliavine, radix scrophulariae, rhizoma Gastrodiae, the fruit of glossy privet, giant knotweed, Radix Glycyrrhizae.
Further preferably, the Chinese medicine composition that is used for the treatment of swine plague described in is only made up of said components.
In the described Chinese medicine composition that is used for the treatment of swine plague, the ratio of weight and number of various components can be preferably: comprising: bighead atractylodes rhizome 25-35 weight portion, root of kudzu vine 25-35 weight portion, Radix Angelicae Sinensis 35-40 weight portion, radix bupleuri 15-20 weight portion, Asian puccoon 5-10 weight portion, safflower 20-25 weight portion, honeysuckle 25-30 weight portion, root of large-flowered skullcap 10-20 weight portion, tuber of pinellia 10-20 weight portion, Java brucea 10-15 weight portion, Sculellaria barbata 10-14 weight portion, bletilla 10-20 weight portion, Radix Codonopsis 20-30 weight portion, capsule of weeping forsythia 10-15 weight portion, cordate houttuynia 20-25 weight portion, Radix Astragali 20-30 weight portion, fruit of Chinese magnoliavine 10-15 weight portion, radix scrophulariae 10-15 weight portion, rhizoma Gastrodiae 10-20 weight portion, fruit of glossy privet 10-15 weight portion, giant knotweed 10-15 weight portion, Radix Glycyrrhizae 10-30 weight portion.
In the described Chinese medicine composition that is used for the treatment of animal swine plague, the ratio of weight and number of various components also can be more preferably: bighead atractylodes rhizome 25-30 weight portion, root of kudzu vine 25-30 weight portion, Radix Angelicae Sinensis 35-40 weight portion, radix bupleuri 15-18 weight portion, Asian puccoon 5-8 weight portion, safflower 20-25 weight portion, honeysuckle 25-30 weight portion, root of large-flowered skullcap 10-20 weight portion, tuber of pinellia 10-15 weight portion, Java brucea 10-15 weight portion, Sculellaria barbata 10-14 weight portion, bletilla 10-15 weight portion, Radix Codonopsis 20-25 weight portion, capsule of weeping forsythia 10-15 weight portion, cordate houttuynia 20-25 weight portion, Radix Astragali 25-30 weight portion, fruit of Chinese magnoliavine 12-15 weight portion, radix scrophulariae 10-15 weight portion, rhizoma Gastrodiae 15-20 weight portion, fruit of glossy privet 10-15 weight portion, giant knotweed 10-15 weight portion, Radix Glycyrrhizae 20-30 weight portion.
Further preferably, the Chinese medicine composition that is used for the treatment of swine plague described in is only made up of said components.
Described Chinese medicine composition formulation can be decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule, jelly or syrup, is all to adopt conventional method to be prepared from.
The administering mode of described Chinese medicine composition is oral or injection.
Below describe, in general terms the present invention, further understanding can obtain by reference to some specific embodiments, described embodiment only provides for purposes of illustration, it is restrictive being not intended.In explanation in following examples, except as otherwise noted, quantitaes is in the part by weight of umber.
The preparation of embodiment 1 Chinese medicine composition additive 1
By bighead atractylodes rhizome 25g, the root of kudzu vine 25 g, Radix Angelicae Sinensis 35 g, radix bupleuri 15g, Asian puccoon 5 g, safflower 20 g, honeysuckle 25 g, the root of large-flowered skullcap 10 g, the tuber of pinellia 10 g, Java brucea 10 g, Sculellaria barbata 10 g, bletilla 10 g, Radix Codonopsis 20 g, the capsule of weeping forsythia 10 g, cordate houttuynia 20 g, the Radix Astragali 25 g, the fruit of Chinese magnoliavine 12 g, radix scrophulariae 10 g, rhizoma Gastrodiae 15-20 g, the fruit of glossy privet 10 g, giant knotweed 10 g, Radix Glycyrrhizae 20 g.Mix and pulverize; After sieving, fully mix and make powder.
The preparation of embodiment 2 Chinese medicine composition additives 2
By bighead atractylodes rhizome 25g, the root of kudzu vine 25 g, Radix Angelicae Sinensis 35 g, radix bupleuri 15g, Asian puccoon 5 g, safflower 20 g, honeysuckle 25 g, the root of large-flowered skullcap 10 g, the tuber of pinellia 10 g, Java brucea 10 g, Sculellaria barbata 10 g, bletilla 10 g, Radix Codonopsis 20 g, the capsule of weeping forsythia 10 g, cordate houttuynia 20 g, the Radix Astragali 25 g, the fruit of Chinese magnoliavine 12 g, radix scrophulariae 10 g, rhizoma Gastrodiae 15-20 g, the fruit of glossy privet 10 g, giant knotweed 10 g, Radix Glycyrrhizae 20 g.Mix and pulverize; Add the water with respect to mixture quality 1500ml, decoct and process 2 hours, decoction liquor is filtered, concentration, obtains the lotion of removing moisture, the ethanol that is 65% ~ 75% by the determining alcohol that adds 2000ml in the lotion of acquisition, stir 30 minutes, at 0～4 DEG C, refrigerate 1.5 hours, filter, decompression recycling ethanol, add appropriate medicinal dextrin to mix, granulate, dry, be ground into 100 object powder, granulation agent (every 1g is equivalent to crude drug in whole 2g).
The preparation of embodiment 3 Chinese medicine composition additives 3
By bighead atractylodes rhizome 30g, the root of kudzu vine 30 g, Radix Angelicae Sinensis 40 g, radix bupleuri 18 g, Asian puccoon 8 g, safflower 25 g, honeysuckle 30 g, the root of large-flowered skullcap 20 g, the tuber of pinellia 15 g, Java brucea 15 g, Sculellaria barbata 14 g, bletilla 15 g, Radix Codonopsis 25 g, the capsule of weeping forsythia 15 g, cordate houttuynia 25 g, the Radix Astragali 30 g, the fruit of Chinese magnoliavine 15 g, radix scrophulariae 15 g, rhizoma Gastrodiae 20 g, the fruit of glossy privet 15 g, giant knotweed 15 g, Radix Glycyrrhizae 30 g.Mix and pulverize; After sieving, fully mix and make powder.
The preparation of embodiment 4 Chinese medicine composition additives 4
By bighead atractylodes rhizome 30g, the root of kudzu vine 30 g, Radix Angelicae Sinensis 40 g, radix bupleuri 18 g, Asian puccoon 8 g, safflower 25 g, honeysuckle 30 g, the root of large-flowered skullcap 20 g, the tuber of pinellia 15 g, Java brucea 15 g, Sculellaria barbata 14 g, bletilla 15 g, Radix Codonopsis 25 g, the capsule of weeping forsythia 15 g, cordate houttuynia 25 g, the Radix Astragali 30 g, the fruit of Chinese magnoliavine 15 g, radix scrophulariae 15 g, rhizoma Gastrodiae 20 g, the fruit of glossy privet 15 g, giant knotweed 15 g, Radix Glycyrrhizae 30 g.Mix and pulverize; Add the water with respect to mixture quality 2000ml, decoct and process 2 hours, decoction liquor is filtered, concentration, obtains the lotion of removing moisture, the ethanol that is 65% ~ 75% by the determining alcohol that adds 2500ml in the lotion of acquisition, stir 30 minutes, at 0～4 DEG C, refrigerate 1.5 hours, filter, decompression recycling ethanol, add appropriate medicinal dextrin to mix, granulate, dry, be ground into 100 object powder, granulation agent (every 1g is equivalent to crude drug in whole 2g).
The preparation of embodiment 5 Chinese medicine composition additives 5
By bighead atractylodes rhizome 28g, the root of kudzu vine 28 g, Radix Angelicae Sinensis 40 g, radix bupleuri 15 g, Asian puccoon 6 g, safflower 23 g, honeysuckle 28 g, the root of large-flowered skullcap 15 g, the tuber of pinellia 12 g, Java brucea 12 g, Sculellaria barbata 12 g, bletilla 12 g, Radix Codonopsis 22 g, the capsule of weeping forsythia 12 g, cordate houttuynia 22 g, the Radix Astragali 28 g, the fruit of Chinese magnoliavine 13 g, radix scrophulariae 12 g, rhizoma Gastrodiae 18 g, the fruit of glossy privet 12 g, giant knotweed 12 g, Radix Glycyrrhizae 25 g.Mix and pulverize; After sieving, fully mix and make powder.
The preparation of embodiment 6 Chinese medicine composition additives 6
By bighead atractylodes rhizome 28g, the root of kudzu vine 28 g, Radix Angelicae Sinensis 40 g, radix bupleuri 15 g, Asian puccoon 6 g, safflower 23 g, honeysuckle 28 g, the root of large-flowered skullcap 15 g, the tuber of pinellia 12 g, Java brucea 12 g, Sculellaria barbata 12 g, bletilla 12 g, Radix Codonopsis 22 g, the capsule of weeping forsythia 12 g, cordate houttuynia 22 g, the Radix Astragali 28 g, the fruit of Chinese magnoliavine 13 g, radix scrophulariae 12 g, rhizoma Gastrodiae 18 g, the fruit of glossy privet 12 g, giant knotweed 12 g, Radix Glycyrrhizae 25 g.Mix and pulverize; Add the water with respect to mixture quality 2000ml, decoct and process 2 hours, decoction liquor is filtered, concentration, obtains the lotion of removing moisture, the ethanol that is 65% ~ 75% by the determining alcohol that adds 2500ml in the lotion of acquisition, stir 30 minutes, at 0～4 DEG C, refrigerate 1.5 hours, filter, decompression recycling ethanol, add appropriate medicinal dextrin to mix, granulate, dry, be ground into 100 object powder, granulation agent (every 1g is equivalent to crude drug in whole 2g).
The preparation of embodiment 7 Chinese medicine composition additives 7
By bighead atractylodes rhizome 28g, the root of kudzu vine 28 g, Radix Angelicae Sinensis 40 g, radix bupleuri 15 g, Asian puccoon 6 g, safflower 23 g, honeysuckle 28 g, the root of large-flowered skullcap 15 g, the tuber of pinellia 12 g, Java brucea 12 g, Sculellaria barbata 12 g, bletilla 12 g, Radix Codonopsis 22 g, the capsule of weeping forsythia 12 g, cordate houttuynia 22 g, the Radix Astragali 28 g, the fruit of Chinese magnoliavine 13 g, radix scrophulariae 12 g, rhizoma Gastrodiae 18 g, the fruit of glossy privet 12 g, giant knotweed 12 g, Radix Glycyrrhizae 25 g.Mix and pulverize; Medicinal material was soaked after 2 hours with 2500 water, then decoct to boiling with fire, then decoct 30 minutes with little fire, filter little fiery decoction twice for filter residue, each 1 hour.Merging filtrate, adding ethanol to ethanol content in filtrate after filtrate is concentrated is 70%, filters, and filtrate recycling ethanol, is concentrated into every 1ml and is equivalent to crude drug in whole 1g, and refrigeration, filtration, smart filter, embedding, sterilizing, be prepared into injection.
The preparation of embodiment 8 feed vectors
6kg corn, 2kg dregs of beans, 2kg paddy are put into mixer and stir 20 minutes, pour into subsequently in pulverizer and be ground into 30 object powder, obtain feed vector.
The preparation of embodiment 9 feeds 1
Chinese medicine composition additive 5 is mixed and made with feed vector.
The preparation of embodiment 10 feeds 2
Chinese medicine composition additive 6 is mixed and made with feed vector.
Clinical trial
The toxicity test of Chinese medicine composition additive
Choose body weight and be 120 of the mouse of 18g-20g, be divided into 3 groups (female half and half), injection Chinese medicine composition adds 7 parenteral solution, three groups of dosage are determined 5g (crude drug)/kg successively, 10g (crude drug)/kg, 15g (crude drug)/kg, each dosage is all according to every mouse 0.5ml injection, the behavior performance of observed and recorded device and death condition in 7 days, and in injection latter 8 hours, 24 hours every group get respectively 5 of mouse and slaughter and cut open inspection, blood picture is carried out in blood sampling simultaneously, serum GPT detects, part mouse is carried out to histological examination, on inspection, in 7 days all there is not acute poisoning symptom and death in each group mouse, each group mouse movement is active, gait is coordinated, smooth by hair, eyes are ruddy god, appetite, diet, ight soil is all normal, after slaughtering, cut open each group of Organs of Mice of inspection all without pathology, liver histological inspection is all normal, the active testing result of blood picture and serum GPT and normal mouse are without significant difference, all in normal range (NR), therefore, the security of Chinese medicine composition additive of the present invention is higher.
Curative effect determinate standard
Invalid: during treatment, not have effect or DeGrain to be considered as invalid;
Effective: during treatment, symptom obviously alleviates, recovery from illness or not recovery from illness, be all considered as effectively;
Recovery from illness: during treatment, sick pig returns to one's perfect health, spirit, appetite, defecation, body temperature etc. all recover to be normally considered as recovery from illness.
Test method: selective body focuses between 25～30kg and 80 of healthy piglets, and it is divided into 4 groups at random, 20 every group, is designated as 1,2,3,4 group.Wherein 1,2,3 group of artificial challenge's swine plague, 4 groups is healthy group.1 group is pharmaceutical preparation group of the present invention, the feed being mixed to get by the amount feed for nursing 0.5kg(Chinese medicine composition additive of per kilogram of body weight 0.2g bulk drug (Chinese medicine composition additive 6) 6 and feed vector), every day 1 time, be used in conjunction 7 days, except above-mentioned 0.5kg Chinese medicine fodder, ad lib does not contain the feed vector of Chinese medicine; 2 groups is gentamicin group, by per kilogram of body weight 2mg drug administration by injection, every day 2 times, is used in conjunction 7 days.3,4 groups for not administration group, is free choice feeding.
Result of the test sees the following form.
Result shows, Chinese medicine fodder of the present invention has good result for the treatment of to swine plague, reduces by 55% than the death rate of 3 groups of contrasts.
For example: plant of county of Hunan Province raises 1000 of pigs, and 100 is swine plague through laboratory diagnosis.After morbidity, adopt Chinese medicine fodder treatment of the present invention, the feed that all pigs are mixed to get by the amount feed for nursing 0.5kg(Chinese medicine composition additive of per kilogram of body weight 0.2g bulk drug (Chinese medicine composition additive 6) 6 and feed vector), 7 days courses for the treatment of, be used in conjunction 3 weeks, medication after 7 days the state of an illness controlled.Final dead 5, cure 90, cure rate is 90%, not recurrence.
Feasible according to other improvement and the modification of further embodiment of the present invention according to above-mentioned instruction.The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.Thus, will be understood that, within the scope of the appended claims, the present invention can the mode except specifically describing herein implement.
Claims (7)
1. be used for the treatment of a Chinese medicine fodder for swine plague, it comprises feed vector and Chinese medicine composition additive, it is characterized in that Chinese medicine composition additive is: the bighead atractylodes rhizome, the root of kudzu vine, Radix Angelicae Sinensis, radix bupleuri, Asian puccoon, safflower, honeysuckle, the root of large-flowered skullcap, the tuber of pinellia, Java brucea, Sculellaria barbata, bletilla, Radix Codonopsis, the capsule of weeping forsythia, cordate houttuynia, the Radix Astragali, the fruit of Chinese magnoliavine, radix scrophulariae, rhizoma Gastrodiae, the fruit of glossy privet, giant knotweed, Radix Glycyrrhizae, the ratio of weight and number of the each component in described Chinese medicine composition additive is, bighead atractylodes rhizome 20-40 weight portion, root of kudzu vine 20-35 weight portion, Radix Angelicae Sinensis 30-40 weight portion, radix bupleuri 10-20 weight portion, Asian puccoon 5-15 weight portion, safflower 20-30 weight portion, honeysuckle 20-30 weight portion, root of large-flowered skullcap 10-25 weight portion, tuber of pinellia 10-25 weight portion, Java brucea 10-20 weight portion, Sculellaria barbata 10-15 weight portion, bletilla 10-20 weight portion, Radix Codonopsis 20-30 weight portion, capsule of weeping forsythia 10-15 weight portion, cordate houttuynia 20-25 weight portion, Radix Astragali 20-40 weight portion, fruit of Chinese magnoliavine 10-15 weight portion, radix scrophulariae 10-15 weight portion, rhizoma Gastrodiae 10-20 weight portion, fruit of glossy privet 10-15 weight portion, giant knotweed 10-15 weight portion, Radix Glycyrrhizae 10-40 weight portion.
2. the Chinese medicine fodder that is used for the treatment of swine plague as claimed in claim 1, the ratio of weight and number of the each component in described Chinese medicine composition additive is, bighead atractylodes rhizome 25-35 weight portion, root of kudzu vine 25-35 weight portion, Radix Angelicae Sinensis 35-40 weight portion, radix bupleuri 15-20 weight portion, Asian puccoon 5-10 weight portion, safflower 20-25 weight portion, honeysuckle 25-30 weight portion, root of large-flowered skullcap 10-20 weight portion, tuber of pinellia 10-20 weight portion, Java brucea 10-15 weight portion, Sculellaria barbata 10-14 weight portion, bletilla 10-20 weight portion, Radix Codonopsis 20-30 weight portion, capsule of weeping forsythia 10-15 weight portion, cordate houttuynia 20-25 weight portion, Radix Astragali 20-30 weight portion, fruit of Chinese magnoliavine 10-15 weight portion, radix scrophulariae 10-15 weight portion, rhizoma Gastrodiae 10-20 weight portion, fruit of glossy privet 10-15 weight portion, giant knotweed 10-15 weight portion, Radix Glycyrrhizae 10-30 weight portion.
3. the Chinese medicine fodder that is used for the treatment of swine plague as claimed in claim 1, the ratio of weight and number of the each component in described Chinese medicine composition additive is, bighead atractylodes rhizome 25-30 weight portion, root of kudzu vine 25-30 weight portion, Radix Angelicae Sinensis 35-40 weight portion, radix bupleuri 15-18 weight portion, Asian puccoon 5-8 weight portion, safflower 20-25 weight portion, honeysuckle 25-30 weight portion, root of large-flowered skullcap 10-20 weight portion, tuber of pinellia 10-15 weight portion, Java brucea 10-15 weight portion, Sculellaria barbata 10-14 weight portion, bletilla 10-15 weight portion, Radix Codonopsis 20-25 weight portion, capsule of weeping forsythia 10-15 weight portion, cordate houttuynia 20-25 weight portion, Radix Astragali 25-30 weight portion, fruit of Chinese magnoliavine 12-15 weight portion, radix scrophulariae 10-15 weight portion, rhizoma Gastrodiae 15-20 weight portion, fruit of glossy privet 10-15 weight portion, giant knotweed 10-15 weight portion, Radix Glycyrrhizae 20-30 weight portion.
4. the Chinese medicine fodder that is used for the treatment of swine plague as claimed in claim 1, wherein, feed vector is one or more mixing in corn, dregs of beans, wheat bran, paddy.
5. be used for the treatment of a Chinese medicine composition for animal swine plague, made by following raw materials according: the bighead atractylodes rhizome, the root of kudzu vine, Radix Angelicae Sinensis, radix bupleuri, Asian puccoon, safflower, honeysuckle, the root of large-flowered skullcap, the tuber of pinellia, Java brucea, Sculellaria barbata, bletilla, Radix Codonopsis, the capsule of weeping forsythia, cordate houttuynia, the Radix Astragali, the fruit of Chinese magnoliavine, radix scrophulariae, rhizoma Gastrodiae, the fruit of glossy privet, giant knotweed, Radix Glycyrrhizae, the ratio of weight and number of the each component in described Chinese medicine composition is, bighead atractylodes rhizome 25-30 weight portion, root of kudzu vine 25-30 weight portion, Radix Angelicae Sinensis 35-40 weight portion, radix bupleuri 15-18 weight portion, Asian puccoon 5-8 weight portion, safflower 20-25 weight portion, honeysuckle 25-30 weight portion, root of large-flowered skullcap 10-20 weight portion, tuber of pinellia 10-15 weight portion, Java brucea 10-15 weight portion, Sculellaria barbata 10-14 weight portion, bletilla 10-15 weight portion, Radix Codonopsis 20-25 weight portion, capsule of weeping forsythia 10-15 weight portion, cordate houttuynia 20-25 weight portion, Radix Astragali 25-30 weight portion, fruit of Chinese magnoliavine 12-15 weight portion, radix scrophulariae 10-15 weight portion, rhizoma Gastrodiae 15-20 weight portion, fruit of glossy privet 10-15 weight portion, giant knotweed 10-15 weight portion, Radix Glycyrrhizae 20-30 weight portion.
6. one kind is used for the treatment of the Chinese medicine composition of animal swine plague, described Chinese medicine composition is prepared from by the following method: each component in Chinese medicine composition described in claim 5 is mixed in proportion, obtain mixture, add the water with respect to 2 ~ 4 times of mixture qualities, decoct and process 1～3 hour, decoction liquor is filtered, concentration, obtain the lotion of removing moisture, by the ethanol that to add with respect to the determining alcohol of 3～5 times of first step mixture qualities in the lotion of acquisition be 65% ~ 75%, stir 20 minutes ~ 40 minutes, at 0～4 DEG C, refrigerate 1 ~ 2 hour, filter, decompression recycling ethanol, obtain and get dry extract, be ground into 100 order ~ 200 object powder.
7. the application of the Chinese medicine composition described in claim 5 in the medicine for the preparation for the treatment of swine plague.
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| CN105104871A (en) * | 2015-09-15 | 2015-12-02 | 福建省漳州市华龙饲料有限公司 | Feeding attraction feed for piglets |
| CN107048003A (en) * | 2017-02-09 | 2017-08-18 | 合肥隆扬农业科技有限公司 | One kind preventing and treating sow feed lungy |
| CN107048008A (en) * | 2017-03-14 | 2017-08-18 | 滁州菲扬农业科技有限公司 | A kind of feed addictive and preparation method for preventing and treating swine plague |
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| JP2603977B2 (en) * | 1987-12-26 | 1997-04-23 | 日清製粉株式会社 | Prevention and treatment of Pasteurella haemolytica infection in livestock |
| CN1245707A (en) * | 1999-08-12 | 2000-03-01 | 黄英秀 | Chinese medicine for curing AIDS and carcinomatosis |
| CN101874883A (en) * | 2009-04-28 | 2010-11-03 | 姜国银 | Traditional Chinese medicine for preventing and treating high fever diseases of pigs |
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Effective date of registration: 20201222 Address after: 253211 Guozhai forest farm, suliuzhuang Town, Xiajin County, Dezhou City, Shandong Province Patentee after: XIAJIN NEW HOPE LIUHE AGRICULTURE AND ANIMAL HUSBANDRY Co.,Ltd. Address before: 266111 Qingdao Industrial Park, Ji Hong Tan Street, Chengyang District, Qingdao, Shandong. Patentee before: SHANDONG NEW HOPE LIUHE GROUP Co.,Ltd. |
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Address after: 253211 Guozhai Forest Farm, Suliuzhuang Town, Xiajin County, Dezhou City, Shandong Province (5F, Qingwo Pioneer Park Office Building, Xiajin Economic Development Zone) Patentee after: XIAJIN NEW HOPE LIUHE AGRICULTURE AND ANIMAL HUSBANDRY Co.,Ltd. Address before: 253211 Guozhai forest farm, suliuzhuang Town, Xiajin County, Dezhou City, Shandong Province Patentee before: XIAJIN NEW HOPE LIUHE AGRICULTURE AND ANIMAL HUSBANDRY Co.,Ltd. |